Product References
R274X-mutated Phf6 increased the self-renewal and skewed T cell differentiation of hematopoietic stem cells.
iScience
Lan Y,Yuan S,Guo T,Hou S,Zhao F,Yang W,Cao Y,Chu Y,Jiang E,Yuan W,Wang X
17-0453-82 was used in Flow cytometry/Cell sorting to demonstrate that Phf6R274X plays a critical role in fine-tuning T cells and HSC homeostasis.
Fri Jun 16 00:00:00 EDT 2023
Niche-expressed Galectin-1 is involved in pre-B acute lymphoblastic leukemia relapse through pre-B cell receptor activation.
iScience
Pelletier J,Balzano M,Destin J,Montersino C,Delahaye MC,Marchand T,Bailly AL,Bardin F,Coppin E,Goubard A,Castellano R,de Bruijn MJW,Rip J,Collette Y,Dubreuil P,Tarte K,Broccardo C,Hendriks RW,Schiff C,Vey N,Aurrand-Lions M,Mancini SJC
17-0453-82 was used in Flow cytometry/Cell sorting to show that non-cell autonomous signals transmitted by BM niches represent promising targets to improve B-ALL patient survival.
Fri Apr 21 00:00:00 EDT 2023
Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis.
Science advances
Ma L,Tang Q,Gao X,Lee J,Lei R,Suzuki M,Zheng D,Ito K,Frenette PS,Dawlaty MM
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Fri Mar 04 00:00:00 EST 2022
cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory.
Science immunology
Christian DA,Adams TA,Shallberg LA,Phan AT,Smith TE,Abraha M,Perry J,Ruthel G,Clark JT,Pritchard GH,Aronson LR,Gossa S,McGavern DB,Kedl RM,Hunter CA
17-0453-82 was used in Flow Cytometry to investigate how conventional type 1 dendritic cells (cDC1s) in the peritoneal cavity's omentum coordinate innate responses to microbial challenge and provide secondary signals required for CD8+ T cell expansion and memory formation, particularly after intraperitoneal immunization with Toxoplasma gondii.
Fri Sep 30 00:00:00 EDT 2022
Optimal CD8+ T cell effector function requires costimulation-induced RNA-binding proteins that reprogram the transcript isoform landscape.
Nature communications
Karginov TA,Ménoret A,Vella AT
17-0453-82 was used in Flow cytometry/Cell sorting to demonstrate that RNA-binding protein Tardbp is required for effector cytokine production, CD8+ T cell clonal expansion, and isoform regulation after costimulation.
Mon Jun 20 00:00:00 EDT 2022
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
Nature immunology
Rivas MA,Meydan C,Chin CR,Challman MF,Kim D,Bhinder B,Kloetgen A,Viny AD,Teater MR,McNally DR,Doane AS,Béguelin W,Fernández MTC,Shen H,Wang X,Levine RL,Chen Z,Tsirigos A,Elemento O,Mason CE,Melnick AM
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Mon Jul 05 00:00:00 EDT 2021
Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling.
Cell reports
Young IC,Wu B,Andricovich J,Chuang ST,Li R,Tzatsos A,Wu RC,Wu MY
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Tue Nov 23 00:00:00 EST 2021
Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies.
Cell reports
Seydoux E,Wan YH,Feng J,Wall A,Aljedani S,Homad LJ,MacCamy AJ,Weidle C,Gray MD,Brumage L,Taylor JJ,Pancera M,Stamatatos L,McGuire AT
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Tue May 04 00:00:00 EDT 2021
Intestinal CD11b+ B Cells Ameliorate Colitis by Secreting Immunoglobulin A.
Frontiers in immunology
Fu Y,Wang Z,Yu B,Lin Y,Huang E,Liu R,Zhao C,Lu M,Xu W,Liu H,Liu Y,Wang L,Chu Y
17-0453-82 was used in Flow Cytometry to demonstrate that CD11b+ B cells are essential intestinal suppressive immune cells and the primary source of intestinal IgA, which plays an indispensable role in maintaining intestinal homeostasis.
Fri Jan 07 00:00:00 EST 2022
Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death.
Frontiers in immunology
Yang L,Chen W,Li L,Xiao Y,Fan S,Zhang Q,Xia T,Li M,Hong Y,Zhao T,Li Q,Liu WH,Xiao N
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Mon Dec 20 00:00:00 EST 2021
Protein kinase Cδ is essential for the IgG response against T-cell-independent type 2 antigens and commensal bacteria.
eLife
Fukao S,Haniuda K,Tamaki H,Kitamura D
17-0453-82 was used in Flow cytometry/Cell sorting to reveal novel molecular requirements for class switching in the TI-2 response and highlighted its importance in homeostatic commensal-specific IgG production.
Mon Oct 25 00:00:00 EDT 2021
Negative feedback by NUR77/Nr4a1 restrains B cell clonal dominance during early T-dependent immune responses.
Cell reports
Brooks JF,Tan C,Mueller JL,Hibiya K,Hiwa R,Vykunta V,Zikherman J
17-0453-82 was used in Flow cytometry/Cell sorting to investigate if a negative feedback loop may operate within B cells to preferentially restrain high-affinity clones from monopolizing the early GC niche.
Tue Aug 31 00:00:00 EDT 2021
DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization.
Cell death & disease
Liu L,Wu Y,Wang B,Jiang Y,Lin L,Li X,Yang S
17-0453 was used in Flow cytometry/Cell sorting to provide demonstration of DA-DRD5 signaling in colonic macrophages controlling the development of colitis by regulating M1/M2 macrophage polarization.
Mon May 17 00:00:00 EDT 2021
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.
