Product References
ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy.
Nature communications
Xiao X,Shi J,He C,Bu X,Sun Y,Gao M,Xiang B,Xiong W,Dai P,Mao Q,Xing X,Yao Y,Yu H,Xu G,Li S,Ren Y,Chen B,Jiang C,Meng G,Lee YR,Wei W,Freeman GJ,Xie C,Zhang J
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Fri May 19 00:00:00 EDT 2023
Small-molecule PTPN2 Inhibitors Sensitize Resistant Melanoma to Anti-PD-1 Immunotherapy.
Cancer research communications
Zhu Z,Tang R,Huff S,Kummetha IR,Wang L,Li N,Rana TM
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2023
BRCA1 deficiency in mature CD8+ T lymphocytes impairs antitumor immunity.
Journal for immunotherapy of cancer
Wu B,Qi L,Chiang HC,Pan H,Zhang X,Greenbaum A,Stark E,Wang LJ,Chen Y,Haddad BR,Clagett D,Isaacs C,Elledge R,Horvath A,Hu Y,Li R
12-8898-82 was used in Flow cytometry/Cell sorting to report that mouse Brca1 knockout (KO) in mature T lymphocytes compromises host antitumor immune response to transplanted syngeneic mouse mammary tumors.
Wed Feb 01 00:00:00 EST 2023
Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ-stimulated antitumor immunity.
The Journal of clinical investigation
Ren J,Li N,Pei S,Lian Y,Li L,Peng Y,Liu Q,Guo J,Wang X,Han Y,Zhang G,Wang H,Li Y,Jiang J,Li Q,Tan M,Peng J,Hu G,Xiao Y,Li X,Lin M,Qin J
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Fri Apr 15 00:00:00 EDT 2022
Wnt5A Signaling Blocks Progression of Experimental Visceral Leishmaniasis.
Frontiers in immunology
Maity S,Chakraborty A,Mahata SK,Roy S,Das AK,Sen M
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Tue Mar 22 00:00:00 EDT 2022
Intranasal Delivery of Recombinant S100A8 Protein Delays Lung Cancer Growth by Remodeling the Lung Immune Microenvironment.
Frontiers in immunology
Wong SW,McCarroll J,Hsu K,Geczy CL,Tedla N
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Mon Jun 06 00:00:00 EDT 2022
eEF2K promotes PD-L1 stabilization through inactivating GSK3β in melanoma.
Journal for immunotherapy of cancer
Chen X,Wang K,Jiang S,Sun H,Che X,Zhang M,He J,Wen Y,Liao M,Li X,Zhou X,Song J,Ren X,Yi W,Yang J,Chen X,Yin M,Cheng Y
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2022
RAD21 amplification epigenetically suppresses interferon signaling to promote immune evasion in ovarian cancer.
The Journal of clinical investigation
Deng P,Wang Z,Chen J,Liu S,Yao X,Liu S,Liu L,Yu Z,Huang Y,Xiong Z,Xiao R,Gao J,Liang W,Chen J,Liu H,Hong JH,Chan JY,Guan P,Chen J,Wang Y,Yin J,Li J,Zheng M,Zhang C,Zhou P,Kang T,Teh BT,Yu Q,Zuo Z,Jiang Q,Liu J,Xiong Y,Xia X,Tan J
12-8898-82 was used in Flow cytometry/Cell sorting to identify a RAD21-YAP/TEAD4-NuRD corepressor complex in immune modulation, and thus provides a potential target and biomarker for precision immunotherapy in OV.
Tue Nov 15 00:00:00 EST 2022
RAD21 amplification epigenetically suppresses interferon signaling to promote immune evasion in ovarian cancer.
The Journal of clinical investigation
Deng P,Wang Z,Chen J,Liu S,Yao X,Liu S,Liu L,Yu Z,Huang Y,Xiong Z,Xiao R,Gao J,Liang W,Chen J,Liu H,Hong JH,Chan JY,Guan P,Chen J,Wang Y,Yin J,Li J,Zheng M,Zhang C,Zhou P,Kang T,Teh BT,Yu Q,Zuo Z,Jiang Q,Liu J,Xiong Y,Xia X,Tan J
12-8898-82 was used in Flow cytometry/Cell sorting to identify a RAD21-YAP/TEAD4-NuRD corepressor complex in immune modulation, and thus provides a potential target and biomarker for precision immunotherapy in OV.
