Invitrogen

CD117 (c-Kit) Monoclonal Antibody (ACK2), APC, eBioscience™

20 Published Figures

37 References

View all (212) c-Kit (CD117) antibodies

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Datasheet

Protocols

Questions & Answers

Antibody Testing Data (1)
Published Figures (20)

CD117 (c-Kit) Antibody in Flow Cytometry (Flow)

FIGURE: 1 / 21

CD117 (c-Kit) Antibody (17-1172-82) in Flow

Staining of C57BL/6 bone marrow cells with Anti-Human/Mouse CD45R (B220) FITC (Product # 11-0452-82) and 0.03 µg of Rat IgG2b K Isotype Control APC (Product # 17-4031-82) (left) or 0.03 µg of Anti-Mouse CD117 (c-Kit) APC (right). Total viable cells were used for analysis.

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Product Details

17-1172-82

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Flow Cytometry (Flow)

0.06 µg/test

View 35 publications 35 publications

Functional Assay (Functional)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Mouse

Published species

Human, Mouse

Host/Isotype

Rat / IgG2b, kappa

Recommended Isotype Control

Rat IgG2b kappa Isotype Control (eB149/10H5), APC, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

ACK2

Conjugate

APC APC APC

Excitation/Emission Max

651/660 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_469433

Product Specific Information

Description: The ACK2 monoclonal antibody reacts with mouse CD117, also known as c-Kit receptor, Steel factor receptor and stem cell factor receptor. A member of the tyrosine kinase receptor family, this 145 kDa molecule is expressed by a majority of hematopoietic progenitor cells characterized in the mouse bone marrow as a small subset of cells positive for Sca-1 and Thy1 (Thy1^lo) and negative for lineage markers. The interaction of the mouse c-kit receptor and steel factor promotes the proliferation and differentiation of hematopoietic progenitor cells. CD117 is also expressed by mast cells and plays a role in signaling and activation of these cells. ACK2 has been reported to be a blocking antibody.

Applications Reported: The ACK2 antibody has been reported for use in flow cytometric analysis.

Applications Tested: The ACK2 antibody has been tested by flow cytometric analysis of mouse bone marrow cells. This can be used at less than or equal to 0.06 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth. c-Kit is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor. This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT. c-kit receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

Engineered bone marrow as a clinically relevant ex vivo model for primary bone cancer research and drug screening.

Proceedings of the National Academy of Sciences of the United States of America

Griffin KH,Thorpe SW,Sebastian A,Hum NR,Coonan TP,Sagheb IS,Loots GG,Randall RL,Leach JK

Published figure using CD117 (c-Kit) monoclonal antibody (Product # 17-1172-82) in Flow Cytometry

Tue Sep 26 00:00:00 EDT 2023

Landscape of mast cell populations across organs in mice and humans.

The Journal of experimental medicine

Tauber M,Basso L,Martin J,Bostan L,Pinto MM,Thierry GR,Houmadi R,Serhan N,Loste A,Blériot C,Kamphuis JBJ,Grujic M,Kjellén L,Pejler G,Paul C,Dong X,Galli SJ,Reber LL,Ginhoux F,Bajenoff M,Gentek R,Gaudenzio N

Published figure using CD117 (c-Kit) monoclonal antibody (Product # 17-1172-82) in Flow Cytometry

Mon Oct 02 00:00:00 EDT 2023

Gasdermin D inhibition ameliorates neutrophil mediated brain damage in acute ischemic stroke.

Cell death discovery

Hu R,Liang J,Ding L,Zhang W,Wang Y,Zhang Y,Zhang D,Pei L,Liu X,Xia Z,Xu Y,Song B

17-1172-82 was used in Flow cytometry/Cell sorting to provide a new viewpoint on the immunological modulation of neutrophils after MCAO and suggest that suppression of GSDMD may relieve the neuroinflammatory load, thereby providing a potential treatment strategy for stroke.

Wed Feb 08 00:00:00 EST 2023

Cellular taxonomy of Hic1⁺ mesenchymal progenitor derivatives in the limb: from embryo to adult.

Nature communications

Arostegui M,Scott RW,Böse K,Underhill TM

17-1172-82 was used in Flow cytometry/Cell sorting to describe the embryonic origin of appendicular Hic1+ MPs and demonstrate that they arise in the hypaxial somite, and migrate into the developing limb at embryonic day 11.5, well after limb bud initiation.

Thu Aug 25 00:00:00 EDT 2022

The AML-associated K313 mutation enhances C/EBPα activity by leading to C/EBPα overexpression.

