Antibodies for Cancer Research

There are at least three distinct mitogen-activated protein kinase (MAPK) signaling modules which mediate extracellular signals into the nucleus to turn on the responsive genes in mammalian cells, including ERK, JNK, and p38 kinase. The MAPK signaling pathway is essential in regulating many cellular processes including inflammation, cell differentiation, cell proliferation and death. The role of MAPK pathway in cancer, immune disorders and neurodegenerative diseases has been well recognized. We offer antibodies, ELISAs, Luminex® multiplex assays and growth factors for key targets in the MAPK signaling cascade. Key targets include MAPK1, MAPK2, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, 
MAPK10, MAPK11, MAPK12, MAPK14, MAPK15

The serine–threonine kinase Akt (also known as protein kinase B) is a central convergence node in a broadly influential signaling network. Akt activation serves as a master switch of these cellular signaling pathways, generating a multitude of intracellular responses through a plethora of downstream targets and interacting partners. We offer antibodies, ELISAs, Luminex® multiplex assays and growth factors for key targets in the Akt signaling cascade. Key targets include AKT1, AKT2, AKT3, PI3K.

We offer affinity-purified rabbit polyclonal or monoclonal antibodies that are monospecific for a target protein that is phosphorylated on a specific tyrosine, threonine, or serine residue. Our phosphospecific antibodies can be used in a wide variety of immunodetection applications including immunohistochemistry, quantitative ELISA and flow cytometry. Key targets include SRC, FAK, Tau, EIF2, AKT, ERK, JAK, STAT, MAPK

We offer a wide selection of specific primary antibodies for studying transcription factors that have been validated for multiple applications, such as western blotting, immunfluorescence, ELISA, and immunohistochemistry. Key targets include CREB, E2F-1, c-Myc, c-Fos, AP2, AID, CDX2, ETS1, E2F-1, 4EBP1

GTP hydrolases (GTPases) are capable of binding and cleaving GTP. The GTPase family contains sub families such as the RAS super family which is critical to cell signaling. We offer high-quality antibodies against a number of GTPase targets for use in applications including western blotting, immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry (IHC), and ELISA. Key targets include RAC, RAS, ARF, RHO, RAB, Cdc42

Analyze how cell signaling pathways are disrupted in cancer by accurately quantifying intracellular and extracellular proteins using protein analysis tools designed for single or multiplex cancer biomarker analysis.

Evaluate the hallmarks of cancer with Molecular Probes® branded assays, which have been validated on multiple instrument platforms and applications: microscopy, flow cytometry, microplate readers, and high-content screening.

Visualize intracellular changes in cancer cells right on your benchtop using Molecular Probes® branded assays and the FLoid® Cell Imaging Station. You can also visualize cell cycle progression in live cells with our Premo™ FUCCI Cell Cycle Sensor.

Identify quiescent cancer stem cells and determine their role in metastasis and therapeutic resistance.

Identify, track, and analyze cancer cell signaling events in individual cancer cells using flow cytometry for cell proliferation, cell cycle, apoptosis, and immunophenotyping and detect rare cellular events such as human circulating endothelial cells.