Invitrogen

CD11b Monoclonal Antibody (M1/70), PE, eBioscience™

Advanced Verification

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

97 Published Figures

537 References

View all (223) CD11b antibodies

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Datasheet

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CD11b Antibody (12-0112-82) in Flow

Staining of mouse bone marrow cells with 0.06 µg of Rat IgG2b K Isotype Control PE (Product # 12-4031-82) (blue histogram) or 0.06 µg of Anti-Mouse CD11b PE (purple histogram). Cells in the large scatter population were used for analysis.

Product Image Gallery

CD11b Antibody — Figure 2 EP induces differentiation of leukemia cell lines. (A) Representative morphology of HL60 cells treated for 72 hours without EP, with EP, or with TPO shown at 20× (left panel) and 63× (right panel). Cells treated with EP portray reorganization of the nuclear contents compared with untreated cells (red arrows) and cells treated with TPO. (B) The fold change of FACS MFI ± SD (n = 3) of CD11B expression (i) and CD14 (ii) in HL60 cells treated with the above conditions relative to untreated cells for 72 hours. *P < .05; **P < .01; ***P < .001. FACS analysis of CD11B expression (iii) in untreated HL60 cells (blue line) versus cells treated with 5 µg/mL of EP (orange line) for 72 hours. FACS analysis of CD14 expression (iv) in untreated HL60 cells (green line) versus cells treated with 5 µg/mL of EP (orange line) for 72 hours. CD11B and CD14 are overexpressed with EP treatment. (C) Representative morphology of U937 cells and URE cells treated for 72 hours under the above conditions. U937 cells treated with EP demonstrate increased size with increased vacuoles in the cytoplasm. (D) The fold change of FACS MFI ± SD (n = 3) of CD11B expression in U937 cells and URE cells treated with or without EP for 72 hours. *P < .05; **P < .01. {TM}

Product Details

12-0112-82

Applications

Tested Dilution

Publications

Western Blot (WB)

View 1 publication 1 publication

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Frozen) (IHC (F))

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Flow Cytometry (Flow)

0.125 µg/test

View 527 publications 527 publications

In vitro Assay (IV)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Mouse

Published species

Dog, Fish, Human, Mouse

Host/Isotype

Rat / IgG2b, kappa

Recommended Isotype Control

Rat IgG2b kappa Isotype Control (eB149/10H5), PE, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

M1/70

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2734869

Product Specific Information

Description: The M1/70 monoclonal antibody reacts with mouse CD11b, the 165-170 kDa integrin alphaM. CD11b non-covalently associates with CD18 to form alphaMbeta2 integrin (Mac-1) and binds to CD54 (ICAM-1), C3bi, and fibrinogen. Mac-1 is expressed by macrophages, NK cells, granulocytes, activated lymphocytes and mouse B-1 cells in the peritoneal cavity. M1/70 is also cross-reactive to human CD11b, and can be used for the detection of this antigen on human peripheral blood monocytes, granulocytes, and a subset of NK cells. Through interactions with its ligands, CD11b participates in adhesive cell interactions.

Applications Reported: The M1/70 antibody has been reported for use in flow cytometric analysis.

Applications Tested: The M1/70 antibody has been tested by flow cytometric analysis of mouse splenocytes or bone marrow cells. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, a subset of dendritic cells, and microglia in the brain. CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X -these adhesions are critical for cell-cell and cell-matrix interactions. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Further, peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Diseases associated with CD11b dysfunction include systemic lupus erythematosus 6 and ITGAM-related susceptibility to systemic lupus erythematosus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

Deciphering the mechanism of Peptostreptococcus anaerobius-induced chemoresistance in colorectal cancer: the important roles of MDSC recruitment and EMT activation.

Frontiers in immunology

Gu J,Lv X,Li W,Li G,He X,Zhang Y,Shi L,Zhang X

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Oct 03 00:00:00 EDT 2023

Exogenous IL-10 posttreatment along with TLR4 and TNFR1 blockade improves tissue antioxidant status by modulating sepsis-induced macrophage polarization.

Journal of applied toxicology : JAT

Sawoo R,Dey R,Ghosh R,Bishayi B

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Sun Oct 01 00:00:00 EDT 2023

Gene deletion of long-chain acyl-CoA synthetase 4 attenuates xenobiotic chemical-induced lung injury via the suppression of lipid peroxidation.

Redox biology

Tomitsuka Y,Imaeda H,Ito H,Asou I,Ohbayashi M,Ishikawa F,Kuwata H,Hara S

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Sun Oct 01 00:00:00 EDT 2023

Intranasal Delivery of Endothelial Cell-Derived Extracellular Vesicles with Supramolecular Gel Attenuates Myocardial Ischemia-Reperfusion Injury.

International journal of nanomedicine

Wang J,Tan Y,Dai Y,Hu K,Tan X,Jiang S,Li G,Zhang X,Kang L,Wang X,Xu B

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Oct 05 00:00:00 EDT 2023

The Cxcr2⁺ subset of the S100a8⁺ gastric granylocytic myeloid-derived suppressor cell population (G-MDSC) regulates gastric pathology.

Frontiers in immunology

Kao KD,Grasberger H,El-Zaatari M

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Sep 29 00:00:00 EDT 2023

Non-Oncogene Addiction of KRAS-Mutant Cancers to IL-1β via Versican and Mononuclear IKKβ.

Cancers

Spella M,Ntaliarda G,Skiadas G,Lamort AS,Vreka M,Marazioti A,Lilis I,Bouloukou E,Giotopoulou GA,Pepe MAA,Weiss SAI,Petrera A,Hauck SM,Koch I,Lindner M,Hatz RA,Behr J,Arendt KAM,Giopanou I,Brunn D,Savai R,Jenne DE,de Château M,Yull FE,Blackwell TS,Stathopoulos GT

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Mar 20 00:00:00 EDT 2023

Targeting adrenergic receptors to mitigate invariant natural killer T cells-induced acute liver injury.

iScience

Gonzatti MB,Freire BM,Antunes MM,de Menezes GB,Talbot J,Peron JPS,Basso AS,Keller AC

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Oct 20 00:00:00 EDT 2023

Targeting adrenergic receptors to mitigate invariant natural killer T cells-induced acute liver injury.

iScience

Gonzatti MB,Freire BM,Antunes MM,de Menezes GB,Talbot J,Peron JPS,Basso AS,Keller AC

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Oct 20 00:00:00 EDT 2023

Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells.

Nature communications

Rožmanić C,Lisnić B,Pribanić Matešić M,Mihalić A,Hiršl L,Park E,Lesac Brizić A,Indenbirken D,Viduka I,Šantić M,Adler B,Yokoyama WM,Krmpotić A,Juranić Lisnić V,Jonjić S,Brizić I

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Oct 12 00:00:00 EDT 2023

LAL deficiency induced myeloid-derived suppressor cells as targets and biomarkers for lung cancer.

Journal for immunotherapy of cancer

Zhao T,Liu S,Hanna NH,Jalal S,Ding X,Wan J,Yan C,Du H

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

USP10 is a potential mediator for vagus nerve stimulation to alleviate neuroinflammation in ischaemic stroke by inhibiting NF-κB signalling pathway.

Frontiers in immunology

Xie C,Gao X,Liu G,Tang H,Li C

12-0112-82 was used in Flow cytometry/Cell sorting to investigate whether USP10 plays a key role in the protective effect of VNS against ischemic stroke and explore its mechanism.

Thu May 18 00:00:00 EDT 2023

Transmembrane protein 184B (TMEM184B) promotes expression of synaptic gene networks in the mouse hippocampus.

BMC genomics

Wright EB,Larsen EG,Coloma-Roessle CM,Hart HR,Bhattacharya MRC

12-0112-82 was used in Immunohistochemistry to suggest that TMEM184B is required for proper synaptic gene expression and anxiety-related behavior and is more likely to be linked to neurodevelopmental disorders than to dementia.

Wed Sep 20 00:00:00 EDT 2023

Loss of Anti-Tumor Efficacy by Polyamine Blocking Therapy in GCN2 Null Mice.

Biomedicines

Alexander ET,Fahey E,Phanstiel O,Gilmour SK

12-0112-82 was used in Flow Cytometry to suggest that polyamine-dependent GCN2 signaling in stromal cells promotes tumor growth and the development of the immunosuppressive tumor microenvironment, and that the PBT anti-tumor effect is mediated, at least in part, by targeting GCN2.

Thu Oct 05 00:00:00 EDT 2023

A plant-derived glucocorticoid receptor modulator with potency to attenuate the side effects of glucocorticoid therapy.

British journal of pharmacology

Wang Y,Gao J,Yu Y,Zhou L,Wang M,Xue W,Liu B,Wu X,Wu X,Gao H,Shen Y,Xu Q

12-0112-82 was used in flow cytometry to reveal that CA-e is a novel GR modulator with strong potency to attenuate the side effects of GC therapy and can be used as a potential molecular tool for deciphering GR signalling.

Sun Jan 01 00:00:00 EST 2023

Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis.

iScience

Zhou J,Wang H,Shu T,Wang J,Yang W,Li J,Ding L,Liu M,Sun H,Wong J,Lai PB,Tsang SW,Ward SE,Chow KL,Sung JJ,Sze-Lok Cheng A

12-0112-82 was used in Flow cytometry/Cell sorting to demonstrated that cell cycle-related kinase (CCRK) is upregulated in myeloid cells in tumor-bearing mice and in patients with hepatocellular carcinoma.

Fri Oct 20 00:00:00 EDT 2023

Inflammasome Coordinates Senescent Chronic Wound Induced by Thalassophryne nattereri Venom.

International journal of molecular sciences

Lima C,Andrade-Barros AI,Carvalho FF,Falcão MAP,Lopes-Ferreira M

12-0112-82 was used in Flow cytometry/Cell sorting to demonstrate in mouse paws injected with the venom the installation of γH2AX/p16Ink4a-dependent senescence with persistent neutrophilic inflammation in the proliferation and remodeling phases.

Mon May 08 00:00:00 EDT 2023

PAR4 Inhibition Reduces Coronary Artery Atherosclerosis and Myocardial Fibrosis in SR-B1/LDLR Double Knockout Mice.

Arteriosclerosis, thrombosis, and vascular biology

Lee SK,Malik RA,Zhou J,Wang W,Gross PL,Weitz JI,Ramachandran R,Trigatti BL

12-0112-82 was used in Flow Cytometry to identify PAR4 as an attractive target in reducing coronary artery disease development, and the use of RAG8 may potentially be beneficial in cardiovascular disease.

Wed Nov 01 00:00:00 EDT 2023

Topical Diacerein Decreases Skin and Splenic CD11c⁺ Dendritic Cells in Psoriasis.

International journal of molecular sciences

Brunner SM,Ramspacher A,Rieser C,Leitner J,Heil H,Ablinger M,Tevini J,Wimmer M,Koller A,Piñón Hofbauer J,Felder TK,Bauer JW,Kofler B,Lang R,Wally V

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Feb 21 00:00:00 EST 2023

Analysis of the Role of Stellate Cell VCAM-1 in NASH Models in Mice.

International journal of molecular sciences

Chung KJ,Legaki AI,Papadopoulos G,Gercken B,Gebler J,Schwabe RF,Chavakis T,Chatzigeorgiou A

12-0112-82 was used in Flow cytometry/Cell sorting to study the role of the pro-inflammatory adhesion molecule vascular cell adhesion molecule-1 (VCAM-1) in HSCs in NASH.

Thu Mar 02 00:00:00 EST 2023

CD11c⁺ microglia promote white matter repair after ischemic stroke.

Cell death & disease

Jia J,Zheng L,Ye L,Chen J,Shu S,Xu S,Bao X,Xia S,Liu R,Xu Y,Zhang M

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Feb 24 00:00:00 EST 2023

Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

Anti-PD-L1 antibody enhances curative effect of cryoablation via antibody-dependent cell-mediated cytotoxicity mediating PD-L1^highCD11b⁺ cells elimination in hepatocellular carcinoma.

Acta pharmaceutica Sinica. B

Tan J,Liu T,Fan W,Wei J,Zhu B,Liu Y,Liu L,Zhang X,Chen S,Lin H,Zhang Y,Li J

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2023

Oxygen-carrying nanoplatform to reprogram tumor immunosuppressive microenvironment and enhance photothermal-immunotherapy.

Materials today. Bio

Huang J,Leng X,Jiang T,Xu L,Zheng J,Fang M,Wang J,Wang Z,Zhang L

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2023

Combining gut microbiota modulation and chemotherapy by capecitabine-loaded prebiotic nanoparticle improves colorectal cancer therapy.

Nature communications

Lang T,Zhu R,Zhu X,Yan W,Li Y,Zhai Y,Wu T,Huang X,Yin Q,Li Y

12-0112-82 was used in In vitro Assay to create a prebiotic-based nanoparticle carrier for capecitabine, enhancing its anti-tumor efficacy in a colorectal cancer mouse model by modulating gut microbiota and increasing drug concentrations within tumors.

Mon Aug 07 00:00:00 EDT 2023

Long-term culture-expanded alveolar macrophages restore their full epigenetic identity after transfer in vivo.

Nature immunology

Subramanian S,Busch CJ,Molawi K,Geirsdottir L,Maurizio J,Vargas Aguilar S,Belahbib H,Gimenez G,Yuda RAA,Burkon M,Favret J,Gholamhosseinian Najjar S,de Laval B,Kandalla PK,Sarrazin S,Alexopoulou L,Sieweke MH

12-0112-82 was used in Flow Cytometry to study long-term mouse ex vivo alveolar macrophage gene expression and culture adaptations.

Tue Mar 01 00:00:00 EST 2022

Metabolic improvement and liver regeneration by inhibiting CXXC5 function for non-alcoholic steatohepatitis treatment.

Experimental & molecular medicine

Seo SH,Kim E,Yoon M,Lee SH,Park BH,Choi KY

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2022

Metabolic improvement and liver regeneration by inhibiting CXXC5 function for non-alcoholic steatohepatitis treatment.

Experimental & molecular medicine

Seo SH,Kim E,Yoon M,Lee SH,Park BH,Choi KY

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2022

Macrophages in epididymal adipose tissue secrete osteopontin to regulate bone homeostasis.

Nature communications

Dai B,Xu J,Li X,Huang L,Hopkins C,Wang H,Yao H,Mi J,Zheng L,Wang J,Tong W,Chow DH,Li Y,He X,Hu P,Chen Z,Zu H,Li Y,Yao Y,Jiang Q,Qin L

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Jan 20 00:00:00 EST 2022

PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation.

Nature communications

Schmid MC,Kang SW,Chen H,Paradise M,Ghebremedhin A,Kaneda MM,Chin SM,Do A,Watterson DM,Varner JA

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Apr 01 00:00:00 EDT 2022

Neutrophil-dendritic cell interaction plays an important role in live attenuated Leishmania vaccine induced immunity.

