Product References
Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation.
Cell reports
Meyers AK,Wang Z,Han W,Zhao Q,Zabalawi M,Duan L,Liu J,Zhang Q,Manne RK,Lorenzo F,Quinn MA,Song Q,Fan D,Lin HK,Furdui CM,Locasale JW,McCall CE,Zhu X
12-1152-82 was used in Flow Cytometry to suggest a non-canonical role of mitochondrial PDHK in promoting mitochondrial stress and supporting NLRP3 inflammasome activation during acute inflammation.
Tue Jan 31 00:00:00 EST 2023
Platelets exacerbate cardiovascular inflammation in a murine model of Kawasaki disease vasculitis.
JCI insight
Kocatürk B,Lee Y,Nosaka N,Abe M,Martinon D,Lane ME,Moreira D,Chen S,Fishbein MC,Porritt RA,Franklin BS,Noval Rivas M,Arditi M
Published figure using CD115 (c-fms) monoclonal antibody (Product # 12-1152-82) in Flow Cytometry
Mon Jul 24 00:00:00 EDT 2023
Pexidartinib synergize PD-1 antibody through inhibiting treg infiltration by reducing TAM-derived CCL22 in lung adenocarcinoma.
Frontiers in pharmacology
Zhang W,Jiang X,Zou Y,Yuan L,Wang X
Published figure using CD115 (c-fms) monoclonal antibody (Product # 12-1152-82) in Flow Cytometry
Tue Mar 28 00:00:00 EDT 2023
MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα.
Signal transduction and targeted therapy
Feng L,Li C,Zeng LW,Gao D,Sun YH,Zhong L,Lin H,Shu HB,Li S
Published figure using CD115 (c-fms) monoclonal antibody (Product # 12-1152-82) in Flow Cytometry
Mon Jan 24 00:00:00 EST 2022
Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling.
The Journal of biological chemistry
Yan Q,Gao H,Yao Q,Ling K,Xiao G
Published figure using CD115 (c-fms) monoclonal antibody (Product # 12-1152-82) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2022
Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling.
The EMBO journal
Wieghofer P,Hagemeyer N,Sankowski R,Schlecht A,Staszewski O,Amann L,Gruber M,Koch J,Hausmann A,Zhang P,Boneva S,Masuda T,Hilgendorf I,Goldmann T,Böttcher C,Priller J,Rossi FM,Lange C,Prinz M
Published figure using CD115 (c-fms) monoclonal antibody (Product # 12-1152-82) in Flow Cytometry
Mon Mar 15 00:00:00 EDT 2021
Low-dose 2-deoxy glucose stabilises tolerogenic dendritic cells and generates potent in vivo immunosuppressive effects.
Cellular and molecular life sciences : CMLS
Christofi M,Le Sommer S,Mölzer C,Klaska IP,Kuffova L,Forrester JV
Published figure using CD115 (c-fms) monoclonal antibody (Product # 12-1152-82) in Flow Cytometry
Mon Mar 01 00:00:00 EST 2021
HOXA11 plays critical roles in disease progression and response to cytarabine in AML.
Oncology reports
Fu JF,Shih LY,Yen TH
Published figure using CD115 (c-fms) monoclonal antibody (Product # 12-1152-82) in Flow Cytometry
Thu Jul 01 00:00:00 EDT 2021
Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy.
Journal of neuroinflammation
Oladiran O,Shi XQ,Yang M,Fournier S,Zhang J
Published figure using CD115 (c-fms) monoclonal antibody (Product # 12-1152-82) in Flow Cytometry
Mon Mar 22 00:00:00 EDT 2021
CX3CR1 But Not CCR2 Expression Is Required for the Development of Autoimmune Peripheral Neuropathy in Mice.
Frontiers in immunology
Oladiran O,Shi XQ,Fournier S,Zhang J
Published figure using CD115 (c-fms) monoclonal antibody (Product # 12-1152-82) in Flow Cytometry
Tue Dec 21 00:00:00 EST 2021
Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics.
eLife
Serrano-Lopez J,Hegde S,Kumar S,Serrano J,Fang J,Wellendorf AM,Roche PA,Rangel Y,Carrington LJ,Geiger H,Grimes HL,Luther S,Maillard I,Sanchez-Garcia J,Starczynowski DT,Cancelas JA
Published figure using CD115 (c-fms) monoclonal antibody (Product # 12-1152-82) in Flow Cytometry
Thu Apr 08 00:00:00 EDT 2021
Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia.
Molecular metabolism
La Rose AM,Bazioti V,Hoogerland JA,Svendsen AF,Groenen AG,van Faassen M,Rutten MGS,Kloosterhuis NJ,Dethmers-Ausema B,Nijland JH,Mithieux G,Rajas F,Kuipers F,Lukens MV,Soehnlein O,Oosterveer MH,Westerterp M
Published figure using CD115 (c-fms) monoclonal antibody (Product # 12-1152-82) in Flow Cytometry
Mon Nov 01 00:00:00 EDT 2021
The AML-associated K313 mutation enhances C/EBPα activity by leading to C/EBPα overexpression.
Cell death & disease
Gentle IE,Moelter I,Badr MT,Döhner K,Lübbert M,Häcker G
12-1152-82 was used in Flow Cytometry to show that the K313 mutation caused strongly elevated expression of C/EBPα-protein, which could also be seen in primary K313 mutated AML blasts, explaining the enhanced C/EBPα activity in K313-expressing cells.
Mon Jul 05 00:00:00 EDT 2021
Sleep enhances numbers and function of monocytes and improves bacterial infection outcome in mice.
Brain, behavior, and immunity
Hahn J,Günter M,Schuhmacher J,Bieber K,Pöschel S,Schütz M,Engelhardt B,Oster H,Sina C,Lange T,Autenrieth SE
12-1152-82 was used in Flow Cytometry to elucidate whether sleep affects the numbers and functions of innate immune cells and their defense against systemic bacterial infection.
Wed Jul 01 00:00:00 EDT 2020
Enzalutamide, an Androgen Receptor Antagonist, Enhances Myeloid Cell-Mediated Immune Suppression and Tumor Progression.
Cancer immunology research
Consiglio CR,Udartseva O,Ramsey KD,Bush C,Gollnick SO
12-1152 was used in Flow cytometry/Cell sorting to investigate how AR antagonism affects myeloid cell function and metabolism in an AR-independent murine colon tumor model.
Tue Sep 01 00:00:00 EDT 2020
Radiation causes tissue damage by dysregulating inflammasome-gasdermin D signaling in both host and transplanted cells.
