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Comprehensive solutions to support CAR T-cell therapy research from T-cell engineering to sequencing
Adoptive cell transfer is a rapidly emerging area of immuno-oncology research. This approach involves collecting, manipulating, activating, and transferring a subject’s immune cells to treat cancer. A widely studied approach to cell therapy is chimeric antigen receptor T-cell therapy, also known as CAR T-cell therapy.
Many immuno-oncology therapeutics are mass-produced antibody or fusion proteins. CAR T-cell therapy breaks that mold by utilizing a genetically modified patient T cell that attacks and kills the cancer cells. T cells do not normally identify cancer cells as foreign bodies, which would mark them for destruction. For immunotherapy to work, T cells are genetically manipulated to enable them to identify the cancer cells as an enemy and kill them as they would other foreign bodies. The T cells are genetically modified with CARs containing antibody-based recognition domains directed against cell-surface antigens linked to intracellular signaling sequences to overcome the cancer cell’s tolerance. Once created, these modified T cells are reintroduced into the subject along with chemotherapy.
Analyzing the immune repertoire to capture the diversity of T-cell receptor (TCR) rearrangements can help you make significant progress in immuno-oncology research (Figure 1). Explore workflow solutions from engineering to sequencing through cell media and reagents.
Our Gibco Cell Therapy Systems (CTS) products facilitate a seamless transition from research to commercialization.
Designed to measure T-cell diversity and clonal expansion by sequencing T-cell receptor beta chain rearrangements
Discover the only complete genome-editing solution designed to expedite your CAR T-cell research with less effort.
Learn more about our sequencing solutions including NGS and Sanger sequencing.
We offer quality Invitrogen immunoassays designed to help you easily quantify checkpoint protein biomarkers with confidence.
Find tools and reagents needed for T-cell engineering and manipulation.
Leverage magnetic beads and reagents, trusted solutions for ex vivo T cell isolation, activation, and expansion for immunotherapy.
Automated, highly accurate cell counting to minimize variability with the Countess II FL Automated Cell Counter.
From isolation and activation to 3D cellular assays, learn more about CAR T cell and other adoptive cell therapy workflows.
The Immuno-Oncology Product Resource Guide is an introduction to immuno-oncology research, covering key approaches such as CAR T-cell therapy research and solutions for each application area.
For Research Use Only. Not for use in diagnostic procedures.