Product References
Carvacrol protects mice against LPS-induced sepsis and attenuates inflammatory response in macrophages by modulating the ERK1/2 pathway.
Scientific reports
Yan C,Kuang W,Jin L,Wang R,Niu L,Xie C,Ding J,Liao Y,Wang L,Wan H,Ma G
Published figure using CD40 monoclonal antibody (Product # 16-0402-82) in Flow Cytometry
Mon Aug 07 00:00:00 EDT 2023
Curcumin-dependent phenotypic transformation of microglia mediates resistance to pseudorabies-induced encephalitis.
Veterinary research
Feng L,Luo G,Li Y,Zhang C,Liu Y,Liu Y,Chen H,He D,Zhu Y,Gan L
Published figure using CD40 monoclonal antibody (Product # 16-0402-82) in Flow Cytometry
Tue Mar 14 00:00:00 EDT 2023
An Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas.
Cancer discovery
Venturutti L,Rivas MA,Pelzer BW,Flümann R,Hansen J,Karagiannidis I,Xia M,McNally DR,Isshiki Y,Lytle A,Teater M,Chin CR,Meydan C,Knittel G,Ricker E,Mason CE,Ye X,Pan-Hammarström Q,Steidl C,Scott DW,Reinhardt HC,Pernis AB,Béguelin W,Melnick AM
16-0402-82 was used in Sample Prep to show that B cells expressing Myd88L252P (MYD88L265P murine equivalent) activate, proliferate, and differentiate with minimal T-cell costimulation.
Mon Jan 09 00:00:00 EST 2023
PP2Cδ Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway.
Frontiers in immunology
Lv N,Jin S,Liang Z,Wu X,Kang Y,Su L,Dong Y,Wang B,Ma T,Shi L
Published figure using CD40 monoclonal antibody (Product # 16-0402-82) in Flow Cytometry
Mon Feb 28 00:00:00 EST 2022
AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ.
Cell reports
Jiang Y,Dong Y,Luo Y,Jiang S,Meng FL,Tan M,Li J,Zang Y
16-0402-82 was used in Western Blot to demonstrate that AMPK is a regulator of 53BP1 and controls c-NHEJ choice by phospho-regulation.
Tue Feb 16 00:00:00 EST 2021
ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells.
Cell research
Liu X,Liu T,Shang Y,Dai P,Zhang W,Lee BJ,Huang M,Yang D,Wu Q,Liu LD,Zheng X,Zhou BO,Dong J,Yeap LS,Hu J,Xiao T,Zha S,Casellas R,Liu XS,Meng FL
16-0402-85 was used in CSR assay to identify the Snf2-family helicase-like ERCC6L2 as a factor channel chromatin breaks to deletional CSR in lymphocytes.
Tue Sep 01 00:00:00 EDT 2020
E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases.
The Journal of clinical investigation
Wang Z,Zhao M,Yin J,Liu L,Hu L,Huang Y,Liu A,Ouyang J,Min X,Rao S,Zhou W,Wu H,Yoshimura A,Lu Q
16-0402 was used in Flow cytometry/Cell sorting to study the mediatory role of the adenovirus E4BP4 within Tfh cell differentiation and study the immunological changes seen within patients with systemic lupus erythematosus.
Wed Jul 01 00:00:00 EDT 2020
Conditional antibody expression to avoid central B cell deletion in humanized HIV-1 vaccine mouse models.
Proceedings of the National Academy of Sciences of the United States of America
Tian M,McGovern K,Cheng HL,Waddicor P,Rieble L,Dao M,Chen Y,Kimble MT,Cantor E,Manfredonia N,Judson R,Chapdelaine-Williams A,Cain DW,Haynes BF,Alt FW
16-0402-85 was used in Flow Cytometry to test a vaccine which circumvents B cell developmental blocks.
Tue Apr 07 00:00:00 EDT 2020
REV7 is required for processing AID initiated DNA lesions in activated B cells.
Nature communications
Yang D,Sun Y,Chen J,Zhang Y,Fan S,Huang M,Xie X,Cai Y,Shang Y,Gui T,Sun L,Hu J,Dong J,Yeap LS,Wang X,Xiao W,Meng FL
16-0402-85 was used in In vitro Assay to identify that REV7-depedent TLS across UNG-processed apurinic/apyrimidinic sites is required for cell survival upon AID/APOBEC deamination.
