Product References
In chronic lymphocytic leukemia, activation of the thrombopoietin receptor promotes T-cell inhibitory properties, contributing to immunosuppression.
European journal of haematology
Ringelstein-Harlev S,Fanadka M,Horowitz NA,Bettman NP,Katz T
12-4776-42 was used in Flow cytometry/Cell sorting to evaluate CLL cell-induced expression of TPO receptor (TPO-R) on T-cells and effects of its activation on T-cell responses.
Sat Apr 01 00:00:00 EDT 2023
Rapamycin improves Graves' orbitopathy by suppressing CD4+ cytotoxic T lymphocytes.
JCI insight
Zhang M,Chong KK,Chen ZY,Guo H,Liu YF,Kang YY,Li YJ,Shi TT,Lai KK,He MQ,Ye K,Kahaly GJ,Shi BY,Wang Y
12-4776-42 was used in Flow cytometry/Cell sorting to study the effect of rapamycin, an approved mTOR complex 1 (mTORC1) inhibitor, in a GO mouse model, in vitro, and in patients with refractory GO.
Wed Feb 08 00:00:00 EST 2023
Preventive effects of Mycobacterium tuberculosis DNA vaccines on the mouse model with latent tuberculosis infection.
Frontiers in immunology
Liang Y,Li X,Yang Y,Xiao L,Liang Y,Mi J,Xue Y,Gong W,Wang L,Wang J,Zhang J,Shi Y,Peng B,Chen X,Zhao W,Wu X
12-4776-42 was used in Flow cytometry/Cell sorting to provide candidates for the development of new multi-stage vaccines against TB.
Fri Mar 03 00:00:00 EST 2023
The clinicopathological significance and relapse predictive role of tumor microenvironment of intrahepatic cholangiocarcinoma after radical surgery.
Cancer
Zheng Y,Huang N,Kuang S,Zhang J,Zhao H,Wu J,Liu M,Wang L
12-4776-42 was used in Flow cytometry/Cell sorting to detect the expression of FoxP3, CD68, CD8α, and PD-L1 in the tumor microenvironment (TME) of intrahepatic cholangiocarcinoma (ICC), and analyze the relationship between the corresponding cells and clinicopathological characteristics as well as prognosis of ICC.
Wed Feb 01 00:00:00 EST 2023
Heterozygous premature termination in zinc-finger domain of Krüppel-like factor 2 gene associates with dysregulated immunity.
Frontiers in immunology
Pernaa N,Keskitalo S,Chowdhury I,Nissinen A,Glumoff V,Keski-Filppula R,Junttila J,Eklund KK,Santaniemi W,Siitonen S,Seppänen MR,Vähäsalo P,Varjosalo M,Åström P,Hautala T
12-4776-42 was used in Flow Cytometry experiments to conclude that KLF2 variant may be associated with familial immune dysregulation. Although the KLF2 deficient family members in our study suffered from lymphopenia, autoimmunity or malignancy, additional study cohorts are required to confirm our observations.
Tue Dec 06 00:00:00 EST 2022
Quantitative genome-scale metabolic modeling of human CD4+ T cell differentiation reveals subset-specific regulation of glycosphingolipid pathways.
Cell reports
Sen P,Andrabi SBA,Buchacher T,Khan MM,Kalim UU,Lindeman TM,Alves MA,Hinkkanen V,Kemppainen E,Dickens AM,Rasool O,Hyötyläinen T,Lahesmaa R,Orešič M
12-4776-42 was used in Flow Cytometry to provide a comprehensive resource for selective manipulation of CD4+ T cells under disease conditions characterized by an imbalance of Th17/natural Treg (nTreg) cells.
Tue Nov 09 00:00:00 EST 2021
Metabolic Disturbance and Th17/Treg Imbalance Are Associated With Progression of Gingivitis.
Frontiers in immunology
Wang W,Wang X,Lu S,Lv H,Zhao T,Xie G,Du Y,Fan Y,Xu L
12-4776-42 was used in Flow cytometry/Cell sorting to explore the role of metabolic disturbance in immunoregulation of gingivitis targeting T helper 17 cells/regulatory T cells.
Wed Oct 20 00:00:00 EDT 2021
hnRNPA1 enhances FOXP3 stability to promote the differentiation and functions of regulatory T cells.
FEBS letters
Liu X,Tian N,Huang Q,Xu Z,Cheng H,Liu X,Li D,Liang R,Li B,Dai X
12-4776-42 was used in Flow Cytometry to present a new role of hnRNPA1 in promoting Treg function, indicating it as a promising target for tumor therapies.
Thu Jul 01 00:00:00 EDT 2021
Taurine promotes the production of CD4+CD25+FOXP3+ Treg cells through regulating IL-35/STAT1 pathway in a mouse allergic rhinitis model.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
Zhou J,Lu Y,Wu W,Feng Y
12-4776-42 was used in Flow Cytometry to show that the restoration of Treg populations by taurine normalizes the inflammatory response, reduces AR symptomology, and reduces histopathologic signs of AR.
Sat Jun 19 00:00:00 EDT 2021
Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells.
Immunity
Śledzińska A,Vila de Mucha M,Bergerhoff K,Hotblack A,Demane DF,Ghorani E,Akarca AU,Marzolini MAV,Solomon I,Vargas FA,Pule M,Ono M,Seddon B,Kassiotis G,Ariyan CE,Korn T,Marafioti T,Lord GM,Stauss H,Jenner RG,Peggs KS,Quezada SA
12-4776 was used in Flow cytometry/Cell sorting to underscore the role of Treg cells, IL-2, and Blimp-1 in controlling the differentiation of cytotoxic CD4+ T cells and offer a pathway to enhancement of anti-tumor activity through their manipulation.
Tue Jan 14 00:00:00 EST 2020
Changes in lung immune cells related to clinical outcome during treatment with infliximab for sarcoidosis.
Clinical and experimental immunology
Kullberg S,Rivera NV,Abo Al Hayja M,Grunewald J,Eklund A
12-4776-42 was used in Flow Cytometry to evaluate the effects of treatment with the TNF-α inhibitor infliximab on lung immune cells.
Wed Jul 01 00:00:00 EDT 2020
Potential of neutrophil to lymphocyte ratio in predicting sustained remission in rheumatoid arthritis compared to other immune activation markers.
The Indian journal of medical research
Chandrashekara S,Lingaraju DC,Renuka P,Anupama KR
12-4776 was used in Flow cytometry/Cell sorting to evaluate the role of cytokines and the immunocompetent cells as biomarkers of remission in rheumatoid arthritis (RA) patients intended to withdraw or reduce disease-modifying anti-rheumatic drug (DMARD) treatment.
Tue Sep 01 00:00:00 EDT 2020
Comparative Study of Immunomodulatory Agents to Induce Human T Regulatory (Treg) Cells: Preferential Treg-Stimulatory Effect of Prednisolone and Rapamycin.
Archivum immunologiae et therapiae experimentalis
Janyst M,Kaleta B,Janyst K,Zagożdżon R,Kozlowska E,Lasek W
12-4776 was used in Flow cytometry/Cell sorting to compare the effectiveness of several immunomodulatory agents on human T regulatory cell development.
Fri Jun 12 00:00:00 EDT 2020
Role of Vitamins A and D in BCR-ABL Arf-/- Acute Lymphoblastic Leukemia.
Scientific reports
Annu K,Cline C,Yasuda K,Ganguly S,Pesch A,Cooper B,Janke L,Payton M,Mukherjee K,Surman SL,Hurwitz JL,Schuetz EG
12-4776-42 was used in Flow Cytometry to propose that vitamin A and D deficiencies have opposing effects on mouse survival from BCR-ABL acute lymphoblastic leukaemia.
Tue Feb 11 00:00:00 EST 2020
The effect of everolimus and low-dose cyclophosphamide on immune cell subsets in patients with metastatic renal cell carcinoma: results from a phase I clinical trial.
