Product References
HSF1 promotes CD69+ Treg differentiation to inhibit colitis progression.
Theranostics
Yu L,Zhou B,Zhu Y,Li L,Zhong Y,Zhu L,Wang H,Chen H,Xu J,Guo T,Feng L,Wang X,Cai Z,Wang J,Jin H
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Tue Apr 18 00:00:00 EDT 2023
Novel Bruton's tyrosine kinase inhibitor TAS5315 suppresses the progression of inflammation and joint destruction in rodent collagen-induced arthritis.
PloS one
Akasaka D,Iguchi S,Kaneko R,Yoshiga Y,Kajiwara D,Nakachi Y,Noma N,Tanaka K,Shimizu A,Hosoi F
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Mon Feb 27 00:00:00 EST 2023
Intranasal Immunization With a c-di-GMP-Adjuvanted Acellular Pertussis Vaccine Provides Superior Immunity Against Bordetella pertussis in a Mouse Model.
Frontiers in immunology
Jiang W,Wang X,Su Y,Cai L,Li J,Liang J,Gu Q,Sun M,Shi L
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Tue May 03 00:00:00 EDT 2022
Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain.
eLife
Kovacs MA,Cowan MN,Babcock IW,Sibley LA,Still K,Batista SJ,Labuzan SA,Sethi I,Harris TH
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Wed Dec 21 00:00:00 EST 2022
An autonomous TCR signal-sensing switch influences CD4/CD8 lineage choice in mice.
Communications biology
Basu J,Zha J,Nicolas E,Coulton M,Czyzewicz P,Hua X,Ge L,Kappes DJ
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Fri Jan 21 00:00:00 EST 2022
CP-25 exerts a protective effect against ConA-induced hepatitis via regulating inflammation and immune response.
Frontiers in pharmacology
Li N,Wu JJ,Qi M,Wang ZY,Zhang SN,Li XQ,Chen TT,Wang MF,Zhang LL,Wei W,Sun WY
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Sat Dec 03 00:00:00 EST 2022
A novel costimulatory molecule gene-modified leukemia cell-derived exosome-targeted CD4+ T cell vaccine efficiently enhances anti-leukemia immunity.
Frontiers in immunology
Li J,Huang F,Jiang Y,Zhao J,Wan J,Hao S
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Tue Dec 06 00:00:00 EST 2022
Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors.
Nature communications
Darragh LB,Gadwa J,Pham TT,Van Court B,Neupert B,Olimpo NA,Nguyen K,Nguyen D,Knitz MW,Hoen M,Corbo S,Joshi M,Zhuang Y,Amann M,Wang XJ,Dow S,Kedl RM,Samedi V,Boss MK,Karam SD
14-0691-82 was used in Flow cytometry/Cell sorting to support using lymphatic sparing radiation therapy for head and neck cancer.
Wed Nov 16 00:00:00 EST 2022
ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation.
Cellular & molecular immunology
Liu Y,Bockermann R,Hadi M,Safari I,Carrion B,Kveiborg M,Issazadeh-Navikas S
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Sun Aug 01 00:00:00 EDT 2021
Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells.
The Journal of experimental medicine
Sasai M,Ma JS,Okamoto M,Nishino K,Nagaoka H,Takashima E,Pradipta A,Lee Y,Kosako H,Suh PG,Yamamoto M
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Mon Jul 05 00:00:00 EDT 2021
Fasudil prevents liver fibrosis via activating natural killer cells and suppressing hepatic stellate cells.
World journal of gastroenterology
Han QJ,Mu YL,Zhao HJ,Zhao RR,Guo QJ,Su YH,Zhang J
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Mon Jun 28 00:00:00 EDT 2021
TRPM8 channel augments T-cell activation and proliferation.
Cell biology international
Acharya TK,Tiwari A,Majhi RK,Goswami C
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy.
Journal of hematology & oncology
Kim HR,Park JS,Park JH,Yasmin F,Kim CH,Oh SK,Chung IJ,Jun CD
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Wed Mar 17 00:00:00 EDT 2021
Suppression of mucosal Th17 memory responses by acellular pertussis vaccines enhances nasal Bordetella pertussis carriage.
NPJ vaccines
Dubois V,Chatagnon J,Thiriard A,Bauderlique-Le Roy H,Debrie AS,Coutte L,Locht C
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Fri Jan 08 00:00:00 EST 2021
STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer.
Cellular and molecular gastroenterology and hepatology
Vonderhaar EP,Barnekow NS,McAllister D,McOlash L,Eid MA,Riese MJ,Tarakanova VL,Johnson BD,Dwinell MB
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Mon Jan 24 00:00:00 EST 2022
GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure.
Cell death & disease
Yu H,Yang W,Huang J,Miao X,Wang B,Ren X,Gu Y,Wang Q,Ding X,Guo X,Qian F,Zhang Y,Xu H,Zheng L,Jin M
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Thu Dec 16 00:00:00 EST 2021
Blockade of IDO-Kynurenine-AhR Axis Ameliorated Colitis-Associated Colon Cancer via Inhibiting Immune Tolerance.
Cellular and molecular gastroenterology and hepatology
Zhang X,Liu X,Zhou W,Du Q,Yang M,Ding Y,Hu R
14-0691-82 was used in Flow Cytometry to demonstrate that inhibition of IDO diminished Kyn/AhR-mediated Treg differentiation and could be an effective strategy for the prevention and treatment of inflammation-related colon cancer.
Fri Mar 25 00:00:00 EDT 2022
Robust induction of TRMs by combinatorial nanoshells confers cross-strain sterilizing immunity against lethal influenza viruses.
Molecular therapy. Methods & clinical development
Lin PH,Liang CY,Yao BY,Chen HW,Pan CF,Wu LL,Lin YH,Hsu YS,Liu YH,Chen PJ,Hu CJ,Yang HC
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Fri Jun 11 00:00:00 EDT 2021
SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis.
iScience
Sangaletti S,Botti L,Gulino A,Lecis D,Bassani B,Portararo P,Milani M,Cancila V,De Cecco L,Dugo M,Tripodo C,Colombo MP
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Fri Jun 25 00:00:00 EDT 2021
Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection.
Cell
Ho JSY,Angel M,Ma Y,Sloan E,Wang G,Martinez-Romero C,Alenquer M,Roudko V,Chung L,Zheng S,Chang M,Fstkchyan Y,Clohisey S,Dinan AM,Gibbs J,Gifford R,Shen R,Gu Q,Irigoyen N,Campisi L,Huang C,Zhao N,Jones JD,van Knippenberg I,Zhu Z,Moshkina N,Meyer L,Noel J,Peralta Z,Rezelj V,Kaake R,Rosenberg B,Wang B,Wei J,Paessler S,Wise HM,Johnson J,Vannini A,Amorim MJ,Baillie JK,Miraldi ER,Benner C,Brierley I,Digard P,Łuksza M,Firth AE,Krogan N,Greenbaum BD,MacLeod MK,van Bakel H,Garcìa-Sastre A,Yewdell JW,Hutchinson E,Marazzi I
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Thu Jun 25 00:00:00 EDT 2020
B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection.
