Product References
Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4/MyD88/NF-κB pathway in LPC-induced demyelination.
Journal of neuroinflammation
Wang Y,Sadike D,Huang B,Li P,Wu Q,Jiang N,Fang Y,Song G,Xu L,Wang W,Xie M
14-0032-82 was used in Immunohistochemistry to investigate the roles of Tregs in pyroptosis and their involvement in lysophosphatidylcholine-induced demyelination.
Sat Feb 18 00:00:00 EST 2023
The activity of the aryl hydrocarbon receptor in T cells tunes the gut microenvironment to sustain autoimmunity and neuroinflammation.
PLoS biology
Merchak AR,Cahill HJ,Brown LC,Brown RM,Rivet-Noor C,Beiter RM,Slogar ER,Olgun DG,Gaultier A
14-0032-82 was used in Flow Cytometry, Functional Assay, Immunocytochemistry, Immunohistochemistry (Frozen) to demonstrate a newly emerging role for AHR in mediating the interdependence between T lymphocytes and the microbiota, while simultaneously identifying new potential molecular targets for the treatment of MS and other autoimmune diseases.
Wed Feb 01 00:00:00 EST 2023
The activity of the aryl hydrocarbon receptor in T cells tunes the gut microenvironment to sustain autoimmunity and neuroinflammation.
PLoS biology
Merchak AR,Cahill HJ,Brown LC,Brown RM,Rivet-Noor C,Beiter RM,Slogar ER,Olgun DG,Gaultier A
14-0032-82 was used in Flow Cytometry, Functional Assay, Immunocytochemistry, Immunohistochemistry (Frozen) to demonstrate a newly emerging role for AHR in mediating the interdependence between T lymphocytes and the microbiota, while simultaneously identifying new potential molecular targets for the treatment of MS and other autoimmune diseases.
Wed Feb 01 00:00:00 EST 2023
Exosomes from Ub‑HBcAg‑overexpressing dendritic cells induce T‑lymphocyte differentiation and enhance cytotoxic T‑lymphocyte activity.
Experimental and therapeutic medicine
Yang Y,Liu K,Zhou W,Dai S
14-0032-82 was used in In vitro Assay to suggest the potential of Dexs-Ub-HBcAg for development as a future therapeutic option for the elimination of HBV.
Sat Apr 01 00:00:00 EDT 2023
A single-cell atlas reveals the heterogeneity of meningeal immunity in a mouse model of Methyl CpG binding protein 2 deficiency.
Frontiers in immunology
Li H,Hu M,Huang Z,Wang Y,Xu Y,Deng J,Zhu M,Feng W,Xu X
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Immunohistochemistry
Tue Jan 31 00:00:00 EST 2023
LncRNA ANRIL-mediated miR-181b-5p/S1PR1 axis is involved in the progression of uremic cardiomyopathy through activating T cells.
Scientific reports
Xu Y,Cao L,Ji S,Shen W
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Thu Oct 27 00:00:00 EDT 2022
Estrogen Protects against Renal Ischemia-Reperfusion Injury by Regulating Th17/Treg Cell Immune Balance.
Disease markers
Zhang Y,Chang Y,Han Z,Ma K,Zeng X,Li L
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Tue Oct 18 00:00:00 EDT 2022
Therapeutic CFTR Correction Normalizes Systemic and Lung-Specific S1P Level Alterations Associated with Heart Failure.
International journal of molecular sciences
Uhl FE,Vanherle L,Matthes F,Meissner A
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Fri Jan 14 00:00:00 EST 2022
Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling.
The Journal of biological chemistry
Yan Q,Gao H,Yao Q,Ling K,Xiao G
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2022
Precise delivery of doxorubicin and imiquimod through pH-responsive tumor microenvironment-active targeting micelles for chemo- and immunotherapy.
Materials today. Bio
Wen YH,Hsieh PI,Chiu HC,Chiang CW,Lo CL,Chiang YT
14-0032-82 was used in Immunohistochemistry-paraffin-immunofluorescence to show that these micelles exhibit precise pH responsiveness and ideal drug delivery capabilities for combined chemo- and immunotherapy; these results significantly contribute to the future development of nanomedicines in cancer therapy.
Thu Dec 15 00:00:00 EST 2022
Targeted clearance of p21- but not p16-positive senescent cells prevents radiation-induced osteoporosis and increased marrow adiposity.
Aging cell
Chandra A,Lagnado AB,Farr JN,Doolittle M,Tchkonia T,Kirkland JL,LeBrasseur NK,Robbins PD,Niedernhofer LJ,Ikeno Y,Passos JF,Monroe DG,Pignolo RJ,Khosla S
14-0032-82 was used in Immunohistochemistry-immunofluorescence to demonstrate that radiation-induced osteoporosis is driven predominantly by p21Cip1 - rather than p16Ink4a -mediated cellular senescence.
Sun May 01 00:00:00 EDT 2022
Choroid plexus-selective inactivation of adenosine A2A receptors protects against T cell infiltration and experimental autoimmune encephalomyelitis.
Journal of neuroinflammation
Zheng W,Feng Y,Zeng Z,Ye M,Wang M,Liu X,Tang P,Shang H,Sun X,Lin X,Wang M,Li Z,Weng Y,Guo W,Vakal S,Chen JF
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Fri Feb 18 00:00:00 EST 2022
PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells.
Nature communications
Li Q,Zhang L,You W,Xu J,Dai J,Hua D,Zhang R,Yao F,Zhou S,Huang W,Dai Y,Zhang Y,Baheti T,Qian X,Pu L,Xu J,Xia Y,Zhang C,Tang J,Wang X
14-0032-82 was used in Flow Cytometry, Functional Assay, Immunocytochemistry, Immunohistochemistry (Frozen) to demonstrate that the PRDM1-USP22-SPI1 axis regulates PD-L1 levels, resulting in infiltrated CD8+ T cell exhaustion.
Mon Dec 12 00:00:00 EST 2022
JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction.
Cell reports
Vogel A,Martin K,Soukup K,Halfmann A,Kerndl M,Brunner JS,Hofmann M,Oberbichler L,Korosec A,Kuttke M,Datler H,Kieler M,Musiejovsky L,Dohnal A,Sharif O,Schabbauer G
14-0032-82 was used in Immunohistochemistry to conclude that DC-intrinsic JAK1 promotes peripheral tolerance, suggesting potential unwarranted DC-mediated effects of Jakinibs in autoimmune diseases.
Tue Feb 22 00:00:00 EST 2022
Malaria parasite heme biosynthesis promotes and griseofulvin protects against cerebral malaria in mice.
Nature communications
Chandana M,Anand A,Ghosh S,Das R,Beura S,Jena S,Suryawanshi AR,Padmanaban G,Nagaraj VA
14-0032-82 was used in Immunohistochemistry-immunofluorescence to show heme synthesized in asexual stages promotes cerebral pathogenesis by enhancing hemozoin formation.
Tue Jul 12 00:00:00 EDT 2022
Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies.
The Journal of experimental medicine
Heindl S,Ricci A,Carofiglio O,Zhou Q,Arzberger T,Lenart N,Franzmeier N,Hortobagyi T,Nelson PT,Stowe AM,Denes A,Edbauer D,Liesz A
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Mon Aug 02 00:00:00 EDT 2021
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Mon Jul 05 00:00:00 EDT 2021
Intracellular aggregation of peptide-reprogrammed small molecule nanoassemblies enhances cancer chemotherapy and combinatorial immunotherapy.
Acta pharmaceutica Sinica. B
Peng J,Xiao Y,Yang Q,Liu Q,Chen Y,Shi K,Hao Y,Han R,Qian Z
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2021
PD-L1 overexpression conveys tolerance of mesenchymal stem cell-derived cardiomyocyte-like cells in an allogeneic mouse model.
Journal of cellular physiology
Mardomi A,Limoni SK,Rahbarghazi R,Mohammadi N,Khorashadizadeh M,Ranjbaran H,Nataj HH,Jafari N,Hasani B,Abediankenari S
14-0032-82 was used in Immunohistochemistry to verify the potential of PD-L1 overexpression as a preparative strategy for the protection of allogeneic MSCs-derived CLCs against the detrimental alloreaction.© 2021 Wiley Periodicals LLC.
Wed Sep 01 00:00:00 EDT 2021
Eliminating mesothelioma by AAV-vectored, PD1-based vaccination in the tumor microenvironment.
Molecular therapy oncolytics
Tan Z,Chiu MS,Yan CW,Man K,Chen Z
14-0032-82 was used in Flow Cytometry to evaluate the potential of recombinant adeno-associated virus (rAAV)-vectored, PD1-based vaccination in the tumor microenvironment (TME) to activate antigen-specific T cell responses in the immune-competent murine mesothelioma model.
Fri Mar 26 00:00:00 EDT 2021
ERAP1 Controls the Autoimmune Response against Melanocytes in Psoriasis by Generating the Melanocyte Autoantigen and Regulating Its Amount for HLA-C*06:02 Presentation.
Journal of immunology (Baltimore, Md. : 1950)
Arakawa A,Reeves E,Vollmer S,Arakawa Y,He M,Galinski A,Stöhr J,Dornmair K,James E,Prinz JC
14-0032-82 was used in Flow cytometry/Cell sorting to demonstrate that in psoriasis, ERAP1 generates the causative melanocyte autoantigen through trimming N-terminal elongated peptide precursors to the appropriate length for presentation by HLA-C*06:02.
Mon Nov 01 00:00:00 EDT 2021
Early inflammation precedes cardiac fibrosis and heart failure in desmoglein 2 murine model of arrhythmogenic cardiomyopathy.
Cell and tissue research
Ng KE,Delaney PJ,Thenet D,Murtough S,Webb CM,Zaman N,Tsisanova E,Mastroianni G,Walker SLM,Westaby JD,Pennington DJ,Pink R,Kelsell DP,Tinker A
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Fri Oct 01 00:00:00 EDT 2021
Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells.
Oncology letters
Chen J,Ding Y,Huang F,Lan R,Wang Z,Huang W,Chen R,Wu B,Fu L,Yang Y,Liu J,Hong J,Zhang W,Zhang L
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Neuroimmune Consequences of eIF4E Phosphorylation on Chemotherapy-Induced Peripheral Neuropathy.
Frontiers in immunology
Agalave NM,Mody PH,Szabo-Pardi TA,Jeong HS,Burton MD
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Mon Sep 20 00:00:00 EDT 2021
Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer Model.
Vaccines
Trofimova O,Korotkaja K,Skrastina D,Jansons J,Spunde K,Isaguliants M,Zajakina A
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Wed Oct 27 00:00:00 EDT 2021
Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression.
Clinical and translational medicine
Cheng CS,Tan HY,Wang N,Chen L,Meng Z,Chen Z,Feng Y
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Immunohistochemistry (Paraffin)
Tue Jun 01 00:00:00 EDT 2021
Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression.
Clinical and translational medicine
Cheng CS,Tan HY,Wang N,Chen L,Meng Z,Chen Z,Feng Y
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Immunohistochemistry (Paraffin)
Tue Jun 01 00:00:00 EDT 2021
Molecular Mechanisms Underpinning the Circulation and Cellular Uptake of Mycobacterium ulcerans Toxin Mycolactone.
