Gene Expression Analysis

Gene expression analysis simultaneously compares the RNA expression levels of multiple genes (profiling) and/or multiple samples (screening). This analysis can help scientists identify the molecular basis of phenotypic differences and to select gene expression targets for in-depth study.

Gene expression analysis by real-time PCR

Real-time PCR is the gold-standard technique for verification of differential gene expression profiles. Our comprehensive offering of TaqMan Gene Expression Assays and flexible formats enables fast and cost-effective results.

• TaqMan Gene Expression Assays
• TaqMan Gene Expression Assays in cards and plates for verification and screening
• OpenArray technology for profiling, verification, and research screening
• Recommended real-time PCR reagents
• QuantStudio real-time PCR instrument portfolio

Gene expression profiling by microarray

Microarrays are designed with up-to-date content from public sequence data sources, and enable fast, detailed transcriptome-wide expression profiling, even from challenging and precious samples with no bioinformatics resources required.

• Clariom  D Assays for analysis of genes, long noncoding RNA, exons, and splice variants
• Clariom S Assays for robust profiling of well-annotated genes
• Clariom GO Screen for high-throughput secondary screening of drug compounds
• Transcriptome Analysis Console (TAC) Software for analysis
• Learn more about our affordable transcriptome profiling services
• See our microarray instruments

Gene expression profiling by sequencing

Transcriptome sequencing by next-generation sequencing enables the discovery of differentially expressed genes using a hypothesis-neutral approach.         

• Whole-transcriptome RNA-Seq
• Targeted RNA sequencing
• Small RNA sequencing
• Ion GeneStudio S5 series of instruments

Gene expression profiling by hybridization-based assay

Multiplex hybridization-based assays utilize a branched DNA technology for signal amplification for the direct quantitation of gene expression transcripts. These assays are designed to quantitatively measure RNA directly from cell or tissue homogenates without RNA purification or enzymatic manipulation.

• QuantiGene Plex RNA assays

Gene expression quantification by digital PCR

Digital PCR enables highly precise measurements and is able to resolve gene expression level changes of two-fold or less. Digital PCR can also be used to determine the absolute quantification of a transcript without the need for a reference gene.

• QuantStudio 3D Digital PCR System
• Digital PCR applications

Drug discovery and development

Expand your capabilities with our outsourced services and an extensive product catalog supporting the entire pharmaceutical development process.

• Outsourced screening and profiling services
• Custom assay development
• Cell line engineering services
• ADME/Tox testing
• Hepatocytes, kupffer cells, and stellate cells