Product References
Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity.
Cell
Overacre-Delgoffe AE,Chikina M,Dadey RE,Yano H,Brunazzi EA,Shayan G,Horne W,Moskovitz JM,Kolls JK,Sander C,Shuai Y,Normolle DP,Kirkwood JM,Ferris RL,Delgoffe GM,Bruno TC,Workman CJ,Vignali DAA
14-0083 was used in Flow cytometry/Cell sorting to identify the basis for Nrp1 dependency and the key drivers of Treg fragility to improve immunotherapy for human cancer.
Thu Jun 01 00:00:00 EDT 2017
Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer.
Gut
Zhang Y,Velez-Delgado A,Mathew E,Li D,Mendez FM,Flannagan K,Rhim AD,Simeone DM,Beatty GL,Pasca di Magliano M
14008382 was used in immunohistochemistry to discuss the role of myeloid cells in pancreatic cancer pathogenesis
Sun Jan 01 00:00:00 EST 2017
An Antigen-Presenting and Apoptosis-Inducing Polymer Microparticle Prolongs Alloskin Graft Survival by Selectively and Markedly Depleting Alloreactive CD8+ T Cells.
Frontiers in immunology
Wang W,Shahzad KA,Li M,Zhang A,Zhang L,Xu T,Wan X,Shen C
14-0083 was used in Immunohistochemistry to document the high potential of PLGA MP-based KaAPCs as a novel antigen-specific immunotherapy for allograft rejection and autoimmune disorder.
Wed Nov 20 00:00:00 EST 2019
Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice.
Neurobiology of disease
MacPherson KP,Sompol P,Kannarkat GT,Chang J,Sniffen L,Wildner ME,Norris CM,Tansey MG
Published figure using CD8b monoclonal antibody (Product # 14-0083-82) in Flow Cytometry
Thu Jun 01 00:00:00 EDT 2017
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.
Nature communications
Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP
Published figure using CD8b monoclonal antibody (Product # 14-0083-82) in Flow Cytometry
Mon Feb 13 00:00:00 EST 2017
A human programmed death-ligand 1-expressing mouse tumor model for evaluating the therapeutic efficacy of anti-human PD-L1 antibodies.
Scientific reports
Huang A,Peng D,Guo H,Ben Y,Zuo X,Wu F,Yang X,Teng F,Li Z,Qian X,Qin FX
14008382 was used in flow cytometry to study a mouse model of anti-human PD-L1 for developing new cancer treatments.
Thu Feb 16 00:00:00 EST 2017
Successful Immunotherapy against a Transplantable Mouse Squamous Lung Carcinoma with Anti-PD-1 and Anti-CD137 Monoclonal Antibodies.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
Azpilikueta A,Agorreta J,Labiano S,Pérez-Gracia JL,Sánchez-Paulete AR,Aznar MA,Ajona D,Gil-Bazo I,Larrayoz M,Teijeira A,Rodriguez-Ruiz ME,Pio R,Montuenga LM,Melero I
14008382 was used in blocking or activating experiment to discuss models of squamous lung tumors to test therapeutic regimens
Fri Apr 01 00:00:00 EDT 2016
Intravaginal Chlamydia trachomatis Challenge Infection Elicits TH1 and TH17 Immune Responses in Mice That Promote Pathogen Clearance and Genital Tract Damage.
PloS one
Vicetti Miguel RD,Quispe Calla NE,Pavelko SD,Cherpes TL
14-0083 was used in Flow cytometry/Cell sorting to determine if intravaginal infection with occulogenital Chlamydia trachomatis is a possible mouse model for Chlamydia infection in humans.
Fri Aug 04 00:00:00 EDT 2017
High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner.
Scientific reports
Polansky JK,Bahri R,Divivier M,Duitman EH,Vock C,Goyeneche-Patino DA,Orinska Z,Bulfone-Paus S
14-0083 was used in Flow cytometry/Cell sorting to analyse the in vivo potential of IL15 as an immune-regulator when available at different concentrations or delivery modes.
Fri Jan 29 00:00:00 EST 2016
CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation.
