Product References
Impact of broad-spectrum antibiotics on the gut-microbiota-spleen-brain axis.
Brain, behavior, & immunity - health
Wan X,Eguchi A,Sakamoto A,Fujita Y,Yang Y,Qu Y,Hatano M,Mori C,Hashimoto K
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2023
Spleen-targeted neoantigen DNA vaccine for personalized immunotherapy of hepatocellular carcinoma.
EMBO molecular medicine
Wu M,Luo Z,Cai Z,Mao Q,Li Z,Li H,Zhang C,Zhang Y,Zhong A,Wu L,Liu X
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Wed Oct 11 00:00:00 EDT 2023
CXCR1 drives the pathogenesis of EAE and ARDS via boosting dendritic cells-dependent inflammation.
Cell death & disease
Zhuang W,Zhou J,Zhong L,Lv J,Zhong X,Liu G,Xie L,Wang C,Saimaier K,Han S,Shi C,Hua Q,Zhang R,Xie X,Du C
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Thu Sep 14 00:00:00 EDT 2023
Platelet factors attenuate inflammation and rescue cognition in ageing.
Nature
Schroer AB,Ventura PB,Sucharov J,Misra R,Chui MKK,Bieri G,Horowitz AM,Smith LK,Encabo K,Tenggara I,Couthouis J,Gross JD,Chan JM,Luke A,Villeda SA
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2023
Klebsiella pneumoniae Induces Inflammatory Bowel Disease Through Caspase-11-Mediated IL18 in the Gut Epithelial Cells.
Cellular and molecular gastroenterology and hepatology
Zhang Q,Su X,Zhang C,Chen W,Wang Y,Yang X,Liu D,Zhang Y,Yang R
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Thu Feb 23 00:00:00 EST 2023
Icariin restrains NLRP3 inflammasome-mediated Th2 immune responses and ameliorates atopic dermatitis through modulating a novel lncRNA MALAT1/miR-124-3p axis.
Pharmaceutical biology
Zhao W,Yu HH,Meng WW,Liu AM,Zhang BX,Wang Y,Li J,Wang L,Fang YF
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Fri Dec 01 00:00:00 EST 2023
Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration.
Cell metabolism
Becker M,Joseph SS,Garcia-Carrizo F,Tom RZ,Opaleva D,Serr I,Tschöp MH,Schulz TJ,Hofmann SM,Daniel C
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Tue Oct 03 00:00:00 EDT 2023
Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function.
British journal of pharmacology
Liao W,Foo HYC,Tran TNQ,Chai CLL,Wong WSF
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2023
Palmitoyl transferases act as novel drug targets for pancreatic cancer.
Journal of translational medicine
Lin Z,Lv Z,Liu X,Huang K
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Mon Apr 10 00:00:00 EDT 2023
SARS-CoV-2 spike protein promotes inflammatory cytokine activation and aggravates rheumatoid arthritis.
Cell communication and signaling : CCS
Lee AR,Woo JS,Lee SY,Lee YS,Jung J,Lee CR,Park SH,Cho ML
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Thu Mar 02 00:00:00 EST 2023
TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions.
Frontiers in immunology
O'Neill TJ,Gewies A,Seeholzer T,Krappmann D
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Mon Feb 13 00:00:00 EST 2023
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2023
Complete Freund's Adjuvant Induces a Fibroblast-like Synoviocytes (FLS) Metabolic and Migratory Phenotype in Resident Fibroblasts of the Inoculated Footpad at the Earliest Stage of Adjuvant-Induced Arthritis.
Cells
González-Chávez SA,Chaparro-Barrera E,Alvarado-Jáquez MF,Cuevas-Martínez R,Ochoa-Albíztegui RE,Pacheco-Tena C
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Immunohistochemistry
Wed Mar 08 00:00:00 EST 2023
Aryl hydrocarbon receptor activation ameliorates experimental colitis by modulating the tolerogenic dendritic and regulatory T cell formation.
Cell & bioscience
Cui X,Ye Z,Wang D,Yang Y,Jiao C,Ma J,Tang N,Zhang H
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Sat Apr 23 00:00:00 EDT 2022
IL-33 induces thymic involution-associated naive T cell aging and impairs host control of severe infection.
Nature communications
Xu L,Wei C,Chen Y,Wu Y,Shou X,Chen W,Lu D,Sun H,Li W,Yu B,Wang X,Zhang X,Yu Y,Lei Z,Tang R,Zhu J,Li Y,Lu L,Zhou H,Zhou S,Su C,Chen X
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Sat Nov 12 00:00:00 EST 2022
Fringe GlcNAc-transferases differentially extend O-fucose on endogenous NOTCH1 in mouse activated T cells.
The Journal of biological chemistry
Matsumoto K,Kumar V,Varshney S,Nairn AV,Ito A,Pennarubia F,Moremen KW,Stanley P,Haltiwanger RS
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Fri Jul 01 00:00:00 EDT 2022
Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling.
Nature communications
Xie F,Zhou X,Su P,Li H,Tu Y,Du J,Pan C,Wei X,Zheng M,Jin K,Miao L,Wang C,Meng X,van Dam H,Ten Dijke P,Zhang L,Zhou F
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2022
Black raspberry extract inhibits regulatory T-cell activity in a murine model of head and neck squamous cell carcinoma chemoprevention.
Frontiers in immunology
Ryan NM,Lamenza FF,Upadhaya P,Pracha H,Springer A,Swingler M,Siddiqui A,Oghumu S
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Immunohistochemistry
Mon Aug 29 00:00:00 EDT 2022
Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.
The Journal of experimental medicine
Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Mon Apr 05 00:00:00 EDT 2021
Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.
The Journal of experimental medicine
Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Mon Apr 05 00:00:00 EDT 2021
Romidepsin (FK228) regulates the expression of the immune checkpoint ligand PD-L1 and suppresses cellular immune functions in colon cancer.
Cancer immunology, immunotherapy : CII
Shi Y,Fu Y,Zhang X,Zhao G,Yao Y,Guo Y,Ma G,Bai S,Li H
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
The role of dendritic cells for therapy of B-cell lymphoma with immune checkpoint inhibitors.
Cancer immunology, immunotherapy : CII
Scheuerpflug A,Ahmetlić F,Bauer V,Riedel T,Röcken M,Mocikat R
14-0042 was used in Flow cytometry/Cell sorting to investigate the role of dendritic cells (DCs) for the therapeutic effect of ICB in a λ-MYC-transgenic mouse model of endogenously arising B-cell lymphoma.
Sat May 01 00:00:00 EDT 2021
Potential therapeutic effects of interleukin-35 on the differentiation of naïve T cells into Helios+Foxp3+ Tregs in clinical and experimental acute respiratory distress syndrome.
Molecular immunology
Wang C,Xie K,Li K,Lin S,Xu F
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2021
Anisakis pegreffii Extract Induces Airway Inflammation with Airway Remodeling in a Murine Model System.
BioMed research international
Choi JH,Kim JY,Yi MH,Kim M,Yong TS
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Wed Jan 12 00:00:00 EST 2022
Feline adipose tissue-derived mesenchymal stem cells pretreated with IFN-γ enhance immunomodulatory effects through the PGE₂ pathway.
Journal of veterinary science
Park SG,An JH,Li Q,Chae HK,Park SM,Lee JH,Ahn JO,Song WJ,Youn HY
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Mon Mar 01 00:00:00 EST 2021
Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice.
The Journal of international medical research
Li W,Luo Y,Xu H,Ma Q,Yao Q
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2021
Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation.
Theranostics
Chen L,Chen H,Ye J,Ge Y,Wang H,Dai E,Ren J,Liu W,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Wed Aug 04 00:00:00 EDT 2021
Tissue plasminogen activator worsens experimental autoimmune encephalomyelitis by complementary actions on lymphoid and myeloid cell responses.
Journal of neuroinflammation
Hélie P,Camacho-Toledano C,Lesec L,Seillier C,Miralles AJ,Ortega MC,Guérit S,Lebas H,Bardou I,Vila-Del Sol V,Vivien D,Le Mauff B,Clemente D,Docagne F,Toutirais O
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Immunohistochemistry
Sat Feb 20 00:00:00 EST 2021
Tissue plasminogen activator worsens experimental autoimmune encephalomyelitis by complementary actions on lymphoid and myeloid cell responses.
Journal of neuroinflammation
Hélie P,Camacho-Toledano C,Lesec L,Seillier C,Miralles AJ,Ortega MC,Guérit S,Lebas H,Bardou I,Vila-Del Sol V,Vivien D,Le Mauff B,Clemente D,Docagne F,Toutirais O
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Immunohistochemistry
Sat Feb 20 00:00:00 EST 2021
Antitumor efficacy of a neoantigen cancer vaccine delivered by electroporation is influenced by microbiota composition.
Oncoimmunology
Lione L,Salvatori E,Petrazzuolo A,Massacci A,Maggio R,Confroti A,Compagnone M,Aurisicchio L,Ciliberto G,Palombo F
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Tue Mar 23 00:00:00 EDT 2021
Evaluation of DNA-Launched Virus-Like Particle Vaccines in an Immune Competent Mouse Model of Chikungunya Virus Infection.
Vaccines
Rayner JO,Kim JH,Roberts RW,Wood RR,Fouty B,Solodushko V
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Fri Apr 02 00:00:00 EDT 2021
Increased Levels of IL-16 in the Central Nervous System during Neuroinflammation Are Associated with Infiltrating Immune Cells and Resident Glial Cells.
Biology
Hridi SU,Barbour M,Wilson C,Franssen AJ,Harte T,Bushell TJ,Jiang HR
14-0042-82 was used in Immunohistochemistry (Frozen) to investigate the correlation between interleukin 16 levels and neuroinflammation severity using an experimental autoimmune encephalomyelitis mouse model.
Thu May 27 00:00:00 EDT 2021
Increased Levels of IL-16 in the Central Nervous System during Neuroinflammation Are Associated with Infiltrating Immune Cells and Resident Glial Cells.
Biology
Hridi SU,Barbour M,Wilson C,Franssen AJ,Harte T,Bushell TJ,Jiang HR
14-0042-82 was used in Immunohistochemistry (Frozen) to investigate the correlation between interleukin 16 levels and neuroinflammation severity using an experimental autoimmune encephalomyelitis mouse model.
Thu May 27 00:00:00 EDT 2021
Gut Microbiota Dysbiosis Induced by Intracerebral Hemorrhage Aggravates Neuroinflammation in Mice.
Frontiers in microbiology
Yu X,Zhou G,Shao B,Zhou H,Xu C,Yan F,Wang L,Chen G,Li J,Fu X
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Wed May 26 00:00:00 EDT 2021
Epithelial Mutant p53 Promotes Resistance to Anti-PD-1-Mediated Oral Cancer Immunoprevention in Carcinogen-Induced Mouse Models.
Cancers
Wang J,Hu Y,Escamilla-Rivera V,Gonzalez CL,Tang L,Wang B,El-Naggar AK,Myers JN,Caulin C
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Immunohistochemistry
Tue Mar 23 00:00:00 EDT 2021
Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials.
EBioMedicine
Okada R,Furusawa A,Vermeer DW,Inagaki F,Wakiyama H,Kato T,Nagaya T,Choyke PL,Spanos WC,Allen CT,Kobayashi H
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Activation of Bone Marrow Adaptive Immunity in Type 2 Diabetes: Rescue by Co-stimulation Modulator Abatacept.
Frontiers in immunology
Santopaolo M,Sullivan N,Thomas AC,Alvino VV,Nicholson LB,Gu Y,Spinetti G,Kallikourdis M,Blom A,Madeddu P
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Fri Jul 02 00:00:00 EDT 2021
Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer.
Nature communications
Huang Y,Guan Z,Dai X,Shen Y,Wei Q,Ren L,Jiang J,Xiao Z,Jiang Y,Liu D,Huang Z,Xu X,Luo Y,Zhao C
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Wed Jul 14 00:00:00 EDT 2021
Histological, behavioural and flow cytometric datasets relating to acute ischaemic stroke in young, aged and ApoE-/- mice in the presence and absence of immunomodulation with fingolimod.
Data in brief
Diaz Diaz AC,Malone K,Shearer JA,Moore AC,Waeber C
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Tue Jun 01 00:00:00 EDT 2021
STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer.
Journal for immunotherapy of cancer
Lee SJ,Yang H,Kim WR,Lee YS,Lee WS,Kong SJ,Lee HJ,Kim JH,Cheon J,Kang B,Chon HJ,Kim C
14-0042-82 was used in Immunohistochemistry to elucidate the immune-evasion mechanisms during the peritoneal carcinomatosis of colon cancer and developed a novel immunotherapy by activating the stimulator of interferon genes (STING) pathway.
Tue Jun 01 00:00:00 EDT 2021
STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer.
Journal for immunotherapy of cancer
Lee SJ,Yang H,Kim WR,Lee YS,Lee WS,Kong SJ,Lee HJ,Kim JH,Cheon J,Kang B,Chon HJ,Kim C
14-0042-82 was used in Immunohistochemistry to elucidate the immune-evasion mechanisms during the peritoneal carcinomatosis of colon cancer and developed a novel immunotherapy by activating the stimulator of interferon genes (STING) pathway.
Tue Jun 01 00:00:00 EDT 2021
Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death.
Frontiers in immunology
Yang L,Chen W,Li L,Xiao Y,Fan S,Zhang Q,Xia T,Li M,Hong Y,Zhao T,Li Q,Liu WH,Xiao N
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Mon Dec 20 00:00:00 EST 2021
Local Sustained GM-CSF Delivery by Genetically Engineered Encapsulated Cells Enhanced Both Cellular and Humoral SARS-CoV-2 Spike-Specific Immune Response in an Experimental Murine Spike DNA Vaccination Model.
Vaccines
Vernet R,Charrier E,Cosset E,Fièvre S,Tomasello U,Grogg J,Mach N
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Mon May 10 00:00:00 EDT 2021
Sequencing, cloning, and antigen binding analysis of monoclonal antibodies isolated from single mouse B cells.
STAR protocols
Viant C,Escolano A,Chen ST,Nussenzweig MC
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Fri Jun 18 00:00:00 EDT 2021
Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis.
Journal of neuroinflammation
Chen YH,Eskandarpour M,Zhang X,Galatowicz G,Greenwood J,Lightman S,Calder V
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Thu Feb 18 00:00:00 EST 2021
Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.
STAR protocols
Skordos I,Demeyer A,Beyaert R
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Fri Mar 19 00:00:00 EDT 2021
Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers.
PloS one
Cohen AA,Yang Z,Gnanapragasam PNP,Ou S,Dam KA,Wang H,Bjorkman PJ
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Fri Oct 15 00:00:00 EDT 2021
Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease.
Cell
Lee JY,Hall JA,Kroehling L,Wu L,Najar T,Nguyen HH,Lin WY,Yeung ST,Silva HM,Li D,Hine A,Loke P,Hudesman D,Martin JC,Kenigsberg E,Merad M,Khanna KM,Littman DR
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Immunocytochemistry
Thu Jan 09 00:00:00 EST 2020
Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity.
The Journal of clinical investigation
Webb LM,Sengupta S,Edell C,Piedra-Quintero ZL,Amici SA,Miranda JN,Bevins M,Kennemer A,Laliotis G,Tsichlis PN,Guerau-de-Arellano M
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
High-dose vitamin C enhances cancer immunotherapy.
Science translational medicine
Magrì A,Germano G,Lorenzato A,Lamba S,Chilà R,Montone M,Amodio V,Ceruti T,Sassi F,Arena S,Abrignani S,D'Incalci M,Zucchetti M,Di Nicolantonio F,Bardelli A
14-0042-82 was used in Immunohistochemistry to provide a rationale for clinical trials combining ICT with high doses of VitC.
Wed Feb 26 00:00:00 EST 2020
hnRNPU/TrkB Defines a Chromatin Accessibility Checkpoint for Liver Injury and Nonalcoholic Steatohepatitis Pathogenesis.
Hepatology (Baltimore, Md.)
Xiong J,Liu T,Mi L,Kuang H,Xiong X,Chen Z,Li S,Lin JD
14-0042-82 was used in Immunohistochemistry (Paraffin) to show that heterogeneous nuclear ribonucleoprotein U (hnRNPU), a nuclear matrix protein that governs chromatin architecture and gene transcription, is a critical factor that couples chromatin disruption to NASH pathogenesis.
Wed Apr 01 00:00:00 EDT 2020
Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function.
Proceedings of the National Academy of Sciences of the United States of America
Shime H,Odanaka M,Tsuiji M,Matoba T,Imai M,Yasumizu Y,Uraki R,Minohara K,Watanabe M,Bonito AJ,Fukuyama H,Ohkura N,Sakaguchi S,Morita A,Yamazaki S
14-0042-82 was used in Flow Cytometry to report a feature of skin Treg cells expanded by ultraviolet B (UVB) exposure.