Cancer cell
Su R,Dong L,Li Y,Gao M,Han L,Wunderlich M,Deng X,Li H,Huang Y,Gao L,Li C,Zhao Z,Robinson S,Tan B,Qing Y,Qin X,Prince E,Xie J,Qin H,Li W,Shen C,Sun J,Kulkarni P,Weng H,Huang H,Chen Z,Zhang B,Wu X,Olsen MJ,Müschen M,Marcucci G,Salgia R,Li L,Fathi AT,Li Z,Mulloy JC,Wei M,Horne D,Chen J
17-0453-82 was used in Flow Cytometry to demonstrate if fat mass and obesity-associated protein plays critical roles in cancer stem cell self-renewal and immune evasion.
Mon Jul 13 00:00:00 EDT 2020
Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development.
Cell stem cell
Crosse EI,Gordon-Keylock S,Rybtsov S,Binagui-Casas A,Felchle H,Nnadi NC,Kirschner K,Chandra T,Tamagno S,Webb DJ,Rossi F,Anderson RA,Medvinsky A
17-0453 was used in Flow cytometry/Cell sorting to identify secreted signals underlying human HSC development, combining spatial transcriptomics analysis of dorsoventral polarized signaling in the aorta with gene expression profiling of sorted cell populations and single cells.
Thu Nov 05 00:00:00 EST 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
Mast Cells Occupy Stable Clonal Territories in Adult Steady-State Skin.
The Journal of investigative dermatology
Weitzmann A,Naumann R,Dudeck A,Zerjatke T,Gerbaulet A,Roers A
17-0453 was used in Flow cytometry/Cell sorting to conclude that during a limited window early in development, definitive MC precursors efficiently enter the skin, expand, and self-maintain, occupying stable territories.
Tue Dec 01 00:00:00 EST 2020
RIPK3 and Caspase-1/11 Are Necessary for Optimal Antigen-Specific CD8 T Cell Response Elicited by Genetically Modified Listeria monocytogenes.
Frontiers in immunology
Rana A,de Almeida FC,Paico Montero HA,Gonzales Carazas MM,Bortoluci KR,Sad S,Amarante-Mendes GP
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Fri Mar 26 00:00:00 EDT 2021
SHP-1 Regulates Antigen Cross-Presentation and Is Exploited by Leishmania to Evade Immunity.
Cell reports
Khouili SC,Cook ECL,Hernández-García E,Martínez-López M,Conde-Garrosa R,Iborra S
17-0453 was used in Flow cytometry/Cell sorting to demonstrate that SHP-1 inhibition improves CD11c+ cell-based vaccination against the parasite.
Tue Dec 01 00:00:00 EST 2020
Engineering monocyte/macrophage-specific glucocerebrosidase expression in human hematopoietic stem cells using genome editing.
Nature communications
Scharenberg SG,Poletto E,Lucot KL,Colella P,Sheikali A,Montine TJ,Porteus MH,Gomez-Ospina N
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Fri Jul 03 00:00:00 EDT 2020
Bendamustine with total body irradiation conditioning yields tolerant T-cells while preserving T-cell-dependent graft-versus-leukemia.
Oncoimmunology
Stokes J,Hoffman EA,Molina MS,Kummet N,Simpson RJ,Zeng Y,Katsanis E
17-0453 was used in Flow cytometry/Cell sorting to demonstrate that BEN-TBI reduces graft-versus-host disease (GvHD) compared to CY-TBI independently of T regulatory cells (Tregs).
Wed Jul 14 00:00:00 EDT 2021
Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells.
Cell reports
Shin B,Benavides GA,Geng J,Koralov SB,Hu H,Darley-Usmar VM,Harrington LE
17-0453 was used in Flow cytometry/Cell sorting to study the role of mitochondrial oxidative phosphorylation in pathogenic Th17 differentiation.
Tue Feb 11 00:00:00 EST 2020
UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma.
Cell
Wolf Y,Bartok O,Patkar S,Eli GB,Cohen S,Litchfield K,Levy R,Jiménez-Sánchez A,Trabish S,Lee JS,Karathia H,Barnea E,Day CP,Cinnamon E,Stein I,Solomon A,Bitton L,Pérez-Guijarro E,Dubovik T,Shen-Orr SS,Miller ML,Merlino G,Levin Y,Pikarsky E,Eisenbach L,Admon A,Swanton C,Ruppin E,Samuels Y
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Thu Sep 19 00:00:00 EDT 2019
The cis-Regulatory Atlas of the Mouse Immune System.
Cell
Yoshida H,Lareau CA,Ramirez RN,Rose SA,Maier B,Wroblewska A,Desland F,Chudnovskiy A,Mortha A,Dominguez C,Tellier J,Kim E,Dwyer D,Shinton S,Nabekura T,Qi Y,Yu B,Robinette M,Kim KW,Wagers A,Rhoads A,Nutt SL,Brown BD,Mostafavi S,Buenrostro JD,Benoist C
17-0453-82 was used in Flow Cytometry to generate matched epigenome and transcriptome measurements in 86 primary cell types that span the mouse immune system and its differentiation cascade.
Thu Feb 07 00:00:00 EST 2019
Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity.
Immunity
Martínez-López M,Iborra S,Conde-Garrosa R,Mastrangelo A,Danne C,Mann ER,Reid DM,Gaboriau-Routhiau V,Chaparro M,Lorenzo MP,Minnerup L,Saz-Leal P,Slack E,Kemp B,Gisbert JP,Dzionek A,Robinson MJ,Rupérez FJ,Cerf-Bensussan N,Brown GD,Bernardo D,LeibundGut-Landmann S,Sancho D
17-0453-82 was used in Flow Cytometry to conclude that sensing of commensals by Mincle and Syk signaling in CD11c+ cells reinforces intestinal immune barrier and promotes host-microbiota mutualism, preventing systemic inflammation.
Tue Feb 19 00:00:00 EST 2019
Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer.