Frontiers in pharmacology
Tello Rubio B,Bugault F,Baudon B,Raynal B,Brûlé S,Morel JD,Saint-Auret S,Blanchard N,Demangel C,Guenin-Macé L
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Tue Oct 05 00:00:00 EDT 2021
Expression of CCRL2 Inhibits Tumor Growth by Concentrating Chemerin and Inhibiting Neoangiogenesis.
Cancers
Al Delbany D,Robert V,Dubois-Vedrenne I,Del Prete A,Vernimmen M,Radi A,Lefort A,Libert F,Wittamer V,Sozzani S,Parmentier M
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Immunohistochemistry
Tue Oct 05 00:00:00 EDT 2021
Small Molecule Potentiator of Adjuvant Activity Enhancing Survival to Influenza Viral Challenge.
Frontiers in immunology
Saito T,Sako Y,Sato-Kaneko F,Hosoya T,Yao S,Lao FS,Shpigelman J,Messer K,Pu M,Shukla NM,Chan M,Chu PJ,Cottam HB,Hayashi T,Carson DA,Corr M
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Fri Dec 10 00:00:00 EST 2021
Gut Microbiota Dysbiosis Induced by Intracerebral Hemorrhage Aggravates Neuroinflammation in Mice.
Frontiers in microbiology
Yu X,Zhou G,Shao B,Zhou H,Xu C,Yan F,Wang L,Chen G,Li J,Fu X
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Wed May 26 00:00:00 EDT 2021
Type 1 Cytotoxic T Cells Increase in Placenta after Intrauterine Inflammation.
Frontiers in immunology
Liu J,Liu Y,Panda S,Liu A,Lei J,Burd I
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Fri Dec 17 00:00:00 EST 2021
Soft implantable drug delivery device integrated wirelessly with wearable devices to treat fatal seizures.
Science advances
Joo H,Lee Y,Kim J,Yoo JS,Yoo S,Kim S,Arya AK,Kim S,Choi SH,Lu N,Lee HS,Kim S,Lee ST,Kim DH
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Immunohistochemistry
Fri Jan 01 00:00:00 EST 2021
Soft implantable drug delivery device integrated wirelessly with wearable devices to treat fatal seizures.
Science advances
Joo H,Lee Y,Kim J,Yoo JS,Yoo S,Kim S,Arya AK,Kim S,Choi SH,Lu N,Lee HS,Kim S,Lee ST,Kim DH
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Immunohistochemistry
Fri Jan 01 00:00:00 EST 2021
STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer.
Cellular and molecular gastroenterology and hepatology
Vonderhaar EP,Barnekow NS,McAllister D,McOlash L,Eid MA,Riese MJ,Tarakanova VL,Johnson BD,Dwinell MB
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Mon Jan 24 00:00:00 EST 2022
A mouse model for the study of anti-tumor T cell responses in Kras-driven lung adenocarcinoma.
Cell reports methods
Fitzgerald B,Connolly KA,Cui C,Fagerberg E,Mariuzza DL,Hornick NI,Foster GG,William I,Cheung JF,Joshi NS
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Immunocytochemistry
Mon Sep 27 00:00:00 EDT 2021
Inducible T-Cell Costimulator Mediates Lymphocyte/Macrophage Interactions During Liver Repair.
Frontiers in immunology
Ramavath NN,Gadipudi LL,Provera A,Gigliotti LC,Boggio E,Bozzola C,Albano E,Dianzani U,Sutti S
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Mon Feb 14 00:00:00 EST 2022
STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer.
Journal for immunotherapy of cancer
Lee SJ,Yang H,Kim WR,Lee YS,Lee WS,Kong SJ,Lee HJ,Kim JH,Cheon J,Kang B,Chon HJ,Kim C
14-0032-82 was used in Flow Cytometry to elucidate the immune-evasion mechanisms during the peritoneal carcinomatosis of colon cancer and developed a novel immunotherapy by activating the stimulator of interferon genes (STING) pathway.
Tue Jun 01 00:00:00 EDT 2021
Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells.
Nature
Zhang B,Ma S,Rachmin I,He M,Baral P,Choi S,Gonçalves WA,Shwartz Y,Fast EM,Su Y,Zon LI,Regev A,Buenrostro JD,Cunha TM,Chiu IM,Fisher DE,Hsu YC
14-0032 was used in Immunohistochemistry to report that, in mice, acute stress leads to hair greying through the fast depletion of melanocyte stem cells.
Wed Jan 01 00:00:00 EST 2020
Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer.
Cell research
Wang S,Qu Y,Xia P,Chen Y,Zhu X,Zhang J,Wang G,Tian Y,Ying J,Fan Z
14-0032-82 was used in Flow Cytometry to profile tumor infiltrating innate lymphoid cells in colorectal cancer at early and late stages.
Wed Jul 01 00:00:00 EDT 2020
Dynamic regulation of chromatin organizer SATB1 via TCR-induced alternative promoter switch during T-cell development.
Nucleic acids research
Patta I,Madhok A,Khare S,Gottimukkala KP,Verma A,Giri S,Dandewad V,Seshadri V,Lal G,Misra-Sen J,Galande S
14-0032 was used in Flow cytometry/Cell sorting to study the mechanism regulating expression of SATB1 during T-cell development.
Fri Jun 19 00:00:00 EDT 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
Inhibition of IDO leads to IL-6-dependent systemic inflammation in mice when combined with photodynamic therapy.
Cancer immunology, immunotherapy : CII
Wachowska M,Stachura J,Tonecka K,Fidyt K,Braniewska A,Sas Z,Kotula I,Rygiel TP,Boon L,Golab J,Muchowicz A
14-0032-82 was used in Flow Cytometry to investigate the antitumor potential of photodynamic therapy combined with indoleamine 2,3-dioxygenase 1 inhibitor in the murine 4T1 and E0771 orthotopic breast cancer models.
Mon Jun 01 00:00:00 EDT 2020
Novel enhanced GFP-positive congenic inbred strain establishment and application of tumor-bearing nude mouse model.
Cancer science
Lan Q,Chen Y,Dai C,Li S,Fei X,Dong J,Shen Y,Dai X,Lu Z,Liu B,Wang Q,Wang H,Zhou Z,Ji X,Wang Z,Huang Q
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2020
In Situ Therapeutic Cancer Vaccination with an Oncolytic Virus Expressing Membrane-Tethered IL-2.
Molecular therapy oncolytics
Liu W,Dai E,Liu Z,Ma C,Guo ZS,Bartlett DL
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Fri Jun 26 00:00:00 EDT 2020
Secreted Phospholipase A2 Group X Acts as an Adjuvant for Type 2 Inflammation, Leading to an Allergen-Specific Immune Response in the Lung.
Journal of immunology (Baltimore, Md. : 1950)
Ogden HL,Lai Y,Nolin JD,An D,Frevert CW,Gelb MH,Altemeier WA,Hallstrand TS
14-0032-82 was used in Flow Cytometry to demonstrate that exogenous and endogenous sPLA2s play an important role in peripheral sensitization, resulting in airway responses to inhaled Ags.
Mon Jun 15 00:00:00 EDT 2020
Loss of mural cell-derived laminin aggravates hemorrhagic brain injury.
Journal of neuroinflammation
Gautam J,Xu L,Nirwane A,Nguyen B,Yao Y
14-0032-82 was used in Immunohistochemistry-immunofluorescence to suggest that mural cell-derived laminin attenuates blood-brain barrier (BBB) damage in intracerebral hemorrhage (ICH) via decreasing caveolin-1 and thus transcytosis, regulates brain water homeostasis, and plays a beneficial role in ICH.
Mon Apr 06 00:00:00 EDT 2020
Loss of mural cell-derived laminin aggravates hemorrhagic brain injury.
Journal of neuroinflammation
Gautam J,Xu L,Nirwane A,Nguyen B,Yao Y
14-0032-82 was used in Immunohistochemistry-immunofluorescence to suggest that mural cell-derived laminin attenuates blood-brain barrier (BBB) damage in intracerebral hemorrhage (ICH) via decreasing caveolin-1 and thus transcytosis, regulates brain water homeostasis, and plays a beneficial role in ICH.
Mon Apr 06 00:00:00 EDT 2020
Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.
JCI insight
Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Thu Aug 20 00:00:00 EDT 2020
Stroma remodeling and reduced cell division define durable response to PD-1 blockade in melanoma.
Nature communications
Galvani E,Mundra PA,Valpione S,Garcia-Martinez P,Smith M,Greenall J,Thakur R,Helmink B,Andrews MC,Boon L,Chester C,Gremel G,Hogan K,Mandal A,Zeng K,Banyard A,Ashton G,Cook M,Lorigan P,Wargo JA,Dhomen N,Marais R
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Immunohistochemistry (Frozen)
Wed Feb 12 00:00:00 EST 2020
Triptolide Attenuates Transplant Vasculopathy Through Multiple Pathways.
Frontiers in immunology
Luo Z,Liao T,Zhang Y,Zheng H,Sun Q,Han F,Yang Z,Sun Q
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Thu Mar 25 00:00:00 EDT 2021
Antimesothelioma Immunotherapy by CTLA-4 Blockade Depends on Active PD1-Based TWIST1 Vaccination.
Molecular therapy oncolytics
Tan Z,Chiu MS,Yan CW,Wong YC,Huang H,Man K,Chen Z
14-0032-82 was used in Flow Cytometry to demonstrate that TWIST1, the basic helix-loop-helix transcription factor, was associated with human mesothelioma tumorigenesis and is required for the invasion and metastasis of mesothelioma in the immune-competent murine AB1 model.
Fri Mar 27 00:00:00 EDT 2020
Developmental Dysfunction of the Central Nervous System Lymphatics Modulates the Adaptive Neuro-Immune Response in the Perilesional Cortex in a Mouse Model of Traumatic Brain Injury.
Frontiers in immunology
Wojciechowski S,Virenque A,Vihma M,Galbardi B,Rooney EJ,Keuters MH,Antila S,Koistinaho J,Noe FM
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Immunohistochemistry (Frozen)
Wed May 19 00:00:00 EDT 2021
Developmental Dysfunction of the Central Nervous System Lymphatics Modulates the Adaptive Neuro-Immune Response in the Perilesional Cortex in a Mouse Model of Traumatic Brain Injury.
Frontiers in immunology
Wojciechowski S,Virenque A,Vihma M,Galbardi B,Rooney EJ,Keuters MH,Antila S,Koistinaho J,Noe FM
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Immunohistochemistry (Frozen)
Wed May 19 00:00:00 EDT 2021
TH17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity.
Science immunology
Harbour SN,DiToro DF,Witte SJ,Zindl CL,Gao M,Schoeb TR,Jones GW,Jones SA,Hatton RD,Weaver CT
14-0032-82 was used in Immunohistochemistry to find that IL-6 signaling is required for both induction and maintenance of mouse TH17 cells; IL-6Rα-deficient TH17 cells rapidly lost their TH17 phenotype and did not cause disease in two models of colitis.
Fri Jul 17 00:00:00 EDT 2020
Commensal Microbiota Promote Lung Cancer Development via γδ T Cells.
Cell
Jin C,Lagoudas GK,Zhao C,Bullman S,Bhutkar A,Hu B,Ameh S,Sandel D,Liang XS,Mazzilli S,Whary MT,Meyerson M,Germain R,Blainey PC,Fox JG,Jacks T
14-0032-82 was used in Flow Cytometry to link local microbiota-immune crosstalk to lung tumor development and thereby define key cellular and molecular mediators that may serve as effective targets in lung cancer intervention.