Tue Aug 25 00:00:00 EDT 2020
Inflammation shapes pathogenesis of murine arrhythmogenic cardiomyopathy.
Basic research in cardiology
Lubos N,van der Gaag S,Gerçek M,Kant S,Leube RE,Krusche CA
14-0042 was used in Immunohistochemistry to investigate if specific immune cell populations and chemokine expression profiles modulate inflammatory and repair processes throughout arrhythmogenic cardiomyopathy progression.
Fri Jun 12 00:00:00 EDT 2020
Methnaridine is an orally bioavailable, fast-killing and long-acting antimalarial agent that cures Plasmodium infections in mice.
British journal of pharmacology
Wang W,Yao J,Chen Z,Sun Y,Shi Y,Wei Y,Zhou H,Yu Y,Li S,Duan L
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2020
DKK2 blockage-mediated immunotherapy enhances anti-angiogenic therapy of Kras mutated colorectal cancer.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Hu J,Wang Z,Chen Z,Li A,Sun J,Zheng M,Wu J,Shen T,Qiao J,Li L,Li B,Wu D,Xiao Q
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Wed Jul 01 00:00:00 EDT 2020
Inhibition of IDO leads to IL-6-dependent systemic inflammation in mice when combined with photodynamic therapy.
Cancer immunology, immunotherapy : CII
Wachowska M,Stachura J,Tonecka K,Fidyt K,Braniewska A,Sas Z,Kotula I,Rygiel TP,Boon L,Golab J,Muchowicz A
14-0042-82 was used in Flow Cytometry to investigate the antitumor potential of photodynamic therapy combined with indoleamine 2,3-dioxygenase 1 inhibitor in the murine 4T1 and E0771 orthotopic breast cancer models.
Mon Jun 01 00:00:00 EDT 2020
Senescence-associated secretory phenotype promotes chronic ocular graft-vs-host disease in mice and humans.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Yamane M,Sato S,Shimizu E,Shibata S,Hayano M,Yaguchi T,Kamijuku H,Ogawa M,Suzuki T,Mukai S,Shimmura S,Okano H,Takeuchi T,Kawakami Y,Ogawa Y,Tsubota K
14-0042-82 was used in Immunohistochemistry to elucidate an additional pathway of chronic ocular chronic graft-vs-host disease.
Sat Aug 01 00:00:00 EDT 2020
T-B Lymphocyte Interactions Promote Type 1 Diabetes Independently of SLAM-Associated Protein.
Journal of immunology (Baltimore, Md. : 1950)
Bonami RH,Nyhoff LE,McNitt DH,Hulbert C,Felton JL,Kendall PL,Thomas JW
14-0042-82 was used in Flow Cytometry to understand how fully developed T follicular helper cells contribute to different autoimmune processes, investigating the role of signaling lymphocytic activation molecule-associated protein in type 1 diabetes and autoantibody-mediated arthritis.
Tue Dec 15 00:00:00 EST 2020
Increased Tim-3 expression on TILs during treatment with the Anchored GM-CSF vaccine and anti-PD-1 antibodies is inversely correlated with response in prostate cancer.
Journal of Cancer
Zhang X,Chen H,Li G,Zhou X,Shi Y,Zou F,Chen Y,Gao J,Yang S,Wu S,Long Z
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Wed Sep 30 00:00:00 EDT 2020
Comparison of rapamycin and methylprednisolone for treating inflammatory muscle disease in a murine model of experimental autoimmune myositis.
Experimental and therapeutic medicine
Kang J,Feng D,Yang F,Tian X,Han W,Jia H
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Wed Jul 01 00:00:00 EDT 2020
Effects of CD4+ T lymphocytes from ovariectomized mice on bone marrow mesenchymal stem cell proliferation and osteogenic differentiation.
Experimental and therapeutic medicine
Shao BY,Wang L,Yu Y,Chen L,Gan N,Huang WM
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Sun Nov 01 00:00:00 EDT 2020
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Nature communications
Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Thu Sep 17 00:00:00 EDT 2020
Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety.
Journal for immunotherapy of cancer
Ge Y,Wang H,Ren J,Liu W,Chen L,Chen H,Ye J,Dai E,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Sun Mar 01 00:00:00 EST 2020
A novel antibody targeting TIM-3 resulting in receptor internalization for cancer immunotherapy.
Antibody therapeutics
Kuang Z,Li L,Zhang P,Chen B,Wu M,Ni H,Yi S,Zou J,Liu J
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2020
Angioimmunoblastic T-cell lymphoma-like lymphadenopathy in mice transgenic for human RHOA with p.Gly17Val mutation.
Oncoimmunology
Lee GJ,Jun Y,Yoo HY,Jeon YK,Lee D,Lee S,Kim J
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Immunohistochemistry (Paraffin)
Wed May 13 00:00:00 EDT 2020
Angioimmunoblastic T-cell lymphoma-like lymphadenopathy in mice transgenic for human RHOA with p.Gly17Val mutation.
Oncoimmunology
Lee GJ,Jun Y,Yoo HY,Jeon YK,Lee D,Lee S,Kim J
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Immunohistochemistry (Paraffin)
Wed May 13 00:00:00 EDT 2020
Mechanisms of interleukin 4 mediated increase in efficacy of vaccines against opioid use disorders.
NPJ vaccines
Crouse B,Robinson C,Huseby Kelcher A,Laudenbach M,Abrahante JE,Pravetoni M
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Thu Oct 29 00:00:00 EDT 2020
CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation.
Frontiers in immunology
Shapiro MR,Yeh WI,Longfield JR,Gallagher J,Infante CM,Wellford S,Posgai AL,Atkinson MA,Campbell-Thompson M,Lieberman SM,Serreze DV,Geurts AM,Chen YG,Brusko TM
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Wed May 26 00:00:00 EDT 2021
Distinct actions of the fermented beverage kefir on host behaviour, immunity and microbiome gut-brain modules in the mouse.
Microbiome
van de Wouw M,Walsh AM,Crispie F,van Leuven L,Lyte JM,Boehme M,Clarke G,Dinan TG,Cotter PD,Cryan JF
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Mon May 18 00:00:00 EDT 2020
Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation.
Nature communications
Iske J,Seyda M,Heinbokel T,Maenosono R,Minami K,Nian Y,Quante M,Falk CS,Azuma H,Martin F,Passos JF,Niemann CU,Tchkonia T,Kirkland JL,Elkhal A,Tullius SG
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Thu Aug 27 00:00:00 EDT 2020
Loss of testosterone impairs anti-tumor neutrophil function.
Nature communications
Markman JL,Porritt RA,Wakita D,Lane ME,Martinon D,Noval Rivas M,Luu M,Posadas EM,Crother TR,Arditi M
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Tue Mar 31 00:00:00 EDT 2020
Positive Effects of Preventive Nutrition Supplement on Anticancer Radiotherapy in Lung Cancer Bearing Mice.
Cancers
Liu YM,Wu TH,Chiu YH,Wang H,Li TL,Hsia S,Chan YL,Wu CJ
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Immunohistochemistry
Fri Aug 28 00:00:00 EDT 2020
Positive Effects of Preventive Nutrition Supplement on Anticancer Radiotherapy in Lung Cancer Bearing Mice.
Cancers
Liu YM,Wu TH,Chiu YH,Wang H,Li TL,Hsia S,Chan YL,Wu CJ
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Immunohistochemistry
Fri Aug 28 00:00:00 EDT 2020
Prodrug-Loaded Zirconium Carbide Nanosheets as a Novel Biophotonic Nanoplatform for Effective Treatment of Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Liu Q,Xie Z,Qiu M,Shim I,Yang Y,Xie S,Yang Q,Wang D,Chen S,Fan T,Ding B,Guo Z,Adah D,Yao X,Zhang Y,Wu H,Wu Z,Wei C,Wang H,Kim HS,Zou Q,Yan Q,Cai Z,Kim JS,Liu LP,Zhang H,Cao Y
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Immunohistochemistry
Tue Dec 01 00:00:00 EST 2020
STING couples with PI3K to regulate actin reorganization during BCR activation.
Science advances
Jing Y,Dai X,Yang L,Kang D,Jiang P,Li N,Cheng J,Li J,Miller H,Ren B,Gong Q,Yin W,Liu Z,Mattila PK,Ning Q,Sun J,Yu B,Liu C
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Immunohistochemistry
Wed Apr 01 00:00:00 EDT 2020
A Commercial Probiotic Induces Tolerogenic and Reduces Pathogenic Responses in Experimental Autoimmune Encephalomyelitis.
Cells
Calvo-Barreiro L,Eixarch H,Ponce-Alonso M,Castillo M,Lebrón-Galán R,Mestre L,Guaza C,Clemente D,Del Campo R,Montalban X,Espejo C
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Tue Apr 07 00:00:00 EDT 2020
Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma.
Journal for immunotherapy of cancer
Shigeta K,Matsui A,Kikuchi H,Klein S,Mamessier E,Chen IX,Aoki S,Kitahara S,Inoue K,Shigeta A,Hato T,Ramjiawan RR,Staiculescu D,Zopf D,Fiebig L,Hobbs GS,Quaas A,Dima S,Popescu I,Huang P,Munn LL,Cobbold M,Goyal L,Zhu AX,Jain RK,Duda DG
14-0042-82 was used in Flow Cytometry to conclude that judicious regorafenib/anti-PD1 combination therapy can inhibit tumor growth and increase survival by normalizing tumor vasculature and increasing intratumoral CXCR3+CD8 T-cell infiltration through elevated CXCL10 expression in HCC cells.
Sun Nov 01 00:00:00 EDT 2020
Axenic Caenorhabditis elegans antigen protects against development of type-1 diabetes in NOD mice.
Journal of translational autoimmunity
Jackson-Thompson BM,Torrero M,Mitre BK,Long J,Packiam M,Mitre E
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Mon Sep 28 00:00:00 EDT 2020
TH17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity.
Science immunology
Harbour SN,DiToro DF,Witte SJ,Zindl CL,Gao M,Schoeb TR,Jones GW,Jones SA,Hatton RD,Weaver CT
14-0042-82 was used in Flow Cytometry to find that IL-6 signaling is required for both induction and maintenance of mouse TH17 cells; IL-6Rα-deficient TH17 cells rapidly lost their TH17 phenotype and did not cause disease in two models of colitis.
Fri Jul 17 00:00:00 EDT 2020
Commensal Microbiota Promote Lung Cancer Development via γδ T Cells.
Cell
Jin C,Lagoudas GK,Zhao C,Bullman S,Bhutkar A,Hu B,Ameh S,Sandel D,Liang XS,Mazzilli S,Whary MT,Meyerson M,Germain R,Blainey PC,Fox JG,Jacks T
14-0042-82 was used in Flow Cytometry to link local microbiota-immune crosstalk to lung tumor development and thereby define key cellular and molecular mediators that may serve as effective targets in lung cancer intervention.
Thu Feb 21 00:00:00 EST 2019
T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation.
Immunity
Fu YY,Egorova A,Sobieski C,Kuttiyara J,Calafiore M,Takashima S,Clevers H,Hanash AM
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Immunocytochemistry
Tue Jul 16 00:00:00 EDT 2019
T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation.
Immunity
Fu YY,Egorova A,Sobieski C,Kuttiyara J,Calafiore M,Takashima S,Clevers H,Hanash AM
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Immunocytochemistry
Tue Jul 16 00:00:00 EDT 2019
The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy.
Cellular & molecular immunology
Moschovakis GL,Bubke A,Friedrichsen M,Ristenpart J,Back JW,Falk CS,Kremmer E,Förster R
14-0042-82 was used in Flow Cytometry to demonstrate that CCR7 signaling is essential for the induction of CIA and identify CCR7 as a potential therapeutic target in RA.
Tue Oct 01 00:00:00 EDT 2019
Inhibition of T cell activation and function by the adaptor protein CIN85.
Science signaling
Kong MS,Hashimoto-Tane A,Kawashima Y,Sakuma M,Yokosuka T,Kometani K,Onishi R,Carpino N,Ohara O,Kurosaki T,Phua KK,Saito T
14-0042-82 was used in Flow Cytometry to show that CIN85 (Cbl-interacting protein of 85 kDa) limited T cell responses to T cell receptor stimulation.
Tue Feb 05 00:00:00 EST 2019
Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice.
Genome research
Alriyami M,Marchand L,Li Q,Du X,Olivier M,Polychronakos C
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Sun Dec 01 00:00:00 EST 2019
MicroRNA-21 is Required for Hematopoietic Cell Viability After Radiation Exposure.
International journal of radiation oncology, biology, physics
Puccetti MV,Adams CM,Dan TD,Palagani A,Simone BA,DeAngelis T,Eischen CM,Simone NL
14-0042 was used in Flow cytometry/Cell sorting to identify miR-21 as a critical component of HSPC viability and essential for bone marrow recovery following irradiation. Further investigation is warranted to determine whether miR-21 can be used to stratify patients at risk for hematopoietic toxicity following irradiation.
Thu Aug 01 00:00:00 EDT 2019
A JAK1 Selective Kinase Inhibitor and Tofacitinib Affect Macrophage Activation and Function.
Inflammatory bowel diseases
De Vries LCS,Duarte JM,De Krijger M,Welting O,Van Hamersveld PHP,Van Leeuwen-Hilbers FWM,Moerland PD,Jongejan A,D'Haens GR,De Jonge WJ,Wildenberg ME
14-0042 was used in Flow cytometry/Cell sorting to study the potential of tofacitinib to affect macrophage activation.
Thu Mar 14 00:00:00 EDT 2019
Critical Adverse Impact of IL-6 in Acute Pneumovirus Infection.
Journal of immunology (Baltimore, Md. : 1950)
Percopo CM,Ma M,Brenner TA,Krumholz JO,Break TJ,Laky K,Rosenberg HF
14-0042 was used in Flow cytometry/Cell sorting to examine the role of the pleiotropic cytokine IL-6 in acute infection with pneumonia virus of mice.
Fri Feb 01 00:00:00 EST 2019
Interleukin-16 inhibits sodium channel function and GluA1 phosphorylation via CD4- and CD9-independent mechanisms to reduce hippocampal neuronal excitability and synaptic activity.
Molecular and cellular neurosciences
Hridi SU,Franssen AJPM,Jiang HR,Bushell TJ
14-0042-82 was used in Immunocytochemistry to investigate whether interleukin 16 modulates neuronal excitability and synaptic activity in mouse primary hippocampal cultures.
Fri Mar 01 00:00:00 EST 2019
A unique mutator phenotype reveals complementary oncogenic lesions leading to acute leukemia.
JCI insight
Yin M,Baslan T,Walker RL,Zhu YJ,Freeland A,Matsukawa T,Sridharan S,Nussenzweig A,Pruitt SC,Lowe SW,Meltzer PS,Aplan PD
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Thu Dec 05 00:00:00 EST 2019
Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte Dysfunction.
Frontiers in immunology
Fenninger F,Han J,Stanwood SR,Nohara LL,Arora H,Choi KB,Munro L,Pfeifer CG,Shanina I,Horwitz MS,Jefferies WA
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Thu Oct 29 00:00:00 EDT 2020
Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis.
Scientific reports
Brichacek AL,Benkovic SA,Chakraborty S,Nwafor DC,Wang W,Jun S,Dakhlallah D,Geldenhuys WJ,Pinkerton AB,Millán JL,Brown CM
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Wed Dec 11 00:00:00 EST 2019
Chloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases.
Scientific reports
Park TY,Jang Y,Kim W,Shin J,Toh HT,Kim CH,Yoon HS,Leblanc P,Kim KS
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Tue Oct 29 00:00:00 EDT 2019
Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR.
Nature communications
Zhu H,Bhatt B,Sivaprakasam S,Cai Y,Liu S,Kodeboyina SK,Patel N,Savage NM,Sharma A,Kaufman RJ,Li H,Singh N
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Wed Mar 06 00:00:00 EST 2019
Mucin O-glycans facilitate symbiosynthesis to maintain gut immune homeostasis.
EBioMedicine
Yamada T,Hino S,Iijima H,Genda T,Aoki R,Nagata R,Han KH,Hirota M,Kinashi Y,Oguchi H,Suda W,Furusawa Y,Fujimura Y,Kunisawa J,Hattori M,Fukushima M,Morita T,Hase K
14-0042 was used in Flow cytometry/Cell sorting to propose that abnormal mucin utilisation may lead to reduced n-butyrate production in ulcerative colitis patients and that mucin o-glycans can facilitate symbiosynthesis of n-butyrate by gut microbiota.
Tue Oct 01 00:00:00 EDT 2019
Escherichia coli limits Salmonella Typhimurium infections after diet shifts and fat-mediated microbiota perturbation in mice.