The Journal of experimental medicine
Arroyo EN,Pepper M
14-0691-82 was used in Flow Cytometry to study antigen-specific CD4+ T follicular helper (Tfh) cells responding to Plasmodium infection in order to understand the generation and maintenance of the Tfh response.
Mon Feb 03 00:00:00 EST 2020
Contact-dependent delivery of IL-2 by dendritic cells to CD4 T cells in the contraction phase promotes their long-term survival.
Protein & cell
Tong D,Zhang L,Ning F,Xu Y,Hu X,Shi Y
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in ELISA
Sat Feb 01 00:00:00 EST 2020
Contact-dependent delivery of IL-2 by dendritic cells to CD4 T cells in the contraction phase promotes their long-term survival.
Protein & cell
Tong D,Zhang L,Ning F,Xu Y,Hu X,Shi Y
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in ELISA
Sat Feb 01 00:00:00 EST 2020
Conserved T-cell epitopes of respiratory syncytial virus (RSV) delivered by recombinant live attenuated influenza vaccine viruses efficiently induce RSV-specific lung-localized memory T cells and augment influenza-specific resident memory T-cell responses.
Antiviral research
Matyushenko V,Kotomina T,Kudryavtsev I,Mezhenskaya D,Prokopenko P,Matushkina A,Sivak K,Muzhikyan A,Rudenko L,Isakova-Sivak I
14-0691-82 was used in Flow Cytometry to assess the induction of influenza- and respiratory syncytial virus-specific T cells in response to live attenuated influenza vaccine vector-based vaccination.
Thu Oct 01 00:00:00 EDT 2020
T-B Lymphocyte Interactions Promote Type 1 Diabetes Independently of SLAM-Associated Protein.
Journal of immunology (Baltimore, Md. : 1950)
Bonami RH,Nyhoff LE,McNitt DH,Hulbert C,Felton JL,Kendall PL,Thomas JW
14-0691-82 was used in Flow Cytometry to understand how fully developed T follicular helper cells contribute to different autoimmune processes, investigating the role of signaling lymphocytic activation molecule-associated protein in type 1 diabetes and autoantibody-mediated arthritis.
Tue Dec 15 00:00:00 EST 2020
Increase in liver γδ T cells with concurrent augmentation of IFN-β production during the early stages of a mouse model of acute experimental hepatitis B virus infection.
Experimental and therapeutic medicine
Chang L,Wang L,Ling N,Peng H,Chen M
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Wed Jan 01 00:00:00 EST 2020
Effects of CD4+ T lymphocytes from ovariectomized mice on bone marrow mesenchymal stem cell proliferation and osteogenic differentiation.
Experimental and therapeutic medicine
Shao BY,Wang L,Yu Y,Chen L,Gan N,Huang WM
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Sun Nov 01 00:00:00 EDT 2020
Potentiating the Antitumor Activity of Cytotoxic T Cells via the Transmembrane Domain of IGSF4 That Increases TCR Avidity.
Frontiers in immunology
Kim HR,Park JS,Fatima Y,Kausar M,Park JH,Jun CD
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Tue Jul 27 00:00:00 EDT 2021
Targeting the orphan nuclear receptor NR2F6 in T cells primes tumors for immune checkpoint therapy.
Cell communication and signaling : CCS
Klepsch V,Pommermayr M,Humer D,Brigo N,Hermann-Kleiter N,Baier G
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Tue Jan 14 00:00:00 EST 2020
SLAMF6 deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint.
eLife
Hajaj E,Eisenberg G,Klein S,Frankenburg S,Merims S,Ben David I,Eisenhaure T,Henrickson SE,Villani AC,Hacohen N,Abudi N,Abramovich R,Cohen JE,Peretz T,Veillette A,Lotem M
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Tue Mar 03 00:00:00 EST 2020
Loss of testosterone impairs anti-tumor neutrophil function.
Nature communications
Markman JL,Porritt RA,Wakita D,Lane ME,Martinon D,Noval Rivas M,Luu M,Posadas EM,Crother TR,Arditi M
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Tue Mar 31 00:00:00 EDT 2020
Commensal Microbiota Promote Lung Cancer Development via γδ T Cells.
Cell
Jin C,Lagoudas GK,Zhao C,Bullman S,Bhutkar A,Hu B,Ameh S,Sandel D,Liang XS,Mazzilli S,Whary MT,Meyerson M,Germain R,Blainey PC,Fox JG,Jacks T
14-0691-82 was used in Flow Cytometry to link local microbiota-immune crosstalk to lung tumor development and thereby define key cellular and molecular mediators that may serve as effective targets in lung cancer intervention.
Thu Feb 21 00:00:00 EST 2019
The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors.
The Journal of experimental medicine
Železnjak J,Lisnić VJ,Popović B,Lisnić B,Babić M,Halenius A,L'Hernault A,Roviš TL,Hengel H,Erhard F,Redwood AJ,Vidal SM,Dölken L,Krmpotić A,Jonjić S
14-0691 was used in Flow cytometry/Cell sorting to solve a long-standing conundrum of how MCMV avoids recognition by NK cells, unravels a fundamental new viral immune evasion mechanism, and demonstrates how this forced the evolution of virus-specific activating MHC I-restricted Ly49 receptors.
Mon Aug 05 00:00:00 EDT 2019
Inhibition of T cell activation and function by the adaptor protein CIN85.
Science signaling
Kong MS,Hashimoto-Tane A,Kawashima Y,Sakuma M,Yokosuka T,Kometani K,Onishi R,Carpino N,Ohara O,Kurosaki T,Phua KK,Saito T
14-0691-82 was used in Flow Cytometry to show that CIN85 (Cbl-interacting protein of 85 kDa) limited T cell responses to T cell receptor stimulation.
Tue Feb 05 00:00:00 EST 2019
α-Lactosylceramide Protects Against iNKT-Mediated Murine Airway Hyperreactivity and Liver Injury Through Competitive Inhibition of Cd1d Binding.
Frontiers in chemistry
Lai AC,Chi PY,Thio CL,Han YC,Kao HN,Hsieh HW,Gervay-Hague J,Chang YJ
14-0691 was used in Flow cytometry/Cell sorting to study how inhibiting iNKT cell activation with α-Lactosylceramide can reduce development of murine airway hyperreactivity and liver injury by competing for CD1d binding.
Thu Oct 01 00:00:00 EDT 2020
IL-33 Augments Virus-Specific Memory T Cell Inflation and Potentiates the Efficacy of an Attenuated Cytomegalovirus-Based Vaccine.
