Family of Thermo Scientific DynaDrive Single-Use Bioreactors with capacities of 5,000 L, 3,000 L, 500 L, and 50 L.

A next-level innovation in single-use bioreactors—unmatched design, scalability, and performance

The Thermo Scientific HyPerforma DynaDrive Single-Use Bioreactor (S.U.B.) is our latest innovation in single-use bioreactors, continuing the success of the robust HyPerforma bioreactors first launched in 2006 and updated in 2013. This new design provides improved performance and scalability to larger volumes and is suitable for fed-batch and perfusion processes. This HyPerforma DynaDrive S.U.B. helps ensure optimal cell culture performance across all scales and increased cell densities.

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Explore the DynaDrive S.U.B. 3D Product Tour

Virtually interact with our 5,000 L DynaDrive S.U.B. to learn more about the overall design elements and operations, experience an inside view of the mixing technology, turndown performance, and view a seed train sequence all within this 3D product tour.

Substitute high costs for high performance with the DynaDrive S.U.B.

  • Ability to decrease the cost of production by 25% through the reduction of equipment, materials, consumables, and labor, enabled by the increased reactor size, lowering the number of production batches required for a given volumetric demand.
  • Provides a lower average cost per gram and net present cost of investment up to scales of 4,200 kilograms per year of production.

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  • Leveraging higher in-vessel turndown ratios to run multiple stages in a single bioreactor can reduce the number of bags loaded and unloaded as well as the number of bioreactors needed overall in the facility.
  • Available in 50 L, 500 L, 3,000 L, and 5,000 L providing efficiency in manufacturing with improved mass transfer and mixing; this allows for the use of the same technology over a larger range of facility networks thus simplifying process transfers from research and development to commercial manufacturing phases.

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  • The DynaDrive S.U.B. has been designed specifically to increase power input per volume (PIV). The flexible drive train includes multiple impellers that provide more PIV while still maintaining reasonable RPM and tip speeds. The unique drive train is also flexible, which allows the BPC to be folded to minimize the size of packaging and improve BPC deployment and disassembly.
  • A >10:1 turndown ratio allows you to optimize the seed train which helps reduce labor and risk while improving facility space utilization. With this turndown ratio, you can transfer highly concentrated cells directly from cell culture flasks to the bioreactor.
Decrease production costs
  • Ability to decrease the cost of production by 25% through the reduction of equipment, materials, consumables, and labor, enabled by the increased reactor size, lowering the number of production batches required for a given volumetric demand.
  • Provides a lower average cost per gram and net present cost of investment up to scales of 4,200 kilograms per year of production.

Download White Paper

Efficient and scalable manufacturing
  • Leveraging higher in-vessel turndown ratios to run multiple stages in a single bioreactor can reduce the number of bags loaded and unloaded as well as the number of bioreactors needed overall in the facility.
  • Available in 50 L, 500 L, 3,000 L, and 5,000 L providing efficiency in manufacturing with improved mass transfer and mixing; this allows for the use of the same technology over a larger range of facility networks thus simplifying process transfers from research and development to commercial manufacturing phases.

Read Application Note

Higher performance and flexibility
  • The DynaDrive S.U.B. has been designed specifically to increase power input per volume (PIV). The flexible drive train includes multiple impellers that provide more PIV while still maintaining reasonable RPM and tip speeds. The unique drive train is also flexible, which allows the BPC to be folded to minimize the size of packaging and improve BPC deployment and disassembly.
  • A >10:1 turndown ratio allows you to optimize the seed train which helps reduce labor and risk while improving facility space utilization. With this turndown ratio, you can transfer highly concentrated cells directly from cell culture flasks to the bioreactor.
Ordering information
50 L DynaDrive S.U.B. and BPC
500 L DynaDrive S.U.B. and BPC
3,000 L DynaDrive S.U.B. and BPC
5,000 L DynaDrive S.U.B. and BPC

Related resources

 Application note: DynaDrive S.U.B.s
 Application note: DynaDrive S.U.B. for perfusion cell culture applications
 Application note: Scale-up evaluation of the DynaDrive S.U.B.s
 Application note: Streamlining seed train scale-up through utilization of the turndown ratio of the DynaDrive S.U.B.
 Application note: Process performance comparison between the 50 L DynaDrive S.U.B. and legacy S.U.B. platforms
 Application note: Production of AAV vector in S.U.B.s using the ExpiSf Expression System
 Brochure: Modular perfusion workflow
 Brochure: DynaDrive S.U.B.
 Data Sheet: 50 L DynaDrive S.U.B.
 Data Sheet: 500 L DynaDrive S.U.B.
 Data Sheet: 3,000 L and 5,000 L DynaDrive S.U.B.
 White Paper: Enabling high-performing perfusion cell culture
 White Paper: 5,000 L S.U.B.s: The next generation in biologics manufacturing

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