Product References
Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation.
Cell reports
Meyers AK,Wang Z,Han W,Zhao Q,Zabalawi M,Duan L,Liu J,Zhang Q,Manne RK,Lorenzo F,Quinn MA,Song Q,Fan D,Lin HK,Furdui CM,Locasale JW,McCall CE,Zhu X
Published figure using CD115 (c-fms) monoclonal antibody (Product # 25-1152-82) in Flow Cytometry
Tue Jan 31 00:00:00 EST 2023
Platelets exacerbate cardiovascular inflammation in a murine model of Kawasaki disease vasculitis.
JCI insight
Kocatürk B,Lee Y,Nosaka N,Abe M,Martinon D,Lane ME,Moreira D,Chen S,Fishbein MC,Porritt RA,Franklin BS,Noval Rivas M,Arditi M
Published figure using CD115 (c-fms) monoclonal antibody (Product # 25-1152-82) in Flow Cytometry
Mon Jul 24 00:00:00 EDT 2023
Pexidartinib synergize PD-1 antibody through inhibiting treg infiltration by reducing TAM-derived CCL22 in lung adenocarcinoma.
Frontiers in pharmacology
Zhang W,Jiang X,Zou Y,Yuan L,Wang X
25-1152-82 was used in Flow Cytometry to show that the combination of pexidartinib and PD-1 antibody showed a synergy and significantly improved the anti-tumor efficacy, through pexidartinib increasing CD8T/Treg ratio by reducing TAM-derived CCL22.
Tue Mar 28 00:00:00 EDT 2023
Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease.
Nature neuroscience
Schäffner E,Bosch-Queralt M,Edgar JM,Lehning M,Strauß J,Fleischer N,Kungl T,Wieghofer P,Berghoff SA,Reinert T,Krueger M,Morawski M,Möbius W,Barrantes-Freer A,Stieler J,Sun T,Saher G,Schwab MH,Wrede C,Frosch M,Prinz M,Reich DS,Flügel A,Stadelmann C,Fledrich R,Nave KA,Stassart RM
25-1152-82 was used in Flow cytometry/Cell sorting to demonstrate that myelin ensheathment itself becomes detrimental for axonal survival and increases the risk of axons degenerating in an autoimmune environment.
Sat Jul 01 00:00:00 EDT 2023
MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα.
Signal transduction and targeted therapy
Feng L,Li C,Zeng LW,Gao D,Sun YH,Zhong L,Lin H,Shu HB,Li S
Published figure using CD115 (c-fms) monoclonal antibody (Product # 25-1152-82) in Flow Cytometry
Mon Jan 24 00:00:00 EST 2022
Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling.
The Journal of biological chemistry
Yan Q,Gao H,Yao Q,Ling K,Xiao G
Published figure using CD115 (c-fms) monoclonal antibody (Product # 25-1152-82) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2022
Dynamic intron retention modulates gene expression in the monocytic differentiation pathway.
Immunology
Song R,Tikoo S,Jain R,Pinello N,Au AYM,Nagarajah R,Porse B,Rasko JEJ,J-L Wong J
25-1152-82 was used in Flow cytometry/Cell sorting to highlight the unique role of intron retention in the regulation of the monocytic differentiation pathway.
Tue Feb 01 00:00:00 EST 2022
Transcriptional and Distributional Profiling of Microglia in Retinal Angiomatous Proliferation.
International journal of molecular sciences
Schlecht A,Wolf J,Boneva S,Prinz G,Braunger BM,Wieghofer P,Agostini H,Schlunck G,Lange C
25-1152-82 was used in Flow cytometry/Cell sorting to find that MG are the dominant myeloid cell population at RAP sites, significantly altering their transcriptional profile during RAP formation, however, without showing substantial upregulation of angiomodulatory factors.
Tue Mar 22 00:00:00 EDT 2022
Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling.
The EMBO journal
Wieghofer P,Hagemeyer N,Sankowski R,Schlecht A,Staszewski O,Amann L,Gruber M,Koch J,Hausmann A,Zhang P,Boneva S,Masuda T,Hilgendorf I,Goldmann T,Böttcher C,Priller J,Rossi FM,Lange C,Prinz M
25-1152-82 was used in Flow Cytometry to examine myeloid subsets in distinct parts of the eye during homeostasis.
Mon Mar 15 00:00:00 EDT 2021
Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling.
The EMBO journal
Wieghofer P,Hagemeyer N,Sankowski R,Schlecht A,Staszewski O,Amann L,Gruber M,Koch J,Hausmann A,Zhang P,Boneva S,Masuda T,Hilgendorf I,Goldmann T,Böttcher C,Priller J,Rossi FM,Lange C,Prinz M
25-1152-82 was used in Flow Cytometry to examine myeloid subsets in distinct parts of the eye during homeostasis.