Nature microbiology
Wotzka SY,Kreuzer M,Maier L,Arnoldini M,Nguyen BD,Brachmann AO,Berthold DL,Zünd M,Hausmann A,Bakkeren E,Hoces D,Gül E,Beutler M,Dolowschiak T,Zimmermann M,Fuhrer T,Moor K,Sauer U,Typas A,Piel J,Diard M,Macpherson AJ,Stecher B,Sunagawa S,Slack E,Hardt WD
14-0042-82 was used in Flow Cytometry to determine whether food composition shifts enhance susceptibility to infection as diet affects microbiota composition.
Sun Dec 01 00:00:00 EST 2019
CD4+ and CD8a+ PET imaging predicts response to novel PD-1 checkpoint inhibitor: studies of Sym021 in syngeneic mouse cancer models.
Theranostics
Kristensen LK,Fröhlich C,Christensen C,Melander MC,Poulsen TT,Galler GR,Lantto J,Horak ID,Kragh M,Nielsen CH,Kjaer A
14-0042 was used in Immunohistochemistry to develop radio-tracers, for detection and assessment of whole body CD4+ and CD8a+ status, in order to predict responses of tumours to an immune checkpoint inhibitor.
Fri Aug 28 00:00:00 EDT 2020
Inducible IL-7 Hyperexpression Influences Lymphocyte Homeostasis and Function and Increases Allograft Rejection.
Frontiers in immunology
Schreiber M,Weigelt M,Karasinsky A,Anastassiadis K,Schallenberg S,Petzold C,Bonifacio E,Kretschmer K,Hommel A
14-0042 was used in Flow cytometry/Cell sorting to show that transient hyperexpression of IL-7 can impair immune regulation, through disturbances in lymphocyte development pathways, and decrease graft survival time, even under immunosuppression.
Mon Sep 14 00:00:00 EDT 2020
Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis.
Nature communications
Lee HG,Lee JU,Kim DH,Lim S,Kang I,Choi JM
14-0042 was used in Flow cytometry/Cell sorting to reveal the innate-like pathogenic function of antigen non-related memory CD4+ T cells, which contribute to the development of autoimmune diseases.
Tue Feb 12 00:00:00 EST 2019
Female and male mouse lung group 2 innate lymphoid cells differ in gene expression profiles and cytokine production.
PloS one
Mathä L,Shim H,Steer CA,Yin YH,Martinez-Gonzalez I,Takei F
14-0042-82 was used in Flow Cytometry to suggest that female ILC2s are more readily activated than male ILC2s due to their gene expression at the naïve state, which is potentially influenced by the lung environment.
Mon Dec 16 00:00:00 EST 2019
Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice.
Nature
Que X,Hung MY,Yeang C,Gonen A,Prohaska TA,Sun X,Diehl C,Määttä A,Gaddis DE,Bowden K,Pattison J,MacDonald JG,Ylä-Herttuala S,Mellon PL,Hedrick CC,Ley K,Miller YI,Glass CK,Peterson KL,Binder CJ,Tsimikas S,Witztum JL
14-0042 was used in Flow cytometry/Cell sorting to determine the role of oxidised phospholipids in atherogenesis within transgenic mice.
Fri Jun 01 00:00:00 EDT 2018
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Cell
Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Thu Jun 28 00:00:00 EDT 2018
T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation.
Immunity
Shimada K,Porritt RA,Markman JL,O'Rourke JG,Wakita D,Noval Rivas M,Ogawa C,Kozhaya L,Martins GA,Unutmaz D,Baloh RH,Crother TR,Chen S,Arditi M
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Tue Nov 20 00:00:00 EST 2018
TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4+CD8+ thymocytes.
Nature immunology
Emmanuel AO,Arnovitz S,Haghi L,Mathur PS,Mondal S,Quandt J,Okoreeh MK,Maienschein-Cline M,Khazaie K,Dose M,Gounari F
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Sat Dec 01 00:00:00 EST 2018
Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5.
The Journal of experimental medicine
Buxadé M,Huerga Encabo H,Riera-Borrull M,Quintana-Gallardo L,López-Cotarelo P,Tellechea M,Martínez-Martínez S,Redondo JM,Martín-Caballero J,Flores JM,Bosch E,Rodríguez-Fernández JL,Aramburu J,López-Rodríguez C
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Mon Nov 05 00:00:00 EST 2018
Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cells.
The Journal of experimental medicine
Seki A,Rutz S
14-0042 was used in Flow cytometry/Cell sorting to develop an optimised approach for Cas9/RNP transfection of primary mouse and human T cells without TCR stimulation, that results in near complete loss of target gene expression at the population level.
Mon Mar 05 00:00:00 EST 2018
IL-7-dependent maintenance of ILC3s is required for normal entry of lymphocytes into lymph nodes.
The Journal of experimental medicine
Yang J,Cornelissen F,Papazian N,Reijmers RM,Llorian M,Cupedo T,Coles M,Seddon B
14-0042 was used in Flow cytometry/Cell sorting to investigate whether continued IL-7 expression was required for the maintenance of fully developed, adult lymph nodes.
Mon Apr 02 00:00:00 EDT 2018
Bryostatin-1 alleviates experimental multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America
Kornberg MD,Smith MD,Shirazi HA,Calabresi PA,Snyder SH,Kim PM
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Tue Feb 27 00:00:00 EST 2018
Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress.
PLoS biology
Mensurado S,Rei M,Lança T,Ioannou M,Gonçalves-Sousa N,Kubo H,Malissen M,Papayannopoulos V,Serre K,Silva-Santos B
14-0042 was used in Flow cytometry/Cell sorting to study the role of tumour-associated neutrophils in the regulation of γδ17 T-cell responses in the tumour microenvironment.
Tue May 01 00:00:00 EDT 2018
Quantitative Methods for Measuring Repair Rates and Innate-Immune Cell Responses in Wounded Mouse Skin.
Frontiers in immunology
Li Z,Gothard E,Coles MC,Ambler CA
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Wed Mar 27 00:00:00 EDT 2019
Induction of Cytotoxic T-Lymphocyte Responses Upon Subcutaneous Administration of a Subunit Vaccine Adjuvanted With an Emulsion Containing the Toll-Like Receptor 3 Ligand Poly(I:C).
Frontiers in immunology
Schmidt ST,Pedersen GK,Neustrup MA,Korsholm KS,Rades T,Andersen P,Foged C,Christensen D
14-0042 was used in Flow cytometry/Cell sorting to cAF24a is a promising adjuvant for induction of CTL responses upon s.c. and i.m. immunization.
Mon Jun 10 00:00:00 EDT 2019
Programmed Cell Death Protein 1-PDL1 Interaction Prevents Heart Damage in Chronic Trypanosoma cruzi Infection.
Frontiers in immunology
Fonseca R,Salgado RM,Borges da Silva H,do Nascimento RS,D'Império-Lima MR,Alvarez JM
14-0042 was used in Immunohistochemistry-immunofluorescence to suggest PD1-PDL1 interaction protects the heart from excessive immune response.
Thu Jul 11 00:00:00 EDT 2019
Programmed Cell Death Protein 1-PDL1 Interaction Prevents Heart Damage in Chronic Trypanosoma cruzi Infection.
Frontiers in immunology
Fonseca R,Salgado RM,Borges da Silva H,do Nascimento RS,D'Império-Lima MR,Alvarez JM
14-0042 was used in Immunohistochemistry-immunofluorescence to suggest PD1-PDL1 interaction protects the heart from excessive immune response.
Thu Jul 11 00:00:00 EDT 2019
Protease-activated receptor-2 signaling through β-arrestin-2 mediates Alternaria alkaline serine protease-induced airway inflammation.
American journal of physiology. Lung cellular and molecular physiology
Yee MC,Nichols HL,Polley D,Saifeddine M,Pal K,Lee K,Wilson EH,Daines MO,Hollenberg MD,Boitano S,DeFea KA
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Sat Dec 01 00:00:00 EST 2018
Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice.
Journal of neuroimmunology
Kiyota T,Machhi J,Lu Y,Dyavarshetty B,Nemati M,Yokoyama I,Mosley RL,Gendelman HE
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Fri Jun 15 00:00:00 EDT 2018
Immunological effects of a low-dose cytarabine, aclarubicin and granulocyte-colony stimulating factor priming regimen on a mouse leukemia model.
Oncology letters
Chen J,Yang N,Liu H,Yao H,Wang J,Yang Y,Zhang W
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2018
Protective function of Bu Shen Huo Xue formula on the immunity of B6AF1 mice with experimental autoimmune premature ovarian failure.
Experimental and therapeutic medicine
Wang P,Lu Y,Chen S,Chen Y,Hu C,Zuo Y
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Sun Apr 01 00:00:00 EDT 2018
Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene.
Nature communications
Kojo S,Yasmin N,Muroi S,Tenno M,Taniuchi I
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Wed Sep 05 00:00:00 EDT 2018
Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2.
Nature communications
Liu Z,Ge Y,Wang H,Ma C,Feist M,Ju S,Guo ZS,Bartlett DL
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Thu Nov 08 00:00:00 EST 2018
Rap1 deficiency-provoked paracrine dysfunction impairs immunosuppressive potency of mesenchymal stem cells in allograft rejection of heart transplantation.
Cell death & disease
Ding Y,Liang X,Zhang Y,Yi L,Shum HC,Chen Q,Chan BP,Fan H,Liu Z,Tergaonkar V,Qi Z,Tse HF,Lian Q
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Wed Mar 07 00:00:00 EST 2018
A Type I Interferon and IL-10 Induced by Orientia tsutsugamushi Infection Suppresses Antigen-Specific T Cells and Their Memory Responses.
Frontiers in immunology
Min CK,Kim HI,Ha NY,Kim Y,Kwon EK,Yen NTH,Youn JI,Jeon YK,Inn KS,Choi MS,Cho NH
14-0042 was used in Flow cytometry/Cell sorting to show that the induction of the type I IFN/IL-10 axis by O. tsutsugamushi infection might play a significant role in the suppression of T cell responses and contribute to the short longevity of cell-mediated immunity, often observed in scrub typhus patients.
Mon Sep 30 00:00:00 EDT 2019
CCL7 Is a Negative Regulator of Cutaneous Inflammation Following Leishmania major Infection.
Frontiers in immunology
Ford J,Hughson A,Lim K,Bardina SV,Lu W,Charo IF,Lim JK,Fowell DJ
14-0042 was used in Flow cytometry/Cell sorting to determine the role of CCL7 in Leishmania major infection.
Mon Oct 21 00:00:00 EDT 2019
Eosinophils support adipocyte maturation and promote glucose tolerance in obesity.
Scientific reports
Lee EH,Itan M,Jang J,Gu HJ,Rozenberg P,Mingler MK,Wen T,Yoon J,Park SY,Roh JY,Choi CS,Park WJ,Munitz A,Jung Y
14-0042 was used in Flow cytometry/Cell sorting to propose that obesity promotes the infiltration of eosinophils into adipose tissue that subsequently contribute to the metabolic homeostasis by promoting adipocyte maturation.
Mon Jul 02 00:00:00 EDT 2018
Respiratory Bordetella bronchiseptica Carriage is Associated with Broad Phenotypic Alterations of Peripheral CD4⁺CD25⁺ T Cells and Differentially Affects Immune Responses to Secondary Non-Infectious and Infectious Stimuli in Mice.
International journal of molecular sciences
Jeron A,Boehme JD,Volckmar J,Gereke M,Yevsa T,Geffers R,Guzmán CA,Schreiber J,Stegemann-Koniszewski S,Bruder D
14-0042 was used in Flow cytometry/Cell sorting to study the effects of respiratory bacterial carriage on the immune system and its implications for secondary responses.
Sat Sep 01 00:00:00 EDT 2018
Functional characterization of oxazolone-induced colitis and survival improvement by vagus nerve stimulation.
PloS one
Meroni E,Stakenborg N,Gomez-Pinilla PJ,De Hertogh G,Goverse G,Matteoli G,Verheijden S,Boeckxstaens GE
14-0042 was used in Flow cytometry/Cell sorting to characterise the immune response in oxazolone-induced colitis and study the therapeutic effect of vagus nerve stimulation.
Tue Nov 27 00:00:00 EST 2018
2-AG limits Theiler's virus induced acute neuroinflammation by modulating microglia and promoting MDSCs.
Glia
Mecha M,Feliú A,Machín I,Cordero C,Carrillo-Salinas F,Mestre L,Hernández-Torres G,Ortega-Gutiérrez S,López-Rodríguez ML,de Castro F,Clemente D,Guaza C
14-0042-82 was used in Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Neutralization to suggest a robust modulatory effect in the peripheral and central immunity by 2-AG and highlight the interest of modulating endogenous cannabinoids to regulate CNS inflammatory conditions.
Sun Jul 01 00:00:00 EDT 2018
2-AG limits Theiler's virus induced acute neuroinflammation by modulating microglia and promoting MDSCs.
Glia
Mecha M,Feliú A,Machín I,Cordero C,Carrillo-Salinas F,Mestre L,Hernández-Torres G,Ortega-Gutiérrez S,López-Rodríguez ML,de Castro F,Clemente D,Guaza C
14-0042-82 was used in Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Neutralization to suggest a robust modulatory effect in the peripheral and central immunity by 2-AG and highlight the interest of modulating endogenous cannabinoids to regulate CNS inflammatory conditions.
Sun Jul 01 00:00:00 EDT 2018
A disconnect between precursor frequency, expansion potential, and site-specific CD4+ T cell responses in aged mice.
PloS one
Deshpande NR,Uhrlaub JL,Way SS,Nikolich-Žugich J,Kuhns MS
14-0042 was used in Flow cytometry/Cell sorting to explore if CD4+ T cell responses to immunization or infection increase with aging.
Tue Dec 11 00:00:00 EST 2018
Calcineurin-mediated IL-2 production by CD11chighMHCII+ myeloid cells is crucial for intestinal immune homeostasis.
Nature communications
Mencarelli A,Khameneh HJ,Fric J,Vacca M,El Daker S,Janela B,Tang JP,Nabti S,Balachander A,Lim TS,Ginhoux F,Ricciardi-Castagnoli P,Mortellaro A
14-0042 was used in Flow cytometry/Cell sorting to show that mice lacking Calcineurin B in CD11chighMHCII+ cells spontaneously develop intestinal inflammation and are susceptible to induced colitis.
Fri Mar 16 00:00:00 EDT 2018
Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance.
Nature immunology
Minguet S,Kläsener K,Schaffer AM,Fiala GJ,Osteso-Ibánez T,Raute K,Navarro-Lérida I,Hartl FA,Seidl M,Reth M,Del Pozo MA
14-0042 was used in Flow cytometry/Cell sorting to study the role of Caveolin-1 in controlling the distribution of nanoclusters of isotype-specific B cell antigen receptors on the surface of B cells.
Sun Oct 01 00:00:00 EDT 2017
The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage.
Nature immunology
Shan Q,Zeng Z,Xing S,Li F,Hartwig SM,Gullicksrud JA,Kurup SP,Van Braeckel-Budimir N,Su Y,Martin MD,Varga SM,Taniuchi I,Harty JT,Peng W,Badovinac VP,Xue HH
14-0042 was used in Flow cytometry/Cell sorting to show that Runx3-mediated Tcf7 repression coordinately enforced acquisition of cytotoxic functions and protected the cytotoxic lineage integrity by preventing TFH-lineage deviation.
Tue Aug 01 00:00:00 EDT 2017
A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens.
The Journal of clinical investigation
Sindhava VJ,Oropallo MA,Moody K,Naradikian M,Higdon LE,Zhou L,Myles A,Green N,Nündel K,Stohl W,Schmidt AM,Cao W,Dorta-Estremera S,Kambayashi T,Marshak-Rothstein A,Cancro MP
14-0042 was used in Flow cytometry/Cell sorting to describe a relationship among the B cell receptor, TLR9, and cytokine signals that regulate B cell responses to DNA-containing antigens.
Mon May 01 00:00:00 EDT 2017
Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment.
The Journal of clinical investigation
Wang YT,Chen J,Chang CW,Jen J,Huang TY,Chen CM,Shen R,Liang SY,Cheng IC,Yang SC,Lai WW,Cheng KH,Hsieh TS,Lai MZ,Cheng HC,Wang YC,Chen RH
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2017
Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.
The Journal of clinical investigation
Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2017
Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction.
The Journal of clinical investigation
Ramjee V,Li D,Manderfield LJ,Liu F,Engleka KA,Aghajanian H,Rodell CB,Lu W,Ho V,Wang T,Li L,Singh A,Cibi DM,Burdick JA,Singh MK,Jain R,Epstein JA
14-0042 was used in Flow cytometry to suggest that epicardial Hippo signalling plays a key role in adaptive immune regulation during the post-myocardial infarction recovery phase.