PLoS biology
Xiao J,Wang C,Yao JC,Alippe Y,Yang T,Kress D,Sun K,Kostecki KL,Monahan JB,Veis DJ,Abu-Amer Y,Link DC,Mbalaviele G
Published figure using CD115 (c-fms) monoclonal antibody (Product # 12-1152-82) in Flow Cytometry
Sat Aug 01 00:00:00 EDT 2020
Radiation causes tissue damage by dysregulating inflammasome-gasdermin D signaling in both host and transplanted cells.
PLoS biology
Xiao J,Wang C,Yao JC,Alippe Y,Yang T,Kress D,Sun K,Kostecki KL,Monahan JB,Veis DJ,Abu-Amer Y,Link DC,Mbalaviele G
Published figure using CD115 (c-fms) monoclonal antibody (Product # 12-1152-82) in Flow Cytometry
Sat Aug 01 00:00:00 EDT 2020
Temporospatial distribution and transcriptional profile of retinal microglia in the oxygen-induced retinopathy mouse model.
Glia
Boeck M,Thien A,Wolf J,Hagemeyer N,Laich Y,Yusuf D,Backofen R,Zhang P,Boneva S,Stahl A,Hilgendorf I,Agostini H,Prinz M,Wieghofer P,Schlunck G,Schlecht A,Lange C
Published figure using CD115 (c-fms) monoclonal antibody (Product # 12-1152-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2020
Dietary Choline Supplementation Attenuates High-Fat-Diet-Induced Hepatocellular Carcinoma in Mice.
The Journal of nutrition
Brown AL,Conrad K,Allende DS,Gromovsky AD,Zhang R,Neumann CK,Owens AP,Tranter M,Helsley RN
12-1152-82 was used in Flow Cytometry to study whether choline supplementation could influence the progression of hepatocellular carcinoma in a high-fat-diet-driven mouse model.
Wed Apr 01 00:00:00 EDT 2020
Androgen Receptor Signaling Positively Regulates Monocytic Development.
Frontiers in immunology
Consiglio CR,Gollnick SO
12-1152 was used in Flow cytometry/Cell sorting to investigate the role of androgen signaling in monocytic differentiation with a genetic mouse model of myeloid androgen receptor (AR) knockout (MARKO) and pharmacological inhibition of AR.
Thu Apr 29 00:00:00 EDT 2021
Androgen Receptor Signaling Positively Regulates Monocytic Development.
Frontiers in immunology
Consiglio CR,Gollnick SO
12-1152 was used in Flow cytometry/Cell sorting to investigate the role of androgen signaling in monocytic differentiation with a genetic mouse model of myeloid androgen receptor (AR) knockout (MARKO) and pharmacological inhibition of AR.
Thu Apr 29 00:00:00 EDT 2021
Establishment of bone marrow-derived M-CSF receptor-dependent self-renewing macrophages.
Cell death discovery
Nasser H,Adhikary P,Abdel-Daim A,Noyori O,Panaampon J,Kariya R,Okada S,Ma W,Baba M,Takizawa H,Yamane M,Niwa H,Suzu S
12-1152 was used in Flow cytometry/Cell sorting to show the presence of adult bone marrow-derived macrophages that retain self-renewing capacity.
Tue Sep 26 00:00:00 EDT 2023
N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease.
Nature communications
Lee JY,Han SH,Park MH,Song IS,Choi MK,Yu E,Park CM,Kim HJ,Kim SH,Schuchman EH,Jin HK,Bae JS
12-1152 was used in Flow cytometry/Cell sorting to identify a role of N-AS in the dysfunction of microglia in AD.
Tue May 12 00:00:00 EDT 2020
Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity.
Cell reports
Tur J,Pereira-Lopes S,Vico T,Marín EA,Muñoz JP,Hernández-Alvarez M,Cardona PJ,Zorzano A,Lloberas J,Celada A
12-1152 was used in Flow cytometry/Cell sorting to reveal an unexpected contribution of Mfn2 to ROS production and inflammation in macrophages.
Tue Aug 25 00:00:00 EDT 2020
Visualizing the functional 3D shape and topography of long noncoding RNAs by single-particle atomic force microscopy and in-solution hydrodynamic techniques.
Nature protocols
Uroda T,Chillón I,Annibale P,Teulon JM,Pessey O,Karuppasamy M,Pellequer JL,Marcia M
12-1152-82 was used in Flow Cytometry to present a protocol that integrates non-denaturing lncRNA purification with in-solution hydrodynamic analysis and single-particle atomic force microscopy (AFM) imaging to produce highly homogeneous lncRNA preparations and visualize their 3D topology at ~15-Å resolution.
Mon Jun 01 00:00:00 EDT 2020
The cis-Regulatory Atlas of the Mouse Immune System.
Cell
Yoshida H,Lareau CA,Ramirez RN,Rose SA,Maier B,Wroblewska A,Desland F,Chudnovskiy A,Mortha A,Dominguez C,Tellier J,Kim E,Dwyer D,Shinton S,Nabekura T,Qi Y,Yu B,Robinette M,Kim KW,Wagers A,Rhoads A,Nutt SL,Brown BD,Mostafavi S,Buenrostro JD,Benoist C
12-1152-82 was used in Flow Cytometry to generate matched epigenome and transcriptome measurements in 86 primary cell types that span the mouse immune system and its differentiation cascade.
Thu Feb 07 00:00:00 EST 2019
The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin.
Immunity
Burzynski LC,Humphry M,Pyrillou K,Wiggins KA,Chan JNE,Figg N,Kitt LL,Summers C,Tatham KC,Martin PB,Bennett MR,Clarke MCH
12-1152-82 was used in Flow Cytometry to show that thrombin-cleaved IL-1α was detected in humans during sepsis, pointing to the relevance of this pathway for normal physiology and the pathogenesis of inflammatory and thrombotic diseases.
Tue Apr 16 00:00:00 EDT 2019
Concomitant type I IFN and M-CSF signaling reprograms monocyte differentiation and drives pro-tumoral arginase production.
EBioMedicine
Tong Y,Zhou L,Yang L,Guo P,Cao Y,Qin FX,Liu J
Published figure using CD115 (c-fms) monoclonal antibody (Product # 12-1152-82) in Flow Cytometry
Tue Jan 01 00:00:00 EST 2019
Glucose lowering by SGLT2-inhibitor empagliflozin accelerates atherosclerosis regression in hyperglycemic STZ-diabetic mice.
Scientific reports
Pennig J,Scherrer P,Gissler MC,Anto-Michel N,Hoppe N,Füner L,Härdtner C,Stachon P,Wolf D,Hilgendorf I,Mullick A,Bode C,Zirlik A,Goldberg IJ,Willecke F
12-1152 was used in Flow cytometry/Cell sorting to determine whether glucose lowering by empagliflozin accelerates atherosclerosis regression in a mouse model.
