Nucleic Acid Sample Preparation Solutions | Thermo Fisher Scientific

Wide range of sample preparation solutions

Insufficient nucleic acid extraction is the most common cause of molecular workflow issues in commercial supply, so make sure you are using the right products. Bead-based solutions avoid the use of organic solvents or nucleic acid precipitation, helping to eliminate the problems often encountered with filter-based nucleic acid isolation methods.

For your unique assay or application, we offer a wide range of sample preparation solutions, including Invitrogen Dynabeads magnetic beads, which are customizable for your workflow, or turnkey Applied Biosystems MagMAX kits, which are optimized for easy integration. Both Dynabeads and MagMAX kits work seamlessly with Thermo Scientific KingFisher automation instruments for high-throughput genomic analysis. For more unique or demanding applications, our R&D scientists will work closely with you to customize our beads and buffers to your exact specifications.

Take no chances in the effort to achieve your goals. Partner with us for the quality, security of supply, customization, and expertise you can expect from the world leader in serving science.

Dynabeads magnetic beads

Dynabeads products offer many unique benefits and are widely used for specific capture and detection of nucleic acids in clinical samples. Some of the products are from our existing bio-discovery portfolio, while others are developed and supplied on an OEM basis. Our beads are monodisperse, with tight CV (coefficient of variation) specifications and exceptional batch-to-batch reproducibility.

In addition to a broad portfolio of off-the-shelf Dynabeads products, our patented technology and proprietary knowledge enable customized product development.

Customization may include:

Coupling of antibody, protein, nucleic acid, or other bioreactive ligands
Chemical groups and surface functionality
Iron content and magnetic characteristics
Bead size, polymer, and pore structure

Dynabeads for nucleic acid purification

Capture	Dynabeads	Surface	Bead size	Characteristics
Generic	MyOne SILANE	Silica-like	1.1 µm	Rare or abundant target capture High-efficiency capture Generic en-masse purification
Generic	MyOne Carboxylic Acid	Hydrophilic	1.1 µm	High efficiency capture Generic en-masse purification
Specific	MyOne Carboxylic Acid	Hydrophilic	1.1 µm	Oligonucleotide coupling
Generic	M-270 Carboxylic Acid	Hydrophilic	2.8 µm	High efficiency capture Generic en-masse purification
Specific	M-270 Carboxylic Acid	Hydrophilic	2.8 µm	Oligonucleotide coupling
Specific	MyOne Streptavidin C1	Hydrophilic	1.1 µm	High surface-to-volume ratio Fast kinetics Slow sedimentation Isolation and handling of biotinylated targets Direct or indirect capture of target nucleic acid Use of biotinylated oligos
Specific	MyOne Streptavidin T1	Hydrophilic	1.1 µm	High surface-to-volume ratio Fast kinetics Slow sedimentation Isolation and handling of biotinylated targets Direct or indirect capture of target nucleic acid Use of biotinylated oligos
Specific	M-270 Streptavidin	Hydrophilic	2.8 µm	Normally low background Isolation and handling of biotinylated targets Direct or indirect capture of target nucleic acid Use of biotinylated oligos
Specific	M-280 Streptavidin	Hydrophobic	2.8 µm	Isolation and handling of biotinylated targets Direct or indirect capture of target nucleic acid Use of biotinylated oligos
Specific	Oligo(dT)₂₅(M-270)	Hydrophilic	2.8 µm	mRNA (poly A) capture

MagMAX reagents

MagMAX kits offer a turnkey solution for nucleic acid purification for your application, including pathogen detection and formalin-fixed, paraffin-embedded (FFPE) solid tumor biopsies. The MagMAX solution is an integrated system designed to simplify, standardize, and accelerate preparation of samples derived from various sources for downstream molecular analysis.

