Product References
Low-density lipoprotein balances T cell metabolism and enhances response to anti-PD-1 blockade in a HCT116 spheroid model.
Frontiers in oncology
Babl N,Hofbauer J,Matos C,Voll F,Menevse AN,Rechenmacher M,Mair R,Beckhove P,Herr W,Siska PJ,Renner K,Kreutz M,Schnell A
17-4776-42 was used in Flow cytometry/Cell sorting to investigate the effect of LDL on T cell activation and tumor immunity in-vitro.
Tue Feb 14 00:00:00 EST 2023
Noninvasive Imaging of CD4+ T Cells in Humanized Mice.
Molecular cancer therapeutics
Nagle VL,Hertz CAJ,Henry KE,Graham MS,Campos C,Pillarsetty N,Schietinger A,Mellinghoff IK,Lewis JS
17-4776-42 was used in Flow cytometry/Cell sorting to explore immunoPET using an anti-human-CD4 minibody.
Fri Apr 01 00:00:00 EDT 2022
Level of interleukin-35 in patients with idiopathic membranous nephropathy and its predictive value for remission time.
Frontiers in immunology
Zhang N,Dai H,Dong X,Liu W,Jiang H,Zhao Q,Gao Y,Feng Z,Dong Z,Hu Y,Huang G,Rui H,Liu B
17-4776-42 was used in Flow cytometry/Cell sorting to clarify the relationship between IL-35 and disease activity and remission of idiopathic membranous nephropathy.
Mon Aug 22 00:00:00 EDT 2022
Chronic morphine administration differentially modulates viral reservoirs in SIVmac251 infected rhesus macaque model.
Journal of virology
Acharya A,Olwenyi OA,Thurman M,Pandey K,Morsey BM,Lamberty B,Ferguson N,Callen S,Fang Q,Buch SJ,Fox HS,Byrareddy SN
17-4776-42 was used in Flow Cytometry to suggest that people with HIV who abuse opioids had higher reservoirs in CNS than the lymphoid system.
Mon Mar 01 00:00:00 EST 2021
Soluble fibrinogen‑like protein 2 levels are decreased in patients with ischemic heart failure and associated with cardiac function.
Molecular medicine reports
You Y,Huang S,Liu H,Fan C,Liu K,Wang Z
17-4776-42 was used in Flow Cytometry to determine serum soluble fibrinogen‚like protein 2 levels in patients with ischemic heart failure.
Sun Aug 01 00:00:00 EDT 2021
Different Background: Natural Killer Cell Profiles in Secondary versus Primary Recurrent Pregnancy Loss.
Journal of clinical medicine
Strobel L,Vomstein K,Kyvelidou C,Hofer-Tollinger S,Feil K,Kuon RJ,Ebner S,Troppmair J,Toth B
17-4776 was used in Flow cytometry/Cell sorting to suggest a chronic immune stimulation leading to a lower natural killer cell count in secondary recurrent pregnancy loss patients with a lower natural killer cytotoxicity.
Thu Jan 07 00:00:00 EST 2021
Protein/AS01B vaccination elicits stronger, more Th2-skewed antigen-specific human T follicular helper cell responses than heterologous viral vectors.
Cell reports. Medicine
Nielsen CM,Ogbe A,Pedroza-Pacheco I,Doeleman SE,Chen Y,Silk SE,Barrett JR,Elias SC,Miura K,Diouf A,Bardelli M,Dabbs RA,Barfod L,Long CA,Haynes BF,Payne RO,Minassian AM,Bradley T,Draper SJ,Borrow P
17-4776-42 was used in Flow Cytometry to highlight the impact of vaccine platform on the cTfh cell response driving humoral immunity, associating a high-magnitude, Th2-biased cTfh response with potent antibody production.
Tue Mar 16 00:00:00 EDT 2021
Engineering of a trispecific tumor-targeted immunotherapy incorporating 4-1BB co-stimulation and PD-L1 blockade.
Oncoimmunology
Warmuth S,Gunde T,Snell D,Brock M,Weinert C,Simonin A,Hess C,Tietz J,Johansson M,Spiga FM,Heiz R,Flückiger N,Wagen S,Zeberer J,Diem D,Mahler D,Wickihalder B,Muntwiler S,Chatterjee B,Küttner B,Bommer B,Yaman Y,Lichtlen P,Urech D
17-4776-42 was used in Flow cytometry/Cell sorting to engineer a tri-specific antibody-based molecule that stimulates intratumoral 4-1BB and blocks PD-L1/PD-1 signaling without systemic toxicity and with clinically favorable pharmacokinetics.
Tue Jul 19 00:00:00 EDT 2022
A controlled human Schistosoma mansoni infection model to advance novel drugs, vaccines and diagnostics.
Nature medicine
Langenberg MCC,Hoogerwerf MA,Koopman JPR,Janse JJ,Kos-van Oosterhoud J,Feijt C,Jochems SP,de Dood CJ,van Schuijlenburg R,Ozir-Fazalalikhan A,Manurung MD,Sartono E,van der Beek MT,Winkel BMF,Verbeek-Menken PH,Stam KA,van Leeuwen FWB,Meij P,van Diepen A,van Lieshout L,van Dam GJ,Corstjens PLAM,Hokke CH,Yazdanbakhsh M,Visser LG,Roestenberg M
17-4776 was used in Flow cytometry/Cell sorting to performed a dose-escalating clinical safety trial in 17 volunteers with male Schistosoma mansoni cercariae, which do not produce eggs (clinicaltrials.gov NCT02755324), at the Leiden University Medical Center, the Netherlands.
Sun Mar 01 00:00:00 EST 2020
Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense.
Cell
Lai NY,Musser MA,Pinho-Ribeiro FA,Baral P,Jacobson A,Ma P,Potts DE,Chen Z,Paik D,Soualhi S,Yan Y,Misra A,Goldstein K,Lagomarsino VN,Nordstrom A,Sivanathan KN,Wallrapp A,Kuchroo VK,Nowarski R,Starnbach MN,Shi H,Surana NK,An D,Wu C,Huh JR,Rao M,Chiu IM
17-4776-42 was used in Flow Cytometry to reveal a major role for nociceptor neurons in sensing and defending against enteric pathogens.
Thu Jan 09 00:00:00 EST 2020
Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity.
Immunity
Turner JA,Stephen-Victor E,Wang S,Rivas MN,Abdel-Gadir A,Harb H,Cui Y,Fanny M,Charbonnier LM,Fong JJH,Benamar M,Wang L,Burton OT,Bansal K,Bry L,Zhu C,Li QZ,Clement RL,Oettgen HC,Crestani E,Rachid R,Sage PT,Chatila TA
17-4776-42 was used in Flow Cytometry to show that Treg cells in food allergy (FA) had decreased expression of transforming growth factor beta 1 (TGF-β1) because of interleukin-4 (IL-4)- and signal transducer and activator of transciription-6 (STAT6)-dependent inhibition of Tgfb1 transcription.
Tue Dec 15 00:00:00 EST 2020
Aberrant Th2 Immune Responses Are Associated With a Reduced Frequency of IL-35-Induced Regulatory T Cells After Allergen Exposure in Patients With Allergic Asthma.
Allergy, asthma & immunology research
Wang W,Wei C,Cheng Z,Yang J
17-4776 was used in Flow cytometry/Cell sorting to investigate whether Interleukin (IL)-35-induced regulatory T cells involve in the immunoregulation of allergic asthmatic individuals after specific allergen exposure.
Sun Nov 01 00:00:00 EDT 2020
Glutamic Acid Decarboxylase Injection Into Lymph Nodes: Beta Cell Function and Immune Responses in Recent Onset Type 1 Diabetes Patients.