Cell death & disease

Gentle IE,Moelter I,Badr MT,Döhner K,Lübbert M,Häcker G

Published figure using CD117 (c-Kit) monoclonal antibody (Product # 17-1172-82) in Flow Cytometry

Mon Jul 05 00:00:00 EDT 2021

The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function.

Haematologica

Brown A,Schuetz D,Han Y,Daria D,Nattamai KJ,Eiwen K,Sakk V,Pospiech J,Saller T,van Zant G,Wagner W,Geiger H

Published figure using CD117 (c-Kit) monoclonal antibody (Product # 17-1172-82) in Flow Cytometry

Tue Apr 27 00:00:00 EDT 2021

The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.

Nature communications

Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ

17-1172 was used in Flow cytometry/Cell sorting to show that disruption of the Gdpd3 gene encoding a lysophospholipase D enzyme decreases the self-renewal capacity of murine chronic myelogenous leukaemia stem cells.

Thu Sep 17 00:00:00 EDT 2020

The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.

Nature communications

Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ

Thu Sep 17 00:00:00 EDT 2020

Loss of Tet2 affects platelet function but not coagulation in mice.

Blood science (Baltimore, Md.)

Wang B,Xia M,Chen T,Li M,Shi D,Wang X,Pang A,Zhou J,Yuan W,Chu Y

17-1172-82 was used in Flow Cytometry to indicate that Tet2 deficiency leads to mild impairment of platelet function and thrombopoiesis in mice.

Thu Oct 01 00:00:00 EDT 2020

m6A RNA methylation impacts fate choices during skin morphogenesis.

eLife

Xi L,Carroll T,Matos I,Luo JD,Polak L,Pasolli HA,Jaffrey SR,Fuchs E

17-1172 was used in Flow cytometry/Cell sorting to study mouse skin embryogenesis to tackle m6A's functions and physiological importance.

Wed Aug 26 00:00:00 EDT 2020

Use of Busulfan to Condition Mice for Bone Marrow Transplantation.

STAR protocols

Montecino-Rodriguez E,Dorshkind K

17-1172 was used in Flow cytometry/Cell sorting to describe a protocol for the use of busulfan to condition mice for bone marrow transplantation and several of the variables to consider for effective implementation.

Fri Dec 18 00:00:00 EST 2020

Loss of FGFR3 Delays Acute Myeloid Leukemogenesis by Programming Weakly Pathogenic CD117-Positive Leukemia Stem-Like Cells.

Frontiers in pharmacology

Guo C,Ran Q,Sun C,Zhou T,Yang X,Zhang J,Pang S,Xiao Y

17-1172-82 was used in Flow Cytometry to find that FGFR3 had a novel regulatory mechanism for the stemness of LSCs in AML, and provided a promising anti-leukemia approach by interrupting FGFR3.

Tue Feb 16 00:00:00 EST 2021

Loss of FGFR3 Delays Acute Myeloid Leukemogenesis by Programming Weakly Pathogenic CD117-Positive Leukemia Stem-Like Cells.

Frontiers in pharmacology

Guo C,Ran Q,Sun C,Zhou T,Yang X,Zhang J,Pang S,Xiao Y

17-1172-82 was used in Flow Cytometry to find that FGFR3 had a novel regulatory mechanism for the stemness of LSCs in AML, and provided a promising anti-leukemia approach by interrupting FGFR3.

Tue Feb 16 00:00:00 EST 2021

Chimeric antigen receptor-induced BCL11B suppression propagates NK-like cell development.

The Journal of clinical investigation

Maluski M,Ghosh A,Herbst J,Scholl V,Baumann R,Huehn J,Geffers R,Meyer J,Maul H,Eiz-Vesper B,Krueger A,Schambach A,van den Brink MR,Sauer MG

17-1172-82 was used in Flow Cytometry to show that chimeric antigen receptor (CAR) expression during early phases of ex vivo generation of lymphoid progenitors suppressed BCL11B, leading to suppression of T cell-associated gene expression and acquisition of NK cell-like properties.

Mon Dec 02 00:00:00 EST 2019

Rate of Progression through a Continuum of Transit-Amplifying Progenitor Cell States Regulates Blood Cell Production.

Developmental cell

Li H,Natarajan A,Ezike J,Barrasa MI,Le Y,Feder ZA,Yang H,Ma C,Markoulaki S,Lodish HF

17-1172 was used in Flow cytometry/Cell sorting to show that glucocorticoids enhance erythrocyte production by slowing the rate of progression through this developmental continuum of transit-amplifying progenitors, permitting more cell divisions prior to terminal erythroid differentiation.

