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ATG14 (Autophagy related protein homolog 14) is encoded by the ATG14 gene and is located on chromosome 14 in humans. It is also known as ATG14L or BARKOR (Beclin 1-associated autophagy-related key regulator). Autophagy is an evolutionarily conserved process that involves recycling of misfolded cellular proteins and degradation of dysfunctional organelles. Autophagy is induced as a cellular response to nutrient stress which includes the formation of autophagosomes, fusion of these with the lysosome and formation of the autophagolysosome. The Class III PI3-Kinase, Vps34 and its interacting partner Beclin 1 have been shown to form a complex which specifically includes ATG 14 (type 1) or UVRAG (type 2). Atg 14 guides the type 1 complex to the preautophagosomal structure (PAS) and is critical for the initiation of autophagosome formation.
4832427M01; Atg14; ATG14 autophagy related 14 homolog; Atg14L; Atg14-like protein; autophagy related 14; autophagy-related protein 14-like protein; Bakor; Barkor; beclin 1-associated autophagy-related key regulator; Beclin 1-Interacting protein; D14Ertd114e; D14Ertd436e; Kiaa0831; RGD1304610; VATG14 autophagy related 14 homolog
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