Wed Mar 01 00:00:00 EST 2017
MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation.
The Journal of experimental medicine
Singh PB,Pua HH,Happ HC,Schneider C,von Moltke J,Locksley RM,Baumjohann D,Ansel KM
14-0042 was used in Flow cytometry/Cell sorting to establish the physiological requirements for miRNAs in ILC2 homeostasis and immune function ans compare the global miRNA repertoire of resting and activated ILC2s and T helper type 2 cells.
Mon Dec 04 00:00:00 EST 2017
IL-36 Signaling Facilitates Activation of the NLRP3 Inflammasome and IL-23/IL-17 Axis in Renal Inflammation and Fibrosis.
Journal of the American Society of Nephrology : JASN
Chi HH,Hua KF,Lin YC,Chu CL,Hsieh CY,Hsu YJ,Ka SM,Tsai YL,Liu FC,Chen A
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Sat Jul 01 00:00:00 EDT 2017
Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells.
Cancer immunology research
Kubo H,Mensurado S,Gonçalves-Sousa N,Serre K,Silva-Santos B
14-0042 was used in Flow cytometry/Cell sorting to identifies an innate cell network and the molecular determinants responsible for metastasis immunosurveillance, providing support for using the key molecular mediator to improve immunotherapeutic outcomes.
Fri Sep 01 00:00:00 EDT 2017
Pathobiology of the 129:Stat1 -/- mouse model of human age-related ER-positive breast cancer with an immune infiltrate-excluded phenotype.
Breast cancer research : BCR
Mori H,Chen JQ,Cardiff RD,Pénzváltó Z,Hubbard NE,Schuetter L,Hovey RC,Trott JF,Borowsky AD
14-0042 was used in Immunohistochemistry to investigate tumor progression in the 129:Stat1 (-/-) host compared with wild-type 129/SvEv, and describe the immune cell reaction to the tumors.
Sat Sep 02 00:00:00 EDT 2017
Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology.
PLoS pathogens
Pyle CJ,Uwadiae FI,Swieboda DP,Harker JA
14-0042-82 was used in Flow Cytometry to show that during respiratory virus infection the prototypic inflammatory cytokine IL-6 is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27.
Fri Sep 01 00:00:00 EDT 2017
Host-Derived CD70 Suppresses Murine Graft-versus-Host Disease by Limiting Donor T Cell Expansion and Effector Function.
Journal of immunology (Baltimore, Md. : 1950)
Leigh ND,O'Neill RE,Du W,Chen C,Qiu J,Ashwell JD,McCarthy PL,Chen GL,Cao X
14-0042 was used in Flow cytometry/Cell sorting to demonstrate that host CD70 serves as a unique negative regulator of allogeneic T cell response by contributing to donor T cell apoptosis and inhibiting expansion of donor effector T cells.
Sat Jul 01 00:00:00 EDT 2017
miR-451 limits CD4+ T cell proliferative responses to infection in mice.
Immunologic research
Chapman LM,Ture SK,Field DJ,Morrell CN
14-0042 was used in Flow cytometry/Cell sorting to demonstrate that miR-451 is a regulator of host immune responses to Plasmodium infection, particularly in the control of CD4+ T cell proliferation via a Myc-dependent pathway.
Tue Aug 01 00:00:00 EDT 2017
IL-2/Anti-IL-2 Complex Attenuates Inflammation and BBB Disruption in Mice Subjected to Traumatic Brain Injury.
Frontiers in neurology
Gao W,Li F,Zhou Z,Xu X,Wu Y,Zhou S,Yin D,Sun D,Xiong J,Jiang R,Zhang J
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2020
Discrimination of the heterogeneity of bone marrow‑derived dendritic cells.
Molecular medicine reports
Wang J,Dai X,Hsu C,Ming C,He Y,Zhang J,Wei L,Zhou P,Wang CY,Yang J,Gong N
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Wed Nov 01 00:00:00 EDT 2017
PD-1 Blockade Prevents the Development and Progression of Carcinogen-Induced Oral Premalignant Lesions.
Cancer prevention research (Philadelphia, Pa.)
Wang J,Xie T,Wang B,William WN,Heymach JV,El-Naggar AK,Myers JN,Caulin C
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Immunohistochemistry
Fri Dec 01 00:00:00 EST 2017
Immunological effects of vaccines combined with granulocyte colony-stimulating factor on a murine WEHI-3 leukemia model.
Oncology letters
Chen J,Zhang M,Zhou F,Wang J,Niu B,Zhang W
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2017
Effect of follicular helper T cells on the pathogenesis of asthma.
Experimental and therapeutic medicine
Ma X,Sun Z,Zhai P,Yu W,Wang T,Li F,Ding J
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2017
Batf3-dependent CD8α+ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages.
EBioMedicine
Li Y,Liu X,Duan W,Tian H,Zhu G,He H,Yao S,Yi S,Song W,Tang H
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2017
Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting.
Scientific reports
Atkin-Smith GK,Paone S,Zanker DJ,Duan M,Phan TK,Chen W,Hulett MD,Poon IK
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Fri Jan 06 00:00:00 EST 2017
Blocking CTLA-4 while priming with a whole cell vaccine reshapes the oligoclonal T cell infiltrate and eradicates tumors in an orthotopic glioma model.
Oncoimmunology
Field CS,Hunn MK,Ferguson PM,Ruedl C,Ancelet LR,Hermans IF
14-0042 was used in Flow cytometry/Cell sorting to study the effect of the checkpoint blockade on the efficacy of responses induced with a whole tumour-cell vaccine.
Tue Jan 12 00:00:00 EST 2021
IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion.
JCI insight
Le Saout C,Luckey MA,Villarino AV,Smith M,Hasley RB,Myers TG,Imamichi H,Park JH,O'Shea JJ,Lane HC,Catalfamo M
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Thu Nov 16 00:00:00 EST 2017
HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival.
Cell death & disease
Lacher SM,Bruttger J,Kalt B,Berthelet J,Rajalingam K,Wörtge S,Waisman A
14-0042 was used in Flow cytometry/Cell sorting to show that protein prenylation rather than cholesterol biosynthesis pathway is indispensible for T-cell survival.
Thu May 25 00:00:00 EDT 2017
Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.
Nature communications
Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Tue Oct 17 00:00:00 EDT 2017
Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.
Nature communications
Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Tue Oct 17 00:00:00 EDT 2017
Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses.
Nature medicine
Moynihan KD,Opel CF,Szeto GL,Tzeng A,Zhu EF,Engreitz JM,Williams RT,Rakhra K,Zhang MH,Rothschilds AM,Kumari S,Kelly RL,Kwan BH,Abraham W,Hu K,Mehta NK,Kauke MJ,Suh H,Cochran JR,Lauffenburger DA,Wittrup KD,Irvine DJ
14-0042 was used in Flow cytometry/Cell sorting to develop combined immunotherapy against established tumours.
Thu Dec 01 00:00:00 EST 2016
NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer.
Nature
Karki R,Man SM,Malireddi RKS,Kesavardhana S,Zhu Q,Burton AR,Sharma BR,Qi X,Pelletier S,Vogel P,Rosenstiel P,Kanneganti TD
14-0042 was used in Flow cytometry/Cell sorting to explore a key role for NLRC3 in mediating protection against colorectal cancer.
Thu Dec 22 00:00:00 EST 2016
IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.
Cell
Man SM,Karki R,Sasai M,Place DE,Kesavardhana S,Temirov J,Frase S,Zhu Q,Malireddi RKS,Kuriakose T,Peters JL,Neale G,Brown SA,Yamamoto M,Kanneganti TD
14-0042 was used in Flow cytometry/Cell sorting to show that the interferon-inducible protein IRGB10 is essential for activation of the DNA-sensing AIM2 inflammasome by Francisella novicida.
Thu Oct 06 00:00:00 EDT 2016
Acidic chitinase primes the protective immune response to gastrointestinal nematodes.
Nature immunology
Vannella KM,Ramalingam TR,Hart KM,de Queiroz Prado R,Sciurba J,Barron L,Borthwick LA,Smith AD,Mentink-Kane M,White S,Thompson RW,Cheever AW,Bock K,Moore I,Fitz LJ,Urban JF,Wynn TA
14-0042 was used in Flow cytometry/Cell sorting to use AMCase-deficient mice as a means to dissect the role of the enzyme in several models of helminth infection and type 2 cytokine-driven airway inflammation.
Sun May 01 00:00:00 EDT 2016
CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis.
Nature immunology
Cibrian D,Saiz ML,de la Fuente H,Sánchez-Díaz R,Moreno-Gonzalo O,Jorge I,Ferrarini A,Vázquez J,Punzón C,Fresno M,Vicente-Manzanares M,Daudén E,Fernández-Salguero PM,Martín P,Sánchez-Madrid F
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2016
Oligodendrocyte death results in immune-mediated CNS demyelination.
Nature neuroscience
Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2016
Autologous stem cell transplantation aids autoimmune patients by functional renewal and TCR diversification of regulatory T cells.
Blood
Delemarre EM,van den Broek T,Mijnheer G,Meerding J,Wehrens EJ,Olek S,Boes M,van Herwijnen MJ,Broere F,van Royen A,Wulffraat NM,Prakken BJ,Spierings E,van Wijk F
14-0042 was used in Flow cytometry/Cell sorting to suggest Treg therapy may hamper development of long-term tolerance and should be approached with caution in the clinical autologous setting.
Thu Jan 07 00:00:00 EST 2016
Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses.
The Journal of experimental medicine
Ruane D,Chorny A,Lee H,Faith J,Pandey G,Shan M,Simchoni N,Rahman A,Garg A,Weinstein EG,Oropallo M,Gaylord M,Ungaro R,Cunningham-Rundles C,Alexandropoulos K,Mucida D,Merad M,Cerutti A,Mehandru S
14-0042 was used in Flow cytometry/Cell sorting to demonstrate the role of the microbiota in modulating the protective efficacy of intranasal vaccination through their effect on the IgA class-switching function of lung dendritic cells.
Mon Jan 11 00:00:00 EST 2016
STAT3/5-Dependent IL9 Overexpression Contributes to Neoplastic Cell Survival in Mycosis Fungoides.
Clinical cancer research : an official journal of the American Association for Cancer Research
Vieyra-Garcia PA,Wei T,Naym DG,Fredholm S,Fink-Puches R,Cerroni L,Odum N,O'Malley JT,Gniadecki R,Wolf P
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Fri Jul 01 00:00:00 EDT 2016
Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.
Mucosal immunology
Mohapatra A,Van Dyken SJ,Schneider C,Nussbaum JC,Liang HE,Locksley RM
14-0042 was used in Flow cytometry/Cell sorting to study how ILC2s link alveolar function to regulation of airway flow, revealing a key interaction between resident lymphoid and structural cells that might underlie similar organisational hierarchies in other organs.
Fri Jan 01 00:00:00 EST 2016
Increased Bacterial Load and Expression of Antimicrobial Peptides in Skin of Barrier-Deficient Mice with Reduced Cancer Susceptibility.
The Journal of investigative dermatology
Natsuga K,Cipolat S,Watt FM
14-0042 was used in Immunofluorescence to conclude that the atopic characteristics of EPI-/- skin are a consequence of the defective barrier rather than a response to the increased bacterial load.
Fri Jan 01 00:00:00 EST 2016
LV305, a dendritic cell-targeting integration-deficient ZVex(TM)-based lentiviral vector encoding NY-ESO-1, induces potent anti-tumor immune response.
Molecular therapy oncolytics
Albershardt TC,Campbell DJ,Parsons AJ,Slough MM,Ter Meulen J,Berglund P
14-0042 was used in Flow cytometry/Cell sorting to develop an integration-deficient lentiviral vector to deliver the tumour antigen NY-ESO-1 to human dendritic cells in vivo.
Wed Sep 14 00:00:00 EDT 2016
Differential T Cell Cytokine Receptivity and Not Signal Quality Distinguishes IL-6 and IL-10 Signaling during Th17 Differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Jones LL,Alli R,Li B,Geiger TL
14-0042 was used in Flow cytometry/Cell sorting to demonstrate a key role for the regulation of receptor expression in differentiating the functional outcomes of IL-6 and IL-10 signalling.
Fri Apr 01 00:00:00 EDT 2016
Regulatory T Cells Control Th2-Dominant Murine Autoimmune Gastritis.
Journal of immunology (Baltimore, Md. : 1950)
Harakal J,Rival C,Qiao H,Tung KS
14-0042-82 was used in Flow Cytometry to suggest that Tregs maintain physiological tolerance to clinically relevant gastric autoantigens, and Th2 responses can be a pathogenic mechanism in AIG.
Fri Jul 01 00:00:00 EDT 2016
Chronic Gastrointestinal Nematode Infection Mutes Immune Responses to Mycobacterial Infection Distal to the Gut.
Journal of immunology (Baltimore, Md. : 1950)
Obieglo K,Feng X,Bollampalli VP,Dellacasa-Lindberg I,Classon C,Österblad M,Helmby H,Hewitson JP,Maizels RM,Gigliotti Rothfuchs A,Nylén S
14-0042 was used in Flow cytometry/Cell sorting to show that an intestinal nematode can mute T cell responses to mycobacterial and reduce control of secondary infections outside the gut.
Tue Mar 01 00:00:00 EST 2016
Genomic and immunologic factors associated with viral pathogenesis in a lethal EV71 infected neonatal mouse model.
Molecular medicine reports
Yue Y,Li P,Song N,Li B,Li Z,Guo Y,Zhang W,Wei MQ,Gai Z,Meng H,Wang J,Qin L
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Sun May 01 00:00:00 EDT 2016
Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells.
Nature communications
Baptista MA,Keszei M,Oliveira M,Sunahara KK,Andersson J,Dahlberg CI,Worth AJ,Liedén A,Kuo IC,Wallin RP,Snapper SB,Eidsmo L,Scheynius A,Karlsson MC,Bouma G,Burns SO,Forsell MN,Thrasher AJ,Nylén S,Westerberg LS
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Mon Jul 18 00:00:00 EDT 2016
A Novel Model of Asymptomatic Plasmodium Parasitemia That Recapitulates Elements of the Human Immune Response to Chronic Infection.
PloS one
Fontana MF,Baccarella A,Craft JF,Boyle MJ,McIntyre TI,Wood MD,Thorn KS,Anidi C,Bayat A,Chung MR,Hamburger R,Kim CY,Pearman E,Pham J,Tang JJ,Boon L,Kamya MR,Dorsey G,Feeney ME,Kim CC
14-0042 was used in Flow cytometry/Cell sorting to investigate aspects of the human immune response to asymptomatic persistent Plasmodium infection using a novel animal model.
Wed Aug 02 00:00:00 EDT 2017
Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells.
eLife
Allison KA,Sajti E,Collier JG,Gosselin D,Troutman TD,Stone EL,Hedrick SM,Glass CK
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Mon Jul 04 00:00:00 EDT 2016
CRISPR-Mediated Triple Knockout of SLAMF1, SLAMF5 and SLAMF6 Supports Positive Signaling Roles in NKT Cell Development.
PloS one
Huang B,Gomez-Rodriguez J,Preite S,Garrett LJ,Harper UL,Schwartzberg PL
14-0042 was used in Flow cytometry/Cell sorting to elucidate the contribution of the SLAM receptors in immunodysregulation observed in X-linked lymphoproliferative syndrome Type 1.
Mon Jul 24 00:00:00 EDT 2017
Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor.
Scientific reports
Brandstätter O,Schanz O,Vorac J,König J,Mori T,Maruyama T,Korkowski M,Haarmann-Stemmann T,von Smolinski D,Schultze JL,Abel J,Esser C,Takeyama H,Weighardt H,Förster I
14-0042 was used in Flow cytometry/Cell sorting to highlight the physiologic importance of cell-type specific balancing of AhR/AhRR expression in response to microbial, nutritional and other environmental stimuli.
Tue May 17 00:00:00 EDT 2016
Immune signatures of protective spleen memory CD8 T cells.
Scientific reports
Brinza L,Djebali S,Tomkowiak M,Mafille J,Loiseau C,Jouve PE,de Bernard S,Buffat L,Lina B,Ottmann M,Rosa-Calatrava M,Schicklin S,Bonnefoy N,Lauvau G,Grau M,Wencker M,Arpin C,Walzer T,Leverrier Y,Marvel J
14-0042 was used in Flow cytometry/Cell sorting to identify a range of qualities uniquely associated with protective memory cells.
Thu Nov 24 00:00:00 EST 2016
Epidermal Notch1 recruits RORγ(+) group 3 innate lymphoid cells to orchestrate normal skin repair.
