Product References
Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function.
British journal of pharmacology
Liao W,Foo HYC,Tran TNQ,Chai CLL,Wong WSF
45-0042-82 was used in Flow cytometry/Cell sorting to demonstrate for the first time that CalD is a novel anti-inflammatory natural compound for allergic asthma that modulates AM function.
Sat Apr 01 00:00:00 EDT 2023
TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions.
Frontiers in immunology
O'Neill TJ,Gewies A,Seeholzer T,Krappmann D
45-0042-82 was used in Flow Cytometry to demonstrate that TRAF6 deletion or MALT1 paracaspase inactivation are highly interdependent in causing the distinct immune pathologies.
Mon Feb 13 00:00:00 EST 2023
Mesenchymal stromal cells equipped by IFNα empower T cells with potent anti-tumor immunity.
Oncogene
Zhang T,Wang Y,Li Q,Lin L,Xu C,Xue Y,Hu M,Shi Y,Wang Y
45-0042-82 was used in Flow Cytometry to conclude that IFNα-MSCs represent a novel tumor immunotherapy strategy, especially when combined with PD-L1 blockade.
Tue Mar 01 00:00:00 EST 2022
Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain.
eLife
Kovacs MA,Cowan MN,Babcock IW,Sibley LA,Still K,Batista SJ,Labuzan SA,Sethi I,Harris TH
45-0042-82 was used in Flow cytometry/Cell sorting to reveal that CNS lymphatic drainage supports the development of peripheral T cell responses against T. gondii but remains dispensable for immune protection of the brain.
Wed Dec 21 00:00:00 EST 2022
A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts.
Immunity
Zindl CL,Witte SJ,Laufer VA,Gao M,Yue Z,Janowski KM,Cai B,Frey BF,Silberger DJ,Harbour SN,Singer JR,Turner H,Lund FE,Vallance BA,Rosenberg AF,Schoeb TR,Chen JY,Hatton RD,Weaver CT
45-0042-82 was used in Flow cytometry/Cell sorting to demonstrate spatiotemporal differences in the production and action of IL-22 by ILCs and T cells during infection and reveal an indispensable role for IL-22-producing T cells in the protection of the intestinal crypts.
Tue Mar 08 00:00:00 EST 2022
Th2 single-cell heterogeneity and clonal distribution at distant sites in helminth-infected mice.
eLife
Radtke D,Thuma N,Schülein C,Kirchner P,Ekici AB,Schober K,Voehringer D
45-0042-82 was used in Flow cytometry/Cell sorting to provide insights in Th2 cell subset diversity and clonal relatedness in distant organs.
Thu Aug 11 00:00:00 EDT 2022
NKT cells adopt a glutamine-addicted phenotype to regulate their homeostasis and function.
Cell reports
Kumar A,Yarosz EL,Andren A,Zhang L,Lyssiotis CA,Chang CH
45-0042-82 was used in Flow cytometry/Cell sorting to highlight a distinct metabolic requirement of NKT cells compared with CD4 T cells, which may have therapeutic implications in the treatment of certain nutrient-restricted diseases.
Tue Oct 25 00:00:00 EDT 2022
Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation.
Immunity
Medina CB,Chiu YH,Stremska ME,Lucas CD,Poon I,Tung KS,Elliott MR,Desai B,Lorenz UM,Bayliss DA,Ravichandran KS
45-0042-82 was used in Flow cytometry/Cell sorting to uncover an immunoregulatory role for the nucleotide release channel, Panx1, in T cell crosstalk during airway disease.
Tue Aug 10 00:00:00 EDT 2021
The ubiquitin ligase Peli1 inhibits ICOS and thereby Tfh-mediated immunity.
Cellular & molecular immunology
Huang X,Hao S,Liu J,Huang Y,Liu M,Xiao C,Wang Y,Pei S,Yu T,Xu J,Wang H,Dai D,Su X,Xiao Y
45-0042-82 was used in Flow Cytometry to elucidate the molecular mechanisms regulating T follicular helper cells.
Thu Apr 01 00:00:00 EDT 2021
Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies.
The Journal of experimental medicine
Heindl S,Ricci A,Carofiglio O,Zhou Q,Arzberger T,Lenart N,Franzmeier N,Hortobagyi T,Nelson PT,Stowe AM,Denes A,Edbauer D,Liesz A
45-0042-82 was used in Flow Cytometry to show a persistent accumulation of T cells in mice and human autopsy samples for more than 1 mo after stroke.
Mon Aug 02 00:00:00 EDT 2021
DNA Methylation Patterns in T Cells of Naïve and Influenza A Virus-Infected Mice Developmentally Exposed to an Aryl Hydrocarbon Receptor Ligand.
Environmental health perspectives
Burke CG,Myers JR,Post CM,Boulé LA,Lawrence BP
45-0042-82 was used in Flow Cytometry to identify cellular mechanisms that drive impaired CD4+ T-cell responses later in life following maternal exposure to an exogenous aryl hydrocarbon receptor. ligand.
Fri Jan 01 00:00:00 EST 2021
Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ.
Aging cell
Webb LMC,Fra-Bido S,Innocentin S,Matheson LS,Attaf N,Bignon A,Novarino J,Fazilleau N,Linterman MA
45-0042-82 was used in Flow Cytometry to show increased formation of Tfh precursors (pre-Tfh) but no associated increase in germinal centre (GC)-Tfh cells in aged mice, suggesting age-driven promotion of only early Tfh cell differentiation.
Fri Jan 01 00:00:00 EST 2021
Romidepsin (FK228) regulates the expression of the immune checkpoint ligand PD-L1 and suppresses cellular immune functions in colon cancer.
Cancer immunology, immunotherapy : CII
Shi Y,Fu Y,Zhang X,Zhao G,Yao Y,Guo Y,Ma G,Bai S,Li H
45-0042 was used in Flow cytometry/Cell sorting to explore the anti-tumor effects and influence on immune responses of romidepsin in colon cancer.
Fri Jan 01 00:00:00 EST 2021
Fine particulate matter induces airway inflammation by disturbing the balance between Th1/Th2 and regulation of GATA3 and Runx3 expression in BALB/c mice.
Molecular medicine reports
Pang L,Yu P,Liu X,Fan Y,Shi Y,Zou S
45-0042-82 was used in Flow Cytometry to demonstrate the effect of particulate matter on the response of Th1 and Th2 cells leading to an allergic airway response.
Sat May 01 00:00:00 EDT 2021
Antitumor efficacy of a neoantigen cancer vaccine delivered by electroporation is influenced by microbiota composition.
Oncoimmunology
Lione L,Salvatori E,Petrazzuolo A,Massacci A,Maggio R,Confroti A,Compagnone M,Aurisicchio L,Ciliberto G,Palombo F
45-0042-82 was used in Flow cytometry/Cell sorting to find that decreased microbiota diversity induced by prolonged antibiotic (ATB) treatment is associated with higher intratumor specific immune responses and consequently to a better antitumor effect induced by neoantigen cancer vaccines (NCVs) delivered by DNA-EP.
Tue Mar 23 00:00:00 EDT 2021
Robust induction of TRMs by combinatorial nanoshells confers cross-strain sterilizing immunity against lethal influenza viruses.
Molecular therapy. Methods & clinical development
Lin PH,Liang CY,Yao BY,Chen HW,Pan CF,Wu LL,Lin YH,Hsu YS,Liu YH,Chen PJ,Hu CJ,Yang HC
45-0042-82 was used in Flow Cytometry to demonstrate safe and potent induction of lung-resident memory T cells in a biodegradable, virus-mimicking structure.
Fri Jun 11 00:00:00 EDT 2021
Thymopentin treatment of murine premature ovarian failure via attenuation of immune cell activity and promotion of the BMP4/Smad9 signalling pathway.
