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Small Molecule Bioanalysis and DMPK Studies
Ensure sensitive, robust analysis for small molecule clinical drug trials
Understanding your molecules is critical, and ensuring accuracy throughout sample preparation, analysis and data interpretation is paramount when it comes to your DMPK studies. Regardless of matrix complexity, sample throughput or sensitivity and linearity requirements, find out what it takes to meet these challenges with ease – all in a 21 CFR Part 11 and GxP compliant environment.
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Remove variability and optimize high-throughput laboratory workflows. Thermo Scientific SOLAµ Solid Phase Extraction (SPE) Plates are designed for bioanalytical research analysts who require cleaner, highly reproducible, and robust sample extraction using very low sample and solvent volumes in high-throughput workflows. SOLAµ Well Plates achieve this due to the unique, award winning innovative frit-less SPE technology.
Designed with innovative technology and fine detail, the Thermo Scientific Vanquish Horizon UHPLC System delivers a new standard in high-end UHPLC – more results with better separations and easier interaction simultaneously, without compromise.
For the most complex samples and the highest throughput, you can be sure that the Vanquish Horizon delivers the utmost confidence for your LC-MS quantitative workflows.
Productivity has been redefined with the Thermo Scientific Orbitrap Exploris 120 mass spectrometer due to its ability to provide consistently accurate results for screening and quantitation applications. Keep your laboratory running seamlessly with reproducible and sensitive results, all on a rugged instrument platform.
Your samples are both precious and limited, the Thermo Scientific TSQ Altis Triple Quadrupole Mass Spectrometer ensures supreme quantitative performance without compromise.
Meet your analytical challenges and goals every day, for every sample with robust, sensitive and efficient targeted quantitation workflows.
TSQ Altis brochure
Application note: Quantitative analysis of drug candidates in plasma
Easily answer critical analytical challenges during targeted quantitation workflows in your laboratory. With the sensitivity and reproducibility to quantitate any molecule in complex biological matrices, the Thermo Scientific TSQ Quantis Triple Quadrupole Mass Spectrometer delivers – workflow driven solutions for absolute confidence.
The Thermo Scientific Watson LIMS Software for Biolanalytical Laboratories, installed in 18 of the top 20 global pharmaceutical organizations, is widely used in leading biotechnology and contract research organizations worldwide. The Watson LIMS facilitates efficient study design and data transfer while streamlining assay validation, bioanalysis, instrument interfacing, sample tracking, results reporting and regulatory compliance.
Study design and analytics to support bioanalysis and DMPK for drug development require high sensitivity mass spectrometry (MS) data and attention to fine detail to manage even the smallest peaks. Thermo Scientific Chromeleon Chromatography Data System (CDS) provides the tools for quick and robust quantitative MS analysis. With full integration of Thermo Scientific gas chromatography (GC)-MS/MS and liquid chromatograph (LC)-MS/MS instruments, as well as more than 550 other instruments from over 25 different vendors, Thermo Scientific Enterprise Chromeleon CDS connectivity facilitates quick method development, seamless method qualification/validation, and streamlined method transfer across laboratories on a global scale while ensuring data integrity requirements for a cGxP environment are met with the secure data vault structure and suite of compliance tools. Confidently run your bioanalytical and DMPK studies from any lab at any site at any time with the stability and performance of Chromeleon CDS.
With Thermo Scientific TraceFinder Software you have the power to develop robust and reliable methods, whilst increasing productivity within your laboratory for your targeted screening and routine quantitative assays; address the challenges both today and tomorrow with unparalleled ease – quantitation with confidence.
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Confident quantitation
Scientists are being challenged to develop quantitation workflows in complex matrices whilst reducing cost per sample, in addition to producing robust, reliable and reproducible solutions.