Mon Apr 08 00:00:00 EDT 2019

MicroRNA-21 is Required for Hematopoietic Cell Viability After Radiation Exposure.

International journal of radiation oncology, biology, physics

Puccetti MV,Adams CM,Dan TD,Palagani A,Simone BA,DeAngelis T,Eischen CM,Simone NL

17-1172 was used in Flow cytometry/Cell sorting to identify miR-21 as a critical component of HSPC viability and essential for bone marrow recovery following irradiation. Further investigation is warranted to determine whether miR-21 can be used to stratify patients at risk for hematopoietic toxicity following irradiation.

Thu Aug 01 00:00:00 EDT 2019

Lack of Cardiac Improvement After Cardiosphere-Derived Cell Transplantation in Aging Mouse Hearts.

Circulation research

Zhao ZA,Han X,Lei W,Li J,Yang Z,Wu J,Yao M,Lu XA,He L,Chen Y,Zhou B,Hu S

17-1172 was used in Flow cytometry/Cell sorting to evaluate the effect of cardiosphere-derived cell injection on an ageing heart.

Fri Oct 26 00:00:00 EDT 2018

c-Kit⁺ Cells in Adult Salivary Glands do not Function as Tissue Stem Cells.

Scientific reports

Kwak M,Ninche N,Klein S,Saur D,Ghazizadeh S

17-1172 was used in Flow cytometry/Cell sorting to study whether c-Kit is a reliable marker for salivary gland stem cells.

Fri Sep 21 00:00:00 EDT 2018

Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia.

Cancer cell

Reyna DE,Garner TP,Lopez A,Kopp F,Choudhary GS,Sridharan A,Narayanagari SR,Mitchell K,Dong B,Bartholdy BA,Walensky LD,Verma A,Steidl U,Gavathiotis E

17-1172 was used in Flow cytometry/Cell sorting to identify BTSA1, a pharmacologically optimised BAX activator that binds with high affinity and specificity to the N-terminal activation site and induces conformational changes to BAX leading to BAX-mediated apoptosis.

Mon Oct 09 00:00:00 EDT 2017

GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis.

The Journal of clinical investigation

Géraud C,Koch PS,Zierow J,Klapproth K,Busch K,Olsavszky V,Leibing T,Demory A,Ulbrich F,Diett M,Singh S,Sticht C,Breitkopf-Heinlein K,Richter K,Karppinen SM,Pihlajaniemi T,Arnold B,Rodewald HR,Augustin HG,Schledzewski K,Goerdt S

Published figure using CD117 (c-Kit) monoclonal antibody (Product # 17-1172-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Low Testosterone Alters the Activity of Mouse Prostate Stem Cells.

The Prostate

Zhou Y,Copeland B,Otto-Duessel M,He M,Markel S,Synold TW,Jones JO

Published figure using CD117 (c-Kit) monoclonal antibody (Product # 17-1172-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2017

A Functional Bioluminescent Zebrafish Screen for Enhancing Hematopoietic Cell Homing.

Stem cell reports

Astuti Y,Kramer AC,Blake AL,Blazar BR,Tolar J,Taisto ME,Lund TC

Published figure using CD117 (c-Kit) monoclonal antibody (Product # 17-1172-82) in Flow Cytometry

Tue Jan 10 00:00:00 EST 2017

Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome.

Nature communications

Shirai CL,White BS,Tripathi M,Tapia R,Ley JN,Ndonwi M,Kim S,Shao J,Carver A,Saez B,Fulton RS,Fronick C,O'Laughlin M,Lagisetti C,Webb TR,Graubert TA,Walter MJ

Published figure using CD117 (c-Kit) monoclonal antibody (Product # 17-1172-82) in Flow Cytometry

Mon Jan 09 00:00:00 EST 2017

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.

Cell

Puram RV,Kowalczyk MS,de Boer CG,Schneider RK,Miller PG,McConkey M,Tothova Z,Tejero H,Heckl D,Järås M,Chen MC,Li H,Tamayo A,Cowley GS,Rozenblatt-Rosen O,Al-Shahrour F,Regev A,Ebert BL

17-1172 was used in Flow cytometry/Cell sorting to identify essential transcription factors in a murine model of acute myeloid leukemia with genetically and phenotypically defined leukaemia stem cells.

Thu Apr 07 00:00:00 EDT 2016

Novel oral transforming growth factor-β signaling inhibitor EW-7197 eradicates CML-initiating cells.

