Product References
Conserved stromal-immune cell circuits secure B cell homeostasis and function.
Nature immunology
Lütge M,De Martin A,Gil-Cruz C,Perez-Shibayama C,Stanossek Y,Onder L,Cheng HW,Kurz L,Cadosch N,Soneson C,Robinson MD,Stoeckli SJ,Ludewig B,Pikor NB
50-0443-82 was used in Flow cytometry/Cell sorting to reveal that a canonical set of immune cell-provided cues enforce bidirectional signaling programs that sustain functional BRC niches across lymphoid organs and species, thereby securing efficient humoral immunity.
Sat Jul 01 00:00:00 EDT 2023
Lactation-associated macrophages exist in murine mammary tissue and human milk.
Nature immunology
Cansever D,Petrova E,Krishnarajah S,Mussak C,Welsh CA,Mildenberger W,Mulder K,Kreiner V,Roussel E,Stifter SA,Andreadou M,Zwicky P,Jurado NP,Rehrauer H,Tan G,Liu Z,Blériot C,Ronchi F,Macpherson AJ,Ginhoux F,Natalucci G,Becher B,Greter M
50-0443-82 was used in Flow cytometry/Cell sorting to reveal the emergence of unique macrophages in the mammary gland and milk during lactation.
Sat Jul 01 00:00:00 EDT 2023
Immuno-localization of definitive hematopoietic stem cells in the vascular niche of mouse fetal liver.
STAR protocols
Biswas A,Singh SK,Kartha GM,Khurana S
Published figure using LYVE1 monoclonal antibody (Product # 50-0443-82) in Immunohistochemistry
Fri Dec 16 00:00:00 EST 2022
Deciphering the heterogeneity of the Lyve1+ perivascular macrophages in the mouse brain.
Nature communications
Siret C,van Lessen M,Bavais J,Jeong HW,Reddy Samawar SK,Kapupara K,Wang S,Simic M,de Fabritus L,Tchoghandjian A,Fallet M,Huang H,Sarrazin S,Sieweke MH,Stumm R,Sorokin L,Adams RH,Schulte-Merker S,Kiefer F,van de Pavert SA
50-0443-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen) to show that the parenchymal perivascular macrophage (pvM) population is more heterogenous than previously described, and includes a CD45low and CX3CR1- pvM population.
Wed Nov 30 00:00:00 EST 2022
Deciphering the heterogeneity of the Lyve1+ perivascular macrophages in the mouse brain.
Nature communications
Siret C,van Lessen M,Bavais J,Jeong HW,Reddy Samawar SK,Kapupara K,Wang S,Simic M,de Fabritus L,Tchoghandjian A,Fallet M,Huang H,Sarrazin S,Sieweke MH,Stumm R,Sorokin L,Adams RH,Schulte-Merker S,Kiefer F,van de Pavert SA
50-0443-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen) to show that the parenchymal perivascular macrophage (pvM) population is more heterogenous than previously described, and includes a CD45low and CX3CR1- pvM population.
Wed Nov 30 00:00:00 EST 2022
Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation.
Nature immunology
Mirchandani AS,Jenkins SJ,Bain CC,Sanchez-Garcia MA,Lawson H,Coelho P,Murphy F,Griffith DM,Zhang A,Morrison T,Ly T,Arienti S,Sadiku P,Watts ER,Dickinson RS,Reyes L,Cooper G,Clark S,Lewis D,Kelly V,Spanos C,Musgrave KM,Delaney L,Harper I,Scott J,Parkinson NJ,Rostron AJ,Baillie JK,Clohisey S,Pridans C,Campana L,Lewis PS,Simpson AJ,Dockrell DH,Schwarze J,Hirani N,Ratcliffe PJ,Pugh CW,Kranc K,Forbes SJ,Whyte MKB,Walmsley SR
50-0443-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen) to investigate how hypoxia affects immune landscape in ARDS patients.