Immunity
Dmitrieva-Posocco O,Dzutsev A,Posocco DF,Hou V,Yuan W,Thovarai V,Mufazalov IA,Gunzer M,Shilovskiy IP,Khaitov MR,Trinchieri G,Waisman A,Grivennikov SI
17-0453-82 was used in Flow Cytometry to examine the impact of IL-1 signaling, a key regulator of the IL-17 pathway, in different cell types within the CRC microenvironment.
Tue Jan 15 00:00:00 EST 2019
The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy.
Cellular & molecular immunology
Moschovakis GL,Bubke A,Friedrichsen M,Ristenpart J,Back JW,Falk CS,Kremmer E,Förster R
17-0453-82 was used in Flow Cytometry to demonstrate that CCR7 signaling is essential for the induction of CIA and identify CCR7 as a potential therapeutic target in RA.
Tue Oct 01 00:00:00 EDT 2019
Formyl peptide receptor 2 regulates monocyte recruitment to promote intestinal mucosal wound repair.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Birkl D,O'Leary MN,Quiros M,Azcutia V,Schaller M,Reed M,Nishio H,Keeney J,Neish AS,Lukacs NW,Parkos CA,Nusrat A
17-0453-82 was used in Flow Cytometry to study how Fpr2/3 regulates CCL20-CCR6-mediated monocyte chemotaxis to sites of mucosal injury in the gut to influence wound repair.
Sun Dec 01 00:00:00 EST 2019
Direct CD137 costimulation of CD8 T cells promotes retention and innate-like function within nascent atherogenic foci.
American journal of physiology. Heart and circulatory physiology
Xu MM,Ménoret A,Nicholas SE,Günther S,Sundberg EJ,Zhou B,Rodriguez A,Murphy PA,Vella AT
17-0453 was used in Flow cytometry/Cell sorting to provide novel insight into CD137 costimulation of effector T cells, independent of plaque-antigen recognition, instigates their retention and promotes innate-like responses from immune infiltrates within atherogenic foci.
Sat Jun 01 00:00:00 EDT 2019
IL-12 Blocks Tfh Cell Differentiation during Salmonella Infection, thereby Contributing to Germinal Center Suppression.
Cell reports
Elsner RA,Shlomchik MJ
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Tue Nov 26 00:00:00 EST 2019
Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence.
Journal of visualized experiments : JoVE
Kesarwani M,Kincaid Z,Azam M
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Mon Jan 07 00:00:00 EST 2019
RNA and Toll-Like Receptor 7 License the Generation of Superior Secondary Plasma Cells at Multiple Levels in a B Cell Intrinsic Fashion.
Frontiers in immunology
Krueger CC,Thoms F,Keller E,Leoratti FMS,Vogel M,Bachmann MF
17-0453 was used in Flow cytometry/Cell sorting to investigate the effects of virus-like particles on secondary plasma cells.
Mon Sep 21 00:00:00 EDT 2020
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Thu Jan 25 00:00:00 EST 2018
IL1RAP potentiates multiple oncogenic signaling pathways in AML.
The Journal of experimental medicine
Mitchell K,Barreyro L,Todorova TI,Taylor SJ,Antony-Debré I,Narayanagari SR,Carvajal LA,Leite J,Piperdi Z,Pendurti G,Mantzaris I,Paietta E,Verma A,Gritsman K,Steidl U
17-0453 was used in Flow cytometry/Cell sorting to show that targeting of interleukin-1 receptor accessory protein via RNA interference, genetic deletion, or antibodies inhibits acute myeloid leukaemia pathogenesis in vitro and in vivo.
Mon Jun 04 00:00:00 EDT 2018
De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages.
Frontiers in immunology
Stüve P,Minarrieta L,Erdmann H,Arnold-Schrauf C,Swallow M,Guderian M,Krull F,Hölscher A,Ghorbani P,Behrends J,Abraham WR,Hölscher C,Sparwasser TD,Berod L
17-0453-82 was used in Flow Cytometry to reveal that acetyl-CoA carboxylase 1-dependent fatty acid synthesis is a crucial mechanism in T cells, but not dendritic cells or macrophages, to fight against mycobacterial infection.
Wed Apr 10 00:00:00 EDT 2019
The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice.
eLife
Schmidt K,Zhang Q,Tasdogan A,Petzold A,Dahl A,Arneth BM,Slany R,Fehling HJ,Kranz A,Stewart AF,Anastassiadis K
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Tue Jun 19 00:00:00 EDT 2018
An immune cell spray (ICS) formulation allows for the delivery of functional monocyte/macrophages.
Scientific reports
Beneke V,Küster F,Neehus AL,Hesse C,Lopez-Rodriguez E,Haake K,Rafiei Hashtchin A,Schott JW,Walter D,Braun A,Wolkers WF,Ackermann M,Lachmann N
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Fri Nov 02 00:00:00 EDT 2018
STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia.
Cell reports
Saint Fleur-Lominy S,Maus M,Vaeth M,Lange I,Zee I,Suh D,Liu C,Wu X,Tikhonova A,Aifantis I,Feske S
Tue Sep 11 00:00:00 EDT 2018
Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b.
Nature communications
Cho S,Lee HM,Yu IS,Choi YS,Huang HY,Hashemifar SS,Lin LL,Chen MC,Afanasiev ND,Khan AA,Lin SW,Rudensky AY,Crotty S,Lu LF
17-0453 was used in Flow cytometry/Cell sorting to reveal differential cell-intrinsic regulations of GC B and Tfh cells by miR-146a and miR-146b.
Mon Jul 16 00:00:00 EDT 2018
iPSC-Derived Macrophages Effectively Treat Pulmonary Alveolar Proteinosis in Csf2rb-Deficient Mice.