International journal of medical sciences
Zhu X,Liu J,Pan H,Geng Z,Huang W,Liu T,Zhang B
45-0042-82 was used in Flow cytometry/Cell sorting to indicate somedifferences in gene transcription between the TP-5 intervention group and the control group.
Tue Mar 15 00:00:00 EDT 2022
Epigenetic Modulation of Class-Switch DNA Recombination to IgA by miR-146a Through Downregulation of Smad2, Smad3 and Smad4.
Frontiers in immunology
Casali P,Li S,Morales G,Daw CC,Chupp DP,Fisher AD,Zan H
45-0042-82 was used in flow cytometry to conclude that, by inhibiting Smad2, Smad3 and Smad4 expression, miR-146a plays an important and B cell intrinsic role in modulation of CSR to IgA and the IgA antibody response.
Tue Feb 08 00:00:00 EST 2022
A macrophage-T cell coculture model for severe tissue injury-induced T cell death.
STAR protocols
Zhu J,Cao J,Liesz A,Roth S
45-0042-82 was used in Flow Cytometry to present an in vitro model for cell-cell interactions between innate (macrophages) and adaptive (T cells) immune cells.
Fri Dec 17 00:00:00 EST 2021
Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases.
iScience
Xu Y,Liu E,Xie X,Wang J,Zheng H,Ju Y,Chen L,Li C,Zhou X,Li Z,Li X,Meng S
45-0042-82 was used in Flow cytometry/Cell sorting to show that gp96 immunization restricted antibody-induced and Th-induced autoimmune diseases by integrating Treg expansion and activation, indicating its potential clinical usefulness against autoimmune diseases.
Fri Dec 17 00:00:00 EST 2021
An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development.
Immunity
Chopp LB,Gopalan V,Ciucci T,Ruchinskas A,Rae Z,Lagarde M,Gao Y,Li C,Bosticardo M,Pala F,Livak F,Kelly MC,Hannenhalli S,Bosselut R
45-0042-82 was used in Flow Cytometry to identify mouse and human αβ thymocyte developmental trajectories.
Tue Dec 15 00:00:00 EST 2020
An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development.
Immunity
Chopp LB,Gopalan V,Ciucci T,Ruchinskas A,Rae Z,Lagarde M,Gao Y,Li C,Bosticardo M,Pala F,Livak F,Kelly MC,Hannenhalli S,Bosselut R
45-0042-82 was used in Flow Cytometry to identify mouse and human αβ thymocyte developmental trajectories.
Tue Dec 15 00:00:00 EST 2020
Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation.
PLoS biology
Kobia FM,Preusse K,Dai Q,Weaver N,Hass MR,Chaturvedi P,Stein SJ,Pear WS,Yuan Z,Kovall RA,Kuang Y,Eafergen N,Sprinzak D,Gebelein B,Brunskill EW,Kopan R
45-0042 was used in Flow cytometry/Cell sorting to highlight the role of the environment in malignancy and colitis and is consistent with Notch-dependent anti-parasite immune responses being compromised in Notch dimer-deficient animals.
Thu Oct 01 00:00:00 EDT 2020
Fibroblast growth factor-inducible 14 mediates macrophage infiltration in heart to promote pressure overload-induced cardiac dysfunction.
Life sciences
Unudurthi SD,Nassal DM,Patel NJ,Thomas E,Yu J,Pierson CG,Bansal SS,Mohler PJ,Hund TJ
45-0042 was used in Flow cytometry/Cell sorting to investigate the role of TWEAK/Fn14 pathway in promoting cardiac inflammation under non ischemic stress conditions.
Wed Apr 15 00:00:00 EDT 2020
GRIM-19 Ameliorates Multiple Sclerosis in a Mouse Model of Experimental Autoimmune Encephalomyelitis with Reciprocal Regulation of IFNγ/Th1 and IL-17A/Th17 Cells.
Immune network
Moon J,Lee SH,Lee SY,Ryu J,Jhun J,Choi J,Kim GN,Roh S,Park SH,Cho ML
45-0042-80 was used in Immunohistochemistry (Frozen) to explore whether GRIM-19 ameliorated MS by increasing the levels of inflammatory cytokines and immune cells.
Thu Oct 01 00:00:00 EDT 2020
Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer.
Nature communications
Buqué A,Bloy N,Perez-Lanzón M,Iribarren K,Humeau J,Pol JG,Levesque S,Mondragon L,Yamazaki T,Sato A,Aranda F,Durand S,Boissonnas A,Fucikova J,Senovilla L,Enot D,Hensler M,Kremer M,Stoll G,Hu Y,Massa C,Formenti SC,Seliger B,Elemento O,Spisek R,André F,Zitvogel L,Delaloge S,Kroemer G,Galluzzi L
45-0042 was used in Flow cytometry/Cell sorting to identify NAM as a potential strategy for the prevention and treatment of HR+ BC.
Thu Jul 30 00:00:00 EDT 2020
Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia.
Cell reports
Xu G,van Bruggen R,Gualtieri CO,Moradin N,Fois A,Vallerand D,De Sa Tavares Russo M,Bassenden A,Lu W,Tam M,Lesage S,Girouard H,Avizonis DZ,Deblois G,Prchal JT,Stevenson M,Berghuis A,Muir T,Rabinowitz J,Vidal SM,Fodil N,Gros P
45-0042 was used in Flow cytometry/Cell sorting to highlight the importance of BPGM as a regulator of hemoglobin/oxyhemoglobin in malaria pathogenesis and suggest a new potential malaria therapeutic target.
Tue Sep 22 00:00:00 EDT 2020
Nuclear imaging-guided PD-L1 blockade therapy increases effectiveness of cancer immunotherapy.
Journal for immunotherapy of cancer
Gao H,Wu Y,Shi J,Zhang X,Liu T,Hu B,Jia B,Wan Y,Liu Z,Wang F
45-0042 was used in Flow cytometry/Cell sorting to demonstrate that 99mTc-MY1523 SPECT/CT allowed a real-time, quantitative and dynamic mapping of PD-L1 expression in vivo, and the imaging-guided PD-L1 blockade immunotherapy significantly enhanced the therapeutic efficacy.
Sun Nov 01 00:00:00 EDT 2020
Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells.
Cell reports
Shin B,Benavides GA,Geng J,Koralov SB,Hu H,Darley-Usmar VM,Harrington LE
45-0042 was used in Flow cytometry/Cell sorting to study the role of mitochondrial oxidative phosphorylation in pathogenic Th17 differentiation.
Tue Feb 11 00:00:00 EST 2020
Loss of FGFR3 Delays Acute Myeloid Leukemogenesis by Programming Weakly Pathogenic CD117-Positive Leukemia Stem-Like Cells.
Frontiers in pharmacology
Guo C,Ran Q,Sun C,Zhou T,Yang X,Zhang J,Pang S,Xiao Y
45-0042-82 was used in Flow Cytometry to find that FGFR3 had a novel regulatory mechanism for the stemness of LSCs in AML, and provided a promising anti-leukemia approach by interrupting FGFR3.
Tue Feb 16 00:00:00 EST 2021
CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation.
Frontiers in immunology
Shapiro MR,Yeh WI,Longfield JR,Gallagher J,Infante CM,Wellford S,Posgai AL,Atkinson MA,Campbell-Thompson M,Lieberman SM,Serreze DV,Geurts AM,Chen YG,Brusko TM
45-0042 was used in Flow cytometry/Cell sorting to support an important role for CD226 in type 1 diabetes development by modulating thymic T cell selection as well as impacting peripheral memory/effector CD8+ T cell activation and function.
Wed May 26 00:00:00 EDT 2021
5-Azacytidine Potentiates Anti-tumor Immunity in a Model of Pancreatic Ductal Adenocarcinoma.