Mon Mar 15 00:00:00 EDT 2021
Low-dose 2-deoxy glucose stabilises tolerogenic dendritic cells and generates potent in vivo immunosuppressive effects.
Cellular and molecular life sciences : CMLS
Christofi M,Le Sommer S,Mölzer C,Klaska IP,Kuffova L,Forrester JV
25-1152 was used in Flow cytometry/Cell sorting to show that low-dose 2 D-G (2.5 mM) (2-DGtolDC) induces a stable tolerogenic phenotype of mouse bone marrow-derived tolDC, ex vivo.
Mon Mar 01 00:00:00 EST 2021
Low-dose 2-deoxy glucose stabilises tolerogenic dendritic cells and generates potent in vivo immunosuppressive effects.
Cellular and molecular life sciences : CMLS
Christofi M,Le Sommer S,Mölzer C,Klaska IP,Kuffova L,Forrester JV
25-1152 was used in Flow cytometry/Cell sorting to show that low-dose 2 D-G (2.5 mM) (2-DGtolDC) induces a stable tolerogenic phenotype of mouse bone marrow-derived tolDC, ex vivo.
Mon Mar 01 00:00:00 EST 2021
HOXA11 plays critical roles in disease progression and response to cytarabine in AML.
Oncology reports
Fu JF,Shih LY,Yen TH
Published figure using CD115 (c-fms) monoclonal antibody (Product # 25-1152-82) in Flow Cytometry
Thu Jul 01 00:00:00 EDT 2021
Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy.
Journal of neuroinflammation
Oladiran O,Shi XQ,Yang M,Fournier S,Zhang J
Published figure using CD115 (c-fms) monoclonal antibody (Product # 25-1152-82) in Flow Cytometry
Mon Mar 22 00:00:00 EDT 2021
CX3CR1 But Not CCR2 Expression Is Required for the Development of Autoimmune Peripheral Neuropathy in Mice.
Frontiers in immunology
Oladiran O,Shi XQ,Fournier S,Zhang J
Published figure using CD115 (c-fms) monoclonal antibody (Product # 25-1152-82) in Flow Cytometry
Tue Dec 21 00:00:00 EST 2021
Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics.
eLife
Serrano-Lopez J,Hegde S,Kumar S,Serrano J,Fang J,Wellendorf AM,Roche PA,Rangel Y,Carrington LJ,Geiger H,Grimes HL,Luther S,Maillard I,Sanchez-Garcia J,Starczynowski DT,Cancelas JA
Published figure using CD115 (c-fms) monoclonal antibody (Product # 25-1152-82) in Flow Cytometry
Thu Apr 08 00:00:00 EDT 2021
Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia.
Molecular metabolism
La Rose AM,Bazioti V,Hoogerland JA,Svendsen AF,Groenen AG,van Faassen M,Rutten MGS,Kloosterhuis NJ,Dethmers-Ausema B,Nijland JH,Mithieux G,Rajas F,Kuipers F,Lukens MV,Soehnlein O,Oosterveer MH,Westerterp M
Published figure using CD115 (c-fms) monoclonal antibody (Product # 25-1152-82) in Flow Cytometry
Mon Nov 01 00:00:00 EDT 2021
Radiation causes tissue damage by dysregulating inflammasome-gasdermin D signaling in both host and transplanted cells.
PLoS biology
Xiao J,Wang C,Yao JC,Alippe Y,Yang T,Kress D,Sun K,Kostecki KL,Monahan JB,Veis DJ,Abu-Amer Y,Link DC,Mbalaviele G
Published figure using CD115 (c-fms) monoclonal antibody (Product # 25-1152-82) in Flow Cytometry
Sat Aug 01 00:00:00 EDT 2020
Temporospatial distribution and transcriptional profile of retinal microglia in the oxygen-induced retinopathy mouse model.
Glia
Boeck M,Thien A,Wolf J,Hagemeyer N,Laich Y,Yusuf D,Backofen R,Zhang P,Boneva S,Stahl A,Hilgendorf I,Agostini H,Prinz M,Wieghofer P,Schlunck G,Schlecht A,Lange C
25-1152 was used in Flow cytometry/Cell sorting to determine the extent of MG proliferation and M infiltration in areas with retinal ischemia and RNV in Cx3cr1CreERT2 :Rosa26-tdTomato mice and examine the transcriptional profile of MG in the mouse model of oxygen-induced retinopathy (OIR).