Thu Feb 21 00:00:00 EST 2019
Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense.
Cell stem cell
Chen M,Reed RR,Lane AP
14-0032 was used in Immunohistochemistry to establish a mechanism whereby chronic rhinosinusitis inflammation causes a functional switch of neuroepithelial stem cells from regeneration to immune defense.
Thu Oct 03 00:00:00 EDT 2019
Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking.
The Journal of clinical investigation
Zhang J,Supakorndej T,Krambs JR,Rao M,Abou-Ezzi G,Ye RY,Li S,Trinkaus K,Link DC
14-0032 was used in Flow cytometry/Cell sorting to show that HSPC mobilization after cDC ablation is attenuated in mice lacking CXCR2 expression.
Tue Apr 30 00:00:00 EDT 2019
Calnexin Impairs the Antitumor Immunity of CD4+ and CD8+ T Cells.
Cancer immunology research
Chen Y,Ma D,Wang X,Fang J,Liu X,Song J,Li X,Ren X,Li Q,Li Q,Wen S,Luo L,Xia J,Cui J,Zeng G,Chen L,Cheng B,Wang Z
14-0032 was used in Flow cytometry/Cell sorting to demonstrate that T-cell antitumor responses are regulated by calnexin in tumor cells.
Tue Jan 01 00:00:00 EST 2019
Decreased immunoglobulin G in brain regions of elder female APOE4-TR mice accompany with Aβ accumulation.
Immunity & ageing : I & A
Zhang L,Xu J,Gao J,Chen P,Yin M,Zhao W
14-0032-82 was used in Flow Cytometry to determine the alterations of IgG, CD19, and Aβ in various brain regions of uninfected male and female APOE3- and APOE4-TR mice at the age of 3 and 10 months to elucidate impacts of AD risk factors on alterations of brain IgG.
Thu Mar 31 00:00:00 EDT 2022
Regional and functional heterogeneity of antigen presenting cells in the mouse brain and meninges.
Glia
Dando SJ,Kazanis R,Chinnery HR,McMenamin PG
14-0032-82 was used in Immunohistochemistry to demonstrate that systemic inflammation can mature selected microglia populations and choroid plexus/meningeal myeloid cells into functional APCs, which may contribute to the pathogenesis of neuroinflammation and neurodegenerative diseases.
Wed May 01 00:00:00 EDT 2019
Deletion of C-C Motif Chemokine Ligand 5 Worsens Invariant Natural Killer T-Cell-Mediated Hepatitis via Compensatory Up-regulation of CXCR2-Related Chemokine Activity.
Cellular and molecular gastroenterology and hepatology
Chen L,Gu J,Qian Y,Li M,Qian Y,Xu M,Li J,Wen Y,Xia L,Li J,Xia Q,Kong X,Wu H
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Tue Jun 04 00:00:00 EDT 2019
Blood autophagy defect causes accelerated non-hematopoietic organ aging.
Aging
Fang Y,Zhu L,An N,Jiang G,Qian J,Zhao R,Yuan N,Zhang S,Wang J
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Sun Jul 21 00:00:00 EDT 2019
MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment.
Journal for immunotherapy of cancer
Fang DD,Tang Q,Kong Y,Wang Q,Gu J,Fang X,Zou P,Rong T,Wang J,Yang D,Zhai Y
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Thu Nov 28 00:00:00 EST 2019
Pyruvate kinase M2 is requisite for Th1 and Th17 differentiation.
JCI insight
Kono M,Maeda K,Stocton-Gavanescu I,Pan W,Umeda M,Katsuyama E,Burbano C,Orite SYK,Vukelic M,Tsokos MG,Yoshida N,Tsokos GC
14-0032 was used in Flow cytometry/Cell sorting to demonstrate that CaMK4 binds to PKM2 and promotes its activity, which is requisite for Th1 and Th17 differentiation.
Thu Jun 20 00:00:00 EDT 2019
Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells.
Oncoimmunology
Salerno F,Guislain A,Freen-Van Heeren JJ,Nicolet BP,Young HA,Wolkers MC
14-0032 was used in Flow cytometry/Cell sorting to conclude that post-transcriptional mechanisms could be modulated to potentiate effective T cell therapies in cancer.
Tue Jan 12 00:00:00 EST 2021
Isolating Immune Cells from Mouse Embryonic Skin.
Methods in molecular biology (Clifton, N.J.)
Kurbet AS,Raghavan S
14-0032-82 was used in Flow Cytometry, Functional Assay, Immunocytochemistry, Immunohistochemistry (Frozen) to present a detailed protocol for isolating monocytes, macrophages, and epidermal dendritic T cell populations from embryonic skin.
Mon Jun 03 00:00:00 EDT 2019
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Cell
Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Thu Jun 28 00:00:00 EDT 2018
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Cell
Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Thu Jun 28 00:00:00 EDT 2018
Targeted delivery of immune therapeutics to lymph nodes prolongs cardiac allograft survival.
The Journal of clinical investigation
Bahmani B,Uehara M,Jiang L,Ordikhani F,Banouni N,Ichimura T,Solhjou Z,Furtmüller GJ,Brandacher G,Alvarez D,von Andrian UH,Uchimura K,Xu Q,Vohra I,Yilmam OA,Haik Y,Azzi J,Kasinath V,Bromberg JS,McGrath MM,Abdi R
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Western Blot
Thu Nov 01 00:00:00 EDT 2018
Targeted delivery of immune therapeutics to lymph nodes prolongs cardiac allograft survival.
The Journal of clinical investigation
Bahmani B,Uehara M,Jiang L,Ordikhani F,Banouni N,Ichimura T,Solhjou Z,Furtmüller GJ,Brandacher G,Alvarez D,von Andrian UH,Uchimura K,Xu Q,Vohra I,Yilmam OA,Haik Y,Azzi J,Kasinath V,Bromberg JS,McGrath MM,Abdi R
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Western Blot
Thu Nov 01 00:00:00 EDT 2018
Targeted delivery of immune therapeutics to lymph nodes prolongs cardiac allograft survival.
The Journal of clinical investigation
Bahmani B,Uehara M,Jiang L,Ordikhani F,Banouni N,Ichimura T,Solhjou Z,Furtmüller GJ,Brandacher G,Alvarez D,von Andrian UH,Uchimura K,Xu Q,Vohra I,Yilmam OA,Haik Y,Azzi J,Kasinath V,Bromberg JS,McGrath MM,Abdi R
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Western Blot
Thu Nov 01 00:00:00 EDT 2018
Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection.
The Journal of experimental medicine
Nair S,Huynh JP,Lampropoulou V,Loginicheva E,Esaulova E,Gounder AP,Boon ACM,Schwarzkopf EA,Bradstreet TR,Edelson BT,Artyomov MN,Stallings CL,Diamond MS
14-0032 was used in Flow cytometry/Cell sorting to study the role of Immune responsive gene 1 in the modulation of inflammation during Mycobacterium tuberculosis infection.
Mon Apr 02 00:00:00 EDT 2018
Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Kostrzewski T,Borg AJ,Meng Y,Filipovic I,Male V,Wack A,DiMaggio PA,Brady HJM
14-0032 was used in Flow cytometry/Cell sorting to reveal mechanisms in NK cell development and that E4bp4 is a central hub to process extrinsic stimuli.
Thu Feb 15 00:00:00 EST 2018
Impact of hyperglycemia on autoimmune pancreatitis and regulatory T-cells.
World journal of gastroenterology
Müller-Graff FT,Fitzner B,Jaster R,Vollmar B,Zechner D
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Sat Jul 28 00:00:00 EDT 2018
Neonatal adoptive transfer of lymphocytes rescues social behaviour during adolescence in immune-deficient mice.
The European journal of neuroscience
Clark SM,Vaughn CN,Soroka JA,Li X,Tonelli LH
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Sun Apr 01 00:00:00 EDT 2018
CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema.
Nature communications
García Nores GD,Ly CL,Cuzzone DA,Kataru RP,Hespe GE,Torrisi JS,Huang JJ,Gardenier JC,Savetsky IL,Nitti MD,Yu JZ,Rehal S,Mehrara BJ
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Thu May 17 00:00:00 EDT 2018
Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice.
Journal of neuroinflammation
Unger MS,Schernthaner P,Marschallinger J,Mrowetz H,Aigner L
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Fri Sep 21 00:00:00 EDT 2018
Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice.
mSphere
Quach D,Collins F,Parameswaran N,McCabe L,Britton RA
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Wed Nov 20 00:00:00 EST 2019
Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.
Nature communications
Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Tue Dec 11 00:00:00 EST 2018
Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.
Nature communications
Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Tue Dec 11 00:00:00 EST 2018
The ATP Transporter VNUT Mediates Induction of Dectin-1-Triggered Candida Nociception.
iScience
Maruyama K,Takayama Y,Sugisawa E,Yamanoi Y,Yokawa T,Kondo T,Ishibashi KI,Sahoo BR,Takemura N,Mori Y,Kanemaru H,Kumagai Y,Martino MM,Yoshioka Y,Nishijo H,Tanaka H,Sasaki A,Ohno N,Iwakura Y,Moriyama Y,Nomura M,Akira S,Tominaga M
14-0032 was used in Immunodepletion to indicate that Dectin-1 and VNUT mediated innate sensory mechanisms that detect fungal infection.
Fri Aug 31 00:00:00 EDT 2018
The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection.
Nature immunology
Moffett HF,Cartwright ANR,Kim HJ,Godec J,Pyrdol J,Äijö T,Martinez GJ,Rao A,Lu J,Golub TR,Cantor H,Sharpe AH,Novina CD,Wucherpfennig KW
14-0032 was used in Flow cytometry/Cell sorting to show CD8+ T cell function in chronic viral infection can be modified by microRNA miR-31.
Sat Jul 01 00:00:00 EDT 2017
Characterization of meningeal type 2 innate lymphocytes and their response to CNS injury.
The Journal of experimental medicine
Gadani SP,Smirnov I,Wiltbank AT,Overall CC,Kipnis J
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Immunofluorescence
Wed Feb 01 00:00:00 EST 2017
Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand.
Cancer research
Kang SW,Lee SC,Park SH,Kim J,Kim HH,Lee HW,Seo SK,Kwon BS,Cho HR,Kwon B
14-0032-82 was used in Flow Cytometry to report findings related to reverse signaling by CD137 ligand (CD137L) in antigen-presenting dendritic cells (DC) in tumors that address these paradoxical results.
Wed Nov 01 00:00:00 EDT 2017
The Transcription Factor T-Bet Is Regulated by MicroRNA-155 in Murine Anti-Viral CD8+ T Cells via SHIP-1.
Frontiers in immunology
Hope JL,Stairiker CJ,Spantidea PI,Gracias DT,Carey AJ,Fike AJ,van Meurs M,Brouwers-Haspels I,Rijsbergen LC,Fraietta JA,Mueller YM,Klop RC,Stelekati E,Wherry EJ,Erkeland SJ,Katsikis PD
14-0032 was used in Flow cytometry/Cell sorting to show that the proliferative effect of miR-155 on CD8+T cells is mediated by T-bet. T-bet levels in CTL were controlledin vivoby miR-155viaSH2 (Src homology 2)-containing inositol phosphatase-1 (SHIP-1), a known direct target of miR-155, and SHIP-1 directly downregulated T-bet.
