Product References
Ex vivo assays show human gamma-delta T cells specific for common allergens are Th1-polarized in allergic donors.
Cell reports methods
Yu ED,Wang E,Garrigan E,Sutherland A,Khalil N,Kearns K,Pham J,Schulten V,Peters B,Frazier A,Sette A,da Silva Antunes R
45-0088-42 was used in flow cytometry to support the existence of allergen-reactive γδ T cells and their potential use in rebalancing dysregulated Th2 responses in allergic diseases.
Mon Dec 19 00:00:00 EST 2022
c-Met specific CAR-T cells as a targeted therapy for non-small cell lung cancer cell A549.
Bioengineered
Min J,Long C,Zhang L,Duan J,Fan H,Chu F,Li Z
45-0088-42 was used in Flow cytometry/Cell sorting to generate c-Met CAR- T cells, which exhibit enhanced cytotoxicity against NSCLC cells in vitro and in vivo.
Fri Apr 01 00:00:00 EDT 2022
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes.
Nature communications
Renner K,Schwittay T,Chaabane S,Gottschling J,Müller C,Tiefenböck C,Salewski JN,Winter F,Buchtler S,Balam S,Malfertheiner MV,Lubnow M,Lunz D,Graf B,Hitzenbichler F,Hanses F,Poeck H,Kreutz M,Orsó E,Burkhardt R,Niedermair T,Brochhausen C,Gessner A,Salzberger B,Mack M
Published figure using CD8a monoclonal antibody (Product # 45-0088-42) in Flow Cytometry
Fri May 21 00:00:00 EDT 2021
Multipeptide stimulated PBMCs generate TEM/TCM for adoptive cell therapy in multiple myeloma.
Oncotarget
Vardam-Kaur T,Pathangey LB,McCormick DJ,Bergsagel PL,Cohen PA,Gendler SJ
Published figure using CD8a monoclonal antibody (Product # 45-0088-42) in Flow Cytometry
Tue Sep 28 00:00:00 EDT 2021
Human endoglin-CD3 bispecific T cell engager antibody induces anti-tumor effect in vivo.
Theranostics
Zhong L,Shi W,Gan L,Liu X,Huo Y,Wu P,Zhang Z,Wu T,Peng H,Huang Y,Zhao Y,Yuan Y,Deng Z,Tang H
Published figure using CD8a monoclonal antibody (Product # 45-0088-42) in Flow Cytometry
Wed Jul 28 00:00:00 EDT 2021
Bispecific T-Cell Engaging Antibodies Against MUC16 Demonstrate Efficacy Against Ovarian Cancer in Monotherapy and in Combination With PD-1 and VEGF Inhibition.
Frontiers in immunology
Yeku OO,Rao TD,Laster I,Kononenko A,Purdon TJ,Wang P,Cui Z,Liu H,Brentjens RJ,Spriggs D
Published figure using CD8a monoclonal antibody (Product # 45-0088-42) in Flow Cytometry
Thu Oct 21 00:00:00 EDT 2021
Complement C1s and C4d as Prognostic Biomarkers in Renal Cancer: Emergence of Noncanonical Functions of C1s.
Cancer immunology research
Daugan MV,Revel M,Russick J,Dragon-Durey MA,Gaboriaud C,Robe-Rybkine T,Poillerat V,Grunenwald A,Lacroix G,Bougouin A,Meylan M,Verkarre V,Oudard SM,Mejean A,Vano YA,Perkins G,Validire P,Cathelineau X,Sanchez-Salas R,Damotte D,Fremeaux-Bacchi V,Cremer I,Sautès-Fridman C,Fridman WH,Roumenina LT
45-0088-42 was used in Flow cytometry/Cell sorting to find that complement activation, as reflected by high plasma C4d or as C4d deposits at the tumor site, was associated with poor prognosis in two cohorts of patients with ccRCC.
Sun Aug 01 00:00:00 EDT 2021
Preventing ATP Degradation by ASO-Mediated Knockdown of CD39 and CD73 Results in A2aR-Independent Rescue of T Cell Proliferation.
Molecular therapy. Nucleic acids
Festag J,Thelemann T,Schell M,Raith S,Michel S,Jaschinski F,Klar R
Published figure using CD8a monoclonal antibody (Product # 45-0088-42) in Flow Cytometry
Fri Sep 04 00:00:00 EDT 2020
Identification and Characterization of CD4+ T Cell Epitopes after Shingrix Vaccination.