Stem cell reports
Mucci A,Lopez-Rodriguez E,Hetzel M,Liu S,Suzuki T,Happle C,Ackermann M,Kempf H,Hillje R,Kunkiel J,Janosz E,Brennig S,Glage S,Bankstahl JP,Dettmer S,Rodt T,Gohring G,Trapnell B,Hansen G,Trapnell C,Knudsen L,Lachmann N,Moritz T
17-0453 was used in Flow cytometry and IHC/IF to evaluate the airway residence, plasticity, and therapeutic efficacy of induced pluripotent stem cell-derived macrophages in a murine model of hereditary pulmonary alveolar proteinosis.
Tue Sep 11 00:00:00 EDT 2018
iPSC-Derived Macrophages Effectively Treat Pulmonary Alveolar Proteinosis in Csf2rb-Deficient Mice.
Stem cell reports
Mucci A,Lopez-Rodriguez E,Hetzel M,Liu S,Suzuki T,Happle C,Ackermann M,Kempf H,Hillje R,Kunkiel J,Janosz E,Brennig S,Glage S,Bankstahl JP,Dettmer S,Rodt T,Gohring G,Trapnell B,Hansen G,Trapnell C,Knudsen L,Lachmann N,Moritz T
17-0453 was used in Flow cytometry and IHC/IF to evaluate the airway residence, plasticity, and therapeutic efficacy of induced pluripotent stem cell-derived macrophages in a murine model of hereditary pulmonary alveolar proteinosis.
Tue Sep 11 00:00:00 EDT 2018
Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation.
Stem cell reports
Hamanaka S,Umino A,Sato H,Hayama T,Yanagida A,Mizuno N,Kobayashi T,Kasai M,Suchy FP,Yamazaki S,Masaki H,Yamaguchi T,Nakauchi H
Tue Oct 09 00:00:00 EDT 2018
Analysis of Runx1 Using Induced Gene Ablation Reveals Its Essential Role in Pre-liver HSC Development and Limitations of an In Vivo Approach.
Stem cell reports
Senserrich J,Batsivari A,Rybtsov S,Gordon-Keylock S,Souilhol C,Buchholz F,Hills D,Zhao S,Medvinsky A
17-0453-82 was used in Functional assays to study tamoxifen-inducible Runx1 inactivation in vivo.
Tue Sep 11 00:00:00 EDT 2018
Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring.
Nature
Kim S,Kim H,Yim YS,Ha S,Atarashi K,Tan TG,Longman RS,Honda K,Littman DR,Choi GB,Huh JR
17-0453 was used in Flow cytometry/Cell sorting to suggest that defined gut commensal bacteria with a propensity to induce TH17 cells may increase the risk of neurodevelopmental disorders in the offspring of pregnant mothers undergoing immune system activation owing to infections or autoinflammatory syndromes.
Thu Sep 28 00:00:00 EDT 2017
Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion.
Immunity
Minutti CM,Drube S,Blair N,Schwartz C,McCrae JC,McKenzie AN,Kamradt T,Mokry M,Coffer PJ,Sibilia M,Sijts AJ,Fallon PG,Maizels RM,Zaiss DM
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Tue Oct 17 00:00:00 EDT 2017
Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration.
Cell stem cell
Ambrosi TH,Scialdone A,Graja A,Gohlke S,Jank AM,Bocian C,Woelk L,Fan H,Logan DW,Schürmann A,Saraiva LR,Schulz TJ
17-0453 was used in Flow cytometry/Cell sorting to specify the cellular identities of the adipogenic and osteogenic lineages of the bone.
Thu Jun 01 00:00:00 EDT 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Mon Jun 05 00:00:00 EDT 2017
A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation.
The Journal of experimental medicine
McGarvey AC,Rybtsov S,Souilhol C,Tamagno S,Rice R,Hills D,Godwin D,Rice D,Tomlinson SR,Medvinsky A
17-0453 was used in Flow cytometry/Cell sorting to identify novel secreted regulators of haematopoietic stem cell maturation.
Mon Dec 04 00:00:00 EST 2017
CD4+ Th2 cells are directly regulated by IL-10 during allergic airway inflammation.
Mucosal immunology
Coomes SM,Kannan Y,Pelly VS,Entwistle LJ,Guidi R,Perez-Lloret J,Nikolov N,Müller W,Wilson MS
17-0453 was used in Flow cytometry/Cell sorting to identify that pathogenic Th2 cells are an important direct target of IL-10 and an insight into IL-10 mediated regualation of allergic airway inflammation.
Sun Jan 01 00:00:00 EST 2017
Immunogenicity of Isogenic IgG in Aggregates and Immune Complexes.
PloS one
St Clair JB,Detanico T,Aviszus K,Kirchenbaum GA,Christie M,Carpenter JF,Wysocki LJ
17-0453 was used in Flow cytometry/Cell sorting to analyse CD4 T cell reactions against IgG in various physical states.
Fri Aug 11 00:00:00 EDT 2017
Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome.
Nature communications
Shirai CL,White BS,Tripathi M,Tapia R,Ley JN,Ndonwi M,Kim S,Shao J,Carver A,Saez B,Fulton RS,Fronick C,O'Laughlin M,Lagisetti C,Webb TR,Graubert TA,Walter MJ
17-0453 was used in Flow cytometry/Cell sorting to suggest a potential for treating haematological cancers harbouring U2AF1 mutations with pre-mRNA splicing modulators like sudemycins.
Mon Jan 09 00:00:00 EST 2017
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Cell
Damgaard RB,Walker JA,Marco-Casanova P,Morgan NV,Titheradge HL,Elliott PR,McHale D,Maher ER,McKenzie ANJ,Komander D
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Thu Aug 25 00:00:00 EDT 2016
Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.
