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Affinity Resins—Biosimilars and Recombinant Proteins
We have developed a unique portfolio of affinity resins to help you develop biosimilars, biobetters, and other types of recombinant proteins. These affinity resins can be used for clinical and commercial production.
CaptureSelect Affinity resin benefits:
- High selectivity─high purity in a single capture step, independent of feedstock
- Mild elution conditions─retention of biological activity of target
- Reduction of process steps─helps reduce costs, allows higher yields
- Efficient clearance of impurities
To complement each affinity resin, we offer product-specific ELISAs to measure any ligand potentially leaching from the column.
CaptureSelect affinity matrices:
| CaptureSelect Product | Resin characteristics |
|---|---|
Binds intact Follicle Stimulating Hormone (FSH) at the alpha/beta chain interface | |
Mild elution properties allowing gentle elution of albumin fusion proteins | |
Selectively binds human chorionic gonadotropin without cross reactivity to other gonadotropins such as FSH, LH, and TSH | |
Selective purification of HGH with retained activity of the protein | |
Binds Factor X and Factor Xa in the presence of calcium. Efficient purification with retained activity of the protein and no cross binding to other plasma proteins. | |
Binds tPA in the presence of magnesium chloride at neutral pH | |
Selectively binds TSH without cross reactivity to other gonadotropins such as FSH, LH, and HCG | |
Unique selectivity for the 4-amino acid tag: C-tag Used for the efficient purification of C-tagged proteins, i.e. vaccine development | |
Designed for the purification of human C1 esterase inhibitor from recombinant and plasma/serum sources Higher flowrates and efficient binding of larger biomolecules |
Quantitate the yield of your proteins during the production process with our analytical columns or develop your own analytical assay with CaptureSelect Ligand Conjugates.
When your specific process needs cannot be met with current products, our custom chromatography services are available to build you a unique solution. For more information, please visit Custom Capabilities.
CaptureSelect Leakage ELISAs
Products incorporating CaptureSelect technology are used for clinical and commercial manufacturing of a variety of biologics. To complement each affinity resin, we offer product specific ELISAs to measure any ligand potentially leaching from the column. Click on the product table below to see all available ELISAs.
These leakage ELISAs are developed to accompany Select resins.
Chromatography Learning Lab
Check out the new Chromatography Learning Lab from Thermo Fisher Scientific, providing a robust range of webinars, articles, eBooks, infographics, and other digital resources to help you optimize the use of our purification products in your process.
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