Product References
Tnpo3 controls splicing of the pre-mRNA encoding the canonical TCR α chain of iNKT cells.
Nature communications
Iwanami N,Richter AS,Sikora K,Boehm T
11-5711-82 was used in Flow cytometry/Cell sorting to identify a role for Tnpo3 in regulating the splicing of the pre-mRNA encoding the cognate TCRα chain of iNKT cells.
Tue Jun 20 00:00:00 EDT 2023
A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts.
Immunity
Zindl CL,Witte SJ,Laufer VA,Gao M,Yue Z,Janowski KM,Cai B,Frey BF,Silberger DJ,Harbour SN,Singer JR,Turner H,Lund FE,Vallance BA,Rosenberg AF,Schoeb TR,Chen JY,Hatton RD,Weaver CT
11-5711-82 was used in Flow cytometry/Cell sorting to demonstrate spatiotemporal differences in the production and action of IL-22 by ILCs and T cells during infection and reveal an indispensable role for IL-22-producing T cells in the protection of the intestinal crypts.
Tue Mar 08 00:00:00 EST 2022
Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells.
Immunity
Shmuel-Galia L,Humphries F,Lei X,Ceglia S,Wilson R,Jiang Z,Ketelut-Carneiro N,Foley SE,Pechhold S,Houghton J,Muneeruddin K,Shaffer SA,McCormick BA,Reboldi A,Ward D,Marshak-Rothstein A,Fitzgerald KA
11-5711-82 was used in Flow cytometry/Cell sorting to suggest a positive feedback loop wherein dysbiosis foments the accumulation of STING in intestinal myeloid cells, driving intestinal inflammation.
Tue Jun 08 00:00:00 EDT 2021
Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection.
Nature communications
Filtjens J,Roger A,Quatrini L,Wieduwild E,Gouilly J,Hoeffel G,Rossignol R,Daher C,Debroas G,Henri S,Jones CM,Malissen B,Mackay LK,Moqrich A,Carbone FR,Ugolini S
Published figure using TCR gamma/delta monoclonal antibody (Product # 11-5711-82) in Flow Cytometry
Tue May 18 00:00:00 EDT 2021
A road map from single-cell transcriptome to patient classification for the immune response to trauma.
JCI insight
Chen T,Delano MJ,Chen K,Sperry JL,Namas RA,Lamparello AJ,Deng M,Conroy J,Moldawer LL,Efron PA,Loughran P,Seymour C,Angus DC,Vodovotz Y,Chen W,Billiar TR
11-5711-82 was used in Flow cytometry/Cell sorting to provide the landscape of transcriptomic changes at the single-cell level after systemic injury.
Mon Jan 25 00:00:00 EST 2021
Hyperforin Ameliorates Imiquimod-Induced Psoriasis-Like Murine Skin Inflammation by Modulating IL-17A-Producing γδ T Cells.
Frontiers in immunology
Zhang S,Zhang J,Yu J,Chen X,Zhang F,Wei W,Zhang L,Chen W,Lin N,Wu Y
11-5711-82 was used in Flow Cytometry to provide a novel therapeutic tragedy for psoriasis by which hyperforin attenuates psoriasis-related inflammatory responses.
Wed Sep 22 00:00:00 EDT 2021
Sex-specific adipose tissue imprinting of regulatory T cells.
Nature
Vasanthakumar A,Chisanga D,Blume J,Gloury R,Britt K,Henstridge DC,Zhan Y,Torres SV,Liene S,Collins N,Cao E,Sidwell T,Li C,Spallanzani RG,Liao Y,Beavis PA,Gebhardt T,Trevaskis N,Nutt SL,Zajac JD,Davey RA,Febbraio MA,Mathis D,Shi W,Kallies A
11-5711-82 was used in Flow Cytometry to find that sex-specific differences in Treg cells from visceral adipose tissue are determined by the tissue niche in a sex-hormone-dependent manner to limit adipose tissue inflammation.
Sun Mar 01 00:00:00 EST 2020
Lymphocyte-Specific Function of the DNA Polymerase Epsilon Subunit Pole3 Revealed by Neomorphic Alleles.