Journal of virology
Voic H,de Vries RD,Sidney J,Rubiro P,Moore E,Phillips E,Mallal S,Schwan B,Weiskopf D,Sette A,Grifoni A
45-0088-42 was used in Flow Cytometry to elucidate the role of T cell immunity in differential clinical outcomes to varicella zoster vaccines.
Mon Nov 23 00:00:00 EST 2020
A Cross-Reactive Small Protein Binding Domain Provides a Model to Study Off-Tumor CAR-T Cell Toxicity.
Molecular therapy oncolytics
Hammill JA,Kwiecien JM,Dvorkin-Gheva A,Lau VWC,Baker C,Wu Y,Bezverbnaya K,Aarts C,Heslen CW,Denisova GF,Derocher H,Milne K,Nelson BH,Bramson JL
45-0088 was used in Flow cytometry/Cell sorting to study the pathogenesis of CAR-T cell off-tumour toxicities in a xenograft model.
Fri Jun 26 00:00:00 EDT 2020
A Cross-Reactive Small Protein Binding Domain Provides a Model to Study Off-Tumor CAR-T Cell Toxicity.
Molecular therapy oncolytics
Hammill JA,Kwiecien JM,Dvorkin-Gheva A,Lau VWC,Baker C,Wu Y,Bezverbnaya K,Aarts C,Heslen CW,Denisova GF,Derocher H,Milne K,Nelson BH,Bramson JL
45-0088 was used in Flow cytometry/Cell sorting to study the pathogenesis of CAR-T cell off-tumour toxicities in a xenograft model.
Fri Jun 26 00:00:00 EDT 2020
Phase I Study of Ficlatuzumab and Cetuximab in Cetuximab-Resistant, Recurrent/Metastatic Head and Neck Cancer.
Cancers
Bauman JE,Ohr J,Gooding WE,Ferris RL,Duvvuri U,Kim S,Johnson JT,Soloff AC,Wallweber G,Winslow J,Gaither-Davis A,Grandis JR,Stabile LP
45-0088-42 was used in Flow Cytometry to establish the recommended Phase II dose (RP2D). Secondary objectives included overall response rate (ORR), progression-free survival (PFS), and overall survival (OS).
Thu Jun 11 00:00:00 EDT 2020
Immunological Properties of Neural Crest Cells Derived from Human Induced Pluripotent Stem Cells.
Stem cells and development
Fujii S,Yoshida S,Inagaki E,Hatou S,Tsubota K,Takahashi M,Shimmura S,Sugita S
Published figure using CD8a monoclonal antibody (Product # 45-0088-42) in Flow Cytometry
Tue Jan 01 00:00:00 EST 2019
Simian Immunodeficiency Virus Infection of Rhesus Macaques Results in Delayed Zika Virus Clearance.
mBio
Vinton CL,Magaziner SJ,Dowd KA,Robertson SJ,Amaro-Carambot E,Karmele EP,Ortiz AM,Starke CE,Mudd JC,Whitehead SS,Best SM,Pierson TC,Hickman HD,Brenchley JM
45-0088-42 was used in Flow Cytometry to highlight how individual components of the innate and adaptive immune responses which become perturbed in HIV-infected individuals influence ZIKV infection.
Tue Dec 03 00:00:00 EST 2019
The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity.
Nature communications
Helsen CW,Hammill JA,Lau VWC,Mwawasi KA,Afsahi A,Bezverbnaya K,Newhook L,Hayes DL,Aarts C,Bojovic B,Denisova GF,Kwiecien JM,Brain I,Derocher H,Milne K,Nelson BH,Bramson JL
45-0088 was used in Flow cytometry/Cell sorting to show that T cell antigen coupler-engineered T cells may have a superior therapeutic index relative to chimeric antigen receptor-T cells.
Fri Aug 03 00:00:00 EDT 2018
Fingolimod reduces circulating tight-junction protein levels and in vitro peripheral blood mononuclear cells migration in multiple sclerosis patients.
Scientific reports
Annunziata P,Cioni C,Masi G,Tassi M,Marotta G,Severi S
45-0088 was used in Flow cytometry/Cell sorting to study the effects of fingolimod on circulating tight-junction protein levels as well as on peripheral blood mononuclear cells migration.
Thu Oct 18 00:00:00 EDT 2018
Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer.
Cell research
Su S,Liao J,Liu J,Huang D,He C,Chen F,Yang L,Wu W,Chen J,Lin L,Zeng Y,Ouyang N,Cui X,Yao H,Su F,Huang JD,Lieberman J,Liu Q,Song E
Published figure using CD8a monoclonal antibody (Product # 45-0088-42) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2017
Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans.
