Product References
Suppression of preadipocyte determination by SOX4 limits white adipocyte hyperplasia in obesity.
iScience
He T,Wang S,Li S,Shen H,Hou L,Liu Y,Wei Y,Xie F,Zhang Z,Zhao Z,Mo C,Guo H,Huang Q,Zhang R,Shen D,Li B
25-0453-82 was used in Flow Cytometry to highlight the importance of SOX4 in regulating the adipocyte hyperplasia in obesity.
Fri Apr 21 00:00:00 EDT 2023
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development.
Nature immunology
Scherer S,Oberle SG,Kanev K,Gerullis AK,Wu M,de Almeida GP,Puleston DJ,Baixauli F,Aly L,Greco A,Nizharadze T,Becker NB,Hoesslin MV,Donhauser LV,Berner J,Chu T,McNamara HA,Esencan Z,Roelli P,Wurmser C,Kleiter I,Vehreschild MJGT,Mayer CA,Knolle P,Klingenspor M,Fumagalli V,Iannacone M,Prlic M,Korn T,Pearce EL,Höfer T,Schulz AM,Zehn D
25-0453-82 was used in Flow cytometry/Cell sorting to show memory T cell precursors are resistant to pyrimidine starvation.
Wed Mar 01 00:00:00 EST 2023
Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis.
Science advances
Ma L,Tang Q,Gao X,Lee J,Lei R,Suzuki M,Zheng D,Ito K,Frenette PS,Dawlaty MM
Published figure using CD45.1 monoclonal antibody (Product # 25-0453-82) in Flow Cytometry
Fri Mar 04 00:00:00 EST 2022
Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis.
Science advances
Ma L,Tang Q,Gao X,Lee J,Lei R,Suzuki M,Zheng D,Ito K,Frenette PS,Dawlaty MM
Published figure using CD45.1 monoclonal antibody (Product # 25-0453-82) in Flow Cytometry
Fri Mar 04 00:00:00 EST 2022
Pharmacological perturbation of CXCL1 signaling alleviates neuropathogenesis in a model of HEVA71 infection.
Nature communications
Gunaseelan S,Ariffin MZ,Khanna S,Ooi MH,Perera D,Chu JJH,Chua JJE
25-0453-82 was used in Flow Cytometry to highlight the CXCL1-CXCR2 signaling pathway as a potential target against HFMD neuropathogenesis.
Wed Feb 16 00:00:00 EST 2022
The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow.
Cell stem cell
Zhang D,Gao X,Li H,Borger DK,Wei Q,Yang E,Xu C,Pinho S,Frenette PS
25-0453-82 was used in Flow cytometry/Cell sorting to reveal an intricate interplay between the microbiota, macrophages, and iron, and their essential roles in regulating critical HSC fate decisions under stress.
Thu Feb 03 00:00:00 EST 2022
IFN-γ-dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis.
Science advances
Garnier L,Pick R,Montorfani J,Sun M,Brighouse D,Liaudet N,Kammertoens T,Blankenstein T,Page N,Bernier-Latamani J,Tran NL,Petrova TV,Merkler D,Scheiermann C,Hugues S
25-0453-82 was used in Flow cytometry/Cell sorting to assess the impact of cytotoxic T cells on the local lymphatic vasculature and concomitant tumor dissemination during an antitumor response.
Fri Jun 10 00:00:00 EDT 2022
Gene replacement of α-globin with β-globin restores hemoglobin balance in β-thalassemia-derived hematopoietic stem and progenitor cells.
Nature medicine
Cromer MK,Camarena J,Martin RM,Lesch BJ,Vakulskas CA,Bode NM,Kurgan G,Collingwood MA,Rettig GR,Behlke MA,Lemgart VT,Zhang Y,Goyal A,Zhao F,Ponce E,Srifa W,Bak RO,Uchida N,Majeti R,Sheehan VA,Tisdale JF,Dever DP,Porteus MH
25-0453-82 was used in Flow Cytometry to demonstrate that edited HSPCs were capable of long-term and bilineage hematopoietic reconstitution in mice, establishing proof of concept for replacement of HBA1 with HBB as a novel therapeutic strategy for curing β-thalassemia.
Thu Apr 01 00:00:00 EDT 2021
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
Nature immunology
Rivas MA,Meydan C,Chin CR,Challman MF,Kim D,Bhinder B,Kloetgen A,Viny AD,Teater MR,McNally DR,Doane AS,Béguelin W,Fernández MTC,Shen H,Wang X,Levine RL,Chen Z,Tsirigos A,Elemento O,Mason CE,Melnick AM
Published figure using CD45.1 monoclonal antibody (Product # 25-0453-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.
Cell stem cell
Lv K,Gong C,Antony C,Han X,Ren JG,Donaghy R,Cheng Y,Pellegrino S,Warren AJ,Paralkar VR,Tong W
25-0453-82 was used in Flow cytometry/Cell sorting to reveal a role of the E3 ubiquitin ligase HectD1 in regulating HSC function via ribosome assembly and protein translation.
Thu Jul 01 00:00:00 EDT 2021
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
25-0453-82 was used in Flow Cytometry to understand the effects of age-related systemic factors on hematopoietic stem cells and their bone marrow niche.
Mon Jul 05 00:00:00 EDT 2021
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
25-0453-82 was used in Flow Cytometry to understand the effects of age-related systemic factors on hematopoietic stem cells and their bone marrow niche.
Mon Jul 05 00:00:00 EDT 2021
Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ.
Aging cell
Webb LMC,Fra-Bido S,Innocentin S,Matheson LS,Attaf N,Bignon A,Novarino J,Fazilleau N,Linterman MA
25-0453-82 was used in Flow Cytometry to show increased formation of Tfh precursors (pre-Tfh) but no associated increase in germinal centre (GC)-Tfh cells in aged mice, suggesting age-driven promotion of only early Tfh cell differentiation.
Fri Jan 01 00:00:00 EST 2021
Allergen-Specific Treg Cells Upregulated by Lung-Stage S. japonicum Infection Alleviates Allergic Airway Inflammation.
Frontiers in cell and developmental biology
Li Z,Zhang W,Luo F,Li J,Yang W,Zhu B,Wu Q,Wang X,Sun C,Xie Y,Xu B,Wang Z,Qian F,Chen J,Wan Y,Hu W
25-0453-82 was used in Flow Cytometry to investigate the protective effects of Schistosoma japonicum on allergic airway inflammation.
Sat Jun 26 00:00:00 EDT 2021
Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling.
Cell reports
Young IC,Wu B,Andricovich J,Chuang ST,Li R,Tzatsos A,Wu RC,Wu MY
Published figure using CD45.1 monoclonal antibody (Product # 25-0453-82) in Flow Cytometry
Tue Nov 23 00:00:00 EST 2021
Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies.