Cancer immunology, immunotherapy : CII
Huijts CM,Lougheed SM,Bodalal Z,van Herpen CM,Hamberg P,Tascilar M,Haanen JB,Verheul HM,de Gruijl TD,van der Vliet HJ
12-4776-42 was used in Flow Cytometry to show that cyclophosphamide once daily and continuously administered together with everolimus once daily, results in depletion of Tregs, and leads to a reduction in myeloid-derived suppressor cells, a sustained level of the CD8+ T-cell population accompanied by an increased effector to suppressor ratio, and reversal of negative effects on three peripheral blood dendritic cell subsets.
Fri Mar 01 00:00:00 EST 2019
The Effect of Age on the Immunogenicity of the Live Attenuated Zoster Vaccine Is Predicted by Baseline Regulatory T Cells and Varicella-Zoster Virus-Specific T Cell Immunity.
Journal of virology
Weinberg A,Pang L,Johnson MJ,Caldas Y,Cho A,Tovar-Salazar A,Canniff J,Schmader KE,Popmihajlov Z,Levin MJ
12-4776 was used in Flow cytometry/Cell sorting to understand the the factors affecting the magnitude and kinetics of T cell responses to live attenuated zoster vaccine (ZVL) in older adults and show the importance of prevaccination Treg and Tcheck in modulating the immunogenicity of ZVL.
Thu Aug 01 00:00:00 EDT 2019
T-Lymphocyte Subset Distribution and Activity in Patients With Glaucoma.
Investigative ophthalmology & visual science
Yang X,Zeng Q,Göktas E,Gopal K,Al-Aswad L,Blumberg DM,Cioffi GA,Liebmann JM,Tezel G
12-4776-42 was used in Flow Cytometry to analyse T lymphocytes in patients’ blood, to explore the T-cell– mediated component of systemic immunity.
Fri Mar 01 00:00:00 EST 2019
Regulatory T cells from patients with end-stage organ disease can be isolated, expanded and cryopreserved according good manufacturing practice improving their function.
Journal of translational medicine
Ulbar F,Montemurro T,Jofra T,Capri M,Comai G,Bertuzzo V,Lavazza C,Mandelli A,Viganò M,Budelli S,Bacalini MG,Pirazzini C,Garagnani P,Giudice V,Sollazzo D,Curti A,Arpinati M,La Manna G,Cescon M,Pinna AD,Franceschi C,Battaglia M,Giordano R,Catani L,Lemoli RM
12-4776-42 was used in Flow Cytometry to demonstrate that expanded/thawed regulatory T cells from patients with end-stage organ disease are fully functional in vitro and reduce lethality of acute GVHD in vivo.
Mon Aug 05 00:00:00 EDT 2019
Bioinformatic analysis of peripheral blood RNA-sequencing sensitively detects the cause of late graft loss following overt hyperglycemia in pig-to-nonhuman primate islet xenotransplantation.
Scientific reports
Kim HJ,Moon JH,Chung H,Shin JS,Kim B,Kim JM,Kim JS,Yoon IH,Min BH,Kang SJ,Kim YH,Jo K,Choi J,Chae H,Lee WW,Kim S,Park CG
12-4776 was used in Flow cytometry/Cell sorting to analyse the gene expression profles in 2 rhesus monkey recipients using peripheral blood RNA-sequencing (RNA-seq) data to fnd out the potential cause(s) of late graft loss.
Wed Dec 11 00:00:00 EST 2019
Vitamin D supplementation during pregnancy: Effect on the neonatal immune system in a randomized controlled trial.
The Journal of allergy and clinical immunology
Hornsby E,Pfeffer PE,Laranjo N,Cruikshank W,Tuzova M,Litonjua AA,Weiss ST,Carey VJ,O'Connor G,Hawrylowicz C
12-4776 was used in Flow cytometry/Cell sorting to investigate the effect on neonatal immunity of maternal supplementation with 4400 IU/d vitamin D3 during the second and third trimesters of pregnancy by using a subset of cord blood samples from a randomized, double-blind, placebo-controlled clinical trial.
Mon Jan 01 00:00:00 EST 2018
Human Immunodeficiency Virus Type-1 Elite Controllers Maintain Low Co-Expression of Inhibitory Receptors on CD4+ T Cells.
Frontiers in immunology
Noyan K,Nguyen S,Betts MR,Sönnerborg A,Buggert M
12-4776 was used in Flow cytometry/Cell sorting to suggest that ELCs harbor a "healthy" state of inhibitory receptor expression on CD4+ T cells that might play part in maintenance of their control status.
Thu Feb 14 00:00:00 EST 2019
A highly potent and selective inhibitor Roxyl-WL targeting IDO1 promotes immune response against melanoma.
Journal of enzyme inhibition and medicinal chemistry
Xu G,Wang T,Li Y,Huang Z,Wang X,Zheng J,Yang S,Fan Y,Xiang R
Sat Dec 01 00:00:00 EST 2018
The Genetic Polymorphisms of NLRP3 Inflammasome Associated with T Helper Cells in Patients with Multiple Myeloma.
Journal of immunology research
Zhao X,Hua M,Yan S,Yu J,Han F,Zhong C,Wang R,Zhang C,Hou M,Ma D
Fri Nov 09 00:00:00 EST 2018
Mesenchymal stromal cells from myelodysplastic and acute myeloid leukemia patients display in vitro reduced proliferative potential and similar capacity to support leukemia cell survival.
Stem cell research & therapy
Corradi G,Baldazzi C,Očadlíková D,Marconi G,Parisi S,Testoni N,Finelli C,Cavo M,Curti A,Ciciarello M
12-4776 was used in Flow cytometry/Cell sorting to compare mesenchymal stromal cells isolated from healthy, myelodysplastic syndrome, and acute myeloid leukaemia subjects to investigate MSC alterations and to emphasise putative common and/or diverse features.
Thu Oct 25 00:00:00 EDT 2018
CD226 opposes TIGIT to disrupt Tregs in melanoma.
JCI insight
Fourcade J,Sun Z,Chauvin JM,Ka M,Davar D,Pagliano O,Wang H,Saada S,Menna C,Amin R,Sander C,Kirkwood JM,Korman AJ,Zarour HM
12-4776 was used in Flow cytometry/Cell sorting to study if a high TIGIT/CD226 ratio in Tregs regulate their suppressive function and stability in melanoma.
Thu Jul 26 00:00:00 EDT 2018
Decidual T Cells Exhibit a Highly Differentiated Phenotype and Demonstrate Potential Fetal Specificity and a Strong Transcriptional Response to IFN.
Journal of immunology (Baltimore, Md. : 1950)
Powell RM,Lissauer D,Tamblyn J,Beggs A,Cox P,Moss P,Kilby MD
12-4776 was used in Flow cytometry/Cell sorting to investigate the specificity and regulation of CD4+ and CD8+ T cells obtained from human third trimester decidua and demonstrated that decidual CD4+ and CD8+ T cells exhibit a highly differentiated effector memory phenotype in comparison with peripheral blood.
Wed Nov 15 00:00:00 EST 2017
Augmented Th17-type immune responses in preterm neonates exposed to histologic chorioamnionitis.
Pediatric research
Rito DC,Viehl LT,Buchanan PM,Haridas S,Koenig JM
12-4776 was used in Flow cytometry/Cell sorting to speculate that a Th17 bias may potentiate the inflammatory responses and related morbidity observed in preterm neonates whose immune systems have been "primed" by HCA exposure.
Sat Apr 01 00:00:00 EDT 2017
Differences in Peripheral Blood Lymphocytes between Brand-Name and Generic Tacrolimus Used in Stable Liver Transplant Recipients.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre
Kim JM,Kwon CHD,Joh JW,Sinn DH,Choi GS,Park JB,Kang ES,Lee SK
12477642 was used in flow cytometry to characterize the periferal blood lymphocytes phenotype in tacrolimus-treated liver transplanted patients.
Mon Mar 19 00:00:00 EDT 2018
Bilirubin suppresses Th17 immunity in colitis by upregulating CD39.
