Product References
High-Dose Acetaminophen with N-acetylcysteine Rescue Inhibits M2 Polarization of Tumor-Associated Macrophages.
Cancers
Bryan A,Pingali P,Joslyn M,Li H,Bernas T,Koblinski J,Landry J,Lee WS,Patel B,Neuwelt A
Published figure using MHC Class I (H-2Kb) monoclonal antibody (Product # 17-5958-82) in Flow Cytometry
Thu Sep 28 00:00:00 EDT 2023
CD8α+ dendritic cells potentiate antitumor and immune activities against murine ovarian cancers.
Scientific reports
Lee SW,Lee H,Lee KW,Kim MJ,Kang SW,Lee YJ,Kim H,Kim YM
Published figure using MHC Class I (H-2Kb) monoclonal antibody (Product # 17-5958-82) in Flow Cytometry
Tue Jan 03 00:00:00 EST 2023
Tumor-intrinsic YTHDF1 drives immune evasion and resistance to immune checkpoint inhibitors via promoting MHC-I degradation.
Nature communications
Lin W,Chen L,Zhang H,Qiu X,Huang Q,Wan F,Le Z,Geng S,Zhang A,Qiu S,Chen L,Kong L,Lu JJ
17-5958-82 was used in Flow cytometry/Cell sorting to reveal that tumor-intrinsic YTHDF1 drives immune evasion and immune checkpoint inhibitor (ICI) resistance.
Tue Jan 17 00:00:00 EST 2023
Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity.
Cancer discovery
Chen HA,Ho YJ,Mezzadra R,Adrover JM,Smolkin R,Zhu C,Woess K,Bernstein N,Schmitt G,Fong L,Luan W,Wuest A,Tian S,Li X,Broderick C,Hendrickson RC,Egeblad M,Chen Z,Alonso-Curbelo D,Lowe SW
Published figure using MHC Class I (H-2Kb) monoclonal antibody (Product # 17-5958-82) in Flow Cytometry
Mon Feb 06 00:00:00 EST 2023
Specific cannabinoids revive adaptive immunity by reversing immune evasion mechanisms in metastatic tumours.
Frontiers in immunology
Dada S,Ellis SLS,Wood C,Nohara LL,Dreier C,Garcia NH,Saranchova I,Munro L,Pfeifer CG,Eyford BA,Kari S,Garrovillas E,Caspani G,Al Haddad E,Gray PW,Morova T,Lack NA,Andersen RJ,Tjoelker L,Jefferies WA
Published figure using MHC Class I (H-2Kb) monoclonal antibody (Product # 17-5958-82) in Flow Cytometry
Mon Mar 20 00:00:00 EDT 2023
Mesenchymal stem cell exosome-derived miR-223 alleviates acute graft-versus-host disease via reducing the migration of donor T cells.
Stem cell research & therapy
Liu W,Zhou N,Liu Y,Zhang W,Li X,Wang Y,Zheng R,Zhang Y
17-5958-82 was used in Flow cytometry/Cell sorting to unveil a new role of MSCs-Exo containing miR-223 in the treatment of acute graft-versus-host disease (aGvHD).
Fri Feb 26 00:00:00 EST 2021
Mesenchymal stem cell exosome-derived miR-223 alleviates acute graft-versus-host disease via reducing the migration of donor T cells.
Stem cell research & therapy
Liu W,Zhou N,Liu Y,Zhang W,Li X,Wang Y,Zheng R,Zhang Y
17-5958-82 was used in Flow cytometry/Cell sorting to unveil a new role of MSCs-Exo containing miR-223 in the treatment of acute graft-versus-host disease (aGvHD).
Fri Feb 26 00:00:00 EST 2021
Frequent amplification of HDAC genes and efficacy of HDAC inhibitor chidamide and PD-1 blockade combination in soft tissue sarcoma.
Journal for immunotherapy of cancer
Que Y,Zhang XL,Liu ZX,Zhao JJ,Pan QZ,Wen XZ,Xiao W,Xu BS,Hong DC,Guo TH,Shen LJ,Fan WJ,Chen HY,Weng DS,Xu HR,Zhou PH,Zhang YZ,Niu XH,Zhang X
17-5958-82 was used in Flow Cytometry to conclude that the combination of chidamide and anti-programmed cell death 1 therapy represents a potentially important strategy for soft tissue sarcoma.