Tue Nov 15 00:00:00 EST 2022
PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells.
Nature communications
Li Q,Zhang L,You W,Xu J,Dai J,Hua D,Zhang R,Yao F,Zhou S,Huang W,Dai Y,Zhang Y,Baheti T,Qian X,Pu L,Xu J,Xia Y,Zhang C,Tang J,Wang X
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Mon Dec 12 00:00:00 EST 2022
Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy.
Cell reports
Wang W,Wu S,Cen Z,Zhang Y,Chen Y,Huang Y,Cillo AR,Prokopec JS,Quarato G,Vignali DAA,Stewart-Ornstein J,Li S,Lu B,Gong YN
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Tue Nov 01 00:00:00 EDT 2022
Activated Natural Killer Cell Promotes Nonalcoholic Steatohepatitis Through Mediating JAK/STAT Pathway.
Cellular and molecular gastroenterology and hepatology
Wang F,Zhang X,Liu W,Zhou Y,Wei W,Liu D,Wong CC,Sung JJY,Yu J
12-8898-82 was used in Flow cytometry/Cell sorting to aim to investigate the functional significance of NK cells in NASH evolution.
Mon Apr 04 00:00:00 EDT 2022
Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity.
Cancer cell
Chryplewicz A,Scotton J,Tichet M,Zomer A,Shchors K,Joyce JA,Homicsko K,Hanahan D
12-8898-82 was used in flow cytometry to assess this concept by combining vascular endothelial growth factor (VEGF) pathway inhibitors that remodel the tumor vasculature with the tricyclic antidepressant imipramine, which enhances autophagy in GBM cancer cells and unexpectedly reprograms immunosuppressive tumor-associated macrophages via inhibition of histamine receptor signaling to become immunostimulatory.
Mon Oct 10 00:00:00 EDT 2022
Pharmacological disruption of the MTDH-SND1 complex enhances tumor antigen presentation and synergizes with anti-PD-1 therapy in metastatic breast cancer.
Nature cancer
Shen M,Smith HA,Wei Y,Jiang YZ,Zhao S,Wang N,Rowicki M,Tang Y,Hang X,Wu S,Wan L,Shao ZM,Kang Y
12-8898-82 was used in Flow Cytometry to reveal a key role for this complex in suppressing antitumor T cell responses in breast cancer.
Sat Jan 01 00:00:00 EST 2022
Mapping and role of T cell response in SARS-CoV-2-infected mice.
The Journal of experimental medicine
Zhuang Z,Lai X,Sun J,Chen Z,Zhang Z,Dai J,Liu D,Li Y,Li F,Wang Y,Zhu A,Wang J,Yang W,Huang J,Li X,Hu L,Wen L,Zhuo J,Zhang Y,Chen D,Li S,Huang S,Shi Y,Zheng K,Zhong N,Zhao J,Zhou D,Zhao J
12-8898 was used in Flow cytometry/Cell sorting to demonstrate cross-reactive T cell responses between SARS-CoV and SARS-CoV-2, but not MERS-CoV, in mice.
Mon Apr 05 00:00:00 EDT 2021
Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function.
Cell reports
Daneshmandi S,Cassel T,Lin P,Higashi RM,Wulf GM,Boussiotis VA,Fan TW,Seth P
12-8898-82 was used in Flow cytometry/Cell sorting to show that genetic ablation or pharmacologic inhibition of the PPP enzyme 6-phosphogluconate dehydrogenase (6PGD) in the oxidative PPP results in the generation of superior CD8+ T effector cells.
Tue Mar 09 00:00:00 EST 2021
Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function.
Cell reports
Daneshmandi S,Cassel T,Lin P,Higashi RM,Wulf GM,Boussiotis VA,Fan TW,Seth P
12-8898-82 was used in Flow cytometry/Cell sorting to show that genetic ablation or pharmacologic inhibition of the PPP enzyme 6-phosphogluconate dehydrogenase (6PGD) in the oxidative PPP results in the generation of superior CD8+ T effector cells.
Tue Mar 09 00:00:00 EST 2021
Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy.
Cell reports
Dodagatta-Marri E,Ma HY,Liang B,Li J,Meyer DS,Chen SY,Sun KH,Ren X,Zivak B,Rosenblum MD,Headley MB,Pinzas L,Reed NI,Del Cid JS,Hann BC,Yang S,Giddabasappa A,Noorbehesht K,Yang B,Dal Porto J,Tsukui T,Niessen K,Atakilit A,Akhurst RJ,Sheppard D
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Tue Jul 06 00:00:00 EDT 2021
Aiduqing formula inhibits breast cancer metastasis by suppressing TAM/CXCL1-induced Treg differentiation and infiltration.