JCI insight
Longhi MS,Vuerich M,Kalbasi A,Kenison JE,Yeste A,Csizmadia E,Vaughn B,Feldbrugge L,Mitsuhashi S,Wegiel B,Otterbein L,Moss A,Quintana FJ,Robson SC
12-4776 was used in Flow cytometry/Cell sorting to discover that the immunosuppressive effects of unconjugated bilirubinare mediated by an aryl hydrocarbon receptor results in CD39 upregulation by Th17.
Thu May 04 00:00:00 EDT 2017
Analysis of long term CD4+CD25highCD127- T-reg cells kinetics in peripheral blood of lung transplant recipients.
BMC pulmonary medicine
Piloni D,Morosini M,Magni S,Balderacchi A,Scudeller L,Cova E,Oggionni T,Stella G,Tinelli C,Antonacci F,D'Armini AM,Meloni F
12-4776 was used in Flow cytometry/Cell sorting to analyse long term peripheral kinetics of T-reg-cells in a cohort of lung recipients and tests its association to several clinical variables.
Tue Jul 18 00:00:00 EDT 2017
Cytomegalovirus infection in HIV-infected and uninfected individuals is characterized by circulating regulatory T cells of unconstrained antigenic specificity.
PloS one
Tovar-Salazar A,Weinberg A
12-4776 was used in Flow cytometry/Cell sorting to indicate that CMV-seropositive individuals have circulating Tregs that inhibit cell-mediated immune responses to CMV and other antigens and may be contribute to an immune-suppressive effect of CMV infection.
Fri Oct 06 00:00:00 EDT 2017
TGF-beta/atRA-induced Tregs express a selected set of microRNAs involved in the repression of transcripts related to Th17 differentiation.
Scientific reports
Schiavinato JLDS,Haddad R,Saldanha-Araujo F,Baiochi J,Araujo AG,Santos Scheucher P,Covas DT,Zago MA,Panepucci RA
12-4776 was used in Flow cytometry/Cell sorting to explore the roles of individual microRNAs involved in the repression of transcripts related to Th17 differentiation in regulatory T cells.
Thu Jun 15 00:00:00 EDT 2017
The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements.
Immunity
Procaccini C,Carbone F,Di Silvestre D,Brambilla F,De Rosa V,Galgani M,Faicchia D,Marone G,Tramontano D,Corona M,Alviggi C,Porcellini A,La Cava A,Mauri P,Matarese G
12-4776 was used in Flow cytometry/Cell sorting to provide a molecular picture of the impact of metabolism on ex vivo human Treg versus Tconv cell functions.
Tue Feb 16 00:00:00 EST 2016
Clinical Observation of Employment of Umbilical Cord Derived Mesenchymal Stem Cell for Juvenile Idiopathic Arthritis Therapy.
Stem cells international
Wang L,Zhang Y,Li H,Hong J,Chen X,Li M,Bai W,Wang J,Liu Y,Wu M
12-4776 was used in Flow cytometry/Cell sorting to explore the therapeutic effect of umbilical cord mesenchymal stem cells for Juvenile Idiopathic Arthritis.
Fri Jan 15 00:00:00 EST 2016
CCL20-CCR6 Cytokine Network Facilitate Treg Activity in Advanced Grades and Metastatic Variants of Hepatocellular Carcinoma.
Scandinavian journal of immunology
Li WM,Liu HR
12-4776 was used in Flow cytometry/Cell sorting to study the expression of cytokines potentially known to recruit regulatory T cells in hepatocellular carcinoma.
Fri Jan 01 00:00:00 EST 2016
FOXP3+ associated with the pro-inflammatory regulatory T and T helper 17 effector cells in asthma patients.
Experimental and therapeutic medicine
Zhang JG,Chen XJ,Liu T,Jiang SJ
12-4776 was used in Flow cytometry/Cell sorting to evaluate whether peripheral blood samples from asthma patients contain reduced Treg cells and increased Th17 cells.
Sat Oct 01 00:00:00 EDT 2016
Regulatory T Cells in Patients with Idiopathic Thrombocytopenic Purpura.
Turkish journal of haematology : official journal of Turkish Society of Haematology
Akyol Erikçi A,Karagöz B,Bilgi O
12-4776 was used in Flow cytometry/Cell sorting to investigate the role of regulatory T Cells in patients with Idiopathic Thrombocytopenic Purpura.
Sun Jun 05 00:00:00 EDT 2016
Regulatory T Cells and Vitamin D Status in Children with Chronic Autoimmune Thyroiditis.
Journal of clinical research in pediatric endocrinology
Şıklar Z,Karataş D,Doğu F,Hacıhamdioğlu B,İkincioğulları A,Berberoğlu M
12-4776 was used in Flow cytometry/Cell sorting to investigate the relationship between Treg cells and vitamin D levels in pediatric chronic autoimmune thyroiditis patients.
Thu Sep 01 00:00:00 EDT 2016
Function of Treg Cells Decreased in Patients With Systemic Lupus Erythematosus Due To the Effect of Prolactin.
Medicine
Legorreta-Haquet MV,Chávez-Rueda K,Chávez-Sánchez L,Cervera-Castillo H,Zenteno-Galindo E,Barile-Fabris L,Burgos-Vargas R,Álvarez-Hernández E,Blanco-Favela F
12-4776 was used in Flow cytometry/Cell sorting to investigate the role of prolactin in Treg-mediated immune response, showing that it decreased Treg function in patients with systemic Lupus Erythematosus.
Mon Feb 01 00:00:00 EST 2016
Earlier infantile immune maturation is related to higher DTP vaccine responses in children.
Clinical & translational immunology
Strömbeck A,Lundell AC,Nordström I,Andersson K,Adlerberth I,Wold AE,Rudin A
12-4776 was used in Flow cytometry/Cell sorting to suggest that children with a more activated adaptive immunity respond with higher DTP vaccine-induced antibody levels at 18 months of age.
Tue Mar 01 00:00:00 EST 2016
Dexamethasone co-medication in cancer patients undergoing chemotherapy causes substantial immunomodulatory effects with implications for chemo-immunotherapy strategies.
Oncoimmunology
Cook AM,McDonnell AM,Lake RA,Nowak AK
12-4776 was used in Flow cytometry/Cell sorting to investigate the immunological changes induced by co-medications, ushc as dexamethasone, commonly used in the clinic.
Tue Mar 01 00:00:00 EST 2016
Delayed adaptive immunity is related to higher MMR vaccine-induced antibody titers in children.
Clinical & translational immunology
Strömbeck A,Lundell AC,Nordström I,Andersson K,Adlerberth I,Wold AE,Rudin A
12-4776 was used in Flow cytometry/Cell sorting to investigate whether early environmental factors and adaptive immune maturation near to MMR immunization correlated with vaccine-specific antibody titres.
Fri Apr 01 00:00:00 EDT 2016
Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy.
Oncotarget
Williams GS,Mistry B,Guillard S,Ulrichsen JC,Sandercock AM,Wang J,González-Muñoz A,Parmentier J,Black C,Soden J,Freeth J,Jovanović J,Leyland R,Al-Lamki RS,Leishman AJ,Rust SJ,Stewart R,Jermutus L,Bradley JR,Bedian V,Valge-Archer V,Minter R,Wilkinson RW
12-4776 was used in Flow cytometry/Cell sorting to identify a novel mechanism for TNF-α-independent TNFR2 agonism in cancer immunotherapy.
Tue Oct 18 00:00:00 EDT 2016
Human ectonucleotidase-expressing CD25high Th17 cells accumulate in breast cancer tumors and exert immunosuppressive functions.
Oncoimmunology
Thibaudin M,Chaix M,Boidot R,Végran F,Derangère V,Limagne E,Berger H,Ladoire S,Apetoh L,Ghiringhelli F
12-4776 was used in Flow cytometry to show that human memory CD25high Th17 cells suppress T cell immunity in breast cancer.
Tue Jan 12 00:00:00 EST 2021
Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants.