MagMAX kits for nucleic acid purification

	Nucleic acid isolated	Application	Features	Sample types
MagMAX mirVana Total RNA Isolation Kit	True total RNA (small RNA– enriched total RNA)	RNA-based oncology or infectious disease testing	Works with most samples of interest, including plasma, serum, whole blood, cell culture, tissue, and urine	No need to buy multiple kits to work with specific samples Phenol-free (no organic extraction) Verified for use with TaqMan® Advanced miRNA Assays
MagMAX DNA MultiSample Ultra 2.0 Kit	Genomic DNA	Genotyping for inherited disease, oncology, and infectious disease testing	Compatible with common sample types (whole blood, tissue, saliva, buccal swabs, and oral rinse)	Streamlined protocols for numerous noninvasive biological samples
MagMAX Cell-Free DNA Isolation Kit	Cell-free DNA	Noninvasive prenatal testing (NIPT), liquid biopsy	Whole blood	Can enrich for cell-free DNA fraction
MagMAX Cell-Free Total Nucleic Acid Isolation Kit	Cell-free DNA and RNA	NIPT, liquid biopsy	Whole blood	Enrichment of all nucleic acid species present in cell-free biological samples such as plasma
MagMAX FFPE DNA/RNA Ultra Kit	DNA and RNA	Genotyping and gene expression for solid tumors	FFPE samples	No sample splitting (RNA and DNA from same FFPE section)
MagMAX Pathogen RNA/DNA Kit	RNA and DNA	Infectious disease testing	Serum and plasma; nasal, tracheal, and cloacal swabs; ear samples; whole blood; semen; oral fluid; feces	Purification from viruses and easy-to-lyse bacteria and parasites Low and high sample input volumes
MagMAX Saliva gDNA Isolation Kit	Genomic DNA	A variety of molecular protocols, particularly for direct-toconsumer testing	Saliva	Scalable and automatable protocol for the isolation of genomic DNA (gDNA) from fresh and stabilized saliva

KingFisher automation

KingFisher purification systems are designed to deliver high-quality results with minimal hands-on time, helping you automate a significant part of your workflow. KingFisher systems use permanent magnetic rods and disposable tip combs to collect, transfer and mix magnetic particles.

KingFisher Apex instrument

Watch the automated, medium- to high-throughput Thermo Scientific KingFisher Apex instrument operating to process sample preparation. Building on decades of KingFisher product value and excellence, the KingFisher Apex represents the pinnacle of automated purification for DNA, RNA, proteins, and cells.

KingFisher instruments for nucleic acid purification

KingFisher Duo Prime	KingFisher Flex	KingFisher Apex	KingFisher Presto

Semi-automated Fits on the bench 12–24 samples per run	Semi-automated 24–96 samples per run	Automated benchtop 1–96 samples per run	Fully automated Integrates with liquid handlers 24–96 samples per run (per instrument)

Dynabeads magnetic beads

Dynabeads magnetic beads

In addition to a broad portfolio of off-the-shelf Dynabeads products, our patented technology and proprietary knowledge enable customized product development.

Customization may include:

Coupling of antibody, protein, nucleic acid, or other bioreactive ligands
Chemical groups and surface functionality
Iron content and magnetic characteristics
Bead size, polymer, and pore structure