Wed Jun 01 00:00:00 EDT 2022
Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain.
eLife
Kovacs MA,Cowan MN,Babcock IW,Sibley LA,Still K,Batista SJ,Labuzan SA,Sethi I,Harris TH
50-0443-82 was used in Immunohistochemistry to reveal that CNS lymphatic drainage supports the development of peripheral T cell responses against T. gondii but remains dispensable for immune protection of the brain.
Wed Dec 21 00:00:00 EST 2022
Single-cell analysis of skeletal muscle macrophages reveals age-associated functional subpopulations.
eLife
Krasniewski LK,Chakraborty P,Cui CY,Mazan-Mamczarz K,Dunn C,Piao Y,Fan J,Shi C,Wallace T,Nguyen C,Rathbun IA,Munk R,Tsitsipatis D,De S,Sen P,Ferrucci L,Gorospe M
50-0443-82 was used in Flow cytometry/Cell sorting to identify dynamically polarized skeletal muscle (SKM) macrophages and propose that specific macrophage subpopulations contribute to the proinflammatory and senescent traits of old SKM.
Wed Oct 19 00:00:00 EDT 2022
Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner.
eLife
Richards M,Nwadozi E,Pal S,Martinsson P,Kaakinen M,Gloger M,Sjöberg E,Koltowska K,Betsholtz C,Eklund L,Nordling S,Claesson-Welsh L
50-0443-82 was used in Flow cytometry/Cell sorting to identify structural and functional in vivo characteristics of the endothelial cell barrier.
Thu Jul 21 00:00:00 EDT 2022
Integrins mediate placental extracellular vesicle trafficking to lung and liver in vivo.
Scientific reports
Nguyen SL,Ahn SH,Greenberg JW,Collaer BW,Agnew DW,Arora R,Petroff MG
Published figure using LYVE1 monoclonal antibody (Product # 50-0443-82) in Immunohistochemistry
Thu Feb 18 00:00:00 EST 2021
Nasal administration of mitochondria reverses chemotherapy-induced cognitive deficits.
Theranostics
Alexander JF,Seua AV,Arroyo LD,Ray PR,Wangzhou A,Heiβ-Lückemann L,Schedlowski M,Price TJ,Kavelaars A,Heijnen CJ
Published figure using LYVE1 monoclonal antibody (Product # 50-0443-82) in Immunocytochemistry
Tue Jul 27 00:00:00 EDT 2021
Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer.
Nature communications
Nishina T,Deguchi Y,Ohshima D,Takeda W,Ohtsuka M,Shichino S,Ueha S,Yamazaki S,Kawauchi M,Nakamura E,Nishiyama C,Kojima Y,Adachi-Akahane S,Hasegawa M,Nakayama M,Oshima M,Yagita H,Shibuya K,Mikami T,Inohara N,Matsushima K,Tada N,Nakano H
Published figure using LYVE1 monoclonal antibody (Product # 50-0443-82) in Flow Cytometry
Fri Apr 16 00:00:00 EDT 2021
Extracellular ATP Limits Homeostatic T Cell Migration Within Lymph Nodes.
Frontiers in immunology
Kobayashi D,Sugiura Y,Umemoto E,Takeda A,Ueta H,Hayasaka H,Matsuzaki S,Katakai T,Suematsu M,Hamachi I,Yegutkin GG,Salmi M,Jalkanen S,Miyasaka M
Published figure using LYVE1 monoclonal antibody (Product # 50-0443-82) in Immunohistochemistry
Mon Feb 14 00:00:00 EST 2022
Extracellular ATP Limits Homeostatic T Cell Migration Within Lymph Nodes.
Frontiers in immunology
Kobayashi D,Sugiura Y,Umemoto E,Takeda A,Ueta H,Hayasaka H,Matsuzaki S,Katakai T,Suematsu M,Hamachi I,Yegutkin GG,Salmi M,Jalkanen S,Miyasaka M
Published figure using LYVE1 monoclonal antibody (Product # 50-0443-82) in Immunohistochemistry
Mon Feb 14 00:00:00 EST 2022
Targeting local lymphatics to ameliorate heterotopic ossification via FGFR3-BMPR1a pathway.
