Product References
Embryonic keratin19+ progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla.
Nature communications
Lucas B,White AJ,Klein F,Veiga-Villauriz C,Handel A,Bacon A,Cosway EJ,James KD,Parnell SM,Ohigashi I,Takahama Y,Jenkinson WE,Hollander GA,Lu WY,Anderson G
53-5934-82 was used in Flow cytometry and Immunohistochemistry to identify and define a multipotent mTEC progenitor that emerges during embryogenesis to support mTEC diversity into adult life.
Wed Apr 12 00:00:00 EDT 2023
Embryonic keratin19+ progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla.
Nature communications
Lucas B,White AJ,Klein F,Veiga-Villauriz C,Handel A,Bacon A,Cosway EJ,James KD,Parnell SM,Ohigashi I,Takahama Y,Jenkinson WE,Hollander GA,Lu WY,Anderson G
53-5934-82 was used in Flow cytometry and Immunohistochemistry to identify and define a multipotent mTEC progenitor that emerges during embryogenesis to support mTEC diversity into adult life.
Wed Apr 12 00:00:00 EDT 2023
Embryonic keratin19+ progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla.
Nature communications
Lucas B,White AJ,Klein F,Veiga-Villauriz C,Handel A,Bacon A,Cosway EJ,James KD,Parnell SM,Ohigashi I,Takahama Y,Jenkinson WE,Hollander GA,Lu WY,Anderson G
53-5934-82 was used in Flow cytometry and Immunohistochemistry to identify and define a multipotent mTEC progenitor that emerges during embryogenesis to support mTEC diversity into adult life.
Wed Apr 12 00:00:00 EDT 2023
Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development.
eLife
Fujimori S,Ohigashi I,Abe H,Matsushita Y,Katagiri T,Taketo MM,Takahama Y,Takada S
Published figure using AIRE monoclonal antibody (Product # 53-5934-82) in Immunohistochemistry
Wed Jan 19 00:00:00 EST 2022
Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation.
The Journal of experimental medicine
Goldfarb Y,Givony T,Kadouri N,Dobeš J,Peligero-Cruz C,Zalayat I,Damari G,Dassa B,Ben-Dor S,Gruper Y,Oftedal BE,Bratland E,Erichsen MM,Berger A,Avin A,Nevo S,Haljasorg U,Kuperman Y,Ulman A,Haffner-Krausz R,Porat Z,Atasoy U,Leshkowitz D,Husebye ES,Abramson J
53-5934-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen) to elucidate why some autoimmune regulator (AIRE) mutations are recessive while others dominant and identify an autoregulatory mechanism by which AIRE negatively modulates its own expression.
Mon Nov 01 00:00:00 EDT 2021
Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation.
The Journal of experimental medicine
Goldfarb Y,Givony T,Kadouri N,Dobeš J,Peligero-Cruz C,Zalayat I,Damari G,Dassa B,Ben-Dor S,Gruper Y,Oftedal BE,Bratland E,Erichsen MM,Berger A,Avin A,Nevo S,Haljasorg U,Kuperman Y,Ulman A,Haffner-Krausz R,Porat Z,Atasoy U,Leshkowitz D,Husebye ES,Abramson J
53-5934-82 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen) to elucidate why some autoimmune regulator (AIRE) mutations are recessive while others dominant and identify an autoregulatory mechanism by which AIRE negatively modulates its own expression.
Mon Nov 01 00:00:00 EDT 2021
Sirt6 Regulates the Development of Medullary Thymic Epithelial Cells and Contributes to the Establishment of Central Immune Tolerance.
Frontiers in cell and developmental biology
Zhang Q,Liang Z,Zhang J,Lei T,Dong X,Su H,Chen Y,Zhang Z,Tan L,Zhao Y
Published figure using AIRE monoclonal antibody (Product # 53-5934-82) in Flow Cytometry
Wed Apr 21 00:00:00 EDT 2021
Defective dystrophic thymus determines degenerative changes in skeletal muscle.
Nature communications
Farini A,Sitzia C,Villa C,Cassani B,Tripodi L,Legato M,Belicchi M,Bella P,Lonati C,Gatti S,Cerletti M,Torrente Y
Published figure using AIRE monoclonal antibody (Product # 53-5934-82) in Immunocytochemistry
Thu Apr 08 00:00:00 EDT 2021
Defective dystrophic thymus determines degenerative changes in skeletal muscle.