Cancer cell
Inoue S,Li WY,Tseng A,Beerman I,Elia AJ,Bendall SC,Lemonnier F,Kron KJ,Cescon DW,Hao Z,Lind EF,Takayama N,Planello AC,Shen SY,Shih AH,Larsen DM,Li Q,Snow BE,Wakeham A,Haight J,Gorrini C,Bassi C,Thu KL,Murakami K,Elford AR,Ueda T,Straley K,Yen KE,Melino G,Cimmino L,Aifantis I,Levine RL,De Carvalho DD,Lupien M,Rossi DJ,Nolan GP,Cairns RA,Mak TW
17-0453 was used in Flow cytometry/Cell sorting to discover that mice expressing endogenous mutant IDH1 have reduced numbers of hematopoietic stem cells (HSCs), in contrast to Tet2 knockout (TET2-KO) mice.
Mon Aug 08 00:00:00 EDT 2016
Developing HSCs become Notch independent by the end of maturation in the AGM region.
Blood
Souilhol C,Lendinez JG,Rybtsov S,Murphy F,Wilson H,Hills D,Batsivari A,Binagui-Casas A,McGarvey AC,MacDonald HR,Kageyama R,Siebel C,Zhao S,Medvinsky A
17-0453 was used in Flow cytometry/Cell sorting to investigate how Notch signalling regulates hematopoietic stem cell (HSC) formation in the embryo, showing that HSCs become Notch independent by the end of maturation in the aorta-gonad-mesonephros region.
Thu Sep 22 00:00:00 EDT 2016
NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells.
The Journal of experimental medicine
de Valle E,Grigoriadis G,O'Reilly LA,Willis SN,Maxwell MJ,Corcoran LM,Tsantikos E,Cornish JK,Fairfax KA,Vasanthakumar A,Febbraio MA,Hibbs ML,Pellegrini M,Banerjee A,Hodgkin PD,Kallies A,Mackay F,Strasser A,Gerondakis S,Gugasyan R
17-0453 was used in Flow cytometry/Cell sorting to identify a novel role of NFκB1 in preventing multiorgan autoimmunity through the negative regulation of Il-6 gene expression in follicular B cells.
Mon Apr 04 00:00:00 EDT 2016
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.
Stem cell reports
Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Tue Aug 09 00:00:00 EDT 2016
Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells.
Nature communications
Souilhol C,Gonneau C,Lendinez JG,Batsivari A,Rybtsov S,Wilson H,Morgado-Palacin L,Hills D,Taoudi S,Antonchuk J,Zhao S,Medvinsky A
17-0453 was used in Flow cytometry/Cell sorting to study how several signalling pathways interact to regulate the emergence of haematopoietic stem cells in the aorta.
Tue Mar 08 00:00:00 EST 2016
C-C chemokine receptor type-4 transduction of T cells enhances interaction with dendritic cells, tumor infiltration and therapeutic efficacy of adoptive T cell transfer.
Oncoimmunology
Rapp M,Grassmann S,Chaloupka M,Layritz P,Kruger S,Ormanns S,Rataj F,Janssen KP,Endres S,Anz D,Kobold S
17-0453 was used in Flow cytometry/Cell sorting to study how CCR4 overexpression in CTL is a promising therapeutic strategy to enhance the efficacy of adoptive T cell transfer (ACT).
Tue Mar 01 00:00:00 EST 2016
BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.
The Journal of experimental medicine
Jacque E,Schweighoffer E,Tybulewicz VL,Ley SC
17-0453 was used in Flow cytometry/Cell sorting to reveal a potentially critical role for the MEK5-ERK5 MAP kinase signalling pathway in BAFF-induced mature B cell survival and homeostatic maintenance of B2 cell numbers.
Mon Jun 01 00:00:00 EDT 2015
MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.
Proceedings of the National Academy of Sciences of the United States of America
Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Tue Dec 29 00:00:00 EST 2015
IFNγ and IL-12 Restrict Th2 Responses during Helminth/Plasmodium Co-Infection and Promote IFNγ from Th2 Cells.
PLoS pathogens
Coomes SM,Pelly VS,Kannan Y,Okoye IS,Czieso S,Entwistle LJ,Perez-Lloret J,Nikolov N,Potocnik AJ,Biró J,Langhorne J,Wilson MS
17-0453 was used in Flow cytometry/Cell sorting to show that co-infection with Plasmodium spp. may contribute to the chronicity of helminth infection by reducing the frequency of anti-helminth Th2 cells.
Wed Jul 01 00:00:00 EDT 2015
Dynamics and Transcriptomics of Skin Dendritic Cells and Macrophages in an Imiquimod-Induced, Biphasic Mouse Model of Psoriasis.
Journal of immunology (Baltimore, Md. : 1950)
Terhorst D,Chelbi R,Wohn C,Malosse C,Tamoutounour S,Jorquera A,Bajenoff M,Dalod M,Malissen B,Henri S
17-0453 was used in Flow cytometry/Cell sorting to develop and characterise an improved mouse model of psoriasis using imiquimod, showing that the dynamics and transcriptomics of skin dendritic cells and macrophages are similar to those seen in human pathology.
Sun Nov 15 00:00:00 EST 2015
Frizzled-6 Regulates Hematopoietic Stem/Progenitor Cell Survival and Self-Renewal.
Journal of immunology (Baltimore, Md. : 1950)
Abidin BM,Owusu Kwarteng E,Heinonen KM
17-0453 was used in Flow cytometry/Cell sorting to reveal that Fzd6 has an essential role in HSPC maintenance and survival.
Tue Sep 01 00:00:00 EDT 2015
Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis.
Nature communications
Xue J,Sharma V,Hsieh MH,Chawla A,Murali R,Pandol SJ,Habtezion A
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Mon May 18 00:00:00 EDT 2015
Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis.
Blood
Rodríguez-Díez E,Quereda V,Bellutti F,Prchal-Murphy M,Partida D,Eguren M,Kollmann K,Gómez de Cedrón M,Dubus P,Cañamero M,Martínez D,Sexl V,Malumbres M
17-0453 was used in Flow cytometry/Cell sorting to assess the role of Cdk4 and Cdk6 cooperation during the development of hematopoietic tumours.
