Product References
BRCA1 deficiency in mature CD8+ T lymphocytes impairs antitumor immunity.
Journal for immunotherapy of cancer
Wu B,Qi L,Chiang HC,Pan H,Zhang X,Greenbaum A,Stark E,Wang LJ,Chen Y,Haddad BR,Clagett D,Isaacs C,Elledge R,Horvath A,Hu Y,Li R
Published figure using CD223 (LAG-3) monoclonal antibody (Product # 16-2231-85) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2023
Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling.
Nature communications
Xie F,Zhou X,Su P,Li H,Tu Y,Du J,Pan C,Wei X,Zheng M,Jin K,Miao L,Wang C,Meng X,van Dam H,Ten Dijke P,Zhang L,Zhou F
Published figure using CD223 (LAG-3) monoclonal antibody (Product # 16-2231-85) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2022
PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer.
Nature communications
Sun Y,Lu D,Yin Y,Song J,Liu Y,Hao W,Qi F,Zhang G,Zhang X,Liu L,Lin Z,Liang H,Zhao X,Jin Y,Yin Y
Published figure using CD223 (LAG-3) monoclonal antibody (Product # 16-2231-85) in Flow Cytometry
Thu Aug 26 00:00:00 EDT 2021
STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer.
Journal for immunotherapy of cancer
Lee SJ,Yang H,Kim WR,Lee YS,Lee WS,Kong SJ,Lee HJ,Kim JH,Cheon J,Kang B,Chon HJ,Kim C
16-2231-85 was used in Flow Cytometry to elucidate the immune-evasion mechanisms during the peritoneal carcinomatosis of colon cancer and developed a novel immunotherapy by activating the stimulator of interferon genes (STING) pathway.
Tue Jun 01 00:00:00 EDT 2021
Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer.
Cell
Ruscetti M,Morris JP,Mezzadra R,Russell J,Leibold J,Romesser PB,Simon J,Kulick A,Ho YJ,Fennell M,Li J,Norgard RJ,Wilkinson JE,Alonso-Curbelo D,Sridharan R,Heller DA,de Stanchina E,Stanger BZ,Sherr CJ,Lowe SW
16-2231 was used in Flow cytometry/Cell sorting to show that a combination of MEK and CDK4/6 inhibitors that target KRAS-directed oncogenic signaling can suppress PDAC proliferation through induction of retinoblastoma (RB) protein-mediated senescence.
Thu Apr 16 00:00:00 EDT 2020
Lactobacillus pentosus Modulates Immune Response by Inducing IL-10 Producing Tr1 Cells.
Immune network
Kim JE,Sharma A,Sharma G,Lee SY,Shin HS,Rudra D,Im SH
16-2231-85 was used in Flow Cytometry to demonstrate that LP340, a bacterium derived from food, prevents systemic inflammation through the induction of IL-10 producing Tr1 cells.
Sun Dec 01 00:00:00 EST 2019
Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation.
Nature communications
Yasuda K,Kitagawa Y,Kawakami R,Isaka Y,Watanabe H,Kondoh G,Kohwi-Shigematsu T,Sakaguchi S,Hirota K
Published figure using CD223 (LAG-3) monoclonal antibody (Product # 16-2231-85) in Flow Cytometry
Fri Feb 01 00:00:00 EST 2019
Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells.
Oncoimmunology
Salerno F,Guislain A,Freen-Van Heeren JJ,Nicolet BP,Young HA,Wolkers MC
16-2231 was used in Flow cytometry/Cell sorting to conclude that post-transcriptional mechanisms could be modulated to potentiate effective T cell therapies in cancer.
Tue Jan 12 00:00:00 EST 2021
Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology.
PLoS pathogens
Pyle CJ,Uwadiae FI,Swieboda DP,Harker JA
16-2231-85 was used in Flow Cytometry to show that during respiratory virus infection the prototypic inflammatory cytokine IL-6 is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27.
Fri Sep 01 00:00:00 EDT 2017
Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy.
Nature communications
Liu Z,Ravindranathan R,Kalinski P,Guo ZS,Bartlett DL
Published figure using CD223 (LAG-3) monoclonal antibody (Product # 16-2231-85) in Flow Cytometry
Mon Mar 27 00:00:00 EDT 2017
Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments.
Cell
Di Marco Barros R,Roberts NA,Dart RJ,Vantourout P,Jandke A,Nussbaumer O,Deban L,Cipolat S,Hart R,Iannitto ML,Laing A,Spencer-Dene B,East P,Gibbons D,Irving PM,Pereira P,Steinhoff U,Hayday A
Published figure using CD223 (LAG-3) monoclonal antibody (Product # 16-2231-85) in Flow Cytometry
Thu Sep 22 00:00:00 EDT 2016
Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.