Frontiers in immunology
Casas R,Dietrich F,Barcenilla H,Tavira B,Wahlberg J,Achenbach P,Ludvigsson J
17-4776-42 was used in Flow Cytometry to improve efficacy of GAD-alum treatment using lymph-node administration in combination with oral vitamin D.
Mon May 03 00:00:00 EDT 2021
Obesity and Sex Affect the Immune Responses to Tick-Borne Encephalitis Booster Vaccination.
Frontiers in immunology
Garner-Spitzer E,Poellabauer EM,Wagner A,Guzek A,Zwazl I,Seidl-Friedrich C,Binder CJ,Stiasny K,Kundi M,Wiedermann U
17-4776-42 was used in Flow Cytometry to assess the responsiveness to tick-borne encephalitis vaccine, evaluating metabolic, hormonal, and immunologic profiles along with vaccine-specific humoral and cellular immune responses.
Mon Apr 05 00:00:00 EDT 2021
Neonatal Rhesus Macaques Have Distinct Immune Cell Transcriptional Profiles following HIV Envelope Immunization.
Cell reports
Han Q,Bradley T,Williams WB,Cain DW,Montefiori DC,Saunders KO,Parks RJ,Edwards RW,Ferrari G,Mueller O,Shen X,Wiehe KJ,Reed S,Fox CB,Rountree W,Vandergrift NA,Wang Y,Sutherland LL,Santra S,Moody MA,Permar SR,Tomaras GD,Lewis MG,Van Rompay KKA,Haynes BF
17-4776 was used in Flow cytometry/Cell sorting to compare the ability of neonatal and adult macaque immune systems to respond to these HIV-1 envelope immunogen forms through the immunisation of neonatal and adult macaques with HIV-1 CH505 gp120 or SOSIP trimer immunogens.
Tue Feb 04 00:00:00 EST 2020
Chromatin Landscape Underpinning Human Dendritic Cell Heterogeneity.
Cell reports
Leylek R,Alcántara-Hernández M,Granja JM,Chavez M,Perez K,Diaz OR,Li R,Satpathy AT,Chang HY,Idoyaga J
17-4776 was used in Flow cytometry/Cell sorting to investigate analyze global chromatin accessibility profiles across resting and stimulated human DC subsets by means of the assay for transposase-accessible chromatin using sequencing (ATAC-seq).
Tue Sep 22 00:00:00 EDT 2020
Profound Treg perturbations correlate with COVID-19 severity.
bioRxiv : the preprint server for biology
Galvan-Pena S,Leon J,Chowdhary K,Michelson DA,Vijaykumar B,Yang L,Magnuson A,Manickas-Hill Z,Piechocka-Trocha A,Worrall DP,Hall KE,Ghebremichael M,Walker BD,Li JZ,Yu XG,Mathis D,Benoist C
17-4776-42 was used in Flow Cytometry to suggest that Tregs may play nefarious roles in COVID-19, via suppressing anti-viral T cell responses during the severe phase of the disease, and/or via a direct pro-inflammatory role.
Tue Dec 15 00:00:00 EST 2020
IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis.
Journal of immunology (Baltimore, Md. : 1950)
Lindahl H,Guerreiro-Cacais AO,Bedri SK,Linnerbauer M,Lindén M,Abdelmagid N,Tandre K,Hollins C,Irving L,Glover C,Jones C,Alfredsson L,Rönnblom L,Kockum I,Khademi M,Jagodic M,Olsson T
17-4776-42 was used in Flow Cytometry to study the genetic risk variant rs17066096 and the candidate gene that encodes IL-22 binding protein (IL-22BP).
Thu Aug 15 00:00:00 EDT 2019
Umbilical cord blood‑derived Helios‑positive regulatory T cells promote angiogenesis in acute lymphoblastic leukemia in mice via CCL22 and the VEGFA‑VEGFR2 pathway.
Molecular medicine reports
Li X,Li D,Shi Q,Huang X,Ju X
17-4776 was used in Flow cytometry/Cell sorting to elucidate the mechanisms underlying the role of regulatory T cells in acute lymphoblastic leukaemia.
Wed May 01 00:00:00 EDT 2019
Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO mice.
Life science alliance
Matsuda M,Ono R,Iyoda T,Endo T,Iwasaki M,Tomizawa-Murasawa M,Saito Y,Kaneko A,Shimizu K,Yamada D,Ogonuki N,Watanabe T,Nakayama M,Koseki Y,Kezuka-Shiotani F,Hasegawa T,Yabe H,Kato S,Ogura A,Shultz LD,Ohara O,Taniguchi M,Koseki H,Fujii SI,Ishikawa F
17-4776 was used in Flow cytometry/Cell sorting to create NOD/SCID/IL2rgKO (NSG) mice expressing hIL-7 and hIL-15 to reduce the species barrier in human immunity studies.
Mon Apr 01 00:00:00 EDT 2019
Transient increase of activated regulatory T cells early after kidney transplantation.
Scientific reports
Mederacke YS,Vondran FW,Kollrich S,Schulde E,Schmitt R,Manns MP,Klempnauer J,Schwinzer R,Noyan F,Jaeckel E
17-4776 was used in Flow cytometry/Cell sorting to demonstrate that total CD4+CD25highFOXP3+ Treg numbers decreased in the first three months after kidney transplantation, while frequency of activated Tregs increased significantly.
Thu Jan 31 00:00:00 EST 2019
The Translational Machinery of Human CD4+ T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling.
Cell metabolism
Ricciardi S,Manfrini N,Alfieri R,Calamita P,Crosti MC,Gallo S,Müller R,Pagani M,Abrignani S,Biffo S
17-4776 was used in Flow cytometry/Cell sorting to discover that T cells fulfill this transitional process through translational control.
Tue Dec 04 00:00:00 EST 2018
Humoral immune response to adenovirus induce tolerogenic bystander dendritic cells that promote generation of regulatory T cells.
PLoS pathogens
Tran TTP,Eichholz K,Amelio P,Moyer C,Nemerow GR,Perreau M,Mennechet FJD,Kremer EJ
17-4776 was used in Flow cytometry/Cell sorting to identify a mechanism by which an antiviral humoural response could, counterintuitively, favour virus persistence.
Wed Aug 01 00:00:00 EDT 2018
Intralymphatic Glutamic Acid Decarboxylase-Alum Administration Induced Th2-Like-Specific Immunomodulation in Responder Patients: A Pilot Clinical Trial in Type 1 Diabetes.
Journal of diabetes research
Tavira B,Barcenilla H,Wahlberg J,Achenbach P,Ludvigsson J,Casas R
17-4776 was used in Flow cytometry/Cell sorting to compare the immunomodulatory effect of giving GAD-alum directly into lymph nodes versus that induced by subcutaneous administration.
Tue Dec 11 00:00:00 EST 2018
Neonatal neutrophils stimulated by group B Streptococcus induce a proinflammatory T-helper cell bias.
Pediatric research
Lin J,Haridas S,Barenkamp SJ,Lorenset LC,Lee ASE,Schroeder BT,Peng G,Koenig JM
17-4776 was used in Flow cytometry/Cell sorting to study the mechanisms underlying Group B Streptococcus inflammation.
Thu Mar 01 00:00:00 EST 2018
CD39+ regulatory T cells accumulate in colon adenocarcinomas and display markers of increased suppressive function.
Oncotarget
Ahlmanner F,Sundström P,Akeus P,Eklöf J,Börjesson L,Gustavsson B,Lindskog EB,Raghavan S,Quiding-Järbrink M
17-4776 was used in Flow cytometry/Cell sorting to treg therapy may hamper development of long-term tolerance and should be approached with caution in the clinical autologous setting.
Tue Dec 11 00:00:00 EST 2018
Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis.