The Journal of clinical investigation
Rathod KS,Kapil V,Velmurugan S,Khambata RS,Siddique U,Khan S,Van Eijl S,Gee LC,Bansal J,Pitrola K,Shaw C,D'Acquisto F,Colas RA,Marelli-Berg F,Dalli J,Ahluwalia A
45008842 was used in flow cytometry to propose that female sex protects against systemic inflammation-induced endothelial dysfunction
Tue Jan 03 00:00:00 EST 2017
Enhancement of cytokine-driven NK cell IFN-γ production after vaccination of HCMV infected Africans.
European journal of immunology
Darboe A,Danso E,Clarke E,Umesi A,Touray E,Wegmuller R,Moore SE,Riley EM,Goodier MR
45-0088 was used in Flow cytometry/Cell sorting to investigate the impact of advanced NK cell differentiation on vaccine-induced responses.
Thu Jun 01 00:00:00 EDT 2017
Decidual T Cells Exhibit a Highly Differentiated Phenotype and Demonstrate Potential Fetal Specificity and a Strong Transcriptional Response to IFN.
Journal of immunology (Baltimore, Md. : 1950)
Powell RM,Lissauer D,Tamblyn J,Beggs A,Cox P,Moss P,Kilby MD
45-0088 was used in Flow cytometry/Cell sorting to investigate the specificity and regulation of CD4+ and CD8+ T cells obtained from human third trimester decidua and demonstrated that decidual CD4+ and CD8+ T cells exhibit a highly differentiated effector memory phenotype in comparison with peripheral blood.
Wed Nov 15 00:00:00 EST 2017
siRNA‑mediated knockdown of T‑bet and RORγt contributes to decreased inflammation in pre‑eclampsia.
Molecular medicine reports
Wang J,Wen ZQ,Cheng XY,Mei TY,Chen ZF,Su LX
45-0088-42 was used in Flow Cytometry to determine whether a decrease in the expression of T‚bet can restore immune balance and alleviate the systemic inflammatory response present in preeclampsia.
Wed Nov 01 00:00:00 EDT 2017
Detection of Retinal Pigment Epithelium-Specific Antibody in iPSC-Derived Retinal Pigment Epithelium Transplantation Models.
Stem cell reports
Sugita S,Makabe K,Fujii S,Iwasaki Y,Kamao H,Shiina T,Ogasawara K,Takahashi M
Published figure using CD8a monoclonal antibody (Product # 45-0088-42) in Flow Cytometry
Tue Nov 14 00:00:00 EST 2017
Dominant immunosuppression of dendritic cell function by prostate-cancer-derived exosomes.
Journal of extracellular vesicles
Salimu J,Webber J,Gurney M,Al-Taei S,Clayton A,Tabi Z
45-0088 was used in Flow cytometry/Cell sorting to identify exosomal prostaglandin E2 as a driver of CD73 induction, as prostaglandin E2 receptor inhibition significantly reduced exosome-dependent CD73 induction.
Wed Sep 30 00:00:00 EDT 2020
Evidence for Resident Memory T Cells in Rasmussen Encephalitis.
Frontiers in immunology
Owens GC,Chang JW,Huynh MN,Chirwa T,Vinters HV,Mathern GW
45-0088 was used in Flow cytometry/Cell sorting to demonstrate that a cellular immune response to an as yet unidentified antigen(s) occurs at an early stage of Rasmussen encephalitis.
Fri Mar 04 00:00:00 EST 2016
Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection.
PLoS pathogens
Miles B,Miller SM,Folkvord JM,Levy DN,Rakasz EG,Skinner PJ,Connick E
Published figure using CD8a monoclonal antibody (Product # 45-0088-42) in Flow Cytometry
Sat Oct 01 00:00:00 EDT 2016
Human Head and Neck Squamous Cell Carcinoma-Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells.
Journal of immunology (Baltimore, Md. : 1950)
Younis RH,Han KL,Webb TJ
Published figure using CD8a monoclonal antibody (Product # 45-0088-42) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2016
Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria.
Stem cells international
Chen J,Wang Q,Feng X,Zhang Z,Geng L,Xu T,Wang D,Sun L
45-0088 was used in Flow cytometry/Cell sorting to show that T cells from SLE patients had higher autophagic activity than that from healthy controls.
Thu Oct 01 00:00:00 EDT 2020
CD28 family of receptors on T cells in chronic HBV infection: Expression characteristics, clinical significance and correlations with PD-1 blockade.