Nature immunology
De Rosa V,Galgani M,Porcellini A,Colamatteo A,Santopaolo M,Zuchegna C,Romano A,De Simone S,Procaccini C,La Rocca C,Carrieri PB,Maniscalco GT,Salvetti M,Buscarinu MC,Franzese A,Mozzillo E,La Cava A,Matarese G
Sun Nov 01 00:00:00 EDT 2015
Decline of FoxP3+ Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria.
PLoS pathogens
Boyle MJ,Jagannathan P,Farrington LA,Eccles-James I,Wamala S,McIntyre TI,Vance HM,Bowen K,Nankya F,Auma A,Nalubega M,Sikyomu E,Naluwu K,Rek J,Katureebe A,Bigira V,Kapisi J,Tappero J,Muhindo MK,Greenhouse B,Arinaitwe E,Dorsey G,Kamya MR,Feeney ME
12-4776 was used in Flow cytometry/Cell sorting to demonstrate that chronic malaria exposure results in altered regulatory CD4 T cell homeostasis, which may impact development of antimalarial immunity.
Wed Jul 01 00:00:00 EDT 2015
The immunosuppressive enzyme IL4I1 promotes FoxP3(+) regulatory T lymphocyte differentiation.
European journal of immunology
Cousin C,Aubatin A,Le Gouvello S,Apetoh L,Castellano F,Molinier-Frenkel V
12-4776 was used in Flow cytometry/Cell sorting to study the effect of IL4I1 on naive CD4+ T cell differentiation.
Mon Jun 01 00:00:00 EDT 2015
Monitoring regulatory T cells in clinical samples: consensus on an essential marker set and gating strategy for regulatory T cell analysis by flow cytometry.
Cancer immunology, immunotherapy : CII
Santegoets SJ,Dijkgraaf EM,Battaglia A,Beckhove P,Britten CM,Gallimore A,Godkin A,Gouttefangeas C,de Gruijl TD,Koenen HJ,Scheffold A,Shevach EM,Staats J,Taskén K,Whiteside TL,Kroep JR,Welters MJ,van der Burg SH
12-4776 was used in Flow cytometry/Cell sorting to exhibit a novel strategy and system for the context-dependent analysis of Tregs.
Thu Oct 01 00:00:00 EDT 2015
Enhancement of the immunoregulatory potency of mesenchymal stromal cells by treatment with immunosuppressive drugs.
Cytotherapy
Girdlestone J,Pido-Lopez J,Srivastava S,Chai J,Leaver N,Galleu A,Lombardi G,Navarrete CV
12-4776-42 was used in Magnetic cell separation to show that brief incubations with rapamycin, everolimus, FK506 or cyclosporine A increase the immunosuppressive potency of mesenchymal stromal cells.
Tue Sep 01 00:00:00 EDT 2015
Durable complete responses off all treatment in patients with metastatic malignant melanoma after sequential immunotherapy followed by a finite course of BRAF inhibitor therapy.
Cancer biology & therapy
Wyluda EJ,Cheng J,Schell TD,Haley JS,Mallon C,Neves RI,Robertson G,Sivik J,Mackley H,Talamo G,Drabick JJ
12-4776 was used in Flow cytometry/Cell sorting to study the effectiveness of different therapy regimes on treating melanoma after failure of immunotherapy.
Tue Mar 01 00:00:00 EST 2016
CD4+CD25hiFOXP3+ Regulatory T Cells and Cytokine Responses in Human Schistosomiasis before and after Treatment with Praziquantel.
PLoS neglected tropical diseases
Schmiedel Y,Mombo-Ngoma G,Labuda LA,Janse JJ,de Gier B,Adegnika AA,Issifou S,Kremsner PG,Smits HH,Yazdanbakhsh M
12-4776 was used in Flow cytometry/Cell sorting to investigate Treg functional capacity during human Schistosoma haematobium infection.
Sat Aug 01 00:00:00 EDT 2015
Increased Intraepithelial Vα24 Invariant NKT Cells in the Celiac Duodenum.
Nutrients
Montalvillo E,Bernardo D,Martínez-Abad B,Allegretti Y,Fernández-Salazar L,Calvo C,Chirdo FG,Garrote JA,Arranz E
12-4776 was used in Flow cytometry/Cell sorting to study whether the number of Vα24-restricted iNKT cells is altered in the duodenum of untreated- or gluten free diet-coeliac disease patients.
Fri Oct 30 00:00:00 EDT 2015
Distribution of Peripheral Memory T Follicular Helper Cells in Patients with Schistosomiasis Japonica.
PLoS neglected tropical diseases
Chen X,Li W,Zhang Y,Song X,Xu L,Xu Z,Zhou S,Zhu J,Jin X,Liu F,Chen G,Su C
12-4776 was used in Flow cytometry/Cell sorting to characterise peripheral memory T follicular helper cells in schistosomiasis patients.
Fri Apr 22 00:00:00 EDT 2016
Improved Natural Killer cell activity and retained anti-tumor CD8(+) T cell responses contribute to the induction of a pathological complete response in HER2-positive breast cancer patients undergoing neoadjuvant chemotherapy.
Journal of translational medicine
Muraro E,Comaro E,Talamini R,Turchet E,Miolo G,Scalone S,Militello L,Lombardi D,Spazzapan S,Perin T,Massarut S,Crivellari D,Dolcetti R,Martorelli D
12-4776 was used in Flow cytometry/Cell sorting to indicate that maintenance of functional T cell responses against selected antigens and improvement of NK cell proficiency during NC are probably critical requirements for pCR induction.
Sat Jun 27 00:00:00 EDT 2015
The disturbance of TH17-Treg cell balance in adenomyosis.
Fertility and sterility
Gui T,Chen C,Zhang Z,Tang W,Qian R,Ma X,Cao P,Wan G
12-4776 was used in Flow cytometry/Cell sorting to investigate the balance between Treg and T(H)17 cells in peripheral blood and uteri of women with adenomyosis.
Sat Feb 01 00:00:00 EST 2014
High proportions of FOXP3(+) CD25(high) T cells in neonates are positively associated with allergic sensitization later in childhood.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Strömbeck A,Rabe H,Lundell AC,Andersson K,Johansen S,Adlerberth I,Wold AE,Hesselmar B,Rudin A
12-4776 was used in Flow cytometry/Cell sorting to indicate that high proportions of FOXP3(+) CD25(high) T-cells in neonates are not protective against later sensitization or development of allergy.
Tue Jul 01 00:00:00 EDT 2014
Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production.
PloS one
Lowe MM,Mold JE,Kanwar B,Huang Y,Louie A,Pollastri MP,Wang C,Patel G,Franks DG,Schlezinger J,Sherr DH,Silverstone AE,Hahn ME,McCune JM
12-4776 was used in Flow cytometry/Cell sorting to study the link between tryptophan metabolism and AHR activation and define a novel endogenous AHR agonist with potentially broad biological functions.
Mon Oct 20 00:00:00 EDT 2014
Adoptive immunotherapy with MUC1-mRNA transfected dendritic cells and cytotoxic lymphocytes plus gemcitabine for unresectable pancreatic cancer.
Journal of translational medicine
Shindo Y,Hazama S,Maeda Y,Matsui H,Iida M,Suzuki N,Yoshimura K,Ueno T,Yoshino S,Sakai K,Suehiro Y,Yamasaki T,Hinoda Y,Oka M
12-4776 was used in Flow cytometry/Cell sorting to investigate the effect of combination therapy of adoptive immunotherapy with gemcitabine on pancreatic cancer.
Thu Jun 19 00:00:00 EDT 2014
A method for conducting suppression assays using small numbers of tissue-isolated regulatory T cells.
MethodsX
Ward ST,Li KK,Curbishley SM
12-4776 was used in Flow cytometry/Cell sorting to describe a method to isolate Treg cells from human tissues and assess the suppressive capacity of Treg cell subsets.
Sat Jan 29 00:00:00 EST 2022
An increased abundance of tumor-infiltrating regulatory T cells is correlated with the progression and prognosis of pancreatic ductal adenocarcinoma.