Tue Sep 01 00:00:00 EDT 2020
Temporospatial distribution and transcriptional profile of retinal microglia in the oxygen-induced retinopathy mouse model.
Glia
Boeck M,Thien A,Wolf J,Hagemeyer N,Laich Y,Yusuf D,Backofen R,Zhang P,Boneva S,Stahl A,Hilgendorf I,Agostini H,Prinz M,Wieghofer P,Schlunck G,Schlecht A,Lange C
25-1152 was used in Flow cytometry/Cell sorting to determine the extent of MG proliferation and M infiltration in areas with retinal ischemia and RNV in Cx3cr1CreERT2 :Rosa26-tdTomato mice and examine the transcriptional profile of MG in the mouse model of oxygen-induced retinopathy (OIR).
Tue Sep 01 00:00:00 EDT 2020
Androgen Receptor Signaling Positively Regulates Monocytic Development.
Frontiers in immunology
Consiglio CR,Gollnick SO
Published figure using CD115 (c-fms) monoclonal antibody (Product # 25-1152-82) in Flow Cytometry
Thu Apr 29 00:00:00 EDT 2021
Puerarin alters the function of monocytes/macrophages and exhibits chondroprotection in mice.
Molecular medicine reports
Peng L,Xie Z,Pei J,Wang B,Gao Y,Qu Y
25-1152 was used in Flow cytometry/Cell sorting to show puerarin may be a target in the treatment of osteoarthritis as administration diminished the recruitment of inflammatory monocytes in arthritic tissues.
Mon Apr 01 00:00:00 EDT 2019
Concomitant type I IFN and M-CSF signaling reprograms monocyte differentiation and drives pro-tumoral arginase production.
EBioMedicine
Tong Y,Zhou L,Yang L,Guo P,Cao Y,Qin FX,Liu J
Published figure using CD115 (c-fms) monoclonal antibody (Product # 25-1152-82) in Flow Cytometry
Tue Jan 01 00:00:00 EST 2019
Myeloid Folliculin balances mTOR activation to maintain innate immunity homeostasis.
JCI insight
Li J,Wada S,Weaver LK,Biswas C,Behrens EM,Arany Z
25-1152 was used in Flow cytometry/Cell sorting to investigate the effects of LPS on the tumour suppressor folliculin.
Thu Mar 07 00:00:00 EST 2019
Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cells.
Frontiers in immunology
Zwick M,Ulas T,Cho YL,Ried C,Grosse L,Simon C,Bernhard C,Busch DH,Schultze JL,Buchholz VR,Stutte S,Brocker T
25-1152-82 was used in Flow Cytometry to suggest that Ppef2 is crucial to support survival of immature CD8+ DCs, while Ppef2 down-regulation during DC-maturation limits T cell responses.
Tue Oct 27 00:00:00 EDT 2020
Bone loss in C57BL/6J-OlaHsd mice, a substrain of C57BL/6J carrying mutated alpha-synuclein and multimerin-1 genes.
Journal of cellular physiology
Liron T,Raphael B,Hiram-Bab S,Bab IA,Gabet Y
Published figure using CD115 (c-fms) monoclonal antibody (Product # 25-1152-82) in Flow Cytometry
Mon Jan 01 00:00:00 EST 2018
Captopril mitigates splenomegaly and myelofibrosis in the Gata1low murine model of myelofibrosis.
Journal of cellular and molecular medicine
Corey SJ,Jha J,McCart EA,Rittase WB,George J,Mattapallil JJ,Mehta H,Ognoon M,Bylicky MA,Summers TA,Day RM
Published figure using CD115 (c-fms) monoclonal antibody (Product # 25-1152-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2018
Neutrophil and Macrophage Cell Surface Colony-Stimulating Factor 1 Shed by ADAM17 Drives Mouse Macrophage Proliferation in Acute and Chronic Inflammation.
Molecular and cellular biology
Tang J,Frey JM,Wilson CL,Moncada-Pazos A,Levet C,Freeman M,Rosenfeld ME,Stanley ER,Raines EW,Bornfeldt KE
Published figure using CD115 (c-fms) monoclonal antibody (Product # 25-1152-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2018
Advanced Glycation End Products Enhance Murine Monocyte Proliferation in Bone Marrow and Prime Them into an Inflammatory Phenotype through MAPK Signaling.
Journal of diabetes research
Jin X,Liu L,Zhang Y,Xiang Y,Yin G,Lu Y,Shi L,Dong J,Shen C
Published figure using CD115 (c-fms) monoclonal antibody (Product # 25-1152-82) in Flow Cytometry
Wed Oct 10 00:00:00 EDT 2018
Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen.