Cell communication and signaling : CCS
Li J,Wang S,Wang N,Zheng Y,Yang B,Wang X,Zhang J,Pan B,Wang Z
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Mon Aug 30 00:00:00 EDT 2021
Extracellular Vesicles from Akkermansia muciniphila Elicit Antitumor Immunity Against Prostate Cancer via Modulation of CD8+ T Cells and Macrophages.
International journal of nanomedicine
Luo ZW,Xia K,Liu YW,Liu JH,Rao SS,Hu XK,Chen CY,Xu R,Wang ZX,Xie H
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Tue Jun 01 00:00:00 EDT 2021
Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection.
iScience
Steele L,Mannion AJ,Shaw G,Maclennan KA,Cook GP,Rudd CE,Taylor A
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Fri Jun 25 00:00:00 EDT 2021
Circadian Clock Disruption Suppresses PDL1+ Intraepithelial B Cells in Experimental Colitis and Colitis-Associated Colorectal Cancer.
Cellular and molecular gastroenterology and hepatology
Liu JL,Wang CY,Cheng TY,Rixiati Y,Ji C,Deng M,Yao S,Yuan LH,Zhao YY,Shen T,Li JM
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Mon Jan 24 00:00:00 EST 2022
Knockout of immunotherapy prognostic marker genes eliminates the effect of the anti-PD-1 treatment.
NPJ precision oncology
Yang N,Ji F,Cheng L,Lu J,Sun X,Lin X,Lan X
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Fri May 07 00:00:00 EDT 2021
WSX1 act as a tumor suppressor in hepatocellular carcinoma by downregulating neoplastic PD-L1 expression.
Nature communications
Wu M,Xia X,Hu J,Fowlkes NW,Li S
12-8898-82 was used in Flow Cytometry to yield insights into the host homeostatic control of immune response and benefit the development of cancer immunotherapies.
Wed Jun 09 00:00:00 EDT 2021
SRC-3 Functions as a Coactivator of T-bet by Regulating the Maturation and Antitumor Activity of Natural Killer Cells.
Cancer immunology research
Hu M,Lu Y,Qi Y,Zhang Z,Wang S,Xu Y,Chen F,Tang Y,Chen S,Chen M,Du C,Shen M,Wang F,Su Y,Deng Y,Wang J
12-8898-82 was used in Flow Cytometry to study the role of SRC-3 as a coactivator of T-bet in natural killer-cell biology and indicate that targeting SRC-3 may be a promising strategy to increase the tumor surveillance function of natural killer cells.
Tue Sep 01 00:00:00 EDT 2020
Calpain mediated expansion of CD4+ cytotoxic T cells in rodent models of Parkinson's disease.
Experimental neurology
Haque A,Samantaray S,Knaryan VH,Capone M,Hossain A,Matzelle D,Chandran R,Shields DC,Farrand AQ,Boger HA,Banik NL
12-8898 was used in Flow cytometry/Cell sorting to report an increased expression of a subset of CD4+ T cells in rodent models of PD, including MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mice and DSP-4 [N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride]/6-hydroxydopamine rats, which produced higher levels of perforin and granzyme B - typically found in cytotoxic T cells.
Sat Aug 01 00:00:00 EDT 2020
Assessment of the WAP-Myc mouse mammary tumor model for spontaneous metastasis.
Scientific reports
Utz B,Turpin R,Lampe J,Pouwels J,Klefström J
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Fri Oct 30 00:00:00 EDT 2020
Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Restructures the Immune Contexture to Improve Checkpoint Blockade Efficacy.
Biomedicines
Ebelt ND,Zuniga E,Marzagalli M,Zamloot V,Blazar BR,Salgia R,Manuel ER
12-8898 was used in Flow cytometry/Cell sorting to suggest that the success of ICB therapy may be more accurately predicted by taking into account multiple factors such as potential for antigen presentation and immune subset repertoire in addition to markers already being considered.
Wed Dec 16 00:00:00 EST 2020
Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Restructures the Immune Contexture to Improve Checkpoint Blockade Efficacy.