Nature communications
Sun M,Wu W,Chen L,Yang W,Huang X,Ma C,Chen F,Xiao Y,Zhao Y,Ma C,Yao S,Carpio VH,Dann SM,Zhao Q,Liu Z,Cong Y
17-4776-42 was used in Flow Cytometry to elucidate the various roles of gut microbiota-derived short-chain fatty acids in the maintenance of intestinal homeostasis.
Mon Sep 03 00:00:00 EDT 2018
Long-term Survival in Glioblastoma with Cytomegalovirus pp65-Targeted Vaccination.
Clinical cancer research : an official journal of the American Association for Cancer Research
Batich KA,Reap EA,Archer GE,Sanchez-Perez L,Nair SK,Schmittling RJ,Norberg P,Xie W,Herndon JE,Healy P,McLendon RE,Friedman AH,Friedman HS,Bigner D,Vlahovic G,Mitchell DA,Sampson JH
17-4776 was used in Flow cytometry/Cell sorting to evaluate pp65-specific cellular responses following DI-TMZ with pp65-DCs and determined the effects on long-term progression-free survival (PFS) and overall survival (OS).
Sat Apr 15 00:00:00 EDT 2017
B and T Cell Phenotypic Profiles of African HIV-Infected and HIV-Exposed Uninfected Infants: Associations with Antibody Responses to the Pentavalent Rotavirus Vaccine.
Frontiers in immunology
Weinberg A,Lindsey J,Bosch R,Persaud D,Sato P,Ogwu A,Asmelash A,Bwakura-Dangarambezi M,Chi BH,Canniff J,Lockman S,Gaseitsiwe S,Moyo S,Smith CE,Moraka NO,Levin MJ
17-4776 was used in Flow cytometry/Cell sorting to examined associations between B and T cell phenotypic profiles and antibody responses to the pentavalent rotavirus vaccine in perinatally HIV-infected infants.
Tue Apr 07 00:00:00 EDT 2020
Follicular Regulatory T Cells Are Highly Permissive to R5-Tropic HIV-1.
Journal of virology
Miller SM,Miles B,Guo K,Folkvord J,Meditz AL,McCarter MD,Levy DN,MaWhinney S,Santiago ML,Connick E
17-4776 was used in Flow cytometry/Cell sorting to show that follicular regulatory T cells are highly permissive to HIV-1 both ex vivo and in vivo.
Fri Sep 01 00:00:00 EDT 2017
Low-dose interleukin-2 promotes STAT-5 phosphorylation, Treg survival and CTLA-4-dependent function in autoimmune liver diseases.
Clinical and experimental immunology
Jeffery HC,Jeffery LE,Lutz P,Corrigan M,Webb GJ,Hirschfield GM,Adams DH,Oo YH
17477642 was used in flow cytometry to examine the potential of IL-2 to enhance T regulatory cell therapy
Thu Jun 01 00:00:00 EDT 2017
Two separate effects contribute to regulatory T cell defect in systemic lupus erythematosus patients and their unaffected relatives.
Clinical and experimental immunology
Costa N,Marques O,Godinho SI,Carvalho C,Leal B,Figueiredo AM,Vasconcelos C,Marinho A,Moraes-Fontes MF,Gomes da Costa A,Ponte C,Campanilho-Marques R,Cóias T,Martins AR,Viana JF,Lima M,Martins B,Fesel C
17-4776 was used in Flow cytometry/Cell sorting to determine the origin and role of the SLE Treg phenotype in systemic lupus erythematosus.
Fri Sep 01 00:00:00 EDT 2017
Tolerogenic dendritic cells generated with dexamethasone and vitamin D3 regulate rheumatoid arthritis CD4+ T cells partly via transforming growth factor-β1.
Clinical and experimental immunology
Anderson AE,Swan DJ,Wong OY,Buck M,Eltherington O,Harry RA,Patterson AM,Pratt AG,Reynolds G,Doran JP,Kirby JA,Isaacs JD,Hilkens CM
Sun Jan 01 00:00:00 EST 2017
Decreased Helios Expression in Regulatory T Cells in Acute Coronary Syndrome.
Disease markers
Jiang L,Chen F,Hu X,Hu Y,Wang Y,Zhang W,Peng Y,Cheng L
17-4776 was used in Flow cytometry/Cell sorting to study the role of Helios in acute coronary syndrome.
Fri Aug 03 00:00:00 EDT 2018
Genetic variation at the CD28 locus and its impact on expansion of pro-inflammatory CD28 negative T cells in healthy individuals.
Scientific reports
Liaskou E,Jeffery L,Chanouzas D,Soskic B,Seldin MF,Harper L,Sansom D,Hirschfield GM
17-4776 was used in Flow cytometry/Cell sorting to assess whether the primary sclerosing cholangitis-associated CD28 risk variant A affects CD28 expression and T cell function in healthy individuals.
Wed Aug 09 00:00:00 EDT 2017
Ex-vivo characterization of regulatory T cells in pulmonary tuberculosis patients, latently infected persons, and healthy endemic controls.
Tuberculosis (Edinburgh, Scotland)
Zewdie M,Howe R,Hoff ST,Doherty TM,Getachew N,Tarekegne A,Tessema B,Yamuah L,Aseffa A,Abebe M
17-4776 was used in Flow cytometry/Cell sorting to show that regulatory T cell subsets may be differentially regulated and expressed in Tuberculosis disease, cure, and infection.
Thu Sep 01 00:00:00 EDT 2016
Tumor-derived exosomes regulate expression of immune function-related genes in human T cell subsets.
Scientific reports
Muller L,Mitsuhashi M,Simms P,Gooding WE,Whiteside TL
17-4776 was used in Flow cytometry/Cell sorting to study the regulation of immune function-related genes in human T cell subsets through tumor-derived exosomes.
Thu Feb 04 00:00:00 EST 2016
PD-L1 mediated the differentiation of tumor-infiltrating CD19+ B lymphocytes and T cells in Invasive breast cancer.
Oncoimmunology
Guan H,Lan Y,Wan Y,Wang Q,Wang C,Xu L,Chen Y,Liu W,Zhang X,Li Y,Gu Y,Wang Z,Xie F
17-4776 was used in Flow cytometry/Cell sorting to investigate the role of B cells in human breast cancer etiology.
Mon Feb 01 00:00:00 EST 2016
Role and species-specific expression of colon T cell homing receptor GPR15 in colitis.
Nature immunology
Nguyen LP,Pan J,Dinh TT,Hadeiba H,O'Hara E,Ebtikar A,Hertweck A,Gökmen MR,Lord GM,Jenner RG,Butcher EC,Habtezion A
17-4776 was used in Flow cytometry/Cell sorting to show that GPR15 can control the colon localization of T effector cells.
Sun Feb 01 00:00:00 EST 2015
Correlation of low CD73 expression on synovial lymphocytes with reduced adenosine generation and higher disease severity in juvenile idiopathic arthritis.
Arthritis & rheumatology (Hoboken, N.J.)
Botta Gordon-Smith S,Ursu S,Eaton S,Moncrieffe H,Wedderburn LR
17-4776 was used in Flow cytometry/Cell sorting to compare the expression of CD73 on lymphocytes from patients with juvenile idiopathic arthritis to healthy control subjects.
Sun Feb 01 00:00:00 EST 2015
Tadalafil reduces myeloid-derived suppressor cells and regulatory T cells and promotes tumor immunity in patients with head and neck squamous cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Weed DT,Vella JL,Reis IM,De la Fuente AC,Gomez C,Sargi Z,Nazarian R,Califano J,Borrello I,Serafini P
17477642 was used in flow cytometry to study the immune effects of tadalafil in patients with head and neck squamous cell carcinoma.