Journal of immunology (Baltimore, Md. : 1950)
Menendez CM,Jinkins JK,Carr DJ
Published figure using CD223 (LAG-3) monoclonal antibody (Product # 16-2231-85) in Flow Cytometry
Mon Aug 15 00:00:00 EDT 2016
A Novel Model of Asymptomatic Plasmodium Parasitemia That Recapitulates Elements of the Human Immune Response to Chronic Infection.
PloS one
Fontana MF,Baccarella A,Craft JF,Boyle MJ,McIntyre TI,Wood MD,Thorn KS,Anidi C,Bayat A,Chung MR,Hamburger R,Kim CY,Pearman E,Pham J,Tang JJ,Boon L,Kamya MR,Dorsey G,Feeney ME,Kim CC
16-2231 was used in Flow cytometry/Cell sorting to investigate aspects of the human immune response to asymptomatic persistent Plasmodium infection using a novel animal model.
Wed Aug 02 00:00:00 EDT 2017
Liver sinusoidal endothelial cells induce tolerance of autoreactive CD4+ recent thymic emigrants.
Scientific reports
Xu X,Jin R,Li M,Wang K,Zhang S,Hao J,Sun X,Zhang Y,Wu H,Zhang J,Ge Q
16-2231 was used in Flow cytometry/Cell sorting to investigate the tolerance of liver-persisting CD4(+) recent thymic emigrants.
Fri Jan 22 00:00:00 EST 2016
Dendritic Cell-Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma.
Journal of immunology (Baltimore, Md. : 1950)
Dey M,Chang AL,Miska J,Wainwright DA,Ahmed AU,Balyasnikova IV,Pytel P,Han Y,Tobias A,Zhang L,Qiao J,Lesniak MS
16-2231 was used in Flow cytometry/Cell sorting to compare the ability of myeloid and plasmacytoid dendritic cells to generate effective antiglioma immunity.
Wed Jul 01 00:00:00 EDT 2015
Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction.
Nature communications
Rouhani SJ,Eccles JD,Riccardi P,Peske JD,Tewalt EF,Cohen JN,Liblau R,Mäkinen T,Engelhard VH
16-2231 was used in Flow cytometry/Cell sorting to demonstrate that when β-galactosidase (β-gal) is expressed in LECs, β-gal-specific CD8 T cells undergo deletion via the PD-1/PD-L1 and LAG-3/MHC-II pathways.
Fri Apr 10 00:00:00 EDT 2015
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.
Nature communications
Chen L,Gibbons DL,Goswami S,Cortez MA,Ahn YH,Byers LA,Zhang X,Yi X,Dwyer D,Lin W,Diao L,Wang J,Roybal J,Patel M,Ungewiss C,Peng D,Antonia S,Mediavilla-Varela M,Robertson G,Suraokar M,Welsh JW,Erez B,Wistuba II,Chen L,Peng D,Wang S,Ullrich SE,Heymach JV,Kurie JM,Qin FX
Published figure using CD223 (LAG-3) monoclonal antibody (Product # 16-2231-85) in Flow Cytometry
Tue Oct 28 00:00:00 EDT 2014
Comparison of induced versus natural regulatory T cells of the same TCR specificity for induction of tolerance to an environmental antigen.
Journal of immunology (Baltimore, Md. : 1950)
Huang H,Ma Y,Dawicki W,Zhang X,Gordon JR
16-2231 was used in Flow cytometry/Cell sorting to compare abilities of nTreg and iTreg cells to mediate tolerance in OVA-asthmatic C57BL/6 mice.
Thu Aug 01 00:00:00 EDT 2013
Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells.
Blood
Tewalt EF,Cohen JN,Rouhani SJ,Guidi CJ,Qiao H,Fahl SP,Conaway MR,Bender TP,Tung KS,Vella AT,Adler AJ,Chen L,Engelhard VH
16-2231 was used in Flow cytometry/Cell sorting to demonstrate that LECs mediate deletion only via programmed cell death-1 (PD-1) ligand 1.
Thu Dec 06 00:00:00 EST 2012
CD8 T cells recruited early in mouse polyomavirus infection undergo exhaustion.
Journal of immunology (Baltimore, Md. : 1950)
Wilson JJ,Pack CD,Lin E,Frost EL,Albrecht JA,Hadley A,Hofstetter AR,Tevethia SS,Schell TD,Lukacher AE
16-2231 was used in Flow cytometry/Cell sorting to characterise virus-specific CD8 T cells recruited during persistent infection.
Tue May 01 00:00:00 EDT 2012
CD70 expression by dendritic cells plays a critical role in the immunogenicity of CD40-independent, CD4+ T cell-dependent, licensed CD8+ T cell responses.
Journal of leukocyte biology
Van Deusen KE,Rajapakse R,Bullock TN
16-2231 was used in Blocking experiments to explain the capacity of CD40-deficient mice to mount CD8(+) T cell responses, which may provide targets for immunotherapy.
Mon Mar 01 00:00:00 EST 2010