Biomedicines
Ebelt ND,Zuniga E,Marzagalli M,Zamloot V,Blazar BR,Salgia R,Manuel ER
12-8898 was used in Flow cytometry/Cell sorting to suggest that the success of ICB therapy may be more accurately predicted by taking into account multiple factors such as potential for antigen presentation and immune subset repertoire in addition to markers already being considered.
Wed Dec 16 00:00:00 EST 2020
Memory CD73+IgM+ B cells protect against Plasmodium yoelii infection and express Granzyme B.
PloS one
Parra M,Weitner M,Yang A,Akue A,Liu X,Schmidt T,Allman WR,Akkoyunlu M,Derrick SC
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Tue Oct 27 00:00:00 EDT 2020
Memory CD73+IgM+ B cells protect against Plasmodium yoelii infection and express Granzyme B.
PloS one
Parra M,Weitner M,Yang A,Akue A,Liu X,Schmidt T,Allman WR,Akkoyunlu M,Derrick SC
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Tue Oct 27 00:00:00 EDT 2020
Antigen-Based Nano-Immunotherapy Controls Parasite Persistence, Inflammatory and Oxidative Stress, and Cardiac Fibrosis, the Hallmarks of Chronic Chagas Cardiomyopathy, in A Mouse Model of Trypanosoma cruzi Infection.
Vaccines
Lokugamage N,Choudhuri S,Davies C,Chowdhury IH,Garg NJ
12-8898-82 was used in Flow Cytometry to clone TcG2 and TcG4 in a nanovector and evaluate whether nano-immunotherapy offers resistance to chronic Chagas disease.
Fri Feb 21 00:00:00 EST 2020
Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models.
Communications biology
Waaler J,Mygland L,Tveita A,Strand MF,Solberg NT,Olsen PA,Aizenshtadt A,Fauskanger M,Lund K,Brinch SA,Lycke M,Dybing E,Nygaard V,Bøe SL,Heintz KM,Hovig E,Hammarström C,Corthay A,Krauss S
12-8898 was used in Flow Cytometry to show that a specific small-molecule tankyrase inhibitor, G007-LK, decreases WNT/β-catenin and YAP signaling in the syngeneic murine B16-F10 and Clone M-3 melanoma models and sensitizes the tumors to anti-PD-1 immune checkpoint therapy.
Fri Apr 24 00:00:00 EDT 2020
Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury.
Cell
Davies AJ,Kim HW,Gonzalez-Cano R,Choi J,Back SK,Roh SE,Johnson E,Gabriac M,Kim MS,Lee J,Lee JE,Kim YS,Bae YC,Kim SJ,Lee KM,Na HS,Riva P,Latremoliere A,Rinaldi S,Ugolini S,Costigan M,Oh SB
12-8898 was used in Flow Cytometry to suggest the therapeutic potential of modulating NK cell function to resolve painful neuropathy through the clearance of partially damaged nerves.
Thu Feb 07 00:00:00 EST 2019
Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells.
Cell
Miao Y,Yang H,Levorse J,Yuan S,Polak L,Sribour M,Singh B,Rosenblum MD,Fuchs E
12-8898 was used in Flow cytometry/Cell sorting to place tSCs at the crux of how immune checkpoint pathways are activated.
Thu May 16 00:00:00 EDT 2019
cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.
The Journal of clinical investigation
Wang Z,Chen J,Hu J,Zhang H,Xu F,He W,Wang X,Li M,Lu W,Zeng G,Zhou P,Huang P,Chen S,Li W,Xia LP,Xia X
12-8898 was used in Flow cytometry/Cell sorting to show that teniposide could trigger tumor immunogenicity and enable a potential chemoimmunotherapeutic approach to potentiating the therapeutic efficacy of anti-PD1 immunotherapy.
Tue Aug 13 00:00:00 EDT 2019
Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy.
Nature communications
Shi L,Wang J,Ding N,Zhang Y,Zhu Y,Dong S,Wang X,Peng C,Zhou C,Zhou L,Li X,Shi H,Wu W,Long X,Wu C,Liao W
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Thu Nov 28 00:00:00 EST 2019
Carbon ion irradiation enhances the antitumor efficacy of dual immune checkpoint blockade therapy both for local and distant sites in murine osteosarcoma.
Oncotarget
Takahashi Y,Yasui T,Minami K,Tamari K,Hayashi K,Otani K,Seo Y,Isohashi F,Koizumi M,Ogawa K
12-8898 was used in Flow cytometry/Cell sorting to understand the efficacy of combining carbon ion irradiation and dual immune checkpoint blockade therapy to treat local and distant sites in osteosarcoma in mice.