Fri Nov 29 00:00:00 EST 2019
Non-classical monocytes as mediators of tissue destruction in arthritis.
Annals of the rheumatic diseases
Puchner A,Saferding V,Bonelli M,Mikami Y,Hofmann M,Brunner JS,Caldera M,Goncalves-Alves E,Binder NB,Fischer A,Simader E,Steiner CW,Leiss H,Hayer S,Niederreiter B,Karonitsch T,Koenders MI,Podesser BK,O'Shea JJ,Menche J,Smolen JS,Redlich K,Blüml S
12-1152 was used in Flow cytometry/Cell sorting to deduce that non-classical monocytes are pivotal cells in arthritis tissue damage.
Mon Oct 01 00:00:00 EDT 2018
p38α blocks brown adipose tissue thermogenesis through p38δ inhibition.
PLoS biology
Matesanz N,Nikolic I,Leiva M,Pulgarín-Alfaro M,Santamans AM,Bernardo E,Mora A,Herrera-Melle L,Rodríguez E,Beiroa D,Caballero A,Martín-García E,Acín-Pérez R,Hernández-Cosido L,Leiva-Vega L,Torres JL,Centeno F,Nebreda AR,Enríquez JA,Nogueiras R,Marcos M,Sabio G
12-1152 was used in Flow cytometry/Cell sorting to study the effects of a lack of p38α in protecting against high-fat diet-induced obesity.
Sun Jul 01 00:00:00 EDT 2018
Bone loss in C57BL/6J-OlaHsd mice, a substrain of C57BL/6J carrying mutated alpha-synuclein and multimerin-1 genes.
Journal of cellular physiology
Liron T,Raphael B,Hiram-Bab S,Bab IA,Gabet Y
Published figure using CD115 (c-fms) monoclonal antibody (Product # 12-1152-82) in Flow Cytometry
Mon Jan 01 00:00:00 EST 2018
Captopril mitigates splenomegaly and myelofibrosis in the Gata1low murine model of myelofibrosis.
Journal of cellular and molecular medicine
Corey SJ,Jha J,McCart EA,Rittase WB,George J,Mattapallil JJ,Mehta H,Ognoon M,Bylicky MA,Summers TA,Day RM
Published figure using CD115 (c-fms) monoclonal antibody (Product # 12-1152-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2018
Neutrophil and Macrophage Cell Surface Colony-Stimulating Factor 1 Shed by ADAM17 Drives Mouse Macrophage Proliferation in Acute and Chronic Inflammation.
Molecular and cellular biology
Tang J,Frey JM,Wilson CL,Moncada-Pazos A,Levet C,Freeman M,Rosenfeld ME,Stanley ER,Raines EW,Bornfeldt KE
12-1152 was used in Flow cytometry/Cell sorting to identify a significant defect in macrophage proliferation in mice lacking leukocyte transmembrane protease, ADAM17.
Sat Sep 01 00:00:00 EDT 2018
Advanced Glycation End Products Enhance Murine Monocyte Proliferation in Bone Marrow and Prime Them into an Inflammatory Phenotype through MAPK Signaling.
Journal of diabetes research
Jin X,Liu L,Zhang Y,Xiang Y,Yin G,Lu Y,Shi L,Dong J,Shen C
Published figure using CD115 (c-fms) monoclonal antibody (Product # 12-1152-82) in Flow Cytometry
Wed Oct 10 00:00:00 EDT 2018
Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells.
Cell reports
Kirkling ME,Cytlak U,Lau CM,Lewis KL,Resteu A,Khodadadi-Jamayran A,Siebel CW,Salmon H,Merad M,Tsirigos A,Collin M,Bigley V,Reizis B
Tue Jun 19 00:00:00 EDT 2018
Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen.
Immunity
Lim HY,Lim SY,Tan CK,Thiam CH,Goh CC,Carbajo D,Chew SHS,See P,Chakarov S,Wang XN,Lim LH,Johnson LA,Lum J,Fong CY,Bongso A,Biswas A,Goh C,Evrard M,Yeo KP,Basu R,Wang JK,Tan Y,Jain R,Tikoo S,Choong C,Weninger W,Poidinger M,Stanley RE,Collin M,Tan NS,Ng LG,Jackson DG,Ginhoux F,Angeli V
12-1152-82 was used in Flow cytometry/Cell sorting to unveil a hitherto unknown homeostatic contribution of arterial LYVE-1+ macrophages through the control of collagen production by SMCs and has identified a function of LYVE-1 in leukocytes.
Tue Aug 21 00:00:00 EDT 2018
Indoleamine 2 3-dioxygenase knockout limits angiotensin II-induced aneurysm in low density lipoprotein receptor-deficient mice fed with high fat diet.
PloS one
Metghalchi S,Vandestienne M,Haddad Y,Esposito B,Dairou J,Tedgui A,Mallat Z,Potteaux S,Taleb S
12-1152 was used in Flow cytometry/Cell sorting to show that the knockout of IDO prevented VSMC apoptosis in AngII -treated Ldlr-/- mice fed with HFD, suggesting a detrimental role of IDO in AAA formation and thus would be an important target for the treatment of aneurysm.
Fri Jun 22 00:00:00 EDT 2018
Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity.
Cell metabolism
Westerterp M,Gautier EL,Ganda A,Molusky MM,Wang W,Fotakis P,Wang N,Randolph GJ,D'Agati VD,Yvan-Charvet L,Tall AR
12-1152 was used in Flow cytometry/Cell sorting to identify an essential role of DC cholesterol efflux pathways in maintaining immune tolerance.
Tue Jun 06 00:00:00 EDT 2017
Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.
The Journal of experimental medicine
Thomas DC,Clare S,Sowerby JM,Pardo M,Juss JK,Goulding DA,van der Weyden L,Storisteanu D,Prakash A,Espéli M,Flint S,Lee JC,Hoenderdos K,Kane L,Harcourt K,Mukhopadhyay S,Umrania Y,Antrobus R,Nathan JA,Adams DJ,Bateman A,Choudhary JS,Lyons PA,Condliffe AM,Chilvers ER,Dougan G,Smith KG
12-1152 was used in Flow cytometry/Cell sorting to describe the key role of the previously uncharacterised protein Eros in host defence.
Mon Apr 03 00:00:00 EDT 2017
Dietary PUFAs attenuate NLRP3 inflammasome activation via enhancing macrophage autophagy.