Mon Feb 01 00:00:00 EST 2021
Antigen dominance hierarchies shape TCF1+ progenitor CD8 T cell phenotypes in tumors.
Cell
Burger ML,Cruz AM,Crossland GE,Gaglia G,Ritch CC,Blatt SE,Bhutkar A,Canner D,Kienka T,Tavana SZ,Barandiaran AL,Garmilla A,Schenkel JM,Hillman M,de Los Rios Kobara I,Li A,Jaeger AM,Hwang WL,Westcott PMK,Manos MP,Holovatska MM,Hodi FS,Regev A,Santagata S,Jacks T
17-5958-82 was used in Flow cytometry/Cell sorting to conclude that vaccination eliminated CCR6+ TCF1+ cells and dramatically improved the subdominant response, highlighting a strategy to optimally engage concurrent neoantigen responses against tumors.
Thu Sep 16 00:00:00 EDT 2021
A mouse model for the study of anti-tumor T cell responses in Kras-driven lung adenocarcinoma.
Cell reports methods
Fitzgerald B,Connolly KA,Cui C,Fagerberg E,Mariuzza DL,Hornick NI,Foster GG,William I,Cheung JF,Joshi NS
17-5958-82 was used in Flow Cytometry to report the development of the immunogenic KP × NINJA (inversion inducible joined neoantigen) (KP-NINJA) LUAD model.
Mon Sep 27 00:00:00 EDT 2021
An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development.
Immunity
Chopp LB,Gopalan V,Ciucci T,Ruchinskas A,Rae Z,Lagarde M,Gao Y,Li C,Bosticardo M,Pala F,Livak F,Kelly MC,Hannenhalli S,Bosselut R
17-5958-82 was used in Flow Cytometry to identify mouse and human αβ thymocyte developmental trajectories.
Tue Dec 15 00:00:00 EST 2020
An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development.
Immunity
Chopp LB,Gopalan V,Ciucci T,Ruchinskas A,Rae Z,Lagarde M,Gao Y,Li C,Bosticardo M,Pala F,Livak F,Kelly MC,Hannenhalli S,Bosselut R
17-5958-82 was used in Flow Cytometry to identify mouse and human αβ thymocyte developmental trajectories.
Tue Dec 15 00:00:00 EST 2020
IFN-λ Enhances Constitutive Expression of MHC Class I Molecules on Thymic Epithelial Cells.
Journal of immunology (Baltimore, Md. : 1950)
Benhammadi M,Mathé J,Dumont-Lagacé M,Kobayashi KS,Gaboury L,Brochu S,Perreault C
17-5958-82 was used in Flow Cytometry to show unanticipated variation in MHC I expression by ECs from various sites and provides compelling evidence that superior expression of MHC I in TECs is crucial for proper thymocyte education.
Tue Sep 01 00:00:00 EDT 2020
Intravenous injection of the oncolytic virus M1 awakens antitumor T cells and overcomes resistance to checkpoint blockade.
Cell death & disease
Liu Y,Cai J,Liu W,Lin Y,Guo L,Liu X,Qin Z,Xu C,Zhang Y,Su X,Deng K,Yan G,Liang J
Published figure using MHC Class I (H-2Kb) monoclonal antibody (Product # 17-5958-82) in Flow Cytometry
Sat Dec 12 00:00:00 EST 2020
Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancer.
Scientific reports
Moufarrij S,Srivastava A,Gomez S,Hadley M,Palmer E,Austin PT,Chisholm S,Diab N,Roche K,Yu A,Li J,Zhu W,Lopez-Acevedo M,Villagra A,Chiappinelli KB
Published figure using MHC Class I (H-2Kb) monoclonal antibody (Product # 17-5958-82) in Flow Cytometry
Wed Feb 26 00:00:00 EST 2020
Bendamustine with total body irradiation conditioning yields tolerant T-cells while preserving T-cell-dependent graft-versus-leukemia.