Cell reports
Seydoux E,Wan YH,Feng J,Wall A,Aljedani S,Homad LJ,MacCamy AJ,Weidle C,Gray MD,Brumage L,Taylor JJ,Pancera M,Stamatatos L,McGuire AT
Published figure using CD45.1 monoclonal antibody (Product # 25-0453-82) in Flow Cytometry
Tue May 04 00:00:00 EDT 2021
Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death.
Frontiers in immunology
Yang L,Chen W,Li L,Xiao Y,Fan S,Zhang Q,Xia T,Li M,Hong Y,Zhao T,Li Q,Liu WH,Xiao N
Published figure using CD45.1 monoclonal antibody (Product # 25-0453-82) in Flow Cytometry
Mon Dec 20 00:00:00 EST 2021
The concerted change in the distribution of cell cycle phases and zone composition in germinal centers is regulated by IL-21.
Nature communications
Zotos D,Quast I,Li-Wai-Suen CSN,McKenzie CI,Robinson MJ,Kan A,Smyth GK,Hodgkin PD,Tarlinton DM
25-0453-82 was used in Flow Cytometry to investigate regulation of cell cycle and germinal centres.
Thu Dec 09 00:00:00 EST 2021
TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling.
Cell reports
Agarwal P,Li H,Choi K,Hueneman K,He J,Welner RS,Starczynowski DT,Bhatia R
25-0453-82 was used in Flow Cytometry to find that TNF-α-mediated alterations in CML BM stromal niches enhance support of LSC maintenance and growth via CXCL1-CXCR2 signaling and that CXCR2 inhibition effectively depletes CML LSCs.
Tue Jul 13 00:00:00 EDT 2021
The TRACE-Seq method tracks recombination alleles and identifies clonal reconstitution dynamics of gene targeted human hematopoietic stem cells.
Nature communications
Sharma R,Dever DP,Lee CM,Azizi A,Pan Y,Camarena J,Köhnke T,Bao G,Porteus MH,Majeti R
25-0453-82 was used in Flow Cytometry to anticipate this methodology could potentially be used for HSPC clonal tracking of Cas9 RNP and AAV6-mediated gene targeting outcomes in translational and basic research settings.
Wed Jan 20 00:00:00 EST 2021
The TRACE-Seq method tracks recombination alleles and identifies clonal reconstitution dynamics of gene targeted human hematopoietic stem cells.
Nature communications
Sharma R,Dever DP,Lee CM,Azizi A,Pan Y,Camarena J,Köhnke T,Bao G,Porteus MH,Majeti R
25-0453-82 was used in Flow Cytometry to anticipate this methodology could potentially be used for HSPC clonal tracking of Cas9 RNP and AAV6-mediated gene targeting outcomes in translational and basic research settings.
Wed Jan 20 00:00:00 EST 2021
The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis.
Cell
Kitamoto S,Nagao-Kitamoto H,Jiao Y,Gillilland MG,Hayashi A,Imai J,Sugihara K,Miyoshi M,Brazil JC,Kuffa P,Hill BD,Rizvi SM,Wen F,Bishu S,Inohara N,Eaton KA,Nusrat A,Lei YL,Giannobile WV,Kamada N
25-0453-82 was used in Flow Cytometry to conclude that oral inflammation, such as periodontitis, exacerbates gut inflammation by supplying the gut with both colitogenic pathobionts and pathogenic T cells.
Thu Jul 23 00:00:00 EDT 2020
Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy.
Immunity
Milner JJ,Toma C,He Z,Kurd NS,Nguyen QP,McDonald B,Quezada L,Widjaja CE,Witherden DA,Crowl JT,Shaw LA,Yeo GW,Chang JT,Omilusik KD,Goldrath AW
25-0453 was used in Flow cytometry/Cell sorting to identify discrete lineages of intestinal antigen-specific CD8+ T cells, including a Blimp1hiId3lo tissue-resident effector cell population most prominent in the early phase of acute viral and bacterial infections and a molecularly distinct Blimp1loId3hi tissue-resident memory population that subsequently accumulated at later infection time points.
Tue May 19 00:00:00 EDT 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Published figure using CD45.1 monoclonal antibody (Product # 25-0453-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
Critical role of OX40 in drug-induced acute liver injury.
British journal of pharmacology
Zhang C,Jin H,Wang Y,Li C,Zhao X,Li Y,Shi W,Tian Y,Xu H,Tian D,Liu K,Jia J,Sun G,Zhang D
25-0453-82 was used in Flow Cytometry to show that OX40 is a key molecule that promotes both pro-inflammatory macrophage and CD4+ T-cell function, exacerbating paracetamol-induced liver injury.
Wed Jul 01 00:00:00 EDT 2020
RIPK3 and Caspase-1/11 Are Necessary for Optimal Antigen-Specific CD8 T Cell Response Elicited by Genetically Modified Listeria monocytogenes.
Frontiers in immunology
Rana A,de Almeida FC,Paico Montero HA,Gonzales Carazas MM,Bortoluci KR,Sad S,Amarante-Mendes GP
Published figure using CD45.1 monoclonal antibody (Product # 25-0453-82) in Flow Cytometry
Fri Mar 26 00:00:00 EDT 2021
Engineering monocyte/macrophage-specific glucocerebrosidase expression in human hematopoietic stem cells using genome editing.
Nature communications
Scharenberg SG,Poletto E,Lucot KL,Colella P,Sheikali A,Montine TJ,Porteus MH,Gomez-Ospina N
Published figure using CD45.1 monoclonal antibody (Product # 25-0453-82) in Flow Cytometry
Fri Jul 03 00:00:00 EDT 2020
Engineering monocyte/macrophage-specific glucocerebrosidase expression in human hematopoietic stem cells using genome editing.
Nature communications
Scharenberg SG,Poletto E,Lucot KL,Colella P,Sheikali A,Montine TJ,Porteus MH,Gomez-Ospina N
Published figure using CD45.1 monoclonal antibody (Product # 25-0453-82) in Flow Cytometry
Fri Jul 03 00:00:00 EDT 2020
TNFAIP3 Plays a Role in Aging of the Hematopoietic System.
Frontiers in immunology
Smith MA,Culver-Cochran AE,Adelman ER,Rhyasen GW,Ma A,Figueroa ME,Starczynowski DT
25-0453-82 was used in Flow Cytometry to find that the expression of A20 is significantly reduced in aged hematopoietic stem and progenitor cells (HSPC) as compared to young HSPC.
Wed Apr 28 00:00:00 EDT 2021
TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity.