Nature communications
Cao W,Guo J,Wen X,Miao L,Lin F,Xu G,Ma R,Yin S,Hui Z,Chen T,Guo S,Chen W,Huang Y,Liu Y,Wang J,Wei L,Wang L
14-0083 was used in Flow cytometry/Cell sorting to investigate whether the CpG-binding protein Cxxc1 plays a role in thymocyte development.
Mon May 23 00:00:00 EDT 2016
Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition.
The Journal of clinical investigation
Bhadra R,Moretto MM,Castillo JC,Petrovas C,Ferrando-Martinez S,Shokal U,Leal M,Koup RA,Eleftherianos I,Khan IA
14-0083 was used in Flow cytometry/Cell sorting to investigate the progressive loss of CD8+ T cell polyfunctionality during aging, using animals challenged with the obligate intracellular pathogen Encephalitozoon cuniculi.
Sun Jun 01 00:00:00 EDT 2014
Soluble CD83 ameliorates experimental colitis in mice.
Mucosal immunology
Eckhardt J,Kreiser S,Döbbeler M,Nicolette C,DeBenedette MA,Tcherepanova IY,Ostalecki C,Pommer AJ,Becker C,Günther C,Zinser E,Mak TW,Steinkasserer A,Lechmann M
14-0083 was used in Immunohistochemistry to investigate new strategies for treatment of IBD, showing that soluble CD83 ameliorates experimental colitis in mice.
Tue Jul 01 00:00:00 EDT 2014
Intraepithelial T-cell cytotoxicity, induced bronchus-associated lymphoid tissue, and proliferation of pneumocytes in experimental mouse models of influenza.
Viral immunology
Sell S,Guest I,McKinstry KK,Strutt TM,Kohlmeier JE,Brincks E,Tighe M,Blackman MA,Woodland DL,Dutton RW,Swain SL
14-0083 was used in Immunohistochemistry to examine the lungs of mice with experimental influenza virus.
Mon Dec 01 00:00:00 EST 2014
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.
Nature communications
Chen L,Gibbons DL,Goswami S,Cortez MA,Ahn YH,Byers LA,Zhang X,Yi X,Dwyer D,Lin W,Diao L,Wang J,Roybal J,Patel M,Ungewiss C,Peng D,Antonia S,Mediavilla-Varela M,Robertson G,Suraokar M,Welsh JW,Erez B,Wistuba II,Chen L,Peng D,Wang S,Ullrich SE,Heymach JV,Kurie JM,Qin FX
Published figure using CD8b monoclonal antibody (Product # 14-0083-82) in Flow Cytometry
Tue Oct 28 00:00:00 EDT 2014
Constitutively CD40-activated B cells regulate CD8 T cell inflammatory response by IL-10 induction.
Journal of immunology (Baltimore, Md. : 1950)
Koni PA,Bolduc A,Takezaki M,Ametani Y,Huang L,Lee JR,Nutt SL,Kamanaka M,Flavell RA,Mellor AL,Tsubata T,Shimoda M
14-0083 was used in Flow cytometry/Cell sorting to investigate the role of constitutively CD40-activated B cells in the CD8 T cell inflammatory response.
Mon Apr 01 00:00:00 EDT 2013
Donor CD8+ T cells prevent Toxoplasma gondii de-encystation but fail to rescue the exhausted endogenous CD8+ T cell population.
Infection and immunity
Bhadra R,Cobb DA,Khan IA
14-0083 was used in Flow cytometry/Cell sorting to determine if treatment with exogenous CD8+ T cells can rescue the endogenous population during Toxoplasma gondii infection.
Sun Sep 01 00:00:00 EDT 2013
Deletion of Snai2 and Snai3 results in impaired physical development compounded by lymphocyte deficiency.
PloS one
Pioli PD,Dahlem TJ,Weis JJ,Weis JH
Published figure using CD8b monoclonal antibody (Product # 14-0083-82) in Flow Cytometry
Wed Feb 19 00:00:00 EST 2014
Immune response is an important aspect of the antitumor effect produced by a CD40L-encoding oncolytic adenovirus.
Cancer research
Diaconu I,Cerullo V,Hirvinen ML,Escutenaire S,Ugolini M,Pesonen SK,Bramante S,Parviainen S,Kanerva A,Loskog AS,Eliopoulos AG,Pesonen S,Hemminki A
14-0083 was used in Immunohistochemistry to test whether a transcriptionally targeted oncolytic adenovirus, which features a capsid modification and is armed with CD40L, can result in oncolytic antitumor activity and stimulate an immune response.