Cell reports
Siamishi I,Iwanami N,Clapes T,Trompouki E,O'Meara CP,Boehm T
11-5711 was used in Flow cytometry/Cell sorting to serve as a paradigm to understand the molecular basis of cell-type-specific non-replicative functions of the ubiquitous POLE complex.
Tue Jun 16 00:00:00 EDT 2020
Epigenetic Protection of Vertebrate Lymphoid Progenitor Cells by Dnmt1.
iScience
Iwanami N,Takeshita K,Lawir DF,Suetake I,Tajima S,Sikora K,Trancoso I,ÓMeara C,Siamishi I,Takahama Y,Furutani-Seiki M,Kondoh H,Yonezawa Y,Schorpp M,Boehm T
11-5711 was used in Flow cytometry/Cell sorting to identify new recessive dnmt1 alleles in medaka and zebrafish and, guided by the structures of mutant proteins, generated a recessive variant of mouse Dnmt1.
Fri Jul 24 00:00:00 EDT 2020
Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria.
Cell host & microbe
Leech JM,Dhariwala MO,Lowe MM,Chu K,Merana GR,Cornuot C,Weckel A,Ma JM,Leitner EG,Gonzalez JR,Vasquez KS,Diep BA,Scharschmidt TC
11-5711-82 was used in Flow cytometry/Cell sorting to study how skin colonization by commensal Staphylococcus epidermidis facilitates immune tolerance preferentially in neonates via induction of antigen-specific regulatory T cells.
Wed Dec 11 00:00:00 EST 2019
Inhibition of phosphodiesterase-4 attenuates murine ulcerative colitis through interference with mucosal immunity.
British journal of pharmacology
Li H,Fan C,Feng C,Wu Y,Lu H,He P,Yang X,Zhu F,Qi Q,Gao Y,Zuo J,Tang W
11-5711 was used in Flow cytometry/Cell sorting to demonstrate that inhibition of PDE4 by apremilast protected against ulcerative colitis, by interfering with mucosal immunity in mice.
Mon Jul 01 00:00:00 EDT 2019
Aryl hydrocarbon receptor activation modulates γδ intestinal intraepithelial lymphocytes and protects against ischemia/reperfusion injury in the murine small intestine.
Molecular medicine reports
Zhang Z,Pu A,Yu M,Xiao W,Sun L,Cai Y,Yang H
11-5711-82 was used in Flow cytometry/Cell sorting to suggest that the AhR plays an important role in protecting the small intestine from I/R and increasing the γδIEL population by decreasing apoptosis of γδIELs.
Fri Mar 01 00:00:00 EST 2019
Protective role of γδ T cells in cigarette smoke and influenza infection.
Mucosal immunology
Hong MJ,Gu BH,Madison MC,Landers C,Tung HY,Kim M,Yuan X,You R,Machado AA,Gilbert BE,Soroosh P,Elloso M,Song L,Chen M,Corry DB,Diehl G,Kheradmand F
Published figure using TCR gamma/delta monoclonal antibody (Product # 11-5711-82) in Flow Cytometry
Tue May 01 00:00:00 EDT 2018
Group 2 innate lymphoid cells protect lung endothelial cells from pyroptosis in sepsis.
Cell death & disease
Lai D,Tang J,Chen L,Fan EK,Scott MJ,Li Y,Billiar TR,Wilson MA,Fang X,Shu Q,Fan J
11-5711 was used in Flow cytometry/Cell sorting to describe the function of ILC2 in the regulation of lung inflammation by protecting lung endothelial cell from pyroptosis.
Tue Mar 06 00:00:00 EST 2018
Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation.
Nature communications
Li H,Yao Q,Mariscal AG,Wu X,Hülse J,Pedersen E,Helin K,Waisman A,Vinkel C,Thomsen SF,Avgustinova A,Benitah SA,Lovato P,Norsgaard H,Mortensen MS,Veng L,Rozell B,Brakebusch C
11-5711 was used in Flow cytometry/Cell sorting to show that keratinocyte-produced IL-23 is sufficient to cause a chronic skin inflammation with an IL-17 profile in mice.
Thu Apr 12 00:00:00 EDT 2018
HVEM and CD160: Regulators of Immunopathology During Malaria Blood-Stage.