Thu Jun 04 00:00:00 EDT 2020
REV7 is required for processing AID initiated DNA lesions in activated B cells.
Nature communications
Yang D,Sun Y,Chen J,Zhang Y,Fan S,Huang M,Xie X,Cai Y,Shang Y,Gui T,Sun L,Hu J,Dong J,Yeap LS,Wang X,Xiao W,Meng FL
16-0402-85 was used in In vitro Assay to identify that REV7-depedent TLS across UNG-processed apurinic/apyrimidinic sites is required for cell survival upon AID/APOBEC deamination.
Thu Jun 04 00:00:00 EDT 2020
REV7 is required for processing AID initiated DNA lesions in activated B cells.
Nature communications
Yang D,Sun Y,Chen J,Zhang Y,Fan S,Huang M,Xie X,Cai Y,Shang Y,Gui T,Sun L,Hu J,Dong J,Yeap LS,Wang X,Xiao W,Meng FL
16-0402-85 was used in In vitro Assay to identify that REV7-depedent TLS across UNG-processed apurinic/apyrimidinic sites is required for cell survival upon AID/APOBEC deamination.
Thu Jun 04 00:00:00 EDT 2020
Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.
Communications biology
Oikawa D,Sato Y,Ohtake F,Komakura K,Hanada K,Sugawara K,Terawaki S,Mizukami Y,Phuong HT,Iio K,Obika S,Fukushi M,Irie T,Tsuruta D,Sakamoto S,Tanaka K,Saeki Y,Fukai S,Tokunaga F
16-0402 was used in Functional assays to show that HOIPINs down-regulate not only the proinflammatory cytokine-induced canonical NF-κB pathway, but also various pathogen-associated molecular pattern-induced antiviral pathways.
Fri Apr 03 00:00:00 EDT 2020
TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells.
The FEBS journal
Schoeler K,Aufschnaiter A,Messner S,Derudder E,Herzog S,Villunger A,Rajewsky K,Labi V
Published figure using CD40 monoclonal antibody (Product # 16-0402-82) in Flow Cytometry
Sun Sep 01 00:00:00 EDT 2019
The B Cell Activation-Induced miR-183 Cluster Plays a Minimal Role in Canonical Primary Humoral Responses.
Journal of immunology (Baltimore, Md. : 1950)
Pucella JN,Cols M,Yen WF,Xu S,Chaudhuri J
16-0402-82 was used in Flow Cytometry to investigate the role of miR-182 in plasmablast differentiation.
Fri Mar 01 00:00:00 EST 2019
cGAS/STING/TBK1/IRF3 Signaling Pathway Activates BMDCs Maturation Following Mycobacterium bovis Infection.
International journal of molecular sciences
Li Q,Liu C,Yue R,El-Ashram S,Wang J,He X,Zhao D,Zhou X,Xu L
Published figure using CD40 monoclonal antibody (Product # 16-0402-82) in Flow Cytometry
Tue Feb 19 00:00:00 EST 2019
Distinct Requirements of CHD4 during B Cell Development and Antibody Response.
Cell reports
Yen WF,Sharma R,Cols M,Lau CM,Chaudhry A,Chowdhury P,Yewdell WT,Vaidyanathan B,Sun A,Coffre M,Pucella JN,Chen CC,Jasin M,Sun JC,Rudensky AY,Koralov SB,Chaudhuri J
16-0402 was used in Flow cytometry/Cell sorting to reveal distinct roles for CHD4 in B cell development and CSR and links the H3K9me3 epigenetic mark with AID recruitment to the Igh locus.
Tue Apr 30 00:00:00 EDT 2019
The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes.
Cell research
Chen J,Cai Z,Bai M,Yu X,Zhang C,Cao C,Hu X,Wang L,Su R,Wang D,Wang L,Yao Y,Ye R,Hou B,Yu Y,Yu S,Li J,Xue Y
16-0402 was used in Functional assays to identify an RNA-binding protein that is both required and sufficient to define activation-induced cytidine deaminase-binding sites genome-wide in activated B cells.
Mon Oct 01 00:00:00 EDT 2018
MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining.