Thu Jan 01 00:00:00 EST 2015
Levels and function of regulatory T cells in patients with polymorphic light eruption: relation to photohardening.
The British journal of dermatology
Schweintzger N,Gruber-Wackernagel A,Reginato E,Bambach I,Quehenberger F,Byrne SN,Wolf P
17-4776 was used in Flow cytometry/Cell sorting to investigate how a UV-induced increase in the number of Tregs may be a mechanism by which the immune system counteracts susceptibility to PLE.
Sat Aug 01 00:00:00 EDT 2015
1,25(OH)2D3 Promotes the Efficacy of CD28 Costimulation Blockade by Abatacept.
Journal of immunology (Baltimore, Md. : 1950)
Gardner DH,Jeffery LE,Soskic B,Briggs Z,Hou TZ,Raza K,Sansom DM
17-4776 was used in Flow cytometry/Cell sorting to investigate how Vitamin D3 supplementation may be a useful adjunct for the treatment of conditions such as rheumatoid arthritis in combination with abatacept to promote the efficacy of treatment.
Tue Sep 15 00:00:00 EDT 2015
Humoral and cellular immune responses after influenza vaccination in patients with postcancer fatigue.
Human vaccines & immunotherapeutics
Prinsen H,van Laarhoven HW,Pots JM,Duiveman-de Boer T,Mulder SF,van Herpen CM,Jacobs JF,Leer JW,Bleijenberg G,Stelma FF,Torensma R,de Vries IJ
17-4776 was used in Flow cytometry/Cell sorting to compare humoral and cellular immune responses to influenza vaccination in cancer survivors with and without severe symptoms of fatigue.
Mon May 09 00:00:00 EDT 2016
CD4+CD25hiFOXP3+ Regulatory T Cells and Cytokine Responses in Human Schistosomiasis before and after Treatment with Praziquantel.
PLoS neglected tropical diseases
Schmiedel Y,Mombo-Ngoma G,Labuda LA,Janse JJ,de Gier B,Adegnika AA,Issifou S,Kremsner PG,Smits HH,Yazdanbakhsh M
17-4776 was used in Flow cytometry/Cell sorting to investigate Treg functional capacity during human Schistosoma haematobium infection.
Sat Aug 01 00:00:00 EDT 2015
Impact of Donation Mode on the Proportion and Function of T Lymphocytes in the Liver.
PloS one
Xystrakis E,Yuksel M,Lin F,Huang X,Pop OT,Quaglia A,Heaton N,Prachalias A,Rela M,Fuggle S,Ma Y,Jassem W
17-4776 was used in Flow cytometry/Cell sorting to compare the properties of T cells in livers obtained from living donors to those obtained from donors after brain or cardiac death.
Wed Jun 15 00:00:00 EDT 2016
Impaired survival of regulatory T cells in pulmonary sarcoidosis.
Respiratory research
Broos CE,van Nimwegen M,Kleinjan A,ten Berge B,Muskens F,in 't Veen JC,Annema JT,Lambrecht BN,Hoogsteden HC,Hendriks RW,Kool M,van den Blink B
17-4776 was used in Flow cytometry/Cell sorting to investigate the role of impaired Treg function in sarcoidosis.
Wed Sep 16 00:00:00 EDT 2015
Characterization of Peripheral Immune Cell Subsets in Patients with Acute and Chronic Cerebrovascular Disease: A Case-Control Study.
International journal of molecular sciences
Kraft P,Drechsler C,Schuhmann MK,Gunreben I,Kleinschnitz C
17-4776 was used in Flow cytometry/Cell sorting to characterise and compare the peripheral immune cell subsets of patients with acute and chronic cerebrovascular disease.
Fri Oct 23 00:00:00 EDT 2015
Blockade of TNF-α signaling benefits cancer therapy by suppressing effector regulatory T cell expansion.
Oncoimmunology
Chang LY,Lin YC,Chiang JM,Mahalingam J,Su SH,Huang CT,Chen WT,Huang CH,Jeng WJ,Chen YC,Lin SM,Sheen IS,Lin CY
17-4776 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms for effector Treg cell expansion in tumours.
Thu Oct 01 00:00:00 EDT 2015
A phase I dose-escalation clinical trial of a peptide-based human papillomavirus therapeutic vaccine with Candida skin test reagent as a novel vaccine adjuvant for treating women with biopsy-proven cervical intraepithelial neoplasia 2/3.
Oncoimmunology
Greenfield WW,Stratton SL,Myrick RS,Vaughn R,Donnalley LM,Coleman HN,Mercado M,Moerman-Herzog AM,Spencer HJ,Andrews-Collins NR,Hitt WC,Low GM,Manning NA,McKelvey SS,Smith D,Smith MV,Phillips AM,Quick CM,Jeffus SK,Hutchins LF,Nakagawa M
17-4776 was used in Flow cytometry/Cell sorting to demonstrate the safety of a human papillomavirus therapeutic vaccine, PepCan.
Thu Oct 01 00:00:00 EDT 2015
Exosomes isolated from plasma of glioma patients enrolled in a vaccination trial reflect antitumor immune activity and might predict survival.
Oncoimmunology
Muller L,Muller-Haegele S,Mitsuhashi M,Gooding W,Okada H,Whiteside TL
17-4776 was used in Flow cytometry/Cell sorting to show exosomes from the plasma of glioma patients from a vaccination trial reflect antitumour immune activity which may predict survival.
Mon Jun 01 00:00:00 EDT 2015
Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production.
PloS one
Lowe MM,Mold JE,Kanwar B,Huang Y,Louie A,Pollastri MP,Wang C,Patel G,Franks DG,Schlezinger J,Sherr DH,Silverstone AE,Hahn ME,McCune JM
17-4776 was used in Flow cytometry/Cell sorting to study the link between tryptophan metabolism and AHR activation and define a novel endogenous AHR agonist with potentially broad biological functions.
Mon Oct 20 00:00:00 EDT 2014
Autologous Graft versus Host Disease: An Emerging Complication in Patients with Multiple Myeloma.
Bone marrow research
Batra A,Cottler-Fox M,Harville T,Rhodes-Clark BS,Makhoul I,Nakagawa M
17-4776 was used in Flow cytometry/Cell sorting to compare expression of cell surface molecules on hematopoietic progenitor cell products between healthy individuals and sufferers of autologous graft versus host disease.
Fri May 30 00:00:00 EDT 2014
Paramyxovirus infection regulates T cell responses by BDCA-1+ and BDCA-3+ myeloid dendritic cells.
PloS one
Gupta MR,Kolli D,Molteni C,Casola A,Garofalo RP
17-4776 was used in Immunocytochemistry to demonstrate a virus-specific and subset specific effect of RSV and hMPV infection on mDC function.
Mon Feb 02 00:00:00 EST 2015
The number of CCR5 expressing CD4+ T lymphocytes is lower in HIV-infected long-term non-progressors with viral control compared to normal progressors: a cross-sectional study.
BMC infectious diseases
Meijerink H,Indrati AR,van Crevel R,Joosten I,Koenen H,van der Ven AJ
17-4776 was used in Immunohistochemistry to determine levels of CCR5 and CXCR4 expression among CD4(+) and CD8(+) lymphocyte subsets in HIV-infected long-term non-progressors.
Sat Dec 13 00:00:00 EST 2014
Plasmodium falciparum induces Foxp3hi CD4 T cells independent of surface PfEMP1 expression via small soluble parasite components.
Frontiers in microbiology
Scholzen A,Cooke BM,Plebanski M
17-4776 was used in Flow cytometry/Cell sorting to suggest that the induction of Foxp3hi T cells by P. falciparum is largely independent of two key immune modulatory parasite components.