Oncoimmunology
Stokes J,Hoffman EA,Molina MS,Kummet N,Simpson RJ,Zeng Y,Katsanis E
Published figure using MHC Class I (H-2Kb) monoclonal antibody (Product # 17-5958-82) in Flow Cytometry
Wed Jul 14 00:00:00 EDT 2021
Localized Treatment with Oncolytic Adenovirus Delta-24-RGDOX Induces Systemic Immunity against Disseminated Subcutaneous and Intracranial Melanomas.
Clinical cancer research : an official journal of the American Association for Cancer Research
Jiang H,Shin DH,Nguyen TT,Fueyo J,Fan X,Henry V,Carrillo CC,Yi Y,Alonso MM,Collier TL,Yuan Y,Lang FF,Gomez-Manzano C
17-5958 was used in Flow cytometry/Cell sorting to show that localized intratumoral injection of Delta-24-RGDOX induces an in situ antovaccination of the treated melanoma, the effect of which changes the immune landscape of the treated mice, resulting in systemic immunity against disseminated s.c. and i.c. tumors.
Fri Nov 15 00:00:00 EST 2019
CXCL14 suppresses human papillomavirus-associated head and neck cancer through antigen-specific CD8+ T-cell responses by upregulating MHC-I expression.
Oncogene
Westrich JA,Vermeer DW,Silva A,Bonney S,Berger JN,Cicchini L,Greer RO,Song JI,Raben D,Slansky JE,Lee JH,Spanos WC,Pyeon D
Published figure using MHC Class I (H-2Kb) monoclonal antibody (Product # 17-5958-82) in Flow Cytometry
Fri Nov 01 00:00:00 EDT 2019
Downregulation of Blimp1 inhibits the maturation of bone marrow-derived dendritic cells.
International journal of molecular medicine
Xiao J,Zhang J,Li X,Dai X,Wang J,He Y,Wei L,Shi J,Gong N
17-5958 was used in Flow cytometry/Cell sorting to demonstrate that transduction with lenti-shRNA-Blimp1 (lentiviral-mediated B-lymphocyte-induced maturation protein-1 shRNA) modulated the maturation of DCs via MHC-II molecule suppression and inhibited alloreactive T cell activation.
Fri Feb 01 00:00:00 EST 2019
Platelet-derived β2m regulates age related monocyte/macrophage functions.
Aging
Hilt ZT,Ture SK,Mohan A,Arne A,Morrell CN
Published figure using MHC Class I (H-2Kb) monoclonal antibody (Product # 17-5958-82) in Flow Cytometry
Wed Dec 18 00:00:00 EST 2019
Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells.
Cell reports
Ohigashi I,Tanaka Y,Kondo K,Fujimori S,Kondo H,Palin AC,Hoffmann V,Kozai M,Matsushita Y,Uda S,Motosugi R,Hamazaki J,Kubota H,Murata S,Tanaka K,Katagiri T,Kosako H,Takahama Y
Published figure using MHC Class I (H-2Kb) monoclonal antibody (Product # 17-5958-82) in Flow Cytometry
Tue Nov 26 00:00:00 EST 2019
Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti-PD-1 response in NSCLC.
Life science alliance
Bullock BL,Kimball AK,Poczobutt JM,Neuwelt AJ,Li HY,Johnson AM,Kwak JW,Kleczko EK,Kaspar RE,Wagner EK,Hopp K,Schenk EL,Weiser-Evans MC,Clambey ET,Nemenoff RA
17-5958-82 was used in Flow Cytometry to demonstrate that targeted enhancement of tumor-intrinsic IFNγ signaling can induce a cascade of changes associated with increased therapeutic vulnerability.
Sat Jun 01 00:00:00 EDT 2019
Quiescent Tissue Stem Cells Evade Immune Surveillance.
Immunity
Agudo J,Park ES,Rose SA,Alibo E,Sweeney R,Dhainaut M,Kobayashi KS,Sachidanandam R,Baccarini A,Merad M,Brown BD
17-5958 was used in Flow cytometry/Cell sorting to identify a link between stem cell quiescence, antigen presentation, and immune evasion.
Tue Feb 20 00:00:00 EST 2018
Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export.