Sat Jan 09 00:00:00 EST 2021
Diet-induced obesity causes visceral, but not subcutaneous, lymph node hyperplasia via increases in specific immune cell populations.
Cell proliferation
Magnuson AM,Regan DP,Fouts JK,Booth AD,Dow SW,Foster MT
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Immunocytochemistry
Sun Oct 01 00:00:00 EDT 2017
Overexpression of fibrinogen-like protein 2 protects against T cell-induced colitis.
World journal of gastroenterology
Bartczak A,Zhang J,Adeyi O,Amir A,Grant D,Gorczynski R,Selzner N,Chruscinski A,Levy GA
Fri Apr 21 00:00:00 EDT 2017
Silybin attenuates LPS-induced lung injury in mice by inhibiting NF-κB signaling and NLRP3 activation.
International journal of molecular medicine
Zhang B,Wang B,Cao S,Wang Y,Wu D
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Mon May 01 00:00:00 EDT 2017
Effect of Early-life Gut Mucosal Compromise on Disease Progression in NOD Mice.
Comparative medicine
Bendtsen KM,Hansen CH,Krych L,Buschard K,Farlov H,Hansen AK
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Sun Oct 01 00:00:00 EDT 2017
Recipient bone marrow assimilates the myeloid/lymphoid reconstitution of distinct fetal hematopoietic stem cells.
Oncotarget
Guo XL,Chu L,Ke F,Mu LL,Li Z,Cai JJ,Li HF,Hong DL
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Tue Dec 12 00:00:00 EST 2017
Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells.
eLife
Lee P,Gund R,Dutta A,Pincha N,Rana I,Ghosh S,Witherden D,Kandyba E,MacLeod A,Kobielak K,Havran WL,Jamora C
14-0032 was used in Functional assays to analyse the signalling components responsible for epithelial stem cell proliferation.
Mon Dec 04 00:00:00 EST 2017
Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells.
eLife
Lee P,Gund R,Dutta A,Pincha N,Rana I,Ghosh S,Witherden D,Kandyba E,MacLeod A,Kobielak K,Havran WL,Jamora C
14-0032 was used in Functional assays to analyse the signalling components responsible for epithelial stem cell proliferation.
Mon Dec 04 00:00:00 EST 2017
Loss of epidermal AP1 transcription factor function reduces filaggrin level, alters chemokine expression and produces an ichthyosis-related phenotype.
Cell death & disease
Young CA,Rorke EA,Adhikary G,Xu W,Eckert RL
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Thu Jun 01 00:00:00 EDT 2017
Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses.
Nature communications
Wang Q,Ning H,Peng H,Wei L,Hou R,Hoft DF,Liu J
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Wed Oct 11 00:00:00 EDT 2017
Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies.
PloS one
Min M,Yan BX,Wang P,Landeck L,Chen JQ,Li W,Cai SQ,Zheng M,Man XY
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Tue Jan 16 00:00:00 EST 2018
The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells.
The Journal of biological chemistry
Chen J,Martindale JL,Cramer C,Gorospe M,Atasoy U,Drew PD,Yu S
14-0032 was used in T-Cell Activation experiments to study how HuR contributes to T helper 17 cell-mediated autoimmune neuroinflammation, and its potential therapeutic target for managing autoimmune conditions of the central nervous system.
Fri Sep 01 00:00:00 EDT 2017
The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models.
Clinical and translational allergy
Vonk MM,Wagenaar L,Pieters RHH,Knippels LMJ,Willemsen LEM,Smit JJ,van Esch BCAM,Garssen J
14-0032 was used in Functional assays to compare oral immunotherapy and subcutaneous immunotherapy models for cows milk and peanut allergy.
Fri Apr 08 00:00:00 EDT 2022
Ex vivo modulation of the Foxo1 phosphorylation state does not lead to dysfunction of T regulatory cells.
PloS one
Penberthy KK,Buckley MW,Arandjelovic S,Ravichandran K
14-0032 was used in Functional assays to study the effect of FoxO1 phosphorylation state on T regulatory cell function.
Fri Aug 25 00:00:00 EDT 2017
Different antiviral effects of IFNα subtypes in a mouse model of HBV infection.
Scientific reports
Song J,Li S,Zhou Y,Liu J,Francois S,Lu M,Yang D,Dittmer U,Sutter K
Thu Mar 23 00:00:00 EDT 2017
Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses.
Nature communications
Cruz-Adalia A,Ramirez-Santiago G,Osuna-Pérez J,Torres-Torresano M,Zorita V,Martínez-Riaño A,Boccasavia V,Borroto A,Martínez Del Hoyo G,González-Granado JM,Alarcón B,Sánchez-Madrid F,Veiga E
14-0032 was used in Immunocytochemistry-immunoflourescence to demonstrate the ability of conventional CD4+ T cells to present bacterial antigens, and elicit anti-tumour immune responses by priming CD8+ T cells.
Fri Nov 17 00:00:00 EST 2017
WASH maintains NKp46+ ILC3 cells by promoting AHR expression.
Nature communications
Xia P,Liu J,Wang S,Ye B,Du Y,Xiong Z,Han ZG,Tong L,Fan Z
14-0032 was used in Flow cytometry/Cell sorting to study how WASH-mediated AHR expression has a critical function in the maintenance of NKp46(+) ILC3s.
Wed Jun 07 00:00:00 EDT 2017
Production and glyco-engineering of immunomodulatory helminth glycoproteins in plants.
Scientific reports
Wilbers RH,Westerhof LB,van Noort K,Obieglo K,Driessen NN,Everts B,Gringhuis SI,Schramm G,Goverse A,Smant G,Bakker J,Smits HH,Yazdanbakhsh M,Schots A,Hokke CH
14-0032 was used in in vivo experiments to determine that plant glycosyltransferases can reconstruct helminth glycoproteins which are potential therapies for immune-related diseases.
Mon Apr 10 00:00:00 EDT 2017
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.
Cell
Clever D,Roychoudhuri R,Constantinides MG,Askenase MH,Sukumar M,Klebanoff CA,Eil RL,Hickman HD,Yu Z,Pan JH,Palmer DC,Phan AT,Goulding J,Gattinoni L,Goldrath AW,Belkaid Y,Restifo NP
14-0032-82 was used in Flow Cytometry to find that T-cell-intrinsic expression of the oxygen-sensing prolyl-hydroxylase proteins is required to maintain local tolerance against innocuous antigens in the lung but powerfully licenses colonization by circulating tumor cells.
Thu Aug 25 00:00:00 EDT 2016
The breast tumor microenvironment alters the phenotype and function of natural killer cells.
Cellular & molecular immunology
Krneta T,Gillgrass A,Chew M,Ashkar AA
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Thu Sep 01 00:00:00 EDT 2016
The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells.
Leukemia
Saulep-Easton D,Vincent FB,Quah PS,Wei A,Ting SB,Croce CM,Tam C,Mackay F
14-0032 was used in Flow cytometry/Cell sorting to uncover a major targetable pathway important for the generation of regulatory B cells that is detrimental to immunity in chronic lymphocytic leukemia.
Fri Jan 01 00:00:00 EST 2016
Intranasal immunization with heat shock protein 60 induces CD4(+) CD25(+) GARP(+) and type 1 regulatory T cells and inhibits early atherosclerosis.
Clinical and experimental immunology
Zhong Y,Tang H,Wang X,Zeng Q,Liu Y,Zhao XI,Yu K,Shi H,Zhu R,Mao X
14-0032 was used in Flow cytometry/Cell sorting to investigate the impact of nasal heat shock protein 60 on atherosclerosis and the mechanisms underlying the anti-atherosclerosis responses.
Tue Mar 01 00:00:00 EST 2016
Differential Responsiveness of Innate-like IL-17- and IFN-γ-Producing γδ T Cells to Homeostatic Cytokines.
Journal of immunology (Baltimore, Md. : 1950)
Corpuz TM,Stolp J,Kim HO,Pinget GV,Gray DH,Cho JH,Sprent J,Webster KE
14-0032 was used in Flow cytometry/Cell sorting to suggest that γδ T cell subsets do not directly compete with each other for cytokines, but instead fall into resource niches with other functionally similar lymphocytes.
Fri Jan 15 00:00:00 EST 2016
Type I IFN Does Not Promote Susceptibility to Foodborne Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950)
Pitts MG,Myers-Morales T,D'Orazio SE
14-0032 was used in Flow cytometry/Cell sorting to investigate whether type I IFN promotes susceptibility to foodborne Listeria monocytogenes.
Fri Apr 01 00:00:00 EDT 2016
Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning.
Journal of immunology (Baltimore, Md. : 1950)
Müller AM,Florek M,Kohrt HE,Küpper NJ,Filatenkov A,Linderman JA,Hadeiba H,Negrin RS,Shizuru JA
14-0032 was used in Flow cytometry/Cell sorting to shed new light on the effects of CD4+ T cells on HSC biology.
Tue Nov 15 00:00:00 EST 2016
Exaggerated IL-15 and Altered Expression of foxp3+ Cell-Derived Cytokines Contribute to Enhanced Colitis in Nlrp3-/- Mice.
Mediators of inflammation
Hirota SA,Ueno A,Tulk SE,Becker HM,Schenck LP,Potentier MS,Li Y,Ghosh S,Muruve DA,MacDonald JA,Beck PL
14-0032 was used in Flow cytometry/Cell sorting to suggest that the NLRP3 inflammasome can regulate intestinal inflammation through noncanonical mechanisms.
Mon Jun 05 00:00:00 EDT 2017
Laminin regulates PDGFRβ(+) cell stemness and muscle development.
Nature communications
Yao Y,Norris EH,Mason CE,Strickland S
14-0032 was used in Immunohistochemistry to show that laminin has a critical role in the control of PDGFRBeta(+) cell stemness and that PDGFRBeta(+) may be a drug target for treatment of muscular dystrophy.
Tue May 03 00:00:00 EDT 2016
CD8(+) T-cell Immune Evasion Enables Oncolytic Virus Immunotherapy.
EBioMedicine
Pourchet A,Fuhrmann SR,Pilones KA,Demaria S,Frey AB,Mulvey M,Mohr I
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2016
NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation.
Nature communications
Yang M,Chen S,Du J,He J,Wang Y,Li Z,Liu G,Peng W,Zeng X,Li D,Xu P,Guo W,Chang Z,Wang S,Tian Z,Dong Z
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Wed Sep 07 00:00:00 EDT 2016
TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection.
Cell reports
Schleicher U,Paduch K,Debus A,Obermeyer S,König T,Kling JC,Ribechini E,Dudziak D,Mougiakakos D,Murray PJ,Ostuni R,Körner H,Bogdan C
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Tue May 03 00:00:00 EDT 2016
Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.
Scientific reports
Ochi T,Feng Y,Kitamoto S,Nagao-Kitamoto H,Kuffa P,Atarashi K,Honda K,Teitelbaum DH,Kamada N
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Wed Jun 15 00:00:00 EDT 2016
miR-150 regulates obesity-associated insulin resistance by controlling B cell functions.