Journal of lipid research
Shen L,Yang Y,Ou T,Key CC,Tong SH,Sequeira RC,Nelson JM,Nie Y,Wang Z,Boudyguina E,Shewale SV,Zhu X
Fri Sep 01 00:00:00 EDT 2017
Differential effect of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) on leukocyte infiltration during contact hypersensitivity responses.
PeerJ
Early M,Schroeder WG,Unnithan R,Gilchrist JM,Muller WA,Schenkel A
Mon Dec 14 00:00:00 EST 2020
Erythropoietin enhances Kupffer cell number and activity in the challenged liver.
Scientific reports
Gilboa D,Haim-Ohana Y,Deshet-Unger N,Ben-Califa N,Hiram-Bab S,Reuveni D,Zigmond E,Gassmann M,Gabet Y,Varol C,Neumann D
Published figure using CD115 (c-fms) monoclonal antibody (Product # 12-1152-82) in Flow Cytometry
Mon Sep 04 00:00:00 EDT 2017
The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation.
Nature communications
Ratsimandresy RA,Chu LH,Khare S,de Almeida L,Gangopadhyay A,Indramohan M,Misharin AV,Greaves DR,Perlman H,Dorfleutner A,Stehlik C
12-1152 was used in Flow cytometry/Cell sorting to investigate the complex interactions governing inflammasome assembly and function.
Mon Jun 05 00:00:00 EDT 2017
Human Neutrophil Peptide 1 Limits Hypercholesterolemia-induced Atherosclerosis by Increasing Hepatic LDL Clearance.
EBioMedicine
Paulin N,Döring Y,Kooijman S,Blanchet X,Viola JR,de Jong R,Mandl M,Hendrikse J,Schiener M,von Hundelshausen P,Vogt A,Weber C,Bdeir K,Hofmann SM,Rensen PCN,Drechsler M,Soehnlein O
12-1152 was used in Flow cytometry/Cell sorting to study the role of human neutrophil peptide 1 in a mouse model of atherosclerosis and identify its therapeutic potential.
Wed Feb 01 00:00:00 EST 2017
Neutrophil stunning by metoprolol reduces infarct size.
Nature communications
García-Prieto J,Villena-Gutiérrez R,Gómez M,Bernardo E,Pun-García A,García-Lunar I,Crainiciuc G,Fernández-Jiménez R,Sreeramkumar V,Bourio-Martínez R,García-Ruiz JM,Del Valle AS,Sanz-Rosa D,Pizarro G,Fernández-Ortiz A,Hidalgo A,Fuster V,Ibanez B
12-1152 was used in Flow cytometry/Cell sorting to demonstrate that metoprolol reduces reperfusion injury by targeting the haematopoietic compartment.
Tue Apr 18 00:00:00 EDT 2017
Control of metastatic niche formation by targeting APBA3/Mint3 in inflammatory monocytes.
Proceedings of the National Academy of Sciences of the United States of America
Hara T,Nakaoka HJ,Hayashi T,Mimura K,Hoshino D,Inoue M,Nagamura F,Murakami Y,Seiki M,Sakamoto T
12-1152-82 was used in Flow cytometry/Cell sorting to report that APBA3-deficient mice show reduced metastasis, with no apparent effect on primary tumor growth.
Tue May 30 00:00:00 EDT 2017
Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice.
Circulation research
Viola JR,Lemnitzer P,Jansen Y,Csaba G,Winter C,Neideck C,Silvestre-Roig C,Dittmar G,Döring Y,Drechsler M,Weber C,Zimmer R,Cenac N,Soehnlein O
12-1152 was used in Flow cytometry/Cell sorting to present evidence for the imbalance between inflammatory and resolving lipid mediators during atheroprogression, suggesting a novel strategy for resolving arterial inflammation.
Fri Oct 14 00:00:00 EDT 2016
PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.
The Journal of clinical investigation
Cole CB,Verdoni AM,Ketkar S,Leight ER,Russler-Germain DA,Lamprecht TL,Demeter RT,Magrini V,Ley TJ
12-1152 was used in Flow cytometry/Cell sorting to suggest that PML-RARA requires DNMT3A to initiate acute promyelocytic leukemia in mice.
Fri Jan 01 00:00:00 EST 2016
Monocyte Adhesion and Plaque Recruitment During Atherosclerosis Development Is Regulated by the Adapter Protein Chat-H/SHEP1.
Arteriosclerosis, thrombosis, and vascular biology
Herbin O,Regelmann AG,Ramkhelawon B,Weinstein EG,Moore KJ,Alexandropoulos K
12-1152 was used in Flow cytometry/Cell sorting to analyse the role of Chat-H in atherosclerosis development, showing that monocyte adhesion and plaque recruitment is regulated by Chat-H/SHEP1.
Thu Sep 01 00:00:00 EDT 2016
Neuropeptide Y Induces Hematopoietic Stem/Progenitor Cell Mobilization by Regulating Matrix Metalloproteinase-9 Activity Through Y1 Receptor in Osteoblasts.
Stem cells (Dayton, Ohio)
Park MH,Lee JK,Kim N,Min WK,Lee JE,Kim KT,Akiyama H,Herzog H,Schuchman EH,Jin HK,Bae JS
Mon Aug 01 00:00:00 EDT 2016
Enforced Expression of Hoxa3 Inhibits Classical and Promotes Alternative Activation of Macrophages In Vitro and In Vivo.
Journal of immunology (Baltimore, Md. : 1950)
Al Sadoun H,Burgess M,Hentges KE,Mace KA
Published figure using CD115 (c-fms) monoclonal antibody (Product # 12-1152-82) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2016
PER1 prevents excessive innate immune response during endotoxin-induced liver injury through regulation of macrophage recruitment in mice.
Cell death & disease
Wang T,Wang Z,Yang P,Xia L,Zhou M,Wang S,Du J,Zhang J
Published figure using CD115 (c-fms) monoclonal antibody (Product # 12-1152-82) in Flow Cytometry
Thu Apr 07 00:00:00 EDT 2016
Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair.
eLife
Barreiro O,Cibrian D,Clemente C,Alvarez D,Moreno V,Valiente Í,Bernad A,Vestweber D,Arroyo AG,Martín P,von Andrian UH,Sánchez Madrid F
12-1152 was used in Flow cytometry/Cell sorting to describe a novel subset of murine dermal perivascular macrophages that extend protrusions across the endothelial junctions in steady-state and capture blood-borne macromolecules.
Wed Jun 15 00:00:00 EDT 2016
Disruption of c-Kit Signaling in Kit(W-sh/W-sh) Growing Mice Increases Bone Turnover.