Journal of immunology (Baltimore, Md. : 1950)
McLaren JE,Clement M,Marsden M,Miners KL,Llewellyn-Lacey S,Grant EJ,Rubina A,Gimeno Brias S,Gostick E,Stacey MA,Orr SJ,Stanton RJ,Ladell K,Price DA,Humphreys IR
14-0691 was used in Flow cytometry/Cell sorting to suggest that IL-33 could serve as a useful adjuvant to improve the efficacy of vaccines based on attenuated derivatives of CMV.
Fri Feb 01 00:00:00 EST 2019
CSF1R antagonism limits local restimulation of antiviral CD8+ T cells during viral encephalitis.
Journal of neuroinflammation
Funk KE,Klein RS
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Thu Jan 31 00:00:00 EST 2019
Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules.
NPJ vaccines
Andersen TK,Huszthy PC,Gopalakrishnan RP,Jacobsen JT,Fauskanger M,Tveita AA,Grødeland G,Bogen B
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Thu Oct 05 00:00:00 EDT 2023
Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis.
Nature communications
Lee HG,Lee JU,Kim DH,Lim S,Kang I,Choi JM
14-0691 was used in Flow cytometry/Cell sorting to reveal the innate-like pathogenic function of antigen non-related memory CD4+ T cells, which contribute to the development of autoimmune diseases.
Tue Feb 12 00:00:00 EST 2019
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Thu Jan 25 00:00:00 EST 2018
A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells.
Nature cell biology
Ma R,Ji T,Zhang H,Dong W,Chen X,Xu P,Chen D,Liang X,Yin X,Liu Y,Ma J,Tang K,Zhang Y,Peng Y,Lu J,Zhang Y,Qin X,Cao X,Wan Y,Huang B
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Mon Jan 01 00:00:00 EST 2018
Small-Molecule Inhibition of PD-1 Transcription Is an Effective Alternative to Antibody Blockade in Cancer Therapy.
Cancer research
Taylor A,Rothstein D,Rudd CE
14-0691 was used in Flow cytometry/Cell sorting to show how GSK-3 inhibitors that downregulate PD-1 expression can enhance CD8+ T-cell function in cancer therapy to a similar degree as PD-1 blocking antibodies, offering a next-generation approach in the design of immunotherapeutic approaches for cancer management.
Thu Feb 01 00:00:00 EST 2018
Intranasal delivery of adjuvant-free peptide nanofibers elicits resident CD8+ T cell responses.
Journal of controlled release : official journal of the Controlled Release Society
Si Y,Wen Y,Kelly SH,Chong AS,Collier JH
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Sat Jul 28 00:00:00 EDT 2018
MicroRNA-126 deficiency enhanced the activation and function of CD4+ T cells by elevating IRS-1 pathway.
Clinical and experimental immunology
Chu F,Hu Y,Zhou Y,Guo M,Lu J,Zheng W,Xu H,Zhao J,Xu L
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Thu Feb 01 00:00:00 EST 2018
Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.
Nature communications
Sun C,Lan P,Han Q,Huang M,Zhang Z,Xu G,Song J,Wang J,Wei H,Zhang J,Sun R,Zhang C,Tian Z
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Wed Mar 28 00:00:00 EDT 2018
MAIT cells contribute to protection against lethal influenza infection in vivo.
Nature communications
van Wilgenburg B,Loh L,Chen Z,Pediongco TJ,Wang H,Shi M,Zhao Z,Koutsakos M,Nüssing S,Sant S,Wang Z,D'Souza C,Jia X,Almeida CF,Kostenko L,Eckle SBG,Meehan BS,Kallies A,Godfrey DI,Reading PC,Corbett AJ,McCluskey J,Klenerman P,Kedzierska K,Hinks TSC
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Fri Nov 09 00:00:00 EST 2018
Homoharringtonine induced immune alteration for an Efficient Anti-tumor Response in Mouse Models of Non-small Cell Lung Adenocarcinoma Expressing Kras Mutation.
Scientific reports
Weng TY,Wu HF,Li CY,Hung YH,Chang YW,Chen YL,Hsu HP,Chen YH,Wang CY,Chang JY,Lai MD
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Tue May 29 00:00:00 EDT 2018
Development of a screening strategy for new modulators of T cell receptor signaling and T cell activation.
Scientific reports
Chen EW,Brzostek J,Gascoigne NRJ,Rybakin V
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Tue Jul 03 00:00:00 EDT 2018
A Type I Interferon and IL-10 Induced by Orientia tsutsugamushi Infection Suppresses Antigen-Specific T Cells and Their Memory Responses.
Frontiers in immunology
Min CK,Kim HI,Ha NY,Kim Y,Kwon EK,Yen NTH,Youn JI,Jeon YK,Inn KS,Choi MS,Cho NH
14-0691 was used in Flow cytometry/Cell sorting to show that the induction of the type I IFN/IL-10 axis by O. tsutsugamushi infection might play a significant role in the suppression of T cell responses and contribute to the short longevity of cell-mediated immunity, often observed in scrub typhus patients.
Mon Sep 30 00:00:00 EDT 2019
The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage.
Nature immunology
Shan Q,Zeng Z,Xing S,Li F,Hartwig SM,Gullicksrud JA,Kurup SP,Van Braeckel-Budimir N,Su Y,Martin MD,Varga SM,Taniuchi I,Harty JT,Peng W,Badovinac VP,Xue HH
14-0691 was used in Flow cytometry/Cell sorting to show that Runx3-mediated Tcf7 repression coordinately enforced acquisition of cytotoxic functions and protected the cytotoxic lineage integrity by preventing TFH-lineage deviation.
Tue Aug 01 00:00:00 EDT 2017
Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling.
The Journal of clinical investigation
Ying W,Wollam J,Ofrecio JM,Bandyopadhyay G,El Ouarrat D,Lee YS,Oh DY,Li P,Osborn O,Olefsky JM
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
IL-36 Signaling Facilitates Activation of the NLRP3 Inflammasome and IL-23/IL-17 Axis in Renal Inflammation and Fibrosis.
Journal of the American Society of Nephrology : JASN
Chi HH,Hua KF,Lin YC,Chu CL,Hsieh CY,Hsu YJ,Ka SM,Tsai YL,Liu FC,Chen A
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Sat Jul 01 00:00:00 EDT 2017
Suppression of interleukin-6 increases enterovirus A71 lethality in mice.
Journal of biomedical science
Wang LC,Yao HW,Chang CF,Wang SW,Wang SM,Chen SH
14-0691 was used in Flow cytometry/Cell sorting to raise caution over the use of anti-IL-6 antibody or pentoxifylline to reduce IL-6 for patient treatment.
Tue Dec 12 00:00:00 EST 2017
Prostate Cancer Cells Express More Androgen Receptor (AR) Following Androgen Deprivation, Improving Recognition by AR-Specific T Cells.
Cancer immunology research
Olson BM,Gamat M,Seliski J,Sawicki T,Jeffery J,Ellis L,Drake CG,Weichert J,McNeel DG
14-0691 was used in Flow cytometry/Cell sorting to suggest that ADT combined with AR-directed immunotherapy targets a major mechanism of resistance, overexpression of the AR.