Nature communications
Zhang D,Huang J,Sun X,Chen H,Huang S,Yang J,Du X,Tan Q,Luo F,Zhang R,Zhou S,Jiang W,Ni Z,Wang Z,Jin M,Xu M,Li F,Chen L,Liu M,Su N,Luo X,Yin L,Zhu Y,Feng JQ,Chen D,Qi H,Chen L,Xie Y
Published figure using LYVE1 monoclonal antibody (Product # 50-0443-82) in Immunocytochemistry
Mon Jul 19 00:00:00 EDT 2021
Structural cells are key regulators of organ-specific immune responses.
Nature
Krausgruber T,Fortelny N,Fife-Gernedl V,Senekowitsch M,Schuster LC,Lercher A,Nemc A,Schmidl C,Rendeiro AF,Bergthaler A,Bock C
50-0443 was used in Flow cytometry/Cell sorting to investigate the regulation of and characterise the immune genes in epithelia and endothelia structural cells and fibroblasts using mouse specimens.
Wed Jul 01 00:00:00 EDT 2020
Meningeal lymphatic vessels regulate brain tumor drainage and immunity.
Cell research
Hu X,Deng Q,Ma L,Li Q,Chen Y,Liao Y,Zhou F,Zhang C,Shao L,Feng J,He T,Ning W,Kong Y,Huo Y,He A,Liu B,Zhang J,Adams R,He Y,Tang F,Bian X,Luo J
Published figure using LYVE1 monoclonal antibody (Product # 50-0443-82) in Flow Cytometry
Sun Mar 01 00:00:00 EST 2020
Meningeal lymphatic vessels regulate brain tumor drainage and immunity.
Cell research
Hu X,Deng Q,Ma L,Li Q,Chen Y,Liao Y,Zhou F,Zhang C,Shao L,Feng J,He T,Ning W,Kong Y,Huo Y,He A,Liu B,Zhang J,Adams R,He Y,Tang F,Bian X,Luo J
Published figure using LYVE1 monoclonal antibody (Product # 50-0443-82) in Flow Cytometry
Sun Mar 01 00:00:00 EST 2020
Tissue-resident macrophages in omentum promote metastatic spread of ovarian cancer.
The Journal of experimental medicine
Etzerodt A,Moulin M,Doktor TK,Delfini M,Mossadegh-Keller N,Bajenoff M,Sieweke MH,Moestrup SK,Auphan-Anezin N,Lawrence T
Published figure using LYVE1 monoclonal antibody (Product # 50-0443-82) in Flow Cytometry
Mon Apr 06 00:00:00 EDT 2020
FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake.
Molecular medicine (Cambridge, Mass.)
Shrestha S,Cho W,Stump B,Imani J,Lamattina AM,Louis PH,Pazzanese J,Rosas IO,Visner G,Perrella MA,El-Chemaly S
Published figure using LYVE1 monoclonal antibody (Product # 50-0443-82) in Flow Cytometry
Fri Jul 31 00:00:00 EDT 2020
Anatomic evidence shows that lymphatic drainage exists in the pituitary to loop the cerebral lymphatic circulation.
Medical hypotheses
Elham E,Wumaier R,Wang C,Luo X,Chen T,Zhong N
Published figure using LYVE1 monoclonal antibody (Product # 50-0443-82) in Immunohistochemistry
Thu Oct 01 00:00:00 EDT 2020
Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage.
Nature communications
Chen J,Wang L,Xu H,Xing L,Zhuang Z,Zheng Y,Li X,Wang C,Chen S,Guo Z,Liang Q,Wang Y
50-0443 was used in Immunohistochemistry-immunofluorescence to demonstrate that the meningeal lymphatics drain extravasated erythrocytes from CSF into CLNs after SAH, while suggesting that modulating this draining may offer therapeutic approaches to alleviate SAH severity.