Scientific reports
Ying W,Tseng A,Chang RC,Wang H,Lin YL,Kanameni S,Brehm T,Morin A,Jones B,Splawn T,Criscitiello M,Golding MC,Bazer FW,Safe S,Zhou B
14-0032 was used in Flow cytometry/Cell sorting to demonstrate a role for miR-150 in regulating B cell functions in adipose tissue.
Mon Feb 01 00:00:00 EST 2016
IL-12 protects from psoriasiform skin inflammation.
Nature communications
Kulig P,Musiol S,Freiberger SN,Schreiner B,Gyülveszi G,Russo G,Pantelyushin S,Kishihara K,Alessandrini F,Kündig T,Sallusto F,Hofbauer GF,Haak S,Becher B
14-0032 was used in Flow cytometry/Cell sorting to investigate the individual contribution of IL-12 and IL-23 to the formation of psoriatic lesions and understand the effect of therapeutic co-targeting of these cytokines, showing that IL-12 protects from psoriasiform skin inflammation.
Mon Nov 28 00:00:00 EST 2016
SCIB1, a huIgG1 antibody DNA vaccination, combined with PD-1 blockade induced efficient therapy of poorly immunogenic tumors.
Oncotarget
Xue W,Brentville VA,Symonds P,Cook KW,Yagita H,Metheringham RL,Durrant LG
14-0032 was used in Flow cytometry/Cell sorting to investigate the anti-tumour effect of a huIgG1 antibody DNA vaccine and PD-1 blockade.
Tue Dec 13 00:00:00 EST 2016
Endothelial Cell-Selective Adhesion Molecule Expression in Hematopoietic Stem/Progenitor Cells Is Essential for Erythropoiesis Recovery after Bone Marrow Injury.
PloS one
Sudo T,Yokota T,Okuzaki D,Ueda T,Ichii M,Ishibashi T,Isono T,Habuchi Y,Oritani K,Kanakura Y
14-0032 was used in Flow cytometry/Cell sorting to determine the physiological importance of Endothelial Cell-Selective Adhesion Molecule (ESAM) in erythroid recovery, showing that ESAM is essential for erthryopoiesis recovery following bone marrow injury.
Tue Mar 14 00:00:00 EDT 2017
High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner.
Scientific reports
Polansky JK,Bahri R,Divivier M,Duitman EH,Vock C,Goyeneche-Patino DA,Orinska Z,Bulfone-Paus S
14-0032 was used in Functional assays to analyse the in vivo potential of IL15 as an immune-regulator when available at different concentrations or delivery modes.
Fri Jan 29 00:00:00 EST 2016
Effect of a Ropy Exopolysaccharide-Producing Bifidobacterium animalis subsp. lactis Strain Orally Administered on DSS-Induced Colitis Mice Model.
Frontiers in microbiology
Hidalgo-Cantabrana C,Algieri F,Rodriguez-Nogales A,Vezza T,Martínez-Camblor P,Margolles A,Ruas-Madiedo P,Gálvez J
14-0032 was used in Flow cytometry/Cell sorting to indicate that strains of B. animalis subsp. lactis producing EPS that confer a mucoid-ropy phenotype could represent promising candidates to perform further studies targeting intestinal inflammatory processes.
Mon Jul 04 00:00:00 EDT 2016
Orally administered β-glucan attenuates the Th2 response in a model of airway hypersensitivity.
SpringerPlus
Burg AR,Quigley L,Jones AV,O'Connor GM,Boelte K,McVicar DW,Orr SJ
14-0032 was used in Flow cytometry/Cell sorting to study the immunological effects of WGP containing β-1,3/1,6-glucans in a mouse model of asthma and consider its therapeutic potential.
Fri Jul 08 00:00:00 EDT 2016
The Toll-like receptor 5 agonist entolimod suppresses hepatic metastases in a murine model of ocular melanoma via an NK cell-dependent mechanism.
Oncotarget
Yang H,Brackett CM,Morales-Tirado VM,Li Z,Zhang Q,Wilson MW,Benjamin C,Harris W,Waller EK,Gudkov AV,Burdelya LG,Grossniklaus HE
14-0032 was used in Flow cytometry/Cell sorting to investigate entolimod as an immunotherapeutic agent against hepatic metastasis in a mouse model of ocular melanoma.
Tue Jan 19 00:00:00 EST 2016
Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis.
Nature communications
Guglietta S,Chiavelli A,Zagato E,Krieg C,Gandini S,Ravenda PS,Bazolli B,Lu B,Penna G,Rescigno M
14-0032 was used in Flow cytometry/Cell sorting to provide a mechanistic explanation for the tumour-promoting effects of hypercoagulation.
Mon Mar 21 00:00:00 EDT 2016
Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells.
Oncotarget
Zemanova J,Hylse O,Collakova J,Vesely P,Oltova A,Borsky M,Zaprazna K,Kasparkova M,Janovska P,Verner J,Kohoutek J,Dzimkova M,Bryja V,Jaskova Z,Brychtova Y,Paruch K,Trbusek M
14-0032 was used in Flow cytometry/Cell sorting to compare the effects of adding a Chk1 inhibitor to nucleoside analogs in p53-proficient and p53-defective cells.
Tue Sep 20 00:00:00 EDT 2016
Epidermal Notch1 recruits RORγ(+) group 3 innate lymphoid cells to orchestrate normal skin repair.
Nature communications
Li Z,Hodgkinson T,Gothard EJ,Boroumand S,Lamb R,Cummins I,Narang P,Sawtell A,Coles J,Leonov G,Reboldi A,Buckley CD,Cupedo T,Siebel C,Bayat A,Coles MC,Ambler CA
14-0032 was used in Flow cytometry/Cell sorting to invesitgate whether Notch directs non-cell-autonomous signalling in adult tissues, showing that it recruits RORγ(+) group 3 innate lymphoid cells to orchestrate normal skin repair.
Thu Apr 21 00:00:00 EDT 2016
Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions.
Open biology
Swee LK,Tan ZW,Sanecka A,Yoshida N,Patel H,Grotenbreg G,Frickel EM,Ploegh HL
14-0032 was used in Flow cytometry/Cell sorting to show that potential effector functions and basal proliferation of CD8 T cells are set by self-reactivity thresholds.
Tue Nov 01 00:00:00 EDT 2016
Structural and functional features of central nervous system lymphatic vessels.
Nature
Louveau A,Smirnov I,Keyes TJ,Eccles JD,Rouhani SJ,Peske JD,Derecki NC,Castle D,Mandell JW,Lee KS,Harris TH,Kipnis J
14-0032 was used in Immunohistochemistry-wholemount to investigate the mechanisms governing the entrance and exit of immune cells from the CNS.
Thu Jul 16 00:00:00 EDT 2015
IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis.
The Journal of experimental medicine
Pallangyo CK,Ziegler PK,Greten FR
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Mon Dec 14 00:00:00 EST 2015
Melanocyte antigen triggers autoimmunity in human psoriasis.
The Journal of experimental medicine
Arakawa A,Siewert K,Stöhr J,Besgen P,Kim SM,Rühl G,Nickel J,Vollmer S,Thomas P,Krebs S,Pinkert S,Spannagl M,Held K,Kammerbauer C,Besch R,Dornmair K,Prinz JC
14-0032 was used in Functional assays to determine that a human leukocyte antigen class I allele may predispose to psoriasis via a newly identified pathway.
Mon Dec 14 00:00:00 EST 2015
Melanocyte antigen triggers autoimmunity in human psoriasis.
The Journal of experimental medicine
Arakawa A,Siewert K,Stöhr J,Besgen P,Kim SM,Rühl G,Nickel J,Vollmer S,Thomas P,Krebs S,Pinkert S,Spannagl M,Held K,Kammerbauer C,Besch R,Dornmair K,Prinz JC
14-0032 was used in Functional assays to determine that a human leukocyte antigen class I allele may predispose to psoriasis via a newly identified pathway.
Mon Dec 14 00:00:00 EST 2015
Comparison of predicted and actual consequences of missense mutations.
Proceedings of the National Academy of Sciences of the United States of America
Miosge LA,Field MA,Sontani Y,Cho V,Johnson S,Palkova A,Balakishnan B,Liang R,Zhang Y,Lyon S,Beutler B,Whittle B,Bertram EM,Enders A,Goodnow CC,Andrews TD
14-0032 was used in Flow cytometry/Cell sorting to analyse the efficacy of computational inferences of the functional significance of missense mutations in mice.
Tue Sep 15 00:00:00 EDT 2015
PD-1 or PD-L1 Blockade Restores Antitumor Efficacy Following SSX2 Epitope-Modified DNA Vaccine Immunization.
Cancer immunology research
Rekoske BT,Smith HA,Olson BM,Maricque BB,McNeel DG
14-0032 was used in Flow cytometry/Cell sorting to determine that vaccines aimed at eliciting effector CD8(+) T cells may have improved function when combined with PD-1 pathway inhibitors.
Sat Aug 01 00:00:00 EDT 2015
ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells.
PLoS biology
Gallego-Ortega D,Ledger A,Roden DL,Law AM,Magenau A,Kikhtyak Z,Cho C,Allerdice SL,Lee HJ,Valdes-Mora F,Herrmann D,Salomon R,Young AI,Lee BY,Sergio CM,Kaplan W,Piggin C,Conway JR,Rabinovich B,Millar EK,Oakes SR,Chtanova T,Swarbrick A,Naylor MJ,O'Toole S,Green AR,Timpson P,Gee JM,Ellis IO,Clark SJ,Ormandy CJ
14-0032 was used in Flow cytometry/Cell sorting to implicate ELF5 as a defining factor in the acquisition of the key aspects of the lethal phenotype in luminal A breast cancer.
Tue Dec 01 00:00:00 EST 2015
Cytokine-Mediated Activation of NK Cells during Viral Infection.
Journal of virology
Freeman BE,Raué HP,Hill AB,Slifka MK
14-0032 was used in Flow cytometry/Cell sorting to study how cytokines interact to regulate natural killer cell function during viral infection.
Sat Aug 01 00:00:00 EDT 2015
Pulmonary alveolar macrophages contribute to the premetastatic niche by suppressing antitumor T cell responses in the lungs.
Journal of immunology (Baltimore, Md. : 1950)
Sharma SK,Chintala NK,Vadrevu SK,Patel J,Karbowniczek M,Markiewski MM
14-0032 was used in Flow cytometry/Cell sorting to demonstrate that alveolar macrophages are harnessed by tumours to impose immunosuppression and promote metastasis.
Mon Jun 01 00:00:00 EDT 2015
Monitoring and cell-specific deletion of C5aR1 using a novel floxed GFP-C5aR1 reporter knock-in mouse.
Journal of immunology (Baltimore, Md. : 1950)
Karsten CM,Laumonnier Y,Eurich B,Ender F,Bröker K,Roy S,Czabanska A,Vollbrandt T,Figge J,Köhl J
14-0032 was used in Flow cytometry/Cell sorting to study cell-specific deletion of C5aR1 using a GFP-reporter knock-in mouse model.
Sun Feb 15 00:00:00 EST 2015
Toll-Like Receptor 4 Is an Essential Upstream Regulator of On-Time Parturition and Perinatal Viability in Mice.