PloS one
Tang Y,Xu X,Guo S,Zhang C,Tang Y,Tian Y,Ni B,Lu B,Wang H
12-4776 was used in Flow cytometry/Cell sorting to reveal Tregs may promote PDA progression by inhibiting the antitumour immunity of CD8+ T cells at local intratumoural sites.
Tue Jan 06 00:00:00 EST 2015
Regulatory T cells expanded from HIV-1-infected individuals maintain phenotype, TCR repertoire and suppressive capacity.
PloS one
Angin M,Klarenbeek PL,King M,Sharma SM,Moodley ES,Rezai A,Piechocka-Trocha A,Toth I,Chan AT,Goulder PJ,Ndung'u T,Kwon DS,Addo MM
12-4776 was used in Flow cytometry/Cell sorting to demonstrate that Tregs can be expanded from blood and tissue compartments of HIV-1+ donors with preservation of Treg phenotype, function and TCR repertoire.
Wed Dec 03 00:00:00 EST 2014
Subinfectious hepatitis C virus exposures suppress T cell responses against subsequent acute infection.
Nature medicine
Park SH,Veerapu NS,Shin EC,Biancotto A,McCoy JP,Capone S,Folgori A,Rehermann B
12-4776 was used in Flow cytometry/Cell sorting to investigate the effect of subinfectious exposure to hepatitis C virus on T cell-mediated protection.
Sun Dec 01 00:00:00 EST 2013
Ribavirin Does Not Impair the Suppressive Activity of Foxp3(+)CD4(+)CD25(+) Regulatory T Cells.
Immune network
Lee J,Choi YS,Shin EC
12-4776 was used in Immunofluorescence to demonstrate that ribavirin did not attenuate the suppressive activity of Foxp3(+)CD4(+)CD25(+) Treg cells.
Fri Feb 01 00:00:00 EST 2013
Protein kinase C inhibitor generates stable human tolerogenic dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Matsumoto T,Hasegawa H,Onishi S,Ishizaki J,Suemori K,Yasukawa M
12-4776 was used in Flow cytometry/Cell sorting to study how high production of IL-10 in PKCI-treated DCs was due to not only an increase of intracellular cAMP, but also a synergistic effect of increased cAMP and NF-κB inhibition.
Sun Sep 01 00:00:00 EDT 2013
Cross talk between follicular Th cells and tumor cells in human follicular lymphoma promotes immune evasion in the tumor microenvironment.
Journal of immunology (Baltimore, Md. : 1950)
Rawal S,Chu F,Zhang M,Park HJ,Nattamai D,Kannan S,Sharma R,Delgado D,Chou T,Lin HY,Baladandayuthapani V,Luong A,Vega F,Fowler N,Dong C,Davis RE,Neelapu SS
12-4776 was used in Flow cytometry/Cell sorting to provide novel insights into the cross talk among follicular Th cells, tumor cells, and Tregs in follicular lymphoma.
Sat Jun 15 00:00:00 EDT 2013
Elevated levels of CD4(+)CD25(+)FoxP3(+) T cells in systemic sclerosis patients contribute to the secretion of IL-17 and immunosuppression dysfunction.
PloS one
Liu X,Gao N,Li M,Xu D,Hou Y,Wang Q,Zhang G,Sun Q,Zhang H,Zeng X
12-4776 was used in Flow cytometry/Cell sorting to investigate the role of Treg subsets in the immune imbalance in naive systemic sclerosis (SSc), showing that elevated levels of CD4(+)CD25(+)FoxP3(+) T cells contribute to the secretion of IL-17 and immunosuppression dysfunction.
Thu Jan 16 00:00:00 EST 2014
Naive T cells are dispensable for memory CD4+ T cell homeostasis in progressive simian immunodeficiency virus infection.
The Journal of experimental medicine
Okoye AA,Rohankhedkar M,Abana C,Pattenn A,Reyes M,Pexton C,Lum R,Sylwester A,Planer SL,Legasse A,Park BS,Piatak M,Lifson JD,Axthelm MK,Picker LJ
12-4776 was used in Flow cytometry/Cell sorting to demonstrate that the CD4(+) naive T cell compartment is dispensable for CD4(+) memory T cell homeostasis in progressive simian immunodeficiency virus infection.
Mon Apr 09 00:00:00 EDT 2012
Phenotypic complexity of T regulatory subsets in patients with B-chronic lymphocytic leukemia.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Biancotto A,Dagur PK,Fuchs JC,Wiestner A,Bagwell CB,McCoy JP
12-4776 was used in Flow cytometry/Cell sorting to show that T(reg) cells can be divided into multiple complex subsets based on a number of markers.
Wed Feb 01 00:00:00 EST 2012
Whole-body UVB irradiation during allogeneic hematopoietic cell transplantation is safe and decreases acute graft-versus-host disease.
The Journal of investigative dermatology
Kreutz M,Karrer S,Hoffmann P,Gottfried E,Szeimies RM,Hahn J,Edinger M,Landthaler M,Andreesen R,Merad M,Holler E
12-4776 was used in Flow cytometry/Cell sorting to suggest that prophylactic UVB irradiation post transplant is safe and has potential to prevent acute GvHD.
Sun Jan 01 00:00:00 EST 2012
Induction of endometriosis alters the peripheral and endometrial regulatory T cell population in the non-human primate.
Human reproduction (Oxford, England)
Braundmeier A,Jackson K,Hastings J,Koehler J,Nowak R,Fazleabas A
12-4776 was used in Flow cytometry/Cell sorting to study how inducing endometriosis can alter the regulatory T cell population in the non-human primate.
Fri Jun 01 00:00:00 EDT 2012
Programmed death-1+ T cells and regulatory T cells are enriched in tumor-involved lymph nodes and associated with aggressive features in papillary thyroid cancer.
The Journal of clinical endocrinology and metabolism
French JD,Kotnis GR,Said S,Raeburn CD,McIntyre RC,Klopper JP,Haugen BR
12-4776 was used in Flow cytometry/Cell sorting to characterise the CD4(+) T cell response to metastatic PTC.
Fri Jun 01 00:00:00 EDT 2012
Infant B cell memory differentiation and early gut bacterial colonization.
Journal of immunology (Baltimore, Md. : 1950)
Lundell AC,Björnsson V,Ljung A,Ceder M,Johansen S,Lindhagen G,Törnhage CJ,Adlerberth I,Wold AE,Rudin A
12-4776 was used in Flow cytometry/Cell sorting to suggest that the intestinal bacterial colonization pattern may affect the B cell maturation also in humans, and that an early gut microbiota including E. coli and bifidobacteria might promote this maturation.
Tue May 01 00:00:00 EDT 2012
Prolactin down-regulates CD4+CD25hiCD127low/- regulatory T cell function in humans.
Journal of molecular endocrinology
Legorreta-Haquet MV,Chávez-Rueda K,Montoya-Díaz E,Arriaga-Pizano L,Silva-García R,Chávez-Sánchez L,Moreno-Lafont M,Zenteno-Galindo E,Blanco-Favela F
12-4776 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which prolactin regulates Tregs, showing that it down-regulates CD4+CD25hiCD127low/- regulatory T cell function.
Wed Feb 01 00:00:00 EST 2012
Seasonal variation in vitamin D₃ levels is paralleled by changes in the peripheral blood human T cell compartment.
PloS one
Khoo AL,Koenen HJ,Chai LY,Sweep FC,Netea MG,van der Ven AJ,Joosten I
12-4776 was used in Flow cytometry/Cell sorting to reveal that seasonal fluctuations in vitamin D3 levels may partially explain seasonal variation in immune status.
Mon May 14 00:00:00 EDT 2012
Absolute lymphocyte count is associated with survival in ovarian cancer independent of tumor-infiltrating lymphocytes.
Journal of translational medicine
Milne K,Alexander C,Webb JR,Sun W,Dillon K,Kalloger SE,Gilks CB,Clarke B,Köbel M,Nelson BH
12-4776 was used in Flow cytometry/Cell sorting to investigate how ALC values might be associated with stronger tumor immunity as manifested by increased TIL, decreased tumor burden and longer survival.