PLoS neglected tropical diseases

Bhattacharya P,Ismail N,Saxena A,Gannavaram S,Dey R,Oljuskin T,Akue A,Takeda K,Yu J,Karmakar S,Dagur PK,McCoy JP,Nakhasi HL

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Feb 01 00:00:00 EST 2022

TIM3 Expression in Anaplastic-Thyroid-Cancer-Infiltrating Macrophages: An Emerging Immunotherapeutic Target.

Biology

Palacios LM,Peyret V,Viano ME,Geysels RC,Chocobar YA,Volpini X,Pellizas CG,Nicola JP,Motran CC,Rodriguez-Galan MC,Fozzatti L

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Nov 03 00:00:00 EDT 2022

Comparative analysis of thoracic and abdominal aortic aneurysms across the segment and species at the single-cell level.

Frontiers in pharmacology

Wu H,Xie C,Wang R,Cheng J,Xu Q,Zhao H

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Feb 02 00:00:00 EST 2023

Comparative analysis of thoracic and abdominal aortic aneurysms across the segment and species at the single-cell level.

Frontiers in pharmacology

Wu H,Xie C,Wang R,Cheng J,Xu Q,Zhao H

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Feb 02 00:00:00 EST 2023

Microglial angiotensin type 2 receptors mediate sex-specific expression of inflammatory cytokines independently of circulating estrogen.

Glia

Garrido-Gil P,Pedrosa MA,Garcia-Garrote M,Pequeño-Valtierra A,Rodríguez-Castro J,García-Souto D,Rodríguez-Pérez AI,Labandeira-Garcia JL

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2022

Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity.

Nature communications

Franklin R,Guo Y,He S,Chen M,Ji F,Zhou X,Frankhouser D,Do BT,Chiem C,Jang M,Blanco MA,Vander Heiden MG,Rockne RC,Ninova M,Sykes DB,Hochedlinger K,Lu R,Sadreyev RI,Murn J,Volk A,Cheloufi S

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Apr 29 00:00:00 EDT 2022

Biocompatible reduced graphene oxide stimulated BMSCs induce acceleration of bone remodeling and orthodontic tooth movement through promotion on osteoclastogenesis and angiogenesis.

Bioactive materials

Jiao D,Wang J,Yu W,Zhang K,Zhang N,Cao L,Jiang X,Bai Y

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2022

ACSL4-dependent ferroptosis does not represent a tumor-suppressive mechanism but ACSL4 rather promotes liver cancer progression.

Cell death & disease

Grube J,Woitok MM,Mohs A,Erschfeld S,Lynen C,Trautwein C,Otto T

12-0112-82 was used in Flow cytometry/Cell sorting to investigate the role of ferroptosis, a type of programmed cell death involving iron-dependent peroxidation of membrane phospholipids, in liver cancer (hepatocellular carcinoma) using mouse models of chronic injury-dependent HCC formation.

Sat Aug 13 00:00:00 EDT 2022

Therapeutic effect of NLRP3 inhibition on hearing loss induced by systemic inflammation in a CAPS-associated mouse model.

EBioMedicine

Ma JH,Lee E,Yoon SH,Min H,Oh JH,Hwang I,Sung Y,Ryu JH,Bok J,Yu JW

12-0112-82 was used in Flow cytometry/Cell sorting to investigate whether Cryopyrin-associated periodic syndrome-associated mutation in NLRP3 is associated with the progression of hearing loss.

Mon Aug 01 00:00:00 EDT 2022

Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration.

Nature communications

Lin C,Yang Q,Guo D,Xie J,Yang YS,Chaugule S,DeSouza N,Oh WT,Li R,Chen Z,John AA,Qiu Q,Zhu LJ,Greenblatt MB,Ghosh S,Li S,Gao G,Haynes C,Emerson CP,Shim JH

12-0112-82 was used in Flow cytometry/Cell sorting to identify mitochondrial oxidative phosphorylation as the prominent energy-driving force for osteogenesis of skeletal progenitors, governing musculoskeletal integrity.

Fri Nov 11 00:00:00 EST 2022

Chronic exposure to carbon black ultrafine particles reprograms macrophage metabolism and accelerates lung cancer.

Science advances

Chang CY,You R,Armstrong D,Bandi A,Cheng YT,Burkhardt PM,Becerra-Dominguez L,Madison MC,Tung HY,Zeng Z,Wu Y,Song L,Phillips PE,Porter P,Knight JM,Putluri N,Yuan X,Marcano DC,McHugh EA,Tour JM,Catic A,Maneix L,Burt BM,Lee HS,Corry DB,Kheradmand F

12-0112-82 was used in Flow Cytometry to promote immunosuppression and accelerates the development of lung cancer.

Fri Nov 18 00:00:00 EST 2022

Breast cancer cell-derived extracellular vesicles promote CD8⁺ T cell exhaustion via TGF-β type II receptor signaling.

Nature communications

Xie F,Zhou X,Su P,Li H,Tu Y,Du J,Pan C,Wei X,Zheng M,Jin K,Miao L,Wang C,Meng X,van Dam H,Ten Dijke P,Zhang L,Zhou F

12-0112-82 was used in Flow Cytometry to investigate TβRII and extracellular vesicle delivery in breast cancer to derive targets for immunotherapy.

Mon Aug 01 00:00:00 EDT 2022

Astrocyte immunometabolic regulation of the tumour microenvironment drives glioblastoma pathogenicity.

Brain : a journal of neurology

Perelroizen R,Philosof B,Budick-Harmelin N,Chernobylsky T,Ron A,Katzir R,Shimon D,Tessler A,Adir O,Gaoni-Yogev A,Meyer T,Krivitsky A,Shidlovsky N,Madi A,Ruppin E,Mayo L

12-0112-82 was used in Flow Cytometry to suggest that targeting astrocyte immunometabolic signalling may be useful in treating this uniformly lethal brain tumour.

Wed Sep 14 00:00:00 EDT 2022

Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction.

Nature communications

Klapproth E,Witt A,Klose P,Wiedemann J,Vavilthota N,Künzel SR,Kämmerer S,Günscht M,Sprott D,Lesche M,Rost F,Dahl A,Rauch E,Kattner L,Weber S,Mirtschink P,Kopaliani I,Guan K,Lorenz K,Saftig P,Wagner M,El-Armouche A

12-0112-82 was used in Flow cytometry/Cell sorting to demonstrate distinct role of (ADAM10)/CX3CL1 axis in the regulation of neutrophil recruitment early after MI towards improved prognosis.

Sat Dec 10 00:00:00 EST 2022

The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells.

Cell stem cell

Baker N,Wade S,Triolo M,Girgis J,Chwastek D,Larrigan S,Feige P,Fujita R,Crist C,Rudnicki MA,Burelle Y,Khacho M

12-0112-82 was used in Flow cytometry/Cell sorting to reveal a fundamental role for OPA1 and mitochondrial dynamics in establishing the quiescent state and activation potential of adult stem cells.

Thu Sep 01 00:00:00 EDT 2022

Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment.

Nature communications

Schneider KM,Mohs A,Gui W,Galvez EJC,Candels LS,Hoenicke L,Muthukumarasamy U,Holland CH,Elfers C,Kilic K,Schneider CV,Schierwagen R,Strnad P,Wirtz TH,Marschall HU,Latz E,Lelouvier B,Saez-Rodriguez J,de Vos W,Strowig T,Trebicka J,Trautwein C

12-0112-82 was used in Flow cytometry/Cell sorting to demonstrate that gut microbiota closely shapes the hepatic inflammatory microenvironment opening approaches for cancer prevention and therapy.

Fri Jul 08 00:00:00 EDT 2022

Loss of H2R Signaling Disrupts Neutrophil Homeostasis and Promotes Inflammation-Associated Colonic Tumorigenesis in Mice.

Cellular and molecular gastroenterology and hepatology

Shi Z,Mori-Akiyama Y,Du W,Fultz R,Zhao Y,Ruan W,Venable S,Engevik MA,Versalovic J

12-0112-82 was used in Flow Cytometry to demonstrate that blocking H2R signaling enhanced proinflammatory responses of mature neutrophils and suppressed neutrophil maturation, leading to accelerated progression of inflammation-associated colonic tumorigenesis.

Mon Apr 04 00:00:00 EDT 2022

Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19.

Cell host & microbe

Guo Q,Zhao Y,Li J,Liu J,Yang X,Guo X,Kuang M,Xia H,Zhang Z,Cao L,Luo Y,Bao L,Wang X,Wei X,Deng W,Wang N,Chen L,Chen J,Zhu H,Gao R,Qin C,Wang X,You F

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Feb 10 00:00:00 EST 2021

Multiple inducers and novel roles of autoantibodies against the obligatory NMDAR subunit NR1: a translational study from chronic life stress to brain injury.

Molecular psychiatry

Pan H,Steixner-Kumar AA,Seelbach A,Deutsch N,Ronnenberg A,Tapken D,von Ahsen N,Mitjans M,Worthmann H,Trippe R,Klein-Schmidt C,Schopf N,Rentzsch K,Begemann M,Wienands J,Stöcker W,Weissenborn K,Hollmann M,Nave KA,Lühder F,Ehrenreich H

12-0112 was used in Flow cytometry/Cell sorting to conclude that NMDAR1-AB may have a role as endogenous NMDAR antagonists, formed or boosted under various circumstances, ranging from genetic predisposition to, e.g., tumors, infection, brain injury, and stress, altogether increasing over lifetime, and exerting a spectrum of possible effects, also including beneficial functions.

Tue Jun 01 00:00:00 EDT 2021

Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin.

Cell death and differentiation

Velletri T,Huang Y,Wang Y,Li Q,Hu M,Xie N,Yang Q,Chen X,Chen Q,Shou P,Gan Y,Candi E,Annicchiarico-Petruzzelli M,Agostini M,Yang H,Melino G,Shi Y,Wang Y

12-0112 was used in Flow cytometry/Cell sorting to show by microCT that mice with p53 deletion systemically or specifically in mesenchymal cells possess significantly higher bone density than their respective littermate controls.

Fri Jan 01 00:00:00 EST 2021

Mice with a specific deficiency of Pfkfb3 in myeloid cells are protected from hypoxia-induced pulmonary hypertension.

British journal of pharmacology

Wang L,Zhang X,Cao Y,Ma Q,Mao X,Xu J,Yang Q,Zhou Y,Lucas R,Fulton DJ,Su Y,Barman SA,Hong M,Liu Z,Huo Y

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Mar 01 00:00:00 EST 2021

The effects of postmortem delay on mouse and human microglia gene expression.

Glia

Heng Y,Dubbelaar ML,Marie SKN,Boddeke EWGM,Eggen BJL

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Apr 01 00:00:00 EDT 2021

The effects of postmortem delay on mouse and human microglia gene expression.

Glia

Heng Y,Dubbelaar ML,Marie SKN,Boddeke EWGM,Eggen BJL

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Apr 01 00:00:00 EDT 2021

Intrinsic DNA damage repair deficiency results in progressive microglia loss and replacement.

Glia

Zhang X,Heng Y,Kooistra SM,van Weering HRJ,Brummer ML,Gerrits E,Wesseling EM,Brouwer N,Nijboer TW,Dubbelaar ML,Boddeke EWGM,Eggen BJL

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Mar 01 00:00:00 EST 2021

Intrinsic DNA damage repair deficiency results in progressive microglia loss and replacement.

Glia

Zhang X,Heng Y,Kooistra SM,van Weering HRJ,Brummer ML,Gerrits E,Wesseling EM,Brouwer N,Nijboer TW,Dubbelaar ML,Boddeke EWGM,Eggen BJL

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Mar 01 00:00:00 EST 2021

CD36 deficiency ameliorates drug-induced acute liver injury in mice.

Molecular medicine (Cambridge, Mass.)

Zhang C,Shi X,Su Z,Hu C,Mu X,Pan J,Li M,Teng F,Ling T,Zhao T,Xu C,Ji G,You Q

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Sun Jun 06 00:00:00 EDT 2021

Advanced maternal age induces fetal growth restriction through decreased placental inflammatory cytokine expression and immune cell accumulation in mice.

The Journal of reproduction and development

Hirata Y,Katsukura Y,Henmi Y,Ozawa R,Shimazaki S,Kurosawa A,Torii Y,Takahashi H,Iwata H,Kuwayama T,Shirasuna K

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Aug 27 00:00:00 EDT 2021

Advanced maternal age induces fetal growth restriction through decreased placental inflammatory cytokine expression and immune cell accumulation in mice.

The Journal of reproduction and development

Hirata Y,Katsukura Y,Henmi Y,Ozawa R,Shimazaki S,Kurosawa A,Torii Y,Takahashi H,Iwata H,Kuwayama T,Shirasuna K

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Aug 27 00:00:00 EDT 2021

Brd4 modulates diet-induced obesity via PPARγ-dependent Gdf3 expression in adipose tissue macrophages.

JCI insight

Hu X,Dong X,Li G,Chen Y,Chen J,He X,Sun H,Kim DH,Kemper JK,Chen LF

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Apr 08 00:00:00 EDT 2021

Polarization of Type 1 Macrophages Is Associated with the Severity of Viral Encephalitis Caused by Japanese Encephalitis Virus and Dengue Virus.

Cells

Jhan MK,Chen CL,Shen TJ,Tseng PC,Wang YT,Satria RD,Yu CY,Lin CF

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Nov 15 00:00:00 EST 2021

Pancreatic Cancer Chemotherapy Is Potentiated by Induction of Tertiary Lymphoid Structures in Mice.

Cellular and molecular gastroenterology and hepatology

Delvecchio FR,Fincham REA,Spear S,Clear A,Roy-Luzarraga M,Balkwill FR,Gribben JG,Bombardieri M,Hodivala-Dilke K,Capasso M,Kocher HM

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Mar 28 00:00:00 EDT 2022

Myeloid DJ-1 deficiency protects acetaminophen-induced acute liver injury through decreasing inflammatory response.

Aging

Wang B,Li J,Jiao J,Xu M,Luo Y,Wang F,Xia Q,Gao Y,Feng Y,Kong X,Sun X

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Jul 21 00:00:00 EDT 2021

Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway.

Nature communications

Fujino T,Goyama S,Sugiura Y,Inoue D,Asada S,Yamasaki S,Matsumoto A,Yamaguchi K,Isobe Y,Tsuchiya A,Shikata S,Sato N,Morinaga H,Fukuyama T,Tanaka Y,Fukushima T,Takeda R,Yamamoto K,Honda H,Nishimura EK,Furukawa Y,Shibata T,Abdel-Wahab O,Suematsu M,Kitamura T

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Mar 23 00:00:00 EDT 2021

In vitro and ex vivo evaluation of tumor-derived exosome-induced dendritic cell dysfunction in mouse.

STAR protocols

Zeng W,Yin X,Jiang Y,Jin L,Liang W

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Mar 19 00:00:00 EDT 2021

In vitro and ex vivo evaluation of tumor-derived exosome-induced dendritic cell dysfunction in mouse.