Frontiers in immunology
Muscate F,Stetter N,Schramm C,Schulze Zur Wiesch J,Bosurgi L,Jacobs T
11-5711 was used in Flow cytometry/Cell sorting to study the requirement of the co-stimulatory molecule HVEM to maintain CD8+ T effector populations during malarial infection.
Thu Oct 03 00:00:00 EDT 2019
Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin.
Cell host & microbe
Scharschmidt TC,Vasquez KS,Pauli ML,Leitner EG,Chu K,Truong HA,Lowe MM,Sanchez Rodriguez R,Ali N,Laszik ZG,Sonnenburg JL,Millar SE,Rosenblum MD
11-5711 was used in Flow cytometry/Cell sorting to show that hair follicle (HF) development facilitates the accumulation of regulatory T cells in neonatal skin and that upon skin entry these cells localise to HFs.
Wed Apr 12 00:00:00 EDT 2017
Differential effect of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) on leukocyte infiltration during contact hypersensitivity responses.
PeerJ
Early M,Schroeder WG,Unnithan R,Gilchrist JM,Muller WA,Schenkel A
Mon Dec 14 00:00:00 EST 2020
Enrichment of IFN-γ producing cells in different murine adipose tissue depots upon infection with an apicomplexan parasite.
Scientific reports
Teixeira L,Marques RM,Ferreirinha P,Bezerra F,Melo J,Moreira J,Pinto A,Correia A,Ferreira PG,Vilanova M
11-5711 was used in Flow cytometry/Cell sorting to investigate the contribution of NK and T cells to the production of IFN-γ in the adipose tissue of Neospora caninum infected mice.
Tue Mar 22 00:00:00 EDT 2016
Seminal plasma induces inflammation in the uterus through the γδ T/IL-17 pathway.
Scientific reports
Song ZH,Li ZY,Li DD,Fang WN,Liu HY,Yang DD,Meng CY,Yang Y,Peng JP
11-5711 was used in Flow cytometry/Cell sorting to identify a new mechanism by which seminal plasma could influence inflammation in the uterus through the γδ T/IL-17 pathway.
Mon Apr 25 00:00:00 EDT 2016
Intestinal Microbiota Promotes Psoriasis-Like Skin Inflammation by Enhancing Th17 Response.
PloS one
Zákostelská Z,Málková J,Klimešová K,Rossmann P,Hornová M,Novosádová I,Stehlíková Z,Kostovčík M,Hudcovic T,Štepánková R,Jůzlová K,Hercogová J,Tlaskalová-Hogenová H,Kverka M
11-5711 was used in Flow cytometry/Cell sorting to investigate the link between gut microbiota, T cells and the formation of psoriatic lesions in a mouse model of psoriasis.
Wed Jul 26 00:00:00 EDT 2017
The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote T(H)17 cell-dependent emphysema.
Nature immunology
Lu W,You R,Yuan X,Yang T,Samuel EL,Marcano DC,Sikkema WK,Tour JM,Rodriguez A,Kheradmand F,Corry DB
11-5711 was used in Flow cytometry/Cell sorting to show that miR-22 expression was upregulated as a consequence of smoking and contributes to the development of emphysema.
Sun Nov 01 00:00:00 EDT 2015
Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema.
eLife
You R,Lu W,Shan M,Berlin JM,Samuel EL,Marcano DC,Sun Z,Sikkema WK,Yuan X,Song L,Hendrix AY,Tour JM,Corry DB,Kheradmand F
11-5711 was used in Flow cytometry/Cell sorting to show that insoluble nanoparticulate carbon black accumulates in human myeloid dendritic cells (mDCs) from emphysematous lung and in CD11c(+) lung antigen presenting cells of mice exposed to smoke.
Mon Oct 05 00:00:00 EDT 2015
IL-1 receptor type 2 suppresses collagen-induced arthritis by inhibiting IL-1 signal on macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Shimizu K,Nakajima A,Sudo K,Liu Y,Mizoroki A,Ikarashi T,Horai R,Kakuta S,Watanabe T,Iwakura Y
11-5711 was used in Flow cytometry/Cell sorting to investigate the role of the Interleukin-1 receptor type 2 (IL-1R2) as a regulator of arthritis, by acting specifically on macrophages as a decoy receptor for IL-1.
Wed Apr 01 00:00:00 EDT 2015
A genome-wide analysis identifies a notch-RBP-Jκ-IL-7Rα axis that controls IL-17-producing γδ T cell homeostasis in mice.