Thu Oct 09 00:00:00 EDT 2014
WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.
The Journal of experimental medicine
Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Mon Sep 22 00:00:00 EDT 2014
PD-1 regulates extrathymic regulatory T-cell differentiation.
European journal of immunology
Chen X,Fosco D,Kline DE,Meng L,Nishi S,Savage PA,Kline J
17-0453 was used in Flow cytometry/Cell sorting to investigate the regulation of extrathymic regulatory T-cell differentiation by PD-1.
Mon Sep 01 00:00:00 EDT 2014
Tracing the origin of the HSC hierarchy reveals an SCF-dependent, IL-3-independent CD43(-) embryonic precursor.
Stem cell reports
Rybtsov S,Batsivari A,Bilotkach K,Paruzina D,Senserrich J,Nerushev O,Medvinsky A
17-0453 was used in Flow cytometry/Cell sorting to further define the hierarchical organisation of the developing haematopoietic stem cell lineage.
Tue Sep 09 00:00:00 EDT 2014
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.
Nature immunology
Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
Mouse extraembryonic arterial vessels harbor precursors capable of maturing into definitive HSCs.
Blood
Gordon-Keylock S,Sobiesiak M,Rybtsov S,Moore K,Medvinsky A
17-0453 was used in Flow cytometry/Cell sorting to elucidate the hematopoietic stem cell initiating potential of cell clusters in mouse extraembryonic vessels.
Thu Oct 03 00:00:00 EDT 2013
Host-derived CD8+ dendritic cells are required for induction of optimal graft-versus-tumor responses after experimental allogeneic bone marrow transplantation.
Blood
Toubai T,Sun Y,Luker G,Liu J,Luker KE,Tawara I,Evers R,Liu C,Mathewson N,Malter C,Nieves E,Choi S,Murphy KM,Reddy P
17-0453 was used in Flow cytometry/Cell sorting to show that a subset of host-derived APCs-CD8(+) dendritic cells enhances TSA responses and is required for optimal induction of GVT.
Thu May 16 00:00:00 EDT 2013
p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells.
The Journal of experimental medicine
Iannello A,Thompson TW,Ardolino M,Lowe SW,Raulet DH
17-0453 was used in Flow cytometry/Cell sorting to study how NK cells participate in the elimination of senescent tumours.
Mon Sep 23 00:00:00 EDT 2013
c-Rel is an essential transcription factor for the development of acute graft-versus-host disease in mice.
European journal of immunology
Yu Y,Wang D,Kaosaard K,Liu C,Fu J,Haarberg K,Anasetti C,Beg AA,Yu XZ
17-0453 was used in Flow cytometry/Cell sorting to investigate the role of c-Rel in transplant tolerance and graft-versus-host disease (GVHD), showing that it is an essential transcription factor for the development of acute GVHD.
Sun Sep 01 00:00:00 EDT 2013
CD22 is required for protection against West Nile virus Infection.
Journal of virology
Ma DY,Suthar MS,Kasahara S,Gale M,Clark EA
17-0453 was used in Flow cytometry/Cell sorting to elucidate the immunological requirements for an antibody response following West Nile virus infection.
Fri Mar 01 00:00:00 EST 2013
Arrayed lentiviral barcoding for quantification analysis of hematopoietic dynamics.
Stem cells (Dayton, Ohio)
Grosselin J,Sii-Felice K,Payen E,Chretien S,Tronik-Le Roux D,Leboulch P
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2013
BAFF controls neural cell survival through BAFF receptor.
PloS one
Tada S,Yasui T,Nakatsuji Y,Okuno T,Koda T,Mochizuki H,Sakoda S,Kikutani H
17-0453 was used in Flow cytometry/Cell sorting to examine the role of B-cell activating factor-receptor signalling in the control of neural cell survival.
Thu Aug 21 00:00:00 EDT 2014
G-CSF/anti-G-CSF antibody complexes drive the potent recovery and expansion of CD11b+Gr-1+ myeloid cells without compromising CD8+ T cell immune responses.
Journal of hematology & oncology
Rubinstein MP,Salem ML,Doedens AL,Moore CJ,Chiuzan C,Rivell GL,Cole DJ,Goldrath AW
17-0453 was used in Flow cytometry/Cell sorting to evaluate whether the biological activity of G-CSF can be improved by pre-association with anti-G-CSF monoclonal antibodies prior to injection.
Tue Oct 01 00:00:00 EDT 2013
Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance.
Immunity
Hadeiba H,Lahl K,Edalati A,Oderup C,Habtezion A,Pachynski R,Nguyen L,Ghodsi A,Adler S,Butcher EC
17-0453 was used in Flow cytometry/Cell sorting to explore the mechanisms underlying the contribution to immune tolerance conducted by peripheral dendritic cells.
Fri Mar 23 00:00:00 EDT 2012
NF-Y is necessary for hematopoietic stem cell proliferation and survival.
Blood
Bungartz G,Land H,Scadden DT,Emerson SG
17-0453 was used in Flow cytometry/Cell sorting to show that the trimeric transcription factor NF-Y is critical for the survival of cycling, but not quiescent hematopoietic stem cells.
Thu Feb 09 00:00:00 EST 2012
Trogocytosis of CD80 and CD86 by induced regulatory T cells.
Cellular & molecular immunology
Gu P,Gao JF,D'Souza CA,Kowalczyk A,Chou KY,Zhang L
17-0453 was used in Flow cytometry/Cell sorting to provide a novel understanding of the interaction between iTregs and DCs, and its role in iTreg-mediated immune suppression.
Thu Mar 01 00:00:00 EST 2012
Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory.