Mon Jun 22 00:00:00 EDT 2020
Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage.
Nature communications
Chen J,Wang L,Xu H,Xing L,Zhuang Z,Zheng Y,Li X,Wang C,Chen S,Guo Z,Liang Q,Wang Y
50-0443 was used in Immunohistochemistry-immunofluorescence to demonstrate that the meningeal lymphatics drain extravasated erythrocytes from CSF into CLNs after SAH, while suggesting that modulating this draining may offer therapeutic approaches to alleviate SAH severity.
Mon Jun 22 00:00:00 EDT 2020
Efficient Tissue Clearing and Multi-Organ Volumetric Imaging Enable Quantitative Visualization of Sparse Immune Cell Populations During Inflammation.
Frontiers in immunology
Hofmann J,Gadjalova I,Mishra R,Ruland J,Keppler SJ
Published figure using LYVE1 monoclonal antibody (Product # 50-0443-82) in Immunocytochemistry
Wed Jun 16 00:00:00 EDT 2021
Efficient Tissue Clearing and Multi-Organ Volumetric Imaging Enable Quantitative Visualization of Sparse Immune Cell Populations During Inflammation.
Frontiers in immunology
Hofmann J,Gadjalova I,Mishra R,Ruland J,Keppler SJ
Published figure using LYVE1 monoclonal antibody (Product # 50-0443-82) in Immunocytochemistry
Wed Jun 16 00:00:00 EDT 2021
Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis.
Nature communications
Bolte AC,Dutta AB,Hurt ME,Smirnov I,Kovacs MA,McKee CA,Ennerfelt HE,Shapiro D,Nguyen BH,Frost EL,Lammert CR,Kipnis J,Lukens JR
Published figure using LYVE1 monoclonal antibody (Product # 50-0443-82) in Immunohistochemistry
Thu Sep 10 00:00:00 EDT 2020
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis.
Nature communications
Strunz M,Simon LM,Ansari M,Kathiriya JJ,Angelidis I,Mayr CH,Tsidiridis G,Lange M,Mattner LF,Yee M,Ogar P,Sengupta A,Kukhtevich I,Schneider R,Zhao Z,Voss C,Stoeger T,Neumann JHL,Hilgendorff A,Behr J,O'Reilly M,Lehmann M,Burgstaller G,Königshoff M,Chapman HA,Theis FJ,Schiller HB
50-0443 was used in Flow cytometry/Cell sorting to propose that in lung fibrosis, perturbed molecular checkpoints on the way to terminal differentiation can cause aberrant persistence of regenerative intermediate stem cell states.
Thu Jul 16 00:00:00 EDT 2020
Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche.
Immunity
Bonnardel J,T'Jonck W,Gaublomme D,Browaeys R,Scott CL,Martens L,Vanneste B,De Prijck S,Nedospasov SA,Kremer A,Van Hamme E,Borghgraef P,Toussaint W,De Bleser P,Mannaerts I,Beschin A,van Grunsven LA,Lambrecht BN,Taghon T,Lippens S,Elewaut D,Saeys Y,Guilliams M
50-0443-82 was used in Flow Cytometry to show that the Kupffer cell niche is composed of stellate cells, hepatocytes, and endothelial cells that together imprint the liver-specific macrophage identity.
Tue Oct 15 00:00:00 EDT 2019
Complex Non-sinus-associated Pachymeningeal Lymphatic Structures: Interrelationship With Blood Microvasculature.
Frontiers in physiology
Glinskii OV,Huxley VH,Xie L,Bunyak F,Palaniappan K,Glinsky VV
Published figure using LYVE1 monoclonal antibody (Product # 50-0443-82) in Immunofluorescence
Tue Sep 29 00:00:00 EDT 2020
Neuroinflammation-induced lymphangiogenesis near the cribriform plate contributes to drainage of CNS-derived antigens and immune cells.