Frontiers in immunology
Ebelt ND,Zuniga E,Johnson BL,Diamond DJ,Manuel ER
45-0042 was used in Flow cytometry/Cell sorting to show that transposable elements (TE) and gene encoded, tumor-associated antigens (TAA) are significantly upregulated during the transition from pre-malignancy to malignancy in an inducible model of pancreatic ductal adenocarcinoma (PDAC).
Fri Mar 26 00:00:00 EDT 2021
Mouse Double Minute 2 Homolog-Mediated Ubiquitination Facilitates Forkhead Box P3 Stability and Positively Modulates Human Regulatory T Cell Function.
Frontiers in immunology
Wang A,Yang M,Liang R,Zhu F,Zhu F,Liu X,Han Y,Lin R,Wang X,Li D,Li H,Yuan X,Zhao H,Li B
45-0042 was used in Flow cytometry/Cell sorting to investigate how mouse double minute 2 homolog effects the function of regulatory T cells.
Mon Apr 05 00:00:00 EDT 2021
Resolving Fates and Single-Cell Transcriptomes of Hematopoietic Stem Cell Clones by PolyloxExpress Barcoding.
Cell stem cell
Pei W,Shang F,Wang X,Fanti AK,Greco A,Busch K,Klapproth K,Zhang Q,Quedenau C,Sauer S,Feyerabend TB,Höfer T,Rodewald HR
45-0042 was used in Flow cytometry/Cell sorting to develop the PolyloxExpress allele, enabling Cre-recombinase-dependent RNA barcoding in situ.
Thu Sep 03 00:00:00 EDT 2020
Downregulation of Blimp1 inhibits the maturation of bone marrow-derived dendritic cells.
International journal of molecular medicine
Xiao J,Zhang J,Li X,Dai X,Wang J,He Y,Wei L,Shi J,Gong N
45-0042 was used in Flow cytometry/Cell sorting to demonstrate that transduction with lenti-shRNA-Blimp1 (lentiviral-mediated B-lymphocyte-induced maturation protein-1 shRNA) modulated the maturation of DCs via MHC-II molecule suppression and inhibited alloreactive T cell activation.
Fri Feb 01 00:00:00 EST 2019
Glucocorticoid Receptor-Deficient Foxp3+ Regulatory T Cells Fail to Control Experimental Inflammatory Bowel Disease.
Frontiers in immunology
Rocamora-Reverte L,Tuzlak S,von Raffay L,Tisch M,Fiegl H,Drach M,Reichardt HM,Villunger A,Tischner D,Wiegers GJ
45-0042 was used in Flow cytometry/Cell sorting to generate mice with a specific deletion of the glucocorticoid receptor (GR) in Foxp3+ Treg cells.
Thu Sep 10 00:00:00 EDT 2020
miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival.
Cell reports
Gagnon JD,Kageyama R,Shehata HM,Fassett MS,Mar DJ,Wigton EJ,Johansson K,Litterman AJ,Odorizzi P,Simeonov D,Laidlaw BJ,Panduro M,Patel S,Jeker LT,Feeney ME,McManus MT,Marson A,Matloubian M,Sanjabi S,Ansel KM
45-0042-82 was used in Flow Cytometry to show that miR-15/16 restrict T cell cycle, survival, and memory T cell differentiation.
Tue Aug 20 00:00:00 EDT 2019
Noc4L-Mediated Ribosome Biogenesis Controls Activation of Regulatory and Conventional T Cells.
Cell reports
Zhu X,Zhang W,Guo J,Zhang X,Li L,Wang T,Yan J,Zhang F,Hou B,Gao N,Gao GF,Zhou X
45-0042 was used in Flow cytometry/Cell sorting to identify the control of Treg activation and immune tolerance maintenance is due to Noc4L mediated ribosome biogenesis.
Tue Apr 23 00:00:00 EDT 2019
A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice.
Oncoimmunology
Lévesque S,Le Naour J,Pietrocola F,Paillet J,Kremer M,Castoldi F,Baracco EE,Wang Y,Vacchelli E,Stoll G,Jolly A,De La Grange P,Zitvogel L,Kroemer G,Pol JG
45-0042-82 was used in Flow Cytometry to point to the possibility of synergistic interactions among distinct classes of anticancer agents.
Sat Oct 14 00:00:00 EDT 2023
Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR.
Nature communications
Zhu H,Bhatt B,Sivaprakasam S,Cai Y,Liu S,Kodeboyina SK,Patel N,Savage NM,Sharma A,Kaufman RJ,Li H,Singh N
45-0042 was used in Flow cytometry/Cell sorting to demonstrate the promotion of plasma cell development and function by the unfolded protein response pathway is regulated by Ufbp1.
Wed Mar 06 00:00:00 EST 2019
Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis.
Cell reports
Pyaram K,Kumar A,Kim YH,Noel S,Reddy SP,Rabb H,Chang CH
45-0042 was used in Flow cytometry/Cell sorting to report that T cellspecific deletion of Keap1 results in defective development and reduced numbers of invariant natural killer T (NKT) cells in the thymus and the peripheral organs in a cell-intrinsic manner.
Tue Apr 16 00:00:00 EDT 2019
IL-17 can be protective or deleterious in murine pneumococcal pneumonia.
PLoS pathogens
Ritchie ND,Ritchie R,Bayes HK,Mitchell TJ,Evans TJ
Tue May 01 00:00:00 EDT 2018
Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b.
Nature communications
Cho S,Lee HM,Yu IS,Choi YS,Huang HY,Hashemifar SS,Lin LL,Chen MC,Afanasiev ND,Khan AA,Lin SW,Rudensky AY,Crotty S,Lu LF
45-0042 was used in Flow cytometry/Cell sorting to reveal differential cell-intrinsic regulations of GC B and Tfh cells by miR-146a and miR-146b.
Mon Jul 16 00:00:00 EDT 2018
Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis.
Nature communications
Kim DH,Park HJ,Lim S,Koo JH,Lee HG,Choi JO,Oh JH,Ha SJ,Kang MJ,Lee CM,Lee CG,Elias JA,Choi JM
45-0042 was used in Flow cytometry/Cell sorting to demonstrate that Chitinase-3-like-1 is a regulator of Th1 and CTL, which could be a potential anti-tumor immunity target.
Mon Feb 05 00:00:00 EST 2018
Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection.
Nature communications
Rolot M,Dougall AM,Chetty A,Javaux J,Chen T,Xiao X,Machiels B,Selkirk ME,Maizels RM,Hokke C,Denis O,Brombacher F,Vanderplasschen A,Gillet L,Horsnell WGC,Dewals BG
45-0042 was used in Flow cytometry/Cell sorting to study whether helminth-induced type 2 immunity functionally affects the T virtual memory cell compartment.
Tue Oct 30 00:00:00 EDT 2018
The Combination Therapy of Dietary Galacto-Oligosaccharides With Budesonide Reduces Pulmonary Th2 Driving Mediators and Mast Cell Degranulation in a Murine Model of House Dust Mite Induced Asthma.
Frontiers in immunology
Verheijden KAT,Braber S,Leusink-Muis T,Jeurink PV,Thijssen S,Kraneveld AD,Garssen J,Folkerts G,Willemsen LEM
45-0042 was used in Flow cytometry/Cell sorting to compare the efficacy of budesonide or different doses of galacto-oligosaccharides alone or with a combination therapy of budesonide and galacto-oligosaccharides on house dust mite-allergic responses in mice.
Mon Sep 30 00:00:00 EDT 2019
PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy.
