Product References
Sphingomyelin Synthase 2 Inhibition Ameliorates Cerebral Ischemic Reperfusion Injury Through Reducing the Recruitment of Toll-Like Receptor 4 to Lipid Rafts.
Journal of the American Heart Association
Xue J,Yu Y,Zhang X,Zhang C,Zhao Y,Liu B,Zhang L,Wang L,Chen R,Gao X,Jiao P,Song G,Jiang XC,Qin S
12-9924 was used in Flow cytometry/Cell sorting to investigate the role of SMS2 in a mouse model of cerebral I/R.
Tue Nov 19 00:00:00 EST 2019
Chanzyme TRPM7 Mediates the Ca2+ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation.
Immunity
Schappe MS,Szteyn K,Stremska ME,Mendu SK,Downs TK,Seegren PV,Mahoney MA,Dixit S,Krupa JK,Stipes EJ,Rogers JS,Adamson SE,Leitinger N,Desai BN
Published figure using TLR4/MD-2 Complex monoclonal antibody (Product # 12-9924-82) in Flow Cytometry
Tue Jan 16 00:00:00 EST 2018
IL-33/ST2 signalling and crosstalk with FcεRI and TLR4 is targeted by the parasitic worm product, ES-62.
Scientific reports
Ball DH,Al-Riyami L,Harnett W,Harnett MM
12-9924 was used in Flow cytometry/Cell sorting to investigate whether ES62 targets the MyD88-IL-33 signalling network by subverting ST2-signalling to exhibit therapeutic potential in allergy.
Wed Mar 14 00:00:00 EDT 2018
TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK.
The Journal of experimental medicine
Schweighoffer E,Nys J,Vanes L,Smithers N,Tybulewicz VLJ
12-9924 was used in Flow cytometry/Cell sorting to demonstrate two distinct signalling pathways for TLR4, one via the BCR and the other through MYD88.
Mon May 01 00:00:00 EDT 2017
Green Tea Polyphenol Epigallocatechin-3-gallate Suppresses Toll-like Receptor 4 Expression via Up-regulation of E3 Ubiquitin-protein Ligase RNF216.
The Journal of biological chemistry
Kumazoe M,Nakamura Y,Yamashita M,Suzuki T,Takamatsu K,Huang Y,Bae J,Yamashita S,Murata M,Yamada S,Shinoda Y,Yamaguchi W,Toyoda Y,Tachibana H
12-9924 was used in Flow cytometry/Cell sorting to understand the anti-inflammatory mechanisms of the green tea polyphenol epigallocatechin-3-gallate.
Fri Mar 10 00:00:00 EST 2017
Green Tea Polyphenol Epigallocatechin-3-gallate Suppresses Toll-like Receptor 4 Expression via Up-regulation of E3 Ubiquitin-protein Ligase RNF216.
The Journal of biological chemistry
Kumazoe M,Nakamura Y,Yamashita M,Suzuki T,Takamatsu K,Huang Y,Bae J,Yamashita S,Murata M,Yamada S,Shinoda Y,Yamaguchi W,Toyoda Y,Tachibana H
12-9924 was used in Flow cytometry/Cell sorting to understand the anti-inflammatory mechanisms of the green tea polyphenol epigallocatechin-3-gallate.
Fri Mar 10 00:00:00 EST 2017
Deficiency of the TLR4 analogue RP105 aggravates vein graft disease by inducing a pro-inflammatory response.
Scientific reports
Wezel A,de Vries MR,Maassen JM,Kip P,Peters EA,Karper JC,Kuiper J,Bot I,Quax PHA
12-9924 was used in Flow cytometry/Cell sorting to determine aggravated vein graft disease caused by RP105 deficiency results from an increased local inflammatory response.
Thu Apr 07 00:00:00 EDT 2016
Porphyromonas gingivalis gingipains selectively reduce CD14 expression, leading to macrophage hyporesponsiveness to bacterial infection.
Journal of innate immunity
Wilensky A,Tzach-Nahman R,Potempa J,Shapira L,Nussbaum G
12-9924 was used in Flow cytometry/Cell sorting to study how porphyromonas gingivalis gingipains can reduce CD14 expression without affecting expression of the bacterial-sensing TLRs.
Mon Dec 21 00:00:00 EST 2015
Inefficient TLR4/MD-2 heterotetramerization by monophosphoryl lipid A.
PloS one
Casella CR,Mitchell TC
Published figure using TLR4/MD-2 Complex monoclonal antibody (Product # 12-9924-82) in Flow Cytometry
Mon Nov 11 00:00:00 EST 2013
Inefficient TLR4/MD-2 heterotetramerization by monophosphoryl lipid A.