Cell reports
Fuster JJ,Zuriaga MA,Zorita V,MacLauchlan S,Polackal MN,Viana-Huete V,Ferrer-Pérez A,Matesanz N,Herrero-Cervera A,Sano S,Cooper MA,González-Navarro H,Walsh K
25-0453 was used in Flow cytometry/Cell sorting to show that inactivating mutations in the epigenetic regulator TET2, which lead to clonal hematopoiesis, aggravate age- and obesity-related insulin resistance in mice.
Tue Oct 27 00:00:00 EDT 2020
Compartmentalized gut lymph node drainage dictates adaptive immune responses.
Nature
Esterházy D,Canesso MCC,Mesin L,Muller PA,de Castro TBR,Lockhart A,ElJalby M,Faria AMC,Mucida D
25-0453-82 was used in Flow Cytometry to show drainage of gut-draining lymph nodes can resolve conflicting tolerogenic and inflammatory intestinal responses by encouraging antigen targeting to specific gut segments.
Wed May 01 00:00:00 EDT 2019
The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4+ T Cell Peripheralization to Promote Effective Adaptive Immunity.
Immunity
Baptista AP,Gola A,Huang Y,Milanez-Almeida P,Torabi-Parizi P,Urban JF,Shapiro VS,Gerner MY,Germain RN
25-0453 was used in Flow cytometry/Cell sorting to demonstrate evolutionary selection for distinct niches within the LN that promote cellular responses, emphasizing the critical link between fine-grained tissue organization and host defense.
Tue May 21 00:00:00 EDT 2019
CD8+ T cells induce cachexia during chronic viral infection.
Nature immunology
Baazim H,Schweiger M,Moschinger M,Xu H,Scherer T,Popa A,Gallage S,Ali A,Khamina K,Kosack L,Vilagos B,Smyth M,Lercher A,Friske J,Merkler D,Aderem A,Helbich TH,Heikenwälder M,Lang PA,Zechner R,Bergthaler A
25-0453-82 was used in Flow Cytometry to identify the role for CD8+ T cells in infection-associated cachexia.
Sat Jun 01 00:00:00 EDT 2019
Regulatory T cells mediate specific suppression by depleting peptide-MHC class II from dendritic cells.
Nature immunology
Akkaya B,Oya Y,Akkaya M,Al Souz J,Holstein AH,Kamenyeva O,Kabat J,Matsumura R,Dorward DW,Glass DD,Shevach EM
25-0453-82 was used in Flow Cytometry to study whether pathways similar to the multiple suppressive mechansims triggered in vitro by T cell antigen receptor activated regulatory T cells exist in vivo.
Fri Feb 01 00:00:00 EST 2019
Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem Cells.
Cell stem cell
Agarwal P,Isringhausen S,Li H,Paterson AJ,He J,Gomariz Á,Nagasawa T,Nombela-Arrieta C,Bhatia R
25-0453-82 was used in Flow Cytometry to highlight a critical role of niche-specific effects of Cxcl12 expression in maintaining quiescence of TKI-resistant LSC populations.
Thu May 02 00:00:00 EDT 2019
SIRT1 regulates metabolism and leukemogenic potential in CML stem cells.
The Journal of clinical investigation
Abraham A,Qiu S,Chacko BK,Li H,Paterson A,He J,Agarwal P,Shah M,Welner R,Darley-Usmar VM,Bhatia R
25-0453 was used in Flow cytometry/Cell sorting to demonstrate an important role for SIRT1 in leukemia development.
Mon Jun 10 00:00:00 EDT 2019
Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response.
Science translational medicine
Sharon D,Cathelin S,Mirali S,Di Trani JM,Yanofsky DJ,Keon KA,Rubinstein JL,Schimmer AD,Ketela T,Chan SM
25-0453-82 was used in Flow cytometry/Cell sorting to investigate if inactivation of genes involved in mitochondrial translation restores sensitivity to venetoclax in resistant acute myeloid leukemia cells.
Wed Oct 30 00:00:00 EDT 2019
Highly efficient editing of the β-globin gene in patient-derived hematopoietic stem and progenitor cells to treat sickle cell disease.
Nucleic acids research
Park SH,Lee CM,Dever DP,Davis TH,Camarena J,Srifa W,Zhang Y,Paikari A,Chang AK,Porteus MH,Sheehan VA,Bao G
25-0453-82 was used in Flow Cytometry to demonstrate efficient gene correction of the sickle mutation in both peripheral blood and bone marrow-derived SCD HSPCs, a significant reduction in sickling of red blood cells, engraftment of gene-edited SCD HSPCs in vivo and the importance of reducing off-target effects; all are essential for moving genome editing based SCD treatment into clinical practice.
Thu Sep 05 00:00:00 EDT 2019
The Sympathetic Nervous System Mitigates CNS Autoimmunity via β2-Adrenergic Receptor Signaling in Immune Cells.
Cell reports
Araujo LP,Maricato JT,Guereschi MG,Takenaka MC,Nascimento VM,de Melo FM,Quintana FJ,Brum PC,Basso AS
25-0453-82 was used in Flow Cytometry to uncover a suppressive role for the SNS in CNS autoimmunity while they identify potential targets for therapeutic intervention.
Tue Sep 17 00:00:00 EDT 2019
Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells.
Cell reports
Chen C,Yu W,Tober J,Gao P,He B,Lee K,Trieu T,Blobel GA,Speck NA,Tan K
25-0453 was used in Flow cytometry/Cell sorting to find that chromosomal compartments and topologically associating domains (TADs) are largely conserved between fetal and adult HSCs.
Tue Dec 17 00:00:00 EST 2019
Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation.
Cell reports
Garg G,Muschaweckh A,Moreno H,Vasanthakumar A,Floess S,Lepennetier G,Oellinger R,Zhan Y,Regen T,Hiltensperger M,Peter C,Aly L,Knier B,Palam LR,Kapur R,Kaplan MH,Waisman A,Rad R,Schotta G,Huehn J,Kallies A,Korn T
25-0453 was used in Flow cytometry/Cell sorting to identify a Blimp1-dependent pathway that preserves Treg cell stability in inflamed non-lymphoid tissues.
Tue Feb 12 00:00:00 EST 2019
Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis.
Cell reports
Pyaram K,Kumar A,Kim YH,Noel S,Reddy SP,Rabb H,Chang CH
25-0453 was used in Flow cytometry/Cell sorting to report that T cellspecific deletion of Keap1 results in defective development and reduced numbers of invariant natural killer T (NKT) cells in the thymus and the peripheral organs in a cell-intrinsic manner.
Tue Apr 16 00:00:00 EDT 2019
Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia.