Cancer science

Naka K,Ishihara K,Jomen Y,Jin CH,Kim DH,Gu YK,Jeong ES,Li S,Krause DS,Kim DW,Bae E,Takihara Y,Hirao A,Oshima H,Oshima M,Ooshima A,Sheen YY,Kim SJ,Kim DK

17-1172 was used in Flow cytometry/Cell sorting to indicate that EW-7197 may be a promising candidate for a new combination therapeutic that can greatly benefit CML patients.

Mon Feb 01 00:00:00 EST 2016

Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs.

Nature communications

Lai M,Gonzalez-Martin A,Cooper AB,Oda H,Jin HY,Shepherd J,He L,Zhu J,Nemazee D,Xiao C

17-1172 was used in Flow cytometry/Cell sorting to examine the regulation B-cell development and tolerance by different members of the miR-17~92 family microRNAs.

Tue Aug 02 00:00:00 EDT 2016

Regulation of Reactive Oxygen Species and the Antioxidant Protein DJ-1 in Mastocytosis.

PloS one

Kim DK,Beaven MA,Kulinski JM,Desai A,Bandara G,Bai Y,Prussin C,Schwartz LB,Komarow H,Metcalfe DD,Olivera A

17-1172 was used in Flow cytometry/Cell sorting to propose consideration of IL-6 blockade as a potential adjunctive therapy in the treatment of patients with advanced mastocytosis.

Fri Aug 04 00:00:00 EDT 2017

miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia.

Nature communications

Jiang X,Hu C,Arnovitz S,Bugno J,Yu M,Zuo Z,Chen P,Huang H,Ulrich B,Gurbuxani S,Weng H,Strong J,Wang Y,Li Y,Salat J,Li S,Elkahloun AG,Yang Y,Neilly MB,Larson RA,Le Beau MM,Herold T,Bohlander SK,Liu PP,Zhang J,Li Z,He C,Jin J,Hong S,Chen J

17-1172 was used in Flow cytometry/Cell sorting to investigate the anti-tumourigenic role of miR-22, showing that it has an anti-tumour role in acute myeloid leukaemia.

Tue Apr 26 00:00:00 EDT 2016

Characterisation of Neutropenia-Associated Neutrophil Elastase Mutations in a Murine Differentiation Model In Vitro and In Vivo.

PloS one

Wiesmeier M,Gautam S,Kirschnek S,Häcker G

17-1172 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms for neutrophil survival and maturation defects caused by mutant neutrophil elastase protein.

Wed Jun 28 00:00:00 EDT 2017

Characterisation of Neutropenia-Associated Neutrophil Elastase Mutations in a Murine Differentiation Model In Vitro and In Vivo.

PloS one

Wiesmeier M,Gautam S,Kirschnek S,Häcker G

17-1172 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms for neutrophil survival and maturation defects caused by mutant neutrophil elastase protein.

Wed Jun 28 00:00:00 EDT 2017

Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors.

Nature communications

Cheng H,Ang HY,A El Farran C,Li P,Fang HT,Liu TM,Kong SL,Chin ML,Ling WY,Lim EK,Li H,Huber T,Loh KM,Loh YH,Lim B

17-1172 was used in Immunocytochemistry to demonstrate how it is possible to reprogram mouse embryonic fibroblasts into engraftable blood progenitors.

Mon Nov 21 00:00:00 EST 2016

Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors.

Nature communications

Cheng H,Ang HY,A El Farran C,Li P,Fang HT,Liu TM,Kong SL,Chin ML,Ling WY,Lim EK,Li H,Huber T,Loh KM,Loh YH,Lim B

17-1172 was used in Immunocytochemistry to demonstrate how it is possible to reprogram mouse embryonic fibroblasts into engraftable blood progenitors.

Mon Nov 21 00:00:00 EST 2016

Dipeptide species regulate p38MAPK-Smad3 signalling to maintain chronic myelogenous leukaemia stem cells.

Nature communications

Naka K,Jomen Y,Ishihara K,Kim J,Ishimoto T,Bae EJ,Mohney RP,Stirdivant SM,Oshima H,Oshima M,Kim DW,Nakauchi H,Takihara Y,Kato Y,Ooshima A,Kim SJ

17-1172 was used in Flow cytometry/Cell sorting to investigate how survival signalling is regulated in chronic myelogenous leukaemia stem cells, showing that dipeptide species regulate p38MAPK-Smad3 signalling to maintain stem cells.

Thu Aug 20 00:00:00 EDT 2015

Contribution of mast cell-derived interleukin-1β to uric acid crystal-induced acute arthritis in mice.

