Custom Cell Engineering Services

Advantages of working with our custom services team:

• Free up valuable resources—outsourcing of key activities can help you accomplish your project goals
• Extensive experience—we have genome edited 100+ cell lines and completed over 500 projects using the Invitrogen BacMam technology and Jump-In system
• Dedicated project managers—our project management team provides dedicated support at every stage of your project

Complete your cell engineering projects in far less time by collaborating with our Custom Biology Services team. Whether your research requires custom engineered cell lines or Jump-In parental cell lines, Thermo Fisher Scientific has the in-house expertise to support and accelerate your cellular projects.

Cell line engineering service leverages one of the most robust and reliable technologies on the market. Utilizing quality products throughout the process, our scientists will work with you to design your stable cell line and perform quality control testing to help ensure that the cell line meets your requirement

Using either CRISPR-Cas9 or TAL effectors as genome-editing tools, we offer a variety of modification options including knock-out and knock-in (SNPs, large donor) for stable cell line generation in a wide variety of cell backgrounds. We have experience working everything from easy-to-transfect cell lines (including HEK 293, 293FT, HCT116, or HeLa) to hard-to-transfect cell lines (including iPSCs, fibroblasts, neuroblastoma-derived, hepatocellular carcinoma, bone marrow–derived, and endothelium-derived cells). How rapidly we can deliver a custom stable pool or stable cell line depends on the cell line, growth characteristics and culturing requirements. Stable cell line engineering services can be completed in as little as 10 weeks. 

For more information, see Stem Cell Genome Editing and Cell Line Engineering Services.
 

Access stable, isogenic mammalian cell lines faster with our Jump-In cell engineering service. Using the Jump-In platform, we can help accelerate your projects through the rapid generation of Jump-In parental cell line in less than 5 weeks. Jump-In technology enables the rapid generation of a pool of cells with a gene of interest integrated at a single genomic locus using targeted integration using R4 integrase. Simply provide us with the target gene mutation of interest and select from an existing parental Jump-In cell lines to create a stable pool that expresses the gene of interest. Jump-In stable pool can be available in as little as 5 weeks.

For more information on our Jump-In service, submit an online inquiry

See how researchers are leveraging the Jump-In system to achieve their research goals:

• Butler et al. (2015) Use of the site-specific retargeting Jump-In platform cell line to support biologic drug discovery. J Biomol Screen 20:528–535.
    
  

Obtain validated, high-throughput screening-ready cells in scale more efficiently with our cryopreservation service. Our standardized, high-quality process yields validated cell lines typically within 2  to 4 weeks.

1. Provide us your cell line or purchase one of our cell lines
2. Our scientists scale-up and produce cryopreserved cells
3. Cell lines are quality control-tested and validated

For more information on our cell banking services, submit an online inquiry or email us