Nature medicine
Zhang B,Nguyen LXT,Li L,Zhao D,Kumar B,Wu H,Lin A,Pellicano F,Hopcroft L,Su YL,Copland M,Holyoake TL,Kuo CJ,Bhatia R,Snyder DS,Ali H,Stein AS,Brewer C,Wang H,McDonald T,Swiderski P,Troadec E,Chen CC,Dorrance A,Pullarkat V,Yuan YC,Perrotti D,Carlesso N,Forman SJ,Kortylewski M,Kuo YH,Marcucci G
25-0453 was used in Flow cytometry/Cell sorting to demonstrate how bone marrow endothelial cells supply miR-126 to leukemia stem cells in chronic myelogenous leukemia which modulates their quiescence and self-renewal.
Tue May 01 00:00:00 EDT 2018
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using CD45.1 monoclonal antibody (Product # 25-0453-82) in Flow Cytometry
Thu Jan 25 00:00:00 EST 2018
CRISPR/Cas9 genome editing in human hematopoietic stem cells.
Nature protocols
Bak RO,Dever DP,Porteus MH
25-0453 was used in Flow cytometry/Cell sorting to contribute to a protocol for the production, enrichment, and in vitro and in vivo analyses of HR-targeted hematopoietic stem cells.
Thu Feb 01 00:00:00 EST 2018
The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice.
eLife
Schmidt K,Zhang Q,Tasdogan A,Petzold A,Dahl A,Arneth BM,Slany R,Fehling HJ,Kranz A,Stewart AF,Anastassiadis K
Published figure using CD45.1 monoclonal antibody (Product # 25-0453-82) in Flow Cytometry
Tue Jun 19 00:00:00 EDT 2018
An immune cell spray (ICS) formulation allows for the delivery of functional monocyte/macrophages.
Scientific reports
Beneke V,Küster F,Neehus AL,Hesse C,Lopez-Rodriguez E,Haake K,Rafiei Hashtchin A,Schott JW,Walter D,Braun A,Wolkers WF,Ackermann M,Lachmann N
Published figure using CD45.1 monoclonal antibody (Product # 25-0453-82) in Flow Cytometry
Fri Nov 02 00:00:00 EDT 2018
The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia.
Nature medicine
Fenouille N,Bassil CF,Ben-Sahra I,Benajiba L,Alexe G,Ramos A,Pikman Y,Conway AS,Burgess MR,Li Q,Luciano F,Auberger P,Galinsky I,DeAngelo DJ,Stone RM,Zhang Y,Perkins AS,Shannon K,Hemann MT,Puissant A,Stegmaier K
25-0453 was used in Flow cytometry/Cell sorting to investigate the effect of MECOM on cellular metabolism.
Wed Mar 01 00:00:00 EST 2017
Autophagy maintains the metabolism and function of young and old stem cells.
Nature
Ho TT,Warr MR,Adelman ER,Lansinger OM,Flach J,Verovskaya EV,Figueroa ME,Passegué E
25-0453 was used in Flow cytometry/Cell sorting to demonstrate an essential function for autophagy in removing activated mitochondria and controlling oxidative metabolism, thereby maintaining HSC stemness and regenerative potential.
Thu Mar 09 00:00:00 EST 2017
Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.
Cell host & microbe
Zhu F,Willette-Brown J,Song NY,Lomada D,Song Y,Xue L,Gray Z,Zhao Z,Davis SR,Sun Z,Zhang P,Wu X,Zhan Q,Richie ER,Hu Y
25-0453 was used in Flow cytometry/Cell sorting to demonstrate that autoreactive T-cells and chronic fungal infection, fostered by inflammation and epithelial injury, promote esophageal squamous cell carcinoma development.
Wed Apr 12 00:00:00 EDT 2017
Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.
Nature immunology
Fang J,Bolanos LC,Choi K,Liu X,Christie S,Akunuru S,Kumar R,Wang D,Chen X,Greis KD,Stoilov P,Filippi MD,Maciejewski JP,Garcia-Manero G,Weirauch MT,Salomonis N,Geiger H,Zheng Y,Starczynowski DT
25-0453 was used in Flow cytometry/Cell sorting to examine the significance of ubiquitin signalling in coordinating RNA processing by Toll-like receptor pathways during an immune response and in premalignant haematologic diseases.
Wed Feb 01 00:00:00 EST 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
Published figure using CD45.1 monoclonal antibody (Product # 25-0453-82) in Flow Cytometry
Mon Jun 05 00:00:00 EDT 2017
Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.
The Journal of experimental medicine
Thomas DC,Clare S,Sowerby JM,Pardo M,Juss JK,Goulding DA,van der Weyden L,Storisteanu D,Prakash A,Espéli M,Flint S,Lee JC,Hoenderdos K,Kane L,Harcourt K,Mukhopadhyay S,Umrania Y,Antrobus R,Nathan JA,Adams DJ,Bateman A,Choudhary JS,Lyons PA,Condliffe AM,Chilvers ER,Dougan G,Smith KG
25-0453 was used in Flow cytometry/Cell sorting to describe the key role of the previously uncharacterised protein Eros in host defence.
Mon Apr 03 00:00:00 EDT 2017
Generation and use of a humanized bone-marrow-ossicle niche for hematopoietic xenotransplantation into mice.
Nature protocols
Reinisch A,Hernandez DC,Schallmoser K,Majeti R
25-0453 was used in Flow cytometry/Cell sorting to describe a robust and reproducible in vivo methodology for the study of normal and malignant human hematopoiesis in a more physiologic setting.
Sun Oct 01 00:00:00 EDT 2017
Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.
Proceedings of the National Academy of Sciences of the United States of America
Pishesha N,Bilate AM,Wibowo MC,Huang NJ,Li Z,Deshycka R,Bousbaine D,Li H,Patterson HC,Dougan SK,Maruyama T,Lodish HF,Ploegh HL
25045382 was used in flow cytometry to investigate the use of red blood cells expressing disease-associated autoantigenas a means of inducing antigen-specific tolerance
Tue Mar 21 00:00:00 EDT 2017
CD4+ Th2 cells are directly regulated by IL-10 during allergic airway inflammation.
Mucosal immunology
Coomes SM,Kannan Y,Pelly VS,Entwistle LJ,Guidi R,Perez-Lloret J,Nikolov N,Müller W,Wilson MS
25-0453 was used in Flow cytometry/Cell sorting to identify that pathogenic Th2 cells are an important direct target of IL-10 and an insight into IL-10 mediated regualation of allergic airway inflammation.
Sun Jan 01 00:00:00 EST 2017
Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells.
Nature communications
Downs-Canner S,Berkey S,Delgoffe GM,Edwards RP,Curiel T,Odunsi K,Bartlett DL,Obermajer N
25-0453 was used in Flow cytometry/Cell sorting to demonstrate the tumour-associated conversion of Th17 cells to Treg cells and identify transdifferentiation-associated markers.