Mon Feb 27 00:00:00 EST 2012
The impact of vitamin D deficiency on immune T cells in asthmatic children: a case-control study.
Journal of asthma and allergy
Maalmi H,Berraïes A,Tangour E,Ammar J,Abid H,Hamzaoui K,Hamzaoui A
12-4776 was used in Flow cytometry/Cell sorting to suggest that vitamin D is an important promoter of T cell regulation in vivo in young asthmatics.
Tue Oct 02 00:00:00 EDT 2012
Lymphocyte subpopulations in lymph nodes and peripheral blood: a comparison between patients with stable angina and acute coronary syndrome.
PloS one
Backteman K,Andersson C,Dahlin LG,Ernerudh J,Jonasson L
12-4776 was used in Flow cytometry/Cell sorting to examine and compare the distribution of lymphocyte subpopulations in thoracic lymph nodes from patients with stable angina and acute coronary syndrome.
Mon Jul 23 00:00:00 EDT 2012
Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies.
Cellular & molecular immunology
Jiang Y,Li W,Yu L,Liu J,Xin G,Yan H,Sun P,Zhang H,Xu D,Niu J
12-4776 was used in Flow cytometry/Cell sorting to study the underlying immune mechanism in the antiviral response of patients treated with nucleoside or nucleotide analogues.
Sat Jan 01 00:00:00 EST 2011
A different immunologic profile characterizes patients with HER-2-overexpressing and HER-2-negative locally advanced breast cancer: implications for immune-based therapies.
Breast cancer research : BCR
Muraro E,Martorelli D,Turchet E,Miolo G,Scalone S,Comaro E,Talamini R,Mastorci K,Lombardi D,Perin T,Carbone A,Veronesi A,Crivellari D,Dolcetti R
12-4776 was used in Flow cytometry/Cell sorting to demonstrate that patients with HER2-overexpressing locally advanced breast cancer show more limited tumour-related immune suppression than HER2- patients.
Mon Jun 25 00:00:00 EDT 2012
CD4+ T cells, including Th17 and cycling subsets, are intact in the gut mucosa of HIV-1-infected long-term nonprogressors.
Journal of virology
Ciccone EJ,Greenwald JH,Lee PI,Biancotto A,Read SW,Yao MA,Hodge JN,Thompson WL,Kovacs SB,Chairez CL,Migueles SA,Kovacs JA,Margolis LB,Sereti I
12-4776 was used in Flow cytometry/Cell sorting to identify that long-term HIV infected nonprogressors preserve the balance of CD4(+) T cell populations in blood and gut mucosa.
Wed Jun 01 00:00:00 EDT 2011
Higher proportions of circulating FOXP3+ and CTLA-4+ regulatory T cells are associated with lower fractions of memory CD4+ T cells in infants.
Journal of leukocyte biology
Rabe H,Lundell AC,Andersson K,Adlerberth I,Wold AE,Rudin A
12-4776 was used in Flow cytometry/Cell sorting to conclude that FOXP3(+) or CTLA-4(+) Tregs may modulate CD4(+) T cell activation and homing receptor expression in children.
Thu Dec 01 00:00:00 EST 2011
Anticardiac myosin immunity and chronic allograft vasculopathy in heart transplant recipients.
Journal of immunology (Baltimore, Md. : 1950)
Kalache S,Dinavahi R,Pinney S,Mehrotra A,Cunningham MW,Heeger PS
12-4776 was used in Flow cytometry/Cell sorting to investigate the pathogenesis of chronic allograft vasculopathy in heart transplant failure.
Fri Jul 15 00:00:00 EDT 2011
Choice of resident costimulatory molecule can influence cell fate in human naïve CD4+ T cell differentiation.
Cellular immunology
Williams KM,Dotson AL,Otto AR,Kohlmeier JE,Benedict SH
12-4776 was used in Flow cytometry/Cell sorting to investigate the effects of costimulating surface proteins CD28 and ICAM-1 on naive T cell differentiation.
Fri Dec 02 00:00:00 EST 2011
Separation of human CD4+CD39+ T cells by magnetic beads reveals two phenotypically and functionally different subsets.
Journal of immunological methods
Schuler PJ,Harasymczuk M,Schilling B,Lang S,Whiteside TL
12-4776 was used in Flow cytometry/Cell sorting to investigate how CD4(+)CD39(+) Treg capture on immunobeads led to a discovery of two CD39(+) subsets.
Thu Jun 30 00:00:00 EDT 2011
Hypoxia potentiates glioma-mediated immunosuppression.
PloS one
Wei J,Wu A,Kong LY,Wang Y,Fuller G,Fokt I,Melillo G,Priebe W,Heimberger AB
12-4776 was used in Flow cytometry/Cell sorting to compare the immunosuppressive properties of glioblastoma multiforme associated cancer stem cells under normoxic and hypoxic conditions, showing that hypoxia potentiated inhibition of T cell activity and macrophage phagocytosis, mediated by STAT3, HIF-1α and VEGF.
Thu Jan 20 00:00:00 EST 2011
miR-155, a Modulator of FOXO3a Protein Expression, Is Underexpressed and Cannot Be Upregulated by Stimulation of HOZOT, a Line of Multifunctional Treg.
PloS one
Yamamoto M,Kondo E,Takeuchi M,Harashima A,Otani T,Tsuji-Takayama K,Yamasaki F,Kumon H,Kibata M,Nakamura S
12-4776 was used in Flow cytometry/Cell sorting to study the expression of miR-155 in CD4(+)CD8(+) HOZOT regulatory T cells, as well as in conventional T cells.
Thu Feb 03 00:00:00 EST 2011
Frequency of circulating regulatory T cells increases during chronic HIV infection and is largely controlled by highly active antiretroviral therapy.
PloS one
Presicce P,Orsborn K,King E,Pratt J,Fichtenbaum CJ,Chougnet CA
12-4776 was used in Flow cytometry/Cell sorting to analyse Treg frequency and phenotype in 11 HIV-infected individuals enrolled in a single, prospective clinical trial.
Fri Jul 20 00:00:00 EDT 2012
In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia.
Blood
Choi J,Ritchey J,Prior JL,Holt M,Shannon WD,Deych E,Piwnica-Worms DR,DiPersio JF
12-4776 was used in Flow cytometry/Cell sorting to demonstrate that hypomethylating agents, decitabine and azacitidine, induce FOXP3 expression in CD4(+)CD25(-) T cells both in vitro and in vivo.
Thu Jul 08 00:00:00 EDT 2010
Photodepletion differentially affects CD4+ Tregs versus CD4+ effector T cells from patients with chronic graft-versus-host disease.
Blood
Bastien JP,Krosl G,Therien C,Rashkovan M,Scotto C,Cohen S,Allan DS,Hogge D,Egeler RM,Perreault C,Roy DC
12-4776 was used in Flow cytometry/Cell sorting to identify Tregs P-glycoprotein-mediated IL-10 secretion mechanism as central to T cell selection via photodepletion using dibromorhodamine.
Thu Dec 02 00:00:00 EST 2010
T cells expressing constitutively active Akt resist multiple tumor-associated inhibitory mechanisms.
Molecular therapy : the journal of the American Society of Gene Therapy
Sun J,Dotti G,Huye LE,Foster AE,Savoldo B,Gramatges MM,Spencer DM,Rooney CM
12-4776 was used in Flow cytometry/Cell sorting to study how caAkt-transduced T cells showed resistance to several evasion strategies employed by tumors.
Mon Nov 01 00:00:00 EDT 2010
Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1.
PLoS biology
Amarnath S,Costanzo CM,Mariotti J,Ullman JL,Telford WG,Kapoor V,Riley JL,Levine BL,June CH,Fong T,Warner NL,Fowler DH
12-4776 was used in Flow cytometry/Cell sorting to demonstrate that human regulatory T cells can promote immune suppression via dendritic cell modulation through programmed death ligand-1 up-regulation.
