Product References
T cell responses at diagnosis of amyotrophic lateral sclerosis predict disease progression.
Nature communications
Yazdani S,Seitz C,Cui C,Lovik A,Pan L,Piehl F,Pawitan Y,Kläppe U,Press R,Samuelsson K,Yin L,Vu TN,Joly AL,Westerberg LS,Evertsson B,Ingre C,Andersson J,Fang F
25-1278-42 was used in Flow cytometry/Cell sorting to show, by flow cytometric analysis of blood and cerebrospinal fluid (CSF) samples of a cohort of 89 newly diagnosed ALS patients in Stockholm, Sweden, that T cell phenotypes at the time of diagnosis are good predictors of disease outcome.
Tue Nov 08 00:00:00 EST 2022
Organoids capture tissue-specific innate lymphoid cell development in mice and humans.
Cell reports
Jowett GM,Read E,Roberts LB,Coman D,Vilà González M,Zabinski T,Niazi U,Reis R,Trieu TJ,Danovi D,Gentleman E,Vallier L,Curtis MA,Lord GM,Neves JF
25-1278-42 was used in Flow Cytometry to demonstrate that human epithelial cells recapitulate maturation of ILC from a stringent systemic human ILCP population, but only when the organoid-associated stromal cells are depleted.
Tue Aug 30 00:00:00 EDT 2022
Immunometabolic analysis shows a distinct cyto-metabotype in Covid-19 compared to sepsis from other causes.
Heliyon
Trovato FM,Mujib S,Jerome E,Cavazza A,Morgan P,Smith J,Depante MT,O'Reilly K,Luxton J,Mare T,Napoli S,McPhail MJ
25-1278-42 was used in Flow cytometry/Cell sorting to support the hypothesis that IFN-γ -PD-L1 axis might be involved in the cytokine release syndrome typical of severe Covid-19 and the phenomenon persisted through multiple pandemic waves despite use of immunomodulation.
Wed Jun 01 00:00:00 EDT 2022
The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19.
Cell
Consiglio CR,Cotugno N,Sardh F,Pou C,Amodio D,Rodriguez L,Tan Z,Zicari S,Ruggiero A,Pascucci GR,Santilli V,Campbell T,Bryceson Y,Eriksson D,Wang J,Marchesi A,Lakshmikanth T,Campana A,Villani A,Rossi P,Landegren N,Palma P,Brodin P
25-1278 was used in Flow cytometry/Cell sorting to show that inflammatory response in MIS-C differs from the cytokine storm of severe acute COVID-19 and shares several features with Kawasaki disease, but also significant differences.
Thu Nov 12 00:00:00 EST 2020
Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques.
JCI insight
Petitdemange C,Kasturi SP,Kozlowski PA,Nabi R,Quarnstrom CF,Reddy PBJ,Derdeyn CA,Spicer LM,Patel P,Legere T,Kovalenkov YO,Labranche CC,Villinger F,Tomai M,Vasilakos J,Haynes B,Kang CY,Gibbs JS,Yewdell JW,Barouch D,Wrammert J,Montefiori D,Hunter E,Amara RR,Masopust D,Pulendran B
25-1278-42 was used in Flow Cytometry to demonstrate that vaccination strategies that induce both CD8+ T cell and antibody responses can confer enhanced protection against infection.
Thu Feb 21 00:00:00 EST 2019
JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias.
Genes & development
Kim SK,Knight DA,Jones LR,Vervoort S,Ng AP,Seymour JF,Bradner JE,Waibel M,Kats L,Johnstone RW
Fri Jun 01 00:00:00 EDT 2018
Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation.
Cell
Lim AI,Li Y,Lopez-Lastra S,Stadhouders R,Paul F,Casrouge A,Serafini N,Puel A,Bustamante J,Surace L,Masse-Ranson G,David E,Strick-Marchand H,Le Bourhis L,Cocchi R,Topazio D,Graziano P,Muscarella LA,Rogge L,Norel X,Sallenave JM,Allez M,Graf T,Hendriks RW,Casanova JL,Amit I,Yssel H,Di Santo JP
25-1278 was used in Flow cytometry/Cell sorting to identify circulating and tissue ILC precursors in humans that fail to express the transcription factors and cytokine outputs of mature ILCs but have these signature loci in an epigenetically poised configuration.
Thu Mar 09 00:00:00 EST 2017
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.