Molecular medicine reports
Tang ZS,Hao YH,Zhang EJ,Xu CL,Zhou Y,Zheng X,Yang DL
Published figure using CD8a monoclonal antibody (Product # 45-0088-42) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2016
Lack of T Cell Response to iPSC-Derived Retinal Pigment Epithelial Cells from HLA Homozygous Donors.
Stem cell reports
Sugita S,Iwasaki Y,Makabe K,Kimura T,Futagami T,Suegami S,Takahashi M
Published figure using CD8a monoclonal antibody (Product # 45-0088-42) in Flow Cytometry
Tue Oct 11 00:00:00 EDT 2016
Liposomal Glutathione Supplementation Restores TH1 Cytokine Response to Mycobacterium tuberculosis Infection in HIV-Infected Individuals.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
Ly J,Lagman M,Saing T,Singh MK,Tudela EV,Morris D,Anderson J,Daliva J,Ochoa C,Patel N,Pearce D,Venketaraman V
Published figure using CD8a monoclonal antibody (Product # 45-0088-42) in Flow Cytometry
Sun Nov 01 00:00:00 EDT 2015
Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection.
Nature communications
Miles B,Miller SM,Folkvord JM,Kimball A,Chamanian M,Meditz AL,Arends T,McCarter MD,Levy DN,Rakasz EG,Skinner PJ,Connick E
Published figure using CD8a monoclonal antibody (Product # 45-0088-42) in Flow Cytometry
Tue Oct 20 00:00:00 EDT 2015
RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection.
Nature communications
Jozwik A,Habibi MS,Paras A,Zhu J,Guvenel A,Dhariwal J,Almond M,Wong EHC,Sykes A,Maybeno M,Del Rosario J,Trujillo-Torralbo MB,Mallia P,Sidney J,Peters B,Kon OM,Sette A,Johnston SL,Openshaw PJ,Chiu C
Published figure using CD8a monoclonal antibody (Product # 45-0088-42) in Flow Cytometry
Mon Dec 21 00:00:00 EST 2015
Investigating the causes for decreased levels of glutathione in individuals with type II diabetes.
PloS one
Lagman M,Ly J,Saing T,Kaur Singh M,Vera Tudela E,Morris D,Chi PT,Ochoa C,Sathananthan A,Venketaraman V
Published figure using CD8a monoclonal antibody (Product # 45-0088-42) in Flow Cytometry
Wed Dec 30 00:00:00 EST 2015
Immune response to JC virus T antigen in patients with and without colorectal neoplasia.
Gut microbes
Butcher LD,Garcia M,Arnold M,Ueno H,Goel A,Boland CR
Published figure using CD8a monoclonal antibody (Product # 45-0088-42) in Flow Cytometry
Tue Jul 01 00:00:00 EDT 2014
T cell-derived IL-22 amplifies IL-1β-driven inflammation in human adipose tissue: relevance to obesity and type 2 diabetes.
Diabetes
Dalmas E,Venteclef N,Caer C,Poitou C,Cremer I,Aron-Wisnewsky J,Lacroix-Desmazes S,Bayry J,Kaveri SV,Clément K,André S,Guerre-Millo M
45-0088 was used in Flow cytometry/Cell sorting to investigate the contribution of different cytokines to the proinflammatory signature of adipose tissue macrophages in type 2 diabetic obese patients.
Sun Jun 01 00:00:00 EDT 2014
CD4+CD25(high), CD8+CD28- cells and thyroid autoantibodies in breast cancer patients.
Central-European journal of immunology
Biylgi O,Karagöz B,Türken O,Gültepe M,Özgün A,Tunçel T,Emirzeoğlu L,Çelik S,Müftüoğlu T,Gökhan Kandemir E
Published figure using CD8a monoclonal antibody (Product # 45-0088-42) in Flow Cytometry
Thu Jul 09 00:00:00 EDT 2015
Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8+ T cells.
Proceedings of the National Academy of Sciences of the United States of America
Weiskopf D,Angelo MA,de Azeredo EL,Sidney J,Greenbaum JA,Fernando AN,Broadwater A,Kolla RV,De Silva AD,de Silva AM,Mattia KA,Doranz BJ,Grey HM,Shresta S,Peters B,Sette A
45-0088 was used in Flow cytometry/Cell sorting to analyse dengue virus-specific responses, supporting an HLA-linked protective role for CD8+ T cells.