Nature communications
Hsu M,Rayasam A,Kijak JA,Choi YH,Harding JS,Marcus SA,Karpus WJ,Sandor M,Fabry Z
50-0443 was used in Immunohistochemistry to show that increased lymphangiogenesis near the cribriform plate can contribute to the management of neuroinflammation-induced fluid accumulation and immune surveillance.
Wed Jan 16 00:00:00 EST 2019
CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature.
Nature neuroscience
Louveau A,Herz J,Alme MN,Salvador AF,Dong MQ,Viar KE,Herod SG,Knopp J,Setliff JC,Lupi AL,Da Mesquita S,Frost EL,Gaultier A,Harris TH,Cao R,Hu S,Lukens JR,Smirnov I,Overall CC,Oliver G,Kipnis J
50-0443 was used in Immunohistochemistry to demonstrate that meningeal lymphatics fulfill two critical criteria: they assist in the drainage of cerebrospinal fluid components and enable immune cells to enter draining lymph nodes in a CCR7-dependent manner.
Mon Oct 01 00:00:00 EDT 2018
Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen.
Immunity
Lim HY,Lim SY,Tan CK,Thiam CH,Goh CC,Carbajo D,Chew SHS,See P,Chakarov S,Wang XN,Lim LH,Johnson LA,Lum J,Fong CY,Bongso A,Biswas A,Goh C,Evrard M,Yeo KP,Basu R,Wang JK,Tan Y,Jain R,Tikoo S,Choong C,Weninger W,Poidinger M,Stanley RE,Collin M,Tan NS,Ng LG,Jackson DG,Ginhoux F,Angeli V
50-0443-82 was used in Quantitative reverse transcription PCR to unveil a hitherto unknown homeostatic contribution of arterial LYVE-1+ macrophages through the control of collagen production by SMCs and has identified a function of LYVE-1 in leukocytes.
Tue Aug 21 00:00:00 EDT 2018
Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen.
Immunity
Lim HY,Lim SY,Tan CK,Thiam CH,Goh CC,Carbajo D,Chew SHS,See P,Chakarov S,Wang XN,Lim LH,Johnson LA,Lum J,Fong CY,Bongso A,Biswas A,Goh C,Evrard M,Yeo KP,Basu R,Wang JK,Tan Y,Jain R,Tikoo S,Choong C,Weninger W,Poidinger M,Stanley RE,Collin M,Tan NS,Ng LG,Jackson DG,Ginhoux F,Angeli V
50-0443-82 was used in Quantitative reverse transcription PCR to unveil a hitherto unknown homeostatic contribution of arterial LYVE-1+ macrophages through the control of collagen production by SMCs and has identified a function of LYVE-1 in leukocytes.
Tue Aug 21 00:00:00 EDT 2018
FGF-dependent metabolic control of vascular development.
Nature
Yu P,Wilhelm K,Dubrac A,Tung JK,Alves TC,Fang JS,Xie Y,Zhu J,Chen Z,De Smet F,Zhang J,Jin SW,Sun L,Sun H,Kibbey RG,Hirschi KK,Hay N,Carmeliet P,Chittenden TW,Eichmann A,Potente M,Simons M
50-0443 was used in Flow cytometry/Cell sorting to identify FGF receptor signalling as a critical regulator of vascular development.
Thu May 11 00:00:00 EDT 2017
Lymphatic Endothelial Cells Produce M-CSF, Causing Massive Bone Loss in Mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Wang W,Wang H,Zhou X,Li X,Sun W,Dellinger M,Boyce BF,Xing L
Published figure using LYVE1 monoclonal antibody (Product # 50-0443-82) in Immunohistochemistry
Mon May 01 00:00:00 EDT 2017
Lymphatic Endothelial Cells Produce M-CSF, Causing Massive Bone Loss in Mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Wang W,Wang H,Zhou X,Li X,Sun W,Dellinger M,Boyce BF,Xing L
Published figure using LYVE1 monoclonal antibody (Product # 50-0443-82) in Immunohistochemistry
Mon May 01 00:00:00 EDT 2017
Long-term consequences of topical dexamethasone treatment during acute corneal HSV-1 infection on the immune system.