Journal of immunology (Baltimore, Md. : 1950)
Nakamura M,Shibata K,Hatano S,Sato T,Ohkawa Y,Yamada H,Ikuta K,Yoshikai Y
11-5711 was used in Flow cytometry/Cell sorting to investigate additional roles for the Notch axis in the homeostasis of γδ T cells.
Thu Jan 01 00:00:00 EST 2015
Mouse dental pulp stem cells support human umbilical cord blood-derived hematopoietic stem/progenitor cells in vitro.
Cell transplantation
Nakatsuka R,Matsuoka Y,Uemura Y,Sumide K,Iwaki R,Takahashi M,Fujioka T,Sasaki Y,Sonoda Y
11-5711 was used in Flow cytometry/Cell sorting to demonstrate that prospectively isolated murine PDGFRα and Sca-1 double-positive dental pulp stem cells could support primitive human CD34+ and CD34- hematopoietic stem cells in vitro.
Wed Sep 16 00:00:00 EDT 2015
IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2(+)Vγ6(+)γδ T cells.
Nature communications
Akitsu A,Ishigame H,Kakuta S,Chung SH,Ikeda S,Shimizu K,Kubo S,Liu Y,Umemura M,Matsuzaki G,Yoshikai Y,Saijo S,Iwakura Y
Published figure using TCR gamma/delta monoclonal antibody (Product # 11-5711-82) in Flow Cytometry
Thu Jun 25 00:00:00 EDT 2015
Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.
Nature communications
Zanvit P,Konkel JE,Jiao X,Kasagi S,Zhang D,Wu R,Chia C,Ajami NJ,Smith DP,Petrosino JF,Abbatiello B,Nakatsukasa H,Chen Q,Belkaid Y,Chen ZJ,Chen W
11-5711 was used in Flow cytometry/Cell sorting to investigate the link between neonatal antibiotic-mediated imbalance in microbiota and development of experimental psoriasis.
Tue Sep 29 00:00:00 EDT 2015
Essential role for autophagy in the maintenance of immunological memory against influenza infection.
Nature medicine
Chen M,Hong MJ,Sun H,Wang L,Shi X,Gilbert BE,Corry DB,Kheradmand F,Wang J
11-5711 was used in Flow cytometry/Cell sorting to demonstrate autophagy is essential for the survival of virus-specific memory B cells and maintenance of protective antibody responses.
Thu May 01 00:00:00 EDT 2014
Agonistic induction of PPARγ reverses cigarette smoke-induced emphysema.
The Journal of clinical investigation
Shan M,You R,Yuan X,Frazier MV,Porter P,Seryshev A,Hong JS,Song LZ,Zhang Y,Hilsenbeck S,Whitehead L,Zarinkamar N,Perusich S,Corry DB,Kheradmand F
11-5711 was used in Flow cytometry/Cell sorting to reveal a proinflammatory pathway, in which reduced PPARγ activity promotes emphysema.
Sat Mar 01 00:00:00 EST 2014
Microbiota modulate tumoral immune surveillance in lung through a γδT17 immune cell-dependent mechanism.
Cancer research
Cheng M,Qian L,Shen G,Bian G,Xu T,Xu W,Shen G,Hu S
11-5711 was used in Flow cytometry/Cell sorting to investigate the mechanism by which commensal bacteria modulate the efficiency of tumoral immune surveillance in mucosal tissues.
Fri Aug 01 00:00:00 EDT 2014
The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage.
Journal of immunology (Baltimore, Md. : 1950)
Lee PH,Puppi M,Schluns KS,Yu-Lee LY,Dong C,Lacorazza HD
11-5711 was used in Flow cytometry/Cell sorting to purified cells CD4+ T cells are inhibited from differentiating into Th17 cells by E74-like Factor 4.
Wed Jan 01 00:00:00 EST 2014
Rag2-deficient IL-1 Receptor Antagonist-deficient Mice Are a Novel Colitis Model in Which Innate Lymphoid Cell-derived IL-17 Is Involved in the Pathogenesis.
Experimental animals
Akitsu A,Kakuta S,Saijo S,Iwakura Y
11-5711 was used in Flow cytometry/Cell sorting to explore the relationship between IL-17A-producing cells and Treg cells in immune homeostasis of the colon.