Tue May 28 00:00:00 EDT 2013
Long-term immune reconstitution of naive and memory t cell pools after haploidentical hematopoietic stem cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Azevedo RI,Soares MV,Albuquerque AS,Tendeiro R,Soares RS,Martins M,Ligeiro D,Victorino RM,Lacerda JF,Sousa AE
45-0088 was used in Flow cytometry/Cell sorting to show that long-term immune reconstitution was successfully achieved after haploidentical hematopoietic stem cell transplantation, a process that appears to have largely relied on de novo T cell production.
Wed May 01 00:00:00 EDT 2013
CD8+ T cell responses to lytic EBV infection: late antigen specificities as subdominant components of the total response.
Journal of immunology (Baltimore, Md. : 1950)
Abbott RJ,Quinn LL,Leese AM,Scholes HM,Pachnio A,Rickinson AB
45-0088 was used in Flow cytometry/Cell sorting to investigate late Ag-specific responses in polyclonal T cell cultures, showing late antigen specificities as subdominant components of the total response.
Sun Dec 01 00:00:00 EST 2013
Ex vivo analysis of resident hepatic pro-inflammatory CD1d-reactive T cells and hepatocyte surface CD1d expression in hepatitis C.
Journal of viral hepatitis
Yanagisawa K,Yue S,van der Vliet HJ,Wang R,Alatrakchi N,Golden-Mason L,Schuppan D,Koziel MJ,Rosen HR,Exley MA
Published figure using CD8a monoclonal antibody (Product # 45-0088-42) in Flow Cytometry
Thu Aug 01 00:00:00 EDT 2013
Increased frequency of CD4 and CD8 regulatory T cells in individuals under 15 years with multibacillary leprosy.
PloS one
Fernandes C,Gonçalves HS,Cabral PB,Pinto HC,Pinto MI,Câmara LM
45-0088 was used in Flow cytometry/Cell sorting to investigate the role of Tregs in leprosy in individuals under 15 years old.
Mon Aug 18 00:00:00 EDT 2014
Treatment of SIV-infected sooty mangabeys with a type-I IFN agonist results in decreased virus replication without inducing hyperimmune activation.
Blood
Vanderford TH,Slichter C,Rogers KA,Lawson BO,Obaede R,Else J,Villinger F,Bosinger SE,Silvestri G
45-0088 was used in Flow cytometry/Cell sorting to determine whether low levels of IFN-I signalling may help to prevent chronic immune activation and disease progression in SIV-infected sooty mangabeys.
Thu Jun 14 00:00:00 EDT 2012
Negative regulation of hepatitis C virus specific immunity is highly heterogeneous and modulated by pegylated interferon-alpha/ribavirin therapy.
PloS one
Claassen MA,de Knegt RJ,Turgut D,Groothuismink ZM,Janssen HL,Boonstra A
45-0088 was used in Flow cytometry/Cell sorting to investigate the impact of pegylated interferon-alpha and ribavirin on the inhibition of T-cell responses against hepatitis C.
Tue Jun 25 00:00:00 EDT 2013
Upregulation of programmed death-1 on T cells and programmed death ligand-1 on monocytes in septic shock patients.
Critical care (London, England)
Zhang Y,Li J,Lou J,Zhou Y,Bo L,Zhu J,Zhu K,Wan X,Cai Z,Deng X
Published figure using CD8a monoclonal antibody (Product # 45-0088-42) in Flow Cytometry
Wed Dec 07 00:00:00 EST 2011
Human CD8⁺ and CD4⁺ T cell memory to lymphocytic choriomeningitis virus infection.
Journal of virology
Kotturi MF,Swann JA,Peters B,Arlehamn CL,Sidney J,Kolla RV,James EA,Akondy RS,Ahmed R,Kwok WW,Buchmeier MJ,Sette A
45-0088 was used in Flow cytometry/Cell sorting to analyse the T cell response to acute lymphocytic choriomeningitis virus infection.
Tue Nov 01 00:00:00 EDT 2011
Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice.
Journal of leukocyte biology
Unsinger J,McDonough JS,Shultz LD,Ferguson TA,Hotchkiss RS
Published figure using CD8a monoclonal antibody (Product # 45-0088-42) in Flow Cytometry
Sat Aug 01 00:00:00 EDT 2009
B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity.
Retrovirology
Brudek T,Christensen T,Aagaard L,Petersen T,Hansen HJ,Møller-Larsen A
Published figure using CD8a monoclonal antibody (Product # 45-0088-42) in Flow Cytometry
Mon Nov 16 00:00:00 EST 2009