Blood
Asano T,Meguri Y,Yoshioka T,Kishi Y,Iwamoto M,Nakamura M,Sando Y,Yagita H,Koreth J,Kim HT,Alyea EP,Armand P,Cutler CS,Ho VT,Antin JH,Soiffer RJ,Maeda Y,Tanimoto M,Ritz J,Matsuoka KI
45-0042 was used in Flow cytometry/Cell sorting to study the mechanisms that regulate Treg homeostasis during IL-2 therapy.
Thu Apr 13 00:00:00 EDT 2017
ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.
The Journal of experimental medicine
Schwartz C,Khan AR,Floudas A,Saunders SP,Hams E,Rodewald HR,McKenzie ANJ,Fallon PG
45-0042 was used in Flow cytometry/Cell sorting to study how group 2 innate lymphoid cells regulate adaptive Th2 cell functions.
Mon Sep 04 00:00:00 EDT 2017
A role for the histone H2A deubiquitinase MYSM1 in maintenance of CD8+ T cells.
Immunology
Förster M,Boora RK,Petrov JC,Fodil N,Albanese I,Kim J,Gros P,Nijnik A
45-0042 was used in Flow cytometry/Cell sorting to investigate the role of MYSM1 in T-cell development.
Mon May 01 00:00:00 EDT 2017
Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Goverse G,Molenaar R,Macia L,Tan J,Erkelens MN,Konijn T,Knippenberg M,Cook EC,Hanekamp D,Veldhoen M,Hartog A,Roeselers G,Mackay CR,Mebius RE
45-0042 was used in Flow cytometry/Cell sorting to study the effect of dietary fiber and short chain fatty acids on the vitamin A converting enzyme RALDH1 in intestinal epithelial cells.
Wed Mar 01 00:00:00 EST 2017
Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells.
Nature communications
Downs-Canner S,Berkey S,Delgoffe GM,Edwards RP,Curiel T,Odunsi K,Bartlett DL,Obermajer N
45-0042 was used in Flow cytometry/Cell sorting to demonstrate the tumour-associated conversion of Th17 cells to Treg cells and identify transdifferentiation-associated markers.
Tue Mar 14 00:00:00 EDT 2017
Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation.
eLife
Araujo L,Khim P,Mkhikian H,Mortales CL,Demetriou M
45-0042 was used in Flow cytometry/Cell sorting to report that aerobic glycolysis and glutaminolysis co-operatively reduce UDP-GlcNAc biosynthesis and N-glycan branching in mouse T cell blasts by starving the hexosamine pathway of glucose and glutamine.
Fri Jan 06 00:00:00 EST 2017
Protein Tyrosine Phosphatase Inhibition Prevents Experimental Cerebral Malaria by Precluding CXCR3 Expression on T Cells.
Scientific reports
Van Den Ham KM,Smith LK,Richer MJ,Olivier M
45-0042 was used in Flow cytometry/Cell sorting to demonstrate that inhibition of protein tyrosine phosphatase activity significantly attenuates T cell sequestration within the brain and prevents the development of neuropathology.
Fri Jul 14 00:00:00 EDT 2017
The efficacy of oral and subcutaneous antigen-specific immunotherapy in murine cow's milk- and peanut allergy models.
Clinical and translational allergy
Vonk MM,Wagenaar L,Pieters RHH,Knippels LMJ,Willemsen LEM,Smit JJ,van Esch BCAM,Garssen J
45-0042 was used in Flow cytometry/Cell sorting to compare oral immunotherapy and subcutaneous immunotherapy models for cows milk and peanut allergy.
Fri Apr 08 00:00:00 EDT 2022
Loss of MAPK-activated protein kinase 2 enables potent dendritic cell-driven anti-tumour T cell response.
Scientific reports
Soukup K,Halfmann A,Dillinger B,Poyer F,Martin K,Blauensteiner B,Kauer M,Kuttke M,Schabbauer G,Dohnal AM
45-0042 was used in Flow cytometry/Cell sorting to suggest that MAPK-activated protein kinase 2 deletion leads to an expansion of stimulatory CD103+ dendritic cells, mounting a potent CD8+ T cell anti-tumour response in mice.
Mon Sep 18 00:00:00 EDT 2017
IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion.
JCI insight
Le Saout C,Luckey MA,Villarino AV,Smith M,Hasley RB,Myers TG,Imamichi H,Park JH,O'Shea JJ,Lane HC,Catalfamo M
45-0042 was used in Flow cytometry/Cell sorting to propose a model in which T cells undergoing lymphopenia-induced proliferation upregulate STAT1 protein, switching on an alternate IL-7-dependent program.
Thu Nov 16 00:00:00 EST 2017
S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.
Nature immunology
Wang F,Alain T,Szretter KJ,Stephenson K,Pol JG,Atherton MJ,Hoang HD,Fonseca BD,Zakaria C,Chen L,Rangwala Z,Hesch A,Chan ESY,Tuinman C,Suthar MS,Jiang Z,Ashkar AA,Thomas G,Kozma SC,Gale M,Fitzgerald KA,Diamond MS,Mossman K,Sonenberg N,Wan Y,Lichty BD
45-0042 was used in Flow cytometry/Cell sorting to regulate cytosolic DNA-mediated activation of the transcription factor IRF3 using S6K-STING interaction.
Sun May 01 00:00:00 EDT 2016
CD8+ T cells drive autoimmune hematopoietic stem cell dysfunction and bone marrow failure.
Journal of autoimmunity
Gravano DM,Al-Kuhlani M,Davini D,Sanders PD,Manilay JO,Hoyer KK
45-0042 was used in Flow cytometry/Cell sorting to investigate whether CD8+ T cells play a non-redundant role in driving bone marrow failure.
Thu Dec 01 00:00:00 EST 2016
CD4 T Helper Cells Instruct Lymphopenia-Induced Memory-Like CD8 T Cells for Control of Acute LCMV Infection.
Frontiers in immunology
Schmitt ME,Sitte S,Voehringer D
45-0042 was used in Flow cytometry/Cell sorting to determine whether memory-like T cells can efficiently respond to foreign antigen and participate in antiviral immunity.
Wed Nov 20 00:00:00 EST 2019
Adipose tissue adaptive response to trans-10,cis-12-conjugated linoleic acid engages alternatively activated M2 macrophages.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Pini M,Touch S,Poirier H,Dalmas E,Niot I,Rouault C,Druart C,Delzenne N,Clément K,André S,Guerre-Millo M
45-0042 was used in Flow cytometry/Cell sorting to reveal a striking resilience of white adipose tissue after a short-term metabolic injury induced by t10,c12-CLA, which relies on alternatively activated M2 macrophage engagement.
Fri Jan 01 00:00:00 EST 2016
Dendritic Cells Are Dispensable for T Cell Priming and Control of Acute Lymphocytic Choriomeningitis Virus Infection.
Journal of immunology (Baltimore, Md. : 1950)
Hilpert C,Sitte S,Matthies A,Voehringer D
45-0042 was used in Flow cytometry/Cell sorting to study the role of dendritic cells as antigen presenting cells and a source of type I interferons in acute lymphocytic choriomeningitis virus infection.
Sat Oct 01 00:00:00 EDT 2016
The Use of Toll-like Receptor 4 Agonist to Reshape the Immune Signature in Ovarian Cancer.
Anticancer research
Vindevogel E,Baert T,VAN Hoylandt A,Verbist G,Vande Velde G,Garg AD,Agostinis P,Vergote I,Coosemans AN
45-0042 was used in Flow cytometry/Cell sorting to investigate whether LPS is a beneficial adjuvant in dendritic cell mono-immunotherapy of ovarian cancer.
Tue Nov 01 00:00:00 EDT 2016
Activation of the Renin-Angiotensin System Promotes Colitis Development.