Nature communications
Farini A,Sitzia C,Villa C,Cassani B,Tripodi L,Legato M,Belicchi M,Bella P,Lonati C,Gatti S,Cerletti M,Torrente Y
Published figure using AIRE monoclonal antibody (Product # 53-5934-82) in Immunocytochemistry
Thu Apr 08 00:00:00 EDT 2021
ILC3s control airway inflammation by limiting T cell responses to allergens and microbes.
Cell reports
Teng F,Tachó-Piñot R,Sung B,Farber DL,Worgall S,Hammad H,Lambrecht BN,Hepworth MR,Sonnenberg GF
Published figure using AIRE monoclonal antibody (Product # 53-5934-82) in Flow Cytometry
Tue Nov 23 00:00:00 EST 2021
OPG Production Matters Where It Happened.
Cell reports
Tsukasaki M,Asano T,Muro R,Huynh NC,Komatsu N,Okamoto K,Nakano K,Okamura T,Nitta T,Takayanagi H
53-5934-82 was used in Flow Cytometry to explore the cellular source of OPG by generating OPG-floxed mice and show that locally produced OPG, rather than circulating OPG, is crucial for bone and immune homeostasis.
Tue Sep 08 00:00:00 EDT 2020
Retracing the evolutionary emergence of thymopoiesis.
Science advances
Swann JB,Nusser A,Morimoto R,Nagakubo D,Boehm T
Published figure using AIRE monoclonal antibody (Product # 53-5934-82) in Immunohistochemistry
Sun Nov 01 00:00:00 EDT 2020
Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells.
Cell reports
Ohigashi I,Tanaka Y,Kondo K,Fujimori S,Kondo H,Palin AC,Hoffmann V,Kozai M,Matsushita Y,Uda S,Motosugi R,Hamazaki J,Kubota H,Murata S,Tanaka K,Katagiri T,Kosako H,Takahama Y
Published figure using AIRE monoclonal antibody (Product # 53-5934-82) in Immunohistochemistry
Tue Nov 26 00:00:00 EST 2019
MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance.
Autophagy
Liang Z,Zhang L,Su H,Luan R,Na N,Sun L,Zhao Y,Zhang X,Zhang Q,Li J,Zhang L,Zhao Y
Published figure using AIRE monoclonal antibody (Product # 53-5934-82) in Flow Cytometry
Fri Mar 22 00:00:00 EDT 2019
Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.
Cell host & microbe
Zhu F,Willette-Brown J,Song NY,Lomada D,Song Y,Xue L,Gray Z,Zhao Z,Davis SR,Sun Z,Zhang P,Wu X,Zhan Q,Richie ER,Hu Y
53-5934 was used in Immunohistochemistry to demonstrate that autoreactive T-cells and chronic fungal infection, fostered by inflammation and epithelial injury, promote esophageal squamous cell carcinoma development.
Wed Apr 12 00:00:00 EDT 2017
The transcriptional regulator Aire binds to and activates super-enhancers.
Nature immunology
Bansal K,Yoshida H,Benoist C,Mathis D
Published figure using AIRE monoclonal antibody (Product # 53-5934-82) in Western Blot
Wed Mar 01 00:00:00 EST 2017
The transcriptional regulator Aire binds to and activates super-enhancers.
Nature immunology
Bansal K,Yoshida H,Benoist C,Mathis D
Published figure using AIRE monoclonal antibody (Product # 53-5934-82) in Western Blot
Wed Mar 01 00:00:00 EST 2017
Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma.
The Journal of experimental medicine
Takahashi T,Asano Y,Sugawara K,Yamashita T,Nakamura K,Saigusa R,Ichimura Y,Toyama T,Taniguchi T,Akamata K,Noda S,Yoshizaki A,Tsuruta D,Trojanowska M,Sato S
Published figure using AIRE monoclonal antibody (Product # 53-5934-82) in Immunohistochemistry
Mon Apr 03 00:00:00 EDT 2017
Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma.
The Journal of experimental medicine
Takahashi T,Asano Y,Sugawara K,Yamashita T,Nakamura K,Saigusa R,Ichimura Y,Toyama T,Taniguchi T,Akamata K,Noda S,Yoshizaki A,Tsuruta D,Trojanowska M,Sato S
Published figure using AIRE monoclonal antibody (Product # 53-5934-82) in Immunohistochemistry
Mon Apr 03 00:00:00 EDT 2017
Thymic involution perturbs negative selection leading to autoreactive T cells that induce chronic inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Coder BD,Wang H,Ruan L,Su DM
Published figure using AIRE monoclonal antibody (Product # 53-5934-82) in Flow Cytometry
Mon Jun 15 00:00:00 EDT 2015
Osteoprotegerin-Mediated Homeostasis of Rank+ Thymic Epithelial Cells Does Not Limit Foxp3+ Regulatory T Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
McCarthy NI,Cowan JE,Nakamura K,Bacon A,Baik S,White AJ,Parnell SM,Jenkinson EJ,Jenkinson WE,Anderson G
53-5934 was used in Flow cytometry/Cell sorting to elucidate the conditions controlling medullary thymic epithelial cell (mTEC) homeostasis and the production of mTEC-dependent Foxp3(+) Tregs.