Tue Mar 14 00:00:00 EDT 2017
Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data.
Nature communications
Sinha S,Thomas D,Chan S,Gao Y,Brunen D,Torabi D,Reinisch A,Hernandez D,Chan A,Rankin EB,Bernards R,Majeti R,Dill DL
25-0453 was used in Flow cytometry/Cell sorting to demonstrate that MiSL can accelerate precision oncology by identifying mutation-specific targets and biomarkers.
Wed May 31 00:00:00 EDT 2017
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Cell
Damgaard RB,Walker JA,Marco-Casanova P,Morgan NV,Titheradge HL,Elliott PR,McHale D,Maher ER,McKenzie ANJ,Komander D
Published figure using CD45.1 monoclonal antibody (Product # 25-0453-82) in Flow Cytometry
Thu Aug 25 00:00:00 EDT 2016
Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.
Nature cell biology
Pietras EM,Mirantes-Barbeito C,Fong S,Loeffler D,Kovtonyuk LV,Zhang S,Lakshminarasimhan R,Chin CP,Techner JM,Will B,Nerlov C,Steidl U,Manz MG,Schroeder T,Passegué E
25-0453 was used in Flow cytometry/Cell sorting to identify a critical regulatory circuit that tailors HSC responses to acute needs, and is likely to underlie deregulated blood homeostasis in chronic inflammation conditions.
Wed Jun 01 00:00:00 EDT 2016
Triggering the adaptive immune system with commensal gut bacteria protects against insulin resistance and dysglycemia.
Molecular metabolism
Pomié C,Blasco-Baque V,Klopp P,Nicolas S,Waget A,Loubières P,Azalbert V,Puel A,Lopez F,Dray C,Valet P,Lelouvier B,Servant F,Courtney M,Amar J,Burcelin R,Garidou L
25-0453 was used in Flow cytometry/Cell sorting to investigate how glycemia and insulin sensitivity can be regulated by triggering the adaptive immunity to microbiota interaction.
Wed Jun 01 00:00:00 EDT 2016
Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Song Y,Kumar V,Wei HX,Qiu J,Stanley P
25-0453 was used in Flow cytometry/Cell sorting to investigate the roles for maniac fringe (MFNG) and radical fringe (RFNG) in T cell development, RFNG in B cell development, and Fringes in T and B cell activation, showing that they promote T and B cell development.
Fri Jan 01 00:00:00 EST 2016
Flt3 Ligand Regulates the Development of Innate Lymphoid Cells in Fetal and Adult Mice.
Journal of immunology (Baltimore, Md. : 1950)
Baerenwaldt A,von Burg N,Kreuzaler M,Sitte S,Horvath E,Peter A,Voehringer D,Rolink AG,Finke D
25-0453 was used in Flow cytometry/Cell sorting to investigate the role of the Flt3 ligand in the development and regulation of innate lymphoid cells in fetal and adult mice.
Tue Mar 15 00:00:00 EDT 2016
CD137 Agonist Therapy Can Reprogram Regulatory T Cells into Cytotoxic CD4+ T Cells with Antitumor Activity.
Journal of immunology (Baltimore, Md. : 1950)
Akhmetzyanova I,Zelinskyy G,Littwitz-Salomon E,Malyshkina A,Dietze KK,Streeck H,Brandau S,Dittmer U
25-0453 was used in Flow cytometry/Cell sorting to study the mechanisms of immunological tumour control by CD4(+) T cells in the course of CD137 agonist immunotherapy in the absence of a CD8 T cell response.
Fri Jan 01 00:00:00 EST 2016
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.
Stem cell reports
Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N
25-0453 was used in Flow cytometry/Cell sorting to describe a protocol to obtain mature and functional MΦ from healthy as well as disease-specific murine iPSCs.
Tue Aug 09 00:00:00 EDT 2016
CCR7 Controls Thymus Recirculation, but Not Production and Emigration, of Foxp3(+) T Cells.
Cell reports
Cowan JE,McCarthy NI,Anderson G
25-0453 was used in Flow cytometry/Cell sorting to investigate CCR7 and Rag2pGFP levels during Treg development, showing that CCR7 controls thymus recirculation, but not production and emigration, of Foxp3(+) T cells.
Tue Feb 09 00:00:00 EST 2016
The non-canonical Wnt receptor Ryk regulates hematopoietic stem cell repopulation in part by controlling proliferation and apoptosis.
Cell death & disease
Famili F,Perez LG,Naber BA,Noordermeer JN,Fradkin LG,Staal FJ
25-0453 was used in Flow cytometry/Cell sorting to investigate the role of the non-canonical Wnt receptor Ryk in haematopoiesis and lymphoid development.
Thu Nov 24 00:00:00 EST 2016
Switching CAR T cells on and off: a novel modular platform for retargeting of T cells to AML blasts.
Blood cancer journal
Cartellieri M,Feldmann A,Koristka S,Arndt C,Loff S,Ehninger A,von Bonin M,Bejestani EP,Ehninger G,Bachmann MP
25-0453 was used in Flow cytometry/Cell sorting to describe a novel modular universal platform for retargeting of T cells to AML blasts, via switching CD19-specific chimeric antigen receptor engineered T cells on or off.
Fri Aug 12 00:00:00 EDT 2016
Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity.
PloS one
Jonas BA,Johnson C,Gratzinger D,Majeti R
25-0453 was used in Flow cytometry/Cell sorting to report several new t-AML/MDS mouse models that could potentially be used to further define disease pathogenesis and test novel therapeutics.
Wed Jul 26 00:00:00 EDT 2017
Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia.
Nature medicine
Chan SM,Thomas D,Corces-Zimmerman MR,Xavy S,Rastogi S,Hong WJ,Zhao F,Medeiros BC,Tyvoll DA,Majeti R
25-0453 was used in Flow cytometry/Cell sorting to provide evidence that IDH1/2 mutation status may identify AML patients that are likely to respond to pharmacologic BCL-2 inhibition.
Sun Feb 01 00:00:00 EST 2015
miR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a.
Blood
Hu W,Dooley J,Chung SS,Chandramohan D,Cimmino L,Mukherjee S,Mason CE,de Strooper B,Liston A,Park CY
25-0453 was used in Flow cytometry/Cell sorting to demonstrate that miR-29a is critical for maintaining HSC function through its negative regulation of Dnmt3a.
Thu Apr 02 00:00:00 EDT 2015
Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors.
The Journal of clinical investigation
Henry CJ,Casás-Selves M,Kim J,Zaberezhnyy V,Aghili L,Daniel AE,Jimenez L,Azam T,McNamee EN,Clambey ET,Klawitter J,Serkova NJ,Tan AC,Dinarello CA,DeGregori J
25-0453 was used in Flow cytometry/Cell sorting to conclude that chronic inflammatory microenvironments in old age lead to reductions in the fitness of B cell progenitor populations.