STAR protocols

Zeng W,Yin X,Jiang Y,Jin L,Liang W

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Mar 19 00:00:00 EDT 2021

Platelet-Like Fusogenic Liposome-Mediated Targeting Delivery of miR-21 Improves Myocardial Remodeling by Reprogramming Macrophages Post Myocardial Ischemia-Reperfusion Injury.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Tan H,Song Y,Chen J,Zhang N,Wang Q,Li Q,Gao J,Yang H,Dong Z,Weng X,Wang Z,Sun D,Yakufu W,Pang Z,Huang Z,Ge J

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Sun Aug 01 00:00:00 EDT 2021

Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40.

Nature communications

Yang F,He Z,Duan H,Zhang D,Li J,Yang H,Dorsey JF,Zou W,Nabavizadeh SA,Bagley SJ,Abdullah K,Brem S,Zhang L,Xu X,Byrne KT,Vonderheide RH,Gong Y,Fan Y

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Jun 08 00:00:00 EDT 2021

Mechanical Stress Induce PG-E2 in Murine Synovial Fibroblasts Originating from the Temporomandibular Joint.

Cells

Nazet U,Feulner L,Muschter D,Neubert P,Schatz V,Grässel S,Jantsch J,Proff P,Schröder A,Kirschneck C

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Electronic Cigarette Exposure Enhances Lung Inflammatory and Fibrotic Responses in COPD Mice.

Frontiers in pharmacology

Han H,Peng G,Meister M,Yao H,Yang JJ,Zou MH,Liu ZR,Ji X

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Sat Apr 02 00:00:00 EDT 2022

STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer.

Cellular and molecular gastroenterology and hepatology

Vonderhaar EP,Barnekow NS,McAllister D,McOlash L,Eid MA,Riese MJ,Tarakanova VL,Johnson BD,Dwinell MB

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Jan 24 00:00:00 EST 2022

Prevention of non-alcoholic steatohepatitis by long-term exercise via the induction of phenotypic changes in Kupffer cells of hyperphagic obese mice.

Physiological reports

Miura I,Komine S,Okada K,Wada S,Warabi E,Uchida F,Oh S,Suzuki H,Mizokami Y,Shoda J

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury.

Nature communications

Jin H,Liu K,Tang J,Huang X,Wang H,Zhang Q,Zhu H,Li Y,Pu W,Zhao H,He L,Li Y,Zhang S,Zhang Z,Zhao Y,Qin Y,Pflanz S,Kasmi KEI,Zhang W,Liu Z,Ginhoux F,Ji Y,He B,Wang L,Zhou B

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon May 17 00:00:00 EDT 2021

Desiccation Induced Conjunctival Monocyte Recruitment and Activation - Implications for Keratoconjunctivitis.

Frontiers in immunology

Alam J,de Paiva CS,Pflugfelder SC

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Dec 10 00:00:00 EST 2021

Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality.

Cell reports

Dang MT,Gonzalez MV,Gaonkar KS,Rathi KS,Young P,Arif S,Zhai L,Alam Z,Devalaraja S,To TKJ,Folkert IW,Raman P,Rokita JL,Martinez D,Taroni JN,Shapiro JA,Greene CS,Savonen C,Mafra F,Hakonarson H,Curran T,Haldar M

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Mar 30 00:00:00 EDT 2021

Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring.

PloS one

Ozen M,Zhao H,Kalish F,Yang Y,Jantzie LL,Wong RJ,Stevenson DK

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Nov 17 00:00:00 EST 2021

Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring.

PloS one

Ozen M,Zhao H,Kalish F,Yang Y,Jantzie LL,Wong RJ,Stevenson DK

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Nov 17 00:00:00 EST 2021

A Population of M2 Macrophages Associated With Bone Formation.

Frontiers in immunology

Olmsted-Davis E,Mejia J,Salisbury E,Gugala Z,Davis AR

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Dec 13 00:00:00 EST 2021

Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation.

Nature communications

Heil J,Olsavszky V,Busch K,Klapproth K,de la Torre C,Sticht C,Sandorski K,Hoffmann J,Schönhaber H,Zierow J,Winkler M,Schmid CD,Staniczek T,Daniels DE,Frayne J,Metzgeroth G,Nowak D,Schneider S,Neumaier M,Weyer V,Groden C,Gröne HJ,Richter K,Mogler C,Taketo MM,Schledzewski K,Géraud C,Goerdt S,Koch PS

12-0112-82 was used in Flow Cytometry to show that bone marrow sinusoidal endothelial cells actively control erythropoiesis.

Mon Nov 29 00:00:00 EST 2021

Intestinal CD11b⁺ B Cells Ameliorate Colitis by Secreting Immunoglobulin A.

Frontiers in immunology

Fu Y,Wang Z,Yu B,Lin Y,Huang E,Liu R,Zhao C,Lu M,Xu W,Liu H,Liu Y,Wang L,Chu Y

12-0112-82 was used in Flow Cytometry to demonstrate that CD11b+ B cells are essential intestinal suppressive immune cells and the primary source of intestinal IgA, which plays an indispensable role in maintaining intestinal homeostasis.

Fri Jan 07 00:00:00 EST 2022

Refractoriness of STING therapy is relieved by AKT inhibitor through effective vascular disruption in tumour.

Nature communications

Jeong SH,Yang MJ,Choi S,Kim J,Koh GY

12-0112-82 was used in Flow cytometry/Cell sorting to investigate Stimulator of Interferon Genes (STING) therapy in anti-tumour immunity.

Tue Jul 20 00:00:00 EDT 2021

Abraxane-induced bone marrow CD11b⁺ myeloid cell depletion in tumor-bearing mice is visualized by μPET-CT with ⁶⁴Cu-labeled anti-CD11b and prevented by anti-CSF-1.

Theranostics

Cao Q,Huang Q,Wang YA,Li C

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Jul 23 00:00:00 EDT 2021

Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis.

Journal of neuroinflammation

Chen YH,Eskandarpour M,Zhang X,Galatowicz G,Greenwood J,Lightman S,Calder V

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Feb 18 00:00:00 EST 2021

Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis.

Journal of neuroinflammation

Chen YH,Eskandarpour M,Zhang X,Galatowicz G,Greenwood J,Lightman S,Calder V

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Feb 18 00:00:00 EST 2021

Depletion of Retinal Dopaminergic Activity in a Mouse Model of Rod Dysfunction Exacerbates Experimental Autoimmune Uveoretinitis: A Role for the Gateway Reflex.

International journal of molecular sciences

Stofkova A,Zloh M,Andreanska D,Fiserova I,Kubovciak J,Hejda J,Kutilek P,Murakami M

12-0112-82 was used in Flow cytometry/Cell sorting to hypothesize that rod photoreceptor dysfunction causes remodeling of retinal neural activity, which influences the blood-retinal barrier and the development of retinal inflammation.

Fri Dec 31 00:00:00 EST 2021

Roles of lung-recruited monocytes and pulmonary Vascular Endothelial Growth Factor (VEGF) in resolving Ventilator-Induced Lung Injury (VILI).

PloS one

Lin CK,Huang TH,Yang CT,Shi CS

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Oct 12 00:00:00 EDT 2021

Systemic administration of β-glucan induces immune training in microglia.

Journal of neuroinflammation

Heng Y,Zhang X,Borggrewe M,van Weering HRJ,Brummer ML,Nijboer TW,Joosten LAB,Netea MG,Boddeke EWGM,Laman JD,Eggen BJL

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Feb 22 00:00:00 EST 2021

Systemic administration of β-glucan induces immune training in microglia.

Journal of neuroinflammation

Heng Y,Zhang X,Borggrewe M,van Weering HRJ,Brummer ML,Nijboer TW,Joosten LAB,Netea MG,Boddeke EWGM,Laman JD,Eggen BJL

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Feb 22 00:00:00 EST 2021

Photothermal therapy combined with neoantigen cancer vaccination for effective immunotherapy against large established tumors and distant metastasis.

Advanced therapeutics

Nam J,Son S,Park KS,Moon JJ

12-0112-82 was used in Flow cytometry/Cell sorting to conclude that PTT combined with neoantigen cancer vaccine is a promising nano-immunotherapy for personalized therapy of advanced cancer.

Sun Aug 01 00:00:00 EDT 2021

Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity.

Cell

Nguyen PT,Dorman LC,Pan S,Vainchtein ID,Han RT,Nakao-Inoue H,Taloma SE,Barron JJ,Molofsky AB,Kheirbek MA,Molofsky AV

12-0112-82 was used in Flow Cytometry to study a cellular mechanism through which microglia regulate experience-dependent synapse remodeling and promote memory consolidation.

Thu Jul 23 00:00:00 EDT 2020

Plasmacytoid Dendritic Cells and Type I Interferon Promote Extrafollicular B Cell Responses to Extracellular Self-DNA.

Immunity

Soni C,Perez OA,Voss WN,Pucella JN,Serpas L,Mehl J,Ching KL,Goike J,Georgiou G,Ippolito GC,Sisirak V,Reizis B

12-0112-82 was used in Flow Cytometry to establish extrafollicular B cell differentiation into short-lived AFCs as a key mechanism of anti-DNA autoreactivity and reveal a major contribution of pDCs, endosomal Toll-like receptors (TLRs), and IFN-I to this pathway.

Tue Jun 16 00:00:00 EDT 2020

Heterogenous Populations of Tissue-Resident CD8⁺ T Cells Are Generated in Response to Infection and Malignancy.

Immunity

Milner JJ,Toma C,He Z,Kurd NS,Nguyen QP,McDonald B,Quezada L,Widjaja CE,Witherden DA,Crowl JT,Shaw LA,Yeo GW,Chang JT,Omilusik KD,Goldrath AW

12-0112 was used in Flow cytometry/Cell sorting to identify discrete lineages of intestinal antigen-specific CD8+ T cells, including a Blimp1hiId3lo tissue-resident effector cell population most prominent in the early phase of acute viral and bacterial infections and a molecularly distinct Blimp1loId3hi tissue-resident memory population that subsequently accumulated at later infection time points.

Tue May 19 00:00:00 EDT 2020

Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity.

Immunity

Turner JA,Stephen-Victor E,Wang S,Rivas MN,Abdel-Gadir A,Harb H,Cui Y,Fanny M,Charbonnier LM,Fong JJH,Benamar M,Wang L,Burton OT,Bansal K,Bry L,Zhu C,Li QZ,Clement RL,Oettgen HC,Crestani E,Rachid R,Sage PT,Chatila TA

12-0112-82 was used in Flow Cytometry to show that Treg cells in food allergy (FA) had decreased expression of transforming growth factor beta 1 (TGF-β1) because of interleukin-4 (IL-4)- and signal transducer and activator of transciription-6 (STAT6)-dependent inhibition of Tgfb1 transcription.

Tue Dec 15 00:00:00 EST 2020

Salmonella Typhoid Toxin PltB Subunit and Its Non-typhoidal Salmonella Ortholog Confer Differential Host Adaptation and Virulence.

Cell host & microbe

Lee S,Yang YA,Milano SK,Nguyen T,Ahn C,Sim JH,Thompson AJ,Hillpot EC,Yoo G,Paulson JC,Song J

12-0112-82 was used in Flow Cytometry to demonstrate the differential effects of typhoid toxin and its nontyphoidal Salmonellae orthologue on varying clinical presentations.

Wed Jun 10 00:00:00 EDT 2020

RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.

Cell stem cell

Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J

12-0112-82 was used in Flow Cytometry to reveal crucial functions of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance and highlight the therapeutic potential of targeting the ALKBH5/m6A axis.

Thu Jul 02 00:00:00 EDT 2020

Dual-Wavelength Photosensitive Nano-in-Micro Scaffold Regulates Innate and Adaptive Immune Responses for Osteogenesis.

Nano-micro letters

Zhao Q,Shi M,Yin C,Zhao Z,Zhang J,Wang J,Shen K,Zhang L,Tang H,Xiao Y,Zhang Y

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Sat Nov 21 00:00:00 EST 2020

Long-term ex vivo expansion of mouse hematopoietic stem cells.

Nature protocols

Wilkinson AC,Ishida R,Nakauchi H,Yamazaki S

12-0112 was used in Flow cytometry/Cell sorting to describe a simple platform for the expansion of functional mouse hematopoietic stem cells ex vivo for >1 month under fully defined albumin-free conditions.

Sat Feb 01 00:00:00 EST 2020

Cellular and Molecular Mechanisms of Kidney Injury in 2,8-Dihydroxyadenine Nephropathy.

Journal of the American Society of Nephrology : JASN

Klinkhammer BM,Djudjaj S,Kunter U,Palsson R,Edvardsson VO,Wiech T,Thorsteinsdottir M,Hardarson S,Foresto-Neto O,Mulay SR,Moeller MJ,Jahnen-Dechent W,Floege J,Anders HJ,Boor P

12-0112 was used in Immunohistochemistry to assess the pathogenic sequelae of 2,8-DHA crystal-induced kidney damage.

Wed Apr 01 00:00:00 EDT 2020

IgE Contributes to Atherosclerosis and Obesity by Affecting Macrophage Polarization, Macrophage Protein Network, and Foam Cell Formation.

Arteriosclerosis, thrombosis, and vascular biology

Zhang X,Li J,Luo S,Wang M,Huang Q,Deng Z,de Febbo C,Daoui A,Liew PX,Sukhova GK,Metso J,Jauhiainen M,Shi GP,Guo J

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Sun Mar 01 00:00:00 EST 2020

Modulation of the functions of myeloid-derived suppressor cells : a new strategy of hydrogen sulfide anti-cancer effects.

British journal of pharmacology

De Cicco P,Ercolano G,Rubino V,Terrazzano G,Ruggiero G,Cirino G,Ianaro A

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Sat Feb 01 00:00:00 EST 2020

Periodontal inflammation recruits distant metastatic breast cancer cells by increasing myeloid-derived suppressor cells.

Oncogene

Cheng R,Billet S,Liu C,Haldar S,Choudhury D,Tripathi M,Hav M,Merchant A,Hu T,Huang H,Zhou H,Bhowmick NA

12-0112-82 was used in Flow cytometry to address the effect of periodontal inflammation (PI) on tumor progression, metastasis, and possible underlining mechanisms.

Sat Feb 01 00:00:00 EST 2020

Alpha-hemolysin of uropathogenic Escherichia coli induces GM-CSF-mediated acute kidney injury.

Mucosal immunology

Wang C,Li Q,Lv J,Sun X,Cao Y,Yu K,Miao C,Zhang ZS,Yao Z,Wang Q

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

Temporospatial distribution and transcriptional profile of retinal microglia in the oxygen-induced retinopathy mouse model.

