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ChIP-on-chip (location analysis) is a powerful microarray-based method for analyzing epigenetic modifications and DNA sequences bound to specific regulatory proteins. Briefly, in ChIP-on-chip protein-DNA complexes are crosslinked, immunoprecipitated, purified, amplified and labeled and then allowed to hybridize to a variety of high resolution arrays. Invitrogen has developed cost-effective products to overcome challenges facing ChIP microarray researchers – notably higher yields without increase non specific binding and more representative amplification.
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