Tue Feb 02 00:00:00 EST 2010
Peroxisome proliferator-activated receptor α and γ agonists together with TGF-β convert human CD4+CD25- T cells into functional Foxp3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Lei J,Hasegawa H,Matsumoto T,Yasukawa M
12-4776 was used in Flow cytometry/Cell sorting to study the mechanisms by which peroxisome proliferator-activated receptor α and γ agonists, together with TGF-Β, convert CD4+CD25- T cells into functional Foxp3+ regulatory T cells.
Wed Dec 15 00:00:00 EST 2010
Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.
Journal of immunology (Baltimore, Md. : 1950)
Oo YH,Weston CJ,Lalor PF,Curbishley SM,Withers DR,Reynolds GM,Shetty S,Harki J,Shaw JC,Eksteen B,Hubscher SG,Walker LS,Adams DH
12-4776 was used in Flow cytometry/Cell sorting to investigate the molecular control of Treg recruitment into inflamed human tissue.
Mon Mar 15 00:00:00 EDT 2010
Differential but direct abolishment of human regulatory T cell suppressive capacity by various TLR2 ligands.
Journal of immunology (Baltimore, Md. : 1950)
Oberg HH,Ly TT,Ussat S,Meyer T,Kabelitz D,Wesch D
12-4776 was used in Flow cytometry/Cell sorting to investigate whether TLR2 ligands can abolish human regulatory T cell suppressive capacity.
Sat May 01 00:00:00 EDT 2010
FOXP3+ regulatory T cells and T helper 1, T helper 2, and T helper 17 cells in human early pregnancy decidua.
Biology of reproduction
Mjösberg J,Berg G,Jenmalm MC,Ernerudh J
12-4776 was used in Flow cytometry/Cell sorting to study the chemokine receptor expression profiles in human pregnancy decidua to monitor levels of TH1, TH2, TH17 and Treg cells.
Thu Apr 01 00:00:00 EDT 2010
PGE(2) contributes to TGF-beta induced T regulatory cell function in human non-small cell lung cancer.
American journal of translational research
Baratelli F,Lee JM,Hazra S,Lin Y,Walser TC,Schaue D,Pak PS,Elashoff D,Reckamp K,Zhang L,Fishbein MC,Sharma S,Dubinett SM
12-4776 was used in Flow cytometry/Cell sorting to observe the interplay between TGF-beta and prostaglandin E2 in the induction of CD4(+)CD25(bright) regulatory T cells.
Wed Jun 30 00:00:00 EDT 2010
Effects of nilotinib on regulatory T cells: the dose matters.
Molecular cancer
Fei F,Yu Y,Schmitt A,Rojewski MT,Chen B,Greiner J,Götz M,Bunjes D,Schmitt M
12-4776 was used in Flow cytometry/Cell sorting to measure the expression of the transcription factor forkhead box P3 and the glucocorticoid-induced tumor necrosis factor receptor in Tregs.
Fri Jan 29 00:00:00 EST 2010
Naturally occurring regulatory T cells show reduced sensitivity toward oxidative stress-induced cell death.
Blood
Mougiakakos D,Johansson CC,Kiessling R
12-4776 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying elevated numbers of Tregs in hematologic and solid malignancies.
Thu Apr 09 00:00:00 EDT 2009
Intratumoral immune cell infiltrates, FoxP3, and indoleamine 2,3-dioxygenase in patients with melanoma undergoing CTLA4 blockade.
Clinical cancer research : an official journal of the American Association for Cancer Research
Ribas A,Comin-Anduix B,Economou JS,Donahue TR,de la Rocha P,Morris LF,Jalil J,Dissette VB,Shintaku IP,Glaspy JA,Gomez-Navarro J,Cochran AJ
12-4776 was used in Flow cytometry/Cell sorting to show that tumor regression after administration of a CTLA4-blocking antibody to patients with metastatic melanoma is accompanied by a dense tumor infiltration by CD8+ CTL.
Thu Jan 01 00:00:00 EST 2009
The role of the CD58 locus in multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America
De Jager PL,Baecher-Allan C,Maier LM,Arthur AT,Ottoboni L,Barcellos L,McCauley JL,Sawcer S,Goris A,Saarela J,Yelensky R,Price A,Leppa V,Patterson N,de Bakker PI,Tran D,Aubin C,Pobywajlo S,Rossin E,Hu X,Ashley CW,Choy E,Rioux JD,Pericak-Vance MA,Ivinson A,Booth DR,Stewart GJ,Palotie A,Peltonen L,Dubois B,Haines JL,Weiner HL,Compston A,Hauser SL,Daly MJ,Reich D,Oksenberg JR,Hafler DA
12-4776 was used in Flow cytometry/Cell sorting to study the role of the CD58 locus in multiple sclerosis.
Tue Mar 31 00:00:00 EDT 2009
Immune mediated autologous cytotoxicity against hematopoietic precursor cells in patients with myelodysplastic syndrome.
Haematologica
Chamuleau ME,Westers TM,van Dreunen L,Groenland J,Zevenbergen A,Eeltink CM,Ossenkoppele GJ,van de Loosdrecht AA
12-4776 was used in Flow cytometry/Cell sorting to identify a role for active immune-surveillance in myelodysplastic syndrome, as demonstrated by activated T cells and TCR-Vss skewing.
Wed Apr 01 00:00:00 EDT 2009
Distinct roles for FOXP3 and FOXP3 CD4 T cells in regulating cellular immunity to uncomplicated and severe Plasmodium falciparum malaria.
PLoS pathogens
Walther M,Jeffries D,Finney OC,Njie M,Ebonyi A,Deininger S,Lawrence E,Ngwa-Amambua A,Jayasooriya S,Cheeseman IH,Gomez-Escobar N,Okebe J,Conway DJ,Riley EM
12-4776 was used in Flow cytometry/Cell sorting to suggest that despite Tregs not actually regulating inflammation in acute malaria, they might limit memory responses to levels that subsequently allow parasite clearance without immunopathology.
Wed Apr 01 00:00:00 EDT 2009
Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation.
European journal of immunology
Hoffmann P,Boeld TJ,Eder R,Huehn J,Floess S,Wieczorek G,Olek S,Dietmaier W,Andreesen R,Edinger M
12-4776 was used in Flow cytometry/Cell sorting to study the epigenetic regulation of the FOXP3 gene locus in regulatory T cells following repetitive in vitro stimulation.
Wed Apr 01 00:00:00 EDT 2009
Unique phenotype of human tonsillar and in vitro-induced FOXP3+CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Siegmund K,Rückert B,Ouaked N,Bürgler S,Speiser A,Akdis CA,Schmidt-Weber CB
12-4776 was used in Flow cytometry/Cell sorting to investigate whether FOXP3 also acts as a Treg master switch in peripheral blood and tonsillar CD8(+) T cells.
Sun Feb 15 00:00:00 EST 2009
Regulatory T cell (Treg) subsets return in patients with refractory lupus following stem cell transplantation, and TGF-beta-producing CD8+ Treg cells are associated with immunological remission of lupus.
Journal of immunology (Baltimore, Md. : 1950)
Zhang L,Bertucci AM,Ramsey-Goldman R,Burt RK,Datta SK
12-4776 was used in Flow cytometry/Cell sorting to show that after hemopoietic stem cell posttransplant patients certain Treg populations return to levels seen in healthy patient.
Sun Nov 15 00:00:00 EST 2009
Determinants of in vitro expansion of different human virus-specific FoxP3+ regulatory CD8+ T cells in chronic hepatitis C virus infection.
The Journal of general virology
Billerbeck E,Nakamoto N,Seigel B,Blum HE,Chang KM,Thimme R
12-4776 was used in Flow cytometry/Cell sorting to suggest that the ability to expand FoxP3+ regulatory CD8+ T cells from virus-specific CD8+ T cells depends on differentiation status.