Tue May 13 00:00:00 EDT 2014
Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells.
The Journal of clinical investigation
Wang C,Yi T,Qin L,Maldonado RA,von Andrian UH,Kulkarni S,Tellides G,Pober JS
17-4776 was used in Flow cytometry/Cell sorting to show that preoperative conditioning of allograft ECs with rapamycin could potentially reduce immune-mediated rejection.
Mon Apr 01 00:00:00 EDT 2013
Modulation of regulatory T cell function by monocyte-derived dendritic cells matured through electroporation with mRNA encoding CD40 ligand, constitutively active TLR4, and CD70.
Journal of immunology (Baltimore, Md. : 1950)
Pen JJ,De Keersmaecker B,Maenhout SK,Van Nuffel AM,Heirman C,Corthals J,Escors D,Bonehill A,Thielemans K,Breckpot K,Aerts JL
17-4776 was used in Flow cytometry/Cell sorting to investigate the influence of various dendritic cell activation stimuli on regulatory T cell functionality.
Thu Aug 15 00:00:00 EDT 2013
Effect of chronic morphine administration on circulating T cell population dynamics in rhesus macaques.
Journal of neuroimmunology
Cornwell WD,Lewis MG,Fan X,Rappaport J,Rogers TJ
17-4776 was used in Flow cytometry/Cell sorting to give the first detailed report of the impact of chronic morphine administration on circulating T cell dynamics.
Sun Dec 15 00:00:00 EST 2013
Peripheral Th17/Treg imbalance in patients with atherosclerotic cerebral infarction.
International journal of clinical and experimental pathology
Li Q,Wang Y,Yu F,Wang YM,Zhang C,Hu C,Wu Z,Xu X,Hu S
17-4776 was used in Flow cytometry/Cell sorting to study how Th17/Treg cells were imbalanced in ACI patients, and ox-LDL may contribute to this imbalance and lead to the occurrence of ACI.
Mon Dec 23 00:00:00 EST 2013
Increased numbers of circulating CD8 effector memory T cells before transplantation enhance the risk of acute rejection in lung transplant recipients.
PloS one
San Segundo D,Ballesteros MÁ,Naranjo S,Zurbano F,Miñambres E,López-Hoyos M
17-4776 was used in Flow cytometry/Cell sorting to suggest a correlation between acute rejection and effector memory T-cells in lung transplant recipients.
Fri Jul 25 00:00:00 EDT 2014
Changes of cytokines during a spaceflight analog--a 45-day head-down bed rest.
PloS one
Xu X,Tan C,Li P,Zhang S,Pang X,Liu H,Li L,Sun X,Zhang Y,Wu H,Chen X,Ge Q
17-4776 was used in Flow cytometry/Cell sorting to investigate the alterations in human immune cell distributions and their functions in response to various stimuli during head-down bed rest.
Tue Jun 17 00:00:00 EDT 2014
Immune suppression in premalignant respiratory papillomas: enriched functional CD4+Foxp3+ regulatory T cells and PD-1/PD-L1/L2 expression.
Clinical cancer research : an official journal of the American Association for Cancer Research
Hatam LJ,Devoti JA,Rosenthal DW,Lam F,Abramson AL,Steinberg BM,Bonagura VR
17-4776 was used in Flow cytometry/Cell sorting to study how the PD-1/PDL-1 pathway may represent an additional immunosuppressive mechanism that contributes to defective HPV6/11 clearance in RRP.
Sun Apr 01 00:00:00 EDT 2012
Depletion of T regulatory cells through selection of CD127-positive cells results in a population enriched in memory T cells: implications for anti-tumor cell therapy.
Haematologica
Touil S,Rosenzwajg M,Landau DA,Le Corvoisier P,Frédéric C,Klatzmann D,Maury S,Cohen JL
17-4776 was used in Flow cytometry/Cell sorting to show that a strategy of CD127 positive selection is an efficient way of eliminating Treg cells from donor lymphocyte infusions and improves alloreactivity.
Thu Nov 01 00:00:00 EDT 2012
Freeze-thaw lysates of Plasmodium falciparum-infected red blood cells induce differentiation of functionally competent regulatory T cells from memory T cells.
European journal of immunology
Finney OC,Lawrence E,Gray AP,Njie M,Riley EM,Walther M
17-4776 was used in Flow cytometry/Cell sorting to suggest that Plasmodium falciparum schizont extract induces memory T cells to convert into iTreg cells which expand alongside effector T cells.
Sun Jul 01 00:00:00 EDT 2012
Dominant Th2 differentiation of human regulatory T cells upon loss of FOXP3 expression.
Journal of immunology (Baltimore, Md. : 1950)
Hansmann L,Schmidl C,Kett J,Steger L,Andreesen R,Hoffmann P,Rehli M,Edinger M
17-4776 was used in Flow cytometry/Cell sorting to compare the transcriptomes of stable FOXP3(+) Treg and converted FOXP3(-) ex-Treg cells using a newly developed intranuclear staining protocol.
Wed Feb 01 00:00:00 EST 2012
IL-7 abrogates suppressive activity of human CD4+CD25+FOXP3+ regulatory T cells and allows expansion of alloreactive and autoreactive T cells.
Journal of immunology (Baltimore, Md. : 1950)
Heninger AK,Theil A,Wilhelm C,Petzold C,Huebel N,Kretschmer K,Bonifacio E,Monti P
17-4776 was used in Flow cytometry/Cell sorting to explore the possibility that IL-7 may affect the function of CD4(+)CD25(+)FOXP3(+) regulatory T cells (Tregs).
Sat Dec 15 00:00:00 EST 2012
Prostaglandin E2 affects T cell responses through modulation of CD46 expression.
Journal of immunology (Baltimore, Md. : 1950)
Kickler K,Maltby K,Ni Choileain S,Stephen J,Wright S,Hafler DA,Jabbour HN,Astier AL
17-4776 was used in Flow cytometry/Cell sorting to demonstrate a novel role of the PGE(2)-EP4 axis in CD46 functions, which might at least partly explain the diverse roles of PGE(2) in T cell functions.
Fri Jun 01 00:00:00 EDT 2012
TH17, TH22 and Treg cells are enriched in the healthy human cecum.
PloS one
Wolff MJ,Leung JM,Davenport M,Poles MA,Cho I,Loke P
17-4776 was used in Flow cytometry/Cell sorting to characterise CD4+ T cell populations in mucosal pinch biopsies collected from a healthy population.
Fri Dec 07 00:00:00 EST 2012
Calcitriol modulates the CD46 pathway in T cells.
PloS one
Kickler K,Ni Choileain S,Williams A,Richards A,Astier AL
17-4776 was used in Flow cytometry/Cell sorting to investigate whether calcitriol is capable of modulating CD46 expression and function of activated T cells.
Tue Aug 26 00:00:00 EDT 2014
Negative regulation of hepatitis C virus specific immunity is highly heterogeneous and modulated by pegylated interferon-alpha/ribavirin therapy.
PloS one
Claassen MA,de Knegt RJ,Turgut D,Groothuismink ZM,Janssen HL,Boonstra A
17-4776 was used in Flow cytometry/Cell sorting to investigate the impact of pegylated interferon-alpha and ribavirin on the inhibition of T-cell responses against hepatitis C.
Tue Jun 25 00:00:00 EDT 2013
A pilot study of IL-2Rα blockade during lymphopenia depletes regulatory T-cells and correlates with enhanced immunity in patients with glioblastoma.
PloS one
Sampson JH,Schmittling RJ,Archer GE,Congdon KL,Nair SK,Reap EA,Desjardins A,Friedman AH,Friedman HS,Herndon JE,Coan A,McLendon RE,Reardon DA,Vredenburgh JJ,Bigner DD,Mitchell DA
17-4776 was used in Flow cytometry/Cell sorting to examine the combination of daclizumab and EGFRvIII targeted peptide vaccination for depleting regulatory T cells in glioblastoma treated with lymphodepleting temozolomide.