Fri Dec 01 00:00:00 EST 2017
Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells.
PLoS pathogens
Danahy DB,Anthony SM,Jensen IJ,Hartwig SM,Shan Q,Xue HH,Harty JT,Griffith TS,Badovinac VP
14-0691-82 was used in Flow Cytometry to directly examine the impact of sepsis on tissue resident memory CD8+ T cells in mice.
Fri Sep 01 00:00:00 EDT 2017
Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice.
Acta pharmacologica Sinica
Zhou YQ,Weng XF,Dou R,Tan XS,Zhang TT,Fang JB,Wu XW
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2017
14-3-3 Proteins regulate K2P 5.1 surface expression on T lymphocytes.
Traffic (Copenhagen, Denmark)
Fernández-Orth J,Ehling P,Ruck T,Pankratz S,Hofmann MS,Landgraf P,Dieterich DC,Smalla KH,Kähne T,Seebohm G,Budde T,Wiendl H,Bittner S,Meuth SG
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2017
NK cells regulate CXCR2+ neutrophil recruitment during acute lung injury.
Journal of leukocyte biology
Hoegl S,Ehrentraut H,Brodsky KS,Victorino F,Golden-Mason L,Eltzschig HK,McNamee EN
14069182 was used in flow cytometry to elucidate the role of Tbet in acute lung injury
Wed Feb 01 00:00:00 EST 2017
IRF6 Regulates Alternative Activation by Suppressing PPARγ in Male Murine Macrophages.
Endocrinology
Li C,Ying W,Huang Z,Brehm T,Morin A,Vella AT,Zhou B
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Fri Sep 01 00:00:00 EDT 2017
Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses.
Nature communications
Wang Q,Ning H,Peng H,Wei L,Hou R,Hoft DF,Liu J
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Wed Oct 11 00:00:00 EDT 2017
Different antiviral effects of IFNα subtypes in a mouse model of HBV infection.
Scientific reports
Song J,Li S,Zhou Y,Liu J,Francois S,Lu M,Yang D,Dittmer U,Sutter K
14-0691 was used in Flow cytometry/Cell sorting to demonstrate distinct anti-HBV effects of different IFNα subtypes against HBV in the mouse model, which may be relevant for new therapeutic approaches.
Thu Mar 23 00:00:00 EDT 2017
Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity.
Nature immunology
Xing S,Li F,Zeng Z,Zhao Y,Yu S,Shan Q,Li Y,Phillips FC,Maina PK,Qi HH,Liu C,Zhu J,Pope RM,Musselman CA,Zeng C,Peng W,Xue HH
14-0691 was used in Flow cytometry/Cell sorting to reveal that sequence-specific transcription factors can utilise intrinsic HDAC activity to guard cell identity by repressing lineage-inappropriate genes.
Wed Jun 01 00:00:00 EDT 2016
A septin requirement differentiates autonomous and contact-facilitated T cell proliferation.
Nature immunology
Mujal AM,Gilden JK,Gérard A,Kinoshita M,Krummel MF
14-0691 was used in Flow cytometry/Cell sorting to characterise T cells lacking the septin cytoskeleton.
Tue Mar 01 00:00:00 EST 2016
TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors.
The Journal of clinical investigation
Doorduijn EM,Sluijter M,Querido BJ,Oliveira CC,Achour A,Ossendorp F,van der Burg SH,van Hall T
14-0691 was used in Flow cytometry/Cell sorting to analyse thymus selection and peripheral behaviour of T cells with specificity for the self-antigen known as T cell epitopes associated with impaired peptide processing (TEIPP).
Mon Feb 01 00:00:00 EST 2016
pDC therapy induces recovery from EAE by recruiting endogenous pDC to sites of CNS inflammation.
Journal of autoimmunity
Duraes FV,Lippens C,Steinbach K,Dubrot J,Brighouse D,Bendriss-Vermare N,Issazadeh-Navikas S,Merkler D,Hugues S
14-0691 was used in Flow cytometry/Cell sorting to investigate novel pDC-based cell therapies in autoimmune diseases, aiming at specifically modulating pathogenic cells that induce and sustain autoimmune inflammation.
Mon Feb 01 00:00:00 EST 2016
Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.
Journal of immunology (Baltimore, Md. : 1950)
Menendez CM,Jinkins JK,Carr DJ
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Mon Aug 15 00:00:00 EDT 2016
TNF and CD28 Signaling Play Unique but Complementary Roles in the Systemic Recruitment of Innate Immune Cells after Staphylococcus aureus Enterotoxin A Inhalation.
Journal of immunology (Baltimore, Md. : 1950)
Svedova J,Tsurutani N,Liu W,Khanna KM,Vella AT
14-0691 was used in Flow cytometry/Cell sorting to investigate how Staphylococcus aureus enterotoxins spread systemically and trigger inflammatory cascades.
Wed Jun 01 00:00:00 EDT 2016
Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells.
eLife
Allison KA,Sajti E,Collier JG,Gosselin D,Troutman TD,Stone EL,Hedrick SM,Glass CK
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Mon Jul 04 00:00:00 EDT 2016
MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation.
The Journal of clinical investigation
Ying W,Tseng A,Chang RC,Morin A,Brehm T,Triff K,Nair V,Zhuang G,Song H,Kanameni S,Wang H,Golding MC,Bazer FW,Chapkin RS,Safe S,Zhou B
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Mon Nov 02 00:00:00 EST 2015
Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo.
Science advances
Hoffmann MM,Molina-Mendiola C,Nelson AD,Parks CA,Reyes EE,Hansen MJ,Rajagopalan G,Pease LR,Schrum AG,Gil D
14-0691 was used in Flow cytometry/Cell sorting to investigate co-potentiation, showing that weak T-cell responses can be boosted to provide immunotherapy in vivo.
Thu Oct 01 00:00:00 EDT 2015
The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis.
Genes & development
Miyazaki M,Miyazaki K,Chen S,Chandra V,Wagatsuma K,Agata Y,Rodewald HR,Saito R,Chang AN,Varki N,Kawamoto H,Murre C
14-0691 was used in Flow cytometry/Cell sorting to show that Id2 and Id3 suppress the development and expansion of innate variant follicular helper T cells.
Sun Feb 15 00:00:00 EST 2015
PD-1 or PD-L1 Blockade Restores Antitumor Efficacy Following SSX2 Epitope-Modified DNA Vaccine Immunization.
Cancer immunology research
Rekoske BT,Smith HA,Olson BM,Maricque BB,McNeel DG
14-0691 was used in Flow cytometry/Cell sorting to determine that vaccines aimed at eliciting effector CD8(+) T cells may have improved function when combined with PD-1 pathway inhibitors.
Sat Aug 01 00:00:00 EDT 2015
LKB1 inhibition of NF-κB in B cells prevents T follicular helper cell differentiation and germinal center formation.
