Resources for Structure Based Drug Design with Cryo-EM

Shaping the future of therapeutics with AI

By delivering greater insight into protein sequence, structure, and function, artificial intelligence and machine learning make it possible to program novel medicines that can treat a variety of diseases.

In this webinar, Dr. Alex Snyder from Generate: Biomedicines covers:

• How generative AI is being leveraged to fill critical gaps in medical treatments by identifying and developing new drug targets
• The synergistic integration of computational (dry-lab) and experimental (wet-lab) approaches to accelerate the drug development pipeline, leading to more personalized and efficacious medical solutions

Cryo-electron microscopy is revolutionizing rational drug discovery pipelines

Rational design leveraging routine, high resolution protein structure determination is driving the discovery and development of diverse biologic and small molecule therapies. Cryo-EM delivers rapid epitope mapping on the atomic scale for antibody therapeutics and immune response profiling, supports elucidation of mechanism of action and is also enabling more therapeutic targets than ever before for Structure-Based Drug Design. Whether to modulate binding affinities or to optimize drug stability, all of these questions can be answered in just one day of data collection.

Watch the webinar to hear experts from Sanofi to discuss:

• An overview of how to quickly go from protein to structure
• Key examples of multi-specific drugs and structural insights of a CEACAM5-targeting antibody drug conjugate (ADC)
• How the adoption of Cryo-EM has significantly increased the number of the targets that can be identified for clinical trials in both biopharma and biotech

Generative AI: Turning drug discovery into a technological pursuit

Hear from Generate: Biomedicines to learn how generative AI has the capability to ultimately deliver medicines better tailored to specific patient conditions and unmet medical needs faster and cheaper than ever before.

Learn how Embedded CryoSPARC Live can support your single particle analysis by seamlessly integrating with your workflow to simplify operation, feeding Smart Plugins to automatically adjust data collection settings on the fly for higher data quality, providing real-time image analysis, and facilitating post processing.