Cell
Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z
Thu Sep 21 00:00:00 EDT 2017
Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling.
PLoS pathogens
Seshadri S,Allan DSJ,Carlyle JR,Zenewicz LA
25-1278 was used in Flow cytometry/Cell sorting to study the effects of MAPK signalling pathways in group 3 innate immune lymphocytes using Bacillus anthracis.
Sun Oct 01 00:00:00 EDT 2017
Guidelines for the use of flow cytometry and cell sorting in immunological studies.
European journal of immunology
Cossarizza A,Chang HD,Radbruch A,Akdis M,Andrä I,Annunziato F,Bacher P,Barnaba V,Battistini L,Bauer WM,Baumgart S,Becher B,Beisker W,Berek C,Blanco A,Borsellino G,Boulais PE,Brinkman RR,Büscher M,Busch DH,Bushnell TP,Cao X,Cavani A,Chattopadhyay PK,Cheng Q,Chow S,Clerici M,Cooke A,Cosma A,Cosmi L,Cumano A,Dang VD,Davies D,De Biasi S,Del Zotto G,Della Bella S,Dellabona P,Deniz G,Dessing M,Diefenbach A,Di Santo J,Dieli F,Dolf A,Donnenberg VS,Dörner T,Ehrhardt GRA,Endl E,Engel P,Engelhardt B,Esser C,Everts B,Dreher A,Falk CS,Fehniger TA,Filby A,Fillatreau S,Follo M,Förster I,Foster J,Foulds GA,Frenette PS,Galbraith D,Garbi N,García-Godoy MD,Geginat J,Ghoreschi K,Gibellini L,Goettlinger C,Goodyear CS,Gori A,Grogan J,Gross M,Grützkau A,Grummitt D,Hahn J,Hammer Q,Hauser AE,Haviland DL,Hedley D,Herrera G,Herrmann M,Hiepe F,Holland T,Hombrink P,Houston JP,Hoyer BF,Huang B,Hunter CA,Iannone A,Jäck HM,Jávega B,Jonjic S,Juelke K,Jung S,Kaiser T,Kalina T,Keller B,Khan S,Kienhöfer D,Kroneis T,Kunkel D,Kurts C,Kvistborg P,Lannigan J,Lantz O,Larbi A,LeibundGut-Landmann S,Leipold MD,Levings MK,Litwin V,Liu Y,Lohoff M,Lombardi G,Lopez L,Lovett-Racke A,Lubberts E,Ludewig B,Lugli E,Maecker HT,Martrus G,Matarese G,Maueröder C,McGrath M,McInnes I,Mei HE,Melchers F,Melzer S,Mielenz D,Mills K,Mirrer D,Mjösberg J,Moore J,Moran B,Moretta A,Moretta L,Mosmann TR,Müller S,Müller W,Münz C,Multhoff G,Munoz LE,Murphy KM,Nakayama T,Nasi M,Neudörfl C,Nolan J,Nourshargh S,O'Connor JE,Ouyang W,Oxenius A,Palankar R,Panse I,Peterson P,Peth C,Petriz J,Philips D,Pickl W,Piconese S,Pinti M,Pockley AG,Podolska MJ,Pucillo C,Quataert SA,Radstake TRDJ,Rajwa B,Rebhahn JA,Recktenwald D,Remmerswaal EBM,Rezvani K,Rico LG,Robinson JP,Romagnani C,Rubartelli A,Ruckert B,Ruland J,Sakaguchi S,Sala-de-Oyanguren F,Samstag Y,Sanderson S,Sawitzki B,Scheffold A,Schiemann M,Schildberg F,Schimisky E,Schmid SA,Schmitt S,Schober K,Schüler T,Schulz AR,Schumacher T,Scotta C,Shankey TV,Shemer A,Simon AK,Spidlen J,Stall AM,Stark R,Stehle C,Stein M,Steinmetz T,Stockinger H,Takahama Y,Tarnok A,Tian Z,Toldi G,Tornack J,Traggiai E,Trotter J,Ulrich H,van der Braber M,van Lier RAW,Veldhoen M,Vento-Asturias S,Vieira P,Voehringer D,Volk HD,von Volkmann K,Waisman A,Walker R,Ward MD,Warnatz K,Warth S,Watson JV,Watzl C,Wegener L,Wiedemann A,Wienands J,Willimsky G,Wing J,Wurst P,Yu L,Yue A,Zhang Q,Zhao Y,Ziegler S,Zimmermann J
25-1278 was used in Flow cytometry/Cell sorting to collect the currently accepted best methods for monitoring most of the variation of the major players of immune system.
