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LanthaScreen Cellular Assays Validation Table
LanthaScreen cellular assays are developed to ensure proper pharmacology toward the target of interest. Each assay provides excellent response profiles, yields a Z´-factor above 0.6, and demonstrates the appropriate EC50/IC50 responses to known agonists or antagonists. In addition, the cell lines used in LanthaScreen cellular assays are mycoplasma-negative and tested for optimal performance under a variety of experimental conditions. Our goal is to provide effective tools with robust results to keep your screening program on track.
See the list of available LanthaScreen cellular assays below, along with validation data and assay protocols specific to detection of each post-translational modification.
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| Target Substrate | Modification Detected | Cell Line Name | Cell Line Cat.# | Antibody | Validation Packet | Customer Protocol |
|---|---|---|---|---|---|---|
| AKT | Phosphorylation of Ser473 | LanthaScreen AKT HEK293E | K1615 | LanthaScreen Tb-anti-AKT [pSer473] Antibody |  | |
| ATF2 (19-106) | Phosphorylation of Thr71 | LanthaScreen ATF2 (19-106) A549 | K1679B | LanthaScreen Tb-anti-ATF2 [pThr71] Antibody | | |
| c-Jun (1-79) | Phosphorylation of Ser73 | LanthaScreen c-Jun (1-79) HeLa | K1680 | LanthaScreen Tb-anti-c-Jun [pSer73] Antibody | | |
| ERK2 | Phosphorylation of Thr185/Tyr187 | LanthaScreen ERK2 U2OS | K1587 | LanthaScreen Tb-anti-ERK2 [pThr185/pTyr187] Antibody | | |
| ERK2 | Phosphorylation of Thr185/Tyr187 | LanthaScreen ERK2 A375 (B-RAF V600E) | K1798 | LanthaScreen Tb-anti-ERK2 [pThr185/pTyr187] Antibody | | |
| IGF-1R | Phosphorylation of Tyr Residues | LanthaScreen IGF-1R GripTite | K1834 | LanthaScreen Tb-PY20 Antibody | | |
| IkB | Phosphorylation of Ser32 | LanthaScreen IkB GripTite | K1681B | LanthaScreen Tb-anti-pIkB [pSer32] Antibody | | |
| PDCD4 | Phosphorylation of Ser457 | LanthaScreen PDCD4 HEK293E | K1593 | LanthaScreen Tb-anti-PDCD4 [pSer457] Antibody | | |
| PRAS40 | Phosphorylation of Thr246 | LanthaScreen PRAS40 HEK293E | K1528 | LanthaScreen Tb-anti-PRAS40 [pThr246] Antibody | | |
| PRAS40 | Phosphorylation of Ser183 | LanthaScreen PRAS40 HEK293E | K1528 | LanthaScreen Tb-anti-PRAS40 [pSer183] Antibody | | |
| STAT1 | Phosphorylation of Tyr701 | LanthaScreen STAT1 U2OS | K1469 | LanthaScreen Tb-STAT1 [pTyr701] Antibody | | |
| STAT3 | Phosphorylation of Tyr705 | LanthaScreen STAT3 GripTite | K1488 | LanthaScreen Tb-STAT3 [pTyr705] Antibody | | |
| STAT5 | Phosphorylation of Tyr694/Tyr699 | LanthaScreen STAT5 TF-1 | K1598 | Anti-STAT5 A/B [pTyr694/699] Antibody | | |
| STAT5 | Phosphorylation of Tyr694/Tyr699 | LanthaScreen STAT5 U2OS (JAK2 V617F) | K1588 | Anti-STAT5 A/B [pTyr694/699] Antibody | | |
For Research Use Only. Not for use in diagnostic procedures.