Molecular cell
Hung PJ,Johnson B,Chen BR,Byrum AK,Bredemeyer AL,Yewdell WT,Johnson TE,Lee BJ,Deivasigamani S,Hindi I,Amatya P,Gross ML,Paull TT,Pisapia DJ,Chaudhuri J,Petrini JJH,Mosammaparast N,Amarasinghe GK,Zha S,Tyler JK,Sleckman BP
16-0402 was used in Flow cytometry/Cell sorting to investigate if in G1-phase XRCC4 and the XRCC4-like factor-deficient lymphocytes, the modulator of retrovirus infection is required for cNHEJ-mediated repair of DNA double-strand breaks generated by RAG and the I-PpoI endonuclease.
Thu Jul 19 00:00:00 EDT 2018
Environmental sensing by mature B cells is controlled by the transcription factors PU.1 and SpiB.
Nature communications
Willis SN,Tellier J,Liao Y,Trezise S,Light A,O'Donnell K,Garrett-Sinha LA,Shi W,Tarlinton DM,Nutt SL
Published figure using CD40 monoclonal antibody (Product # 16-0402-82) in Flow Cytometry
Fri Nov 10 00:00:00 EST 2017
Der f 31, a novel allergen from Dermatophagoides farinae, activates epithelial cells and enhances lung-resident group 2 innate lymphoid cells.
Scientific reports
Wang H,Lin J,Zeng L,Ouyang C,Ran P,Yang P,Liu Z
Published figure using CD40 monoclonal antibody (Product # 16-0402-82) in Flow Cytometry
Thu Aug 17 00:00:00 EDT 2017
Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining.
Proceedings of the National Academy of Sciences of the United States of America
Lu G,Duan J,Shu S,Wang X,Gao L,Guo J,Zhang Y
16-0402 was used in Flow cytometry/Cell sorting to dissect the roles of multiple DNA ligases in mediating the last step of alternative end-joining, and reveal the specificity of different ligase-containing complexes.
Tue Feb 02 00:00:00 EST 2016
Redundant function of DNA ligase 1 and 3 in alternative end-joining during immunoglobulin class switch recombination.
Proceedings of the National Academy of Sciences of the United States of America
Masani S,Han L,Meek K,Yu K
16-0402 was used in Flow cytometry/Cell sorting to demonstrate redundant function of Lig1 and Lig3 in resolving switch region double-strand breaks during class switch recombination.
Tue Feb 02 00:00:00 EST 2016
Semaphorin 4C: A Novel Component of B-Cell Polarization in Th2-Driven Immune Responses.
Frontiers in immunology
Xue D,Desjardins M,Kaufman GN,Béland M,Al-Tamemi S,Ahmed E,Tao S,Friedel RH,Mourad W,Mazer BD
16-0402 was used in Functional assays to report that Semaphorin 4C is inducible in human and murine B-cells and may be important for normal B-cell development.
Wed Nov 20 00:00:00 EST 2019
Thiol peroxiredoxin, a novel allergen from Bombyx mori, modulates functions of macrophages and dendritic cells.
American journal of translational research
Wang H,Hu W,Liang Z,Zeng L,Li J,Yan H,Yang P,Liu Z,Wang L
Published figure using CD40 monoclonal antibody (Product # 16-0402-82) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2020
Checkpoint kinase 2 is required for efficient immunoglobulin diversification.
Cell cycle (Georgetown, Tex.)
Davari K,Frankenberger S,Schmidt A,Tomi NS,Jungnickel B
16-0402 was used in Flow cytometry/Cell sorting to investigate the role of checkpoint kinase 2 in immunoglobulin diversification through regulation of Ig hypermutation, class switching and gene conversion.
Thu Sep 10 00:00:00 EDT 2015
p38 MAPK-inhibited dendritic cells induce superior antitumour immune responses and overcome regulatory T-cell-mediated immunosuppression.
Nature communications
Lu Y,Zhang M,Wang S,Hong B,Wang Z,Li H,Zheng Y,Yang J,Davis RE,Qian J,Hou J,Yi Q
16-0402 was used in Inhibition experiments to assess the anti-tumour immune response induced by p38 MAPK-inhibited dendritic cells, and its ability to overcome regulatory T-cell-mediated immunosuppression.
Tue Jun 24 00:00:00 EDT 2014
DNA ligase I is not essential for mammalian cell viability.
Cell reports
Han L,Masani S,Hsieh CL,Yu K
16-0402 was used in Flow cytometry/Cell sorting to demonstrate that DNA ligase I is not absolutely required for cellular DNA replication and repair.
