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ABI2 may act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. ABI2 is a part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. It regulates ABL1/c-Abl-mediated phosphorylation of MENA.
8430425M24Rik; Abelson interactor 2; Abi2; abi-2; ABI2B; abl binding protein 3; abl interactor 2; Abl-binding protein 3; AblBP3; abl-interacting protein 1 (SH3-containing protein); abl-interactor 2; abl-interactor protein 2b; AI839867; AIP-1; arg protein tyrosine kinase-binding protein; arg-binding protein 1; ArgBP1; ARGBPIA; argBPIB; C130078H13; SSH3BP2; thyroid hormone responsive protein
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