PloS one
Casella CR,Mitchell TC
Published figure using TLR4/MD-2 Complex monoclonal antibody (Product # 12-9924-82) in Flow Cytometry
Mon Nov 11 00:00:00 EST 2013
Defective antiviral responses of induced pluripotent stem cells to baculoviral vector transduction.
Journal of virology
Chen GY,Hwang SM,Su HJ,Kuo CY,Luo WY,Lo KW,Huang CC,Chen CL,Yu SH,Hu YC
12-9924 was used in Flow cytometry/Cell sorting to confirm that iPSCs responded poorly to baculovirus due to the impaired sensing and signaling system.
Wed Aug 01 00:00:00 EDT 2012
Glycyrrhizin and isoliquiritigenin suppress the LPS sensor toll-like receptor 4/MD-2 complex signaling in a different manner.
Journal of leukocyte biology
Honda H,Nagai Y,Matsunaga T,Saitoh S,Akashi-Takamura S,Hayashi H,Fujii I,Miyake K,Muraguchi A,Takatsu K
12-9924 was used in Flow cytometry/Cell sorting to demonstrate that GL and ILG suppress different steps of the lipopolysaccharide sensor TLR4/MD-2 complex signalling at the receptor level.
Fri Jun 01 00:00:00 EDT 2012
High susceptibility to lipopolysaccharide-induced lethal shock in encephalomyocarditis virus-infected mice.
Scientific reports
Ohtaki H,Ito H,Hoshi M,Osawa Y,Takamatsu M,Hara A,Ishikawa T,Moriwaki H,Saito K,Seishima M
12-9924 was used in Flow cytometry/Cell sorting to examine and explore the effect of lipopolysaccharide on encephalomyocarditis virus-infected mice.
Fri Apr 12 00:00:00 EDT 2013
Mechanisms by which chronic ethanol feeding limits the ability of dendritic cells to stimulate T-cell proliferation.
Alcoholism, clinical and experimental research
Fan J,Edsen-Moore MR,Turner LE,Cook RT,Legge KL,Waldschmidt TJ,Schlueter AJ
12-9924 was used in Flow cytometry/Cell sorting to assess the functional capability of ethanol-exposed dendritic cells, using a murine model of chronic alcohol abuse.
Sat Jan 01 00:00:00 EST 2011
Overexpression of sICAM-1 in the alveolar epithelial space results in an exaggerated inflammatory response and early death in Gram negative pneumonia.
Respiratory research
Mendez MP,Monroy YK,Du M,Preston AM,Tolle L,Lin Y,VanDussen KL,Samuelson LC,Standiford TJ,Curtis JL,Beck JM,Christensen PJ,Paine R
12-9924 was used in Flow cytometry/Cell sorting to conclude that alveolar sICAM-1 modulates pulmonary inflammation.
Wed Jan 19 00:00:00 EST 2011
The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut.
Immunity
Suzuki K,Maruya M,Kawamoto S,Sitnik K,Kitamura H,Agace WW,Fagarasan S
12-9924 was used in Flow cytometry/Cell sorting to investigate whether follicular dendritic cells within the germinal centers directly contribute to the IgA production in Peyer's patches, showing that sensing of environmental stimuli promotes IgA production.
Fri Jul 23 00:00:00 EDT 2010
C-type lectin SIGN-R1 has a role in experimental colitis and responsiveness to lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950)
Saunders SP,Barlow JL,Walsh CM,Bellsoi A,Smith P,McKenzie AN,Fallon PG
12-9924 was used in Flow cytometry/Cell sorting to illustrate that specific intracellular adhesion molecule-3 grabbing nonintegrin homolog-related 1 (SIGN-R1) is an important innate factor in response to LPS.
Mon Mar 01 00:00:00 EST 2010
17Beta-estradiol promotes TLR4-triggered proinflammatory mediator production through direct estrogen receptor alpha signaling in macrophages in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Calippe B,Douin-Echinard V,Delpy L,Laffargue M,Lélu K,Krust A,Pipy B,Bayard F,Arnal JF,Guéry JC,Gourdy P
12-9924 was used in Flow cytometry/Cell sorting to investigate the effect of 17β-estradiol on macrophage effector functions under inflammatory conditions in vivo.
Thu Jul 15 00:00:00 EDT 2010
Toll-like receptor 2 mediates proliferation, survival, NF-kappaB translocation, and cytokine mRNA expression in LIF-maintained mouse embryonic stem cells.
Stem cells and development
Taylor T,Kim YJ,Ou X,Derbigny W,Broxmeyer HE
12-9924 was used in Flow cytometry/Cell sorting to identify toll-like receptor 2 as present and functional in E14, R1, and CGR8 murine embryonic stem cell lines.