Nature communications
Li Z,Hodgkinson T,Gothard EJ,Boroumand S,Lamb R,Cummins I,Narang P,Sawtell A,Coles J,Leonov G,Reboldi A,Buckley CD,Cupedo T,Siebel C,Bayat A,Coles MC,Ambler CA
14-0042 was used in Immunohistochemistry to invesitgate whether Notch directs non-cell-autonomous signalling in adult tissues, showing that it recruits RORγ(+) group 3 innate lymphoid cells to orchestrate normal skin repair.
Thu Apr 21 00:00:00 EDT 2016
CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation.
Nature communications
Cao W,Guo J,Wen X,Miao L,Lin F,Xu G,Ma R,Yin S,Hui Z,Chen T,Guo S,Chen W,Huang Y,Liu Y,Wang J,Wei L,Wang L
14-0042 was used in Flow cytometry/Cell sorting to investigate whether the CpG-binding protein Cxxc1 plays a role in thymocyte development.
Mon May 23 00:00:00 EDT 2016
Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems.
The Journal of biological chemistry
Wang B,Merillat SA,Vincent M,Huber AK,Basrur V,Mangelberger D,Zeng L,Elenitoba-Johnson K,Miller RA,Irani DN,Dlugosz AA,Schnell S,Scaglione KM,Paulson HL
14-0042 was used in Flow cytometry/Cell sorting to establish that UBE2W is an important protein for early postnatal survival and the normal functioning of multiple organ systems.
Fri Feb 05 00:00:00 EST 2016
Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator.
Nature communications
Zhu ML,Bakhru P,Conley B,Nelson JS,Free M,Martin A,Starmer J,Wilson EM,Su MA
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Wed Apr 13 00:00:00 EDT 2016
Irradiation of necrotic cancer cells, employed for pulsing dendritic cells (DCs), potentiates DC vaccine-induced antitumor immunity against high-grade glioma.
Oncoimmunology
Vandenberk L,Garg AD,Verschuere T,Koks C,Belmans J,Beullens M,Agostinis P,De Vleeschouwer S,Van Gool SW
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2016
Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination.
Scientific reports
Stifter K,Schuster C,Schlosser M,Boehm BO,Schirmbeck R
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Mon Jul 11 00:00:00 EDT 2016
Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions.
The Journal of biological chemistry
Li X,Acuff NV,Peeks AR,Kirkland R,Wyatt KD,Nagy T,Watford WT
14-0042-82 was used in Flow Cytometry to demonstrate that the serine/threonine kinase tumour progression locus 2 constrains the development of inducible regulatory T cells.
Fri Aug 05 00:00:00 EDT 2016
Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting.
Nature biotechnology
Chen HJ,Sun J,Huang Z,Hou H,Arcilla M,Rakhilin N,Joe DJ,Choi J,Gadamsetty P,Milsom J,Nandakumar G,Longman R,Zhou XK,Edwards R,Chen J,Chen KY,Bu P,Wang L,Xu Y,Munroe R,Abratte C,Miller AD,Gümüş ZH,Shuler M,Nishimura N,Edelmann W,Shen X,Lipkin SM
14-0042 was used in Flow cytometry/Cell sorting to create chemokine-targeted mouse models that recapitulate the majority of common human somatic CRC mutations.
Mon Jun 01 00:00:00 EDT 2015
Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System.
Immunity
Guerrini MM,Okamoto K,Komatsu N,Sawa S,Danks L,Penninger JM,Nakashima T,Takayanagi H
14-0042-82 was used in Flow Cytometry to show that receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL) on T cells regulates C-C type chemokine ligand 20 (CCL20) production by astrocytes and T cell localization in the CNS.
Tue Dec 15 00:00:00 EST 2015
The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture.
Nature immunology
Astarita JL,Cremasco V,Fu J,Darnell MC,Peck JR,Nieves-Bonilla JM,Song K,Kondo Y,Woodruff MC,Gogineni A,Onder L,Ludewig B,Weimer RM,Carroll MC,Mooney DJ,Xia L,Turley SJ
14-0042 was used in Flow cytometry/Cell sorting to demonstrate that podoplanin regulates lymph node microarchitecture and fibroblastic reticular cell actomyosin contractility.
Thu Jan 01 00:00:00 EST 2015
LEF-1 and TCF-1 orchestrate T(FH) differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6.
Nature immunology
Choi YS,Gullicksrud JA,Xing S,Zeng Z,Shan Q,Li F,Love PE,Peng W,Xue HH,Crotty S
14-0042 was used in Flow cytometry/Cell sorting to report that selective loss of Lef1 or Tcf7 results in T(FH) cell defects.
Tue Sep 01 00:00:00 EDT 2015
Neutrophil-related factors as biomarkers in EAE and MS.
The Journal of experimental medicine
Rumble JM,Huber AK,Krishnamoorthy G,Srinivasan A,Giles DA,Zhang X,Wang L,Segal BM
14-0042 was used in Flow cytometry/Cell sorting to provide evidence of neutrophil involvement in MS and the animal model EAE, and suggest neutrophil-related molecules as an alternative source of novel biomarkers and therapeutic targets in MS.
Mon Jan 12 00:00:00 EST 2015
Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice.
Cardiovascular research
Wan W,Liu Q,Lionakis MS,Marino AP,Anderson SA,Swamydas M,Murphy PM
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Mon Jun 01 00:00:00 EDT 2015
LKB1 inhibition of NF-κB in B cells prevents T follicular helper cell differentiation and germinal center formation.
EMBO reports
Walsh NC,Waters LR,Fowler JA,Lin M,Cunningham CR,Brooks DG,Rehg JE,Morse HC,Teitell MA
14-0042 was used in Flow cytometry/Cell sorting to show that LKB1 expression in B cells maintains B-cell quiescence and prevents the premature formation of germinal centers.
Mon Jun 01 00:00:00 EDT 2015
Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells.
Frontiers in immunology
Vogel AJ,Brown DM
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Fri Jul 10 00:00:00 EDT 2015
BCG Skin Infection Triggers IL-1R-MyD88-Dependent Migration of EpCAMlow CD11bhigh Skin Dendritic cells to Draining Lymph Node During CD4+ T-Cell Priming.
PLoS pathogens
Bollampalli VP,Harumi Yamashiro L,Feng X,Bierschenk D,Gao Y,Blom H,Henriques-Normark B,Nylén S,Rothfuchs AG
14-0042 was used in Flow cytometry/Cell sorting to investigate the transport of antigens from the periphery to the draining lymph node during infection with Mycobacterium bovis Bacille Calmette-Guérin.
Thu Oct 01 00:00:00 EDT 2015
Enhancement of the proapoptotic properties of newcastle disease virus promotes tumor remission in syngeneic murine cancer models.
Molecular cancer therapeutics
Cuadrado-Castano S,Ayllon J,Mansour M,de la Iglesia-Vicente J,Jordan S,Tripathi S,García-Sastre A,Villar E
14-0042 was used in Flow cytometry/Cell sorting to demonstrate an augmented agent for cancer therapy which exploits the oncolytic properties of Newcastle disease virus.
Fri May 01 00:00:00 EDT 2015
Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3⁺ and Foxp3⁻ T cells.
Immunology and cell biology
Franckaert D,Dooley J,Roos E,Floess S,Huehn J,Luche H,Fehling HJ,Liston A,Linterman MA,Schlenner SM
14-0042 was used in Flow cytometry/Cell sorting to investigate the functional requirement for CD28 during peripheral regulatory T cell post thymic selection.
Wed Apr 01 00:00:00 EDT 2015
Dendritic Cell-Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma.
Journal of immunology (Baltimore, Md. : 1950)
Dey M,Chang AL,Miska J,Wainwright DA,Ahmed AU,Balyasnikova IV,Pytel P,Han Y,Tobias A,Zhang L,Qiao J,Lesniak MS
14-0042 was used in Flow cytometry/Cell sorting to compare the ability of myeloid and plasmacytoid dendritic cells to generate effective antiglioma immunity.
Wed Jul 01 00:00:00 EDT 2015
Cutting edge: NF-κB p65 and c-Rel control epidermal development and immune homeostasis in the skin.
Journal of immunology (Baltimore, Md. : 1950)
Grinberg-Bleyer Y,Dainichi T,Oh H,Heise N,Klein U,Schmid RM,Hayden MS,Ghosh S
14-0042-82 was used in Flow Cytometry to analyse the function of canonical NF-κB in the epidermis using CRE-mediated deletion of p65 and c-Rel in keratinocytes.
Sun Mar 15 00:00:00 EDT 2015
Murine Fibroblastic Reticular Cells From Lymph Node Interact With CD4+ T Cells Through CD40-CD40L.
Transplantation
Nakayama Y,Brinkman CC,Bromberg JS
14-0042 was used in Flow cytometry/Cell sorting to elucidate the mechanisms facilitating bidirectional communication between fibroblastic reticular cells and CD4(+) T cells.
Sat Aug 01 00:00:00 EDT 2015
A tumor lysate is an effective vaccine antigen for the stimulation of CD4(+) T-cell function and subsequent induction of antitumor immunity mediated by CD8(+) T cells.
Cancer biology & therapy
Kawahara M,Takaku H
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Mon Sep 12 00:00:00 EDT 2016
Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine.
Human vaccines & immunotherapeutics
Teng X,Tian M,Li J,Tan S,Yuan X,Yu Q,Jing Y,Zhang Z,Yue T,Zhou L,Fan X
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Fri Mar 11 00:00:00 EST 2016
Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules.
Gene therapy
Rodriguez-Peña AB,Gomez-Rodriguez J,Kortum RL,Palmer DC,Yu Z,Guittard GC,Wohlfert EA,Silver PB,Misplon JA,Sommers CL,Feigenbaum L,Epstein SL,Caspi RR,Belkaid Y,Restifo NP,Samelson LE,Balagopalan L
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2015
dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.
Nature communications
Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Tue Sep 15 00:00:00 EDT 2015
dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.
Nature communications
Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Tue Sep 15 00:00:00 EDT 2015
Recombinant adeno-vaccine expressing enterovirus 71-like particles against hand, foot, and mouth disease.
PLoS neglected tropical diseases
Tsou YL,Lin YW,Shao HY,Yu SL,Wu SR,Lin HY,Liu CC,Huang C,Chong P,Chow YH
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2015
Bortezomib Plus Continuous B Cell Depletion Results in Sustained Plasma Cell Depletion and Amelioration of Lupus Nephritis in NZB/W F1 Mice.
PloS one
Khodadadi L,Cheng Q,Alexander T,Sercan-Alp Ö,Klotsche J,Radbruch A,Hiepe F,Hoyer BF,Taddeo A
14-0042 was used in Flow cytometry/Cell sorting to suggest that the effective depletion of LLPCs using bortezomib in combination with a therapy that continuously targeting B cells as their precursors may prevent the regeneration of autoreactive LLPCs.
Mon May 23 00:00:00 EDT 2016
All-trans retinoid acid promotes allogeneic corneal graft survival in mice by regulating Treg-Th17 balance in the presence of TGF-β.
BMC immunology
Wang X,Wang W,Xu J,Wu S,Le Q
14-0042 was used in Flow cytometry/Cell sorting to investigate the potential effect of the application of ATRA and TGF-β on immunological tolerance and the treatment of posttransplant rejection.
Thu Mar 19 00:00:00 EDT 2015
Interleukin-35 administration counteracts established murine type 1 diabetes--possible involvement of regulatory T cells.
Scientific reports
Singh K,Kadesjö E,Lindroos J,Hjort M,Lundberg M,Espes D,Carlsson PO,Sandler S,Thorvaldson L
14-0042 was used in Flow cytometry/Cell sorting to suggest that insufficient IL-35 levels play a pivotal role in the development of T1D and that treatment with IL-35 should be investigated in treatment of T1D and other autoimmune diseases.
Thu Jul 30 00:00:00 EDT 2015
Near-infrared photoactivatable control of Ca(2+) signaling and optogenetic immunomodulation.
eLife
He L,Zhang Y,Ma G,Tan P,Li Z,Zang S,Wu X,Jing J,Fang S,Zhou L,Wang Y,Huang Y,Hogan PG,Han G,Zhou Y
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Tue Dec 08 00:00:00 EST 2015
DNA Repair Cofactors ATMIN and NBS1 Are Required to Suppress T Cell Activation.
PLoS genetics
Prochazkova J,Sakaguchi S,Owusu M,Mazouzi A,Wiedner M,Velimezi G,Moder M,Turchinovich G,Hladik A,Gurnhofer E,Hayday A,Behrens A,Knapp S,Kenner L,Ellmeier W,Loizou JI
14-0042 was used in Flow cytometry/Cell sorting to investigate the roles of ATMIN and NBS1, either alone or in combination, in T cells.
Sun Nov 01 00:00:00 EDT 2015
In Situ Peptide-MHC-II Tetramer Staining of Antigen-Specific CD4+ T Cells in Tissues.
PloS one
Dileepan T,Kim HO,Cleary PP,Skinner PJ
14-0042 was used in Immunohistochemistry to show 2W:I-Ab tetramer-binding CD4+ T cells in GAS-2W- but not GAS-infected mice.
Thu Apr 21 00:00:00 EDT 2016
Aquaporin-9-expressing neutrophils are required for the establishment of contact hypersensitivity.
Scientific reports
Moniaga CS,Watanabe S,Honda T,Nielsen S,Hara-Chikuma M
14-0042 was used in Flow cytometry/Cell sorting to suggest that AQP9 is required for the development of sensitisation during cutaneous acquired immune responses via regulating neutrophil function.
Thu Oct 22 00:00:00 EDT 2015
Latent virus infection upregulates CD40 expression facilitating enhanced autoimmunity in a model of multiple sclerosis.
Scientific reports
Casiraghi C,Márquez AC,Shanina I,Horwitz MS
14-0042 was used in Flow cytometry/Cell sorting to investigate the cause of enhanced experimental autoimmune encephalomyelitis following infection with murine γ-herpesvirus 68.
Thu Sep 10 00:00:00 EDT 2015
The oncoprotein and transcriptional regulator Bcl-3 governs plasticity and pathogenicity of autoimmune T cells.
Immunity
Tang W,Wang H,Claudio E,Tassi I,Ha HL,Saret S,Siebenlist U
14-0042 was used in Flow cytometry/Cell sorting to investigate a T-cell-intrinsic function of the transcriptional regulator Bcl-3 in autoimmunity.
Thu Oct 16 00:00:00 EDT 2014
The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells.
Nature immunology
Xiao N,Eto D,Elly C,Peng G,Crotty S,Liu YC
14-0042 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms that regulate the induction of T(FH) cells, showing that Itch is required.
Tue Jul 01 00:00:00 EDT 2014
Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages.
Proceedings of the National Academy of Sciences of the United States of America
Rei M,Gonçalves-Sousa N,Lança T,Thompson RG,Mensurado S,Balkwill FR,Kulbe H,Pennington DJ,Silva-Santos B
14-0042 was used in Flow cytometry/Cell sorting to characterise the role of tumour-associated γδ T cells on disease development using a model peritoneal/ovarian cancer cell line.
Tue Aug 26 00:00:00 EDT 2014
IL4 limits the efficacy of tumor-targeted antibody therapy in a murine model.
Cancer immunology research
Surana R,Wang S,Xu W,Jablonski SA,Weiner LM
14-0042 was used in Flow cytometry/Cell sorting to demonstrate that IL4 neutralisation enhances the efficacy of trastuzumab by influencing the phenotype of myeloid cells within the tumour microenvironment.
Sat Nov 01 00:00:00 EDT 2014
Modulation of distinct asthmatic phenotypes in mice by dose-dependent inhalation of microbial products.
Environmental health perspectives
Whitehead GS,Thomas SY,Cook DN
14-0042 was used in Flow cytometry/Cell sorting to assess pulmonary cytokine production and airway inflammation following challenge with ovalbumin and LPS.
Wed Jan 01 00:00:00 EST 2014
Gene targeting in NOD mouse embryos using zinc-finger nucleases.
Diabetes
Chen YG,Forsberg MH,Khaja S,Ciecko AE,Hessner MJ,Geurts AM
14-0042 was used in Flow cytometry/Cell sorting to investigate how to generate gene-targeted knockouts in a pure NOD background by using ZFNs without potential confounding factors introduced by contaminating genetic materials obtained from other strains.
Wed Jan 01 00:00:00 EST 2014
Central memory CD4+ T cells are responsible for the recombinant Bacillus Calmette-Guérin ΔureC::hly vaccine's superior protection against tuberculosis.
The Journal of infectious diseases
Vogelzang A,Perdomo C,Zedler U,Kuhlmann S,Hurwitz R,Gengenbacher M,Kaufmann SH
14-0042 was used in Flow cytometry/Cell sorting to investigate the T-cell population required for recombinant Bacillus Calmette-Guérin δureC::hly vaccine's enhanced protection against tuberculosis.