Tue Dec 01 00:00:00 EST 2015
MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.
Proceedings of the National Academy of Sciences of the United States of America
Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D
Published figure using CD45.1 monoclonal antibody (Product # 25-0453-82) in Flow Cytometry
Tue Dec 29 00:00:00 EST 2015
IFNγ and IL-12 Restrict Th2 Responses during Helminth/Plasmodium Co-Infection and Promote IFNγ from Th2 Cells.
PLoS pathogens
Coomes SM,Pelly VS,Kannan Y,Okoye IS,Czieso S,Entwistle LJ,Perez-Lloret J,Nikolov N,Potocnik AJ,Biró J,Langhorne J,Wilson MS
25-0453 was used in Flow cytometry/Cell sorting to show that co-infection with Plasmodium spp. may contribute to the chronicity of helminth infection by reducing the frequency of anti-helminth Th2 cells.
Wed Jul 01 00:00:00 EDT 2015
Altered lymph node composition in diphtheria toxin receptor-based mouse models to ablate dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
van Blijswijk J,Schraml BU,Rogers NC,Whitney PG,Zelenay S,Acton SE,Reis e Sousa C
25-0453 was used in Flow cytometry/Cell sorting to report that mice in which DTR is expressed on DCs display lymph node hypocellularity and reduced frequency of DCs in the same organs.
Thu Jan 01 00:00:00 EST 2015
Leptin receptor signaling in T cells is required for Th17 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Reis BS,Lee K,Fanok MH,Mascaraque C,Amoury M,Cohn LB,Rogoz A,Dallner OS,Moraes-Vieira PM,Domingos AI,Mucida D
25-0453 was used in Flow cytometry/Cell sorting to show that leptin receptor signalling in T cells is required for Th17 differentiation.
Mon Jun 01 00:00:00 EDT 2015
Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation.
BioMed research international
Tejón G,Manríquez V,De Calisto J,Flores-Santibáñez F,Hidalgo Y,Crisóstomo N,Fernández D,Sauma D,Mora JR,Bono MR,Rosemblatt M
25-0453 was used in Flow cytometry/Cell sorting to study the contribution of different factors to the reprogramming of iTregs into IL-17-producing cells, showing that vitamin A impairs reprogramming during intestinal inflammation.
Fri Sep 02 00:00:00 EDT 2016
A 3-D enteroid-based model to study T-cell and epithelial cell interaction.
Journal of immunological methods
Rogoz A,Reis BS,Karssemeijer RA,Mucida D
25-0453 was used in Flow cytometry/Cell sorting to describe a novel method for studying specific pathways in intestinal epithelial cell or immune cell compartments.
Mon Jun 01 00:00:00 EDT 2015
Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis.
Nature communications
Xue J,Sharma V,Hsieh MH,Chawla A,Murali R,Pandol SJ,Habtezion A
Published figure using CD45.1 monoclonal antibody (Product # 25-0453-82) in Flow Cytometry
Mon May 18 00:00:00 EDT 2015
Pre-Clinical Development of a Humanized Anti-CD47 Antibody with Anti-Cancer Therapeutic Potential.
PloS one
Liu J,Wang L,Zhao F,Tseng S,Narayanan C,Shura L,Willingham S,Howard M,Prohaska S,Volkmer J,Chao M,Weissman IL,Majeti R
25-0453 was used in Flow cytometry/Cell sorting to show that humanized 5F9 antibody induces potent macrophage-mediated phagocytosis of primary human AML cells in vitro and human AML in vivo.
Tue May 31 00:00:00 EDT 2016
Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion.
Nature medicine
Bruns I,Lucas D,Pinho S,Ahmed J,Lambert MP,Kunisaki Y,Scheiermann C,Schiff L,Poncz M,Bergman A,Frenette PS
25-0453 was used in Flow cytometry/Cell sorting to indicate that a terminally differentiated cell type derived from HSCs contributes to the HSC niche, directly regulating HSC behavior.
Sat Nov 01 00:00:00 EDT 2014
Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages.
Cell
Haldar M,Kohyama M,So AY,Kc W,Wu X,Briseño CG,Satpathy AT,Kretzer NM,Arase H,Rajasekaran NS,Wang L,Egawa T,Igarashi K,Baltimore D,Murphy TL,Murphy KM
Published figure using CD45.1 monoclonal antibody (Product # 25-0453-82) in Flow Cytometry
Thu Mar 13 00:00:00 EDT 2014
Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation.
Nature genetics
Lane AA,Chapuy B,Lin CY,Tivey T,Li H,Townsend EC,van Bodegom D,Day TA,Wu SC,Liu H,Yoda A,Alexe G,Schinzel AC,Sullivan TJ,Malinge S,Taylor JE,Stegmaier K,Jaffe JD,Bustin M,te Kronnie G,Izraeli S,Harris MH,Stevenson KE,Neuberg D,Silverman LB,Sallan SE,Bradner JE,Hahn WC,Crispino JD,Pellman D,Weinstock DM
25-0453 was used in Flow cytometry/Cell sorting to show that germline triplication of only 31 genes orthologous to human chromosome 21q22 confers mouse progenitor B cell self renew in vitro.
Sun Jun 01 00:00:00 EDT 2014
Collective nitric oxide production provides tissue-wide immunity during Leishmania infection.
The Journal of clinical investigation
Olekhnovitch R,Ryffel B,Müller AJ,Bousso P
25-0453 was used in Flow cytometry/Cell sorting to investigate the contribution of cell-intrinsic and cell-extrinsic nitric oxide activity on the control of Leishmania major infection.
Tue Apr 01 00:00:00 EDT 2014
WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.
The Journal of experimental medicine
Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z
Published figure using CD45.1 monoclonal antibody (Product # 25-0453-82) in Flow Cytometry
Mon Sep 22 00:00:00 EDT 2014
Establishment of murine gammaherpesvirus latency in B cells is not a stochastic event.
PLoS pathogens
Decalf J,Godinho-Silva C,Fontinha D,Marques S,Simas JP
25-0453 was used in Flow cytometry/Cell sorting to study whether B cell receptor specificity plays a role in B cell susceptibility to Murid γ-herpesvirus-4 latency.
Tue Jul 01 00:00:00 EDT 2014
E and Id proteins influence invariant NKT cell sublineage differentiation and proliferation.
Journal of immunology (Baltimore, Md. : 1950)
D'Cruz LM,Stradner MH,Yang CY,Goldrath AW
25-0453 was used in Flow cytometry/Cell sorting to investigate the mechanism by which E and Id proteins control the development of invariant NKT sublineages after positive selection.