Arthritis & rheumatology (Hoboken, N.J.)

Reber LL,Marichal T,Sokolove J,Starkl P,Gaudenzio N,Iwakura Y,Karasuyama H,Schwartz LB,Robinson WH,Tsai M,Galli SJ

17-1172 was used in Flow cytometry/Cell sorting to assess the role of mast cells in a mouse model of monosodium urate monohydrate crystal-induced acute arthritis.

Wed Oct 01 00:00:00 EDT 2014

The nucleotide sugar UDP-glucose mobilizes long-term repopulating primitive hematopoietic cells.

The Journal of clinical investigation

Kook S,Cho J,Lee SB,Lee BC

17-1172 was used in Flow cytometry/Cell sorting to demonstrate a novel mechanism governing the migration of haematopoietic stem progenitor cells under stress.

Thu Aug 01 00:00:00 EDT 2013

TRPA1-dependent pruritus in IL-13-induced chronic atopic dermatitis.

Journal of immunology (Baltimore, Md. : 1950)

Oh MH,Oh SY,Lu J,Lou H,Myers AC,Zhu Z,Zheng T

Published figure using CD117 (c-Kit) monoclonal antibody (Product # 17-1172-82) in Flow Cytometry

Sun Dec 01 00:00:00 EST 2013

Cells derived from the coelomic epithelium contribute to multiple gastrointestinal tissues in mouse embryos.

PloS one

Carmona R,Cano E,Mattiotti A,Gaztambide J,Muñoz-Chápuli R

17-1172 was used in Flow cytometry/Cell sorting to investigate the contribution of coelomic epithelium-derived cells to the intestinal development, showing that they contribute to multiple gastrointestinal tissues in mouse embryos.

Fri Aug 09 00:00:00 EDT 2013

Host-derived pericytes and Sca-1+ cells predominate in the MART-1- stroma fraction of experimentally induced melanoma.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Treviño-Villarreal JH,Cotanche DA,Sepúlveda R,Bortoni ME,Manneberg O,Udagawa T,Rogers RA

17-1172 was used in Flow cytometry/Cell sorting to suggest that pericytes and Sca-1+ stroma cells are important contributors to melanoma development.

Thu Dec 01 00:00:00 EST 2011

Chemokine receptor CXCR5 supports solitary intestinal lymphoid tissue formation, B cell homing, and induction of intestinal IgA responses.

Journal of immunology (Baltimore, Md. : 1950)

Velaga S,Herbrand H,Friedrichsen M,Jiong T,Dorsch M,Hoffmann MW,Förster R,Pabst O

17-1172 was used in Flow cytometry/Cell sorting to study the fate of individual solitary intestinal lymphoid tissue, and analyse its formation and function in CXCR5-deficient mice.

Sun Mar 01 00:00:00 EST 2009

Stable form of JAB1 enhances proliferation and maintenance of hematopoietic progenitors.

The Journal of biological chemistry

Mori M,Yoneda-Kato N,Yoshida A,Kato JY

17-1172 was used in Flow cytometry/Cell sorting to investigate how the expression and function of JAB1 are critical for the proliferation and maintenance of hematopoietic progenitors.

Fri Oct 24 00:00:00 EDT 2008

Bioinformatics

Protein Aliases: belly-spot; c-kit proto-oncogene protein; CD117; ckit; dominant spotting; Dominant white spotting; Mast/stem cell growth factor receptor Kit; Proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; SCFR; spotted sterile male; Steel Factor Receptor; Tyrosine-protein kinase Kit

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Gene Aliases: Bs; c-KIT; CD117; Fdc; Gsfsco1; Gsfsco5; Gsfsow3; Kit; SCO1; SCO5; Sl; SOW3; Ssm; Tr-kit; W

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UniProt ID: (Mouse) P05532

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Entrez Gene ID: (Mouse) 16590

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Function(s)

nucleotide binding protease binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity stem cell factor receptor activity protein binding ATP binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups cytokine binding protein homodimerization activity metal ion binding transmembrane signal receptor

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD117 (c-Kit) Monoclonal Antibody (ACK2), APC, eBioscience™

CD117 (c-Kit) Antibody (17-1172-82) in Flow

Product Details

17-1172-82

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Functional Assay (Functional)

Species Reactivity

Published species

Host/Isotype

Recommended Isotype Control

Class

Type

Clone

Conjugate

Excitation/Emission Max

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

How to use the Panel Builder

Bioinformatics

Performance Guarantee

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