Proceedings of the National Academy of Sciences of the United States of America
Grotzke JE,Kozik P,Morel JD,Impens F,Pietrosemoli N,Cresswell P,Amigorena S,Demangel C
Published figure using MHC Class I (H-2Kb) monoclonal antibody (Product # 17-5958-82) in Flow Cytometry
Tue Jul 18 00:00:00 EDT 2017
Cross-Presentation of Soluble and Cell-Associated Antigen by Murine Hepatocytes Is Enhanced by Collectrin Expression.
Journal of immunology (Baltimore, Md. : 1950)
Dolina JS,Cechova S,Rudy CK,Sung SJ,Tang WW,Lee J,Hahn YS,Le TH
17-5958 was used in Flow cytometry/Cell sorting to identify the functional role of collectrin in the liver.
Wed Mar 15 00:00:00 EDT 2017
Contractile actomyosin arcs promote the activation of primary mouse T cells in a ligand-dependent manner.
PloS one
Hong J,Murugesan S,Betzig E,Hammer JA
17-5958 was used in Flow cytometry/Cell sorting to investigate the ligand-dependent contribution made by contractile actomyosin arcs populating the peripheral supramolecular activation cluster region of the immunological synapse to T cell receptor microcluster transport and proximal signaling in primary mouse T cells.
Mon Oct 16 00:00:00 EDT 2017
Metabolic reprogramming of alloantigen-activated T cells after hematopoietic cell transplantation.
The Journal of clinical investigation
Nguyen HD,Chatterjee S,Haarberg KM,Wu Y,Bastian D,Heinrichs J,Fu J,Daenthanasanmak A,Schutt S,Shrestha S,Liu C,Wang H,Chi H,Mehrotra S,Yu XZ
17-5958 was used in Flow cytometry/Cell sorting to study the metabolic reprogramming of donor T cells following allogeneic haematopoietic cell transplantation.
Fri Apr 01 00:00:00 EDT 2016
HDAC Inhibitors Enhance T-Cell Chemokine Expression and Augment Response to PD-1 Immunotherapy in Lung Adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Zheng H,Zhao W,Yan C,Watson CC,Massengill M,Xie M,Massengill C,Noyes DR,Martinez GV,Afzal R,Chen Z,Ren X,Antonia SJ,Haura EB,Ruffell B,Beg AA
17-5958 was used in Flow cytometry/Cell sorting to test whether strategies that increase T-cell infiltration to tumours can be efficacious in enhancing immunotherapy response.
Mon Aug 15 00:00:00 EDT 2016
G-CSF-Induced Suppressor IL-10+ Neutrophils Promote Regulatory T Cells That Inhibit Graft-Versus-Host Disease in a Long-Lasting and Specific Way.
Journal of immunology (Baltimore, Md. : 1950)
Perobelli SM,Mercadante AC,Galvani RG,Gonçalves-Silva T,Alves AP,Pereira-Neves A,Benchimol M,Nóbrega A,Bonomo A
17-5958 was used in Flow cytometry/Cell sorting to study the role of incoming IL-10+ neutrophils from G-CSF-treated donor spleen in inhibiting acute graft-versus-host disease.
Tue Nov 01 00:00:00 EDT 2016
Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells.
Nature communications
Baptista MA,Keszei M,Oliveira M,Sunahara KK,Andersson J,Dahlberg CI,Worth AJ,Liedén A,Kuo IC,Wallin RP,Snapper SB,Eidsmo L,Scheynius A,Karlsson MC,Bouma G,Burns SO,Forsell MN,Thrasher AJ,Nylén S,Westerberg LS
Published figure using MHC Class I (H-2Kb) monoclonal antibody (Product # 17-5958-82) in Flow Cytometry
Mon Jul 18 00:00:00 EDT 2016
Anti-angiogenic efficacy of 5'-triphosphate siRNA combining VEGF silencing and RIG-I activation in NSCLCs.
Oncotarget
Yuan D,Xia M,Meng G,Xu C,Song Y,Wei J
Published figure using MHC Class I (H-2Kb) monoclonal antibody (Product # 17-5958-82) in Flow Cytometry
Tue Oct 06 00:00:00 EDT 2015
Epitope Prediction Assays Combined with Validation Assays Strongly Narrows down Putative Cytotoxic T Lymphocyte Epitopes.