Wed Jul 01 00:00:00 EDT 2009
The importance of Foxp3 antibody and fixation/permeabilization buffer combinations in identifying CD4+CD25+Foxp3+ regulatory T cells.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Law JP,Hirschkorn DF,Owen RE,Biswas HH,Norris PJ,Lanteri MC
12-4776 was used in Flow cytometry/Cell sorting to develop a multiparameter flow cytometric panel with Foxp3 for optimal identification of Tregs.
Tue Dec 01 00:00:00 EST 2009
Fludarabine modulates immune response and extends in vivo survival of adoptively transferred CD8 T cells in patients with metastatic melanoma.
PloS one
Wallen H,Thompson JA,Reilly JZ,Rodmyre RM,Cao J,Yee C
12-4776-42 was used in Immunocytochemistry to evaluate the use of fludarabine as a conditioning regimen capable of promoting T cell persistence following adoptive transfer.
Thu May 14 00:00:00 EDT 2009
CD13+CD4+CD25hi regulatory T cells exhibit higher suppressive function and increase with tumor stage in non-small cell lung cancer patients.
Cell cycle (Georgetown, Tex.)
Ju S,Qiu H,Zhou X,Zhu B,Lv X,Huang X,Li J,Zhang Y,Liu L,Ge Y,Johnson DE,Ju S,Shu Y
12-4776 was used in Flow cytometry/Cell sorting to study a subpopulation of CD4+CD25hiTreg cells in the peripheral blood of non-small cell lung cancer patients.
Sat Aug 15 00:00:00 EDT 2009
IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes.
Blood
Li Y,Yee C
12-4776 was used in Flow cytometry/Cell sorting to demonstrate that regulatory T-cell depletion can lead to substantially enhanced generation of tumour-associated antigen-specific cytotoxic T lymphocytes.
Tue Jan 01 00:00:00 EST 2008
Reciprocal CD4+ T-cell balance of effector CD62Llow CD4+ and CD62LhighCD25+ CD4+ regulatory T cells in small cell lung cancer reflects disease stage.
Clinical cancer research : an official journal of the American Association for Cancer Research
Koyama K,Kagamu H,Miura S,Hiura T,Miyabayashi T,Itoh R,Kuriyama H,Tanaka H,Tanaka J,Yoshizawa H,Nakata K,Gejyo F
12-4776 was used in Flow cytometry/Cell sorting to elucidate the immunologic balance induced in small cell lung cancer patients, showing that reciprocal CD4+ T-cell balance of effector and Tregs reflects disease stage.
Sat Nov 01 00:00:00 EDT 2008
Expression of the Epstein-Barr virus-encoded Epstein-Barr virus nuclear antigen 1 in Hodgkin's lymphoma cells mediates Up-regulation of CCL20 and the migration of regulatory T cells.
The American journal of pathology
Baumforth KR,Birgersdotter A,Reynolds GM,Wei W,Kapatai G,Flavell JR,Kalk E,Piper K,Lee S,Machado L,Hadley K,Sundblad A,Sjoberg J,Bjorkholm M,Porwit AA,Yap LF,Teo S,Grundy RG,Young LS,Ernberg I,Woodman CB,Murray PG
12-4776 was used in Flow cytometry/Cell sorting to identify a mechanism by which EBV can recruit Tregs to the microenvironment of HL by inducing the expression of CCL20.
Tue Jul 01 00:00:00 EDT 2008
Expression and function of PDCD1 at the human maternal-fetal interface.
Biology of reproduction
Taglauer ES,Trikhacheva AS,Slusser JG,Petroff MG
12-4776 was used in Flow cytometry/Cell sorting to examine whether human maternal T cells express PDCD1.
Mon Sep 01 00:00:00 EDT 2008
Comparative study of regulatory T cell function of human CD25CD4 T cells from thymocytes, cord blood, and adult peripheral blood.
Clinical & developmental immunology
Fujimaki W,Takahashi N,Ohnuma K,Nagatsu M,Kurosawa H,Yoshida S,Dang NH,Uchiyama T,Morimoto C
12-4776 was used in Flow cytometry/Cell sorting to investigate the functional differences of CD25(+)CD4(+) T cells from thymocytes, cord blood (CB), and adult peripheral blood (APB).
Fri Jan 02 00:00:00 EST 2009
Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells.
Blood
Crellin NK,Garcia RV,Levings MK
12-4776 was used in Flow cytometry/Cell sorting to demonstrate a causal association between altered signalling and the function of CD4+CD25+ Treg cells.
Thu Mar 01 00:00:00 EST 2007
Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype.
Blood
Tran DQ,Ramsey H,Shevach EM
12-4776 was used in Flow cytometry/Cell sorting to suggest that high levels of FOXP3 expression are insufficient to define a human CD4+ T cell as a T-regulatory cell.
Mon Oct 15 00:00:00 EDT 2007
Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta.
The Journal of experimental medicine
Nadkarni S,Mauri C,Ehrenstein MR
12-4776 was used in Flow cytometry/Cell sorting to study how infliximab therapy induces Treg cells and restores tolerance in autoimmune diseases.
Mon Jan 22 00:00:00 EST 2007
GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells.
PLoS biology
Mantel PY,Kuipers H,Boyman O,Rhyner C,Ouaked N,Rückert B,Karagiannidis C,Lambrecht BN,Hendriks RW,Crameri R,Akdis CA,Blaser K,Schmidt-Weber CB
12-4776 was used in Flow cytometry/Cell sorting to describe a mechanism controlling inducible Treg polarisation, which is overruled by the Th2 differentiation pathway involving IL-4 and GATA3.
Sat Dec 01 00:00:00 EST 2007
Endogenous TGF-beta activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25- T cells.
Retrovirology
Amarnath S,Dong L,Li J,Wu Y,Chen W
12-4776 was used in Flow cytometry/Cell sorting to investigate the possible role of TGF-β in the induction of human Tregs by TCR engagement.
Thu Aug 09 00:00:00 EDT 2007
Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion.
Blood
Hoffmann P,Eder R,Boeld TJ,Doser K,Piseshka B,Andreesen R,Edinger M
12-4776 was used in Flow cytometry/Cell sorting to suggest that isolation and expansion of CD45RA+ naive CD4+ CD25high T cells is ideal for adoptive regulatory T (Treg)-cell therapies.
Fri Dec 15 00:00:00 EST 2006
Transient accumulation of human mature thymocytes and regulatory T cells with CD28 superagonist in "human immune system" Rag2(-/-)gammac(-/-) mice.
Blood
Legrand N,Cupedo T,van Lent AU,Ebeli MJ,Weijer K,Hanke T,Spits H
12-4776 was used in Flow cytometry/Cell sorting to show that superagonist anti-CD28 treatment transiently induces a 7-fold increase in thymocytes and up to 18-fold accumulation of mature thymocytes.
Sat Jul 01 00:00:00 EDT 2006
IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo.
Blood
Zorn E,Nelson EA,Mohseni M,Porcheray F,Kim H,Litsa D,Bellucci R,Raderschall E,Canning C,Soiffer RJ,Frank DA,Ritz J
12-4776 was used in Flow cytometry/Cell sorting to examine the effects of IL-2 signalling in human regulatory T cells.
Fri Sep 01 00:00:00 EDT 2006
Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART.
Blood
Epple HJ,Loddenkemper C,Kunkel D,Tröger H,Maul J,Moos V,Berg E,Ullrich R,Schulzke JD,Stein H,Duchmann R,Zeitz M,Schneider T
Wed Nov 01 00:00:00 EST 2006
Isolation of CD4+CD25+ regulatory T cells for clinical trials.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Hoffmann P,Boeld TJ,Eder R,Albrecht J,Doser K,Piseshka B,Dada A,Niemand C,Assenmacher M,Orsó E,Andreesen R,Holler E,Edinger M
12-4776 was used in Flow cytometry/Cell sorting to describe the isolation of CD4+CD25+ T cells with regulatory function from standard leukapheresis products by using a 2-step magnetic cell-separation protocol performed under GMP conditions.
Wed Mar 01 00:00:00 EST 2006
Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Lim HW,Hillsamer P,Banham AH,Kim CH
Sat Oct 01 00:00:00 EDT 2005