Scientific reports
Shi Y,Liu T,He L,Dougherty U,Chen L,Adhikari S,Alpert L,Zhou G,Liu W,Wang J,Deb DK,Hart J,Liu SQ,Kwon J,Pekow J,Rubin DT,Zhao Q,Bissonnette M,Li YC
45-0042 was used in Flow cytometry/Cell sorting to demonstrate that the renin-angiotensin II cascade promotes colitis by stimulating intestinal epithelial cell apoptosis and mucosal TH17 responses in a blood pressure-independent manner.
Wed Jun 08 00:00:00 EDT 2016
Intravaginal Chlamydia trachomatis Challenge Infection Elicits TH1 and TH17 Immune Responses in Mice That Promote Pathogen Clearance and Genital Tract Damage.
PloS one
Vicetti Miguel RD,Quispe Calla NE,Pavelko SD,Cherpes TL
45-0042 was used in Flow cytometry/Cell sorting to determine if intravaginal infection with occulogenital Chlamydia trachomatis is a possible mouse model for Chlamydia infection in humans.
Fri Aug 04 00:00:00 EDT 2017
Cysteamine broadly improves the anti-plasmodial activity of artemisinins against murine blood stage and cerebral malaria.
Malaria journal
Moradin N,Torre S,Gauthier S,Tam M,Hawari J,Vandercruyssen K,De Spiegeleer B,Fortin A,Stevenson MM,Gros P
45-0042 was used in Flow cytometry/Cell sorting to evaluate the effect of artemisinins and cysteamine combination therapy on malarial phenotypes.
Fri May 06 00:00:00 EDT 2016
B cell-derived transforming growth factor-β1 expression limits the induction phase of autoimmune neuroinflammation.
Scientific reports
Bjarnadóttir K,Benkhoucha M,Merkler D,Weber MS,Payne NL,Bernard CCA,Molnarfi N,Lalive PH
45-0042-82 was used in Flow Cytometry to test the role for transforming growth factor-β1 expression in regulatory B cell function in autoimmune neuroinflammation.
Thu Oct 06 00:00:00 EDT 2016
CD4+ T Cells Are as Protective as CD8+ T Cells against Rickettsia typhi Infection by Activating Macrophage Bactericidal Activity.
PLoS neglected tropical diseases
Moderzynski K,Papp S,Rauch J,Heine L,Kuehl S,Richardt U,Fleischer B,Osterloh A
45-0042 was used in Flow cytometry/Cell sorting to demonstrate that CD4+ T cells are as protective as CD8+ T cells against R. typhi, provided that CD4+ TH1 effector cells are present in time to support bactericidal activity of phagocytes via the release of IFNγ and other factors.
Tue Nov 01 00:00:00 EDT 2016
Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.
Nature communications
Gomez-Rodriguez J,Meylan F,Handon R,Hayes ET,Anderson SM,Kirby MR,Siegel RM,Schwartzberg PL
45-0042 was used in Magnetic cell separation to investigate the role of IL-9 in allergic asthma and autoimmunity, showing that Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4.
Thu Mar 03 00:00:00 EST 2016
IDO1 Deficiency Does Not Affect Disease in Mouse Models of Systemic Juvenile Idiopathic Arthritis and Secondary Hemophagocytic Lymphohistiocytosis.
PloS one
Put K,Brisse E,Avau A,Imbrechts M,Mitera T,Janssens R,Proost P,Fallarino F,Wouters CH,Matthys P
45-0042 was used in Flow cytometry/Cell sorting to unravel the role of IDO1, an immune-modulatory enzyme, in the pathogenesis of certain inflammatory diseases.
Mon Aug 08 00:00:00 EDT 2016
Enhanced Immune Response in Immunodeficient Mice Improves Peripheral Nerve Regeneration Following Axotomy.
Frontiers in cellular neuroscience
Bombeiro AL,Santini JC,Thomé R,Ferreira ER,Nunes SL,Moreira BM,Bonet IJ,Sartori CR,Verinaud L,Oliveira AL
45-0042 was used in Flow cytometry/Cell sorting to investigate the contribution of lymphocytes during peripheral nerve regeneration in immunocompetent versus immunodeficient mice.
Wed Jul 06 00:00:00 EDT 2016
Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells.
Nature communications
Meininger I,Griesbach RA,Hu D,Gehring T,Seeholzer T,Bertossi A,Kranich J,Oeckinghaus A,Eitelhuber AC,Greczmiel U,Gewies A,Schmidt-Supprian M,Ruland J,Brocker T,Heissmeyer V,Heyd F,Krappmann D
45-0042 was used in Flow cytometry/Cell sorting to study how TCR-induced alternative splicing augments MALT1 scaffolding to enhance downstream signalling and to promote optimal T-cell activation.
Tue Apr 12 00:00:00 EDT 2016
Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.
Nature medicine
Wilson JE,Petrucelli AS,Chen L,Koblansky AA,Truax AD,Oyama Y,Rogers AB,Brickey WJ,Wang Y,Schneider M,Mühlbauer M,Chou WC,Barker BR,Jobin C,Allbritton NL,Ramsden DA,Davis BK,Ting JP
45-0042 was used in Flow cytometry/Cell sorting to show AIM2 regulates colon tumorigenesis by reducing activation of both DNA-PK and Akt, suggesting that Akt inhibitors could be used in treatment of certain cancers.
Sat Aug 01 00:00:00 EDT 2015
MyD88 signaling in T cells directs IgA-mediated control of the microbiota to promote health.
Cell host & microbe
Kubinak JL,Petersen C,Stephens WZ,Soto R,Bake E,O'Connell RM,Round JL
45-0042 was used in Flow cytometry/Cell sorting to show that signalling through the innate adaptor MyD88 in gut T cells coordinates germinal center responses, including T follicular helper cell and IgA+ B cell development.
Wed Feb 11 00:00:00 EST 2015
Platelets promote allergic asthma through the expression of CD154.
Cellular & molecular immunology
Tian J,Zhu T,Liu J,Guo Z,Cao X
45-0042 was used in Flow cytometry/Cell sorting to study the role and the underlying mechanism of platelets in allergic asthma, showing that platelets express CD154 which polarises Th2 responses and inhibits the generation of regulatory T-cells.
Sun Nov 01 00:00:00 EDT 2015
Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection.
The Journal of experimental medicine
Vijay R,Hua X,Meyerholz DK,Miki Y,Yamamoto K,Gelb M,Murakami M,Perlman S
45-0042 was used in Flow cytometry/Cell sorting to investigate the enhanced expression of proresolving/antiinflammatory factors in ageing, showing a critical role of phospholipase A2 group IID.
Mon Oct 19 00:00:00 EDT 2015
The MAPK-Activated Kinase MK2 Attenuates Dendritic Cell-Mediated Th1 Differentiation and Autoimmune Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Soukup K,Halfmann A,Le Bras M,Sahin E,Vittori S,Poyer F,Schuh C,Luger R,Niederreiter B,Haider T,Stoiber D,Blüml S,Schabbauer G,Kotlyarov A,Gaestel M,Felzmann T,Dohnal AM
45-0042 was used in Flow cytometry/Cell sorting to investigate the role of MK2 in dendritic cells, showing that it attenuates dendritic cell-mediated Th1 differentiation and autoimmune encephalomyelitis.
Wed Jul 15 00:00:00 EDT 2015
Gene expression profiling of the Peyer's patch mononuclear phagocyte system.
Genomics data
Bonnardel J,Da Silva C,Masse M,Montañana-Sanchis F,Gorvel JP,Lelouard H
45-0042 was used in Flow cytometry/Cell sorting to investigate the gene expression profile of the Peyer's patch mononuclear phagocyte system.