Mon Dec 15 00:00:00 EST 2014
IL-18, but not IL-12, induces production of IFN-γ in the immunosuppressive environment of HPV16 E7 transgenic hyperplastic skin.
The Journal of investigative dermatology
Gosmann C,Frazer IH,Mattarollo SR,Blumenthal A
14-0042 was used in Flow cytometry/Cell sorting to show that IL-18 contributes to inducing IFN-γ in an immunosuppressive cutaneous environment caused by viral oncogene-driven hyperplasia.
Wed Oct 01 00:00:00 EDT 2014
TLR2 engagement on CD4(+) T cells enhances effector functions and protective responses to Mycobacterium tuberculosis.
European journal of immunology
Reba SM,Li Q,Onwuzulike S,Ding X,Karim AF,Hernandez Y,Fulton SA,Harding CV,Lancioni CL,Nagy N,Rodriguez ME,Wearsch PA,Rojas RE
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Thu May 01 00:00:00 EDT 2014
γδ T cells restrain extrathymic development of Foxp3+-inducible regulatory T cells via IFN-γ.
European journal of immunology
Visperas A,Shen B,Min B
14-0042 was used in Flow cytometry/Cell sorting to reveal a novel function of γδ T cells in limiting the generation of iTreg cells, potentially balancing immunity and tolerance.
Fri Aug 01 00:00:00 EDT 2014
Colitogenic effector T cells: roles of gut-homing integrin, gut antigen specificity and γδ T cells.
Immunology and cell biology
Do JS,Visperas A,Freeman ML,Iwakura Y,Oukka M,Min B
14-0042 was used in Flow cytometry/Cell sorting to demonstrate that T-cell colitogenicity is achieved through multiple processes, offering a therapeutic rationale by intervening these pathways.
Wed Jan 01 00:00:00 EST 2014
In vivo functional mapping of the conserved protein domains within murine Themis1.
Immunology and cell biology
Zvezdova E,Lee J,El-Khoury D,Barr V,Akpan I,Samelson L,Love PE
14-0042 was used in Flow cytometry/Cell sorting to investigate the functional importance of different Themis1 domains.
Mon Sep 01 00:00:00 EDT 2014
The DC-HIL/syndecan-4 pathway regulates autoimmune responses through myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Chung JS,Tamura K,Akiyoshi H,Cruz PD,Ariizumi K
14-0042 was used in Flow cytometry/Cell sorting to investigate the mechanisms of regulation of autoimmune responses in experimental autoimmune encephalomyelitis.
Sat Mar 15 00:00:00 EDT 2014
TLR4 activation enhances the PD-L1-mediated tolerogenic capacity of colonic CD90+ stromal cells.
Journal of immunology (Baltimore, Md. : 1950)
Beswick EJ,Johnson JR,Saada JI,Humen M,House J,Dann S,Qiu S,Brasier AR,Powell DW,Reyes VE,Pinchuk IV
14-0042 was used in Flow cytometry/Cell sorting to investigate whether signalling through TLRs contribute to the regulation PD-1 ligands on CD90(+) myofibroblasts/fibroblasts upon colonic mucosal tolerance.
Mon Sep 01 00:00:00 EDT 2014
Cutting edge: CD8+ recent thymic emigrants exhibit increased responses to low-affinity ligands and improved access to peripheral sites of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Berkley AM,Fink PJ
14-0042-82 was used in Flow Cytometry to investigate if the maturation state of peripheral T cells impacts the response to bacterial infection due to intrinsic differences in TCR signaling.
Wed Oct 01 00:00:00 EDT 2014
B cell-specific loss of Lyn kinase leads to autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Lamagna C,Hu Y,DeFranco AL,Lowell CA
14-0042-82 was used in Flow Cytometry to demonstrate that B cell-intrinsic Lyn-dependent signalling pathways regulate B cell homeostasis and activation.
Sat Feb 01 00:00:00 EST 2014
B cells in T follicular helper cell development and function: separable roles in delivery of ICOS ligand and antigen.
Journal of immunology (Baltimore, Md. : 1950)
Weinstein JS,Bertino SA,Hernandez SG,Poholek AC,Teplitzky TB,Nowyhed HN,Craft J
14-0042 was used in Flow cytometry/Cell sorting to study the role of B cells in the development of Tfh cells and germinal centres.
Tue Apr 01 00:00:00 EDT 2014
IL-21 receptor signalling partially mediates Th2-mediated allergic airway responses.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Lajoie S,Lewkowich I,Herman NS,Sproles A,Pesce JT,Wynn TA,Grusby MJ,Hamid Q,Wills-Karp M
14-0042 was used in Flow cytometry/Cell sorting to suggest that IL-21 plays an important role in the allergic diathesis by enhancing Th2 cytokine production through multiple mechanisms.
Tue Jul 01 00:00:00 EDT 2014
CXCR4 is dispensable for T cell egress from chronically inflamed skin via the afferent lymph.
PloS one
Geherin SA,Wilson RP,Jennrich S,Debes GF
14-0042 was used in Flow cytometry/Cell sorting to assess the role of CXCR4 for T cell egress from chronically inflamed skin.
Wed Jan 14 00:00:00 EST 2015
A flagellin-derived toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity.
PloS one
Leigh ND,Bian G,Ding X,Liu H,Aygun-Sunar S,Burdelya LG,Gudkov AV,Cao X
14-0042 was used in Flow cytometry/Cell sorting to assess the immunogenic capabilities of CBLB502, a toll-like receptor 5 agonist.
Wed Sep 17 00:00:00 EDT 2014
Potential role of IL-17-producing iNKT cells in type 1 diabetes.
PloS one
Li S,Joseph C,Becourt C,Klibi J,Luce S,Dubois-Laforgue D,Larger E,Boitard C,Benlagha K
14-0042 was used in Flow cytometry/Cell sorting to investigate the status and potential role of iNKT17 in type 1 diabetes.
Thu Jan 22 00:00:00 EST 2015
Interferon-γ induces expression of MHC class II on intestinal epithelial cells and protects mice from colitis.
PloS one
Thelemann C,Eren RO,Coutaz M,Brasseit J,Bouzourene H,Rosa M,Duval A,Lavanchy C,Mack V,Mueller C,Reith W,Acha-Orbea H
14-0042 was used in Flow cytometry/Cell sorting to investigate how epithelial MHCII expression is induced and how a deficiency in inducible epithelial MHCII expression alters susceptibility to colitis and the outcome of colon-specific immune responses.
Mon Dec 22 00:00:00 EST 2014
Leukocyte population dynamics and detection of IL-9 as a major cytokine at the mouse fetal-maternal interface.
PloS one
Habbeddine M,Verbeke P,Karaz S,Bobé P,Kanellopoulos-Langevin C
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Wed Jun 10 00:00:00 EDT 2015
The efficacy of tumor debulking surgery is improved by adjuvant immunotherapy using imiquimod and anti-CD40.
BMC cancer
Khong A,Cleaver AL,Fahmi Alatas M,Wylie BC,Connor T,Fisher SA,Broomfield S,Lesterhuis WJ,Currie AJ,Lake RA,Robinson BW
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Wed Dec 17 00:00:00 EST 2014
P2X7 receptor modulates inflammatory and functional pulmonary changes induced by silica.
PloS one
Monção-Ribeiro LC,Faffe DS,Santana PT,Vieira FS,da Graça CL,Marques-da-Silva C,Machado MN,Caruso-Neves C,Zin WA,Borojevic R,Takiya CM,Coutinho-Silva R
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Thu Sep 17 00:00:00 EDT 2015
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
Nature
Kleinewietfeld M,Manzel A,Titze J,Kvakan H,Yosef N,Linker RA,Muller DN,Hafler DA
14-0042 was used in Flow cytometry/Cell sorting to investigate the environmental factors that influence TH17 cells, showing that sodium chloride induces TH17 cells and drives autoimmune disease.
Thu Apr 25 00:00:00 EDT 2013
Hematopoietic progenitor cell lines with myeloid and lymphoid potential.
Nature methods
Redecke V,Wu R,Zhou J,Finkelstein D,Chaturvedi V,High AA,Häcker H
14-0042 was used in Flow cytometry/Cell sorting to develop methods to investigate immune-cell differentiation and function, showing that immortalised hematopoietic progenitor cell lines can be produced, with myeloid and lymphoid potential.
Thu Aug 01 00:00:00 EDT 2013
The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus.
Nature immunology
Keating R,Hertz T,Wehenkel M,Harris TL,Edwards BA,McClaren JL,Brown SA,Surman S,Wilson ZS,Bradley P,Hurwitz J,Chi H,Doherty PC,Thomas PG,McGargill MA
14-0042 was used in Flow cytometry/Cell sorting to investigate the immunological mechanisms that promote heterosubtypic immunity, showing that mTOR modulates the antibody response to provide cross-protective immunity to lethal infection.
Sun Dec 01 00:00:00 EST 2013
Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity.
Nature immunology
Kidani Y,Elsaesser H,Hock MB,Vergnes L,Williams KJ,Argus JP,Marbois BN,Komisopoulou E,Wilson EB,Osborne TF,Graeber TG,Reue K,Brooks DG,Bensinger SJ
14-0042 was used in Flow cytometry/Cell sorting to provide insights into the molecular signals that underlie the metabolic reprogramming of CD8(+) T cells during the transition from quiescence to activation.
Wed May 01 00:00:00 EDT 2013
Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation.
Nature immunology
Garris CS,Wu L,Acharya S,Arac A,Blaho VA,Huang Y,Moon BS,Axtell RC,Ho PP,Steinberg GK,Lewis DB,Sobel RA,Han DK,Steinman L,Snyder MP,Hla T,Han MH
14-0042 was used in Flow cytometry/Cell sorting to identify the non-functioning S1P1 gene as a key factor contributing to the development of severe experimental autoimmune encephalomyelitis.
Fri Nov 01 00:00:00 EDT 2013
Nrf2 regulates haematopoietic stem cell function.
Nature cell biology
Tsai JJ,Dudakov JA,Takahashi K,Shieh JH,Velardi E,Holland AM,Singer NV,West ML,Smith OM,Young LF,Shono Y,Ghosh A,Hanash AM,Tran HT,Moore MA,van den Brink MR
14-0042 was used in Flow cytometry/Cell sorting to investigate the link between Nrf2 and CXCR4, thought to partially contribute to the maintenance of haematopoietic stem cell function.
Fri Mar 01 00:00:00 EST 2013
Inflammatory neovascularization during graft-versus-host disease is regulated by αv integrin and miR-100.
Blood
Leonhardt F,Grundmann S,Behe M,Bluhm F,Dumont RA,Braun F,Fani M,Riesner K,Prinz G,Hechinger AK,Gerlach UV,Dierbach H,Penack O,Schmitt-Gräff A,Finke J,Weber WA,Zeiser R
14-0042-82 was used in Flow Cytometry to identify negative regulation of GvHD-related neovascularization by miR-100.
Thu Apr 25 00:00:00 EDT 2013
Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice.
Blood
Nijagal A,Derderian C,Le T,Jarvis E,Nguyen L,Tang Q,Mackenzie TC
14-0042 was used in Flow cytometry/Cell sorting to investigate the mechanisms of antigen presentation that induce a tolerant post-transplant immune response.
Thu May 30 00:00:00 EDT 2013
Activation of inflammasome signaling mediates pathology of acute P. aeruginosa pneumonia.
The Journal of clinical investigation
Cohen TS,Prince AS
14-0042 was used in Flow cytometry/Cell sorting to demonstrate that the inflammasome provides a potential target to limit the pathological consequences of acute P. aeruginosa pulmonary infection.
Mon Apr 01 00:00:00 EDT 2013
MIP-1α/CCL3-mediated maintenance of leukemia-initiating cells in the initiation process of chronic myeloid leukemia.
The Journal of experimental medicine
Baba T,Naka K,Morishita S,Komatsu N,Hirao A,Mukaida N
14-0042 was used in Flow cytometry/Cell sorting to investigate the interaction between leukaemia-initiating cells and normal hematopoietic cells at the early phase of chronic myeloid leukaemia, showing MIP-1α/CCL3-mediated maintenance of initiating cells.
Mon Nov 18 00:00:00 EST 2013
B7-H4Ig inhibits mouse and human T-cell function and treats EAE via IL-10/Treg-dependent mechanisms.
Journal of autoimmunity
Podojil JR,Liu LN,Marshall SA,Chiang MY,Goings GE,Chen L,Langermann S,Miller SD
14-0042 was used in Flow cytometry/Cell sorting to investigate the inhibition of mouse and human T-cell function and treatment of EAE via IL-10/Treg-dependent mechanisms through B7-H4Ig.
Thu Aug 01 00:00:00 EDT 2013
Aire deficiency promotes TRP-1-specific immune rejection of melanoma.
Cancer research
Zhu ML,Nagavalli A,Su MA
14-0042 was used in Flow cytometry/Cell sorting to show how Aire deficiency can enhance immune responses against melanoma and offer a logical strategy to enhance immune rejection of melanoma.
Mon Apr 01 00:00:00 EDT 2013
Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.
Cardiovascular research
Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
Increased invasiveness of MMP-9-deficient tumors in two mouse models of neuroendocrine tumorigenesis.
Oncogene
Shchors K,Nozawa H,Xu J,Rostker F,Swigart-Brown L,Evan G,Hanahan D
14-0042 was used in Immunohistochemistry on frozen tissues to investigate why metalloproteinase inhibitors have been inefficacious in clinical settings.
Thu Jan 24 00:00:00 EST 2013
Aged mice exhibit a severely diminished CD8 T cell response following respiratory syncytial virus infection.
Journal of virology
Fulton RB,Weiss KA,Pewe LL,Harty JT,Varga SM
14-0042 was used in Flow cytometry/Cell sorting to investigate the extent to which CD8 T cell response to respiratory syncytial virus is altered with age, showing that age severely diminishes response.
Sun Dec 01 00:00:00 EST 2013
CD4+ T cells develop antiretroviral cytotoxic activity in the absence of regulatory T cells and CD8+ T cells.
Journal of virology
Manzke N,Akhmetzyanova I,Hasenkrug KJ,Trilling M,Zelinskyy G,Dittmer U
14-0042 was used in Flow cytometry/Cell sorting to investigate how both Tregs and CD8(+) T cells influence the cytotoxic activity of conventional CD4(+) T cells during an acute retroviral infection.
Sat Jun 01 00:00:00 EDT 2013
Temporal requirements for B cells in the establishment of CD4 T cell memory.
Journal of immunology (Baltimore, Md. : 1950)
Mollo SB,Zajac AJ,Harrington LE
14-0042 was used in Flow cytometry/Cell sorting to demonstrate the temporally and functionally distinct roles for B cells in regulating CD4 T cell responses.
Sun Dec 15 00:00:00 EST 2013
Retinoid X receptor agonists modulate Foxp3⁺ regulatory T cell and Th17 cell differentiation with differential dependence on retinoic acid receptor activation.
Journal of immunology (Baltimore, Md. : 1950)
Takeuchi H,Yokota-Nakatsuma A,Ohoka Y,Kagechika H,Kato C,Song SY,Iwata M
14-0042 was used in Immunohistochemistry to suggest that RXR stimulation modulates Foxp3+ iTreg and Th17 differentiation with differential dependence on RAR-mediated stimulation.
Tue Oct 01 00:00:00 EDT 2013
Myeloid-derived suppressor cells play crucial roles in the regulation of mouse collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Fujii W,Ashihara E,Hirai H,Nagahara H,Kajitani N,Fujioka K,Murakami K,Seno T,Yamamoto A,Ishino H,Kohno M,Maekawa T,Kawahito Y
14-0042 was used in Flow cytometry/Cell sorting to clarify that myeloid-derived suppressor cells are crucial in regulating the proinflammatory immune response in mouse collagen-induced arthritis.
Thu Aug 01 00:00:00 EDT 2013
Critical role of SAP in progression and reactivation but not maintenance of T cell-dependent humoral immunity.
Molecular and cellular biology
Zhong MC,Veillette A
14-0042 was used in Flow cytometry/Cell sorting to explore the therapeutic potential of blocking the SLAM-associated protein (SAP) for human autoimmune diseases.
Fri Mar 01 00:00:00 EST 2013
Examining T cells at vaccine sites of tumor-bearing hosts provides insights to dysfunctional T-cell immunity.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Barr KM,Jing W,Hallett WH,Gershan JA,Johnson BD
14-0042 was used in Flow cytometry/Cell sorting to examine immune effectors at vaccine sites to identify mechanisms responsible for the generation of ineffective antitumor immunity, providing insights to dysfunctional T-cell immunity.