Tue May 01 00:00:00 EDT 2012
NK cells are required for costimulatory blockade induced tolerance to vascularized allografts.
Transplantation
van der Touw W,Burrell B,Lal G,Bromberg JS
14-0083 was used in Immunohistochemistry on frozen tissues to investigate the role of NK cells in allograft tolerance, showing that they are required for costimulatory blockade induced tolerance to vascularised allografts.
Thu Sep 27 00:00:00 EDT 2012
NK1.1 cells and CD8 T cells mediate the antitumor activity of Cl-IB-MECA in a mouse melanoma model.
Neoplasia (New York, N.Y.)
Morello S,Sorrentino R,Montinaro A,Luciano A,Maiolino P,Ngkelo A,Arra C,Adcock IM,Pinto A
14-0083 was used in Flow cytometry/Cell sorting to provide novel insights into the mechanism by which Cl-IB-MECA leads to an effective antitumour response, reaffirming its therapeutic potential.
Fri Apr 01 00:00:00 EDT 2011
Influence of enriched environment on viral encephalitis outcomes: behavioral and neuropathological changes in albino Swiss mice.
PloS one
de Sousa AA,Reis R,Bento-Torres J,Trévia N,Lins NA,Passos A,Santos Z,Diniz JA,Vasconcelos PF,Cunningham C,Perry VH,Diniz CW
14-0083 was used in Immunohistochemistry to suggest that an enriched environment promotes a more effective immune response to clear CNS virus and not at the cost of CNS damage.
Tue Jan 11 00:00:00 EST 2011
Notch dimerization is required for leukemogenesis and T-cell development.
Genes & development
Liu H,Chi AW,Arnett KL,Chiang MY,Xu L,Shestova O,Wang H,Li YM,Bhandoola A,Aster JC,Blacklow SC,Pear WS
14-0083 was used in Flow cytometry/Cell sorting to show that dimeric Notch transcriptional complexes are required for T-cell maturation and leukemic transformation but are dispensable for T-cell fate specification from a multipotential precursor.
Mon Nov 01 00:00:00 EDT 2010
Essential role for IL-27 receptor signaling in prevention of Th1-mediated immunopathology during malaria infection.
Journal of immunology (Baltimore, Md. : 1950)
Findlay EG,Greig R,Stumhofer JS,Hafalla JC,de Souza JB,Saris CJ,Hunter CA,Riley EM,Couper KN
14-0083 was used in Flow cytometry/Cell sorting to demonstrate the essential role of IL-27R signalling in regulating effector T cell function during malaria infection.
Sun Aug 15 00:00:00 EDT 2010
Expression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine.
Gastroenterology
Shang L,Thirunarayanan N,Viejo-Borbolla A,Martin AP,Bogunovic M,Marchesi F,Unkeless JC,Ho Y,Furtado GC,Alcami A,Merad M,Mayer L,Lira SA
Published figure using CD8b monoclonal antibody (Product # 14-0083-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2009
STAT6 deletion converts the Th2 inflammatory pathology afflicting Lat(Y136F) mice into a lymphoproliferative disorder involving Th1 and CD8 effector T cells.
Journal of immunology (Baltimore, Md. : 1950)
Archambaud C,Sansoni A,Mingueneau M,Devilard E,Delsol G,Malissen B,Malissen M
14-0083 was used in Flow cytometry/Cell sorting to study the effect of STAT6 delection on Lat(Y136F) mice.
Sun Mar 01 00:00:00 EST 2009
CD8alphaalpha T cells in lesions of Listeria monocytogenes-infected beta2m-deficient mice.
Microbial pathogenesis
Thoma-Uszynski S,Emoto M,Kaufmann SH
Fri Aug 01 00:00:00 EDT 1997
Depletion of T-cell subpopulations results in exacerbation of myocarditis and parasitism in experimental Chagas' disease.
Infection and immunity
Tarleton RL,Sun J,Zhang L,Postan M
Sun May 01 00:00:00 EDT 1994