Scientific reports
Lotinun S,Krishnamra N
12-1152 was used in Flow cytometry/Cell sorting to investigate the role of c-kit signalling in C57BL/6J-Kit(W-sh)/(W-sh) mice, showing that the disruption of c-kit signalling increases bone turnover.
Tue Aug 16 00:00:00 EDT 2016
Endothelial Cell-Selective Adhesion Molecule Expression in Hematopoietic Stem/Progenitor Cells Is Essential for Erythropoiesis Recovery after Bone Marrow Injury.
PloS one
Sudo T,Yokota T,Okuzaki D,Ueda T,Ichii M,Ishibashi T,Isono T,Habuchi Y,Oritani K,Kanakura Y
12-1152 was used in Flow cytometry/Cell sorting to determine the physiological importance of Endothelial Cell-Selective Adhesion Molecule (ESAM) in erythroid recovery, showing that ESAM is essential for erthryopoiesis recovery following bone marrow injury.
Tue Mar 14 00:00:00 EDT 2017
Reprogramming of Normal Fibroblasts into Cancer-Associated Fibroblasts by miRNAs-Mediated CCL2/VEGFA Signaling.
PLoS genetics
Shen H,Yu X,Yang F,Zhang Z,Shen J,Sun J,Choksi S,Jitkaew S,Shu Y
12-1152 was used in Flow cytometry/Cell sorting to investigate the mechanism of how cancer cells transform normal fibroblasts into cancer-associated fibroblasts.
Mon Aug 01 00:00:00 EDT 2016
Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer.
Nature communications
Dubeykovskaya Z,Si Y,Chen X,Worthley DL,Renz BW,Urbanska AM,Hayakawa Y,Xu T,Westphalen CB,Dubeykovskiy A,Chen D,Friedman RA,Asfaha S,Nagar K,Tailor Y,Muthupalani S,Fox JG,Kitajewski J,Wang TC
12-1152 was used in Flow cytometry/Cell sorting to show that TFF2 is released by vagally modulated memory T cells to suppress the expansion of myeloid-derived suppressor cells through CXCR4.
Thu Feb 04 00:00:00 EST 2016
Functional TRAIL receptors in monocytes and tumor-associated macrophages: A possible targeting pathway in the tumor microenvironment.
Oncotarget
Liguori M,Buracchi C,Pasqualini F,Bergomas F,Pesce S,Sironi M,Grizzi F,Mantovani A,Belgiovine C,Allavena P
12-1152 was used in Flow cytometry/Cell sorting to demonstrate that human and murine monocytes/macrophages are, among leukocytes, uniquely susceptible to TRAIL-mediated killing.
Tue Jul 05 00:00:00 EDT 2016
Timing of CSF-1/CSF-1R signaling blockade is critical to improving responses to CTLA-4 based immunotherapy.
Oncoimmunology
Holmgaard RB,Brachfeld A,Gasmi B,Jones DR,Mattar M,Doman T,Murphy M,Schaer D,Wolchok JD,Merghoub T
12-1152 was used in Flow cytometry/Cell sorting to show that both CSF-1 and its receptor (CSF-1R) are frequently expressed in tumors from cancer patients, and that this expression correlates with tumor-infiltration of MDSCs.
Fri Jul 01 00:00:00 EDT 2016
Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability.
Cell metabolism
Lodhi IJ,Wei X,Yin L,Feng C,Adak S,Abou-Ezzi G,Hsu FF,Link DC,Semenkovich CF
12-1152 was used in Flow cytometry/Cell sorting to investigate the immunometabolism pathway by which peroxisomal lipid synthesis regulates neutrophil development and inflammation.
Tue Jan 06 00:00:00 EST 2015
Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor.
Nature immunology
Grajales-Reyes GE,Iwata A,Albring J,Wu X,Tussiwand R,Kc W,Kretzer NM,Briseño CG,Durai V,Bagadia P,Haldar M,Schönheit J,Rosenbauer F,Murphy TL,Murphy KM
12-1152 was used in Flow cytometry/Cell sorting to investigate the role of the transcription factors Batf3 and IRF8 in the development of CD8α(+) conventional dendritic cells (cDCs)..
Wed Jul 01 00:00:00 EDT 2015
Host microbiota constantly control maturation and function of microglia in the CNS.
Nature neuroscience
Erny D,Hrabě de Angelis AL,Jaitin D,Wieghofer P,Staszewski O,David E,Keren-Shaul H,Mahlakoiv T,Jakobshagen K,Buch T,Schwierzeck V,Utermöhlen O,Chun E,Garrett WS,McCoy KD,Diefenbach A,Staeheli P,Stecher B,Amit I,Prinz M
12-1152 was used in Flow cytometry/Cell sorting to suggest that host bacteria vitally regulate microglia maturation and function in the central nervous system.
Wed Jul 01 00:00:00 EDT 2015
Phospholipid oxidation generates potent anti-inflammatory lipid mediators that mimic structurally related pro-resolving eicosanoids by activating Nrf2.
EMBO molecular medicine
Bretscher P,Egger J,Shamshiev A,Trötzmüller M,Köfeler H,Carreira EM,Kopf M,Freigang S
12-1152 was used in Flow cytometry/Cell sorting to provide a molecular basis for the negative regulation of inflammation by lipid peroxidation products and propose a novel class of highly bioactive compounds for the treatment of inflammatory diseases.
Fri May 01 00:00:00 EDT 2015
Neuropeptide Y regulates the hematopoietic stem cell microenvironment and prevents nerve injury in the bone marrow.
The EMBO journal
Park MH,Jin HK,Min WK,Lee WW,Lee JE,Akiyama H,Herzog H,Enikolopov GN,Schuchman EH,Bae JS
12-1152 was used in Flow cytometry/Cell sorting to examine the role of neuropeptide Y in the sympathetic nervous system control over the bone marrow environment.
Fri Jun 12 00:00:00 EDT 2015
Role of Inflammatory Monocytes in Vaccine-Induced Reduction of Helicobacter felis Infection.
Infection and immunity
Moyat M,Mack M,Bouzourene H,Velin D
12-1152 was used in Flow cytometry/Cell sorting to show that inflammatory monocytes play a direct role in immunization-induced reduction of Helicobacter felis infection from the gastric mucosa.
Sun Nov 01 00:00:00 EDT 2015
Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion.
Nature medicine
Bruns I,Lucas D,Pinho S,Ahmed J,Lambert MP,Kunisaki Y,Scheiermann C,Schiff L,Poncz M,Bergman A,Frenette PS
12-1152 was used in Flow cytometry/Cell sorting to indicate that a terminally differentiated cell type derived from HSCs contributes to the HSC niche, directly regulating HSC behavior.