Vaccines
Ip PP,Nijman HW,Daemen T
17-5958 was used in Flow cytometry/Cell sorting to investigate the most promising C57BL/6 mouse-restricted Hepatitis C virus (HCV) MHC class I epitopes and validate these epitopes in vitro and in vivo.
Tue Mar 24 00:00:00 EDT 2015
Identities of P2 and P3 Residues of H-2Kb-Bound Peptides Determine Mouse Ly49C Recognition.
PloS one
Marquez EA,Kane KP
17-5958 was used in Flow cytometry/Cell sorting to identify two adjacent amino acid residues, P2 and P3, in the peptide binding groove of H-2kb, which determine mouse Ly49C specificity.
Wed Mar 30 00:00:00 EDT 2016
Alphavirus-based vaccines encoding nonstructural proteins of hepatitis C virus induce robust and protective T-cell responses.
Molecular therapy : the journal of the American Society of Gene Therapy
Ip PP,Boerma A,Regts J,Meijerhof T,Wilschut J,Nijman HW,Daemen T
17-5958 was used in Flow cytometry/Cell sorting to study an rSFV-based vector which induces robust T-cell activity and has a potential for the treatment of HCV infections.
Tue Apr 01 00:00:00 EDT 2014
The N-terminal domain of NLRC5 confers transcriptional activity for MHC class I and II gene expression.
Journal of immunology (Baltimore, Md. : 1950)
Neerincx A,Jakobshagen K,Utermöhlen O,Büning H,Steimle V,Kufer TA
17-5958 was used in Flow cytometry/Cell sorting to demonstrate the function of NLRC5 and CIITA in MHC gene regulation.
Mon Sep 15 00:00:00 EDT 2014
IL-3 and CSF-1 interact to promote generation of CD11c+ IL-10-producing macrophages.
PloS one
Sheng KC,Herrero LJ,Taylor A,Hapel AJ,Mahalingam S
17-5958 was used in Flow cytometry/Cell sorting to investigate the mechanisms of regulation of hematopoiesis.
Tue Dec 30 00:00:00 EST 2014
Multifaceted therapeutic targeting of ovarian peritoneal carcinomatosis through virus-induced immunomodulation.
Molecular therapy : the journal of the American Society of Gene Therapy
Gujar S,Dielschneider R,Clements D,Helson E,Shmulevitz M,Marcato P,Pan D,Pan LZ,Ahn DG,Alawadhi A,Lee PW
17-5958 was used in Flow cytometry/Cell sorting to develop a virus-based therapy that suppresses immunomodulation and targets ovarian peritoneal carcinomatosis.
Fri Feb 01 00:00:00 EST 2013
Protection of islet grafts through transforming growth factor-β-induced tolerogenic dendritic cells.
Diabetes
Thomas DC,Wong FS,Zaccone P,Green EA,Wållberg M
17-5958 was used in Flow cytometry/Cell sorting to investigate methods to achieve long-term β-islet graft tolerance for diabetes type 1, showing that islets can be protected through expression of TGF-β.
Sun Sep 01 00:00:00 EDT 2013
Dynamic in situ cytometry uncovers T cell receptor signaling during immunological synapses and kinapses in vivo.
Immunity
Moreau HD,Lemaître F,Terriac E,Azar G,Piel M,Lennon-Dumenil AM,Bousso P
17-5958 was used in Flow cytometry/Cell sorting to examine how T cells sense TCR ligands of varying affinities in vivo.
Fri Aug 24 00:00:00 EDT 2012
Novel murine dendritic cell lines: a powerful auxiliary tool for dendritic cell research.
Frontiers in immunology
Fuertes Marraco SA,Grosjean F,Duval A,Rosa M,Lavanchy C,Ashok D,Haller S,Otten LA,Steiner QG,Descombes P,Luber CA,Meissner F,Mann M,Szeles L,Reith W,Acha-Orbea H
17-5958 was used in Flow cytometry/Cell sorting to report the generation of new murine DC lines, named MutuDC, originating from cultures of splenic CD8α conventional DC (cDC) tumours.
Tue Nov 20 00:00:00 EST 2012