Endocrinology
Wahid HH,Dorian CL,Chin PY,Hutchinson MR,Rice KC,Olson DM,Moldenhauer LM,Robertson SA
14-0032 was used in Flow cytometry/Cell sorting to describe TLR4-mediated regulation of the inflammatory response acting to drive uterine activation and control the timing of labour.
Thu Oct 01 00:00:00 EDT 2015
Adjuvants may reduce in vivo transfection levels for DNA vaccination in mice leading to reduced antigen-specific CD8+ T cell responses.
Human vaccines & immunotherapeutics
Rose AH,Hoffmann FW,Hara JH,Urschitz J,Moisyadi S,Hoffmann PR,Bertino P
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Mon May 16 00:00:00 EDT 2016
IL-18 contributes to susceptibility to Leishmania amazonensis infection by macrophage-independent mechanisms.
Cytokine
Sousa LM,Carneiro MB,Dos Santos LM,Natale CC,Resende ME,Mosser DM,Vieira LQ
14-0032 was used in Flow cytometry/Cell sorting to investigate whether or not macrophages are involved in IL-18-mediated susceptibility to L. amazonensis.
Sat Aug 01 00:00:00 EDT 2015
IL-33 Enhances Humoral Immunity Against Chronic HBV Infection Through Activating CD4(+)CXCR5(+) TFH Cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
Zhao PW,Shi X,Li C,Ayana DA,Niu JQ,Feng JY,Wang J,Jiang YF
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Mon Jun 01 00:00:00 EDT 2015
Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling.
Nature communications
Kang YJ,Bang BR,Han KH,Hong L,Shim EJ,Ma J,Lerner RA,Otsuka M
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Fri Sep 18 00:00:00 EDT 2015
Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.
Nature communications
Zanvit P,Konkel JE,Jiao X,Kasagi S,Zhang D,Wu R,Chia C,Ajami NJ,Smith DP,Petrosino JF,Abbatiello B,Nakatsukasa H,Chen Q,Belkaid Y,Chen ZJ,Chen W
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Tue Sep 29 00:00:00 EDT 2015
Amphiregulin activates regulatory T lymphocytes and suppresses CD8+ T cell-mediated anti-tumor response in hepatocellular carcinoma cells.
Oncotarget
Yuan CH,Sun XM,Zhu CL,Liu SP,Wu L,Chen H,Feng MH,Wu K,Wang FB
14-0032 was used in Flow cytometry/Cell sorting to investigate how hepatocellular carcinoma cells alter endogenous anti-tumor immunity and their related signaling pathways.
Tue Oct 13 00:00:00 EDT 2015
DNAM-1 expression marks an alternative program of NK cell maturation.
Cell reports
Martinet L,Ferrari De Andrade L,Guillerey C,Lee JS,Liu J,Souza-Fonseca-Guimaraes F,Hutchinson DS,Kolesnik TB,Nicholson SE,Huntington ND,Smyth MJ
14-0032 was used in Flow cytometry/Cell sorting to reveal the existence of a functional program of NK cell maturation marked by DNAM-1 expression.
Tue Apr 07 00:00:00 EDT 2015
The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis.
Nature communications
Nakasaki M,Hwang Y,Xie Y,Kataria S,Gund R,Hajam EY,Samuel R,George R,Danda D,M J P,Nakamura T,Shen Z,Briggs S,Varghese S,Jamora C
14-0032 was used in Immunohistochemistry on paraffin embedded tissues to investigate the role of Fibulin-5 on matrix stiffness in fibrosis.
Thu Oct 15 00:00:00 EDT 2015
In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice.
Blood
Derderian SC,Togarrati PP,King C,Moradi PW,Reynaud D,Czechowicz A,Weissman IL,MacKenzie TC
14-0032 was used in Flow cytometry/Cell sorting to develop a successful foetal conditioning strategy associated with minimal toxicity.
Thu Aug 07 00:00:00 EDT 2014
Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition.
The Journal of clinical investigation
Bhadra R,Moretto MM,Castillo JC,Petrovas C,Ferrando-Martinez S,Shokal U,Leal M,Koup RA,Eleftherianos I,Khan IA
14-0032 was used in Flow cytometry/Cell sorting to investigate the progressive loss of CD8+ T cell polyfunctionality during aging, using animals challenged with the obligate intracellular pathogen Encephalitozoon cuniculi.
Sun Jun 01 00:00:00 EDT 2014
The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.
The Journal of experimental medicine
Male V,Nisoli I,Kostrzewski T,Allan DS,Carlyle JR,Lord GM,Wack A,Brady HJ
14-0032 was used in Flow cytometry/Cell sorting to propose that E4bp4 is required for commitment to the NK lineage and can promote NK development by directly regulating the expression of the downstream transcription factors Eomes and Id2.
Mon Apr 07 00:00:00 EDT 2014
Myeloid-derived suppressor cell function is diminished in aspirin-triggered allergic airway hyperresponsiveness in mice.
The Journal of allergy and clinical immunology
Shi M,Shi G,Tang J,Kong D,Bao Y,Xiao B,Zuo C,Wang T,Wang Q,Shen Y,Wang H,Funk CD,Zhou J,Yu Y
14-0032 was used in Flow cytometry/Cell sorting to characterise myeloid-derived suppressor cell accumulation and pathogenic functions in allergic airway inflammation mediated by COX-1 deficiency or aspirin treatment in mice.
Sat Nov 01 00:00:00 EDT 2014
Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis.
EMBO molecular medicine
Basler M,Mundt S,Muchamuel T,Moll C,Jiang J,Groettrup M,Kirk CJ
14-0032 was used in Functional assays to investigate the therapeutic efficacy of an immunoproteasome inhibitor, ONX 0914, in two different mouse models of multiple sclerosis.
Sat Feb 01 00:00:00 EST 2014
Complement c5a receptor facilitates cancer metastasis by altering T-cell responses in the metastatic niche.
Cancer research
Vadrevu SK,Chintala NK,Sharma SK,Sharma P,Cleveland C,Riediger L,Manne S,Fairlie DP,Gorczyca W,Almanza O,Karbowniczek M,Markiewski MM
14-0032 was used in Functional assays to study the impact of the complement system on cancer metastasis.
Tue Jul 01 00:00:00 EDT 2014
Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages.
Proceedings of the National Academy of Sciences of the United States of America
Rei M,Gonçalves-Sousa N,Lança T,Thompson RG,Mensurado S,Balkwill FR,Kulbe H,Pennington DJ,Silva-Santos B
14-0032 was used in Flow cytometry/Cell sorting to characterise the role of tumour-associated γδ T cells on disease development using a model peritoneal/ovarian cancer cell line.
Tue Aug 26 00:00:00 EDT 2014
Leukocyte invasion of the brain after experimental intracerebral hemorrhage in mice.
Stroke
Mracsko E,Javidi E,Na SY,Kahn A,Liesz A,Veltkamp R
14-0032 was used in Flow cytometry/Cell sorting to characterize the time course of brain immigration of different leukocyte subsets after striatal injection in mice.
Tue Jul 01 00:00:00 EDT 2014
Chronic hydroxychloroquine improves endothelial dysfunction and protects kidney in a mouse model of systemic lupus erythematosus.
Hypertension (Dallas, Tex. : 1979)
Gómez-Guzmán M,Jiménez R,Romero M,Sánchez M,Zarzuelo MJ,Gómez-Morales M,O'Valle F,López-Farré AJ,Algieri F,Gálvez J,Pérez-Vizcaino F,Sabio JM,Duarte J
14-0032 was used in Blocking experiments to investigate the effects of hydroxychloroquine on hypertension, endothelial dysfunction, and renal injury in a mouse model of systemic lupus erythematosus.
Fri Aug 01 00:00:00 EDT 2014
Inhibition of the TRAIL death receptor by CMV reveals its importance in NK cell-mediated antiviral defense.
PLoS pathogens
Verma S,Loewendorf A,Wang Q,McDonald B,Redwood A,Benedict CA
14-0032 was used in Flow cytometry/Cell sorting to highlight the critical importance for CMV to have evolved a strategy to inhibit TRAIL-DR signaling to thwart NK-mediated defenses.
Fri Aug 01 00:00:00 EDT 2014
Paradoxical resistance to high-fat diet-induced obesity and altered macrophage polarization in mineralocorticoid receptor-overexpressing mice.
American journal of physiology. Endocrinology and metabolism
Kuhn E,Bourgeois C,Keo V,Viengchareun S,Muscat A,Meduri G,Le Menuet D,Fève B,Lombès M
14-0032 was used in Flow cytometry/Cell sorting to investigate the in vivo metabolic impact of the mineralocorticoid receptor (MR), showing that overexpression of MR leads to resistance to high-fat diet-induced obesity and altered macrophage polarisation.
Wed Jan 01 00:00:00 EST 2014
Histone deacetylation critically determines T cell subset radiosensitivity.
Journal of immunology (Baltimore, Md. : 1950)
Pugh JL,Sukhina AS,Seed TM,Manley NR,Sempowski GD,van den Brink MR,Smithey MJ,Nikolich-Žugich J
14-0032 was used in Flow cytometry/Cell sorting to investigate the radiosensitivity of native, effector and central memory T cell subsets.
Fri Aug 01 00:00:00 EDT 2014
Deficiency of lymph node-resident dendritic cells (DCs) and dysregulation of DC chemoattractants in a malnourished mouse model of Leishmania donovani infection.
Infection and immunity
Ibrahim MK,Barnes JL,Osorio EY,Anstead GM,Jimenez F,Osterholzer JJ,Travi BL,Ahuja SS,White AC,Melby PC
14-0032 was used in Flow cytometry/Cell sorting to study populations of resident dendritic cells and migratory dermal dendritic cells in the skin-draining lymph nodes of L. donovani-infected malnourished mice.
Fri Aug 01 00:00:00 EDT 2014
KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3⁺ regulatory T cells in MRL/lpr mice.
Autoimmunity
Koga T,Mizui M,Yoshida N,Otomo K,Lieberman LA,Crispín JC,Tsokos GC
14-0032 was used in Flow cytometry/Cell sorting to investigate the mechanism of CaMK4 on Treg cells in systemic lupus erythematosus, showing that inhibition promotes generation and function of Foxp3+ Tregs.
Sat Nov 01 00:00:00 EDT 2014
A chitin-like component on sclerotic cells of Fonsecaea pedrosoi inhibits Dectin-1-mediated murine Th17 development by masking β-glucans.
PloS one
Dong B,Li D,Li R,Chen SC,Liu W,Liu W,Chen L,Chen Y,Zhang X,Tong Z,Xia Y,Xia P,Wang Y,Duan Y
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Mon Sep 28 00:00:00 EDT 2015
Leukocyte population dynamics and detection of IL-9 as a major cytokine at the mouse fetal-maternal interface.
PloS one
Habbeddine M,Verbeke P,Karaz S,Bobé P,Kanellopoulos-Langevin C
Published figure using CD3 monoclonal antibody (Product # 14-0032-82) in Flow Cytometry
Wed Jun 10 00:00:00 EDT 2015
NAD+ protects against EAE by regulating CD4+ T-cell differentiation.