Fri Jan 18 00:00:00 EST 2019
Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes.
Frontiers in immunology
Liu C,Whitener RL,Lin A,Xu Y,Chen J,Savinov A,Leiding JW,Wallet MA,Mathews CE
12-8898-82 was used in Flow Cytometry to demonstrate that Ncf1 (p47phox) is required for activation and effector function of CD8+ T cells by acting both intrinsically within the T cell as well as within professional antigen presenting cells.
Wed Sep 09 00:00:00 EDT 2020
Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells.
JCI insight
Huang A,Shinde PV,Huang J,Senff T,Xu HC,Margotta C,Häussinger D,Willnow TE,Zhang J,Pandyra AA,Timm J,Weggen S,Lang KS,Lang PA
12-8898 was used in Flow cytometry/Cell sorting to show that progranulin (PGRN) can reduce NK cell cytotoxicity through reduction of NK cell expansion, granzyme B transcription, and NK cell-mediated lysis of target cells.
Thu Sep 05 00:00:00 EDT 2019
Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors.
Immunity
Sharma MD,Rodriguez PC,Koehn BH,Baban B,Cui Y,Guo G,Shimoda M,Pacholczyk R,Shi H,Lee EJ,Xu H,Johnson TS,He Y,Mergoub T,Venable C,Bronte V,Wolchok JD,Blazar BR,Munn DH
12-8898 was used in Flow cytometry/Cell sorting to show that during immunotherapy large numbers of cells expressing CD103 arose in murine tumours via direct differentiation of Ly6c+ monocytic precursors.
Tue Jan 16 00:00:00 EST 2018
CD4+ T Cell Fate Decisions Are Stochastic, Precede Cell Division, Depend on GITR Co-Stimulation, and Are Associated With Uropodium Development.
Frontiers in immunology
Cobbold SP,Adams E,Howie D,Waldmann H
Mon Jan 31 00:00:00 EST 2022
MAIT cells contribute to protection against lethal influenza infection in vivo.
Nature communications
van Wilgenburg B,Loh L,Chen Z,Pediongco TJ,Wang H,Shi M,Zhao Z,Koutsakos M,Nüssing S,Sant S,Wang Z,D'Souza C,Jia X,Almeida CF,Kostenko L,Eckle SBG,Meehan BS,Kallies A,Godfrey DI,Reading PC,Corbett AJ,McCluskey J,Klenerman P,Kedzierska K,Hinks TSC
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Fri Nov 09 00:00:00 EST 2018
Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function.
Nature communications
Wang F,Meng M,Mo B,Yang Y,Ji Y,Huang P,Lai W,Pan X,You T,Luo H,Guan X,Deng Y,Yuan S,Chu J,Namaka M,Hughes T,Ye L,Yu J,Li X,Deng Y
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Mon Nov 19 00:00:00 EST 2018
Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis.
Nature communications
Kim DH,Park HJ,Lim S,Koo JH,Lee HG,Choi JO,Oh JH,Ha SJ,Kang MJ,Lee CM,Lee CG,Elias JA,Choi JM
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Mon Feb 05 00:00:00 EST 2018
A purified, fermented, extract of Triticum aestivum has lymphomacidal activity mediated via natural killer cell activation.
PloS one
Barisone GA,O'Donnell RT,Ma Y,Abuhay MW,Lundeberg K,Gowda S,Tuscano JM
12-8898 was used in Flow cytometry/Cell sorting to evaluate the lymphomacidal and immunomodulatory activities of a protein fraction isolated from fermented wheat germ.
Fri Feb 23 00:00:00 EST 2018
Long-peptide vaccination with driver gene mutations in p53 and Kras induces cancer mutation-specific effector as well as regulatory T cell responses.
Oncoimmunology
Quandt J,Schlude C,Bartoschek M,Will R,Cid-Arregui A,Schölch S,Reissfelder C,Weitz J,Schneider M,Wiemann S,Momburg F,Beckhove P
12-8898 was used in Flow cytometry/Cell sorting to study the immunotherapeutic potential of a panel of long peptides comprising driver gene mutations in TP35 and KRAS frequently found in gastrointestinal tumours.
Tue Jan 12 00:00:00 EST 2021
A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product.
