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Gibco Dynamis Medium
Powerful performance in a base medium
Gibco Dynamis Medium provides the power to achieve higher titers, faster process development, and seamless scale-up.
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- Achieved 74% higher titer compared to the next-best competitor, with highest growth in titer from day 14 to day 21 at 30% in CHO cells
- Maintained higher cell densities and cell viabilities than competitors' media when fed with glucose
- Supports robust growth of HEK293 cells for adenovirus production
- Advanced Granulation Technology (AGT) dry media format enables a simple and scalable reconstitution process-just add water
Growth performance of HEK293 in Dynamis Medium
HEK293 cells were seeded at 0.3 x 106 cells/mL in Dynamis Medium supplemented with 4 mM L-Glutamine and cultured in three 60 mL shake flasks (125 rpm, 37°C, 8% CO2). In all flasks, viable cell density (VCD) was measured on days 0, 1, 2, 3, 4, and 7. By day 7, glucose was depleted in the culture. Glucose level monitoring and supplementation (e.g., 2 g/L glucose) at the beginning of the culture or as a supplement on day 4 is recommended. The results show consistent high-density growth performance with HEK293 cells in Dynamis Medium
Dynamis Medium achieved 74% higher titer when compared to the next-best competitor, with glucose-only fed media
A IgG-producing internal CHO clone was cultured in Dynamis Medium or other commercially available media for a period of up to 21 days with glucose levels maintained via supplementation. Titer values were normalized to 100% to the best competitor on Day 14. Not all media could sustain culture viability to the 21-day time point.
Dynamis Medium and ActiCHO P Medium had equivalent titer growth at day 14, in fed-batch culture, but Dynamis Medium had additional titer growth at day 18
An IgG-producing CHO-DG44 external cell line was cultured in Dynamis Medium and EfficientFeed C+ Supplement and other commercially available media and feeds for a period of up to 18 days. Titer values normalized to 100% to the best competitor on Day 18.
AchtiCHO could not sustain culture viability to the 18-day time point. Balance CD CHO was close to Dynamis Medium in titer growth, but required 3 times more the feeding volume.
Dynamis Medium enables faster cell growth, higher sustained cell concentrations and overall IVCD results in higher volumetric titers
DG44 IgG producing cell line, when supplemented with just glucose over 21 days, showed that Dynamis Medium growth profile is unsurpassed for peak densities and duration of culture against competitors. Dynamis Medium reaches 10 million cells/mL faster and maintains that level of high viable cell densities longer than the comparative products shown.
Growth performance of HEK293 in Dynamis Medium
HEK293 cells were seeded at 0.3 x 106 cells/mL in Dynamis Medium supplemented with 4 mM L-Glutamine and cultured in three 60 mL shake flasks (125 rpm, 37°C, 8% CO2). In all flasks, viable cell density (VCD) was measured on days 0, 1, 2, 3, 4, and 7. By day 7, glucose was depleted in the culture. Glucose level monitoring and supplementation (e.g., 2 g/L glucose) at the beginning of the culture or as a supplement on day 4 is recommended. The results show consistent high-density growth performance with HEK293 cells in Dynamis Medium
Dynamis Medium achieved 74% higher titer when compared to the next-best competitor, with glucose-only fed media
A IgG-producing internal CHO clone was cultured in Dynamis Medium or other commercially available media for a period of up to 21 days with glucose levels maintained via supplementation. Titer values were normalized to 100% to the best competitor on Day 14. Not all media could sustain culture viability to the 21-day time point.
Dynamis Medium and ActiCHO P Medium had equivalent titer growth at day 14, in fed-batch culture, but Dynamis Medium had additional titer growth at day 18
An IgG-producing CHO-DG44 external cell line was cultured in Dynamis Medium and EfficientFeed C+ Supplement and other commercially available media and feeds for a period of up to 18 days. Titer values normalized to 100% to the best competitor on Day 18.
AchtiCHO could not sustain culture viability to the 18-day time point. Balance CD CHO was close to Dynamis Medium in titer growth, but required 3 times more the feeding volume.
Dynamis Medium enables faster cell growth, higher sustained cell concentrations and overall IVCD results in higher volumetric titers
DG44 IgG producing cell line, when supplemented with just glucose over 21 days, showed that Dynamis Medium growth profile is unsurpassed for peak densities and duration of culture against competitors. Dynamis Medium reaches 10 million cells/mL faster and maintains that level of high viable cell densities longer than the comparative products shown.
For faster scale-up, try Dynamis Medium in our AGT dry media format. AGT format offers simply reconstitution and animal origin free (AOF), chemically defined properties that help streamline regulatory processes.
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