Tue Jan 01 00:00:00 EST 2013
Interleukin-6 expands homeostatic space for peripheral T cells.
Cytokine
Hong C,Nam AS,Keller HR,Ligons DL,Park JY,Yoon HW,Park JJ,Luckey MA,Park JH
14-0042 was used in Flow cytometry/Cell sorting to investigate whether IL-6 promotes T cell survival and homeostasis in vivo, showing that it expands homeostatic space for peripheral T cells.
Fri Nov 01 00:00:00 EDT 2013
CD38 controls the innate immune response against Listeria monocytogenes.
Infection and immunity
Lischke T,Heesch K,Schumacher V,Schneider M,Haag F,Koch-Nolte F,Mittrücker HW
14-0042 was used in Flow cytometry/Cell sorting to evaluate the key enzymes governing the innate immune response.
Fri Nov 01 00:00:00 EDT 2013
Characterization of two distinct lymphoproliferative diseases caused by ectopic expression of the Notch ligand DLL4 on T cells.
PloS one
Xiong H,Maraver A,Latkowski JA,Henderson T,Schlessinger K,Ding Y,Shen J,Tadokoro CE,Lafaille JJ
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Mon Feb 23 00:00:00 EST 2015
Characterization of two distinct lymphoproliferative diseases caused by ectopic expression of the Notch ligand DLL4 on T cells.
PloS one
Xiong H,Maraver A,Latkowski JA,Henderson T,Schlessinger K,Ding Y,Shen J,Tadokoro CE,Lafaille JJ
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Mon Feb 23 00:00:00 EST 2015
Role of arginase 1 from myeloid cells in th2-dominated lung inflammation.
PloS one
Barron L,Smith AM,El Kasmi KC,Qualls JE,Huang X,Cheever A,Borthwick LA,Wilson MS,Murray PJ,Wynn TA
14-0042 was used in Flow cytometry/Cell sorting to investigate the contribution of arginase 1 to asthma pathogenesis.
Mon Dec 09 00:00:00 EST 2013
The adaptor molecule signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) is essential in mechanisms involving the Fyn tyrosine kinase for induction and progression of collagen-induced arthritis.
The Journal of biological chemistry
Zhong MC,Veillette A
14-0042 was used in Flow cytometry/Cell sorting to investigate how SAP plays an essential role in CIA because of Fyn-independent and Fyn-dependent effects on TFH cells and, possibly, other T cell types.
Fri Nov 01 00:00:00 EDT 2013
Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.
PloS one
Zanello G,Goethel A,Forster K,Geddes K,Philpott DJ,Croitoru K
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Thu Jul 31 00:00:00 EDT 2014
Local IL-17A potentiates early neutrophil recruitment to the respiratory tract during severe RSV infection.
PloS one
Stoppelenburg AJ,Salimi V,Hennus M,Plantinga M,Huis in 't Veld R,Walk J,Meerding J,Coenjaerts F,Bont L,Boes M
14-0042 was used in Flow cytometry/Cell sorting to elucidate whether local IL-17A facilitates the innate neutrophil infiltration into RSV infected lungs prior to adaptive immunity.
Tue Feb 24 00:00:00 EST 2015
Molecular definition of the identity and activation of natural killer cells.
Nature immunology
Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL
14-0042 was used in Flow cytometry/Cell sorting to systematically define the transcriptome of mouse natural killer cells in several contexts.
Mon Oct 01 00:00:00 EDT 2012
TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation.
Nature immunology
Zhang N,Bevan MJ
14-0042 was used in Flow cytometry/Cell sorting to propose that TGF-β signaling controls the self-reactivity of peripheral T cells but that in the absence of TGF-β signals, an added trigger such as lymphopenia is needed to drive overt autoimmune disease.
Sun May 27 00:00:00 EDT 2012
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
The Journal of experimental medicine
Billiard F,Lobry C,Darrasse-Jèze G,Waite J,Liu X,Mouquet H,DaNave A,Tait M,Idoyaga J,Leboeuf M,Kyratsous CA,Burton J,Kalter J,Klinakis A,Zhang W,Thurston G,Merad M,Steinman RM,Murphy AJ,Yancopoulos GD,Aifantis I,Skokos D
14-0042 was used in Flow cytometry/Cell sorting to investigate how Dll4-Notch signaling affects pro-T cell fate and thymic DC development, showing that it is a novel Flt3-independent pathway for DC development and autoimmunity.
Mon May 07 00:00:00 EDT 2012
T-cell trafficking facilitated by high endothelial venules is required for tumor control after regulatory T-cell depletion.
Cancer research
Hindley JP,Jones E,Smart K,Bridgeman H,Lauder SN,Ondondo B,Cutting S,Ladell K,Wynn KK,Withers D,Price DA,Ager A,Godkin AJ,Gallimore AM
14-0042 was used in Immunohistochemistry on frozen tissues to evaluate the mechanisms by which activated lymphocytes fail to infiltrate tumours, showing concordance between low tumour growth, high T-cell infiltration and the presence of high endothelial venules promoted by Treg cells.
Thu Nov 01 00:00:00 EDT 2012
Tissue exit: a novel control point in the accumulation of antigen-specific CD8 T cells in the influenza a virus-infected lung.
Journal of virology
Jennrich S,Lee MH,Lynn RC,Dewberry K,Debes GF
14-0042 was used in Flow cytometry/Cell sorting to find that in a murine model of influenza A virus infection, CD8 effector T cells migrated from the infected lung in a CCR7-dependent manner.
Sun Apr 01 00:00:00 EDT 2012
A TLR5 agonist enhances CD8(+) T cell-mediated graft-versus-tumor effect without exacerbating graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)
Ding X,Bian G,Leigh ND,Qiu J,McCarthy PL,Liu H,Aygun-Sunar S,Burdelya LG,Gudkov AV,Cao X
14-0042 was used in Flow cytometry/Cell sorting to investigate the effect of CBLB502 on graft-versus-tumour activity.
Thu Nov 15 00:00:00 EST 2012
NIK prevents the development of hypereosinophilic syndrome-like disease in mice independent of IKKα activation.
Journal of immunology (Baltimore, Md. : 1950)
Häcker H,Chi L,Rehg JE,Redecke V
14-0042 was used in Flow cytometry/Cell sorting to show that NF-κB-inducing kinase activity in non-haematopoietic cells controls Th2 cell development and prevents eosinophil-driven inflammatory disease.
Tue May 01 00:00:00 EDT 2012
CD70-driven costimulation induces survival or Fas-mediated apoptosis of T cells depending on antigenic load.
Journal of immunology (Baltimore, Md. : 1950)
Wensveen FM,Unger PP,Kragten NA,Derks IA,ten Brinke A,Arens R,van Lier RA,Eldering E,van Gisbergen KP
14-0042 was used in Flow cytometry/Cell sorting to investigate how BIm-dependent apoptosis is initiated in CD8 T cells.
Tue May 01 00:00:00 EDT 2012
MHC class Ib-restricted CD8 T cells differ in dependence on CD4 T cell help and CD28 costimulation over the course of mouse polyomavirus infection.
Journal of immunology (Baltimore, Md. : 1950)
Hofstetter AR,Ford ML,Sullivan LC,Wilson JJ,Hadley A,Brooks AG,Lukacher AE
14-0042-82 was used in Immunodepletion to investigate whether the expansion and maintenance components of the Q9:VP2.139-specific T cell response are differentially dependent on CD4 T cell help and CD28 costimulation.
Sun Apr 01 00:00:00 EDT 2012
Exposure to nicotine adversely affects the dendritic cell system and compromises host response to vaccination.
Journal of immunology (Baltimore, Md. : 1950)
Nouri-Shirazi M,Guinet E
14-0042 was used in Flow cytometry/Cell sorting to investigate the causal relationship between nicotine-induced dendritic cell alterations and host response to vaccines.
Thu Mar 01 00:00:00 EST 2012
Development and function of murine B cells lacking RANK.
Journal of immunology (Baltimore, Md. : 1950)
Perlot T,Penninger JM
14-0042 was used in Flow cytometry/Cell sorting to indicate that ablation of the RANKL-RANK pathway has no direct adverse effect on B cell physiology.
Wed Feb 01 00:00:00 EST 2012
Adeno-associated virus mediated delivery of Tregitope 167 ameliorates experimental colitis.
World journal of gastroenterology
van der Marel S,Majowicz A,Kwikkers K,van Logtenstein R,te Velde AA,De Groot AS,Meijer SL,van Deventer SJ,Petry H,Hommes DW,Ferreira V
14-0042 was used in Flow cytometry/Cell sorting to explore the anti-inflammatory potential of adeno-associated virus-mediated delivery of regulatory T-cell epitopes in a mouse model of experimental colitis.
Tue Aug 28 00:00:00 EDT 2012
Evaluation of Lassa virus vaccine immunogenicity in a CBA/J-ML29 mouse model.
Vaccine
Goicochea MA,Zapata JC,Bryant J,Davis H,Salvato MS,Lukashevich IS
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Tue Feb 14 00:00:00 EST 2012
The stalk domain and the glycosylation status of the activating natural killer cell receptor NKp30 are important for ligand binding.
The Journal of biological chemistry
Hartmann J,Tran TV,Kaudeer J,Oberle K,Herrmann J,Quagliano I,Abel T,Cohnen A,Gatterdam V,Jacobs A,Wollscheid B,Tampé R,Watzl C,Diefenbach A,Koch J
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Fri Sep 07 00:00:00 EDT 2012
Extra-thymic physiological T lineage progenitor activity is exclusively confined to cells expressing either CD127, CD90, or high levels of CD117.
PloS one
Saran N,Pommerencke J,Witzlau K,Regelin M,Krueger A
14-0042 was used in Flow cytometry/Cell sorting to suggest that a physiological thymic microenvironment does not optimally support T cell differentiation from triple negative precursors.
Mon Jun 18 00:00:00 EDT 2012
SH2D2A modulates T cell mediated protection to a B cell derived tumor in transgenic mice.
PloS one
Berge T,Grønningsæter IH,Lorvik KB,Abrahamsen G,Granum S,Sundvold-Gjerstad V,Corthay A,Bogen B,Spurkland A
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Tue Aug 26 00:00:00 EDT 2014
Vagaries of fluorochrome reporter gene expression in Foxp3+ regulatory T cells.
PloS one
Schallenberg S,Petzold C,Tsai PY,Sparwasser T,Kretschmer K
14-0042 was used in Flow cytometry/Cell sorting to perform a comparative analysis of thymic Treg cell development and peripheral compartments of mature Treg cells in various transgenic Foxp3-fluorochrome reporter mouse strains.
Thu Jan 10 00:00:00 EST 2013
An early reduction in Treg cells correlates with enhanced local inflammation in cutaneous leishmaniasis in CCR6-deficient mice.
PloS one
Barth T,Schmidt D,Botteron C,Nguyen TT,Ritter U,Männel DN,Lechner A
14-0042 was used in Flow cytometry/Cell sorting to analyse T cell subsets in the lymph nodes of CCR6-deficient mice over the course of Leishmania major infection.
Wed Mar 06 00:00:00 EST 2013
Lithium controls central nervous system autoimmunity through modulation of IFN-γ signaling.
PloS one
Rowse AL,Naves R,Cashman KS,McGuire DJ,Mbana T,Raman C,De Sarno P
14-0042 was used in Flow cytometry/Cell sorting to demonstrate a novel mechanism of GSK3 inhibitors as therapeutic agents in autoimmune neuroinflammation.
Thu Jun 27 00:00:00 EDT 2013
Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation.
Immunity
Wuerzberger-Davis SM,Chen Y,Yang DT,Kearns JD,Bates PW,Lynch C,Ladell NC,Yu M,Podd A,Zeng H,Huang TT,Wen R,Hoffmann A,Wang D,Miyamoto S
Published figure using CD4 monoclonal antibody (Product # 14-0042-82) in Flow Cytometry
Fri Feb 25 00:00:00 EST 2011
Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha.
Immunity
Hall JA,Cannons JL,Grainger JR,Dos Santos LM,Hand TW,Naik S,Wohlfert EA,Chou DB,Oldenhove G,Robinson M,Grigg ME,Kastenmayer R,Schwartzberg PL,Belkaid Y
14-0042 was used in Flow cytometry/Cell sorting to investigate the role of retinoic acid in responses to infection, showing that it is essential in the promotion of CD4(+) T cell effector responses.
Fri Mar 25 00:00:00 EDT 2011
Dysregulated generation of follicular helper T cells in the spleen triggers fatal autoimmune hepatitis in mice.
Gastroenterology
Aoki N,Kido M,Iwamoto S,Nishiura H,Maruoka R,Tanaka J,Watanabe T,Tanaka Y,Okazaki T,Chiba T,Watanabe N
14-0042 was used in Functional assays to identify induction sites, responsible T-cell subsets, and key molecules for induction of autoimmune hepatitis.
Fri Apr 01 00:00:00 EDT 2011
Delivery of progenitors to the thymus limits T-lineage reconstitution after bone marrow transplantation.
Blood
Zlotoff DA,Zhang SL,De Obaldia ME,Hess PR,Todd SP,Logan TD,Bhandoola A
14-0042 was used in Flow cytometry/Cell sorting to explain why T cells are among the last of the hematopoietic lineages to recover after bone marrow transplantation (BMT).
Thu Aug 18 00:00:00 EDT 2011
Recent thymic emigrants are biased against the T-helper type 1 and toward the T-helper type 2 effector lineage.
Blood
Hendricks DW,Fink PJ
14-0042 was used in Flow cytometry/Cell sorting to investigate the relationships between recent thymic emigrants and T-helper type 1 and 2 cells.
Thu Jan 27 00:00:00 EST 2011
Maternal T cells limit engraftment after in utero hematopoietic cell transplantation in mice.
The Journal of clinical investigation
Nijagal A,Wegorzewska M,Jarvis E,Le T,Tang Q,MacKenzie TC
14-0042 was used in Flow cytometry/Cell sorting to investigate whether maternal cells trafficking into the fetus impose the barrier to effective in utero hematopoietic cell transplantation, showing that maternal T cells limit engraftment.
Tue Feb 01 00:00:00 EST 2011
Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity.
The Journal of experimental medicine
Wei J,Loke P,Zang X,Allison JP
14-0042 was used in Flow cytometry/Cell sorting to investigate the role of B7x in maintaining peripheral tolerance and protecting from CD4 T cell-mediated autoimmunity.
Mon Aug 01 00:00:00 EDT 2011
T(H)17 cells mediate pulmonary collateral priming.
The Journal of allergy and clinical immunology
Albrecht M,Chen HC,Preston-Hurlburt P,Ranney P,Hoymann HG,Maxeiner J,Staudt V,Taube C,Bottomly HK,Dittrich AM
14-0042 was used in Flow cytometry/Cell sorting to analyze whether Th1-polarized pulmonary inflammation also facilitates priming towards new antigens.
Fri Jul 01 00:00:00 EDT 2011
Maximal T cell-mediated antitumor responses rely upon CCR5 expression in both CD4(+) and CD8(+) T cells.
Cancer research
González-Martín A,Gómez L,Lustgarten J,Mira E,Mañes S
14-0042 was used in Flow cytometry/Cell sorting to investigate the relevance of the chemokine receptor CCR5 in tumoural immune control.
Mon Aug 15 00:00:00 EDT 2011
S1P is associated with protection in human and experimental cerebral malaria.
Molecular medicine (Cambridge, Mass.)
Finney CA,Hawkes CA,Kain DC,Dhabangi A,Musoke C,Cserti-Gazdewich C,Oravecz T,Liles WC,Kain KC
14-0042 was used in Flow cytometry/Cell sorting to study dysregulation of the S1P pathway in the pathogenesis of human and murine cerebral malaria.
Tue Dec 27 00:00:00 EST 2011
Complement regulates CD4 T-cell help to CD8 T cells required for murine allograft rejection.
The American journal of pathology
Vieyra M,Leisman S,Raedler H,Kwan WH,Yang M,Strainic MG,Medof ME,Heeger PS
14-0042 was used in Immunohistochemistry to indicate that heightened production and activation of immune cell-derived complement bypasses the need for CD40/CD154 interactions.
Mon Aug 01 00:00:00 EDT 2011
Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model.
Journal of immunology (Baltimore, Md. : 1950)
Van Belle TL,Esplugues E,Liao J,Juntti T,Flavell RA,von Herrath MG
14-0042 was used in Flow cytometry/Cell sorting to elucidate the role of IL-17 in viral infections and type 1 diabetes.
Thu Sep 15 00:00:00 EDT 2011
Rescue of tumor-infiltrating lymphocytes from activation-induced cell death enhances the antitumor CTL response in CD5-deficient mice.