Glia

Boeck M,Thien A,Wolf J,Hagemeyer N,Laich Y,Yusuf D,Backofen R,Zhang P,Boneva S,Stahl A,Hilgendorf I,Agostini H,Prinz M,Wieghofer P,Schlunck G,Schlecht A,Lange C

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2020

Characterization and regulation of osteoclast precursors following chronic Porphyromonas gingivalis infection.

Journal of leukocyte biology

Zhao Y,Li Z,Su L,Ballesteros-Tato A,Katz J,Michalek SM,Feng X,Zhang P

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

MOSPD2 is a therapeutic target for the treatment of CNS inflammation.

Clinical and experimental immunology

Yacov N,Kafri P,Salem Y,Propheta-Meiran O,Feldman B,Breitbart E,Mendel I

12-0112 was used in Flow cytometry/Cell sorting to study the therapeutic potential of MOSPD2 in central nervous system disease.

Sat Aug 01 00:00:00 EDT 2020

HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.

Journal of Cancer

Kim YD,Park SM,Ha HC,Lee AR,Won H,Cha H,Cho S,Cho JM

12-0112 was used in Flow cytometry/Cell sorting to study the HDAC inhibitor CG-745 and its function to enable the synergistic effects of the immune checkpoint inhibitor combination therapy in various cancers by suppressing tumor microenvironment.

Mon Sep 28 00:00:00 EDT 2020

Mouse bone marrow mesenchymal stem cells with distinct p53 statuses display differential characteristics.

Molecular medicine reports

Wang B,Wang L,Mao J,Wen H,Xu L,Ren Y,Du H,Yang H

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri May 01 00:00:00 EDT 2020

Mouse bone marrow mesenchymal stem cells with distinct p53 statuses display differential characteristics.

Molecular medicine reports

Wang B,Wang L,Mao J,Wen H,Xu L,Ren Y,Du H,Yang H

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri May 01 00:00:00 EDT 2020

Effects of Hypertonic Saline and Hydroxyethyl Starch on Myeloid-Derived Suppressor Cells in Hemorrhagic Shock Mice under Secondary Bacterial Attack.

BioMed research international

Jiang JK,Hong LJ,Lu YQ

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Dec 16 00:00:00 EST 2020

Irradiation induces cancer lung metastasis through activation of the cGAS-STING-CCL5 pathway in mesenchymal stromal cells.

Cell death & disease

Zheng Z,Jia S,Shao C,Shi Y

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu May 07 00:00:00 EDT 2020

Therapeutic Role of Inducible Nitric Oxide Synthase Expressing Myeloid-Derived Suppressor Cells in Acetaminophen-Induced Murine Liver Failure.

Frontiers in immunology

Hsu CY,Lin YC,Chang LY,Huang SK,Huang CH,Yang CK,Huang CT,Lin CY

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Jun 15 00:00:00 EDT 2021

Long Non-Coding RNA Hotairm1 Promotes S100A9 Support of MDSC Expansion during Sepsis.

Journal of clinical & cellular immunology

Alkhateeb T,Bah I,Kumbhare A,Youssef D,Yao ZQ,McCall CE,Gazzar ME

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Sat Aug 13 00:00:00 EDT 2022

The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.

Nature communications

Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Sep 17 00:00:00 EDT 2020

Exploring the Role of Osteosarcoma-Derived Extracellular Vesicles in Pre-Metastatic Niche Formation and Metastasis in the 143-B Xenograft Mouse Osteosarcoma Model.

Cancers

Mazumdar A,Urdinez J,Boro A,Arlt MJE,Egli FE,Niederöst B,Jaeger PK,Moschini G,Muff R,Fuchs B,Snedeker JG,Gvozdenovic A

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Nov 20 00:00:00 EST 2020

Lipin-1 Contributes to IL-4 Mediated Macrophage Polarization.

Frontiers in immunology

Chandran S,Schilke RM,Blackburn CMR,Yurochko A,Mirza R,Scott RS,Finck BN,Woolard MD

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Mar 29 00:00:00 EDT 2021

Ly6c^Lo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation.

Scientific reports

Alkhani A,Levy CS,Tsui M,Rosenberg KA,Polovina K,Mattis AN,Mack M,Van Dyken S,Wang BM,Maher JJ,Nijagal A

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Apr 28 00:00:00 EDT 2020

Stromal CCL2 Signaling Promotes Mammary Tumor Fibrosis through Recruitment of Myeloid-Lineage Cells.

Cancers

Kuziel G,Thompson V,D'Amato JV,Arendt LM

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Jul 28 00:00:00 EDT 2020

The immune response after noise damage in the cochlea is characterized by a heterogeneous mix of adaptive and innate immune cells.

Scientific reports

Rai V,Wood MB,Feng H,Schabla NM,Tu S,Zuo J

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Sep 16 00:00:00 EDT 2020

Macrophage-Associated Lipin-1 Promotes β-Oxidation in Response to Proresolving Stimuli.

ImmunoHorizons

Schilke RM,Blackburn CMR,Rao S,Krzywanski DM,Finck BN,Woolard MD

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Oct 19 00:00:00 EDT 2020

TNFAIP3 Plays a Role in Aging of the Hematopoietic System.

Frontiers in immunology

Smith MA,Culver-Cochran AE,Adelman ER,Rhyasen GW,Ma A,Figueroa ME,Starczynowski DT

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Apr 28 00:00:00 EDT 2021

Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement.

eLife

Kalinski AL,Yoon C,Huffman LD,Duncker PC,Kohen R,Passino R,Hafner H,Johnson C,Kawaguchi R,Carbajal KS,Jara JS,Hollis E,Geschwind DH,Segal BM,Giger RJ

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Dec 02 00:00:00 EST 2020

CD103⁺ cDC1 and endogenous CD8⁺ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function.

Nature communications

Kuhn NF,Lopez AV,Li X,Cai W,Daniyan AF,Brentjens RJ

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Dec 02 00:00:00 EST 2020

Authentication of Primary Murine Cell Lines by a Microfluidics-Based Lab-On-Chip System.

Biomedicines

Hong Y,Singh N,Bamopoulos S,Gjerga E,Schmalbrock LK,Balabanian K,Schick M,Keller U,Wirth M

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Dec 09 00:00:00 EST 2020

The armed oncolytic adenovirus ZD55-IL-24 eradicates melanoma by turning the tumor cells from the self-state into the nonself-state besides direct killing.

Cell death & disease

Hu HJ,Liang X,Li HL,Du CM,Hao JL,Wang HY,Gu JF,Ni AM,Sun LY,Xiao J,Hu JQ,Yuan H,Dai YS,Jin XT,Zhang KJ,Liu XY

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Nov 30 00:00:00 EST 2020

L-Selectin/CD62L is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men.

Cells

Drescher HK,Schippers A,Rosenhain S,Gremse F,Bongiovanni L,Bruin A,Eswaran S,Gallage SU,Pfister D,Szydlowska M,Heikenwalder M,Weiskirchen S,Wagner N,Trautwein C,Weiskirchen R,Kroy DC

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Apr 29 00:00:00 EDT 2020

L-Selectin/CD62L is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men.

Cells

Drescher HK,Schippers A,Rosenhain S,Gremse F,Bongiovanni L,Bruin A,Eswaran S,Gallage SU,Pfister D,Szydlowska M,Heikenwalder M,Weiskirchen S,Wagner N,Trautwein C,Weiskirchen R,Kroy DC

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Apr 29 00:00:00 EDT 2020

Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.

JCI insight

Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Aug 20 00:00:00 EDT 2020

Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.

JCI insight

Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Aug 20 00:00:00 EDT 2020

Protein Tyrosine Phosphatase Non-Receptor Type 2 Function in Dendritic Cells Is Crucial to Maintain Tissue Tolerance.

Frontiers in immunology

Hering L,Katkeviciute E,Schwarzfischer M,Busenhart P,Gottier C,Mrdjen D,Komuczki J,Wawrzyniak M,Lang S,Atrott K,Becher B,Rogler G,Scharl M,Spalinger MR

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Apr 12 00:00:00 EDT 2021

Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation.

Nature communications

Iske J,Seyda M,Heinbokel T,Maenosono R,Minami K,Nian Y,Quante M,Falk CS,Azuma H,Martin F,Passos JF,Niemann CU,Tchkonia T,Kirkland JL,Elkhal A,Tullius SG

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Aug 27 00:00:00 EDT 2020

Hyaluronan control of the primary vascular barrier during early mouse pregnancy is mediated by uterine NK cells.

JCI insight

Hadas R,Gershon E,Cohen A,Atrakchi O,Lazar S,Golani O,Dassa B,Elbaz M,Cohen G,Eilam R,Dekel N,Neeman M

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Nov 19 00:00:00 EST 2020

Hyaluronan control of the primary vascular barrier during early mouse pregnancy is mediated by uterine NK cells.

JCI insight

Hadas R,Gershon E,Cohen A,Atrakchi O,Lazar S,Golani O,Dassa B,Elbaz M,Cohen G,Eilam R,Dekel N,Neeman M

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Nov 19 00:00:00 EST 2020

Loss of Atg7 causes chaotic nucleosome assembly of mouse bone marrow CD11b⁺Ly6G^- myeloid cells.

Aging

Fang Y,Gu Y,Li L,Zhu L,Qian J,Zhao C,Xu L,Wei W,Du Y,Yuan N,Zhang S,Yuan Y,Xu Y,Jiang C,Wang J

12-0112 was used in Flow cytometry/Cell sorting to suggest that Atg7 is essential for maintaining proper nucleosome assembly and limiting aging in the bone marrow CD11b+Ly6G- population.

Tue Nov 24 00:00:00 EST 2020

Loss of Atg7 causes chaotic nucleosome assembly of mouse bone marrow CD11b⁺Ly6G^- myeloid cells.

Aging

Fang Y,Gu Y,Li L,Zhu L,Qian J,Zhao C,Xu L,Wei W,Du Y,Yuan N,Zhang S,Yuan Y,Xu Y,Jiang C,Wang J

12-0112 was used in Flow cytometry/Cell sorting to suggest that Atg7 is essential for maintaining proper nucleosome assembly and limiting aging in the bone marrow CD11b+Ly6G- population.

Tue Nov 24 00:00:00 EST 2020

Bivalent Inhibitor with Selectivity for Trimeric MMP-9 Amplifies Neutrophil Chemotaxis and Enables Functional Studies on MMP-9 Proteoforms.

Cells

Nuti E,Rossello A,Cuffaro D,Camodeca C,Van Bael J,van der Maat D,Martens E,Fiten P,Pereira RVS,Ugarte-Berzal E,Gouwy M,Opdenakker G,Vandooren J

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Jul 07 00:00:00 EDT 2020

Apoptotic bodies derived from mesenchymal stem cells promote cutaneous wound healing via regulating the functions of macrophages.

Stem cell research & therapy

Liu J,Qiu X,Lv Y,Zheng C,Dong Y,Dou G,Zhu B,Liu A,Wang W,Zhou J,Liu S,Liu S,Gao B,Jin Y

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Nov 27 00:00:00 EST 2020

Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations.

Nature communications

Xu ZX,Kim GH,Tan JW,Riso AE,Sun Y,Xu EY,Liao GY,Xu H,Lee SH,Do NY,Lee CH,Clipperton-Allen AE,Kwon S,Page DT,Lee KJ,Xu B

12-0112 was used in Immunocytochemistry to propose that functional perturbation of male microglia is an important cause for sex-biased autism spectrum disorders (ASD).

Tue Apr 14 00:00:00 EDT 2020

Activation of CpG-Rich Promoters Mediated by MLL Drives MOZ-Rearranged Leukemia.

Cell reports

Miyamoto R,Okuda H,Kanai A,Takahashi S,Kawamura T,Matsui H,Kitamura T,Kitabayashi I,Inaba T,Yokoyama A

12-0112-82 was used in Flow Cytometry to reveal that activation of unmethylated CpG-rich promoters mediated by MLL is the central mechanism of oncogenic self-renewal in MOZ-rearranged leukemia.

Tue Sep 29 00:00:00 EDT 2020

GDF3 Protects Mice against Sepsis-Induced Cardiac Dysfunction and Mortality by Suppression of Macrophage Pro-Inflammatory Phenotype.

Cells

Wang L,Li Y,Wang X,Wang P,Essandoh K,Cui S,Huang W,Mu X,Liu Z,Wang Y,Peng T,Fan GC

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Jan 03 00:00:00 EST 2020

Differential Activation of Macrophages Based on Their Environment in Advanced Age.

Chonnam medical journal

Lee DY,Lim JS,Cho KA

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

Efficient Strategies for Microglia Replacement in the Central Nervous System.

Cell reports

Xu Z,Rao Y,Huang Y,Zhou T,Feng R,Xiong S,Yuan TF,Qin S,Lu Y,Zhou X,Li X,Qin B,Mao Y,Peng B

12-0112 was used in Flow cytometry/Cell sorting to develop three efficient strategies for microglia replacement: microglia replacement by bone marrow transplantation (mrBMT), microglia replacement by peripheral blood (mrPB), and microglia replacement by microglia transplantation (mrMT).

Tue Aug 11 00:00:00 EDT 2020

Distinct Transcriptional Responses across Tissue-Resident Macrophages to Short-Term and Long-Term Metabolic Challenge.

Cell reports

Brykczynska U,Geigges M,Wiedemann SJ,Dror E,Böni-Schnetzler M,Hess C,Donath MY,Paro R

12-0112 was used in Flow cytometry/Cell sorting to provide a resource for assessing the impact of nutrition and over-nutrition on the spectrum of macrophages across tissues with a potential for identification of systemic responses.

Tue Feb 04 00:00:00 EST 2020

CRID3, a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment.

Journal of neuroinflammation

Chen YQ,Wang SN,Shi YJ,Chen J,Ding SQ,Tang J,Shen L,Wang R,Ding H,Hu JG,Lü HZ

12-0112 was used in Flow cytometry/Cell sorting to study the effect of CRID3 on the local microenvironment and the possible role in neuroprotection following spinal cord injury.

Sat Aug 29 00:00:00 EDT 2020

4-Hydroxyisoleucine relieves inflammation through iRhom2-dependent pathway in co-cultured macrophages and adipocytes with LPS stimulation.

BMC complementary medicine and therapies

Zhou C,Chen R,Gao F,Zhang J,Lu F

12-0112 was used in Flow cytometry/Cell sorting to investigate the effects and mechanisms of 4-HIL on obesity-induced inflammation in RAW264.7 macrophages and 3 T3-L1 adipocytes co-culture system.

Wed Dec 09 00:00:00 EST 2020

Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses.

Cell reports

Nadafi R,Gago de Graça C,Keuning ED,Koning JJ,de Kivit S,Konijn T,Henri S,Borst J,Reijmers RM,van Baarsen LGM,Mebius RE

12-0112-82 was used in Flow Cytometry to uncover the ability of LNSCs to suppress the early activation of autoreactive immune cells and maintain peripheral tolerance.

Tue Mar 24 00:00:00 EDT 2020

Chromatin accessibility promotes hematopoietic and leukemia stem cell activity.