The Journal of experimental medicine
Kaji T,Ishige A,Hikida M,Taka J,Hijikata A,Kubo M,Nagashima T,Takahashi Y,Kurosaki T,Okada M,Ohara O,Rajewsky K,Takemori T
17-0453 was used in Flow cytometry/Cell sorting to reveal distinct cellular pathways that select germline-encoded and somatically mutated antibodies into immunological memory.
Mon Oct 22 00:00:00 EDT 2012
CD64 expression distinguishes monocyte-derived and conventional dendritic cells and reveals their distinct role during intramuscular immunization.
Journal of immunology (Baltimore, Md. : 1950)
Langlet C,Tamoutounour S,Henri S,Luche H,Ardouin L,Grégoire C,Malissen B,Guilliams M
17-0453 was used in Flow cytometry/Cell sorting to define the distinct DC subsets that reside in skeletal muscles and identify their migratory counterparts in draining LNs.
Wed Feb 15 00:00:00 EST 2012
A critical role for Rictor in T lymphopoiesis.
Journal of immunology (Baltimore, Md. : 1950)
Tang F,Wu Q,Ikenoue T,Guan KL,Liu Y,Zheng P
17-0453 was used in Flow cytometry/Cell sorting to investigate the signalling pathway required for T lymphopoiesis, showing a critical role for Rictor.
Wed Aug 15 00:00:00 EDT 2012
In vitro Ag Cross-presentation and in vivo Ag Cross-presentation by Dendritic Cells in the Mouse.
Bio-protocol
Ghosh M,Shapiro LH
Published figure using CD45.1 monoclonal antibody (Product # 17-0453-82) in Flow Cytometry
Thu Dec 20 00:00:00 EST 2012
The cytosolic protein G0S2 maintains quiescence in hematopoietic stem cells.
PloS one
Yamada T,Park CS,Burns A,Nakada D,Lacorazza HD
17-0453 was used in Flow cytometry/Cell sorting to elucidate the mechanisms behind the maintenance of the balance of differentiation and proliferation of HSCs.
Mon Oct 22 00:00:00 EDT 2012
Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.
Blood
Welch JS,Klco JM,Varghese N,Nagarajan R,Ley TJ
17-0453 was used in Flow cytometry/Cell sorting to test the prediction that RARA (retinoic acid receptor alpha) haploinsufficiency would contribute to acute promyelocytic leukemia (APL) pathogenesis.
Thu Feb 24 00:00:00 EST 2011
Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and RORγt in mice.
Blood
Yu Y,Wang D,Liu C,Kaosaard K,Semple K,Anasetti C,Yu XZ
17-0453 was used in Flow cytometry/Cell sorting to indicate that GVHD can be prevented by targeting Th1 and Th17 transcription factors without offsetting GVL activity.
Thu Nov 03 00:00:00 EDT 2011
PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice.
The Journal of clinical investigation
Welch JS,Yuan W,Ley TJ
17-0453 was used in Flow cytometry/Cell sorting to study a platform for more accurately dissecting the early events in acute promyelocytic leukemia pathogenesis.
Fri Apr 01 00:00:00 EDT 2011
Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region.
The Journal of experimental medicine
Rybtsov S,Sobiesiak M,Taoudi S,Souilhol C,Senserrich J,Liakhovitskaia A,Ivanovs A,Frampton J,Zhao S,Medvinsky A
17-0453 was used in Flow cytometry/Cell sorting to show that pre-HSCs are broadly distributed through the wall of the dorsal aorta, and propose a simple model for HSC development in the AGM region.
Mon Jun 06 00:00:00 EDT 2011
TLT2 potentiates neutrophil antibacterial activity and chemotaxis in response to G protein-coupled receptor-mediated signaling.
Journal of immunology (Baltimore, Md. : 1950)
Halpert MM,Thomas KA,King RG,Justement LB
17-0453 was used in Flow cytometry/Cell sorting to study how TLT2 appears to play an important role in enhancing the innate immune response via a novel molecular mechanism.
Thu Sep 01 00:00:00 EDT 2011
Human cardiac stem cells isolated from atrial appendages stably express c-kit.
PloS one
He JQ,Vu DM,Hunt G,Chugh A,Bhatnagar A,Bolli R
17-0453 was used in Flow cytometry/Cell sorting to investigate how a higher percentage of relative pure human CSCs with stable expression of c-kit+ could be obtained from atrial appendage specimens.
Mon Apr 09 00:00:00 EDT 2012
Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation.
The Journal of clinical investigation
Flutter B,Edwards N,Fallah-Arani F,Henderson S,Chai JG,Sivakumaran S,Ghorashian S,Bennett CL,Freeman GJ,Sykes M,Chakraverty R
17-0453 was used in Flow cytometry/Cell sorting to explore the role of recipient antigen expression by nonhaematopoietic cells in the failure to sustain effective cytotoxic T lymphocyte immunity following blood transplantation.
Mon Nov 01 00:00:00 EDT 2010
CD4+ T cells are not required for the induction of dengue virus-specific CD8+ T cell or antibody responses but contribute to protection after vaccination.
Journal of immunology (Baltimore, Md. : 1950)
Yauch LE,Prestwood TR,May MM,Morar MM,Zellweger RM,Peters B,Sette A,Shresta S
17-0453 was used in Flow cytometry/Cell sorting to investigate the contribution of T cells to the host response to dengue virus infection, showing that CD4+ T cells contribute to protection after vaccination but are not required for the induction of dengue virus-specific CD8+ T cell or antibody responses.
Mon Nov 01 00:00:00 EDT 2010
The endothelial antigen ESAM marks primitive hematopoietic progenitors throughout life in mice.
Blood
Yokota T,Oritani K,Butz S,Kokame K,Kincade PW,Miyata T,Vestweber D,Kanakura Y
17-0453 was used in Flow cytometry/Cell sorting to study hematopoietic stem cell (HSC) characteristics for improved understanding of their development and stage-related functions, showing that the endothelial antigen ESAM marks primitive hematopoietic progenitors throughout life in mice.