Wed Oct 22 00:00:00 EDT 2014
Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema.
Science translational medicine
Shan M,Yuan X,Song LZ,Roberts L,Zarinkamar N,Seryshev A,Zhang Y,Hilsenbeck S,Chang SH,Dong C,Corry DB,Kheradmand F
11-5711 was used in Flow cytometry/Cell sorting to show that cigarette smoke increases the expression of IL-17A in both CD4+ and γδ T cells from mouse lung.
Wed Jan 18 00:00:00 EST 2012
Developmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medulla.
Journal of immunology (Baltimore, Md. : 1950)
Desanti GE,Cowan JE,Baik S,Parnell SM,White AJ,Penninger JM,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G
11-5711 was used in Flow cytometry/Cell sorting to study how multiple hemopoietic cell types regulate mTEC development through differential provision of RANKL/CD40L during ontogeny, revealing molecular differences in foetal and adult hemopoietic cross-talk.
Sat Dec 15 00:00:00 EST 2012
Blockade of IL-10 signaling during bacillus Calmette-Guérin vaccination enhances and sustains Th1, Th17, and innate lymphoid IFN-γ and IL-17 responses and increases protection to Mycobacterium tuberculosis infection.
Journal of immunology (Baltimore, Md. : 1950)
Pitt JM,Stavropoulos E,Redford PS,Beebe AM,Bancroft GJ,Young DB,O'Garra A
11-5711 was used in Flow cytometry/Cell sorting to demonstrate that antagonists of IL-10 may be of great benefit as adjuvants in preventive vaccination against tuberculosis.
Mon Oct 15 00:00:00 EDT 2012
Small intestinal intraepithelial lymphocytes expressing CD8 and T cell receptor γδ are involved in bacterial clearance during Salmonella enterica serovar Typhimurium infection.
Infection and immunity
Li Z,Zhang C,Zhou Z,Zhang J,Zhang J,Tian Z
11-5711 was used in Flow cytometry/Cell sorting to investigate the role of intestinal intraepithelial lymphocytes in responding to oral infection, showing that they express CD8 and T cell receptor γδ for bacterial clearance.
Wed Feb 01 00:00:00 EST 2012
Role of gamma-delta T cells in host response against Staphylococcus aureus-induced pneumonia.
BMC immunology
Cheng P,Liu T,Zhou WY,Zhuang Y,Peng LS,Zhang JY,Yin ZN,Mao XH,Guo G,Shi Y,Zou QM
11-5711 was used in Flow cytometry/Cell sorting to examine the kinetics of the γδ T cell response in the lungs of mice infected with S. aureus.
Mon Jul 09 00:00:00 EDT 2012
The innate immune response to uropathogenic Escherichia coli involves IL-17A in a murine model of urinary tract infection.
Journal of immunology (Baltimore, Md. : 1950)
Sivick KE,Schaller MA,Smith SN,Mobley HL
11-5711 was used in Flow cytometry/Cell sorting to show that IL-17A is a key mediator for the innate immune response to UTIs.
Mon Feb 15 00:00:00 EST 2010
Expression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine.
Gastroenterology
Shang L,Thirunarayanan N,Viejo-Borbolla A,Martin AP,Bogunovic M,Marchesi F,Unkeless JC,Ho Y,Furtado GC,Alcami A,Merad M,Mayer L,Lira SA
Published figure using TCR gamma/delta monoclonal antibody (Product # 11-5711-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2009
Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis.
International immunology
Siegemund S,Schütze N,Schulz S,Wolk K,Nasilowska K,Straubinger RK,Sabat R,Alber G
11-5711 was used in Flow cytometry/Cell sorting to study whether IL-22 and IL-17A production is initiated early in response to S. Enteritidis, showing that early production of IL-22 was dependent on IL-23, however IL-17A was only partially IL-23-dependent.
Fri May 01 00:00:00 EDT 2009
Nylon wool purification alters the activation of T cells.
Molecular immunology
Wohler JE,Barnum SR
11-5711 was used in Flow cytometry/Cell sorting to examine the effects of nylon wool purification on T cell proliferation, activation marker expression and cytokine production.
Sun Feb 01 00:00:00 EST 2009