Nature communications
Tullius SG,Biefer HR,Li S,Trachtenberg AJ,Edtinger K,Quante M,Krenzien F,Uehara H,Yang X,Kissick HT,Kuo WP,Ghiran I,de la Fuente MA,Arredouani MS,Camacho V,Tigges JC,Toxavidis V,El Fatimy R,Smith BD,Vasudevan A,ElKhal A
14-0032 was used in Functional assays to investigate the role of NAD+ in experimental autoimmune encephalomyelitis.
Tue Oct 07 00:00:00 EDT 2014
A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling.
Circulation research
Chen YC,Bui AV,Diesch J,Manasseh R,Hausding C,Rivera J,Haviv I,Agrotis A,Htun NM,Jowett J,Hagemeyer CE,Hannan RD,Bobik A,Peter K
14-0032 was used in Immunohistochemistry to develop and test therapeutic strategies aimed at preventing plaque rupture.
Fri Jul 19 00:00:00 EDT 2013
Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation.
The Journal of clinical investigation
Gandhirajan RK,Meng S,Chandramoorthy HC,Mallilankaraman K,Mancarella S,Gao H,Razmpour R,Yang XF,Houser SR,Chen J,Koch WJ,Wang H,Soboloff J,Gill DL,Madesh M
14-0032 was used in Flow cytometry/Cell sorting to elucidate the molecular mechanisms behind the development of LPS-induced acute lung injury.
Fri Feb 01 00:00:00 EST 2013
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.
Nature chemical biology
Hartwell KA,Miller PG,Mukherjee S,Kahn AR,Stewart AL,Logan DJ,Negri JM,Duvet M,Järås M,Puram R,Dancik V,Al-Shahrour F,Kindler T,Tothova Z,Chattopadhyay S,Hasaka T,Narayan R,Dai M,Huang C,Shterental S,Chu LP,Haydu JE,Shieh JH,Steensma DP,Munoz B,Bittker JA,Shamji AF,Clemons PA,Tolliday NJ,Carpenter AE,Gilliland DG,Stern AM,Moore MAS,Scadden DT,Schreiber SL,Ebert BL,Golub TR
14-0032 was used in Flow cytometry/Cell sorting to illustrate the power of merging physiologically relevant models with high-throughput screening to develop more effective therapies for acute leukemia.
Sun Dec 01 00:00:00 EST 2013
IL-4Rα on CD4+ T cells plays a pathogenic role in respiratory syncytial virus reinfection in mice infected initially as neonates.
Journal of leukocyte biology
You D,Marr N,Saravia J,Shrestha B,Lee GI,Turvey SE,Brombacher F,Herbert DR,Cormier SA
14-0032 was used in Flow cytometry/Cell sorting to demonstrate that IL-4Rα is up-regulated in vitro on T cells from cord blood following respiratory syncytial virus stimulation.
Sat Jun 01 00:00:00 EDT 2013
Alcam regulates long-term hematopoietic stem cell engraftment and self-renewal.
Stem cells (Dayton, Ohio)
Jeannet R,Cai Q,Liu H,Vu H,Kuo YH
14-0032 was used in Flow cytometry/Cell sorting to investigate the role of activated leukocyte cell adhesion molecule in hematopoietic stem cell differentiation and self-renewal using an Alcam-null mouse model.
Fri Mar 01 00:00:00 EST 2013
Interferon gamma causes olfactory dysfunction without concomitant neuroepithelial damage.
International forum of allergy & rhinology
Pozharskaya T,Lane AP
14-0032 was used in Immunohistochemistry to investigate the direct effect of IFN-γ on olfactory neuron function that may underlie olfactory loss in CRSsNP or viral infections.
Fri Nov 01 00:00:00 EDT 2013
Interruption of dendritic cell-mediated TIM-4 signaling induces regulatory T cells and promotes skin allograft survival.
Journal of immunology (Baltimore, Md. : 1950)
Yeung MY,McGrath MM,Nakayama M,Shimizu T,Boenisch O,Magee CN,Abdoli R,Akiba H,Ueno T,Turka LA,Najafian N
14-0032 was used in in vitro experiments to show that blockade of dendritic cell-expressed TIM-4 leads to increased induction of induced regulatory T cells from naive T cells.
Tue Oct 15 00:00:00 EDT 2013
Osteoclast-induced Foxp3+ CD8 T-cells limit bone loss in mice.
Bone
Buchwald ZS,Kiesel JR,Yang C,DiPaolo R,Novack DV,Aurora R
14-0032 was used in Flow cytometry/Cell sorting to provide in vivo evidence that osteoclast-induced Treg cells have anti-resorptive activity and repress the immune system.
Sun Sep 01 00:00:00 EDT 2013
Toll-like receptor 7 mediates early innate immune responses to malaria.
Infection and immunity
Baccarella A,Fontana MF,Chen EC,Kim CC
14-0032 was used in Flow cytometry/Cell sorting to investigate other MYD88-dependent receptors contributing to antimalarial responses, showing that toll-like receptor 7 mediates early innate immune responses to malaria.
Sun Dec 01 00:00:00 EST 2013
Neuronal and nonneuronal cholinergic structures in the mouse gastrointestinal tract and spleen.
The Journal of comparative neurology
Gautron L,Rutkowski JM,Burton MD,Wei W,Wan Y,Elmquist JK
14-0032 was used in Immunohistochemistry to describe a variety of cholinergic neuronal and non-neuronal cells that modulate gastrointestinal and splenic immunity.
Fri Nov 01 00:00:00 EDT 2013
Tumour-derived exosomes as antigen delivery carriers in dendritic cell-based immunotherapy for malignant mesothelioma.
Journal of extracellular vesicles
Mahaweni NM,Kaijen-Lambers ME,Dekkers J,Aerts JG,Hegmans JP
14-0032 was used in Immunohistochemistry on frozen tissues to investigate the use of tumour-derived exosomes for dendritic cell-based immunotherapy for malignant mesothelioma.
Wed Nov 13 00:00:00 EST 2013
Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis.
The Journal of biological chemistry
Steelman AJ,Smith R,Welsh CJ,Li J
14-0032 was used in Immunofluorescence-cell culture cells to investigate the role of galectin-9 in the pathogenesis of multiple sclerosis.
Fri Aug 16 00:00:00 EDT 2013
Thymic stromal lymphopoietin attenuates the development of atherosclerosis in ApoE-/- mice.
Journal of the American Heart Association
Yu K,Zhu P,Dong Q,Zhong Y,Zhu Z,Lin Y,Huang Y,Meng K,Ji Q,Yi G,Zhang W,Wu B,Mao Y,Cheng P,Zhao X,Mao X,Zeng Q
14-0032 was used in Functional assays to examine the phenotype of TSLP-conditioned bone marrow dendritic cells of apolipoprotein E-deficient mice and their capacity to induce the differentiation of Tregs.
Wed Aug 28 00:00:00 EDT 2013
Differential and site specific impact of B cells in the protective immune response to Mycobacterium tuberculosis in the mouse.
PloS one
Torrado E,Fountain JJ,Robinson RT,Martino CA,Pearl JE,Rangel-Moreno J,Tighe M,Dunn R,Cooper AM
14-0032 was used in an ELISpot assay to elucidate the role of B cells for the control of mycobacterial infections.
Thu Nov 14 00:00:00 EST 2013
Differential and site specific impact of B cells in the protective immune response to Mycobacterium tuberculosis in the mouse.
PloS one
Torrado E,Fountain JJ,Robinson RT,Martino CA,Pearl JE,Rangel-Moreno J,Tighe M,Dunn R,Cooper AM
14-0032 was used in an ELISpot assay to elucidate the role of B cells for the control of mycobacterial infections.
Thu Nov 14 00:00:00 EST 2013
An in vivo immunotherapy screen of costimulatory molecules identifies Fc-OX40L as a potent reagent for the treatment of established murine gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research
Murphy KA,Lechner MG,Popescu FE,Bedi J,Decker SA,Hu P,Erickson JR,O'Sullivan MG,Swier L,Salazar AM,Olin MR,Epstein AL,Ohlfest JR
14-0032 was used in Flow cytometry/Cell sorting to investigate the combination of a tumor lysate vaccine with a panel of costimulatory molecules for treatment of gliomas.
Sat Sep 01 00:00:00 EDT 2012
Differential expression of microRNAs during allograft rejection.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Wei L,Wang M,Qu X,Mah A,Xiong X,Harris AG,Phillips LK,Martinez OM,Krams SM
14-0032 was used in Immunohistochemistry to investigate microRNA expression in a model of heterotopic heart transplantation during allograft rejection.
Tue May 01 00:00:00 EDT 2012
Incomplete TCR-β allelic exclusion accelerates spontaneous autoimmune arthritis in K/BxN TCR transgenic mice.
European journal of immunology
Auger JL,Haasken S,Steinert EM,Binstadt BA
14-0032 was used in Flow cytometry/Cell sorting to highlight dual TCR-β expression as a mechanism that can enhance the maturation of autoreactive pathogenic T cells and lead to more rapid development of autoimmune disease.
Sat Sep 01 00:00:00 EDT 2012
Kupffer cells express a unique combination of phenotypic and functional characteristics compared with splenic and peritoneal macrophages.
Journal of leukocyte biology
Movita D,Kreefft K,Biesta P,van Oudenaren A,Leenen PJ,Janssen HL,Boonstra A
14-0032 was used in Immunohistochemistry to observe that freshly isolated Kupffer cells are endocytic and show a relatively high basal ROS content.
Mon Oct 01 00:00:00 EDT 2012
Calcium/calmodulin-dependent protein kinase IV suppresses IL-2 production and regulatory T cell activity in lupus.
Journal of immunology (Baltimore, Md. : 1950)
Koga T,Ichinose K,Mizui M,Crispín JC,Tsokos GC
14-0032 was used in Flow cytometry/Cell sorting to demonstrate that calcium/calmodulin-dependent protein kinase IV plays a central role in development of autoimmunity in MRL/lpr mice.
Mon Oct 01 00:00:00 EDT 2012
The endothelial antigen ESAM monitors hematopoietic stem cell status between quiescence and self-renewal.
Journal of immunology (Baltimore, Md. : 1950)
Sudo T,Yokota T,Oritani K,Satoh Y,Sugiyama T,Ishida T,Shibayama H,Ezoe S,Fujita N,Tanaka H,Maeda T,Nagasawa T,Kanakura Y
14-0032 was used in Flow cytometry/Cell sorting to demonstrate that the intensity of ESAM expression is useful to trace activated HSCs.
Sun Jul 01 00:00:00 EDT 2012
Intratumoral hu14.18-IL-2 (IC) induces local and systemic antitumor effects that involve both activated T and NK cells as well as enhanced IC retention.
Journal of immunology (Baltimore, Md. : 1950)
Yang RK,Kalogriopoulos NA,Rakhmilevich AL,Ranheim EA,Seo S,Kim K,Alderson KL,Gan J,Reisfeld RA,Gillies SD,Hank JA,Sondel PM
14-0032 was used in Immunohistochemistry to study how IT-IC resulted in increased numbers of activated T and NK cells within tumours, better IC retention in the tumour, enhanced inhibition of tumour growth, and improved survival compared with i.v.-IC.
Sat Sep 01 00:00:00 EDT 2012
Mannose-capped lipoarabinomannan from Mycobacterium tuberculosis preferentially inhibits sphingosine-1-phosphate-induced migration of Th1 cells.