Mon Aug 27 00:00:00 EDT 2012
Reduced cellular susceptibility to in vitro HIV infection is associated with CD4+ T cell quiescence.
PloS one
Card CM,Rutherford WJ,Ramdahin S,Yao X,Kimani M,Wachihi C,Kimani J,Plummer FA,Ball TB,Fowke KR
17-4776 was used in Flow cytometry/Cell sorting to suggest that CD4+ T-cell quiescence hampers the establishment of HIV infection by limiting the pool of activated target cells.
Thu Feb 28 00:00:00 EST 2013
Humoral and cellular immune responses after influenza vaccination in patients with chronic fatigue syndrome.
BMC immunology
Prinsen H,de Vries IJ,Torensma R,Pots JM,Mulder SF,van Herpen CM,Elving LD,Bleijenberg G,Stelma FF,van Laarhoven HW
17-4776 was used in Flow cytometry/Cell sorting to compare the humoral and cellular immune responses upon influenza vaccination in CFS patients and healthy controls.
Mon Dec 17 00:00:00 EST 2012
Interleukin-2 and regulatory T cells in graft-versus-host disease.
The New England journal of medicine
Koreth J,Matsuoka K,Kim HT,McDonough SM,Bindra B,Alyea EP,Armand P,Cutler C,Ho VT,Treister NS,Bienfang DC,Prasad S,Tzachanis D,Joyce RM,Avigan DE,Antin JH,Ritz J,Soiffer RJ
17-4776 was used in Flow cytometry/Cell sorting to assess whether low-dose interleukin-2 could preferentially enhance Treg cells in vivo and suppress clinical manifestations of chronic graft-versus-host disease.
Thu Dec 01 00:00:00 EST 2011
Low telomerase activity in CD4+ regulatory T cells in patients with severe chronic GVHD after hematopoietic stem cell transplantation.
Blood
Kawano Y,Kim HT,Matsuoka K,Bascug G,McDonough S,Ho VT,Cutler C,Koreth J,Alyea EP,Antin JH,Soiffer RJ,Ritz J
17-4776 was used in Flow cytometry/Cell sorting to examine telomere length and telomerase activity of Treg and conventional CD4(+) T cells in patients surviving >2 years following HSC transplant, showing low telomerase activity.
Thu Nov 03 00:00:00 EDT 2011
The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency.
The Journal of experimental medicine
Bigley V,Haniffa M,Doulatov S,Wang XN,Dickinson R,McGovern N,Jardine L,Pagan S,Dimmick I,Chua I,Wallis J,Lordan J,Morgan C,Kumararatne DS,Doffinger R,van der Burg M,van Dongen J,Cant A,Dick JE,Hambleton S,Collin M
17-4776 was used in Flow cytometry/Cell sorting to characterise the phenotypes of different immune compartments in various syndromes of congenital or acquired cellular deficiencies.
Mon Feb 14 00:00:00 EST 2011
Bet v 1-specific T-cell receptor/forkhead box protein 3 transgenic T cells suppress Bet v 1-specific T-cell effector function in an activation-dependent manner.
The Journal of allergy and clinical immunology
Schmetterer KG,Haiderer D,Leb-Reichl VM,Neunkirchner A,Jahn-Schmid B,Küng HJ,Schuch K,Steinberger P,Bohle B,Pickl WF
17-4776 was used in Flow cytometry/Cell sorting to demonstrate a transgenic approach to engineer customised, allergen-specific, human Treg cells, with potential implications for the treatment of allergic diseases.
Sat Jan 01 00:00:00 EST 2011
Retention of CD4+ CD25+ FoxP3+ regulatory T cells in the liver after therapy-induced hepatitis C virus eradication in humans.
Journal of virology
Claassen MA,de Knegt RJ,Janssen HL,Boonstra A
17-4776 was used in Flow cytometry/Cell sorting to provide insight into the dynamics of the immune response to hepatitis C virus and the effect of therapy on intrahepatic immunity.
Wed Jun 01 00:00:00 EDT 2011
Defective response of CD4(+) T cells to retinoic acid and TGFβ in systemic lupus erythematosus.
Arthritis research & therapy
Sobel ES,Brusko TM,Butfiloski EJ,Hou W,Li S,Cuda CM,Abid AN,Reeves WH,Morel L
17-4776 was used in Flow cytometry/Cell sorting to investigate the impaired integration of the TGFβ and RA signals in SLE T cells and implicate the PBX1 gene in this process.
Mon Jun 27 00:00:00 EDT 2011
Transfer of regulatory properties from tolerogenic to proinflammatory dendritic cells via induced autoreactive regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Kleijwegt FS,Laban S,Duinkerken G,Joosten AM,Koeleman BP,Nikolic T,Roep BO
17-4776 was used in Flow cytometry/Cell sorting to study the mechanism by which infectious tolerance applies to human dendritic cells.
Thu Dec 15 00:00:00 EST 2011
Regulatory and activated T cells in human Schistosoma haematobium infections.
PloS one
Nausch N,Midzi N,Mduluza T,Maizels RM,Mutapi F
17-4776 was used in Flow cytometry/Cell sorting to investigate the relationship between schistosome infection intensity and Tregs and activated T cells.
Thu Feb 10 00:00:00 EST 2011
Comparative approach to define increased regulatory T cells in different cancer subtypes by combined assessment of CD127 and FOXP3.
Clinical & developmental immunology
Beyer M,Classen S,Endl E,Kochanek M,Weihrauch MR,Debey-Pascher S,Knolle PA,Schultze JL
17-4776 was used in Flow cytometry/Cell sorting to support superiority of combined CD127 and FOXP3 analysis in comparison to CD25 and FOXP3 assessment for further quantification of T(reg) cells in malignant diseases.
Mon Jan 09 00:00:00 EST 2012
Bovine lactoferrin counteracts Toll-like receptor mediated activation signals in antigen presenting cells.
PloS one
Puddu P,Latorre D,Carollo M,Catizone A,Ricci G,Valenti P,Gessani S
17-4776 was used in Flow cytometry/Cell sorting to show that bLF-mediated effects may represent a strategy to block excessive DC activation upon TLR-induced inflammation.
Tue Dec 06 00:00:00 EST 2011
Altered regulatory T cell homeostasis in patients with CD4+ lymphopenia following allogeneic hematopoietic stem cell transplantation.
The Journal of clinical investigation
Matsuoka K,Kim HT,McDonough S,Bascug G,Warshauer B,Koreth J,Cutler C,Ho VT,Alyea EP,Antin JH,Soiffer RJ,Ritz J
17-4776 was used in Flow cytometry/Cell sorting to indicate that CD4+ lymphopenia is a critical factor in Treg homeostasis and that its imbalance can result in loss of tolerance and clinical disease manifestations.
Sat May 01 00:00:00 EDT 2010
Inducing CTLA-4-dependent immune regulation by selective CD28 blockade promotes regulatory T cells in organ transplantation.
Science translational medicine
Poirier N,Azimzadeh AM,Zhang T,Dilek N,Mary C,Nguyen B,Tillou X,Wu G,Reneaudin K,Hervouet J,Martinet B,Coulon F,Allain-Launay E,Karam G,Soulillou JP,Pierson RN,Blancho G,Vanhove B
17-4776 was used in Immunohistochemistry to suggest that targeting costimulation blockade at CD28 favors CTLA-4-dependent immune regulation and promotes allograft survival.