Sun Oct 01 00:00:00 EDT 2017
Interleukin-10-producing LAG3+ regulatory T cells are associated with disease activity and abatacept treatment in rheumatoid arthritis.
Arthritis research & therapy
Nakachi S,Sumitomo S,Tsuchida Y,Tsuchiya H,Kono M,Kato R,Sakurai K,Hanata N,Nagafuchi Y,Tateishi S,Kanda H,Okamura T,Yamamoto K,Fujio K
25-1278 was used in Flow cytometry/Cell sorting to conclude that IL-10-producing LAG3(+) Tregs are associated with the immunopathology and therapeutic response in RA. LAG3(+) Tregs may participate in a mechanism for the anti-inflammatory and immune-modulating effects of targeted therapy for costimulation.
Tue May 16 00:00:00 EDT 2017
Cytomegalovirus infection in HIV-infected and uninfected individuals is characterized by circulating regulatory T cells of unconstrained antigenic specificity.
PloS one
Tovar-Salazar A,Weinberg A
25-1278 was used in Flow cytometry/Cell sorting to indicate that CMV-seropositive individuals have circulating Tregs that inhibit cell-mediated immune responses to CMV and other antigens and may be contribute to an immune-suppressive effect of CMV infection.
Fri Oct 06 00:00:00 EDT 2017
Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.
Science translational medicine
Dendrou CA,Cortes A,Shipman L,Evans HG,Attfield KE,Jostins L,Barber T,Kaur G,Kuttikkatte SB,Leach OA,Desel C,Faergeman SL,Cheeseman J,Neville MJ,Sawcer S,Compston A,Johnson AR,Everett C,Bell JI,Karpe F,Ultsch M,Eigenbrot C,McVean G,Fugger L
25-1278 was used in Flow cytometry/Cell sorting to reveal a protective homozygous effect that defined a signalling optimum between autoimmunity and immunodeficiency and identified TYK2 as a potential drug target for autoimmune disorders.
Wed Nov 02 00:00:00 EDT 2016
Impact of immunosuppressive drugs on the therapeutic efficacy of ex vivo expanded human regulatory T cells.
Haematologica
Scottà C,Fanelli G,Hoong SJ,Romano M,Lamperti EN,Sukthankar M,Guggino G,Fazekasova H,Ratnasothy K,Becker PD,Afzali B,Lechler RI,Lombardi G
25-1278 was used in Flow cytometry/Cell sorting to study the effect of immunosuppressive drugs on Treg cells.
Fri Jan 01 00:00:00 EST 2016
Increased expression of inducible co-stimulator on CD4+ T-cells in the peripheral blood and synovial fluid of patients with failed hip arthroplasties.
Bone & joint research
Revell PA,Matharu GS,Mittal S,Pynsent PB,Buckley CD,Revell MP
25-1278 was used in Flow cytometry/Cell sorting to investigate CD4+ T-cell phenotypes in the peripheral blood (PB) and synovial fluid (SF) of patients undergoing revision surgery for failed hip arthroplasties, and in patients awaiting total hip arthroplasty.
Mon Feb 01 00:00:00 EST 2016
Dexamethasone co-medication in cancer patients undergoing chemotherapy causes substantial immunomodulatory effects with implications for chemo-immunotherapy strategies.
Oncoimmunology
Cook AM,McDonnell AM,Lake RA,Nowak AK
25-1278 was used in Flow cytometry/Cell sorting to investigate the immunological changes induced by co-medications, ushc as dexamethasone, commonly used in the clinic.
Tue Mar 01 00:00:00 EST 2016
Immunophenotyping of rheumatoid arthritis reveals a linkage between HLA-DRB1 genotype, CXCR4 expression on memory CD4(+) T cells, and disease activity.
Scientific reports
Nagafuchi Y,Shoda H,Sumitomo S,Nakachi S,Kato R,Tsuchida Y,Tsuchiya H,Sakurai K,Hanata N,Tateishi S,Kanda H,Ishigaki K,Okada Y,Suzuki A,Kochi Y,Fujio K,Yamamoto K
25-1278 was used in Flow cytometry/Cell sorting to perform 24-subset immunophenotyping of peripheral blood mononuclear cells in HLA-DRB1-genotyped rheumatoid arthritis patients and healthy donors.