Sat Mar 01 00:00:00 EST 2014
A novel ex vivo isolation and expansion procedure for chimeric antigen receptor engrafted human T cells.
PloS one
Cartellieri M,Koristka S,Arndt C,Feldmann A,Stamova S,von Bonin M,Töpfer K,Krüger T,Geib M,Michalk I,Temme A,Bornhäuser M,Lindemann D,Ehninger G,Bachmann MP
25-0453 was used in Flow cytometry/Cell sorting to assess the effectiveness of a novel peptide epitope to trigger the expansion of specific populations of T cells.
Thu Jan 29 00:00:00 EST 2015
Themis sets the signal threshold for positive and negative selection in T-cell development.
Nature
Fu G,Casas J,Rigaud S,Rybakin V,Lambolez F,Brzostek J,Hoerter JA,Paster W,Acuto O,Cheroutre H,Sauer K,Gascoigne NR
25-0453 was used in Flow cytometry/Cell sorting to show that the T-cell-specific protein Themis can specifically attenuate TCR signal strength via SHP1 recruitment and activation in response to low-affinity TCR engagement.
Thu Dec 19 00:00:00 EST 2013
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.
Nature immunology
Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D
25-0453 was used in Flow cytometry/Cell sorting to demonstrate plasticity in the CD4(+) T cell lineage that allows chronic exposure to luminal antigens without pathological inflammation.
Fri Mar 01 00:00:00 EST 2013
Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice.
Blood
Doyle AD,Jacobsen EA,Ochkur SI,McGarry MP,Shim KG,Nguyen DT,Protheroe C,Colbert D,Kloeber J,Neely J,Shim KP,Dyer KD,Rosenberg HF,Lee JJ,Lee NA
25-0453 was used in Flow cytometry/Cell sorting to investigate the contributions of the granule proteins MBP-1 and EPX to eosinophil activity using double knockout mice.
Thu Aug 01 00:00:00 EDT 2013
Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes.
EMBO molecular medicine
Soehnlein O,Drechsler M,Döring Y,Lievens D,Hartwig H,Kemmerich K,Ortega-Gómez A,Mandl M,Vijayan S,Projahn D,Garlichs CD,Koenen RR,Hristov M,Lutgens E,Zernecke A,Weber C
25-0453 was used in Flow cytometry/Cell sorting to investigate the differential role of classical and non-classical leukocytes in atheroprogression under high-fat diet, showing that CXCL1 and CCR1/CCR5 are important in the mobilisation and recruitment of classical monocytes in atheroprogression.
Fri Mar 01 00:00:00 EST 2013
Therapeutic evaluation of ex vivo-generated versus natural regulatory T-cells in a mouse model of chronic gut inflammation.
Inflammatory bowel diseases
Karlsson F,Martinez NE,Gray L,Zhang S,Tsunoda I,Grisham MB
25-0453 was used in Flow cytometry/Cell sorting to study the effect of ex vivo-generated and isolated Treg cells on a mouse model of chronic colitis, showing that ex-vivo Tregs were more potent at attenuating colitis, likely due to the associated decrease in IL-6 and IL-17A expression in the colon.
Tue Oct 01 00:00:00 EDT 2013
Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells.
Development (Cambridge, England)
Tober J,Yzaguirre AD,Piwarzyk E,Speck NA
25-0453 was used in Flow cytometry/Cell sorting to study how the requirements for Runx1 in erythroid/myeloid progenitors and hematopoietic stem cell formation are temporally distinct.
Sun Sep 01 00:00:00 EDT 2013
Efficiently stimulated adult microglia cross-prime naive CD8+ T cells injected in the brain.
European journal of immunology
Jarry U,Jeannin P,Pineau L,Donnou S,Delneste Y,Couez D
25-0453 was used in Flow cytometry/Cell sorting to study whether microglia are able to cross-present antigen to naive CD8(+) T cells within the brain microenvironment in vivo.
Wed May 01 00:00:00 EDT 2013
Arrayed lentiviral barcoding for quantification analysis of hematopoietic dynamics.
Stem cells (Dayton, Ohio)
Grosselin J,Sii-Felice K,Payen E,Chretien S,Tronik-Le Roux D,Leboulch P
Published figure using CD45.1 monoclonal antibody (Product # 25-0453-82) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2013
Analyses of microglia effector function using CX3CR1-GFP knock-in mice.
Methods in molecular biology (Clifton, N.J.)
Garcia JA,Cardona SM,Cardona AE
25-0453 was used in Flow cytometry/Cell sorting to analyse the role of CX3CR1 in central nervous system inflammation in bone marrow radiation chimeric mice.
Thu Jan 30 00:00:00 EST 2014
Control of murine Ly6C(high) monocyte traffic and immunosuppressive activities by atypical chemokine receptor D6.
Blood
Savino B,Castor MG,Caronni N,Sarukhan A,Anselmo A,Buracchi C,Benvenuti F,Pinho V,Teixeira MM,Mantovani A,Locati M,Bonecchi R
25-0453 was used in Flow cytometry/Cell sorting to study how control of CCR2 ligands by D6 regulates the traffic of Ly6C(high) monocytes and controls their immunosuppressive potential.
Thu May 31 00:00:00 EDT 2012
Thymus-autonomous T cell development in the absence of progenitor import.
The Journal of experimental medicine
Martins VC,Ruggiero E,Schlenner SM,Madan V,Schmidt M,Fink PJ,von Kalle C,Rodewald HR
25-0453 was used in Flow cytometry/Cell sorting to characterise the previously unrecognised capacity of the thymus to sustain T cell development during bone marrow progenitor deprivation.
Mon Jul 30 00:00:00 EDT 2012
The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood.
Journal of immunology (Baltimore, Md. : 1950)
Mizutani M,Pino PA,Saederup N,Charo IF,Ransohoff RM,Cardona AE
25-0453 was used in Flow cytometry/Cell sorting to study CX3CR1 and CCR2 transcription unit activation in reporter mice to infer how myeloid lineages differentiate during development.
Sun Jan 01 00:00:00 EST 2012
In vitro Ag Cross-presentation and in vivo Ag Cross-presentation by Dendritic Cells in the Mouse.
Bio-protocol
Ghosh M,Shapiro LH
Published figure using CD45.1 monoclonal antibody (Product # 25-0453-82) in Flow Cytometry
Thu Dec 20 00:00:00 EST 2012
Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response.
Blood
Gardam S,Turner VM,Anderton H,Limaye S,Basten A,Koentgen F,Vaux DL,Silke J,Brink R
25-0453 was used in Flow cytometry/Cell sorting to investigate the roles of cIAP1 and cIAP2 in controlling B-cell physiology.
