The plastic and glass surfaces of pipette tips and tubes including PCR tubes, microcentrifuge tubes, and conical tubes, are an easily overlooked source of ribonuclease (RNase) contamination. Thermo Fisher offers a range of RNase-free plastics including pipette tips, PCR tubes, microcentrifuge tubes, and conical tubes. Each lot of Invitrogen brand tips and tubes undergoes rigorous testing to ensure that they are nuclease-free (RNase- and DNase-free).

Basics of RNase control Working with RNA

RNase-free, nuclease-free tips and tubes

RNase-free, nuclease-free lab supplies are essential in lab spaces where researchers work with RNA. Common lab supplies such as pipette tips, PCR tubes, microcentrifuge tubes, and conical tubes are offered in an RNase-free format.

RNase-free pipette tips

Invitrogen RNase-free Tips, 200 μL size product photo

For safe transfer of samples and reagents, RNase-free pipette tips come in two different formats: without a barrier/filter and with a barrier/filter (also known as barrier tips or filter tips). Both formats have the following features:

  • E-beam sterilized—nuclease-free and RNase-free
  • Autoclave-safe
  • Compatible with a broad range of pipettors

RNase-free PCR tubes

nvitrogen PCR tubes with caps, RNase-free, 0.2 mL (8-strip format) product photo

RNase-free PCR tubes are available in different varieties. RNase-free PCR tubes offer thinner walls to allow for better sample temperature regulation, as well as frosted surfaces for easy labeling. Other options include domed or flat caps, as well as 0.2 mL and 0.5 mL formats. Thermo Fisher RNase-free PCR tubes have the following features:

  • Certified nuclease-free and RNase-free
  • Allow uniform contact with the thermal cycler temperature block
  • Autoclave-safe

RNase-free microcentrifuge tubes

Invitrogen Nonstick, RNase-free Microfuge Tubes, 0.5 mL product photo

RNase-free microcentrifuge tubes are available in three different sizes (0.5 mL, 1.5 mL, and 2.0 mL) and have marked gradations for convenience. Our microcentrifuge tubes are lot tested for contaminants, such as nucleases including RNases and DNases. All our RNase-free microcentrifuge tubes have the following features:

  • Certified nuclease-free and RNase-free
  • Non-stick, low-binding surface
  • Positive-seal design that prevents caps from opening in boiling water baths
  • Autoclave-safe

RNase-free conical tubes for safe storage of samples and reagents from RNases

RNase-free conical tubes are available in two different sizes (15 mL and 50 mL) and have printed writing space and volume marks for convenience. Our RNase-free conical tubes have the following features:

  • Certified nuclease-free and RNase-free tubes come racked and are pre-assembled with green screw tops
  • Tubes come racked and are pre-assembled with green screw tops
  • Autoclave-safe
Tips

RNase-free pipette tips

Invitrogen RNase-free Tips, 200 μL size product photo

For safe transfer of samples and reagents, RNase-free pipette tips come in two different formats: without a barrier/filter and with a barrier/filter (also known as barrier tips or filter tips). Both formats have the following features:

  • E-beam sterilized—nuclease-free and RNase-free
  • Autoclave-safe
  • Compatible with a broad range of pipettors
PCR tubes

RNase-free PCR tubes

nvitrogen PCR tubes with caps, RNase-free, 0.2 mL (8-strip format) product photo

RNase-free PCR tubes are available in different varieties. RNase-free PCR tubes offer thinner walls to allow for better sample temperature regulation, as well as frosted surfaces for easy labeling. Other options include domed or flat caps, as well as 0.2 mL and 0.5 mL formats. Thermo Fisher RNase-free PCR tubes have the following features:

  • Certified nuclease-free and RNase-free
  • Allow uniform contact with the thermal cycler temperature block
  • Autoclave-safe
Microcentrifuge tubes

RNase-free microcentrifuge tubes

Invitrogen Nonstick, RNase-free Microfuge Tubes, 0.5 mL product photo

RNase-free microcentrifuge tubes are available in three different sizes (0.5 mL, 1.5 mL, and 2.0 mL) and have marked gradations for convenience. Our microcentrifuge tubes are lot tested for contaminants, such as nucleases including RNases and DNases. All our RNase-free microcentrifuge tubes have the following features:

  • Certified nuclease-free and RNase-free
  • Non-stick, low-binding surface
  • Positive-seal design that prevents caps from opening in boiling water baths
  • Autoclave-safe
Conical tubes

RNase-free conical tubes for safe storage of samples and reagents from RNases

RNase-free conical tubes are available in two different sizes (15 mL and 50 mL) and have printed writing space and volume marks for convenience. Our RNase-free conical tubes have the following features:

  • Certified nuclease-free and RNase-free tubes come racked and are pre-assembled with green screw tops
  • Tubes come racked and are pre-assembled with green screw tops
  • Autoclave-safe
Resources

TechNotes articles

Support
CMD Wide-format style fixes

For Research Use Only. Not for use in diagnostic procedures.

Stylesheet for Classic Wide Template adjustments
Stylesheet for Classic Wide Template adjustments
Hero banner dark gradient overlay