Immunity
Lim HY,Lim SY,Tan CK,Thiam CH,Goh CC,Carbajo D,Chew SHS,See P,Chakarov S,Wang XN,Lim LH,Johnson LA,Lum J,Fong CY,Bongso A,Biswas A,Goh C,Evrard M,Yeo KP,Basu R,Wang JK,Tan Y,Jain R,Tikoo S,Choong C,Weninger W,Poidinger M,Stanley RE,Collin M,Tan NS,Ng LG,Jackson DG,Ginhoux F,Angeli V
25-1152-82 was used in Flow cytometry/Cell sorting to unveil a hitherto unknown homeostatic contribution of arterial LYVE-1+ macrophages through the control of collagen production by SMCs and has identified a function of LYVE-1 in leukocytes.
Tue Aug 21 00:00:00 EDT 2018
Erythropoietin enhances Kupffer cell number and activity in the challenged liver.
Scientific reports
Gilboa D,Haim-Ohana Y,Deshet-Unger N,Ben-Califa N,Hiram-Bab S,Reuveni D,Zigmond E,Gassmann M,Gabet Y,Varol C,Neumann D
Published figure using CD115 (c-fms) monoclonal antibody (Product # 25-1152-82) in Flow Cytometry
Mon Sep 04 00:00:00 EDT 2017
A new fate mapping system reveals context-dependent random or clonal expansion of microglia.
Nature neuroscience
Tay TL,Mai D,Dautzenberg J,Fernández-Klett F,Lin G,Datta M,Drougard A,Stempfl T,Ardura-Fabregat A,Staszewski O,Margineanu A,Sporbert A,Steinmetz LM,Pospisilik JA,Jung S,Priller J,Grün D,Ronneberger O,Prinz M
25-1152-82 was used in flow cytometry to suggest that microglia establish a dense network with regional differences, and the high regional turnover rates found challenge the universal concept of microglial longevity.
Thu Jun 01 00:00:00 EDT 2017
Enforced Expression of Hoxa3 Inhibits Classical and Promotes Alternative Activation of Macrophages In Vitro and In Vivo.
Journal of immunology (Baltimore, Md. : 1950)
Al Sadoun H,Burgess M,Hentges KE,Mace KA
25-1152 was used in Flow cytometry/Cell sorting to determine the involvement of Hoxa3 on macrophage maturation and polarisation in the diabetic wound.
Mon Aug 01 00:00:00 EDT 2016
PER1 prevents excessive innate immune response during endotoxin-induced liver injury through regulation of macrophage recruitment in mice.
Cell death & disease
Wang T,Wang Z,Yang P,Xia L,Zhou M,Wang S,Du J,Zhang J
Published figure using CD115 (c-fms) monoclonal antibody (Product # 25-1152-82) in Flow Cytometry
Thu Apr 07 00:00:00 EDT 2016
G-CSF regulates macrophage phenotype and associates with poor overall survival in human triple-negative breast cancer.
Oncoimmunology
Hollmén M,Karaman S,Schwager S,Lisibach A,Christiansen AJ,Maksimow M,Varga Z,Jalkanen S,Detmar M
25-1152 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms by which tumour-associated macrophages promote breast cancer growth and metastasis, showing that G-CSF regulates macrophage phenotype and is associated with poor survival.
Tue Mar 01 00:00:00 EST 2016
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.
Nature cell biology
Zhang Y,Yang P,Sun T,Li D,Xu X,Rui Y,Li C,Chong M,Ibrahim T,Mercatali L,Amadori D,Lu X,Xie D,Li QJ,Wang XF
Published figure using CD115 (c-fms) monoclonal antibody (Product # 25-1152-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
In vivo inhibition of c-MYC in myeloid cells impairs tumor-associated macrophage maturation and pro-tumoral activities.
PloS one
Pello OM,Chèvre R,Laoui D,De Juan A,Lolo F,Andrés-Manzano MJ,Serrano M,Van Ginderachter JA,Andrés V
Published figure using CD115 (c-fms) monoclonal antibody (Product # 25-1152-82) in Flow Cytometry
Mon Feb 25 00:00:00 EST 2013
Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis.
The Journal of biological chemistry
Chen Y,Wang X,Di L,Fu G,Chen Y,Bai L,Liu J,Feng X,McDonald JM,Michalek S,He Y,Yu M,Fu YX,Wen R,Wu H,Wang D
Published figure using CD115 (c-fms) monoclonal antibody (Product # 25-1152-82) in Flow Cytometry
Fri Oct 24 00:00:00 EDT 2008