Cell metabolism
Liberti MV,Dai Z,Wardell SE,Baccile JA,Liu X,Gao X,Baldi R,Mehrmohamadi M,Johnson MO,Madhukar NS,Shestov AA,Chio IIC,Elemento O,Rathmell JC,Schroeder FC,McDonnell DP,Locasale JW
12-8898 was used in Flow cytometry/Cell sorting to develop a predictive model for selective targeting of the Warburg effect.
Tue Oct 03 00:00:00 EDT 2017
Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation.
Science translational medicine
Allen E,Jabouille A,Rivera LB,Lodewijckx I,Missiaen R,Steri V,Feyen K,Tawney J,Hanahan D,Michael IP,Bergers G
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Wed Apr 12 00:00:00 EDT 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
12-8898 was used in Flow cytometry/Cell sorting to define a fundamental function of Egr2 and Egr3, operating as a checkpoint controlling the transition between clonal expansion and differentiation of effector T cells.
Mon Jun 05 00:00:00 EDT 2017
1810011o10 Rik Inhibits the Antitumor Effect of Intratumoral CD8+ T Cells through Suppression of Notch2 Pathway in a Murine Hepatocellular Carcinoma Model.
Frontiers in immunology
Dai K,Huang L,Huang YB,Chen ZB,Yang LH,Jiang YA
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Wed Nov 20 00:00:00 EST 2019
A role for the histone H2A deubiquitinase MYSM1 in maintenance of CD8+ T cells.
Immunology
Förster M,Boora RK,Petrov JC,Fodil N,Albanese I,Kim J,Gros P,Nijnik A
12-8898 was used in Flow cytometry/Cell sorting to investigate the role of MYSM1 in T-cell development.
Mon May 01 00:00:00 EDT 2017
NFATc1 controls the cytotoxicity of CD8+ T cells.
Nature communications
Klein-Hessling S,Muhammad K,Klein M,Pusch T,Rudolf R,Flöter J,Qureischi M,Beilhack A,Vaeth M,Kummerow C,Backes C,Schoppmeyer R,Hahn U,Hoth M,Bopp T,Berberich-Siebelt F,Patra A,Avots A,Müller N,Schulze A,Serfling E
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Mon Sep 11 00:00:00 EDT 2017
Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis.
Nature communications
Krzywinska E,Kantari-Mimoun C,Kerdiles Y,Sobecki M,Isagawa T,Gotthardt D,Castells M,Haubold J,Millien C,Viel T,Tavitian B,Takeda N,Fandrey J,Vivier E,Sexl V,Stockmann C
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Fri Nov 17 00:00:00 EST 2017
Armored CAR T cells enhance antitumor efficacy and overcome the tumor microenvironment.
Scientific reports
Yeku OO,Purdon TJ,Koneru M,Spriggs D,Brentjens RJ
12-8898 was used in Flow cytometry/Cell sorting to develop an armoured chimeric antigen receptor T cell capable of constitutive secretion of IL-12, and delineate the mechanism by which these cells overcome a hostile tumour microenvironment.
Tue Sep 05 00:00:00 EDT 2017
Radiation enhanced the local and distant anti-tumor efficacy in dual immune checkpoint blockade therapy in osteosarcoma.
PloS one
Takahashi Y,Yasui T,Tamari K,Minami K,Otani K,Isohashi F,Seo Y,Kambe R,Koizumi M,Ogawa K
Mon Jan 08 00:00:00 EST 2018
Expression of inhibitory receptors and polyfunctional responses of T cells are linked to the risk of congenital transmission of T. cruzi.
PLoS neglected tropical diseases
Egui A,Lasso P,Thomas MC,Carrilero B,González JM,Cuéllar A,Segovia M,Puerta CJ,López MC
12-8898 was used in Flow cytometry/Cell sorting to suggest that the maternal immune profile of the CD4+ and CD8+ T cells could be a determining factor in the congenital transmission of T. cruzi.
Thu Jun 01 00:00:00 EDT 2017
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.
Cell
Clever D,Roychoudhuri R,Constantinides MG,Askenase MH,Sukumar M,Klebanoff CA,Eil RL,Hickman HD,Yu Z,Pan JH,Palmer DC,Phan AT,Goulding J,Gattinoni L,Goldrath AW,Belkaid Y,Restifo NP
12-8898 was used in Flow cytometry/Cell sorting to find that T-cell-intrinsic expression of the oxygen-sensing prolyl-hydroxylase proteins is required to maintain local tolerance against innocuous antigens in the lung but powerfully licenses colonization by circulating tumor cells.
