Vanquish HPLC and UHPLC Systems

Precision high-performance LC instruments

Robust, reliable and with unmatched retention time precision. Learn how our award-winning Thermo Scientific Vanquish HPLC and UHPLC instruments can help you unlock substantial productivity gains and save you money.

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Why should you choose our Vanquish LC Systems?

Choosing Vanquish LC Systems will allow you to maximize productivity, save over $5K per year on instrument costs, and generate higher-quality results. With components built to last, you can spend less money on unplanned repairs and advance your science beyond today’s boundaries.

Our Vanquish LC Systems offer you:

Enhanced, no-compromise performance to keep you ahead of future demands
Improved productivity and simple operation to accelerate your work
Versatile platforms to open up new analytical opportunities
Higher robustness and data quality to help maintain compliance
Third-party CDS compatibility to make integrating new technology easier

See how award-winning HPLC technology from Thermo Fisher Scientific continues to advance the science of separations.

Are you ready to love your LC instrument?

The launch of our Vanquish Horizon UHPLC System in 2014 and subsequent expansion of this portfolio led to a new generation of robust and reliable instruments enabling chromatographers to explore unrealized analytical opportunities. With unmatched reliability and retention time precision, it’s no surprise to hear how much our customers really do love their Vanquish LC Systems.

I love my Vanquish HPLC so much because its performance is so reliable. During the pandemic, we didn't get a chance to work on it, and it was turned off for over a year. But after we returned to the lab, we did quick routine maintenance and injected some QC samples. The retention times of the standards aligned SO WELL with previous QCs. I was absolutely in awe of the reproducibility. I would definitely recommend Vanquish to my colleagues.
— Harong L. | Academia

My Vanquish UHPLC, named Cynthia, has been a fantastic addition to my lab space. Fast run times, robust methodology, and the ease of use for Chromeleon makes Cynthia a vital part of my lab team!
— Bjorn L. | Beauty Counter

See all the reasons why our customers say I #LoveMyVanquish.

Green is our new HPLC standard

Enabling our customers to make the world healthier, cleaner and safer is at the heart of every colleague at Thermo Fisher Scientific . And thanks to our leadership, we have an actionable science-based plan for the company to achieve net-zero emissions by 2050.

Our most outstanding climate-friendly achievements to date center around the Germering, Germany plant where we develop and manufacture our Vanquish LC Systems. In fact, this location is our FIRST site fully powered by renewable energy!

We aim to accomplish much more than just clean energy at a single site, as you can see in our net-zero development plan and our HPLC sustainability fact sheet.

Meet our Vanquish HPLC & UHPLC Systems

Our base Vanquish LC Systems covers a wide range of pressure and flow ranges to meet your analytical and performance requirements. We also offer several application-specific systems to help you tackle more unique separation needs.

Related HPLC pages

Typical applications
Vanquish Core HPLC Systems	Vanquish Flex UHPLC Systems	Vanquish Horizon UHPLC Systems	Vanquish Neo UHPLC System
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A dependable workhorse for your traditional or routine QA/QC analysis. Vanquish Core HPLC Systems empower your operators to deliver continuous results by removing disruptions in analyses	Gain the flexibility to run HPLC and UHPLC analyses on a single system. Vanquish Flex UHPLC Systems offer you flexible method development to accommodate all applications	Get unmatched ultra-high performance and throughput for your most difficult samples. Vanquish Horizon UHPLC Systems allow you to run smaller particles and column dimensions with confidence	Achieve your next scientific breakthrough with next-generation low-flow technology. Vanquish Neo UHPLC Systems deliver robust separations 24/7 to support your high-sensitivity LC-MS workflows
Pump options
Binary, Quaternary, Dual and Isocratic	Binary, Quaternary and Dual	Binary	Binary
System pressure
Up to 700 bar	Up to 1000 bar	Up to 1500 bar	Up to 1500 bar
Flow range
0.001 - 10 mL/min	0.001 - 8 mL/min	0.001 - 5 mL/min	1 nL/min - 100 μL/min
Biocompatible
No	Yes	Yes	Yes
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Application-specific Vanquish LC systems

Our application-specific LC instruments can help you maximize productivity, sample knowledge and purity, or optimize methods. You can build dedicated instruments for specific applications by mixing components of our base Vanquish LC Systems.

System feature
Vanquish Duo HPLC & UHPLC Systems	Vanquish Online 2D-LC Systems	Vanquish Analytical Purification LC Systems	Vanquish Method Development System
Uses a second pump to maximize your productivity or quantification capabilities compared to a single-channel instrument	Employs multidimensional separations to improve your analysis of complex samples or simplify the separation of difficult-to-resolve analytes	Combines precise LC separation powers with high-performance fractionation capabilities to deliver you ultra-pure products	Accelerate and optimize your separation conditions with automation by testing different combinations of buffers on up to six columns
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	Systems built from Vanquish Core HPLC components	Systems built from Vanquish Flex UHPLC components	Systems built from Vanquish Horizon UHPLC components
Vanquish Duo for Dual LC
Vanquish Duo for Dual LC-MS
Vanquish Duo for Tandem LC or LC-MS
Vanquish Duo for Inverse Gradient LC
Vanquish Online SPE Systems
Vanquish Loop Heart-Cut 2D-LC Systems
Vanquish Trap Heart-Cut 2D-LC Systems
Vanquish Simple Switch 2D-LC Systems
Vanquish Method Development Systems