Wed Sep 01 00:00:00 EDT 2010
A role for cFLIP in B cell proliferation and stress MAPK regulation.
Journal of immunology (Baltimore, Md. : 1950)
Zhang H,Rosenberg S,Coffey FJ,He YW,Manser T,Hardy RR,Zhang J
12-9924 was used in Flow cytometry/Cell sorting to reveal the novel functions of cFLIP in B cells.
Thu Jan 01 00:00:00 EST 2009
Estrogens augment cell surface TLR4 expression on murine macrophages and regulate sepsis susceptibility in vivo.
Endocrinology
Rettew JA,Huet YM,Marriott I
12-9924 was used in Flow cytometry/Cell sorting to provide a potential mechanism underlying the immunoenhancing effects of estrogens.
Sat Aug 01 00:00:00 EDT 2009
Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut.
Immunity
Tsuji M,Suzuki K,Kitamura H,Maruya M,Kinoshita K,Ivanov II,Itoh K,Littman DR,Fagarasan S
12-9924 was used in Flow cytometry/Cell sorting to investigate the sites and mechanisms for T cell-independent IgA synthesis.
Fri Aug 15 00:00:00 EDT 2008
Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids.
Atherosclerosis
Liu X,Ukai T,Yumoto H,Davey M,Goswami S,Gibson FC,Genco CA
12-9924 was used in Flow cytometry/Cell sorting to demonstrate that TLR2 plays a critical role in the progression of atherosclerosis in Apoe-/- mice.
Tue Jan 01 00:00:00 EST 2008
Testosterone reduces macrophage expression in the mouse of toll-like receptor 4, a trigger for inflammation and innate immunity.
Biology of reproduction
Rettew JA,Huet-Hudson YM,Marriott I
12-9924 was used in Flow cytometry/Cell sorting to report that orchidectomized mice were significantly more susceptible to endotoxic shock and have higher TLR4 expression than sham gonadectomized mice.
Sat Mar 01 00:00:00 EST 2008
Macrophage-elicited osteoclastogenesis in response to bacterial stimulation requires Toll-like receptor 2-dependent tumor necrosis factor-alpha production.
Infection and immunity
Ukai T,Yumoto H,Gibson FC,Genco CA
12-9924 was used in Flow cytometry/Cell sorting to define a requirement for TLR2 in TNF-alpha-elicited osteoclastogenesis in response to exposure to P. gingivalis.
Fri Feb 01 00:00:00 EST 2008
Gangliosides trigger inflammatory responses via TLR4 in brain glia.
The American journal of pathology
Jou I,Lee JH,Park SY,Yoon HJ,Joe EH,Park EJ
12-9924 was used in Flow cytometry/Cell sorting to suggest that TLR4 may provide an explanation for the pathological ability of gangliosides to cause inflammatory conditions in the brain.
Mon May 01 00:00:00 EDT 2006
TLRs regulate the gatekeeping functions of the intestinal follicle-associated epithelium.
Journal of immunology (Baltimore, Md. : 1950)
Chabot S,Wagner JS,Farrant S,Neutra MR
Sat Apr 01 00:00:00 EST 2006
Platelets express functional Toll-like receptor-4.
Blood
Andonegui G,Kerfoot SM,McNagny K,Ebbert KV,Patel KD,Kubes P
12-9924 was used in Flow cytometry/Cell sorting to study platelets expressing functional levels of TLR4, which contribute to thrombocytopenia through neutrophil-dependent pulmonary sequestration in response to LPS.
Sat Oct 01 00:00:00 EDT 2005
Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression.
Journal of leukocyte biology
Boehmer ED,Goral J,Faunce DE,Kovacs EJ
12-9924 was used in Western Blotting to suggest that decreased MAPK expression could be a mechanism responsible for age-related deterioration of the immune system.
Sun Feb 01 00:00:00 EST 2004
TGF-beta1 treated murine dendritic cells are maturation resistant and down-regulate Toll-like receptor 4 expression.
Journal of Zhejiang University. Science
Mou HB,Lin MF,Cen H,Yu J,Meng XJ
12-9924 was used in Flow cytometry/Cell sorting to explore the effects of transforming growth factor β1 on dendritic cells.
Fri Oct 01 00:00:00 EDT 2004
Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors.
The Journal of biological chemistry
Nishiya T,DeFranco AL
12-9924 was used in Flow cytometry/Cell sorting to study how the functions of TLRs are diversified not only in their extracellular regions for ligand recognition but also in their transmembrane and cytoplasmic regions for subcellular localization and signaling properties.
Fri Apr 30 00:00:00 EDT 2004