Thu Apr 14 00:00:00 EDT 2011
Hydrodynamic delivery of human IL-15 cDNA increases murine natural killer cell recovery after syngeneic bone marrow transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Barao I,Alvarez M,Redelman D,Weiss JM,Ortaldo JR,Wiltrout RH,Murphy WJ
25-0453 was used in Flow cytometry/Cell sorting to highlight cytokine gene transfer-based methods as a potential platform for natural killer cell recovery after bone marrow transplantation in mice.
Thu Dec 01 00:00:00 EST 2011
Vitamin A deficiency impairs vaccine-elicited gastrointestinal immunity.
Journal of immunology (Baltimore, Md. : 1950)
Kaufman DR,De Calisto J,Simmons NL,Cruz AN,Villablanca EJ,Mora JR,Barouch DH
25-0453 was used in Flow cytometry/Cell sorting to suggest that oral vitamin A supplementation may be important for optimizing the success of vaccines against HIV-1 and other mucosal pathogens in the developing world.
Mon Aug 15 00:00:00 EDT 2011
EBI2 operates independently of but in cooperation with CXCR5 and CCR7 to direct B cell migration and organization in follicles and the germinal center.
Journal of immunology (Baltimore, Md. : 1950)
Gatto D,Wood K,Brink R
25-0453 was used in Flow cytometry/Cell sorting to show EBI2-mediated chemotaxis provides a third dimension to B cell migration that balances and integrates with the inputs from CXCR5 and CCR7 to determine B cell positioning.
Tue Nov 01 00:00:00 EDT 2011
Notch3 is dispensable for thymocyte β-selection and Notch1-induced T cell leukemogenesis.
PloS one
Suliman S,Tan J,Xu K,Kousis PC,Kowalski PE,Chang G,Egan SE,Guidos C
25-0453 was used in Flow cytometry/Cell sorting to assess the essentiality of Notch3 signalling for T cell development and leukaemogenesis.
Tue Feb 28 00:00:00 EST 2012
Targeting of B and T lymphocyte associated (BTLA) prevents graft-versus-host disease without global immunosuppression.
The Journal of experimental medicine
Albring JC,Sandau MM,Rapaport AS,Edelson BT,Satpathy A,Mashayekhi M,Lathrop SK,Hsieh CS,Stelljes M,Colonna M,Murphy TL,Murphy KM
25-0453 was used in Flow cytometry/Cell sorting to show that administration of a nondepleting, monoclonal antibody permanently prevented graft-versus-host-disease when administered at the time of the transplant.
Mon Nov 22 00:00:00 EST 2010
Route of adenovirus-based HIV-1 vaccine delivery impacts the phenotype and trafficking of vaccine-elicited CD8+ T lymphocytes.
Journal of virology
Kaufman DR,Bivas-Benita M,Simmons NL,Miller D,Barouch DH
25-0453 was used in Flow cytometry/Cell sorting to indicate that the anatomic microenvironment of antigen expression critically impacts the phenotype and trafficking of antigen-specific CD8(+) T lymphocytes.
Tue Jun 01 00:00:00 EDT 2010
CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation.
The Journal of experimental medicine
Auffray C,Fogg DK,Narni-Mancinelli E,Senechal B,Trouillet C,Saederup N,Leemput J,Bigot K,Campisi L,Abitbol M,Molina T,Charo I,Hume DA,Cumano A,Lauvau G,Geissmann F
25-0453 was used in in vitro experiments to show that macrophage/DC precursors (MDP) give rise to conventional DCs (cDCs),.
Mon Mar 16 00:00:00 EDT 2009
Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
Astrakhan A,Ochs HD,Rawlings DJ
25-0453 was used in Flow cytometry/Cell sorting to investigate the role for WASp within the iNKT lineage.
Mon Jun 15 00:00:00 EDT 2009
IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response.
Blood
Rubinstein MP,Lind NA,Purton JF,Filippou P,Best JA,McGhee PA,Surh CD,Goldrath AW
25-0453 was used in Flow cytometry/Cell sorting to study IL-7 and IL-15 regulation of CD8+ T-cell subsets during contraction of the immune response.
Sat Nov 01 00:00:00 EDT 2008
Donor deficiency of decay-accelerating factor accelerates murine T cell-mediated cardiac allograft rejection.
Journal of immunology (Baltimore, Md. : 1950)
Pavlov V,Raedler H,Yuan S,Leisman S,Kwan WH,Lalli PN,Medof ME,Heeger PS
25-0453 was used in Flow cytometry/Cell sorting to reveal that donor DAF expression regulates the strength of the direct alloreactive CD8(+) T cell response.
Wed Oct 01 00:00:00 EDT 2008
Trafficking of antigen-specific CD8+ T lymphocytes to mucosal surfaces following intramuscular vaccination.
Journal of immunology (Baltimore, Md. : 1950)
Kaufman DR,Liu J,Carville A,Mansfield KG,Havenga MJ,Goudsmit J,Barouch DH
25-0453 was used in Flow cytometry/Cell sorting to evaluate mucosal cellular immune responses in mice and rhesus monkeys after systemic immunisation with various replication-incompetent recombinant adenovirus vectors.
Mon Sep 15 00:00:00 EDT 2008
The surprising kinetics of the T cell response to live antigenic cells.
Journal of immunology (Baltimore, Md. : 1950)
Tyznik AJ,Bevan MJ
25-0453 was used in Flow cytometry/Cell sorting to demonstrate dramatic differences in host T cell responses to noninflammatory Ags compared with responses to pathogens.
Mon Oct 15 00:00:00 EDT 2007
Developmental switch of mouse hematopoietic stem cells from fetal to adult type occurs in bone marrow after birth.
Proceedings of the National Academy of Sciences of the United States of America
Kikuchi K,Kondo M
25-0453 was used in Flow cytometry/Cell sorting to demonstrate how foetal haematopoietic stem cells may acquire adult characteristics between 1 and 2 weeks after birth in mouse bone marrow.
Tue Nov 21 00:00:00 EST 2006
Characterization of marginal zone B cell precursors.
The Journal of experimental medicine
Srivastava B,Quinn WJ,Hazard K,Erikson J,Allman D
25-0453 was used in Flow cytometry/Cell sorting to suggest that marginal zone B cells develop by way of CD21/35(high) CD23(+) intermediates.
Mon Nov 07 00:00:00 EST 2005
Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo.
The American journal of pathology
Grimbaldeston MA,Chen CC,Piliponsky AM,Tsai M,Tam SY,Galli SJ
25-0453 was used in Flow cytometry/Cell sorting to investigate the applications of the Kit(W-sh/W-sh) mouse model for analysing mast cell function in vivo.
Thu Sep 01 00:00:00 EDT 2005