Thu Aug 25 00:00:00 EDT 2016
The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomas.
Oncoimmunology
Sonner JK,Deumelandt K,Ott M,Thomé CM,Rauschenbach KJ,Schulz S,Munteanu B,Mohapatra S,Adam I,Hofer AC,Feuerer M,Opitz CA,Hopf C,Wick W,Platten M
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation.
Nature communications
Bulla R,Tripodo C,Rami D,Ling GS,Agostinis C,Guarnotta C,Zorzet S,Durigutto P,Botto M,Tedesco F
12889882 was used in flow cytometry to suggest that locally synthesized C1q promotes tumor growth
Mon Feb 01 00:00:00 EST 2016
Dendritic cell function and pathogen-specific T cell immunity are inhibited in mice administered levonorgestrel prior to intranasal Chlamydia trachomatis infection.
Scientific reports
Quispe Calla NE,Vicetti Miguel RD,Mei A,Fan S,Gilmore JR,Cherpes TL
12-8898 was used in Flow cytometry/Cell sorting to demonstrate that levonorgestrel suppresses dendritic cell activation and function, and inhibits formation of pathogen-specific T-cell immunity.
Mon Nov 28 00:00:00 EST 2016
Caribbean and La Réunion Chikungunya Virus Isolates Differ in Their Capacity To Induce Proinflammatory Th1 and NK Cell Responses and Acute Joint Pathology.
Journal of virology
Teo TH,Her Z,Tan JJ,Lum FM,Lee WW,Chan YH,Ong RY,Kam YW,Leparc-Goffart I,Gallian P,Rénia L,de Lamballerie X,Ng LF
12-8898 was used in Flow cytometry/Cell sorting to demonstrate that the Caribbean CHIKV isolate has an enfeebled replication and induces a less pathogenic response in the mammalian host.
Sat Aug 01 00:00:00 EDT 2015
Amphiregulin activates regulatory T lymphocytes and suppresses CD8+ T cell-mediated anti-tumor response in hepatocellular carcinoma cells.
Oncotarget
Yuan CH,Sun XM,Zhu CL,Liu SP,Wu L,Chen H,Feng MH,Wu K,Wang FB
12-8898 was used in Flow cytometry/Cell sorting to investigate how hepatocellular carcinoma cells alter endogenous anti-tumor immunity and their related signaling pathways.
Tue Oct 13 00:00:00 EDT 2015
The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals.
Nature immunology
Salmond RJ,Brownlie RJ,Morrison VL,Zamoyska R
12-8898 was used in Flow cytometry/Cell sorting to study how loss-of-function PTPN22 alleles can lead to the population expansion of effector and/or memory T cells and a predisposition to human autoimmunity.
Mon Sep 01 00:00:00 EDT 2014
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.
Nature communications
Chen L,Gibbons DL,Goswami S,Cortez MA,Ahn YH,Byers LA,Zhang X,Yi X,Dwyer D,Lin W,Diao L,Wang J,Roybal J,Patel M,Ungewiss C,Peng D,Antonia S,Mediavilla-Varela M,Robertson G,Suraokar M,Welsh JW,Erez B,Wistuba II,Chen L,Peng D,Wang S,Ullrich SE,Heymach JV,Kurie JM,Qin FX
12-8898 was used in Flow cytometry/Cell sorting to reveal a link between EMT and T-cell dysfunction and show that ZEB1 promotes metastasis through a cell non-autonomous mechanism.
Tue Oct 28 00:00:00 EDT 2014
Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock.
PloS one
Hou H,Liu W,Wu S,Lu Y,Peng J,Zhu Y,Lu Y,Wang F,Sun Z
Published figure using Granzyme B monoclonal antibody (Product # 12-8898-82) in Flow Cytometry
Mon Jul 06 00:00:00 EDT 2015
Killer cell lectin-like receptor G1 deficiency significantly enhances survival after Mycobacterium tuberculosis infection.
Infection and immunity
Cyktor JC,Carruthers B,Stromberg P,Flaño E,Pircher H,Turner J
12-8898 was used in Flow cytometry/Cell sorting to investigate the requirement of the T cell differentiation marker KLRG1 during M. tuberculosis infection, showing that deficiency significantly enhances survival.
Mon Apr 01 00:00:00 EDT 2013