Sat Nov 01 00:00:00 EDT 2014
Activation of CXCR7 limits atherosclerosis and improves hyperlipidemia by increasing cholesterol uptake in adipose tissue.
Circulation
Li X,Zhu M,Penfold ME,Koenen RR,Thiemann A,Heyll K,Akhtar S,Koyadan S,Wu Z,Gremse F,Kiessling F,van Zandvoort M,Schall TJ,Weber C,Schober A
12-1152 was used in Flow cytometry/Cell sorting to determine the role of the chemokine receptor, CXCR7, in atherosclerosis and vascular remodelling.
Tue Mar 18 00:00:00 EDT 2014
Myeloid cell-specific ATP-binding cassette transporter A1 deletion has minimal impact on atherogenesis in atherogenic diet-fed low-density lipoprotein receptor knockout mice.
Arteriosclerosis, thrombosis, and vascular biology
Bi X,Zhu X,Gao C,Shewale S,Cao Q,Liu M,Boudyguina E,Gebre AK,Wilson MD,Brown AL,Parks JS
12-1152 was used in Flow cytometry/Cell sorting to assess the atherosclerotic impact of myeloid cell ATP-binding cassette transporter A1.
Mon Sep 01 00:00:00 EDT 2014
Blocking junctional adhesion molecule C enhances dendritic cell migration and boosts the immune responses against Leishmania major.
PLoS pathogens
Ballet R,Emre Y,Jemelin S,Charmoy M,Tacchini-Cottier F,Imhof BA
12-1152 was used in Flow cytometry/Cell sorting to illustrate a key role for the vascular adhesion molecule JAM-C in controlling leukocyte migration and subsequent immune events in response to pathogen infections.
Mon Dec 01 00:00:00 EST 2014
Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness.
Laboratory investigation; a journal of technical methods and pathology
Wang Y,Jin TH,Farhana A,Freeman J,Estell K,Zmijewski JW,Gaggar A,Thannickal VJ,Schwiebert LM,Steyn AJ,Deshane JS
12-1152 was used in Flow cytometry/Cell sorting to assess the effects of exposing myeloid-derived regulatory cells to cigarette smoke on the production of nitric oxide.
Mon Dec 01 00:00:00 EST 2014
Macrophage depletion abates Porphyromonas gingivalis-induced alveolar bone resorption in mice.
Journal of immunology (Baltimore, Md. : 1950)
Lam RS,O'Brien-Simpson NM,Lenzo JC,Holden JA,Brammar GC,Walsh KA,McNaughtan JE,Rowler DK,Van Rooijen N,Reynolds EC
12-1152 was used in Flow cytometry/Cell sorting to define the role of the macrophage in the immunopathology of periodontitis.
Mon Sep 01 00:00:00 EDT 2014
Pneumolysin expression by streptococcus pneumoniae protects colonized mice from influenza virus-induced disease.
Virology
Wolf AI,Strauman MC,Mozdzanowska K,Williams KL,Osborne LC,Shen H,Liu Q,Garlick D,Artis D,Hensley SE,Caton AJ,Weiser JN,Erikson J
12-1152-82 was used in Flow Cytometry to investigate severity of influenza virus response with respiratory microbe presence.
Fri Aug 01 00:00:00 EDT 2014
Macropinocytosis and TAK1 mediate anti-inflammatory to pro-inflammatory macrophage differentiation by HIV-1 Nef.
Cell death & disease
Hashimoto M,Nasser H,Chihara T,Suzu S
12-1152 was used in Flow cytometry/Cell sorting to determine the mechanism of pro-inflammatory macrophage transition by HIV-1 pathogenetic protein Nef.
Thu May 29 00:00:00 EDT 2014
Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration.
Nature medicine
Lucas D,Scheiermann C,Chow A,Kunisaki Y,Bruns I,Barrick C,Tessarollo L,Frenette PS
12-1152 was used in Flow cytometry/Cell sorting to demonstrate the potential benefit of adrenergic nerve protection for shielding hematopoietic niches from injury.
Sat Jun 01 00:00:00 EDT 2013
Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration.
Nature medicine
Lucas D,Scheiermann C,Chow A,Kunisaki Y,Bruns I,Barrick C,Tessarollo L,Frenette PS
12-1152 was used in Flow cytometry/Cell sorting to demonstrate the potential benefit of adrenergic nerve protection for shielding hematopoietic niches from injury.
Sat Jun 01 00:00:00 EDT 2013
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.
Nature cell biology
Zhang Y,Yang P,Sun T,Li D,Xu X,Rui Y,Li C,Chong M,Ibrahim T,Mercatali L,Amadori D,Lu X,Xie D,Li QJ,Wang XF
Published figure using CD115 (c-fms) monoclonal antibody (Product # 12-1152-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
Transepithelial migration of neutrophils into the lung requires TREM-1.
The Journal of clinical investigation
Klesney-Tait J,Keck K,Li X,Gilfillan S,Otero K,Baruah S,Meyerholz DK,Varga SM,Knudson CJ,Moninger TO,Moreland J,Zabner J,Colonna M
12-1152 was used in Flow cytometry/Cell sorting to demonstrate TREM-1's role in neutrophil migration across airway epithelial cells and that it amplifies inflammation via neutrophil migration into the lung.
Tue Jan 01 00:00:00 EST 2013
Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow.
The Journal of experimental medicine
Devi S,Wang Y,Chew WK,Lima R,A-González N,Mattar CN,Chong SZ,Schlitzer A,Bakocevic N,Chew S,Keeble JL,Goh CC,Li JL,Evrard M,Malleret B,Larbi A,Renia L,Haniffa M,Tan SM,Chan JK,Balabanian K,Nagasawa T,Bachelerie F,Hidalgo A,Ginhoux F,Kubes P,Ng LG
12-1152 was used in Flow cytometry/Cell sorting to examine bone marrow neutrophil activity in response to G-CSF or CXCR4 inhibition by plerixafor treatments in vivo.
Mon Oct 21 00:00:00 EDT 2013
Regulation of adaptive immunity by the fractalkine receptor during autoimmune inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Garcia JA,Pino PA,Mizutani M,Cardona SM,Charo IF,Ransohoff RM,Forsthuber TG,Cardona AE
12-1152 was used in Flow cytometry/Cell sorting to determine the role of CX3CR1 in the trafficking and function of myeloid cells during experimental autoimmune encephalomyelitis.
Thu Aug 01 00:00:00 EDT 2013
High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery.