Thu Mar 26 00:00:00 EDT 2009
Cellular expression and antimicrobial function of a phylogenetically conserved novel histone 1x-like protein on mouse cells: a potential new class of pattern recognition receptor.
Journal of leukocyte biology
Evans DL,Connor MA,Moss LD,Lackay S,Leary JH,Krunkosky T,Jaso-Friedmann L
17-0453 was used in Flow cytometry/Cell sorting to identify and investigate the function of a H1x-like protein.
Wed Jul 01 00:00:00 EDT 2009
beta-Catenin expression in the bone marrow microenvironment is required for long-term maintenance of primitive hematopoietic cells.
Stem cells (Dayton, Ohio)
Nemeth MJ,Mak KK,Yang Y,Bodine DM
17-0453 was used in Flow cytometry to propose a model in which beta-catenin in the microenvironment is required noncell autonomously for long-term maintenance of hematopoietic progenitors.
Fri May 01 00:00:00 EDT 2009
Signal transduction inhibition of APCs diminishes th17 and Th1 responses in experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Skarica M,Wang T,McCadden E,Kardian D,Calabresi PA,Small D,Whartenby KA
17-0453 was used in Flow cytometry/Cell sorting to show that targeted inhibition of DCs in EAE-infected mice leads to a decrease in CNS infiltration of pathogenic Ag-specific T cells.
Wed Apr 01 00:00:00 EDT 2009
Chimeric NKG2D T cells require both T cell- and host-derived cytokine secretion and perforin expression to increase tumor antigen presentation and systemic immunity.
Journal of immunology (Baltimore, Md. : 1950)
Barber A,Sentman CL
17-0453 was used in Flow cytometry/Cell sorting to determine the mechanisms that chNKG2D T cells require to induce host immunity against ovarian tumours and which of the host immune cells are involved in tumour elimination.
Sat Aug 15 00:00:00 EDT 2009
IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response.
Blood
Rubinstein MP,Lind NA,Purton JF,Filippou P,Best JA,McGhee PA,Surh CD,Goldrath AW
17-0453 was used in Flow cytometry/Cell sorting to study IL-7 and IL-15 regulation of CD8+ T-cell subsets during contraction of the immune response.
Sat Nov 01 00:00:00 EDT 2008
Defective positive selection results in T cell lymphopenia and increased autoimmune diabetes in ADAP-deficient BDC2.5-C57BL/6 mice.
European journal of immunology
Zou L,Mendez F,Martin-Orozco N,Peterson EJ
17-0453 was used in Flow cytometry/Cell sorting to investigate the role of ADAP in a T cell-driven autoimmune response, showing that deficiency leads to defective positive selection in T cell lymphopenia and increased autoimmune diabetes.
Tue Apr 01 00:00:00 EDT 2008
Role for MyD88 signaling in murine gammaherpesvirus 68 latency.
Journal of virology
Gargano LM,Moser JM,Speck SH
17-0453 was used in Flow cytometry/Cell sorting to investigate the role of toll-like receptor signalling in the establishment and maintenance of murine gammaherpesvirus 68 latency in vivo, showing that MyD88 is important for the establishment of latency.
Tue Apr 01 00:00:00 EDT 2008
Sunlight triggers cutaneous lupus through a CSF-1-dependent mechanism in MRL-Fas(lpr) mice.
Journal of immunology (Baltimore, Md. : 1950)
Menke J,Hsu MY,Byrne KT,Lucas JA,Rabacal WA,Croker BP,Zong XH,Stanley ER,Kelley VR
17-0453 was used in Flow cytometry/Cell sorting to investigate the role of UVB in cutaneous lupus erythematosus, showing that UVB triggers it through a CSF-1-dependent, macrophage-mediated mechanism.
Sat Nov 15 00:00:00 EST 2008
Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice.
Journal of immunology (Baltimore, Md. : 1950)
Lucas JA,Menke J,Rabacal WA,Schoen FJ,Sharpe AH,Kelley VR
17-0453 was used in Flow cytometry/Cell sorting to compare kidney and systemic illness in PD-L1 null and PD-L1 intact mouse models of lupus.
Fri Aug 15 00:00:00 EDT 2008
Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.
Immunity
Siggs OM,Miosge LA,Yates AL,Kucharska EM,Sheahan D,Brdicka T,Weiss A,Liston A,Goodnow CC
17-0453 was used in Flow cytometry/Cell sorting to assess how a series of Zap70 variants, with step-wise decreases in T cell receptor (TCR) signalling, impact upon opposing TCR functions of immunity and tolerance.
Sat Dec 01 00:00:00 EST 2007
Dendritic cells prime natural killer cells by trans-presenting interleukin 15.
Immunity
Lucas M,Schachterle W,Oberle K,Aichele P,Diefenbach A
17-0453 was used in Flow cytometry/Cell sorting to study the in vivo role of dendritic cells for the priming of natural killer cells by trans-presenting interleukin 15.
Sun Apr 01 00:00:00 EDT 2007
An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2.
The Journal of experimental medicine
Cho JH,Boyman O,Kim HO,Hahm B,Rubinstein MP,Ramsey C,Kim DM,Surh CD,Sprent J
17-0453 was used in Flow cytometry/Cell sorting to describe a novel form of homeostatic proliferation that occurs when naive T cells encounter raised levels of IL-2 and IL-15 in vivo.
Mon Aug 06 00:00:00 EDT 2007
Presenilins regulate alphabeta T cell development by modulating TCR signaling.
The Journal of experimental medicine
Laky K,Fowlkes BJ
17-0453 was used in Flow cytometry/Cell sorting to suggest a model in which PS-dependent Notch signalling influences positive selection and the development of alphabeta T cells by modifying TCR signal transduction.
Mon Sep 03 00:00:00 EDT 2007