Tue Sep 01 00:00:00 EDT 2015
Near-infrared photoactivatable control of Ca(2+) signaling and optogenetic immunomodulation.
eLife
He L,Zhang Y,Ma G,Tan P,Li Z,Zang S,Wu X,Jing J,Fang S,Zhou L,Wang Y,Huang Y,Hogan PG,Han G,Zhou Y
45-0042 was used in Flow cytometry/Cell sorting to represent a step forward towards the goal of achieving remote and wireless control of Ca(2+)-modulated activities with tailored function.
Tue Dec 08 00:00:00 EST 2015
STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE.
Journal of neuroinflammation
McWilliams IL,Rajbhandari R,Nozell S,Benveniste E,Harrington LE
45-0042 was used in Flow cytometry/Cell sorting to establish the role of STAT4 in the regulation of cytokine production during experimental autoimmune encephalomyelitis pathogenesis.
Tue Jun 30 00:00:00 EDT 2015
Natural Killer Cells Mediate Protection against Yersinia pseudotuberculosis in the Mesenteric Lymph Nodes.
PloS one
Rosenheinrich M,Heine W,Schmühl CM,Pisano F,Dersch P
45-0042 was used in Flow cytometry/Cell sorting to characterise the role of natural killer cells in the response to the extracellular bacterial pathogen, yersiniae.
Tue May 10 00:00:00 EDT 2016
Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.
Nature communications
Zanvit P,Konkel JE,Jiao X,Kasagi S,Zhang D,Wu R,Chia C,Ajami NJ,Smith DP,Petrosino JF,Abbatiello B,Nakatsukasa H,Chen Q,Belkaid Y,Chen ZJ,Chen W
45-0042 was used in Flow cytometry/Cell sorting to show that the addition of antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.
Tue Sep 29 00:00:00 EDT 2015
A strategy to discover decoy chemokine ligands with an anti-inflammatory activity.
Scientific reports
Abboud D,Daubeuf F,Do QT,Utard V,Villa P,Haiech J,Bonnet D,Hibert M,Bernard P,Galzi JL,Frossard N
45-0042 was used in Flow cytometry/Cell sorting to develop a strategy to discover decoy chemokine ligands with an anti-inflammatory activity.
Wed Oct 07 00:00:00 EDT 2015
Anthocyanin Extracted from Black Soybean Seed Coats Prevents Autoimmune Arthritis by Suppressing the Development of Th17 Cells and Synthesis of Proinflammatory Cytokines by Such Cells, via Inhibition of NF-κB.
PloS one
Min HK,Kim SM,Baek SY,Woo JW,Park JS,Cho ML,Lee J,Kwok SK,Kim SW,Park SH
45-0042 was used in Flow cytometry/Cell sorting to investigate the anti-arthritic effects of anthocyanin extracted from black soybean seed coats in both murine and human cells.
Tue Jun 14 00:00:00 EDT 2016
CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation.
The Journal of experimental medicine
Kennedy JM,Fodil N,Torre S,Bongfen SE,Olivier JF,Leung V,Langlais D,Meunier C,Berghout J,Langat P,Schwartzentruber J,Majewski J,Lathrop M,Vidal SM,Gros P
45-0042 was used in Flow cytometry/Cell sorting to suggest that CCDC88B is the morbid gene underlying the pleiotropic effect of the 11q13 locus on inflammation.
Mon Dec 15 00:00:00 EST 2014
IL-17-producing NKT cells depend exclusively on IL-7 for homeostasis and survival.
Mucosal immunology
Webster KE,Kim HO,Kyparissoudis K,Corpuz TM,Pinget GV,Uldrich AP,Brink R,Belz GT,Cho JH,Godfrey DI,Sprent J
45-0042 was used in Flow cytometry/Cell sorting to elucidate the factors that maintain the natural killer T cell population in the periphery.
Mon Sep 01 00:00:00 EDT 2014
Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium.
Mucosal immunology
Wang Z,Friedrich C,Hagemann SC,Korte WH,Goharani N,Cording S,Eberl G,Sparwasser T,Lochner M
45-0042 was used in Flow cytometry/Cell sorting to study the impact of Foxp3(+) Tregs on inflammatory processes elicited by the bacterial pathogen C. rodentium, showing that Tregs promote a protective Th17-associated immune response.
Sat Nov 01 00:00:00 EDT 2014
Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis.
PLoS pathogens
Le Saout C,Hasley RB,Imamichi H,Tcheung L,Hu Z,Luckey MA,Park JH,Durum SK,Smith M,Rupert AW,Sneller MC,Lane HC,Catalfamo M
45-0042 was used in Flow cytometry/Cell sorting to define the mechanisms behind immune cell maintenance in HIV infected individuals.
Sat Mar 01 00:00:00 EST 2014
Differential requirement for CCR4 and CCR7 during the development of innate and adaptive αβT cells in the adult thymus.
Journal of immunology (Baltimore, Md. : 1950)
Cowan JE,McCarthy NI,Parnell SM,White AJ,Bacon A,Serge A,Irla M,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G
45-0042 was used in Flow cytometry/Cell sorting to identify novel roles for CCR7 during intrathymic T cell development, highlighting its importance in enabling multiple αβT cell lineages to access the thymic medulla.
Fri Aug 01 00:00:00 EDT 2014
Regulatory T cells shape the resident memory T cell response to virus infection in the tissues.
Journal of immunology (Baltimore, Md. : 1950)
Graham JB,Da Costa A,Lund JM
45-0042 was used in Flow cytometry/Cell sorting to demonstrate that Treg-dependent production of TGF-β results in increased expression of CD103 on CD8(+) T cells.
Wed Jan 15 00:00:00 EST 2014
Chronic ethanol diet increases regulatory T-cell activity and inhibits hepatitis C virus core-specific cellular immune responses in mice.
Hepatology research : the official journal of the Japan Society of Hepatology
Ortiz V,Wands JR
45-0042 was used in Flow cytometry/Cell sorting to investigate the immune response to chronic ethanol consumption and associated hepatitis C viral infection.
Tue Jul 01 00:00:00 EDT 2014
Prevention or early cure of type 1 diabetes by intranasal administration of gliadin in NOD mice.
PloS one
Funda DP,Fundova P,Hansen AK,Buschard K
45-0042 was used in Flow cytometry/Cell sorting to investigate whether intranasal (i.n.) administration of gliadin or gluten may arrest the diabetogenic process, showing that i.n. administration of gliadin prevents type 1 diabetes in NOD mice.
Tue Jan 13 00:00:00 EST 2015
P2X7 receptor modulates inflammatory and functional pulmonary changes induced by silica.
PloS one
Monção-Ribeiro LC,Faffe DS,Santana PT,Vieira FS,da Graça CL,Marques-da-Silva C,Machado MN,Caruso-Neves C,Zin WA,Borojevic R,Takiya CM,Coutinho-Silva R
45-0042 was used in Flow cytometry/Cell sorting to investigate the role of P2X7 in a murine model of silicosis, showing that P2X7 KO mice had reduced lung pathology compared to WT mice, and that P2X7 participates in silica phagocytosis, IL-1β secretion, ROS and NO production.
Thu Sep 17 00:00:00 EDT 2015
A new recombinant BCG vaccine induces specific Th17 and Th1 effector cells with higher protective efficacy against tuberculosis.
PloS one
da Costa AC,Costa-Júnior Ade O,de Oliveira FM,Nogueira SV,Rosa JD,Resende DP,Kipnis A,Junqueira-Kipnis AP
45-0042 was used in Flow cytometry/Cell sorting to evaluate the immunogenicity and protection of a new BCG vaccine against TB, showing that it induces specific Th17 and Th1 effector cells with higher protective efficacy.
Fri Dec 18 00:00:00 EST 2015
Measurement of CD8 and CD4 T Cell Responses in Mouse Lungs.