Journal of leukocyte biology
Chucair-Elliott AJ,Carr MM,Carr DJJ
Published figure using LYVE1 monoclonal antibody (Product # 50-0443-82) in Immunofluorescence
Mon May 01 00:00:00 EDT 2017
Long-term consequences of topical dexamethasone treatment during acute corneal HSV-1 infection on the immune system.
Journal of leukocyte biology
Chucair-Elliott AJ,Carr MM,Carr DJJ
Published figure using LYVE1 monoclonal antibody (Product # 50-0443-82) in Immunofluorescence
Mon May 01 00:00:00 EDT 2017
ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses.
Journal of immunology (Baltimore, Md. : 1950)
Lownik JC,Luker AJ,Damle SR,Cooley LF,El Sayed R,Hutloff A,Pitzalis C,Martin RK,El Shikh MEM,Conrad DH
50-0443 was used in Immunohistochemistry to demonstrate that a disintegrin and metalloproteinase (ADAM)10 is the primary physiological sheddase of ICOS ligand in mice and humans.
Sun Oct 01 00:00:00 EDT 2017
Defective lymphatic valve development and chylothorax in mice with a lymphatic-specific deletion of Connexin43.
Developmental biology
Munger SJ,Davis MJ,Simon AM
Published figure using LYVE1 monoclonal antibody (Product # 50-0443-82) in Immunohistochemistry
Sun Jan 15 00:00:00 EST 2017
Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice.
Arthritis research & therapy
Liang Q,Ju Y,Chen Y,Wang W,Li J,Zhang L,Xu H,Wood RW,Schwarz EM,Boyce BF,Wang Y,Xing L
Published figure using LYVE1 monoclonal antibody (Product # 50-0443-82) in Flow Cytometry
Sat Mar 12 00:00:00 EST 2016
Segregated Foxc2, NFATc1 and Connexin expression at normal developing venous valves, and Connexin-specific differences in the valve phenotypes of Cx37, Cx43, and Cx47 knockout mice.
Developmental biology
Munger SJ,Geng X,Srinivasan RS,Witte MH,Paul DL,Simon AM
Published figure using LYVE1 monoclonal antibody (Product # 50-0443-82) in Immunofluorescence
Fri Apr 15 00:00:00 EDT 2016
Diphtheria toxin-mediated ablation of lymphatic endothelial cells results in progressive lymphedema.
JCI insight
Gardenier JC,Hespe GE,Kataru RP,Savetsky IL,Torrisi JS,Nores GDG,Dayan JJ,Chang D,Zampell J,Martínez-Corral I,Ortega S,Mehrara BJ
50-0443 was used in Flow cytometry/Cell sorting to show that inflammatory changes after lymphatic injury play a key role in the pathophysiology of lymphedema.
Thu Sep 22 00:00:00 EDT 2016
Nonvenous origin of dermal lymphatic vasculature.
Circulation research
Martinez-Corral I,Ulvmar MH,Stanczuk L,Tatin F,Kizhatil K,John SW,Alitalo K,Ortega S,Makinen T
50-0443 was used in Flow cytometry/Cell sorting to investigate the origin of murine lymphatic vasculature, showing a significant contribution from nonvenous cells.
Fri May 08 00:00:00 EDT 2015
Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis.
Journal of cell science
Harada K,Yamazaki T,Iwata C,Yoshimatsu Y,Sase H,Mishima K,Morishita Y,Hirashima M,Oike Y,Suda T,Miura N,Watabe T,Miyazono K
Sun Nov 01 00:00:00 EDT 2009