Nature communications

Cabal-Hierro L,van Galen P,Prado MA,Higby KJ,Togami K,Mowery CT,Paulo JA,Xie Y,Cejas P,Furusawa T,Bustin M,Long HW,Sykes DB,Gygi SP,Finley D,Bernstein BE,Lane AA

12-0112-82 was used in Western Blot to report that the chromatin accessibility regulator HMGN1, a target of recurrent DNA copy gains in leukemia, controls myeloid differentiation.

Mon Mar 16 00:00:00 EDT 2020

Chromatin accessibility promotes hematopoietic and leukemia stem cell activity.

Nature communications

Cabal-Hierro L,van Galen P,Prado MA,Higby KJ,Togami K,Mowery CT,Paulo JA,Xie Y,Cejas P,Furusawa T,Bustin M,Long HW,Sykes DB,Gygi SP,Finley D,Bernstein BE,Lane AA

12-0112-82 was used in Western Blot to report that the chromatin accessibility regulator HMGN1, a target of recurrent DNA copy gains in leukemia, controls myeloid differentiation.

Mon Mar 16 00:00:00 EDT 2020

Macrophage secretion of miR-106b-5p causes renin-dependent hypertension.

Nature communications

Oh J,Matkovich SJ,Riek AE,Bindom SM,Shao JS,Head RD,Barve RA,Sands MS,Carmeliet G,Osei-Owusu P,Knutsen RH,Zhang H,Blumer KJ,Nichols CG,Mecham RP,Baldán Á,Benitez BA,Sequeira-Lopez ML,Gomez RA,Bernal-Mizrachi C

12-0112 was used in Flow cytometry/Cell sorting to confirm that macrophage miR-106b-5p secretion from impaired vitamin D receptor signalling causes inflammation-induced hypertension.

Wed Sep 23 00:00:00 EDT 2020

Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal.

Cell reports

Hidalgo San Jose L,Sunshine MJ,Dillingham CH,Chua BA,Kruta M,Hong Y,Hatters DM,Signer RAJ

12-0112 was used in Flow cytometry/Cell sorting to show that hematopoietic stem cells (HSCs) are dependent on low protein synthesis to maintain proteostasis, which promotes their self-renewal.

Tue Jan 07 00:00:00 EST 2020

Loss of FGFR3 Delays Acute Myeloid Leukemogenesis by Programming Weakly Pathogenic CD117-Positive Leukemia Stem-Like Cells.

Frontiers in pharmacology

Guo C,Ran Q,Sun C,Zhou T,Yang X,Zhang J,Pang S,Xiao Y

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Feb 16 00:00:00 EST 2021

Loss of FGFR3 Delays Acute Myeloid Leukemogenesis by Programming Weakly Pathogenic CD117-Positive Leukemia Stem-Like Cells.

Frontiers in pharmacology

Guo C,Ran Q,Sun C,Zhou T,Yang X,Zhang J,Pang S,Xiao Y

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Feb 16 00:00:00 EST 2021

PPARα Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction.

Cell reports

Yin X,Zeng W,Wu B,Wang L,Wang Z,Tian H,Wang L,Jiang Y,Clay R,Wei X,Qin Y,Zhang F,Zhang C,Jin L,Liang W

12-0112 was used in Flow cytometry/Cell sorting to report that fatty acid-carrying tumor-derived exosomes (TDEs) induce immune dysfunctional DCs to promote immune evasion.

Tue Oct 20 00:00:00 EDT 2020

Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis.

Nature

Yoshimi A,Lin KT,Wiseman DH,Rahman MA,Pastore A,Wang B,Lee SC,Micol JB,Zhang XJ,de Botton S,Penard-Lacronique V,Stein EM,Cho H,Miles RE,Inoue D,Albrecht TR,Somervaille TCP,Batta K,Amaral F,Simeoni F,Wilks DP,Cargo C,Intlekofer AM,Levine RL,Dvinge H,Bradley RK,Wagner EJ,Krainer AR,Abdel-Wahab O

12-0112 was used in Flow cytometry/Cell sorting to study the mutations in IDH2 and SRSF2 that together promote leukaemogenesis through coordinated effects on the epigenome and RNA splicing.

Tue Oct 01 00:00:00 EDT 2019

Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.

Nature

Wilkinson AC,Ishida R,Kikuchi M,Sudo K,Morita M,Crisostomo RV,Yamamoto R,Loh KM,Nakamura Y,Watanabe M,Nakauchi H,Yamazaki S

12-0112 was used in Flow cytometry/Cell sorting to identify polyvinyl alcohol as a functionally superior replacement for serum albumin that is compatible with good manufacturing practice.

Mon Jul 01 00:00:00 EDT 2019

Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer.

Immunity

Dmitrieva-Posocco O,Dzutsev A,Posocco DF,Hou V,Yuan W,Thovarai V,Mufazalov IA,Gunzer M,Shilovskiy IP,Khaitov MR,Trinchieri G,Waisman A,Grivennikov SI

12-0112-82 was used in Flow Cytometry to examine the impact of IL-1 signaling, a key regulator of the IL-17 pathway, in different cell types within the CRC microenvironment.

Tue Jan 15 00:00:00 EST 2019

Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice.

Nature immunology

Piliponsky AM,Shubin NJ,Lahiri AK,Truong P,Clauson M,Niino K,Tsuha AL,Nedospasov SA,Karasuyama H,Reber LL,Tsai M,Mukai K,Galli SJ

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Feb 01 00:00:00 EST 2019

Central nervous system regeneration is driven by microglia necroptosis and repopulation.

Nature neuroscience

Lloyd AF,Davies CL,Holloway RK,Labrak Y,Ireland G,Carradori D,Dillenburg A,Borger E,Soong D,Richardson JC,Kuhlmann T,Williams A,Pollard JW,des Rieux A,Priller J,Miron VE

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Jul 01 00:00:00 EDT 2019

Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells.

Nature cell biology

Nakahara F,Borger DK,Wei Q,Pinho S,Maryanovich M,Zahalka AH,Suzuki M,Cruz CD,Wang Z,Xu C,Boulais PE,Ma'ayan A,Greally JM,Frenette PS

12-0112 was used in Flow cytometry/Cell sorting to provide insight into the transcriptional regulation of the niche with implications for stem cell-based therapies.

Wed May 01 00:00:00 EDT 2019

Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.

Cell stem cell

Ni F,Yu WM,Wang X,Fay ME,Young KM,Qiu Y,Lam WA,Sulchek TA,Cheng T,Scadden DT,Qu CK

12-0112 was used in Flow cytometry/Cell sorting to show that Ptpn21 maintains cellular mechanics, which is correlated with its important functions in HSC niche retention and preservation of hematopoietic regeneration capacity.

Thu Apr 04 00:00:00 EDT 2019

A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis.

The Journal of clinical investigation

Han YH,Shin KO,Kim JY,Khadka DB,Kim HJ,Lee YM,Cho WJ,Cha JY,Lee BJ,Lee MO

12-0112 was used in Flow cytometry/Cell sorting to study the hepatic microenvironments that support the function of RORa as a polarity regulator.

Mon Mar 11 00:00:00 EDT 2019

Engulfment of mast cell secretory granules on skin inflammation boosts dendritic cell migration and priming efficiency.

The Journal of allergy and clinical immunology

Dudeck J,Froebel J,Kotrba J,Lehmann CHK,Dudziak D,Speier S,Nedospasov SA,Schraven B,Dudeck A

12-0112 was used in Flow cytometry/Cell sorting to show peripheral mast cells can modify dendritic cell functionality to influence lymphoid tissue-borne adaptive immunity.

Wed May 01 00:00:00 EDT 2019

Mir223 restrains autophagy and promotes CNS inflammation by targeting ATG16L1.

Autophagy

Li Y,Zhou D,Ren Y,Zhang Z,Guo X,Ma M,Xue Z,Lv J,Liu H,Xi Q,Jia L,Zhang L,Liu Y,Zhang Q,Yan J,Da Y,Gao F,Yue J,Yao Z,Zhang R

12-0112-82 was used in Flow Cytometry to find that Mir223 deficiency significantly ameliorated CNS inflammation, demyelination and the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) and increased resting microglia and autophagy in brain microglial cells.

Fri Mar 01 00:00:00 EST 2019

Single-Cell Analysis Reveals Regulatory Gene Expression Dynamics Leading to Lineage Commitment in Early T Cell Development.

Cell systems

Zhou W,Yui MA,Williams BA,Yun J,Wold BJ,Cai L,Rothenberg EV

12-0112 was used in Flow cytometry/Cell sorting to imply that multilineage priming is integral to T cell specification.

Wed Oct 23 00:00:00 EDT 2019

Seselin ameliorates inflammation via targeting Jak2 to suppress the proinflammatory phenotype of macrophages.

British journal of pharmacology

Feng L,Sun Y,Song P,Xu L,Wu X,Wu X,Shen Y,Sun Y,Kong L,Wu X,Xu Q

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2019

Distinct Tie2 tyrosine phosphorylation sites dictate phenotypic switching in endothelial progenitor cells.

Journal of cellular physiology

Siavashi V,Nassiri SM,Rahbarghazi R,Mohseni Z,Sharifi AM

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed May 01 00:00:00 EDT 2019

CCL9/CCR1 induces myeloid‑derived suppressor cell recruitment to the spleen in a murine H22 orthotopic hepatoma model.

Oncology reports

Li B,Zhang S,Huang N,Chen H,Wang P,Yang J,Li Z

12-0112-82 was used in Flow Cytometry to indicate that CCL9 secreted by splenic macrophages induces a C-C motif chemokine receptor 1-dependent accumulation of myeloid-derived suppressor cells in the spleen in a murine H22 hepatoma model.

Tue Jan 01 00:00:00 EST 2019

The Contribution of the Omentum to the Outcome From Sepsis: An Experimental Animal Study.

Shock (Augusta, Ga.)

Wang AW,Cauvi DM,Hawisher D,Reyes T,Coimbra R,Bickler S,De Maio A

12-0112-82 was used in Flow Cytometry to understand the link between the omentum and possible sepsis.

Sun Dec 01 00:00:00 EST 2019

Antiallodynic Effects of Cannabinoid Receptor 2 (CB₂R) Agonists on Retrovirus Infection-Induced Neuropathic Pain.

Pain research & management

Sheng WS,Chauhan P,Hu S,Prasad S,Lokensgard JR

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Dec 16 00:00:00 EST 2019

Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.

Anti-cancer drugs

Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice.

Cell reports

Zeng J,Wang Y,Luo Z,Chang LC,Yoo JS,Yan H,Choi Y,Xie X,Deverman BE,Gradinaru V,Gupton SL,Zlokovic BV,Zhao Z,Jung JU

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Apr 09 00:00:00 EDT 2019

Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis.

Nature communications

Zhang X,Zhang H,Xu C,Li X,Li M,Wu X,Pu W,Zhou B,Wang H,Li D,Ding Q,Ying H,Wang H,Zhang H

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Sep 13 00:00:00 EDT 2019

Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia.

Cell stem cell

McKenzie MD,Ghisi M,Oxley EP,Ngo S,Cimmino L,Esnault C,Liu R,Salmon JM,Bell CC,Ahmed N,Erlichster M,Witkowski MT,Liu GJ,Chopin M,Dakic A,Simankowicz E,Pomilio G,Vu T,Krsmanovic P,Su S,Tian L,Baldwin TM,Zalcenstein DA,DiRago L,Wang S,Metcalf D,Johnstone RW,Croker BA,Lancaster GI,Murphy AJ,Naik SH,Nutt SL,Pospisil V,Schroeder T,Wall M,Dawson MA,Wei AH,de Thé H,Ritchie ME,Zuber J,Dickins RA

12-0112 was used in Flow cytometry/Cell sorting to investigate cancer stem cell plasticity in acute myeloid leukemia.

Thu Aug 01 00:00:00 EDT 2019

Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice.

Cell reports

Matsumura T,Ikebe T,Arikawa K,Hosokawa M,Aiko M,Iguchi A,Togashi I,Kai S,Ohara S,Ohara N,Ohnishi M,Watanabe H,Kobayashi K,Takeyama H,Yamasaki S,Takahashi Y,Ato M

12-0112-82 was used in Flow Cytometry to show IFN-γ-producing immature myeloid cells can provide protection to mice in invasive group A Streptococcus infection.

Tue Apr 09 00:00:00 EDT 2019

Neural anti-inflammatory action mediated by two types of acetylcholine receptors in the small intestine.

Scientific reports

Kimura H,Imura YK,Tomiyasu H,Mihara T,Kaji N,Ohno K,Unno T,Tanahashi Y,Jan TR,Tsubone H,Ozaki H,Hori M

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Apr 10 00:00:00 EDT 2019

MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment.

Journal for immunotherapy of cancer

Fang DD,Tang Q,Kong Y,Wang Q,Gu J,Fang X,Zou P,Rong T,Wang J,Yang D,Zhai Y

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Nov 28 00:00:00 EST 2019

Muscularis Propria Macrophages Alter the Proportion of Nitrergic but Not Cholinergic Gastric Myenteric Neurons.

Cellular and molecular gastroenterology and hepatology

Cipriani G,Terhaar ML,Eisenman ST,Ji S,Linden DR,Wright AM,Sha L,Ordog T,Szurszewski JH,Gibbons SJ,Farrugia G

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Jun 04 00:00:00 EDT 2019

Chronic alcohol consumption exacerbates murine cytomegalovirus infection via impairing nonspecific and specific NK activation in mice.

FASEB bioAdvances

Little A,Li Y,Zhang F,Zhang H

12-0112-82 was used in Flow Cytometry to demonstrate that chronic alcohol consumption exacerbates cytomegalovirus infection via impairing nonspecific and specific NK cell activation, specifically IFN-γ and perforin production.

Tue Jan 01 00:00:00 EST 2019

Single cell transcriptomics based-MacSpectrum reveals novel macrophage activation signatures in diseases.

JCI insight

Li C,Menoret A,Farragher C,Ouyang Z,Bonin C,Holvoet P,Vella AT,Zhou B

12-0112-82 was used in Flow Cytometry to develop a single-cell transcriptome annotation system that can capture adipose tissue macrophages multifaceted activation profiles.

Tue Apr 16 00:00:00 EDT 2019

Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques.

Arteriosclerosis, thrombosis, and vascular biology

Fotakis P,Kothari V,Thomas DG,Westerterp M,Molusky MM,Altin E,Abramowicz S,Wang N,He Y,Heinecke JW,Bornfeldt KE,Tall AR

12-0112-82 was used in Flow Cytometry to show that reconstituted HDL infusions in hypercholesterolemic atherosclerotic mice produced anti-inflammatory effects in lesion macrophages suggesting a beneficial therapeutic effect of HDL in vivo.

Sun Dec 01 00:00:00 EST 2019

Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.