Journal of immunology (Baltimore, Md. : 1950)
Richmond JM,Lee J,Green DS,Kornfeld H,Cruikshank WW
14-0032 was used in Flow cytometry/Cell sorting to examine the ability of ManLAM to desensitize T cells to other chemoattractants during mycobacterial infection.
Sat Dec 15 00:00:00 EST 2012
TLR9 and MyD88 are crucial for the development of protective immunity to malaria.
Journal of immunology (Baltimore, Md. : 1950)
Gowda NM,Wu X,Gowda DC
14-0032 was used in Flow cytometry/Cell sorting to investigate TLR9 and MyD88 regulation of pro/anti-inflammatory cytokines in mice infected with Plasmodium yoelii.
Tue May 15 00:00:00 EDT 2012
Loss of T regulatory cell suppression following signaling through glucocorticoid-induced tumor necrosis receptor (GITR) is dependent on c-Jun N-terminal kinase activation.
The Journal of biological chemistry
Joetham A,Ohnishi H,Okamoto M,Takeda K,Schedel M,Domenico J,Dakhama A,Gelfand EW
14-0032 was used in Flow cytometry/Cell sorting to demonstrate that regulation of JNK phosphorylation plays a central role in Treg cell function.
Fri May 18 00:00:00 EDT 2012
TGF-β sensitivity restrains CD8+ T cell homeostatic proliferation by enforcing sensitivity to IL-7 and IL-15.
PloS one
Johnson LD,Jameson SC
14-0032 was used in Flow cytometry/Cell sorting to analyse the response of transgenic naive CD8+ T cells with impaired TGF-β sensitivity to lymphopenia.
Thu Jan 10 00:00:00 EST 2013
Mycophenolate mofetil decreases atherosclerotic lesion size by depression of aortic T-lymphocyte and interleukin-17-mediated macrophage accumulation.
Journal of the American College of Cardiology
von Vietinghoff S,Koltsova EK,Mestas J,Diehl CJ,Witztum JL,Ley K
14-0032 was used in Immunohistochemistry to investigate whether immunosuppression with mycophenolate mofetil inhibits atherosclerosis development in Apoe(-/-) mice.
Tue May 24 00:00:00 EDT 2011
A novel role for IL-22R1 as a driver of inflammation.
Blood
Savan R,McFarland AP,Reynolds DA,Feigenbaum L,Ramakrishnan K,Karwan M,Shirota H,Klinman DM,Dunleavy K,Pittaluga S,Anderson SK,Donnelly RP,Wilson WH,Young HA
14-0032 was used in Flow cytometry/Cell sorting to document a previously unknown role of IL-22R1 in inflammation and identifies the involvement of IL-22R1/IL-22 in ALK(+)ALCL.
Thu Jan 13 00:00:00 EST 2011
S1P is associated with protection in human and experimental cerebral malaria.
Molecular medicine (Cambridge, Mass.)
Finney CA,Hawkes CA,Kain DC,Dhabangi A,Musoke C,Cserti-Gazdewich C,Oravecz T,Liles WC,Kain KC
14-0032 was used in Flow cytometry/Cell sorting to study dysregulation of the S1P pathway in the pathogenesis of human and murine cerebral malaria.
Tue Dec 27 00:00:00 EST 2011
Increased incidence of endometrioid tumors caused by aberrations in E-cadherin promoter of mismatch repair-deficient mice.
Carcinogenesis
Kovtun IV,Harris KJ,Jatoi A,Jevremovic D
Fri Jul 01 00:00:00 EDT 2011
Lidocaine suppresses mouse Peyer's Patch T cell functions and induces bacterial translocation.
Surgery
Kawasaki T,Kawasaki C,Sata T,Chaudry IH
14-0032 was used in Flow cytometry/Cell sorting to examine if lidocaine has any effects on mouse Peyer's patch T cell functions.
Sat Jan 01 00:00:00 EST 2011
Adjuvant properties of a biocompatible thermo-responsive polymer of N-isopropylacrylamide in autoimmunity and arthritis.
Journal of the Royal Society, Interface
Shakya AK,Kumar A,Nandakumar KS
14-0032 was used in Functional assays to evaluate the potential of a temperature-responsive polymer for use as an adjuvant in several immunological applications.
Wed Dec 07 00:00:00 EST 2011
Localized delivery of interferon-β by Lactobacillus exacerbates experimental colitis.
PloS one
McFarland AP,Savan R,Wagage S,Addison A,Ramakrishnan K,Karwan M,Duong T,Young HA
14-0032 was used in Flow cytometry/Cell sorting to identify a correlation between the loss/down-regulation of IFNAR1 on DCs and exacerbation of colitis.
Fri Feb 18 00:00:00 EST 2011
Identification of Baicalin as an immunoregulatory compound by controlling T(H)17 cell differentiation.
PloS one
Yang J,Yang X,Chu Y,Li M
14-0032 was used in Flow cytometry/Cell sorting to show that Baicalin inhibited T(H)17 cell differentiation and thus has the potential to be used as a therapeutic for T(H)17 cell-mediated inflammatory diseases.
Wed Feb 16 00:00:00 EST 2011
FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia.
PloS one
Liesz A,Sun L,Zhou W,Schwarting S,Mracsko E,Zorn M,Bauer H,Sommer C,Veltkamp R
14-0032 was used in Flow cytometry/Cell sorting to detect a reduction of lymphocyte brain invasion by FTY720.
Fri Oct 14 00:00:00 EDT 2011
Notch dimerization is required for leukemogenesis and T-cell development.
Genes & development
Liu H,Chi AW,Arnett KL,Chiang MY,Xu L,Shestova O,Wang H,Li YM,Bhandoola A,Aster JC,Blacklow SC,Pear WS
14-0032 was used in Flow cytometry/Cell sorting to show that dimeric Notch transcriptional complexes are required for T-cell maturation and leukemic transformation but are dispensable for T-cell fate specification from a multipotential precursor.
Mon Nov 01 00:00:00 EDT 2010
T cells from burn-injured mice demonstrate a loss of sensitivity to glucocorticoids.
American journal of physiology. Endocrinology and metabolism
D'Elia M,Patenaude J,Dupras C,Bernier J
14-0032 was used in Functional assays to investigate T cell sensitivity to glucocorticoids following thermal injury and to identify mechanisms that could modulate their sensitivity.
Sun Aug 01 00:00:00 EDT 2010
ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation.
Journal of immunology (Baltimore, Md. : 1950)
Armstrong AJ,Gebre AK,Parks JS,Hedrick CC
14-0032 was used in Flow cytometry/Cell sorting to demonstrate that ATP-binding cassette transporter G1 regulates cholesterol homeostasis in thymocytes and peripheral CD4 T cells.
Fri Jan 01 00:00:00 EST 2010
Prevention of experimental colitis by a selective inhibitor of the immunoproteasome.
Journal of immunology (Baltimore, Md. : 1950)
Basler M,Dajee M,Moll C,Groettrup M,Kirk CJ
14-0032 was used in Functional assays to investigate the effect of immunoproteasomes on the development of dextran sulfate sodium-induced colitis.
Thu Jul 01 00:00:00 EDT 2010
Auf1/Hnrnpd-deficient mice develop pruritic inflammatory skin disease.
The Journal of investigative dermatology
Sadri N,Schneider RJ
14-0032 was used in Flow cytometry/Cell sorting to highlight HNRNPD and mRNA stability as important for the processes of leukocyte recruitment and inflammatory activation within the skin.
Sun Mar 01 00:00:00 EST 2009
Gene expression profiling of leukemia stem cells.
Methods in molecular biology (Clifton, N.J.)
Krivtsov AV,Wang Y,Feng Z,Armstrong SA
14-0032 was used in Flow cytometry/Cell sorting to illustrate methods to isolate a leukemia stem cell population, amplify RNA, and perform microarray analyses.
Tue May 19 00:00:00 EDT 2009
Interferon-alpha initiates type 1 diabetes in nonobese diabetic mice.
Proceedings of the National Academy of Sciences of the United States of America
Li Q,Xu B,Michie SA,Rubins KH,Schreriber RD,McDevitt HO
14-0032 was used in Immunohistochemistry to identify changes in CD4(+) T cell gene expression during the development of diabetes in nonobese diabetic mice.
Tue Aug 26 00:00:00 EDT 2008
Comparison of MMP-2 and MMP-9 secretion from T helper 0, 1 and 2 lymphocytes alone and in coculture with macrophages.
Immunology
Oviedo-Orta E,Bermudez-Fajardo A,Karanam S,Benbow U,Newby AC
14-0032 was used in Functional assays to investigate whether proinflammatory mouse Th1 lymphocytes are more active in Metalloproteinase secretion than naive Th0 or anti-inflammatory Th2 phenotypes, in the absence of specific antigenic stimulation.
Thu May 01 00:00:00 EDT 2008
Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice.
PloS one
Banerjee R,Mosley RL,Reynolds AD,Dhar A,Jackson-Lewis V,Gordon PH,Przedborski S,Gendelman HE
14-0032 was used in Immunohistochemistry on frozen tissues to investigate the role of T cell immunity in human G93A SOD1 Tg mice and in ALS patients.
Wed Jul 23 00:00:00 EDT 2008
Role of naturally occurring CD4+ CD25+ regulatory T cells in experimental atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology
Mor A,Planer D,Luboshits G,Afek A,Metzger S,Chajek-Shaul T,Keren G,George J
14-0032 was used in in vivo experiments to demonstrate that CD4+CD25+ Tregs may be protective in atherosclerosis progression and could be considered a therapeutic tool.
Sun Apr 01 00:00:00 EDT 2007
Measles virus infection of SLAM (CD150) knockin mice reproduces tropism and immunosuppression in human infection.
Journal of virology
Ohno S,Ono N,Seki F,Takeda M,Kura S,Tsuzuki T,Yanagi Y
14-0032 was used in Flow cytometry/Cell sorting to investigate the effects on measles infection after replacement of the V domain of mouse SLAM with human SLAM.
Thu Feb 01 00:00:00 EST 2007
Measles virus infection of SLAM (CD150) knockin mice reproduces tropism and immunosuppression in human infection.
Journal of virology
Ohno S,Ono N,Seki F,Takeda M,Kura S,Tsuzuki T,Yanagi Y
14-0032 was used in Flow cytometry/Cell sorting to investigate the effects on measles infection after replacement of the V domain of mouse SLAM with human SLAM.
Thu Feb 01 00:00:00 EST 2007
17beta-estradiol downregulates interferon regulatory factor-1 in murine splenocytes.
Journal of molecular endocrinology
Lengi AJ,Phillips RA,Karpuzoglu E,Ahmed SA
14-0032 was used in Flow cytometry/Cell sorting to show that estrogen regulates IFN-gamma-inducible IRF-1 in lymphoid cells, a finding that may have implications to IFN-gamma-regulated immune and vascular diseases.
Fri Dec 01 00:00:00 EST 2006
C5a receptor deficiency attenuates T cell function and renal disease in MRLlpr mice.
Journal of the American Society of Nephrology : JASN
Wenderfer SE,Ke B,Hollmann TJ,Wetsel RA,Lan HY,Braun MC
14-0032 was used in Flow cytometry/Cell sorting to indicate the role of the C5a receptor in modulating complement-dependent renal injury and Th-1 responses in MRLlpr mice.
Thu Dec 01 00:00:00 EST 2005
