LanthaScreen Cellular Assays Validation Table

LanthaScreen cellular assays are developed to ensure proper pharmacology toward the target of interest.  Each assay provides excellent response profiles, yields a Z´-factor above 0.6, and demonstrates the appropriate EC50/IC50 responses to known agonists or antagonists.  In addition, the cell lines used in LanthaScreen cellular assays are mycoplasma-negative and tested for optimal performance under a variety of experimental conditions.  Our goal is to provide effective tools with robust results to keep your screening program on track.

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See the list of available LanthaScreen cellular assays below, along with validation data and assay protocols specific to detection of each post-translational modification.

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Target Substrate	Modification Detected	Cell Line Name	Cell Line Cat.#	Antibody	Validation Packet	Customer Protocol
AKT	Phosphorylation of Ser473	LanthaScreen AKT HEK293E	K1615	LanthaScreen Tb-anti-AKT [pSer473] Antibody
ATF2 (19-106)	Phosphorylation of Thr71	LanthaScreen ATF2 (19-106) A549	K1679B	LanthaScreen Tb-anti-ATF2 [pThr71] Antibody
c-Jun (1-79)	Phosphorylation of Ser73	LanthaScreen c-Jun (1-79) HeLa	K1680	LanthaScreen Tb-anti-c-Jun [pSer73] Antibody
ERK2	Phosphorylation of Thr185/Tyr187	LanthaScreen ERK2 U2OS	K1587	LanthaScreen Tb-anti-ERK2 [pThr185/pTyr187] Antibody
ERK2	Phosphorylation of Thr185/Tyr187	LanthaScreen ERK2 A375 (B-RAF V600E)	K1798	LanthaScreen Tb-anti-ERK2 [pThr185/pTyr187] Antibody
IGF-1R	Phosphorylation of Tyr Residues	LanthaScreen IGF-1R GripTite	K1834	LanthaScreen Tb-PY20 Antibody
IkB	Phosphorylation of Ser32	LanthaScreen IkB GripTite	K1681B	LanthaScreen Tb-anti-pIkB [pSer32] Antibody
PDCD4	Phosphorylation of Ser457	LanthaScreen PDCD4 HEK293E	K1593	LanthaScreen Tb-anti-PDCD4 [pSer457] Antibody
PRAS40	Phosphorylation of Thr246	LanthaScreen PRAS40 HEK293E	K1528	LanthaScreen Tb-anti-PRAS40 [pThr246] Antibody
PRAS40	Phosphorylation of Ser183	LanthaScreen PRAS40 HEK293E	K1528	LanthaScreen Tb-anti-PRAS40 [pSer183] Antibody
STAT1	Phosphorylation of Tyr701	LanthaScreen STAT1 U2OS	K1469	LanthaScreen Tb-STAT1 [pTyr701] Antibody
STAT3	Phosphorylation of Tyr705	LanthaScreen STAT3 GripTite	K1488	LanthaScreen Tb-STAT3 [pTyr705] Antibody
STAT5	Phosphorylation of Tyr694/Tyr699	LanthaScreen STAT5 TF-1	K1598	Anti-STAT5 A/B [pTyr694/699] Antibody
STAT5	Phosphorylation of Tyr694/Tyr699	LanthaScreen STAT5 U2OS (JAK2 V617F)	K1588	Anti-STAT5 A/B [pTyr694/699] Antibody