EMBO reports
Walsh NC,Waters LR,Fowler JA,Lin M,Cunningham CR,Brooks DG,Rehg JE,Morse HC,Teitell MA
14-0691 was used in Flow cytometry/Cell sorting to show that LKB1 expression in B cells maintains B-cell quiescence and prevents the premature formation of germinal centers.
Mon Jun 01 00:00:00 EDT 2015
Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells.
Frontiers in immunology
Vogel AJ,Brown DM
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Fri Jul 10 00:00:00 EDT 2015
Cytokine-Mediated Activation of NK Cells during Viral Infection.
Journal of virology
Freeman BE,Raué HP,Hill AB,Slifka MK
14-0691 was used in Flow cytometry/Cell sorting to study how cytokines interact to regulate natural killer cell function during viral infection.
Sat Aug 01 00:00:00 EDT 2015
γδ T cells promote inflammation and insulin resistance during high fat diet-induced obesity in mice.
Journal of leukocyte biology
Mehta P,Nuotio-Antar AM,Smith CW
14-0691 was used in Flow cytometry/Cell sorting to reveal that isolated γδ T cells directly stimulated RAW264.7 macrophage TNF-α expression but did not stimulate inflammatory mediator expression in 3T3-L1 adipocytes.
Thu Jan 01 00:00:00 EST 2015
TARM1 Is a Novel Leukocyte Receptor Complex-Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils.
Journal of immunology (Baltimore, Md. : 1950)
Radjabova V,Mastroeni P,Skjødt K,Zaccone P,de Bono B,Goodall JC,Chilvers ER,Juss JK,Jones DC,Trowsdale J,Barrow AD
14-0691 was used in Flow cytometry/Cell sorting to identify a novel leukocyte receptor, TARM1, and investigate the mechanisms underlying its proinflammatory effects.
Thu Oct 01 00:00:00 EDT 2015
Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance.
Journal of immunology (Baltimore, Md. : 1950)
O'Hagan KL,Choi J,Pryshchep O,Chernoff J,Phee H
14-0691 was used in Flow cytometry/Cell sorting to show a novel role for the actin cytoskeletal remodeling protein, p21-activated kinase 2, in Treg development and homeostasis.
Sat Aug 15 00:00:00 EDT 2015
Regulatory T cells require TCR signaling for their suppressive function.
Journal of immunology (Baltimore, Md. : 1950)
Schmidt AM,Lu W,Sindhava VJ,Huang Y,Burkhardt JK,Yang E,Riese MJ,Maltzman JS,Jordan MS,Kambayashi T
14-0691 was used in Flow cytometry/Cell sorting to reveal that T cell receptor-mediated PLCγ activation is required for Tregs to inhibit Tconv proliferation.
Fri May 01 00:00:00 EDT 2015
MFG-E8 Is Critical for Embryonic Stem Cell-Mediated T Cell Immunomodulation.
Stem cell reports
Tan Y,AlKhamees B,Jia D,Li L,Couture JF,Figeys D,Jinushi M,Wang L
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Tue Nov 10 00:00:00 EST 2015
Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication.
Oncoimmunology
Draghiciu O,Nijman HW,Hoogeboom BN,Meijerhof T,Daemen T
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Sun Mar 01 00:00:00 EST 2015
Bortezomib Plus Continuous B Cell Depletion Results in Sustained Plasma Cell Depletion and Amelioration of Lupus Nephritis in NZB/W F1 Mice.
PloS one
Khodadadi L,Cheng Q,Alexander T,Sercan-Alp Ö,Klotsche J,Radbruch A,Hiepe F,Hoyer BF,Taddeo A
14-0691 was used in Flow cytometry/Cell sorting to suggest that the effective depletion of LLPCs using bortezomib in combination with a therapy that continuously targeting B cells as their precursors may prevent the regeneration of autoreactive LLPCs.
Mon May 23 00:00:00 EDT 2016
Microglia Induce Neurotoxic IL-17+ γδ T Cells Dependent on TLR2, TLR4, and TLR9 Activation.
PloS one
Derkow K,Krüger C,Dembny P,Lehnardt S
14-0691 was used in Flow cytometry/Cell sorting to investigate the crosstalk between γδ T cells and microglia activated by Toll-like receptors in the context of neuronal damage.
Tue May 17 00:00:00 EDT 2016
DNAM-1 expression marks an alternative program of NK cell maturation.
Cell reports
Martinet L,Ferrari De Andrade L,Guillerey C,Lee JS,Liu J,Souza-Fonseca-Guimaraes F,Hutchinson DS,Kolesnik TB,Nicholson SE,Huntington ND,Smyth MJ
14-0691 was used in Flow cytometry/Cell sorting to reveal the existence of a functional program of NK cell maturation marked by DNAM-1 expression.
Tue Apr 07 00:00:00 EDT 2015
Higher Sensitivity of Foxp3+ Treg Compared to Foxp3- Conventional T Cells to TCR-Independent Signals for CD69 Induction.
PloS one
Bremser A,Brack M,Izcue A
14-0691 was used in Flow cytometry/Cell sorting to investigate the effects of TCR signals on T cells through studying the expression of T cell activation marker CD69.
Tue May 24 00:00:00 EDT 2016
DNA Repair Cofactors ATMIN and NBS1 Are Required to Suppress T Cell Activation.
PLoS genetics
Prochazkova J,Sakaguchi S,Owusu M,Mazouzi A,Wiedner M,Velimezi G,Moder M,Turchinovich G,Hladik A,Gurnhofer E,Hayday A,Behrens A,Knapp S,Kenner L,Ellmeier W,Loizou JI
14-0691 was used in Flow cytometry/Cell sorting to investigate the roles of ATMIN and NBS1, either alone or in combination, in T cells.
Sun Nov 01 00:00:00 EDT 2015
Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction.
Nature communications
Rouhani SJ,Eccles JD,Riccardi P,Peske JD,Tewalt EF,Cohen JN,Liblau R,Mäkinen T,Engelhard VH
14-0691 was used in Flow cytometry/Cell sorting to demonstrate that when β-galactosidase (β-gal) is expressed in LECs, β-gal-specific CD8 T cells undergo deletion via the PD-1/PD-L1 and LAG-3/MHC-II pathways.
Fri Apr 10 00:00:00 EDT 2015
Herpes virus entry mediator licenses Listeria infection induced immunopathology through control of type I interferon.
Scientific reports
Lv M,Wu W,Zhang Y,Zhu M
14-0691 was used in Flow cytometry/Cell sorting to reveal a novel role of HVEM on the regulation of IFN-I and immunopathology during Listeria infection.
Thu Aug 06 00:00:00 EDT 2015
CCL2/CCR2-dependent recruitment of functional antigen-presenting cells into tumors upon chemotherapy.