Wed Feb 03 00:00:00 EST 2010
Phenotypic analysis of human peripheral blood regulatory T cells (CD4+FOXP3+CD127lo/-) ex vivo and after in vitro restimulation with malaria antigens.
European journal of immunology
Finney OC,Riley EM,Walther M
17-4776 was used in Flow cytometry/Cell sorting to analyse the phenotype of human peripheral blood regulatory T cells ex vivo and after in vitro restimulation with malaria antigens.
Fri Jan 01 00:00:00 EST 2010
Frequency of CD4(+)CD25(hi)FOXP3(+) regulatory T cells has diagnostic and prognostic value as a biomarker for acute graft-versus-host-disease.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Magenau JM,Qin X,Tawara I,Rogers CE,Kitko C,Schlough M,Bickley D,Braun TM,Jang PS,Lowler KP,Jones DM,Choi SW,Reddy P,Mineishi S,Levine JE,Ferrara JL,Paczesny S
17-4776 was used in Flow cytometry/Cell sorting to conduct a prospective analysis of peripheral blood Tregs as determined by the frequency of CD4(+)CD25(hi)FOXP3(+) lymphocytes in 215 BMT patients.
Thu Jul 01 00:00:00 EDT 2010
Delaying bacillus Calmette-Guérin vaccination from birth to 4 1/2 months of age reduces postvaccination Th1 and IL-17 responses but leads to comparable mycobacterial responses at 9 months of age.
Journal of immunology (Baltimore, Md. : 1950)
Burl S,Adetifa UJ,Cox M,Touray E,Ota MO,Marchant A,Whittle H,McShane H,Rowland-Jones SL,Flanagan KL
17-4776 was used in Flow cytometry/Cell sorting to suggest that vaccination at birth induces a broad Th1/Th2/IL-17/Treg mycobacterial response but the Th1/Th-17 response was reduced when delaying the vaccine.
Sun Aug 15 00:00:00 EDT 2010
Naive human T cells are activated and proliferate in response to the heme oxygenase-1 inhibitor tin mesoporphyrin.
Journal of immunology (Baltimore, Md. : 1950)
Burt TD,Seu L,Mold JE,Kappas A,McCune JM
17-4776 was used in Flow cytometry/Cell sorting to investigate whether HO-1 plays a role in the homeostatic control of T cell activation and proliferation.
Mon Nov 01 00:00:00 EDT 2010
Increased sensitivity of CD4+ T-effector cells to CD4+CD25+ Treg suppression compensates for reduced Treg number in asymptomatic HIV-1 infection.
PloS one
Thorborn G,Pomeroy L,Isohanni H,Perry M,Peters B,Vyakarnam A
17-4776 was used in Flow cytometry/Cell sorting to report that elevated Treg-mediated suppression may be a natural host response to HIV infection.
Wed Feb 17 00:00:00 EST 2010
TRAIL death receptor-4, decoy receptor-1 and decoy receptor-2 expression on CD8+ T cells correlate with the disease severity in patients with rheumatoid arthritis.
BMC musculoskeletal disorders
Bisgin A,Terzioglu E,Aydin C,Yoldas B,Yazisiz V,Balci N,Bagci H,Gorczynski RM,Akdis CA,Sanlioglu S
17-4776 was used in Flow cytometry/Cell sorting to study disease severity in patients with rheumatoid arthritis via TRAIL death receptor-4, decoy receptor-1 and decoy receptor-2 expression on CD8+ T cells.
Fri Aug 27 00:00:00 EDT 2010
Biologic predictors of extension of oligoarticular juvenile idiopathic arthritis as determined from synovial fluid cellular composition and gene expression.
Arthritis and rheumatism
Hunter PJ,Nistala K,Jina N,Eddaoudi A,Thomson W,Hubank M,Wedderburn LR
17-4776 was used in Flow cytometry/Cell sorting to identify disease severity biomarkers in the first synovial fluid aspirate obtained from children with oligoarticular juvenile idiopathic arthritis.
Mon Mar 01 00:00:00 EST 2010
CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury.
The Journal of clinical investigation
D'Alessio FR,Tsushima K,Aggarwal NR,West EE,Willett MH,Britos MF,Pipeling MR,Brower RG,Tuder RM,McDyer JF,King LS
17-4776 was used in Flow cytometry/Cell sorting to examine the role of regulatory T cells in the resolution of acute lung injury.
Thu Oct 01 00:00:00 EDT 2009
Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue.
Cancer research
Wieczorek G,Asemissen A,Model F,Turbachova I,Floess S,Liebenberg V,Baron U,Stauch D,Kotsch K,Pratschke J,Hamann A,Loddenkemper C,Stein H,Volk HD,Hoffmüller U,Grützkau A,Mustea A,Huehn J,Scheibenbogen C,Olek S
17-4776 was used in Flow cytometry/Cell sorting to demonstrate a novel method for monitoring Treg cells in human peripheral blood and solid tissues based on Treg-specific DNA demethylation.
Thu Jan 15 00:00:00 EST 2009
Parasite-dependent expansion of TNF receptor II-positive regulatory T cells with enhanced suppressive activity in adults with severe malaria.
PLoS pathogens
Minigo G,Woodberry T,Piera KA,Salwati E,Tjitra E,Kenangalem E,Price RN,Engwerda CR,Anstey NM,Plebanski M
17-4776 was used in Flow cytometry/Cell sorting to investigate the relationship between regulatory T cells, parasite biomass, and Plasmodium falciparum malaria disease severity in adults living in a malaria-endemic region of Indonesia.
Wed Apr 01 00:00:00 EDT 2009
Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation.
European journal of immunology
Hoffmann P,Boeld TJ,Eder R,Huehn J,Floess S,Wieczorek G,Olek S,Dietmaier W,Andreesen R,Edinger M
17-4776 was used in Flow cytometry/Cell sorting to study the epigenetic regulation of the FOXP3 gene locus in regulatory T cells following repetitive in vitro stimulation.
Wed Apr 01 00:00:00 EDT 2009
1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3.
Journal of immunology (Baltimore, Md. : 1950)
Jeffery LE,Burke F,Mura M,Zheng Y,Qureshi OS,Hewison M,Walker LS,Lammas DA,Raza K,Sansom DM
17-4776 was used in Flow cytometry/Cell sorting to assess the effects of the active form of vitamin D, 1,25-dihydroxyvitamin D(3) on human CD4(+)CD25(-) T cells.
Sun Nov 01 00:00:00 EDT 2009
Determinants of in vitro expansion of different human virus-specific FoxP3+ regulatory CD8+ T cells in chronic hepatitis C virus infection.
The Journal of general virology
Billerbeck E,Nakamoto N,Seigel B,Blum HE,Chang KM,Thimme R
17-4776 was used in Flow cytometry/Cell sorting to suggest that the ability to expand FoxP3+ regulatory CD8+ T cells from virus-specific CD8+ T cells depends on differentiation status.
Wed Jul 01 00:00:00 EDT 2009
Regulatory and pro-inflammatory phenotypes of myelin basic protein-autoreactive T cells in multiple sclerosis.
International immunology
Hong J,Li H,Chen M,Zang YC,Skinner SM,Killian JM,Zhang JZ
17-4776 was used in Flow cytometry to provide evidence that MBP-specific T-cells are susceptible to pro-inflammatory cytokine milieu and act as pro-inflammatory or regulatory T-cells.
Tue Dec 01 00:00:00 EST 2009
Rabbit ATG but not horse ATG promotes expansion of functional CD4+CD25highFOXP3+ regulatory T cells in vitro.
Blood
Feng X,Kajigaya S,Solomou EE,Keyvanfar K,Xu X,Raghavachari N,Munson PJ,Herndon TM,Chen J,Young NS
17-4776 was used in Flow cytometry/Cell sorting to observe the differences between horse and rabbit antithymocyte globulin (ATG) on the expansion of functional CD4+CD25highFOXP3+ regulatory T cell populations.