Journal of immunology (Baltimore, Md. : 1950)
Tabbekh M,Franciszkiewicz K,Haouas H,Lécluse Y,Benihoud K,Raman C,Mami-Chouaib F
14-0042-82 was used in Flow Cytometry to compare the T cell response to the B16F10 melanoma engrafted into CD5-deficient and wild-type C57BL/6 mice.
Fri Jul 01 00:00:00 EDT 2011
Cutting edge: Generation of colitogenic Th17 CD4 T cells is enhanced by IL-17+ γδ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Do JS,Visperas A,Dong C,Baldwin WM,Min B
14-0042 was used in Flow cytometry/Cell sorting to elucidate a cellular mechanism by which colitogenic Th17 immunity arises in vivo.
Fri Apr 15 00:00:00 EDT 2011
TLR4 signaling via MyD88 and TRIF differentially shape the CD4+ T cell response to Porphyromonas gingivalis hemagglutinin B.
Journal of immunology (Baltimore, Md. : 1950)
Gaddis DE,Michalek SM,Katz J
14-0042 was used in Flow cytometry/Cell sorting to investigate how the stimulation of dendritic cells with recombinant haemagglutinin B affects the activation and differentiation of T cells in mice.
Sun May 15 00:00:00 EDT 2011
Multiple CD4+ T cell subsets produce immunomodulatory IL-10 during respiratory syncytial virus infection.
Journal of immunology (Baltimore, Md. : 1950)
Weiss KA,Christiaansen AF,Fulton RB,Meyerholz DK,Varga SM
14-0042 was used in Flow cytometry/Cell sorting to evaluate the role of IL-10 in the modulation of the respiratory syncytial virus-specific immune response.
Thu Sep 15 00:00:00 EDT 2011
Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950)
Chen YG,Scheuplein F,Driver JP,Hewes AA,Reifsnyder PC,Leiter EH,Serreze DV
14-0042 was used in Flow cytometry/Cell sorting to demonstrate the presence of a T1D resistance gene closely linked to the ablated Cd38 allele in the previously reported NOD stock also lacking ART2.
Fri Apr 01 00:00:00 EDT 2011
Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.
Nature communications
Mkhikian H,Grigorian A,Li CF,Chen HL,Newton B,Zhou RW,Beeton C,Torossian S,Tatarian GG,Lee SU,Lau K,Walker E,Siminovitch KA,Chandy KG,Yu Z,Dennis JW,Demetriou M
14-0042 was used in Flow cytometry/Cell sorting to discover that genetic and the environment converge to dysregulate N-glycosylation in multiple sclerosis.
Tue Sep 20 00:00:00 EDT 2011
FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia.
PloS one
Liesz A,Sun L,Zhou W,Schwarting S,Mracsko E,Zorn M,Bauer H,Sommer C,Veltkamp R
14-0042 was used in Flow cytometry/Cell sorting to detect a reduction of lymphocyte brain invasion by FTY720.
Fri Oct 14 00:00:00 EDT 2011
N-acetylglucosamine inhibits T-helper 1 (Th1)/T-helper 17 (Th17) cell responses and treats experimental autoimmune encephalomyelitis.
The Journal of biological chemistry
Grigorian A,Araujo L,Naidu NN,Place DJ,Choudhury B,Demetriou M
14-0042 was used in Flow cytometry/Cell sorting to demonstrate that oral GlcNAc inhibits T-helper 1 and 17 responses, suppressing experimental autoimmune encephalomyelitis progression.
Fri Nov 18 00:00:00 EST 2011
The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma.
American journal of respiratory and critical care medicine
Naus S,Blanchet MR,Gossens K,Zaph C,Bartsch JW,McNagny KM,Ziltener HJ
14-0042 was used in Flow cytometry/Cell sorting to determine that ADAM8 plays a crucial proinflammatory role in airway inflammation.
Tue Jun 15 00:00:00 EDT 2010
Separation of graft-versus-host disease from graft-versus-leukemia responses by targeting CC-chemokine receptor 7 on donor T cells.
Blood
Coghill JM,Carlson MJ,Panoskaltsis-Mortari A,West ML,Burgents JE,Blazar BR,Serody JS
14-0042 was used in Flow cytometry/Cell sorting to investigate the role of MHC disparity between donor and recipient, in the attenuated graft-versus-host disease responses of murine T cells lacking CCR7.
Thu Jun 10 00:00:00 EDT 2010
Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma.
Cancer research
Klages K,Mayer CT,Lahl K,Loddenkemper C,Teng MW,Ngiow SF,Smyth MJ,Hamann A,Huehn J,Sparwasser T
14-0042 was used in Flow cytometry/Cell sorting to suggest that selective Treg targeting strategies combined with vaccinations against tumor-associated (self) antigens have the potential to evoke efficient antitumor responses without inducing overt autoimmunity.
Fri Oct 15 00:00:00 EDT 2010
Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance.
Cancer research
Chin AI,Miyahira AK,Covarrubias A,Teague J,Guo B,Dempsey PW,Cheng G
14-0042 was used in Flow cytometry/Cell sorting to delineate the importance of IFNAR-dependent functions in TLR3-mediated tumour suppression.
Thu Apr 01 00:00:00 EDT 2010
Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease.
Journal of immunology (Baltimore, Md. : 1950)
Gibbert K,Dietze KK,Zelinskyy G,Lang KS,Barchet W,Kirschning CJ,Dittmer U
14-0042 was used in Flow cytometry/Cell sorting to investigate the mode of action of poly(I:C) in antiretroviral immunotherapy.
Mon Nov 15 00:00:00 EST 2010
Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3.
Journal of immunology (Baltimore, Md. : 1950)
Kim S,Prout M,Ramshaw H,Lopez AF,LeGros G,Min B
14-0042 was used in Flow cytometry/Cell sorting to investigate the importance of IL-3 in recruiting basophils into the draining lymph nodes and inducing Th2 immune responses following helminth infection.
Mon Feb 01 00:00:00 EST 2010
Slam haplotypes modulate the response to lipopolysaccharide in vivo through control of NKT cell number and function.
Journal of immunology (Baltimore, Md. : 1950)
Aktan I,Chant A,Borg ZD,Damby DE,Leenstra PC,Lilley GW,Petty J,Suratt BT,Teuscher C,Wakeland EK,Poynter ME,Boyson JE
14-0042 was used in Flow cytometry/Cell sorting to investigate the effect of Slam haplotypes on NKT cells.
Thu Jul 01 00:00:00 EDT 2010
Bronchial epithelial cells produce IL-5: implications for local immune responses in the airways.
Cellular immunology
Wu CA,Peluso JJ,Zhu L,Lingenheld EG,Walker ST,Puddington L
14-0042 was used in Immunofluorescence to investigate how IL-5 production by BEC can impact the microenvironment of the lung, modifying pathological and protective immune responses in the airways.
Wed Sep 01 00:00:00 EDT 2010
Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60.
Blood
Ryu SJ,Jung KM,Yoo HS,Kim TW,Kim S,Chang J,Choi EY
14-0042 was used in Flow cytometry/Cell sorting to provide insight into the control of minor H antigen-specific CD8 T-cell responses, to maximize the graft-versus-leukemia response.
Thu Apr 30 00:00:00 EDT 2009
Identification of cancer stem cells in a Tax-transgenic (Tax-Tg) mouse model of adult T-cell leukemia/lymphoma.
Blood
Yamazaki J,Mizukami T,Takizawa K,Kuramitsu M,Momose H,Masumi A,Ami Y,Hasegawa H,Hall WW,Tsujimoto H,Hamaguchi I,Yamaguchi K
14-0042 was used in Immunohistochemistry to investigate the existence of chemotherapy-resistance cancer stem cells (CSCs) in adult T-cell leukemia/lymphoma (ATL), showing a candidate population that overlaps with CD38(-)/CD71(-)/CD117(+) cell population, and that transplantation of CSCs could regenerate the original lymphoma and potentially are derived from pro-T cells or early hematopoietic progenitor cells.
Thu Sep 24 00:00:00 EDT 2009
CSF-1 signals directly to renal tubular epithelial cells to mediate repair in mice.
The Journal of clinical investigation
Menke J,Iwata Y,Rabacal WA,Basu R,Yeung YG,Humphreys BD,Wada T,Schwarting A,Stanley ER,Kelley VR
14-0042 was used in Immunohistochemistry on frozen tissues to assess whether CSF-1 has a therapeutic effect following ischaemia/reperfusion injury in mice.
Sat Aug 01 00:00:00 EDT 2009
Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus-infected mice.
The Journal of experimental medicine
GeurtsvanKessel CH,Willart MA,Bergen IM,van Rijt LS,Muskens F,Elewaut D,Osterhaus AD,Hendriks R,Rimmelzwaan GF,Lambrecht BN
14-0042 was used in Immunohistochemistry to study the role of CD11c+ dendritic cells in tertiary lymphoid organs organisation.
Mon Oct 26 00:00:00 EDT 2009
CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche.
Proceedings of the National Academy of Sciences of the United States of America
Chevrier S,Genton C,Kallies A,Karnowski A,Otten LA,Malissen B,Malissen M,Botto M,Corcoran LM,Nutt SL,Acha-Orbea H
14-0042 was used in Immunofluorescence in immunohistochemistry on frozen tissues to explain why CD93, a receptor expressed during early B-cell development, is reinduced during plasma-cell differentiation.
Tue Mar 10 00:00:00 EDT 2009
Differential requirements of MHC and of DCs for endogenous proliferation of different T-cell subsets in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Do JS,Min B
14-0042 was used in Flow cytometry/Cell sorting to investigate the conditions and requirements of MHC and DCs for endogenous proliferation of different T-cell subsets.
Tue Dec 01 00:00:00 EST 2009
The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection.
PLoS pathogens
Shimada K,Chen S,Dempsey PW,Sorrentino R,Alsabeh R,Slepenkin AV,Peterson E,Doherty TM,Underhill D,Crother TR,Arditi M
14-0042 was used in Flow cytometry/Cell sorting to investigate the role of the Nod/Rip2 pathway in responses to Chlamydophila pneumoniae infection, showing that it is essential for host defences against pneumonia.
Wed Apr 01 00:00:00 EDT 2009
Coxsackievirus B3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the MHC class I pathway.
PLoS pathogens
Kemball CC,Harkins S,Whitmire JK,Flynn CT,Feuer R,Whitton JL
14-0042 was used in Flow cytometry/Cell sorting to evaluate in vitro and in vivo antigen presentation by coxsackievirus B3, showing that it inhibits antigen presentation in vivo.
Thu Oct 01 00:00:00 EDT 2009
Toll-like receptor 4 deficiency increases disease and mortality after mouse hepatitis virus type 1 infection of susceptible C3H mice.
Journal of virology
Khanolkar A,Hartwig SM,Haag BA,Meyerholz DK,Harty JT,Varga SM
14-0042 was used in Flow cytometry/Cell sorting to demonstrate that TLR4 plays an important role in respiratory CoV pathogenesis.
Tue Sep 01 00:00:00 EDT 2009
Chronic CD70-driven costimulation impairs IgG responses by instructing T cells to inhibit germinal center B cell formation through FasL-Fas interactions.
Journal of immunology (Baltimore, Md. : 1950)
Beishuizen CR,Kragten NA,Boon L,Nolte MA,van Lier RA,van Gisbergen KP
14-0042 was used in Flow cytometry/Cell sorting to investigate the mechanism by which CD70 expression induces T cell-driven disruption of neutralising Ab responses, showing that this occurs by instructing T cells to inhibit germinal center B cell formation.
Sun Nov 15 00:00:00 EST 2009
Small interfering RNA against transcription factor STAT6 inhibits allergic airway inflammation and hyperreactivity in mice.
Journal of immunology (Baltimore, Md. : 1950)
Darcan-Nicolaisen Y,Meinicke H,Fels G,Hegend O,Haberland A,Kühl A,Loddenkemper C,Witzenrath M,Kube S,Henke W,Hamelmann E
14-0042 was used in Immunohistochemistry to show that targeting STAT6 by siRNA effectively blocks the development of cardinal features of allergic airway disease.
Mon Jun 15 00:00:00 EDT 2009
Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950)
Schaeffer M,Han SJ,Chtanova T,van Dooren GG,Herzmark P,Chen Y,Roysam B,Striepen B,Robey EA
14-0042 was used in Flow cytometry/Cell sorting to directly observe the dynamics of T cell-parasite interactions within living tissue and further understand immune responses to persistent pathogens in the brain.
Fri May 15 00:00:00 EDT 2009
Increasing the CD4+ T cell precursor frequency leads to competition for IFN-gamma thereby degrading memory cell quantity and quality.
Journal of immunology (Baltimore, Md. : 1950)
Whitmire JK,Benning N,Eam B,Whitton JL
14-0042 was used in Flow cytometry/Cell sorting to investigate the relationship between the frequency of CD4(+) T cells and memory cells generated, showing that increased frequency leads to competition for IFN-gamma thereby degrading memory cell quantity and quality.
Thu May 15 00:00:00 EDT 2008
Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease.
The Journal of experimental medicine
Sather BD,Treuting P,Perdue N,Miazgowicz M,Fontenot JD,Rudensky AY,Campbell DJ
14-0042 was used in Flow cytometry/Cell sorting to investigate the factors which impact regulatory T cell homing receptor expression, tissue distribution and peripheral tolerance maintenance.
Mon Jun 11 00:00:00 EDT 2007
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling.
Proceedings of the National Academy of Sciences of the United States of America
Tsuji M,Shinkura R,Kuroda K,Yabe D,Honjo T
14-0042-82 was used in Flow Cytometry to o investigate where and how Notch regulates early T cell differentiation by using specific up-regulation of Notch signaling by Mint knockout.
Tue Jan 30 00:00:00 EST 2007
Amelioration of coxsackievirus B3-mediated myocarditis by inhibition of tissue inhibitors of matrix metalloproteinase-1.
The American journal of pathology
Crocker SJ,Frausto RF,Whitmire JK,Benning N,Milner R,Whitton JL
14-0042 was used in Flow cytometry/Cell sorting to show that TIMP-1 expression is induced in the myocardium by CVB3 infection.
Sat Dec 01 00:00:00 EST 2007
IL-10 regulates movement of intestinally derived CD4+ T cells to the liver.
Journal of immunology (Baltimore, Md. : 1950)
Bliss SK,Bliss SP,Beiting DP,Alcaraz A,Appleton JA
Fri Jun 15 00:00:00 EDT 2007
Control of T Cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis.
The Journal of biological chemistry
Grigorian A,Lee SU,Tian W,Chen IJ,Gao G,Mendelsohn R,Dennis JW,Demetriou M
14-0042 was used in Flow cytometry/Cell sorting to investigate how the environment influences susceptibility to autoimmunity, showing that autoimmunity can be controlled through metabolite flux to N-glycan biosynthesis.
Fri Jul 06 00:00:00 EDT 2007
N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration.
The Journal of biological chemistry
Lee SU,Grigorian A,Pawling J,Chen IJ,Gao G,Mozaffar T,McKerlie C,Demetriou M
14-0042 was used in Flow cytometry/Cell sorting to identify hypomorphic Golgi processing as an inherited trait that determines susceptibility to EAE and provides a unique spontaneous model of MS.
Fri Nov 16 00:00:00 EST 2007
Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}.
Proceedings of the National Academy of Sciences of the United States of America
Rubinstein MP,Kovar M,Purton JF,Cho JH,Boyman O,Surh CD,Sprent J
Tue Jun 13 00:00:00 EDT 2006
Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen.
The Journal of experimental medicine
Knoechel B,Lohr J,Kahn E,Bluestone JA,Abbas AK
14-0042 was used in Flow cytometry/Cell sorting to show peripheral T cell reaction to a systemic antigen goes through a phase of effector cell-mediated pathology followed by T reg cell-mediated recovery, and both require IL-2.
Mon Nov 21 00:00:00 EST 2005
Bone marrow is a reservoir for CD4+CD25+ regulatory T cells that traffic through CXCL12/CXCR4 signals.
Cancer research
Zou L,Barnett B,Safah H,Larussa VF,Evdemon-Hogan M,Mottram P,Wei S,David O,Curiel TJ,Zou W
14-0042 was used in Flow cytometry/Cell sorting to study the homeostatic and pathologic trafficking of Treg cells.
Mon Nov 15 00:00:00 EST 2004
Bone marrow is a reservoir for CD4+CD25+ regulatory T cells that traffic through CXCL12/CXCR4 signals.
Cancer research
Zou L,Barnett B,Safah H,Larussa VF,Evdemon-Hogan M,Mottram P,Wei S,David O,Curiel TJ,Zou W
14-0042 was used in Flow cytometry/Cell sorting to study the homeostatic and pathologic trafficking of Treg cells.
Mon Nov 15 00:00:00 EST 2004