Dynabeads for nucleic acid purification

Capture	Dynabeads	Surface	Bead size	Characteristics
Generic	MyOne SILANE	Silica-like	1.1 µm	Rare or abundant target capture High-efficiency capture Generic en-masse purification
Generic	MyOne Carboxylic Acid	Hydrophilic	1.1 µm	High efficiency capture Generic en-masse purification
Specific	MyOne Carboxylic Acid	Hydrophilic	1.1 µm	Oligonucleotide coupling
Generic	M-270 Carboxylic Acid	Hydrophilic	2.8 µm	High efficiency capture Generic en-masse purification
Specific	M-270 Carboxylic Acid	Hydrophilic	2.8 µm	Oligonucleotide coupling
Specific	MyOne Streptavidin C1	Hydrophilic	1.1 µm	High surface-to-volume ratio Fast kinetics Slow sedimentation Isolation and handling of biotinylated targets Direct or indirect capture of target nucleic acid Use of biotinylated oligos
Specific	MyOne Streptavidin T1	Hydrophilic	1.1 µm	High surface-to-volume ratio Fast kinetics Slow sedimentation Isolation and handling of biotinylated targets Direct or indirect capture of target nucleic acid Use of biotinylated oligos
Specific	M-270 Streptavidin	Hydrophilic	2.8 µm	Normally low background Isolation and handling of biotinylated targets Direct or indirect capture of target nucleic acid Use of biotinylated oligos
Specific	M-280 Streptavidin	Hydrophobic	2.8 µm	Isolation and handling of biotinylated targets Direct or indirect capture of target nucleic acid Use of biotinylated oligos
Specific	Oligo(dT)₂₅(M-270)	Hydrophilic	2.8 µm	mRNA (poly A) capture

MagMAX reagents

MagMAX reagents

MagMAX kits for nucleic acid purification

	Nucleic acid isolated	Application	Features	Sample types
MagMAX mirVana Total RNA Isolation Kit	True total RNA (small RNA– enriched total RNA)	RNA-based oncology or infectious disease testing	Works with most samples of interest, including plasma, serum, whole blood, cell culture, tissue, and urine	No need to buy multiple kits to work with specific samples Phenol-free (no organic extraction) Verified for use with TaqMan® Advanced miRNA Assays
MagMAX DNA MultiSample Ultra 2.0 Kit	Genomic DNA	Genotyping for inherited disease, oncology, and infectious disease testing	Compatible with common sample types (whole blood, tissue, saliva, buccal swabs, and oral rinse)	Streamlined protocols for numerous noninvasive biological samples
MagMAX Cell-Free DNA Isolation Kit	Cell-free DNA	Noninvasive prenatal testing (NIPT), liquid biopsy	Whole blood	Can enrich for cell-free DNA fraction
MagMAX Cell-Free Total Nucleic Acid Isolation Kit	Cell-free DNA and RNA	NIPT, liquid biopsy	Whole blood	Enrichment of all nucleic acid species present in cell-free biological samples such as plasma
MagMAX FFPE DNA/RNA Ultra Kit	DNA and RNA	Genotyping and gene expression for solid tumors	FFPE samples	No sample splitting (RNA and DNA from same FFPE section)
MagMAX Pathogen RNA/DNA Kit	RNA and DNA	Infectious disease testing	Serum and plasma; nasal, tracheal, and cloacal swabs; ear samples; whole blood; semen; oral fluid; feces	Purification from viruses and easy-to-lyse bacteria and parasites Low and high sample input volumes
MagMAX Saliva gDNA Isolation Kit	Genomic DNA	A variety of molecular protocols, particularly for direct-toconsumer testing	Saliva	Scalable and automatable protocol for the isolation of genomic DNA (gDNA) from fresh and stabilized saliva

KingFisher automation

KingFisher automation

KingFisher Apex instrument

KingFisher instruments for nucleic acid purification

KingFisher Duo Prime	KingFisher Flex	KingFisher Apex	KingFisher Presto

Semi-automated Fits on the bench 12–24 samples per run	Semi-automated 24–96 samples per run	Automated benchtop 1–96 samples per run	Fully automated Integrates with liquid handlers 24–96 samples per run (per instrument)

For Research Use Only. Not for use in diagnostic procedures.

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Nucleic Acid Extraction

Wide range of sample preparation solutions

Dynabeads magnetic beads

Dynabeads for nucleic acid purification

MagMAX kits for nucleic acid purification

KingFisher Apex instrument

KingFisher instruments for nucleic acid purification

Dynabeads magnetic beads

Dynabeads for nucleic acid purification

MagMAX kits for nucleic acid purification

KingFisher Apex instrument

KingFisher instruments for nucleic acid purification