Bio-protocol
Fett C,Zhao J,Perlman S
45-0042 was used in Flow cytometry/Cell sorting to study the methods used to characterise the CD8 & CD4 T cell responses after a viral challenge in the lung.
Thu Feb 10 00:00:00 EST 2022
Type 2 innate lymphoid cells control eosinophil homeostasis.
Nature
Nussbaum JC,Van Dyken SJ,von Moltke J,Cheng LE,Mohapatra A,Molofsky AB,Thornton EE,Krummel MF,Chawla A,Liang HE,Locksley RM
45-0042 was used in Flow cytometry/Cell sorting to investigate the processes underlying regulation of cytokine and chemokines for eosinophil development and survival, showing that type 2 innate lymphoid cells control eosinophil homeostasis.
Thu Oct 10 00:00:00 EDT 2013
Ecto-5'-nucleotidase on immune cells protects from adverse cardiac remodeling.
Circulation research
Bönner F,Borg N,Jacoby C,Temme S,Ding Z,Flögel U,Schrader J
45-0042 was used in Flow cytometry/Cell sorting to examine the role of CD73 in cardiac repair and remodelling in mice after reperfused myocardial infarction.
Fri Jul 19 00:00:00 EDT 2013
The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development.
The Journal of experimental medicine
Cowan JE,Parnell SM,Nakamura K,Caamano JH,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G
45-0042 was used in Flow cytometry/Cell sorting to demonstrate a differential requirement for the thymic medulla in relation to CD4 conventional and Foxp3(+) thymocyte lineages.
Mon Apr 08 00:00:00 EDT 2013
MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies.
The Journal of experimental medicine
Molnarfi N,Schulze-Topphoff U,Weber MS,Patarroyo JC,Prod'homme T,Varrin-Doyer M,Shetty A,Linington C,Slavin AJ,Hidalgo J,Jenne DE,Wekerle H,Sobel RA,Bernard CC,Shlomchik MJ,Zamvil SS
45-0042 was used in Flow cytometry/Cell sorting to investigate the contribution of B cells to antigen presentation and pathogenic T cell activation in the multiple sclerosis model experimental autoimmune encephalomyelitis.
Mon Dec 16 00:00:00 EST 2013
Therapeutic evaluation of ex vivo-generated versus natural regulatory T-cells in a mouse model of chronic gut inflammation.
Inflammatory bowel diseases
Karlsson F,Martinez NE,Gray L,Zhang S,Tsunoda I,Grisham MB
45-0042 was used in Flow cytometry/Cell sorting to study the effect of ex vivo-generated and isolated Treg cells on a mouse model of chronic colitis, showing that ex-vivo Tregs were more potent at attenuating colitis, likely due to the associated decrease in IL-6 and IL-17A expression in the colon.
Tue Oct 01 00:00:00 EDT 2013
Generation of both cortical and Aire(+) medullary thymic epithelial compartments from CD205(+) progenitors.
European journal of immunology
Baik S,Jenkinson EJ,Lane PJ,Anderson G,Jenkinson WE
45-0042 was used in Flow cytometry/Cell sorting to reveal an unexpected overlap in the phenotypic properties of bipotent TECs with their lineage-restricted counterparts.
Fri Mar 01 00:00:00 EST 2013
Tracking antigen-specific CD4+ T cells throughout the course of chronic Leishmania major infection in resistant mice.
European journal of immunology
Pagán AJ,Peters NC,Debrabant A,Ribeiro-Gomes F,Pepper M,Karp CL,Jenkins MK,Sacks DL
45-0042 was used in Flow cytometry/Cell sorting to study parasite-specific primary CD4(+) T-cell responses to L. major in mice resistant to infection.
Fri Feb 01 00:00:00 EST 2013
11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Kipari T,Hadoke PW,Iqbal J,Man TY,Miller E,Coutinho AE,Zhang Z,Sullivan KM,Mitic T,Livingstone DE,Schrecker C,Samuel K,White CI,Bouhlel MA,Chinetti-Gbaguidi G,Staels B,Andrew R,Walker BR,Savill JS,Chapman KE,Seckl JR
45-0042 was used in Flow cytometry/Cell sorting to determine the effects of 11Β-Hydroxysteroid dehydrogenase type-1 deficiency on atherosclerosis and its inflammation.
Mon Apr 01 00:00:00 EDT 2013
Sialoadhesin deficiency does not influence the severity of lupus nephritis in New Zealand black x New Zealand white F1 mice.
Arthritis research & therapy
Kidder D,Richards HE,Lyons PA,Crocker PR
45-0042 was used in Flow cytometry/Cell sorting to investigate a potential causative role of Sialoadhesin in lupus.
Fri Nov 01 00:00:00 EDT 2013
Adoptive transfer of regulatory T cells protects against Coxsackievirus B3-induced cardiac fibrosis.
PloS one
Cao Y,Xu W,Xiong S
45-0042 was used in Flow cytometry/Cell sorting to investigate the role of Tregs in the development of viral myocarditis-caused cardiac fibrosis.
Tue Apr 08 00:00:00 EDT 2014
Mast cells contribute to double-stranded RNA-induced augmentation of airway eosinophilia in a murine model of asthma.
Respiratory research
Kan-o K,Matsunaga Y,Fukuyama S,Moriwaki A,Hirai-Kitajima H,Yokomizo T,Aritake K,Urade Y,Nakanishi Y,Inoue H,Matsumoto K
45-0042 was used in Flow cytometry/Cell sorting to determine the role of mast cells in the virus-associated pathogenesis of asthma.
Mon Mar 04 00:00:00 EST 2013
Chlamydia pneumoniae infection in mice induces chronic lung inflammation, iBALT formation, and fibrosis.
PloS one
Jupelli M,Shimada K,Chiba N,Slepenkin A,Alsabeh R,Jones HD,Peterson E,Chen S,Arditi M,Crother TR
45-0042 was used in Flow cytometry/Cell sorting to investigate how chlamydia pneumoniae infection in mice induces chronic lung inflammation, iBALT formation, and fibrosis..
Sat Aug 02 00:00:00 EDT 2014
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.
Immunity
Hall AO,Beiting DP,Tato C,John B,Oldenhove G,Lombana CG,Pritchard GH,Silver JS,Bouladoux N,Stumhofer JS,Harris TH,Grainger J,Wojno ED,Wagage S,Roos DS,Scott P,Turka LA,Cherry S,Reiner SL,Cua D,Belkaid Y,Elloso MM,Hunter CA
45-0042 was used in Flow cytometry/Cell sorting to study the promotion of distinct Treg cell populations by the cytokines IL-27 and IFN-y, and the role they play in limiting infection induced pathology.
Fri Sep 21 00:00:00 EDT 2012
Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells.
The Journal of experimental medicine
Cherrier M,Sawa S,Eberl G
45-0042 was used in Flow cytometry/Cell sorting to investigate the development of lymphoid tissue inducer (LTi) cells from common lymphoid progenitors (CLPs) in the fetal liver, showing that sequential changes in expression of Notch, Id2, and RORγt orchestrate the development of LTi cells.
Mon Apr 09 00:00:00 EDT 2012
Definition of IFN-γ-related pathways critical for chemically-induced systemic autoimmunity.
Journal of autoimmunity
Pollard KM,Hultman P,Toomey CB,Cauvi DM,Hoffman HM,Hamel JC,Kono DH
45-0042 was used in Flow cytometry/Cell sorting to demonstrate that there is substantial redundancy in genes that regulate IFN-γ expression in contrast to those mediating later signaling events.
Sat Dec 01 00:00:00 EST 2012
Fates of CD4+ T cells in a tolerant environment depend on timing and place of antigen exposure.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Burrell BE,Bromberg JS
45-0042 was used in Flow cytometry/Cell sorting to elucidate the key factors that determine the fate of graft reactive T cells.