Cancer research
Ma Y,Mattarollo SR,Adjemian S,Yang H,Aymeric L,Hannani D,Portela Catani JP,Duret H,Teng MW,Kepp O,Wang Y,Sistigu A,Schultze JL,Stoll G,Galluzzi L,Zitvogel L,Smyth MJ,Kroemer G
14-0691 was used in Flow cytometry/Cell sorting to underscore the importance of the CCL2/CCR2 signaling axis for therapeutic anticancer immune responses as elicited by immunogenic chemotherapy.
Wed Jan 15 00:00:00 EST 2014
Gemcitabine enhances the efficacy of reovirus-based oncotherapy through anti-tumour immunological mechanisms.
British journal of cancer
Gujar SA,Clements D,Dielschneider R,Helson E,Marcato P,Lee PW
14-0691 was used in Flow cytometry/Cell sorting to demonstrate that reovirus and gemcitabine combination treatment postpones peritoneal carcinomatosis development and prolongs the survival of cancer-bearing hosts.
Tue Jan 07 00:00:00 EST 2014
Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondii.
Immunology and cell biology
Han SJ,Melichar HJ,Coombes JL,Chan SW,Koshy AA,Boothroyd JC,Barton GM,Robey EA
14-0691 was used in Flow cytometry/Cell sorting to show that inflammatory monocytes, but not neutrophils, produce IFN-β in response to T. gondii infection.
Sat Nov 01 00:00:00 EDT 2014
In vivo functional mapping of the conserved protein domains within murine Themis1.
Immunology and cell biology
Zvezdova E,Lee J,El-Khoury D,Barr V,Akpan I,Samelson L,Love PE
14-0691 was used in Flow cytometry/Cell sorting to investigate the functional importance of different Themis1 domains.
Mon Sep 01 00:00:00 EDT 2014
Lysophosphatidic acid receptor 5 inhibits B cell antigen receptor signaling and antibody response.
Journal of immunology (Baltimore, Md. : 1950)
Hu J,Oda SK,Shotts K,Donovan EE,Strauch P,Pujanauski LM,Victorino F,Al-Shami A,Fujiwara Y,Tigyi G,Oravecz T,Pelanda R,Torres RM
14-0691 was used in Flow cytometry/Cell sorting to reveal that alterations in lysophosphatidic acid levels likely influence adaptive humoural immunity.
Tue Jul 01 00:00:00 EDT 2014
Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions.
Journal of immunology (Baltimore, Md. : 1950)
Duong S,Condotta SA,Rai D,Martin MD,Griffith TS,Badovinac VP
14-0691 was used in Flow cytometry/Cell sorting to study the role of sepsis in shaping the quantity and functionality of infection- or vaccine-induced memory CD8 T cells.
Tue Apr 15 00:00:00 EDT 2014
Skin-resident T cells sense ultraviolet radiation-induced injury and contribute to DNA repair.
Journal of immunology (Baltimore, Md. : 1950)
MacLeod AS,Rudolph R,Corriden R,Ye I,Garijo O,Havran WL
14-0691 was used in Flow cytometry/Cell sorting to establish a novel role for skin-resident T cells in the UVR-associated DNA repair response and underscore the importance of skin-resident T cells to overall skin regeneration.
Sun Jun 15 00:00:00 EDT 2014
Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock.
PloS one
Hou H,Liu W,Wu S,Lu Y,Peng J,Zhu Y,Lu Y,Wang F,Sun Z
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Mon Jul 06 00:00:00 EDT 2015
Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells.
eLife
Sojka DK,Plougastel-Douglas B,Yang L,Pak-Wittel MA,Artyomov MN,Ivanova Y,Zhong C,Chase JM,Rothman PB,Yu J,Riley JK,Zhu J,Tian Z,Yokoyama WM
14-0691 was used in Flow cytometry/Cell sorting to investigate whether tissue-resident and cells resembling conventional splenic natural killer cells natural killer cells are derived from the same lineage, showing that there are at least four distinct lineages.
Wed Jan 01 00:00:00 EST 2014
Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.
PloS one
May SL,Zhou Q,Lewellen M,Carter CM,Coffey D,Highfill SL,Bucher CM,Matise I,Morse HC,O'Sullivan MG,Schutten M,Johnson C,Bellgrau D,Blazar BR,Modiano JF
14-0691 was used in Flow cytometry/Cell sorting to study how Nfatc2 and Tob1 are non-redundant regulators of lymphocyte homeostasis.
Mon Oct 19 00:00:00 EDT 2015
The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling.
Nature immunology
Gracias DT,Stelekati E,Hope JL,Boesteanu AC,Doering TA,Norton J,Mueller YM,Fraietta JA,Wherry EJ,Turner M,Katsikis PD
14-0691 was used in Flow cytometry/Cell sorting to study the role of miR-155 in the regulation of CD8(+) T cell interferon responses to pathogens in vivo.
Sat Jun 01 00:00:00 EDT 2013
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.
The Journal of clinical investigation
Sukumar M,Liu J,Ji Y,Subramanian M,Crompton JG,Yu Z,Roychoudhuri R,Palmer DC,Muranski P,Karoly ED,Mohney RP,Klebanoff CA,Lal A,Finkel T,Restifo NP,Gattinoni L
14-0691 was used in Flow cytometry/Cell sorting to indicate that augmenting glycolytic flux drives CD8+ T-cells toward a terminally differentiated state.
Tue Oct 01 00:00:00 EDT 2013
Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment.
Cancer research
Baird JR,Fox BA,Sanders KL,Lizotte PH,Cubillos-Ruiz JR,Scarlett UK,Rutkowski MR,Conejo-Garcia JR,Fiering S,Bzik DJ
14-0691 was used in Flow cytometry/Cell sorting to establish that cps preferentially invades tumour-associated antigen-presenting cells and restores their ability to trigger potent anti-tumour CD8(+) T-cell responses.
Mon Jul 01 00:00:00 EDT 2013
Diacylglycerol kinase ζ limits the generation of natural regulatory T cells.
Science signaling
Schmidt AM,Zou T,Joshi RP,Leichner TM,Pimentel MA,Sommers CL,Kambayashi T
14-0691 was used in Flow cytometry/Cell sorting to identify critical signal events in nT(reg) cell development, showing that diacylglycerol kinase ζ limits the generation of nT(reg) cells.
Tue Nov 26 00:00:00 EST 2013
Aged mice exhibit a severely diminished CD8 T cell response following respiratory syncytial virus infection.
Journal of virology
Fulton RB,Weiss KA,Pewe LL,Harty JT,Varga SM
14-0691 was used in Flow cytometry/Cell sorting to investigate the extent to which CD8 T cell response to respiratory syncytial virus is altered with age, showing that age severely diminishes response.
Sun Dec 01 00:00:00 EST 2013
Protease activity enhances production of thymic stromal lymphopoietin and basophil accumulation in flaky tail mice.
The American journal of pathology
Moniaga CS,Jeong SK,Egawa G,Nakajima S,Hara-Chikuma M,Jeon JE,Lee SH,Hibino T,Miyachi Y,Kabashima K
14-0691 was used in Flow cytometry/Cell sorting to study the interplay between cellular protease activity and filaggrin deficiency in epidermal barrier abnormality as a predisposing factor in atopic dermatitis.
