Vanquish Flex UHPLC Systems | Thermo Fisher Scientific

Easier method development and routine analysis

For assays that require more flexibility to accommodate all applications, the Thermo Scientific Vanquish Flex UHPLC systems enable you to increase your productivity and drive innovation without compromising quality. Whether you need an LC or LC-MS solution, the flexibility of the Vanquish Flex systems with binary or quaternary solvent blending provides the most advanced performance through better separations, more results and easier interaction.

New benchmarks in accuracy, precision, and sensitivity

As a member of the Vanquish UHPLC product line, the Vanquish Flex Binary UHPLC system and Vanquish Flex Quaternary UHPLC system share all Vanquish-inherent values, such as a design focus on uptime, robustness and reliability. The Vanquish Flex systems provide:

Unsurpassed retention time and peak area precision
Highest detector sensitivity and lowest baseline noise
Less maintenance and easy set-up with Thermo Scientific Viper fingertight fittings
Dedicated solutions for exceptional LC-MS performance

Also benefit from the industry-leading, easy-to-use and compliant Thermo Scientific Chromeleon Chromatography Data System (CDS) with eWorkflow method setup, dedicated ePanels, Open Access, and smart tools. Chromeleon CDS delivers advanced system communication with single-point intelligent control and functionality, and provides direct plugins for the Vanquish Flex UHPLC systems to other manufacturers' chromatography data systems.

Choose from two Vanquish Flex UHPLC systems

Vanquish Flex Binary UHPLC System

Biocompatible with a state-of-the-art binary high-pressure pump and state-of-the-art binary solvent blending
Ideal for extended throughput that can be seamlessly coupled to a mass spectrometer (MS).

Vanquish Flex Quaternary UHPLC System

A biocompatible UHPLC system with state-of-the-art low-pressure quaternary solvent blending.
Ideal for pharmaceutical and biopharmaceutical applications.

Continuous, worry-free operation

Reliable and continuous worry-free operation of HPLC instruments is critical for analytical laboratories to achieve the highest productivity and dependable results.

The Thermo Scientific Vanquish Solvent Monitor delivers productivity improvements through the avoidance of unintended dry solvent channels and supports your laboratory's compliance efforts by automatically logging eluent changes. Additionally, monitoring of your waste container levels can ensure your laboratory's smooth operation by preventing hazardous spills.

Solvent and waste levels can be monitored directly on the instrument, through the Thermo Scientific Vanquish User Interface, or remotely with Thermo Scientific Chromeleon Chromatography Data System (CDS) software.

Continuous awareness of system status

Lab professionals spend a large amount of time interacting with laboratory instruments. The more quickly that operators can understand system status, the more easily they can keep the system delivering results.

With the crisply-designed Thermo Scientific Vanquish User Interface, system health, performance, and equilibration status can be seen at a glance. Additionally, simple maintenance tutorials guide operators to keep the system dependably delivering results. All this can be done remotely or locally, and even when there is no CDS.

Chromeleon Chromatography Data System (CDS)

Also benefit from the industry-leading, easy-to-use Thermo Scientific Chromeleon CDS software with eWorkflow method setup, dedicated ePanels, and smart tools. Chromeleon CDS delivers advanced system communication with single-point intelligent control and functionality, and provides direct plugins for the Vanquish Horizon UHPLC system to other manufacturers' chromatography data systems.

Chromatography columns and consumables

Find the right solutions for your workflow and achieve better separations. Choose from more than 4,000 products across sample preparation and handling through to columns, including products bundles specifically selected for use with Thermo Scientific Vanquish UHPLC systems.

Overview of the Vanquish UHPLC systems

		Vanquish Flex Binary UHPLC System	Vanquish Flex Quaternary UHPLC System
	Solvent blending	High pressure binary solvent blending for fast and reliable UHPLC	Low pressure quaternary solvent blending for flexible method development
Performance	System pressure	Up to 1000 bar
	Retention time precision
	Flow range	0 – 8 mL/min
	Biocompatibility
System Features	Design	Modular	Modular
	SmartInject technology for unsurpassed retention time precision
	SmartFlow technology for excellent flow precision
	Pump	High-pressure gradient proportioning	Low-pressure gradient proportioning
	Active and passive pre-heating
	Multi-mode column thermostatting
	Sample cooling	Temperature range: 4 – 40 °C	Temperature range: 4 – 40 °C
System components	Pump	Vanquish Binary Pump F UHPLC performance for demanding routine application up to 1000 bar	Vanquish Quaternary Pump F UHPLC performance with more solvent flexibility up to 1000 bar
	Autosampler	Vanquish Split Sampler FT For applications up to 1000 bar
	Extended sample capacity	Vanquish Charger (optional) An intelligent, robotic rack and plate feeder that automatically loads samples in the autosampler and extends the sample capacity of all Vanquish samplers to up to 8832 samples (23 wellplates or 12 vial racks) with innovative air-stream cooling and barcode reading for inventory management.
	Column compartment	Vanquish Column Compartment Provides two column thermostatting modes (still and forced air), active and passive solvent pre-conditioning and post-column cooling for optimized control of your separations and advanced method transfer.
	Virtually zero dead volume system connections	Viper UHPLC Fittings Kits Order all the UHPLC fittings and capillaries you need for your system or application in a single kit

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Compatible components for all Vanquish UHPLC systems

Detector options	Vanquish columns	Chromeleon CDS
Vanquish Charged Aerosol Detectors Vanquish Diode Array Detectors Vanquish Fluorescence Detectors Vanquish Variable Wavelength Detector Mass Spectrometers	Extend pressure capabilities and robustness by using columns that were developed for Vanquish systems, allowing you to separate your science better, faster, and easier than ever before. Accucore Vanquish C18+ Acclaim Vanquish C18 Acclaim Vanquish Polar Advantage II Hypersil GOLD Vanquish aQ Hypersil GOLD Vanquish C18 Hypersil GOLD Vanquish PFP (pentafluorophenyl) All Vanquish systems can be used with any of our HPLC and UHPLC columns	Streamlines your data processing Industry-leading ease of use and intelligent functionalities Outstanding data integrity Unique user guidance and hardware automation features designed for Vanquish systems

Discover the best HPLC systems for your applications and budget

Discover the best HPLC system for your applications and budget

Use these tools to help you decide

HPLC Systems Selection Guide
Use this tool to rank the top HPLC instruments for your applications based on your responses to simple pull-down menus.

HPLC System Total Cost of Ownership Calculator
Use this tool to estimate your cost for purchasing and running Thermo Scientific HPLC and UHPLC systems. You can compare costs between instruments.

LC Method Transfer Calculator
Use this online calculator to transfer methods from HPLC to UHPLC conditions. Calculate the new gradient table, adjust sample volumes and run times if applicable.

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