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Solutions for oligonucleotide therapeutic analysis
Thermo Fisher Scientific offers a comprehensive range of optimized analytical solutions to support the development of oligonucleotide therapeutics. These solutions are tailored to provide essential information at each stage of drug development, accelerating the path to market. Leveraging our class-leading technologies and products, we address the diverse needs of oligonucleotide therapeutics development.
Structural characterization of oligonucleotide therapeutics involves determining the molecular structure and conducting sequence conformation of the oligonucleotide molecules. This information is crucial for understanding their functional properties, interactions with target molecules, and potential therapeutic effects.
Mass Spectrometry (MS) offers unique benefits for oligonucleotide structural characterization due to its exceptional accuracy, sensitivity, and selectivity.
Accurate identification and quantification of impurities in oligonucleotide therapeutics play a pivotal role in ensuring their safety and efficacy. Impurities can originate from several sources, such as incomplete synthesis, side reactions during manufacturing, and/or degradation over time.
By leveraging the unique benefits of LC-MS approaches, researchers and manufacturers can effectively identify and quantify impurities in oligonucleotide therapeutics, ensuring the safety, quality, and efficacy.
By implementing compliance ready robust routine monitoring and quality control procedures, manufacturers can ensure the consistent quality, safety, and efficacy of oligonucleotide therapeutics throughout their lifecycle.
LC-UV and LC-MS approaches offer distinct benefits for routine monitoring and quality control of oligonucleotide therapeutics.
DMPK and bioanalysis studies provide valuable data on the pharmacokinetics, metabolism, and bioavailability of oligonucleotide therapeutics, aiding in their optimization, safety assessment, and clinical development.
LC-MS contributes to a deeper understanding of the therapeutic agent's behavior in biological systems.
For Research Use Only. Not for use in diagnostic procedures.