Fri Mar 01 00:00:00 EST 2013
Examining T cells at vaccine sites of tumor-bearing hosts provides insights to dysfunctional T-cell immunity.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Barr KM,Jing W,Hallett WH,Gershan JA,Johnson BD
14-0691 was used in Flow cytometry/Cell sorting to examine immune effectors at vaccine sites to identify mechanisms responsible for the generation of ineffective antitumor immunity, providing insights to dysfunctional T-cell immunity.
Tue Jan 01 00:00:00 EST 2013
Molecular definition of the identity and activation of natural killer cells.
Nature immunology
Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL
14-0691 was used in Flow cytometry/Cell sorting to systematically define the transcriptome of mouse natural killer cells in several contexts.
Mon Oct 01 00:00:00 EDT 2012
Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells.
Blood
Tewalt EF,Cohen JN,Rouhani SJ,Guidi CJ,Qiao H,Fahl SP,Conaway MR,Bender TP,Tung KS,Vella AT,Adler AJ,Chen L,Engelhard VH
14-0691 was used in Flow cytometry/Cell sorting to demonstrate that LECs mediate deletion only via programmed cell death-1 (PD-1) ligand 1.
Thu Dec 06 00:00:00 EST 2012
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
The Journal of experimental medicine
Billiard F,Lobry C,Darrasse-Jèze G,Waite J,Liu X,Mouquet H,DaNave A,Tait M,Idoyaga J,Leboeuf M,Kyratsous CA,Burton J,Kalter J,Klinakis A,Zhang W,Thurston G,Merad M,Steinman RM,Murphy AJ,Yancopoulos GD,Aifantis I,Skokos D
14-0691 was used in Flow cytometry/Cell sorting to investigate how Dll4-Notch signaling affects pro-T cell fate and thymic DC development, showing that it is a novel Flt3-independent pathway for DC development and autoimmunity.
Mon May 07 00:00:00 EDT 2012
IPS-1 signaling has a nonredundant role in mediating antiviral responses and the clearance of respiratory syncytial virus.
Journal of immunology (Baltimore, Md. : 1950)
Demoor T,Petersen BC,Morris S,Mukherjee S,Ptaschinski C,De Almeida Nagata DE,Kawai T,Ito T,Akira S,Kunkel SL,Schaller MA,Lukacs NW
14-0691-82 was used in Flow Cytometry to support a nonredundant function for IFN-β promoter stimulator in controlling respiratory syncytial virus-induced inflammation and viral replication.
Sat Dec 15 00:00:00 EST 2012
Expression of XCR1 Characterizes the Batf3-Dependent Lineage of Dendritic Cells Capable of Antigen Cross-Presentation.
Frontiers in immunology
Bachem A,Hartung E,Güttler S,Mora A,Zhou X,Hegemann A,Plantinga M,Mazzini E,Stoitzner P,Gurka S,Henn V,Mages HW,Kroczek RA
14-0691 was used in Flow cytometry/Cell sorting to provide evidence that expression of XCR1 throughout the body defines the Batf3-dependent lineage of DCs with a special capacity to cross-present antigen.
Thu Aug 23 00:00:00 EDT 2012
TGF-β sensitivity restrains CD8+ T cell homeostatic proliferation by enforcing sensitivity to IL-7 and IL-15.
PloS one
Johnson LD,Jameson SC
14-0691 was used in Flow cytometry/Cell sorting to analyse the response of transgenic naive CD8+ T cells with impaired TGF-β sensitivity to lymphopenia.
Thu Jan 10 00:00:00 EST 2013
NK cells suppress experimental cholestatic liver injury by an interleukin-6-mediated, Kupffer cell-dependent mechanism.
Journal of hepatology
Cheng CW,Duwaerts CC,Rooijen Nv,Wintermeyer P,Mott S,Gregory SH
14-0691 was used in Flow cytometry/Cell sorting to investigate the response of NK cells to liver injury that occurs in a mouse model of biliary obstruction.
Fri Apr 01 00:00:00 EDT 2011
Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells.
The Journal of experimental medicine
Hickman HD,Li L,Reynoso GV,Rubin EJ,Skon CN,Mays JW,Gibbs J,Schwartz O,Bennink JR,Yewdell JW
14-0691 was used in Flow cytometry/Cell sorting to demonstrate the ability of chemokines to assist antiviral CD8(+) T cells in distinguishing between antigen presenting cells.
Mon Nov 21 00:00:00 EST 2011
Centrosome docking at the immunological synapse is controlled by Lck signaling.
The Journal of cell biology
Tsun A,Qureshi I,Stinchcombe JC,Jenkins MR,de la Roche M,Kleczkowska J,Zamoyska R,Griffiths GM
14-0691 was used in Flow cytometry/Cell sorting to investigate the role of Lck signalling in the control of centrosome docking at the immunological synapse.
Mon Feb 21 00:00:00 EST 2011
Dicer insufficiency and microRNA-155 overexpression in lupus regulatory T cells: an apparent paradox in the setting of an inflammatory milieu.
Journal of immunology (Baltimore, Md. : 1950)
Divekar AA,Dubey S,Gangalum PR,Singh RR
14-0691 was used in Flow cytometry/Cell sorting to investigate mechanisms of potential Treg cell defects in systemic lupus erythematosus.
Sat Jan 15 00:00:00 EST 2011
A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells.
Journal of immunology (Baltimore, Md. : 1950)
Hoves S,Sutton VR,Haynes NM,Hawkins ED,Fernández Ruiz D,Baschuk N,Sedelies KA,Schnurr M,Stagg J,Andrews DM,Villadangos JA,Trapani JA
14-0691 was used in Flow cytometry/Cell sorting to reveal a critical and previously unsuspected role for granzymes A and B in dictating immunogenicity by influencing the mode of tumour cell death.
Mon Aug 01 00:00:00 EDT 2011
Rescue of tumor-infiltrating lymphocytes from activation-induced cell death enhances the antitumor CTL response in CD5-deficient mice.
Journal of immunology (Baltimore, Md. : 1950)
Tabbekh M,Franciszkiewicz K,Haouas H,Lécluse Y,Benihoud K,Raman C,Mami-Chouaib F
14-0691-82 was used in Flow Cytometry to compare the T cell response to the B16F10 melanoma engrafted into CD5-deficient and wild-type C57BL/6 mice.
Fri Jul 01 00:00:00 EDT 2011
NKT cells are required for complete Freund's adjuvant-mediated protection from autoimmune diabetes.
Journal of immunology (Baltimore, Md. : 1950)
Lee IF,van den Elzen P,Tan R,Priatel JJ
14-0691 was used in Flow cytometry/Cell sorting to elucidate roles for NKT cells in the adjuvant-promoting effects of CFA on innate and adaptive immunity.
Thu Sep 15 00:00:00 EDT 2011
Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis.