Thu Jul 07 00:00:00 EDT 2016
Sequential intranodal immunotherapy induces antitumor immunity and correlated regression of disseminated follicular lymphoma.
Blood
Kolstad A,Kumari S,Walczak M,Madsbu U,Hagtvedt T,Bogsrud TV,Kvalheim G,Holte H,Aurlien E,Delabie J,Tierens A,Olweus J
25-1278 was used in Flow cytometry/Cell sorting to explore the efficacy and immunogenicity of sequential intranodal immunotherapy, a novel in situ immunotherapeutic strategy.
Thu Jan 01 00:00:00 EST 2015
IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients.
Diabetologia
Ferreira RC,Simons HZ,Thompson WS,Cutler AJ,Dopico XC,Smyth DJ,Mashar M,Schuilenburg H,Walker NM,Dunger DB,Wallace C,Todd JA,Wicker LS,Pekalski ML
25-1278 was used in Flow cytometry/Cell sorting to indicate that increased IL-21 production is likely to be an aetiological factor in the pathogenesis of type 1 diabetes.
Wed Apr 01 00:00:00 EDT 2015
The immunosuppressive enzyme IL4I1 promotes FoxP3(+) regulatory T lymphocyte differentiation.
European journal of immunology
Cousin C,Aubatin A,Le Gouvello S,Apetoh L,Castellano F,Molinier-Frenkel V
Mon Jun 01 00:00:00 EDT 2015
Vitamins A and D have antagonistic effects on expression of effector cytokines and gut-homing integrin in human innate lymphoid cells.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Ruiter B,Patil SU,Shreffler WG
25-1278 was used in Flow cytometry/Cell sorting to investigate the effects of retinoic acid and the active form of vitamin D, 1,25-dihydroxyvitamin D3, on human innate lymphoid cells.
Wed Jul 01 00:00:00 EDT 2015
TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses.
Nature communications
Okamura T,Sumitomo S,Morita K,Iwasaki Y,Inoue M,Nakachi S,Komai T,Shoda H,Miyazaki J,Fujio K,Yamamoto K
25-1278 was used in Flow cytometry/Cell sorting to investigate the role of GF-β3-expressing CD4+CD25(-)LAG3+ Tregs in humoral immune responses.
Thu Feb 19 00:00:00 EST 2015
Poly(ADP-ribosyl)ation of FOXP3 Protein Mediated by PARP-1 Protein Regulates the Function of Regulatory T Cells.
The Journal of biological chemistry
Luo X,Nie J,Wang S,Chen Z,Chen W,Li D,Hu H,Li B
25-1278 was used in Flow cytometry/Cell sorting to investigate the roles of PARP-1 in the immune system.
Fri Nov 27 00:00:00 EST 2015
Skewed distribution of IL-7 receptor-α-expressing effector memory CD8+ T cells with distinct functional characteristics in oral squamous cell carcinoma.
PloS one
Lee JJ,Yeh CY,Jung CJ,Chen CW,Du MK,Yu HM,Yang CJ,Lin HY,Sun A,Ko JY,Cheng SJ,Chang YL,Chia JS
25-1278 was used in Flow cytometry/Cell sorting to demonstrate that IL-7 receptor expression on CD8+ T cells may differentiate the CD45RA+/2 CCR72 effector memory CD8+ T-cell subsets that exhibit distinct functional characteristics and association with tumour progression in OSCC patients.
Tue Nov 11 00:00:00 EST 2014
PIM1 kinase phosphorylates the human transcription factor FOXP3 at serine 422 to negatively regulate its activity under inflammation.
The Journal of biological chemistry
Li Z,Lin F,Zhuo C,Deng G,Chen Z,Yin S,Gao Z,Piccioni M,Tsun A,Cai S,Zheng SG,Zhang Y,Li B
25-1278 was used in Flow cytometry/Cell sorting to investigate PIM1 as a negative regulator of FOXP3-mediated transcriptional control and therefore the immunosuppressive activity of regulatory T cells.
Fri Sep 26 00:00:00 EDT 2014
The number of CCR5 expressing CD4+ T lymphocytes is lower in HIV-infected long-term non-progressors with viral control compared to normal progressors: a cross-sectional study.