Thu Apr 24 00:00:00 EDT 2014
MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways.
The EMBO journal
Jin HY,Oda H,Lai M,Skalsky RL,Bethel K,Shepherd J,Kang SG,Liu WH,Sabouri-Ghomi M,Cullen BR,Rajewsky K,Xiao C
16-0402 was used in Functional assays to show that elevated miR-17∼92 expression is sufficient to drive lymphomagenesis and, conversely, miR-17∼92 is essential for Myc-mediated lymphoma development.
Wed Aug 28 00:00:00 EDT 2013
A Complex Relationship between TRAF3 and Non-Canonical NF-κB2 Activation in B Lymphocytes.
Frontiers in immunology
Lin WW,Hildebrand JM,Bishop GA
16-0402 was used in Immunoprecipitation to conclude that there is not a simple linear relationship in B lymphocytes between relative levels of cellular TRAF3, induced TRAF3 degradation, NIK activation, and NF-κB2 activation.
Mon Jan 06 00:00:00 EST 2014
Apurinic/apyrimidinic endonuclease 1 is the essential nuclease during immunoglobulin class switch recombination.
Molecular and cellular biology
Masani S,Han L,Yu K
Mon Apr 01 00:00:00 EDT 2013
Apurinic/apyrimidinic endonuclease 1 is the essential nuclease during immunoglobulin class switch recombination.
Molecular and cellular biology
Masani S,Han L,Yu K
Mon Apr 01 00:00:00 EDT 2013
DNA damage activates a complex transcriptional response in murine lymphocytes that includes both physiological and cancer-predisposition programs.
BMC genomics
Innes CL,Hesse JE,Palii SS,Helmink BA,Holub AJ,Sleckman BP,Paules RS
Published figure using CD40 monoclonal antibody (Product # 16-0402-82) in Flow Cytometry
Tue Mar 12 00:00:00 EDT 2013
X-ray repair cross-complementing protein 1 (XRCC1) deficiency enhances class switch recombination and is permissive for alternative end joining.
Proceedings of the National Academy of Sciences of the United States of America
Han L,Mao W,Yu K
16-0402 was used in in vitro experiments to determine the role of x-ray repair cross-complementing protein 1 (XRCC1) in alternative end joining.
Tue Mar 20 00:00:00 EDT 2012
Immunogenicity and protective capacity of a virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A in mice.
PloS one
Kamphuis T,Meijerhof T,Stegmann T,Lederhofer J,Wilschut J,de Haan A
Published figure using CD40 monoclonal antibody (Product # 16-0402-82) in Flow Cytometry
Wed Sep 19 00:00:00 EDT 2012
Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination.
Proceedings of the National Academy of Sciences of the United States of America
Han L,Masani S,Yu K
16-0402 was used in Flow cytometry/Cell sorting to identify that the overlap of activation-induced cytidine deaminase hotspots at WGCW sites on the top and bottom strands is critical for Ig class-switch recombination.
Tue Jul 12 00:00:00 EDT 2011
Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70.
Proceedings of the National Academy of Sciences of the United States of America
Boboila C,Jankovic M,Yan CT,Wang JH,Wesemann DR,Zhang T,Fazeli A,Feldman L,Nussenzweig A,Nussenzweig M,Alt FW
16-0402 was used in Functional assays to study whether internal switch deletions and switch-region translocations occur in the complete absence of a single classical nonhomologous end-joining component.
Tue Feb 16 00:00:00 EST 2010
Antitumoral immune response by recruitment and expansion of dendritic cells in tumors infected with telomerase-dependent oncolytic viruses.
Cancer research
Edukulla R,Woller N,Mundt B,Knocke S,Gürlevik E,Saborowski M,Malek N,Manns MP,Wirth T,Kühnel F,Kubicka S
16-0402 was used in Flow cytometry/Cell sorting to investigate the effect of virotherapy in conjunction with MIP-1alpha and Flt3L in treating primary tumours, showing that triggering dendritic cell and t-cell infiltration can enhance treatment.
Sun Feb 15 00:00:00 EST 2009
Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS.
Glia
de Haas AH,Boddeke HW,Biber K
Published figure using CD40 monoclonal antibody (Product # 16-0402-82) in Flow Cytometry
Sun Jun 01 00:00:00 EDT 2008