GeneArt Protein Expression and
Purification Services

Expand your capacity and expedite your protein and antibody discovery workflow. We've combined our R&D breakthroughs in gene synthesis, sequence optimization, and expression systems for services that can function as a flexible extension of your lab. You can outsource all or part of your protein expression and purification projects, with our scales supporting early discovery work through pilot studies and all the way up to 100 L+ production. Move from a target list to purified and documented protein in as little as 4 weeks with GeneArt gene-to-protein services.

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Advantages of selecting GeneArt Services:

• Higher yields—GeneOptimizer algorithm and optimized Expi mammalian expression systems
• Expert support—from consultation to ordering to delivery
• End-to-end speed—streamlined, fast production from gene synthesis to protein purification
• Support of early research and development of antibody therapeutics from small-scale screening to large-scale characterization

Service	HTP antibody expression	Mid-scale expression		Large-scale expression	Patheon Pharma Services
Target yields*	100 ug–10 mg	>10 mg		>1 g	Kilograms
Expression volumes	2.5 mL (24-well plates)	30–40 mL	100 mL,1–25 L	25+ L	Cell line development
Production time	≤20 business days	4–5 weeks			Defined in statement of work
Ideal for	Mass spectrometry, functional testing, structural studies, and further characterization		Toxicity and safety	Preclinical planning	Therapeutic grade

*Target yields are approximate for the expression volumes and depend on variables including exact sequence and vector

GeneArt Services help maximize protein expression and cost efficiency by optimizing at every step. It starts on a foundation of sequence optimization, choosing codon sequences customized for the desired expression system. Compound that with media and cells that allow for higher cell densities, high per-cell productivity, and high-efficiency transfection for expression yields up to 3 g/L. Taken together, the result is higher protein yields from the same culture volume.

Figure 1. Cloning and protein expression workflow using GeneArt Gene Synthesis services. Our workflows are available (A) without or (B) with proprietary GeneOptimizer software to optimize wild type sequences to improve cloning efficiencies and protein expression levels.

Learn how the GeneOptimizer algorithm was developed to improve protein expression

Our protein expression and purification services utilize commercially available Gibco ExpiCHO and Expi293 Expression systems, enabling you to seamlessly work between your bench and our productions labs.

These rapid, high-yield production systems based on high density cultures and powered by proven transfection reagents are a trusted staple in many labs expressing drug candidates.

From start to finish, every protein project is powered by a team of expert technical project managers. Whether you know exactly what you need or would prefer consultation to help achieve your goals, support is tailored for your specific requirements. Benefit from our experience to help accelerate your standard expression projects and provide guidance for more complex protocols, when needed.

Ready to request a quote or reach out to our project team? Start here