PLoS neglected tropical diseases
Aulner N,Danckaert A,Rouault-Hardoin E,Desrivot J,Helynck O,Commere PH,Munier-Lehmann H,Späth GF,Shorte SL,Milon G,Prina E
12-1152 was used in Flow cytometry/Cell sorting to develop a novel phenotypic screening assay using virulent Leishmania amastigotes growing inside primary macrophage to identify new chemical entities with bona fide drug potential.
Thu Nov 14 00:00:00 EST 2013
Mouse models and techniques for the isolation of the diabetic endothelium.
ISRN endocrinology
Darrow AL,Maresh JG,Shohet RV
12-1152 was used in Flow cytometry/Cell sorting to validate mouse models and endothelial isolation techniques for assessing diabetic endothelial dysfunction and vascular responses in vivo.
Wed Jul 10 00:00:00 EDT 2013
Activation of CD4+ T lymphocytes improves wound healing and survival after experimental myocardial infarction in mice.
Circulation
Hofmann U,Beyersdorf N,Weirather J,Podolskaya A,Bauersachs J,Ertl G,Kerkau T,Frantz S
12-1152 was used in Flow cytometry/Cell sorting to investigate the role of CD4+ T lymphocytes in wound healing after experimental myocardial infarction in mice.
Tue Apr 03 00:00:00 EDT 2012
Control of murine Ly6C(high) monocyte traffic and immunosuppressive activities by atypical chemokine receptor D6.
Blood
Savino B,Castor MG,Caronni N,Sarukhan A,Anselmo A,Buracchi C,Benvenuti F,Pinho V,Teixeira MM,Mantovani A,Locati M,Bonecchi R
12-1152 was used in Flow cytometry/Cell sorting to study how control of CCR2 ligands by D6 regulates the traffic of Ly6C(high) monocytes and controls their immunosuppressive potential.
Thu May 31 00:00:00 EDT 2012
Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo.
The Journal of experimental medicine
von Brühl ML,Stark K,Steinhart A,Chandraratne S,Konrad I,Lorenz M,Khandoga A,Tirniceriu A,Coletti R,Köllnberger M,Byrne RA,Laitinen I,Walch A,Brill A,Pfeiler S,Manukyan D,Braun S,Lange P,Riegger J,Ware J,Eckart A,Haidari S,Rudelius M,Schulz C,Echtler K,Brinkmann V,Schwaiger M,Preissner KT,Wagner DD,Mackman N,Engelmann B,Massberg S
12-1152 was used in Flow cytometry/Cell sorting to investigate a novel mouse model of deep vein thrombosis as a useful tool to study the sequence of disease events.
Mon Apr 09 00:00:00 EDT 2012
Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice.
PLoS pathogens
Cho JS,Guo Y,Ramos RI,Hebroni F,Plaisier SB,Xuan C,Granick JL,Matsushima H,Takashima A,Iwakura Y,Cheung AL,Cheng G,Lee DJ,Simon SI,Miller LS
12-1152 was used in Flow cytometry/Cell sorting to show that IL-1β and neutrophil abscess formation during an infection are functionally, temporally and spatially linked by neutrophil IL-1β production.
Fri Apr 19 00:00:00 EDT 2013
Control of macrophage lineage populations by CSF-1 receptor and GM-CSF in homeostasis and inflammation.
Immunology and cell biology
Lenzo JC,Turner AL,Cook AD,Vlahos R,Anderson GP,Reynolds EC,Hamilton JA
12-1152 was used in Flow cytometry/Cell sorting to determine how the hemopoietic growth factors, M-CSF or CSF-1, regulate their in vivo development and function.
Sun Apr 01 00:00:00 EDT 2012
Semaphorin 4A exerts a proangiogenic effect by enhancing vascular endothelial growth factor-A expression in macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Meda C,Molla F,De Pizzol M,Regano D,Maione F,Capano S,Locati M,Mantovani A,Latini R,Bussolino F,Giraudo E
12-1152 was used in Flow cytometry/Cell sorting to demonstrate that Sema4A activates a specialized and restricted genetic program in macrophages able to sustain angiogenesis.
Sun Apr 15 00:00:00 EDT 2012
In vivo inhibition of c-MYC in myeloid cells impairs tumor-associated macrophage maturation and pro-tumoral activities.
PloS one
Pello OM,Chèvre R,Laoui D,De Juan A,Lolo F,Andrés-Manzano MJ,Serrano M,Van Ginderachter JA,Andrés V
Published figure using CD115 (c-fms) monoclonal antibody (Product # 12-1152-82) in Flow Cytometry
Mon Feb 25 00:00:00 EST 2013
Quantitative analysis of monocyte subpopulations in murine atherosclerotic plaques by multiphoton microscopy.
PloS one
Haka AS,Potteaux S,Fraser H,Randolph GJ,Maxfield FR
12-1152 was used in Flow cytometry/Cell sorting to demonstrate that multiphoton microscopy can be used to monitor monocyte subpopulation trafficking in atherosclerotic plaques in living animals.
Fri Feb 15 00:00:00 EST 2013
IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ.
Nature immunology
Hsu LC,Enzler T,Seita J,Timmer AM,Lee CY,Lai TY,Yu GY,Lai LC,Temkin V,Sinzig U,Aung T,Nizet V,Weissman IL,Karin M
12-1152 was used in Flow cytometry/Cell sorting to observe neutrophilia in mice with an inducible deletion of IKKβ (Ikkβ(δ) mice) which is believed to be critical for innate immunity.
Tue Feb 01 00:00:00 EST 2011
Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.
Blood
Welch JS,Klco JM,Varghese N,Nagarajan R,Ley TJ
12-1152 was used in Flow cytometry/Cell sorting to test the prediction that RARA (retinoic acid receptor alpha) haploinsufficiency would contribute to acute promyelocytic leukemia (APL) pathogenesis.
Thu Feb 24 00:00:00 EST 2011
Monocytes control natural killer cell differentiation to effector phenotypes.
Blood
Soderquest K,Powell N,Luci C,van Rooijen N,Hidalgo A,Geissmann F,Walzer T,Lord GM,Martín-Fontecha A
12-1152 was used in Flow cytometry/Cell sorting to investigate whether NK-cell subsets have specific roles during antitumour responses and what signals drive their terminal maturation.
Thu Apr 28 00:00:00 EDT 2011
PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice.
The Journal of clinical investigation
Welch JS,Yuan W,Ley TJ
12-1152 was used in Flow cytometry/Cell sorting to study a platform for more accurately dissecting the early events in acute promyelocytic leukemia pathogenesis.
Fri Apr 01 00:00:00 EDT 2011
Regulation of human neutrophil Fcγ receptor IIa by C5a receptor promotes inflammatory arthritis in mice.