Tue Apr 01 00:00:00 EDT 2008
FOXP3 expression accurately defines the population of intratumoral regulatory T cells that selectively accumulate in metastatic melanoma lesions.
Blood
Ahmadzadeh M,Felipe-Silva A,Heemskerk B,Powell DJ,Wunderlich JR,Merino MJ,Rosenberg SA
17-4776 was used in Flow cytometry/Cell sorting to investigate the functional characteristics of Tregs in human tumours.
Mon Dec 15 00:00:00 EST 2008
Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys.
The Journal of clinical investigation
Klatt NR,Villinger F,Bostik P,Gordon SN,Pereira L,Engram JC,Mayne A,Dunham RM,Lawson B,Ratcliffe SJ,Sodora DL,Else J,Reimann K,Staprans SI,Haase AT,Estes JD,Silvestri G,Ansari AA
17-4776 was used in Flow cytometry/Cell sorting to elucidate the factors dictating viremia in naturally SIV-infected sooty mangabeys, most importantly, the level of proliferating CD4+ T cells, which was correlated with viral replication.
Sun Jun 01 00:00:00 EDT 2008
The kinetics of CD4+Foxp3+ T cell accumulation during a human cutaneous antigen-specific memory response in vivo.
The Journal of clinical investigation
Vukmanovic-Stejic M,Agius E,Booth N,Dunne PJ,Lacy KE,Reed JR,Sobande TO,Kissane S,Salmon M,Rustin MH,Akbar AN
17-4776 was used in Flow cytometry/Cell sorting to describe the in vivo response of human CD4+Foxp3+ T cells to tuberculin purified protein derivative injected into the skin.
Sat Nov 01 00:00:00 EDT 2008
Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing.
Clinical cancer research : an official journal of the American Association for Cancer Research
Sfanos KS,Bruno TC,Maris CH,Xu L,Thoburn CJ,DeMarzo AM,Meeker AK,Isaacs WB,Drake CG
17-4776 was used in Flow cytometry/Cell sorting to reveal a potential role for TH17 and regulatory CD4+ T cells in the development or progression of prostate cancer.
Sun Jun 01 00:00:00 EDT 2008
Differential regulation of naïve and memory CD4+ T cells by alternatively activated dendritic cells.
Journal of leukocyte biology
Anderson AE,Sayers BL,Haniffa MA,Swan DJ,Diboll J,Wang XN,Isaacs JD,Hilkens CM
17-4776 was used in Flow cytometry/Cell sorting to find that alternately activated dendritic cells differentially regulate naïve and memory T cells.
Tue Jul 01 00:00:00 EDT 2008
Suppressive efficacy and proliferative capacity of human regulatory T cells in allogeneic and xenogeneic responses.
Transplantation
Lin YJ,Hara H,Tai HC,Long C,Tokita D,Yeh P,Ayares D,Morelli AE,Cooper DK
17-4776 was used in Flow cytometry/Cell sorting to investigate the ability of human regulatory T cells to suppress xenogeneic and allogeneic responses in vitro, to better understand the human anti-pig cellular response.
Thu Nov 27 00:00:00 EST 2008
Suppressive efficacy and proliferative capacity of human regulatory T cells in allogeneic and xenogeneic responses.
Transplantation
Lin YJ,Hara H,Tai HC,Long C,Tokita D,Yeh P,Ayares D,Morelli AE,Cooper DK
17-4776 was used in Flow cytometry/Cell sorting to investigate the ability of human regulatory T cells to suppress xenogeneic and allogeneic responses in vitro, to better understand the human anti-pig cellular response.
Thu Nov 27 00:00:00 EST 2008
STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells.
International immunology
Passerini L,Allan SE,Battaglia M,Di Nunzio S,Alstad AN,Levings MK,Roncarolo MG,Bacchetta R
17-4776 was used in Flow cytometry/Cell sorting to investigate whether activated T effector cells expresses Foxp3.
Sat Mar 01 00:00:00 EST 2008
CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes.
The Journal of allergy and clinical immunology
Caudy AA,Reddy ST,Chatila T,Atkinson JP,Verbsky JW
17-4776 was used in Flow cytometry/Cell sorting to determine if Foxp3 is required for the generation of IL-10-expressing T regulatory cells in relation to immune dysregulation.
Thu Feb 01 00:00:00 EST 2007
FoxP3+ CD25+ CD8+ T-cell induction during primary simian immunodeficiency virus infection in cynomolgus macaques correlates with low CD4+ T-cell activation and high viral load.
Journal of virology
Karlsson I,Malleret B,Brochard P,Delache B,Calvo J,Le Grand R,Vaslin B
17-4776 was used in Immunofluorescence to monitor the dynamics of CD25(+) FoxP3(+) T cells during primary and chronic SIVmac251 infection in cynomolgus macaques.
Sat Dec 01 00:00:00 EST 2007
The maintenance of human CD4+ CD25+ regulatory T cell function: IL-2, IL-4, IL-7 and IL-15 preserve optimal suppressive potency in vitro.
International immunology
Yates J,Rovis F,Mitchell P,Afzali B,Tsang J,Garin M,Lechler RI,Lombardi G,Garden OA
17-4776 was used in Flow cytometry/Cell sorting to suggest a model in which IL-2, IL-4, IL-7 and IL-15 maintain optimal regulatory function of human CD4+ CD25+ T-cells.
Fri Jun 01 00:00:00 EDT 2007
IL-2 and IL-15 each mediate de novo induction of FOXP3 expression in human tumor antigen-specific CD8 T cells.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Ahmadzadeh M,Antony PA,Rosenberg SA
17-4776 was used in Flow cytometry/Cell sorting to indicate that induction of FOXP3 is intrinsic to CD8 T cells that are activated in the presence of IL-2 or IL-15.
Sun Apr 01 00:00:00 EDT 2007
Pharmacokinetics, toxicity, and functional studies of the selective Kv1.3 channel blocker 5-(4-phenoxybutoxy)psoralen in rhesus macaques.
Experimental biology and medicine (Maywood, N.J.)
Pereira LE,Villinger F,Wulff H,Sankaranarayanan A,Raman G,Ansari AA
17-4776 was used in Flow cytometry/Cell sorting to investigate the in vitro effects of PAP-1 in rhesus macaques.
Thu Nov 01 00:00:00 EDT 2007
Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion.
Blood
Hoffmann P,Eder R,Boeld TJ,Doser K,Piseshka B,Andreesen R,Edinger M
17-4776 was used in Flow cytometry/Cell sorting to suggest that isolation and expansion of CD45RA+ naive CD4+ CD25high T cells is ideal for adoptive regulatory T (Treg)-cell therapies.
Fri Dec 15 00:00:00 EST 2006
TNF downmodulates the function of human CD4+CD25hi T-regulatory cells.
Blood
Valencia X,Stephens G,Goldbach-Mansky R,Wilson M,Shevach EM,Lipsky PE
17-4776 was used in Flow cytometry/Cell sorting to demonstrate a novel action of TNF in modulating autoimmunity by inhibiting CD4+CD25+ regulatory T cell activity.
Sat Jul 01 00:00:00 EDT 2006
Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART.
Blood
Epple HJ,Loddenkemper C,Kunkel D,Tröger H,Maul J,Moos V,Berg E,Ullrich R,Schulzke JD,Stein H,Duchmann R,Zeitz M,Schneider T
Wed Nov 01 00:00:00 EST 2006
Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Lim HW,Hillsamer P,Banham AH,Kim CH
Sat Oct 01 00:00:00 EDT 2005