Nature communications
Mkhikian H,Grigorian A,Li CF,Chen HL,Newton B,Zhou RW,Beeton C,Torossian S,Tatarian GG,Lee SU,Lau K,Walker E,Siminovitch KA,Chandy KG,Yu Z,Dennis JW,Demetriou M
14-0691 was used in Flow cytometry/Cell sorting to discover that genetic and the environment converge to dysregulate N-glycosylation in multiple sclerosis.
Tue Sep 20 00:00:00 EDT 2011
Type I IFN enhances follicular B cell contribution to the T cell-independent antibody response.
The Journal of experimental medicine
Swanson CL,Wilson TJ,Strauch P,Colonna M,Pelanda R,Torres RM
14-0691 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which toll-like receptor ligands influence T cell-independent type 2 antibody responses.
Mon Jul 05 00:00:00 EDT 2010
Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites.
PLoS pathogens
Schmidt NW,Butler NS,Badovinac VP,Harty JT
14-0691 was used in Flow cytometry/Cell sorting to identify and track whole-parasite, RAS-vaccine-induced effector and memory CD8 T cell responses.
Thu Jul 15 00:00:00 EDT 2010
Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection.
Journal of immunology (Baltimore, Md. : 1950)
McCarl CA,Khalil S,Ma J,Oh-hora M,Yamashita M,Roether J,Kawasaki T,Jairaman A,Sasaki Y,Prakriya M,Feske S
14-0691 was used in Flow cytometry/Cell sorting to reaffirm the critical role of ORAI1 for T cell function, and provide important insights into the in vivo functions of CRAC channels for T cell-mediated immunity.
Mon Nov 15 00:00:00 EST 2010
ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation.
Journal of immunology (Baltimore, Md. : 1950)
Armstrong AJ,Gebre AK,Parks JS,Hedrick CC
14-0691 was used in Flow cytometry/Cell sorting to demonstrate that ATP-binding cassette transporter G1 regulates cholesterol homeostasis in thymocytes and peripheral CD4 T cells.
Fri Jan 01 00:00:00 EST 2010
Essential role for IL-27 receptor signaling in prevention of Th1-mediated immunopathology during malaria infection.
Journal of immunology (Baltimore, Md. : 1950)
Findlay EG,Greig R,Stumhofer JS,Hafalla JC,de Souza JB,Saris CJ,Hunter CA,Riley EM,Couper KN
14-0691 was used in Flow cytometry/Cell sorting to demonstrate the essential role of IL-27R signalling in regulating effector T cell function during malaria infection.
Sun Aug 15 00:00:00 EDT 2010
Depleting syndecan-4+ T lymphocytes using toxin-bearing dendritic cell-associated heparan sulfate proteoglycan-dependent integrin ligand: a new opportunity for treating activated T cell-driven disease.
Journal of immunology (Baltimore, Md. : 1950)
Akiyoshi H,Chung JS,Tomihari M,Cruz PD,Ariizumi K
14-0691 was used in Flow cytometry/Cell sorting to investigate whether the DC-HIL/SD-4 pathway could be a therapeutic target for conditions mediated by selectively activated T cells.
Thu Apr 01 00:00:00 EDT 2010
PI3 kinase signals BCR-dependent mature B cell survival.
Cell
Srinivasan L,Sasaki Y,Calado DP,Zhang B,Paik JH,DePinho RA,Kutok JL,Kearney JF,Otipoby KL,Rajewsky K
14-0691 was used in Flow cytometry/Cell sorting to identify the molecular nature of the essential B cell survival signal delivered to BCRs.
Fri Oct 30 00:00:00 EDT 2009
Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury.
The Journal of clinical investigation
Heymann F,Meyer-Schwesinger C,Hamilton-Williams EE,Hammerich L,Panzer U,Kaden S,Quaggin SE,Floege J,Gröne HJ,Kurts C
14-0691 was used in Flow cytometry/Cell sorting to investigate the role of several immune cell types within tubulointerstitial mononuclear cell infiltrates in the progression of kidney disease.
Fri May 01 00:00:00 EDT 2009
Coxsackievirus B3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the MHC class I pathway.
PLoS pathogens
Kemball CC,Harkins S,Whitmire JK,Flynn CT,Feuer R,Whitton JL
14-0691 was used in Flow cytometry/Cell sorting to evaluate in vitro and in vivo antigen presentation by coxsackievirus B3, showing that it inhibits antigen presentation in vivo.
Thu Oct 01 00:00:00 EDT 2009
Critical roles of lysosomal acid lipase in T cell development and function.
The American journal of pathology
Qu P,Du H,Wilkes DS,Yan C
14-0691-82 was used in Flow Cytometry to conclude that the altered development and function of lal(-/-) T cells contributes to disease formation in various organs during LAL deficiency.
Sun Mar 01 00:00:00 EST 2009
An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2.
The Journal of experimental medicine
Cho JH,Boyman O,Kim HO,Hahm B,Rubinstein MP,Ramsey C,Kim DM,Surh CD,Sprent J
14-0691 was used in Flow cytometry/Cell sorting to describe a novel form of homeostatic proliferation that occurs when naive T cells encounter raised levels of IL-2 and IL-15 in vivo.
Mon Aug 06 00:00:00 EDT 2007
Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis.
The Journal of experimental medicine
Crozat K,Hoebe K,Ugolini S,Hong NA,Janssen E,Rutschmann S,Mudd S,Sovath S,Vivier E,Beutler B
14-0691-82 was used in Flow Cytometry to identify a disruption of mouse orthologue of human MUNC13-4 which enables infectious triggering of type 3 familial hemophagocytic lymphohistiocytosis.
Mon Apr 16 00:00:00 EDT 2007
Modulation of naive CD4+ T-cell responses to an airway antigen during pulmonary mycobacterial infection.
Infection and immunity
Anis MM,Fulton SA,Reba SM,Harding CV,Boom WH
Published figure using CD69 monoclonal antibody (Product # 14-0691-82) in Flow Cytometry
Tue May 01 00:00:00 EDT 2007
Control of T Cell-mediated autoimmunity by metabolite flux to N-glycan biosynthesis.
The Journal of biological chemistry
Grigorian A,Lee SU,Tian W,Chen IJ,Gao G,Mendelsohn R,Dennis JW,Demetriou M
14-0691 was used in Flow cytometry/Cell sorting to investigate how the environment influences susceptibility to autoimmunity, showing that autoimmunity can be controlled through metabolite flux to N-glycan biosynthesis.
Fri Jul 06 00:00:00 EDT 2007
N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration.
The Journal of biological chemistry
Lee SU,Grigorian A,Pawling J,Chen IJ,Gao G,Mozaffar T,McKerlie C,Demetriou M
14-0691 was used in Flow cytometry/Cell sorting to identify hypomorphic Golgi processing as an inherited trait that determines susceptibility to EAE and provides a unique spontaneous model of MS.
Fri Nov 16 00:00:00 EST 2007