Arthritis and rheumatism
Tsuboi N,Ernandez T,Li X,Nishi H,Cullere X,Mekala D,Hazen M,Köhl J,Lee DM,Mayadas TN
12-1152 was used in Flow cytometry/Cell sorting to demonstrate the role of cross-talk between neutrophil C5aR and FcγRIIA in inflammatory arthritis.
Tue Feb 01 00:00:00 EST 2011
Excess circulating alternatively activated myeloid (M2) cells accelerate ALS progression while inhibiting experimental autoimmune encephalomyelitis.
PloS one
Vaknin I,Kunis G,Miller O,Butovsky O,Bukshpan S,Beers DR,Henkel JS,Yoles E,Appel SH,Schwartz M
12-1152 was used in Flow cytometry/Cell sorting to establish circulating MDSCs as a novel target for therapeutic intervention in ALS, at least at the early stage.
Mon Mar 26 00:00:00 EDT 2012
Resident intimal dendritic cells accumulate lipid and contribute to the initiation of atherosclerosis.
Circulation research
Paulson KE,Zhu SN,Chen M,Nurmohamed S,Jongstra-Bilen J,Cybulsky MI
12-1152 was used in Flow cytometry/Cell sorting to determine the role of resident intimal dendritic cells in the initiation of atheroscleros in mice.
Fri Feb 05 00:00:00 EST 2010
Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment.
Proceedings of the National Academy of Sciences of the United States of America
Ahn GO,Tseng D,Liao CH,Dorie MJ,Czechowicz A,Brown JM
12-1152 was used in Immunohistochemistry-immunofluorescence to examine whether neutralising CD11b monoclonal antibodies could inhibit the recruitment of myeloid cells into irradiated tumours and inhibit their regrowth.
Tue May 04 00:00:00 EDT 2010
Antigen-specific immunity and cross-priming by epithelial ovarian carcinoma-induced CD11b(+)Gr-1(+) cells.
Journal of immunology (Baltimore, Md. : 1950)
Tomihara K,Guo M,Shin T,Sun X,Ludwig SM,Brumlik MJ,Zhang B,Curiel TJ,Shin T
12-1152 was used in Flow cytometry/Cell sorting to investigate CD11b(+)Gr-1(+) cells found in epithelial ovarian cancer-bearing mice, which are induced by ovarian cancer cells and undergo antigen-specific immunity and cross-priming.
Tue Jun 01 00:00:00 EDT 2010
Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network.
The Journal of experimental medicine
Chorro L,Sarde A,Li M,Woollard KJ,Chambon P,Malissen B,Kissenpfennig A,Barbaroux JB,Groves R,Geissmann F
12-1152 was used in Flow cytometry/Cell sorting to investigate the mechanisms involved in Langerhans cell development and homeostasis.
Mon Dec 21 00:00:00 EST 2009
CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation.
The Journal of experimental medicine
Auffray C,Fogg DK,Narni-Mancinelli E,Senechal B,Trouillet C,Saederup N,Leemput J,Bigot K,Campisi L,Abitbol M,Molina T,Charo I,Hume DA,Cumano A,Lauvau G,Geissmann F
12-1152 was used in Flow cytometry/Cell sorting to show that macrophage/DC precursors give rise to conventional DCs,.
Mon Mar 16 00:00:00 EDT 2009
The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies.
Cancer research
Ozao-Choy J,Ma G,Kao J,Wang GX,Meseck M,Sung M,Schwartz M,Divino CM,Pan PY,Chen SH
12-1152 was used in Flow cytometry/Cell sorting to suggest that sunitinib can be used to reverse immune suppression and as a potentially useful adjunct for enhancing the efficacy of immune-based cancer therapy for advanced malignancies.
Sun Mar 15 00:00:00 EDT 2009
Role of MKP-1 in osteoclasts and bone homeostasis.
The American journal of pathology
Carlson J,Cui W,Zhang Q,Xu X,Mercan F,Bennett AM,Vignery A
12-1152 was used in Flow cytometry/Cell sorting to show that MKP-1 plays a role in the maintenance of bone mass and does so by negatively regulating MAPK-dependent osteoclast signaling.
Thu Oct 01 00:00:00 EDT 2009
An innate response to allogeneic nonself mediated by monocytes.
Journal of immunology (Baltimore, Md. : 1950)
Zecher D,van Rooijen N,Rothstein DM,Shlomchik WD,Lakkis FG
12-1152 was used in Flow cytometry/Cell sorting to investigate how innate immune system distinguishes self-tissues from those of other members of the same species.
Tue Dec 15 00:00:00 EST 2009
Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity.
Blood
Movahedi K,Guilliams M,Van den Bossche J,Van den Bergh R,Gysemans C,Beschin A,De Baetselier P,Van Ginderachter JA
12-1152 was used in Flow cytometry/Cell sorting to identify 2 distinct MDSC subfractions with clear morphologic, molecular, and functional differences.
Tue Apr 15 00:00:00 EDT 2008
Neutrophil-selective CD18 silencing using RNA interference in vivo.
Blood
Cullere X,Lauterbach M,Tsuboi N,Mayadas TN
12-1152 was used in Flow cytometry/Cell sorting to analyse leukocyte populations from transgenic mice with CD18-deficient neutrophils, generated using an miRNA approach.
Tue Apr 01 00:00:00 EDT 2008
G-CSF induction early in uropathogenic Escherichia coli infection of the urinary tract modulates host immunity.
Cellular microbiology
Ingersoll MA,Kline KA,Nielsen HV,Hultgren SJ
12-1152 was used in Flow cytometry/Cell sorting to investigate the mechanism of recruitment of neutrophils to the bladder during urinary tract infection, showing that G-CSF induction early in infection modulates host immunity.
Mon Dec 01 00:00:00 EST 2008
Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis.
The Journal of biological chemistry
Chen Y,Wang X,Di L,Fu G,Chen Y,Bai L,Liu J,Feng X,McDonald JM,Michalek S,He Y,Yu M,Fu YX,Wen R,Wu H,Wang D
Fri Oct 24 00:00:00 EDT 2008
Murine CXCL14 is dispensable for dendritic cell function and localization within peripheral tissues.
Molecular and cellular biology
Meuter S,Schaerli P,Roos RS,Brandau O,Bösl MR,von Andrian UH,Moser B
12-1152 was used in Flow cytometry/Cell sorting to investigate the process of dendritic cell recruitment to peripheral tissues, showing that murine CXCL14 is dispensable for dendritic cell function and localisation.
Thu Feb 01 00:00:00 EST 2007