Frontiers in immunology

Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Oct 14 00:00:00 EDT 2020

Exposure to Cigarette Smoke Augments Post-ischemic Brain Injury and Inflammation via Mobilization of Neutrophils and Monocytes.

Frontiers in immunology

Li H,Li X,Gao S,Wang D,Gao X,Li Y,Wang X,Cui Z,Ma H,Liu Q,Li M

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Distinct Roles of α7 nAChRs in Antigen-Presenting Cells and CD4⁺ T Cells in the Regulation of T Cell Differentiation.

Frontiers in immunology

Mashimo M,Komori M,Matsui YY,Murase MX,Fujii T,Takeshima S,Okuyama H,Ono S,Moriwaki Y,Misawa H,Kawashima K

12-0112 was used in Flow cytometry/Cell sorting to investigate the specific function α7 nAChRs on T cells and antigen presenting cells (APCs) in mice.

Fri Aug 21 00:00:00 EDT 2020

Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity.

Nature metabolism

Seo JB,Riopel M,Cabrales P,Huh JY,Bandyopadhyay GK,Andreyev AY,Murphy AN,Beeman SC,Smith GI,Klein S,Lee YS,Olefsky JM

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2019

Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses.

Nature communications

Kurelac I,Iommarini L,Vatrinet R,Amato LB,De Luise M,Leone G,Girolimetti G,Umesh Ganesh N,Bridgeman VL,Ombrato L,Columbaro M,Ragazzi M,Gibellini L,Sollazzo M,Feichtinger RG,Vidali S,Baldassarre M,Foriel S,Vidone M,Cossarizza A,Grifoni D,Kofler B,Malanchi I,Porcelli AM,Gasparre G

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Feb 22 00:00:00 EST 2019

The IRE1α Arm of UPR Regulates Muscle Cells Immune Characters by Restraining p38 MAPK Activation.

Frontiers in physiology

Gu R,Huang T,Xiao J,Liao Z,Li J,Lan H,Ouyang J,Hu J,Liao H

12-0112-82 was used in Flow Cytometry to demonstrate that p38 MAPK contributes greatly to IRE1α arm-dependent immunobiological suppression in myocytes under inflammatory stress conditions.

Wed Sep 30 00:00:00 EDT 2020

Sphingomyelin Synthase 2 Inhibition Ameliorates Cerebral Ischemic Reperfusion Injury Through Reducing the Recruitment of Toll-Like Receptor 4 to Lipid Rafts.

Journal of the American Heart Association

Xue J,Yu Y,Zhang X,Zhang C,Zhao Y,Liu B,Zhang L,Wang L,Chen R,Gao X,Jiao P,Song G,Jiang XC,Qin S

12-0112 was used in Flow cytometry/Cell sorting to investigate the role of SMS2 in a mouse model of cerebral I/R.

Tue Nov 19 00:00:00 EST 2019

Myeloid Folliculin balances mTOR activation to maintain innate immunity homeostasis.

JCI insight

Li J,Wada S,Weaver LK,Biswas C,Behrens EM,Arany Z

12-0112 was used in Flow cytometry/Cell sorting to investigate the effects of LPS on the tumour suppressor folliculin.

Thu Mar 07 00:00:00 EST 2019

Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits.

Nature communications

Wu Y,Du S,Johnson JL,Tung HY,Landers CT,Liu Y,Seman BG,Wheeler RT,Costa-Mattioli M,Kheradmand F,Zheng H,Corry DB

12-0112 was used in Flow cytometry/Cell sorting to show that intravenous injection of 25,000 C. albicans cells causes a highly localised cerebritis marked by the accumulation of activated microglial and astroglial cells around yeast aggregates, forming fungal-induced glial granulomas.

Fri Jan 04 00:00:00 EST 2019

Club cells form lung adenocarcinomas and maintain the alveoli of adult mice.

eLife

Spella M,Lilis I,Pepe MA,Chen Y,Armaka M,Lamort AS,Zazara DE,Roumelioti F,Vreka M,Kanellakis NI,Wagner DE,Giannou AD,Armenis V,Arendt KA,Klotz LV,Toumpanakis D,Karavana V,Zakynthinos SG,Giopanou I,Marazioti A,Aidinis V,Sotillo R,Stathopoulos GT

12-0112-82 was used in Flow Cytometry to study the cellular origins of environmental-induced lung tumors and of the dysfunctional airway and alveolar epithelial turnover observed with chronic lung diseases by combining mouse models of genetic labeling and ablation of airway (club) and alveolar cells with exposure to environmental noxious and carcinogenic agents.

Wed May 29 00:00:00 EDT 2019

NIRF-Molecular Imaging with Synovial Macrophages-Targeting Vsig4 Nanobody for Disease Monitoring in a Mouse Model of Arthritis.

International journal of molecular sciences

Zheng F,Luo S,Ouyang Z,Zhou J,Mo H,Schoonooghe S,Muyldermans S,De Baetselier P,Raes G,Wen Y

12-0112-82 was used in Flow Cytometry to assess the specificity and potential for arthritis monitoring using near-infrared fluorescence Cy7-labeled Vsig4 nanobody.

Mon Jul 08 00:00:00 EDT 2019

Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR.

Nature communications

Zhu H,Bhatt B,Sivaprakasam S,Cai Y,Liu S,Kodeboyina SK,Patel N,Savage NM,Sharma A,Kaufman RJ,Li H,Singh N

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Mar 06 00:00:00 EST 2019

The nuclear variant of bone morphogenetic protein 2 (nBMP2) is expressed in macrophages and alters calcium response.

Scientific reports

Tellez Freitas CM,Burrell HR,Valdoz JC,Hamblin GJ,Raymond CM,Cox TD,Johnson DK,Andersen JL,Weber KS,Bridgewater LC

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Jan 30 00:00:00 EST 2019

Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes.

Nature communications

Galle-Treger L,Sankaranarayanan I,Hurrell BP,Howard E,Lo R,Maazi H,Lewis G,Banie H,Epstein AL,Hu P,Rehan VK,Gilliland FD,Allayee H,Soroosh P,Sharpe AH,Akbari O

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Feb 12 00:00:00 EST 2019

NLRX1 Enhances Glutamate Uptake and Inhibits Glutamate Release by Astrocytes.

Cells

Mahmoud S,Gharagozloo M,Simard C,Amrani A,Gris D

12-0112-82 was used in Flow cytometry/Cell sorting to identify NLRX1 as a potential regulator of glutamate homeostasis in the CNS.

Tue Apr 30 00:00:00 EDT 2019

Effect of hyperthermia on improving neutrophil restoration after intraperitoneal chemotherapy.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group

Huang WC,Wu CC,Hsu YT,Chang CL

12-0112-82 was used in Flow Cytometry to compare the effects of hyperthermic intraperitoneal chemotherapy (HIPEC) and conventional IP chemotherapy on bone marrow suppression and evaluated whether HIPEC increased neutrophil recovery.

Fri Apr 10 00:00:00 EDT 2020

The Inhibitory T Cell Receptors PD1 and 2B4 Are Differentially Regulated on CD4 and CD8 T Cells in a Mouse Model of Non-alcoholic Steatohepatitis.

Frontiers in pharmacology

Hansel C,Erschfeld S,Baues M,Lammers T,Weiskirchen R,Trautwein C,Kroy DC,Drescher HK

12-0112 was used in Flow cytometry/Cell sorting to investigate the expression profile of inhibitory T cell receptors on CD4 and CD8 T cells in a mouse model of non-alcoholic steatohepatitis.

Wed Sep 30 00:00:00 EDT 2020

Toll-Like Receptor 7 Agonist-Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells.

Cellular and molecular gastroenterology and hepatology

Kiyohara H,Sujino T,Teratani T,Miyamoto K,Arai MM,Nomura E,Harada Y,Aoki R,Koda Y,Mikami Y,Mizuno S,Naganuma M,Hisamatsu T,Kanai T

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Apr 29 00:00:00 EDT 2019

Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy.

Nature communications

Shi L,Wang J,Ding N,Zhang Y,Zhu Y,Dong S,Wang X,Peng C,Zhou C,Zhou L,Li X,Shi H,Wu W,Long X,Wu C,Liao W

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Nov 28 00:00:00 EST 2019

SMAC Mimetic Debio 1143 and Ablative Radiation Therapy Synergize to Enhance Antitumor Immunity against Lung Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Tao Z,McCall NS,Wiedemann N,Vuagniaux G,Yuan Z,Lu B

12-0112-82 was used in Flow Cytometry to show that Debio 1143 augments the tumor-specific adaptive immunity induced by ART, while reversing host immunosuppressive cell infiltrates in the tumor microenvironment in a TNFα, IFNγ, and CD8+ T-cell-dependent manner.

Fri Feb 01 00:00:00 EST 2019

DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation.

Nature medicine

Xiao Q,Wu J,Wang WJ,Chen S,Zheng Y,Yu X,Meeth K,Sahraei M,Bothwell ALM,Chen L,Bosenberg M,Chen J,Sexl V,Sun L,Li L,Tang W,Wu D

12-0112 was used in Flow cytometry/Cell sorting to identify a novel tumour immune-suppressive mechanism and immunotherapeutic targets particularly relevant for colorectal cancers and a subset of melanomas.

Thu Mar 01 00:00:00 EST 2018

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release.

Nature

Morioka S,Perry JSA,Raymond MH,Medina CB,Zhu Y,Zhao L,Serbulea V,Onengut-Gumuscu S,Leitinger N,Kucenas S,Rathmell JC,Makowski L,Ravichandran KS

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Nov 01 00:00:00 EDT 2018

Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.

Nature

Meisel M,Hinterleitner R,Pacis A,Chen L,Earley ZM,Mayassi T,Pierre JF,Ernest JD,Galipeau HJ,Thuille N,Bouziat R,Buscarlet M,Ringus DL,Wang Y,Li Y,Dinh V,Kim SM,McDonald BD,Zurenski MA,Musch MW,Furtado GC,Lira SA,Baier G,Chang EB,Eren AM,Weber CR,Busque L,Godley LA,Verdú EF,Barreiro LB,Jabri B

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue May 01 00:00:00 EDT 2018

Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.

Cell

Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Jan 25 00:00:00 EST 2018

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

Cell

Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Jun 28 00:00:00 EDT 2018

Chanzyme TRPM7 Mediates the Ca²⁺ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation.

Immunity

Schappe MS,Szteyn K,Stremska ME,Mendu SK,Downs TK,Seegren PV,Mahoney MA,Dixit S,Krupa JK,Stipes EJ,Rogers JS,Adamson SE,Leitinger N,Desai BN

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Jan 16 00:00:00 EST 2018

E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.

Immunity

Li Q,Li D,Zhang X,Wan Q,Zhang W,Zheng M,Zou L,Elly C,Lee JH,Liu YC

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Feb 20 00:00:00 EST 2018

A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.

Immunity

Xia P,Wang S,Ye B,Du Y,Li C,Xiong Z,Qu Y,Fan Z

12-0112 was used in Flow cytometry/Cell sorting to study circular RNA-mediated maintenance of hematopoeitic stem cell homeostasis.

Tue Apr 17 00:00:00 EDT 2018

Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis.

Immunity

Hirota K,Hashimoto M,Ito Y,Matsuura M,Ito H,Tanaka M,Watanabe H,Kondoh G,Tanaka A,Yasuda K,Kopf M,Potocnik AJ,Stockinger B,Sakaguchi N,Sakaguchi S

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Jun 19 00:00:00 EDT 2018

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.

Cancer cell

Lee SC,North K,Kim E,Jang E,Obeng E,Lu SX,Liu B,Inoue D,Yoshimi A,Ki M,Yeo M,Zhang XJ,Kim MK,Cho H,Chung YR,Taylor J,Durham BH,Kim YJ,Pastore A,Monette S,Palacino J,Seiler M,Buonamici S,Smith PG,Ebert BL,Bradley RK,Abdel-Wahab O

12-0112 was used in Flow cytometry/Cell sorting to identify shared consequences of splicing-factor mutations and the basis for their mutual exclusivity.

Mon Aug 13 00:00:00 EDT 2018

CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature.

Nature neuroscience

Louveau A,Herz J,Alme MN,Salvador AF,Dong MQ,Viar KE,Herod SG,Knopp J,Setliff JC,Lupi AL,Da Mesquita S,Frost EL,Gaultier A,Harris TH,Cao R,Hu S,Lukens JR,Smirnov I,Overall CC,Oliver G,Kipnis J

12-0112 was used in Flow cytometry/Cell sorting to demonstrate that meningeal lymphatics fulfill two critical criteria: they assist in the drainage of cerebrospinal fluid components and enable immune cells to enter draining lymph nodes in a CCR7-dependent manner.

Mon Oct 01 00:00:00 EDT 2018

Insulin resistance causes inflammation in adipose tissue.

The Journal of clinical investigation

Shimobayashi M,Albert V,Woelnerhanssen B,Frei IC,Weissenberger D,Meyer-Gerspach AC,Clement N,Moes S,Colombi M,Meier JA,Swierczynska MM,Jenö P,Beglinger C,Peterli R,Hall MN

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Apr 02 00:00:00 EDT 2018

Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease.

The Journal of clinical investigation

Tsantikos E,Lau M,Castelino CM,Maxwell MJ,Passey SL,Hansen MJ,McGregor NE,Sims NA,Steinfort DP,Irving LB,Anderson GP,Hibbs ML

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Jun 01 00:00:00 EDT 2018

Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation.

The Journal of experimental medicine

Nagase R,Inoue D,Pastore A,Fujino T,Hou HA,Yamasaki N,Goyama S,Saika M,Kanai A,Sera Y,Horikawa S,Ota Y,Asada S,Hayashi Y,Kawabata KC,Takeda R,Tien HF,Honda H,Abdel-Wahab O,Kitamura T

12-0112 was used in Flow cytometry/Cell sorting to study the effects of physiological expression of a C-terminal truncated AsXenopus laevis1 mutant in vivo.

Mon Jun 04 00:00:00 EDT 2018

Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney.

Journal of the American Society of Nephrology : JASN

Micanovic R,Khan S,Janosevic D,Lee ME,Hato T,Srour EF,Winfree S,Ghosh J,Tong Y,Rice SE,Dagher PC,Wu XR,El-Achkar TM

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Mar 01 00:00:00 EST 2018

11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis.

Journal of autoimmunity

Hardy RS,Fenton C,Croft AP,Naylor AJ,Begum R,Desanti G,Buckley CD,Lavery G,Cooper MS,Raza K

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Aug 01 00:00:00 EDT 2018

MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis.

Proceedings of the National Academy of Sciences of the United States of America

Suarez-Lopez L,Sriram G,Kong YW,Morandell S,Merrick KA,Hernandez Y,Haigis KM,Yaffe MB

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue May 01 00:00:00 EDT 2018

Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition.