Thu Mar 01 00:00:00 EST 2012
T cell apoptosis and induction of Foxp3+ regulatory T cells underlie the therapeutic efficacy of CD4 blockade in experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Duarte J,Carrié N,Oliveira VG,Almeida C,Agua-Doce A,Rodrigues L,Simas JP,Mars LT,Graca L
45-0042 was used in Flow cytometry/Cell sorting to investigate the mechanism underlying effective MS prevention, showing that apoptosis of T cells and induction of Foxp3+ Tregs underlie efficacy of CD4 blockade in EAE.
Wed Aug 15 00:00:00 EDT 2012
Rapid in vivo conversion of effector T cells into Th2 cells during helminth infection.
Journal of immunology (Baltimore, Md. : 1950)
Panzer M,Sitte S,Wirth S,Drexler I,Sparwasser T,Voehringer D
45-0042 was used in Flow cytometry/Cell sorting to determine whether different classes of T cells can be converted into IL-4-expressing Th2 cells in vivo by infection of mice with gastrointestinal helminth.
Sun Jan 15 00:00:00 EST 2012
CD28 promotes CD4+ T cell clonal expansion during infection independently of its YMNM and PYAP motifs.
Journal of immunology (Baltimore, Md. : 1950)
Pagán AJ,Pepper M,Chu HH,Green JM,Jenkins MK
45-0042 was used in Flow cytometry/Cell sorting to track polyclonal peptide:MHCII-specific CD4+ T cells in vivo, in mice with mutations in two sites within the cytoplasmic tail of CD28.
Sat Sep 15 00:00:00 EDT 2012
Resident cardiac immune cells and expression of the ectonucleotidase enzymes CD39 and CD73 after ischemic injury.
PloS one
Bönner F,Borg N,Burghoff S,Schrader J
45-0042 was used in Flow cytometry/Cell sorting to explore the abundance of CD73 and CD39 on immune cells under control conditions and in response to inflammation.
Thu Aug 30 00:00:00 EDT 2012
TNF optimally activatives regulatory T cells by inducing TNF receptor superfamily members TNFR2, 4-1BB and OX40.
European journal of immunology
Hamano R,Huang J,Yoshimura T,Oppenheim JJ,Chen X
45-0042 was used in Flow cytometry/Cell sorting to investigate pleiotropy in TNF inflammatory effects, showing that it activates Tregs by inducing TNFR2, 4-1BB and OX40.
Fri Jul 01 00:00:00 EDT 2011
Eosinophils contribute to IL-4 production and shape the T-helper cytokine profile and inflammatory response in pulmonary cryptococcosis.
The American journal of pathology
Piehler D,Stenzel W,Grahnert A,Held J,Richter L,Köhler G,Richter T,Eschke M,Alber G,Müller U
45-0042 was used in Flow cytometry/Cell sorting to investigate the time course of IL-4 production and its innate cellular source in mice infected intranasally with Cryptococcus neoformans.
Mon Aug 01 00:00:00 EDT 2011
Autoreactive Tbet-positive CD4 T cells develop independent of classic Th1 cytokine signaling during experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Yeh WI,McWilliams IL,Harrington LE
45-0042 was used in Flow cytometry/Cell sorting to study changes in expression of Tbet by CD4 T cells from distinct areas of the body following the onset of experimental autoimmune encephalomyelitis.
Tue Nov 15 00:00:00 EST 2011
Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression.
PloS one
Serre K,Bénézech C,Desanti G,Bobat S,Toellner KM,Bird R,Chan S,Kastner P,Cunningham AF,Maclennan IC,Mohr E
45-0042 was used in Flow cytometry/Cell sorting to reveal the selective upregulation of Helios during Th2 and TFh responses to alum-protein vaccines.
Mon Oct 17 00:00:00 EDT 2011
Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths.
Immunity
Ohnmacht C,Schwartz C,Panzer M,Schiedewitz I,Naumann R,Voehringer D
45-0042 was used in Flow cytometry/Cell sorting to demonstrate that basophils play an important role for protective immunity against helminths and orchestrate chronic allergic inflammation.
Fri Sep 24 00:00:00 EDT 2010
Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2.
Blood
Huber S,Hoffmann R,Muskens F,Voehringer D
45-0042 was used in Flow cytometry/Cell sorting to study how IL-4 induced the expression of PD-L2 on CAM, and LPS increased the expression of PD-L1 on alternatively activated macrophages.
Thu Oct 28 00:00:00 EDT 2010
The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Pastorino S,Renganathan H,Caliva MJ,Filbert EL,Opoku-Ansah J,Sulzmaier FJ,Gawecka JE,Werlen G,Shaw AS,Ramos JW
45-0042 was used in Flow cytometry/Cell sorting to investigate the physiological function of PEA-15, showing that it negatively regulates T-cell receptor signalling.
Sun Aug 01 00:00:00 EDT 2010
Visualization and phenotyping of proinflammatory antigen-specific T cells during collagen-induced arthritis in a mouse with a fixed collagen type II-specific transgenic T-cell receptor β-chain.
Arthritis research & therapy
Merky P,Batsalova T,Bockermann R,Dzhambazov B,Sehnert B,Burkhardt H,Bäcklund J
45-0042 was used in Flow cytometry/Cell sorting to establish a system which enables the detection and phenotyping of T cells specific for the galactosylated CII peptide.
Wed Jan 19 00:00:00 EST 2011
Heterogeneity among viral antigen-specific CD4+ T cells and their de novo recruitment during persistent polyomavirus infection.
Journal of immunology (Baltimore, Md. : 1950)
Lin E,Kemball CC,Hadley A,Wilson JJ,Hofstetter AR,Pack CD,Lukacher AE
45-0042 was used in Flow cytometry/Cell sorting to investigate the heterogeneity in the viral antigen-specific CD4+ T cell responses to chronic polyomavirus infection.
Sun Aug 01 00:00:00 EDT 2010
Differential geminin requirement for proliferation of thymocytes and mature T cells.
Journal of immunology (Baltimore, Md. : 1950)
Karamitros D,Kotantaki P,Lygerou Z,Veiga-Fernandes H,Pachnis V,Kioussis D,Taraviras S
45-0042 was used in Flow cytometry/Cell sorting to gain insight into the in vivo role of Geminin in progenitor cell division and differentiation.
Mon Mar 01 00:00:00 EST 2010
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells.
The Journal of experimental medicine
Francisco LM,Salinas VH,Brown KE,Vanguri VK,Freeman GJ,Kuchroo VK,Sharpe AH
45-0042 was used in Flow cytometry/Cell sorting to investigate the role of PD-L1 in the development and function of regulatory T cells for peripheral tolerance.
Mon Dec 21 00:00:00 EST 2009
Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses.
Journal of immunology (Baltimore, Md. : 1950)
Sahu N,Venegas AM,Jankovic D,Mitzner W,Gomez-Rodriguez J,Cannons JL,Sommers C,Love P,Sher A,Schwartzberg PL,August A
45-0042 was used in Flow cytometry/Cell sorting to determine that Itk and Txk exert their effects on Th cell differentiation/function at the level of expression.
Sat Nov 01 00:00:00 EDT 2008
IL-10 regulates movement of intestinally derived CD4+ T cells to the liver.
Journal of immunology (Baltimore, Md. : 1950)
Bliss SK,Bliss SP,Beiting DP,Alcaraz A,Appleton JA
Fri Jun 15 00:00:00 EDT 2007
Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}.
Proceedings of the National Academy of Sciences of the United States of America
Rubinstein MP,Kovar M,Purton JF,Cho JH,Boyman O,Surh CD,Sprent J
Tue Jun 13 00:00:00 EDT 2006