BMC infectious diseases
Meijerink H,Indrati AR,van Crevel R,Joosten I,Koenen H,van der Ven AJ
25-1278 was used in Flow cytometry/Cell sorting to determine levels of CCR5 and CXCR4 expression among CD4(+) and CD8(+) lymphocyte subsets in HIV-infected long-term non-progressors.
Sat Dec 13 00:00:00 EST 2014
Human secondary lymphoid organs typically contain polyclonally-activated proliferating regulatory T cells.
Blood
Peters JH,Koenen HJ,Fasse E,Tijssen HJ,Ijzermans JN,Groenen PJ,Schaap NP,Kwekkeboom J,Joosten I
25-1278 was used in Flow cytometry/Cell sorting to suggest that human secondary lymphoid organs aid in the maintenance and regulation of regulatory T-cell function and homeostasis.
Thu Sep 26 00:00:00 EDT 2013
Peripheral Th17/Treg imbalance in patients with atherosclerotic cerebral infarction.
International journal of clinical and experimental pathology
Li Q,Wang Y,Yu F,Wang YM,Zhang C,Hu C,Wu Z,Xu X,Hu S
25-1278 was used in Flow cytometry/Cell sorting to study how Th17/Treg cells were imbalanced in ACI patients, and ox-LDL may contribute to this imbalance and lead to the occurrence of ACI.
Mon Dec 23 00:00:00 EST 2013
Increased numbers of circulating CD8 effector memory T cells before transplantation enhance the risk of acute rejection in lung transplant recipients.
PloS one
San Segundo D,Ballesteros MÁ,Naranjo S,Zurbano F,Miñambres E,López-Hoyos M
25-1278 was used in Flow cytometry/Cell sorting to suggest a correlation between acute rejection and effector memory T-cells in lung transplant recipients.
Fri Jul 25 00:00:00 EDT 2014
Distinct different sensitivity of Treg and Th17 cells to Fas-mediated apoptosis signaling in patients with acute coronary syndrome.
International journal of clinical and experimental pathology
Li Q,Wang Y,Wang Y,Zhou Q,Chen K,Wang YM,Wei W,Wang Y
25-1278 was used in Flow cytometry/Cell sorting to elucidate the mechanisms causing Th17/Treg imbalance in acute coronary syndrome patients.
Tue Jul 09 00:00:00 EDT 2013
Synergy between IL-6 and TGF-β signaling promotes FOXP3 degradation.
International journal of clinical and experimental pathology
Gao Z,Gao Y,Li Z,Chen Z,Lu D,Tsun A,Li B
25-1278 was used in Flow cytometry/Cell sorting to found that IL-6/TGF-β treatment upregulated IL-6R expression but did not affect the stability of FOXP3 mRNA.
Thu Feb 07 00:00:00 EST 2013
Regulatory and activated T cells in human Schistosoma haematobium infections.
PloS one
Nausch N,Midzi N,Mduluza T,Maizels RM,Mutapi F
25-1278 was used in Flow cytometry/Cell sorting to investigate the relationship between schistosome infection intensity and Tregs and activated T cells.
Thu Feb 10 00:00:00 EST 2011
IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection.
Blood
Sereti I,Dunham RM,Spritzler J,Aga E,Proschan MA,Medvik K,Battaglia CA,Landay AL,Pahwa S,Fischl MA,Asmuth DM,Tenorio AR,Altman JD,Fox L,Moir S,Malaspina A,Morre M,Buffet R,Silvestri G,Lederman MM
25-1278 was used in Flow cytometry/Cell sorting to study how rhIL-7 has a biologic and toxicity profile suggesting a potential for therapeutic trials in HIV infection and other settings of lymphopenia.
Thu Jun 18 00:00:00 EDT 2009
Loss of IL-7 receptor alpha on CD4+ T cells defines terminally differentiated B cell-helping effector T cells in a B cell-rich lymphoid tissue.
Journal of immunology (Baltimore, Md. : 1950)
Lim HW,Kim CH
Sat Dec 01 00:00:00 EST 2007
Loss of IL-7 receptor alpha on CD4+ T cells defines terminally differentiated B cell-helping effector T cells in a B cell-rich lymphoid tissue.
Journal of immunology (Baltimore, Md. : 1950)
Lim HW,Kim CH
Sat Dec 01 00:00:00 EST 2007