Proceedings of the National Academy of Sciences of the United States of America

Giurisato E,Xu Q,Lonardi S,Telfer B,Russo I,Pearson A,Finegan KG,Wang W,Wang J,Gray NS,Vermi W,Xia Z,Tournier C

12-0112 was used in Flow cytometry/Cell sorting to suggest that blocking ERK5 constitutes a treatment strategy to reprogram macrophages toward an antitumor state by inhibiting STAT3-induced gene expression.

Tue Mar 20 00:00:00 EDT 2018

STAT6 Mediates Footpad Immunopathology in the Absence of IL-12p40 Following Infection of Susceptible BALB/c Mice With Leishmania major.

Frontiers in immunology

Kauffmann F,Meert E,de Jonge K,Elkrim Y,Hanot Mambres D,Denis O,Muraille E,Magez S,De Trez C

12-0112 was used in Flow cytometry/Cell sorting to refine the role of IL-12p40 cytokine.

Fri May 10 00:00:00 EDT 2019

Lenalidomide and Programmed Death-1 Blockade Synergistically Enhances the Effects of Dendritic Cell Vaccination in a Model of Murine Myeloma.

Frontiers in immunology

Vo MC,Jung SH,Chu TH,Lee HJ,Lakshmi TJ,Park HS,Kim HJ,Rhee JH,Lee JJ

12-0112 was used in Flow cytometry/Cell sorting to investigate the efficacy of dendritic cell vaccination in combination with lenalidomide and PD-1 blockade in a model of murine myeloma.

Sun Jan 03 00:00:00 EST 2021

De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages.

Frontiers in immunology

Stüve P,Minarrieta L,Erdmann H,Arnold-Schrauf C,Swallow M,Guderian M,Krull F,Hölscher A,Ghorbani P,Behrends J,Abraham WR,Hölscher C,Sparwasser TD,Berod L

12-0112-82 was used in Flow Cytometry to reveal that acetyl-CoA carboxylase 1-dependent fatty acid synthesis is a crucial mechanism in T cells, but not dendritic cells or macrophages, to fight against mycobacterial infection.

Wed Apr 10 00:00:00 EDT 2019

Protective role of γδ T cells in cigarette smoke and influenza infection.

Mucosal immunology

Hong MJ,Gu BH,Madison MC,Landers C,Tung HY,Kim M,Yuan X,You R,Machado AA,Gilbert BE,Soroosh P,Elloso M,Song L,Chen M,Corry DB,Diehl G,Kheradmand F

12-0112 was used in Flow cytometry/Cell sorting to demonstrate that cigarette smoke induces IL-17A expression in the lungs and inhibits γδ T-cell-mediated protective anti-viral immune responses.

Tue May 01 00:00:00 EDT 2018

VISTA expression by microglia decreases during inflammation and is differentially regulated in CNS diseases.

Glia

Borggrewe M,Grit C,Den Dunnen WFA,Burm SM,Bajramovic JJ,Noelle RJ,Eggen BJL,Laman JD

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Sat Dec 01 00:00:00 EST 2018

Murine CMV induces type 1 IFN that impairs differentiation of MDSCs critical for transplantation tolerance.

Blood advances

Dangi A,Zhang L,Zhang X,Luo X

12-0112 was used in Flow cytometry/Cell sorting to provide a solid foundation for seeking effective therapies for promoting transplantation tolerance in settings of CMV infection.

Tue Mar 27 00:00:00 EDT 2018

Bone loss in C57BL/6J-OlaHsd mice, a substrain of C57BL/6J carrying mutated alpha-synuclein and multimerin-1 genes.

Journal of cellular physiology

Liron T,Raphael B,Hiram-Bab S,Bab IA,Gabet Y

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Jan 01 00:00:00 EST 2018

Inactivation of mTORC1 Signaling in Osterix-Expressing Cells Impairs B-cell Differentiation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Wang Y,Xiao M,Tao C,Chen J,Wang Z,Yang J,Chen Z,Zou Z,Liu A,Cai D,Jiang Y,Ding C,Li M,Bai X

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Sun Apr 01 00:00:00 EDT 2018

Frontline Science: Macrophage-derived exosomes promote neutrophil necroptosis following hemorrhagic shock.

Journal of leukocyte biology

Jiao Y,Li Z,Loughran PA,Fan EK,Scott MJ,Li Y,Billiar TR,Wilson MA,Shi X,Fan J

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

The Outcome of the Cryptococcus neoformans-Macrophage Interaction Depends on Phagolysosomal Membrane Integrity.

Journal of immunology (Baltimore, Md. : 1950)

De Leon-Rodriguez CM,Rossi DCP,Fu MS,Dragotakes Q,Coelho C,Guerrero Ros I,Caballero B,Nolan SJ,Casadevall A

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Sun Jul 15 00:00:00 EDT 2018

The Outcome of the Cryptococcus neoformans-Macrophage Interaction Depends on Phagolysosomal Membrane Integrity.

Journal of immunology (Baltimore, Md. : 1950)

De Leon-Rodriguez CM,Rossi DCP,Fu MS,Dragotakes Q,Coelho C,Guerrero Ros I,Caballero B,Nolan SJ,Casadevall A

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Sun Jul 15 00:00:00 EDT 2018

PD-L1 Prevents the Development of Autoimmune Heart Disease in Graft-versus-Host Disease.

Journal of immunology (Baltimore, Md. : 1950)

Juchem KW,Sacirbegovic F,Zhang C,Sharpe AH,Russell K,McNiff JM,Demetris AJ,Shlomchik MJ,Shlomchik WD

12-0112 was used in Flow cytometry/Cell sorting to study whether effector memory T cells induce less graft-versus-host disease due to increased sensitivity to PD-ligands.

Mon Jan 15 00:00:00 EST 2018

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

Journal of cell science

Tseng HY,Samarelli AV,Kammerer P,Scholze S,Ziegler T,Immler R,Zent R,Sperandio M,Sanders CR,Fässler R,Böttcher RT

12-0112 was used in Flow cytometry/Cell sorting to offer a global view on cytoplasmic proteins interacting with different integrins and provide evidence for the existence of conformation-specific integrin interactors.

Wed Nov 21 00:00:00 EST 2018

Primary cilia disruption differentially affects the infiltrating and resident macrophage compartment in the liver.

American journal of physiology. Gastrointestinal and liver physiology

Zimmerman KA,Song CJ,Gonzalez-Mize N,Li Z,Yoder BK

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Jun 01 00:00:00 EDT 2018

Anti‑IL‑39 (IL‑23p19/Ebi3) polyclonal antibodies ameliorate autoimmune symptoms in lupus‑like mice.

Molecular medicine reports

Wang X,Zhang Y,Wang Z,Liu X,Zhu G,Han G,Chen G,Hou C,Wang T,Shen B,Li Y,Xiao H,Ma N,Wang R

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Jan 01 00:00:00 EST 2018

A novel method to isolate mesenchymal stem cells from mouse umbilical cord.

Molecular medicine reports

Zhang B,Zhang J,Shi H,Mao F,Wang J,Yan Y,Zhang X,Qian H,Xu W

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Jan 01 00:00:00 EST 2018

Clonal expansion and myeloid leukemia progression modeled by multiplex gene editing of murine hematopoietic progenitor cells.

Experimental hematology

Shi X,Kitano A,Jiang Y,Luu V,Hoegenauer KA,Nakada D

12-0112 was used in Flow cytometry/Cell sorting to establish that the CRISPR/Cas9-mediated multiplex mutagenesis can be used to engineer a variety of murine models of hematological malignancies with complex genetic architectures seen in human disease.

Wed Aug 01 00:00:00 EDT 2018

Simultaneous isolation of mesenchymal stem cells and endothelial progenitor cells derived from murine bone marrow.

Experimental and therapeutic medicine

Wang X,Zhao Z,Zhang H,Hou J,Feng W,Zhang M,Guo J,Xia J,Ge Q,Chen X,Wu X

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Sat Dec 01 00:00:00 EST 2018

Systemic Candidiasis and TLR2 Agonist Exposure Impact the Antifungal Response of Hematopoietic Stem and Progenitor Cells.

Frontiers in cellular and infection microbiology

Martínez A,Bono C,Megías J,Yáñez A,Gozalbo D,Gil ML

12-0112 was used in Flow cytometry/Cell sorting to assign an active role for HSPCs in sensing pathogens during infection and in contributing to host protection by diverse mechanisms.

Fri Aug 30 00:00:00 EDT 2019

iRhom2-mediated proinflammatory signalling regulates heart repair following myocardial infarction.

JCI insight

Barnette DN,Cahill TJ,Gunadasa-Rohling M,Carr CA,Freeman M,Riley PR

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Feb 08 00:00:00 EST 2018

STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia.

Cell reports

Saint Fleur-Lominy S,Maus M,Vaeth M,Lange I,Zee I,Suh D,Liu C,Wu X,Tikhonova A,Aifantis I,Feske S

12-0112 was used in Flow cytometry/Cell sorting to investigate the role of store-operated Ca2+ entry mediated by ORAI1, and STIM1 and STIM2 in T-cell acute lymphoblastic leukaemia.

Tue Sep 11 00:00:00 EDT 2018

Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice.

Nature communications

Grinenko T,Eugster A,Thielecke L,Ramasz B,Krüger A,Dietz S,Glauche I,Gerbaulet A,von Bonin M,Basak O,Clevers H,Chavakis T,Wielockx B

12-0112 was used in Flow cytometry/Cell sorting to study the mechanisms that control fate decision in adult haematopoietic stem cells.s.

Tue May 15 00:00:00 EDT 2018

A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors.

Nature communications

Wang T,Wang D,Yu H,Feng B,Zhou F,Zhang H,Zhou L,Jiao S,Li Y

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Apr 18 00:00:00 EDT 2018

Diet-Induced Obesity Elicits Macrophage Infiltration and Reduction in Spine Density in the Hypothalami of Male but Not Female Mice.

Frontiers in immunology

Lainez NM,Jonak CR,Nair MG,Ethell IM,Wilson EH,Carson MJ,Coss D

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Sep 25 00:00:00 EDT 2019

Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease.

JCI insight

Moreno-Fernandez ME,Giles DA,Stankiewicz TE,Sheridan R,Karns R,Cappelletti M,Lampe K,Mukherjee R,Sina C,Sallese A,Bridges JP,Hogan SP,Aronow BJ,Hoebe K,Divanovic S

12-0112 was used in Flow cytometry/Cell sorting to demonstrate that β-oxidation links metabolism and immune responsiveness.

Thu Mar 22 00:00:00 EDT 2018

Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice.

Journal of neuroinflammation

Unger MS,Schernthaner P,Marschallinger J,Mrowetz H,Aigner L

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Sep 21 00:00:00 EDT 2018

Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice.

Journal of neuroinflammation

Unger MS,Schernthaner P,Marschallinger J,Mrowetz H,Aigner L

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Sep 21 00:00:00 EDT 2018

Nasal priming by a murine coronavirus provides protective immunity against lethal heterologous virus pneumonia.

JCI insight

Hua X,Vijay R,Channappanavar R,Athmer J,Meyerholz DK,Pagedar N,Tilley S,Perlman S

12-0112 was used in Flow cytometry/Cell sorting to study the mechanisms by which nasal inoculation of murine coronavirus in the absence of direct lung infection primes the lung immune environment.

Thu Jun 07 00:00:00 EDT 2018

Investigation of tumor-tumor interactions in a double human cervical carcinoma xenograft model in nude mice.

Oncotarget

Mertens B,Cristina de Araujo Nogueira T,Topalis D,Stranska R,Snoeck R,Andrei G

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Apr 24 00:00:00 EDT 2018

BNIP3 modulates the interface between B16-F10 melanoma cells and immune cells.

Oncotarget

Romano E,Rufo N,Korf H,Mathieu C,Garg AD,Agostinis P

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Apr 03 00:00:00 EDT 2018

An immune cell spray (ICS) formulation allows for the delivery of functional monocyte/macrophages.

Scientific reports

Beneke V,Küster F,Neehus AL,Hesse C,Lopez-Rodriguez E,Haake K,Rafiei Hashtchin A,Schott JW,Walter D,Braun A,Wolkers WF,Ackermann M,Lachmann N

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Nov 02 00:00:00 EDT 2018

Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes.

Nature communications

Pezoldt J,Pasztoi M,Zou M,Wiechers C,Beckstette M,Thierry GR,Vafadarnejad E,Floess S,Arampatzi P,Buettner M,Schweer J,Fleissner D,Vital M,Pieper DH,Basic M,Dersch P,Strowig T,Hornef M,Bleich A,Bode U,Pabst O,Bajénoff M,Saliba AE,Huehn J

12-0112 was used in Flow cytometry/Cell sorting to study the function of the neonatal imprinting of stromal cells in mesenteric lymph nodes.

Tue Sep 25 00:00:00 EDT 2018

Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge.

Nature communications

Yi S,Zhai J,Niu R,Zhu G,Wang M,Liu J,Huang H,Wang Y,Jing X,Kang L,Song W,Shi Y,Tang H

12-0112 was used in Flow cytometry/Cell sorting to suggest that different lung antigen-presenting cells modulate lung cDC1-mediated eosinophil recruitment dynamically.

Mon Sep 24 00:00:00 EDT 2018

Analysis of leukocyte transepithelial migration using an in vivo murine colonic loop model.

JCI insight

Flemming S,Luissint AC,Nusrat A,Parkos CA

12-0112 was used in Flow cytometry/Cell sorting to analyse leukocyte transepithelial migration using an in vivo murine colonic loop model.

Thu Oct 18 00:00:00 EDT 2018

Early cellular interactions and immune transcriptome profiles in human factor VIII-exposed hemophilia A mice.

Journal of thrombosis and haemostasis : JTH

Lai JD,Cartier D,Hartholt RB,Swystun LL,van Velzen AS,den Haan JMM,Hough C,Voorberg J,Lillicrap D

12-0112 was used in Flow cytometry/Cell sorting to assess cellular interactions and expression profiles in hemophilia A mice.

Thu Mar 01 00:00:00 EST 2018

Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung.

Frontiers in physiology

Lim D,Kim W,Lee C,Bae H,Kim J

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Sep 30 00:00:00 EDT 2020

Sumoylation of RORγt regulates T_H17 differentiation and thymocyte development.

Nature communications

He Z,Zhang J,Huang Z,Du Q,Li N,Zhang Q,Chen Y,Sun Z

12-0112 was used in Flow cytometry/Cell sorting to study the mechanism underlying the regulation of RORyt function.

Mon Nov 19 00:00:00 EST 2018

Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis.

The Journal of biological chemistry

Lee JA,Wang Z,Sambo D,Bunting KD,Pallas DC

Fri Jun 22 00:00:00 EDT 2018

Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow.

Nature communications

Xu C,Gao X,Wei Q,Nakahara F,Zimmerman SE,Mar J,Frenette PS

Fri Jun 22 00:00:00 EDT 2018

Necroptosis of infiltrated macrophages drives Yersinia pestis dispersal within buboes.