Tue Sep 15 00:00:00 EDT 2015
Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus.
Nature communications
Yanagihara T,Sanematsu F,Sato T,Uruno T,Duan X,Tomino T,Harada Y,Watanabe M,Wang Y,Tanaka Y,Nakanishi Y,Suyama M,Yoshinori F
53-5934 was used in Flow cytometry/Cell sorting to study the regulation of Aire expression in medullary thymic epithelial cells.
Wed Nov 04 00:00:00 EST 2015
The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.
Nature immunology
Waterfield M,Khan IS,Cortez JT,Fan U,Metzger T,Greer A,Fasano K,Martinez-Llordella M,Pollack JL,Erle DJ,Su M,Anderson MS
Published figure using AIRE monoclonal antibody (Product # 53-5934-82) in Flow Cytometry
Sat Mar 01 00:00:00 EST 2014
The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.
Nature immunology
Waterfield M,Khan IS,Cortez JT,Fan U,Metzger T,Greer A,Fasano K,Martinez-Llordella M,Pollack JL,Erle DJ,Su M,Anderson MS
Published figure using AIRE monoclonal antibody (Product # 53-5934-82) in Flow Cytometry
Sat Mar 01 00:00:00 EST 2014
An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
White AJ,Jenkinson WE,Cowan JE,Parnell SM,Bacon A,Jones ND,Jenkinson EJ,Anderson G
53-5934 was used in Flow cytometry/Cell sorting to investigate whether thymus microenvironments are required in iNKT cell development, showing that medullary thymic epithelial cells are essential for intrathymic development of iNKT cells.
Sat Mar 15 00:00:00 EDT 2014
Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway.
The Journal of experimental medicine
Coquet JM,Ribot JC,Bąbała N,Middendorp S,van der Horst G,Xiao Y,Neves JF,Fonseca-Pereira D,Jacobs H,Pennington DJ,Silva-Santos B,Borst J
53-5934 was used in Flow cytometry/Cell sorting to investigate how mTECs and DCs form dedicated niches in the thymic medulla, in which CD27-CD70 co-stimulation rescues developing Treg cells from apoptosis.
Mon Apr 08 00:00:00 EDT 2013
Generation of both cortical and Aire(+) medullary thymic epithelial compartments from CD205(+) progenitors.
European journal of immunology
Baik S,Jenkinson EJ,Lane PJ,Anderson G,Jenkinson WE
53-5934 was used in Flow cytometry/Cell sorting to reveal an unexpected overlap in the phenotypic properties of bipotent TECs with their lineage-restricted counterparts.
Fri Mar 01 00:00:00 EST 2013
Generation of both cortical and Aire(+) medullary thymic epithelial compartments from CD205(+) progenitors.
European journal of immunology
Baik S,Jenkinson EJ,Lane PJ,Anderson G,Jenkinson WE
53-5934 was used in Flow cytometry/Cell sorting to reveal an unexpected overlap in the phenotypic properties of bipotent TECs with their lineage-restricted counterparts.
Fri Mar 01 00:00:00 EST 2013
Three-dimensional visualization of the mouse thymus organization in health and immunodeficiency.
Journal of immunology (Baltimore, Md. : 1950)
Irla M,Guenot J,Sealy G,Reith W,Imhof BA,Sergé A
53-5934 was used in Flow cytometry/Cell sorting to develop an automated method for full organ reconstruction in three dimensions, allowing visualization of intact mouse lymphoid organs from a collection of immunolabeled slices.
Tue Jan 15 00:00:00 EST 2013
RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla.
The Journal of experimental medicine
Rossi SW,Kim MY,Leibbrandt A,Parnell SM,Jenkinson WE,Glanville SH,McConnell FM,Scott HS,Penninger JM,Jenkinson EJ,Lane PJ,Anderson G
Published figure using AIRE monoclonal antibody (Product # 53-5934-82) in Immunofluorescence
Mon Jun 11 00:00:00 EDT 2007