JCI insight

Arifuzzaman M,Ang WXG,Choi HW,Nilles ML,St John AL,Abraham SN

12-0112-82 was used in Flow Cytometry to examine how Yersinia pestis converts immunocytes recruited by host to contain the pathogen into vehicles for bacterial dispersal and the role of immune cell death in this context.

Thu Sep 20 00:00:00 EDT 2018

RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells.

The Journal of biological chemistry

Ge J,Burnier L,Adamopoulou M,Kwa MQ,Schaks M,Rottner K,Brakebusch C

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Jun 15 00:00:00 EDT 2018

Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.

Nature communications

Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K

12-0112 was used in Flow cytometry/Cell sorting to study paediatric acute myeloid leukaemia biology, and provide murine models that offer the potential for developing paediatric specific therapeutic strategies.

Tue Dec 11 00:00:00 EST 2018

CD157 Marks Tissue-Resident Endothelial Stem Cells with Homeostatic and Regenerative Properties.

Cell stem cell

Wakabayashi T,Naito H,Suehiro JI,Lin Y,Kawaji H,Iba T,Kouno T,Ishikawa-Kato S,Furuno M,Takara K,Muramatsu F,Weizhen J,Kidoya H,Ishihara K,Hayashizaki Y,Nishida K,Yoder MC,Takakura N

12-0112-82 was used in Flow cytometry/Cell sorting to show that tissue-resident VESCs display self-renewal capacity and that vascular regeneration potential exists in peripheral blood vessels.

Thu Mar 01 00:00:00 EST 2018

JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression.

Nature medicine

Zhao X,Guo Y,Jiang C,Chang Q,Zhang S,Luo T,Zhang B,Jia X,Hung MC,Dong C,Lin X

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.

Nature medicine

Giles DA,Moreno-Fernandez ME,Stankiewicz TE,Graspeuntner S,Cappelletti M,Wu D,Mukherjee R,Chan CC,Lawson MJ,Klarquist J,Sünderhauf A,Softic S,Kahn CR,Stemmer K,Iwakura Y,Aronow BJ,Karns R,Steinbrecher KA,Karp CL,Sheridan R,Shanmukhappa SK,Reynaud D,Haslam DB,Sina C,Rupp J,Hogan SP,Divanovic S

12-0112 was used in Flow cytometry/Cell sorting to show thermoneutral housing provides a sex-independent model of exacerbated NAFLD in mice and represents a novel approach for interrogation of the cellular and molecular mechanisms underlying disease pathogenesis.

Sat Jul 01 00:00:00 EDT 2017

Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis.

Nature

Hérault A,Binnewies M,Leong S,Calero-Nieto FJ,Zhang SY,Kang YA,Wang X,Pietras EM,Chu SH,Barry-Holson K,Armstrong S,Göttgens B,Passegué E

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Apr 06 00:00:00 EDT 2017

A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma.

Nature

Tammela T,Sanchez-Rivera FJ,Cetinbas NM,Wu K,Joshi NS,Helenius K,Park Y,Azimi R,Kerper NR,Wesselhoeft RA,Gu X,Schmidt L,Cornwall-Brady M,Yilmaz ÖH,Xue W,Katajisto P,Bhutkar A,Jacks T

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu May 18 00:00:00 EDT 2017

Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production.

Immunity

Dalmas E,Lehmann FM,Dror E,Wueest S,Thienel C,Borsigova M,Stawiski M,Traunecker E,Lucchini FC,Dapito DH,Kallert SM,Guigas B,Pattou F,Kerr-Conte J,Maechler P,Girard JP,Konrad D,Wolfrum C,Böni-Schnetzler M,Finke D,Donath MY

12-0112 was used in Flow cytometry/Cell sorting to provide evidence that an immunometabolic crosstalk between islet-derived IL-33, ILC2s, and myeloid cells fosters insulin secretion.

Tue Nov 21 00:00:00 EST 2017

Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.

Nature immunology

Fang J,Bolanos LC,Choi K,Liu X,Christie S,Akunuru S,Kumar R,Wang D,Chen X,Greis KD,Stoilov P,Filippi MD,Maciejewski JP,Garcia-Manero G,Weirauch MT,Salomonis N,Geiger H,Zheng Y,Starczynowski DT

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration.

Cell stem cell

Ambrosi TH,Scialdone A,Graja A,Gohlke S,Jank AM,Bocian C,Woelk L,Fan H,Logan DW,Schürmann A,Saraiva LR,Schulz TJ

12-0112 was used in Flow cytometry/Cell sorting to specify the cellular identities of the adipogenic and osteogenic lineages of the bone.

Thu Jun 01 00:00:00 EDT 2017

A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.

The Journal of clinical investigation

Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

LRRK2 promotes the activation of NLRC4 inflammasome during Salmonella Typhimurium infection.

The Journal of experimental medicine

Liu W,Liu X,Li Y,Zhao J,Liu Z,Hu Z,Wang Y,Yao Y,Miller AW,Su B,Cookson MR,Li X,Kang Z

12-0112 was used in Flow cytometry/Cell sorting to report a crucial role for LRRK2 in the activcation of the NLRC4 inflammasome during host defense against Salmonella enteric serovar Typhimurium infection.

Mon Oct 02 00:00:00 EDT 2017

TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects.

The Journal of experimental medicine

Choo MK,Sano Y,Kim C,Yasuda K,Li XD,Lin X,Stenzel-Poore M,Alexopoulou L,Ghosh S,Latz E,Rifkin IR,Chen ZJ,Stewart GC,Chong H,Park JM

12-0112 was used in Flow cytometry/Cell sorting to show that the spores of Bacillus anthracis possess an intrinsic ability to induce host immune responses, attributable to high amounts of RNA in the spore surface layer.

Mon May 01 00:00:00 EDT 2017

DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.

The Journal of experimental medicine

Lehmann CHK,Baranska A,Heidkamp GF,Heger L,Neubert K,Lühr JJ,Hoffmann A,Reimer KC,Brückner C,Beck S,Seeling M,Kießling M,Soulat D,Krug AB,Ravetch JV,Leusen JHW,Nimmerjahn F,Dudziak D

12-0112 was used in Flow cytometry/Cell sorting to suggest that targeting antigens to FcγRs on DCs may be a promising approach to raise immunogenic or tolerogenic T cell responses to antigens of choice.

Mon May 01 00:00:00 EDT 2017

VEGF blockade enhances the antitumor effect of BRAFV600E inhibition.

EMBO molecular medicine

Comunanza V,Corà D,Orso F,Consonni FM,Middonti E,Di Nicolantonio F,Buzdin A,Sica A,Medico E,Sangiolo D,Taverna D,Bussolino F

12011282 was used in immunohistochemistry - frozen section to show that although targeted inhibition of either BRAF or VEGF initially suppresses the growth of BRAF-mutant tumors, combined inhibition of both pathways results in apoptosis and long-lasting tumor responses

Wed Feb 01 00:00:00 EST 2017

Deletion of PIKfyve alters alveolar macrophage populations and exacerbates allergic inflammation in mice.

The EMBO journal

Kawasaki T,Ito K,Miyata H,Akira S,Kawai T

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Jun 14 00:00:00 EDT 2017

Brd4 modulates the innate immune response through Mnk2-eIF4E pathway-dependent translational control of IκBα.

Proceedings of the National Academy of Sciences of the United States of America

Bao Y,Wu X,Chen J,Hu X,Zeng F,Cheng J,Jin H,Lin X,Chen LF

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue May 16 00:00:00 EDT 2017

CCR2^- and CCR2⁺ corneal macrophages exhibit distinct characteristics and balance inflammatory responses after epithelial abrasion.

Mucosal immunology

Liu J,Xue Y,Dong D,Xiao C,Lin C,Wang H,Song F,Fu T,Wang Z,Chen J,Pan H,Li Y,Cai D,Li Z

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Sep 01 00:00:00 EDT 2017

Dectin-2 is a primary receptor for NLRP3 inflammasome activation in dendritic cell response to Histoplasma capsulatum.

PLoS pathogens

Chang TH,Huang JH,Lin HC,Chen WY,Lee YH,Hsu LC,Netea MG,Ting JP,Wu-Hsieh BA

12-0112 was used in Flow cytometry/Cell sorting to investigate how H. capsulatum induces inflammasome activation and IL-1β production, showing that dectin-2 is a primary receptor for NLRP3 inflammasome activation.

Sat Jul 01 00:00:00 EDT 2017

Immunology

Xu F,Zhang C,Zou Z,Fan EKY,Chen L,Li Y,Billiar TR,Wilson MA,Shi X,Fan J

12-0112 was used in Flow cytometry/Cell sorting to suggest an important role of Atg5 and autophagy in maintaining the function of neutrophil extracellular trap formation.

Tue Aug 01 00:00:00 EDT 2017

Depletion of microglia exacerbates postischemic inflammation and brain injury.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Jin WN,Shi SX,Li Z,Li M,Wood K,Gonzales RJ,Liu Q

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Jun 01 00:00:00 EDT 2017

Human umbilical cord blood-borne fibroblasts contain marrow niche precursors that form a bone/marrow organoid in vivo.

Development (Cambridge, England)

Pievani A,Sacchetti B,Corsi A,Rambaldi B,Donsante S,Scagliotti V,Vergani P,Remoli C,Biondi A,Robey PG,Riminucci M,Serafini M

12-0112 was used in Flow cytometry/Cell sorting to show that human umbilical cord blood-borne fibroblasts are able to recapitulate the conditions by which the bone marrow microenvironment is formed and establish complete hematopoietic stem cell niches.

Wed Mar 15 00:00:00 EDT 2017

Lymphatic Endothelial Cells Produce M-CSF, Causing Massive Bone Loss in Mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Wang W,Wang H,Zhou X,Li X,Sun W,Dellinger M,Boyce BF,Xing L

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2017

Increased White Matter Inflammation in Aging- and Alzheimer's Disease Brain.

Frontiers in molecular neuroscience

Raj D,Yin Z,Breur M,Doorduin J,Holtman IR,Olah M,Mantingh-Otter IJ,Van Dam D,De Deyn PP,den Dunnen W,Eggen BJL,Amor S,Boddeke E

12-0112 was used in Flow cytometry/Cell sorting to indicate that microglia-induced neuroinflammation is predominant in the white matter of aging mice and humans as well as in EOAD brains.

Thu Oct 01 00:00:00 EDT 2020

Lung Epithelial Cell-Derived Microvesicles Regulate Macrophage Migration via MicroRNA-17/221-Induced Integrin β₁ Recycling.

Journal of immunology (Baltimore, Md. : 1950)

Lee H,Zhang D,Wu J,Otterbein LE,Jin Y

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Aug 15 00:00:00 EDT 2017

The Upregulation of Integrin α_Dβ₂ (CD11d/CD18) on Inflammatory Macrophages Promotes Macrophage Retention in Vascular Lesions and Development of Atherosclerosis.

Journal of immunology (Baltimore, Md. : 1950)

Aziz MH,Cui K,Das M,Brown KE,Ardell CL,Febbraio M,Pluskota E,Han J,Wu H,Ballantyne CM,Smith JD,Cathcart MK,Yakubenko VP

Thu Jun 15 00:00:00 EDT 2017

Silybin attenuates LPS-induced lung injury in mice by inhibiting NF-κB signaling and NLRP3 activation.

International journal of molecular medicine

Zhang B,Wang B,Cao S,Wang Y,Wu D

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2017

ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis.

RNA biology

Ben-Shoshan SO,Kagan P,Sultan M,Barabash Z,Dor C,Jacob-Hirsch J,Harmelin A,Pappo O,Marcu-Malina V,Ben-Ari Z,Amariglio N,Rechavi G,Goldstein I,Safran M

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu May 04 00:00:00 EDT 2017

β3-Adrenergic Regulation of EPC Features Through Manipulation of the Bone Marrow MSC Niche.

Journal of cellular biochemistry

Vafaei R,Nassiri SM,Siavashi V

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Dec 01 00:00:00 EST 2017

Coinjection of IL2 DNA enhances E7-specific antitumor immunity elicited by intravaginal therapeutic HPV DNA vaccination with electroporation.

Gene therapy

Sun Y,Peng S,Yang A,Farmer E,Wu TC,Hung CF

12-0112 was used in Flow cytometry/Cell sorting to assess the therapeutic efficacy of intravaginal immunisation with human papillomavirus pcDNA3-CRT/E7 followed by electroporation.

Sat Jul 01 00:00:00 EDT 2017

Growth inhibition of formed corneal neovascularization following Fosaprepitant treatment.

Acta ophthalmologica

Bignami F,Lorusso A,Rama P,Ferrari G

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Nov 01 00:00:00 EDT 2017

Ethanol, TLR3, and TLR4 Agonists Have Unique Innate Immune Responses in Neuron-Like SH-SY5Y and Microglia-Like BV2.

Alcoholism, clinical and experimental research

Lawrimore CJ,Crews FT

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2017

CXCL9 compensates for the absence of CXCL10 during recurrent Herpetic stromal keratitis.

Virology

Tajfirouz D,West DM,Yin XT,Potter CA,Klein R,Stuart PM

12-0112 was used in Flow cytometry/Cell sorting to study whether compensatory up-regulation of CXCL9 occurs in the absence of CXCL10.

Thu Jun 01 00:00:00 EDT 2017

Batf3-dependent CD8α⁺ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages.

EBioMedicine

Li Y,Liu X,Duan W,Tian H,Zhu G,He H,Yao S,Yi S,Song W,Tang H

12-0112 was used in Flow cytometry/Cell sorting to show that Batf3-/-Apoe-/- mice, lacking CD8α+ DCs, exhibited a significant reduction in atherogenesis and T help 1 (Th1) cells compared with Apoe-/- controls.

Sat Apr 01 00:00:00 EDT 2017

Myeloid-specific genetic ablation of ATP-binding cassette transporter ABCA1 is protective against cancer.

Oncotarget

Zamanian-Daryoush M,Lindner DJ,DiDonato JA,Wagner M,Buffa J,Rayman P,Parks JS,Westerterp M,Tall AR,Hazen SL

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Sep 22 00:00:00 EDT 2017

Armored CAR T cells enhance antitumor efficacy and overcome the tumor microenvironment.

Scientific reports

Yeku OO,Purdon TJ,Koneru M,Spriggs D,Brentjens RJ

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Sep 05 00:00:00 EDT 2017

Microvasculature remodeling in the mouse lower gut during inflammaging.

Scientific reports

Jeong JH,Kim K,Lim D,Kim KH,Kim HS,Lee S,Song JH,Moon BG,Choy HE,Park SC

12-0112 was used in Flow cytometry/Cell sorting to show that microvessels in aging mouse intestine were progressively deprived of supportive structures, microvessel-associated pericytes and adherens junction protein vascular endothelial (VE)-cadherin, and became leaky.

Tue Jan 03 00:00:00 EST 2017

MiR-125a Is a critical modulator for neutrophil development.

PLoS genetics

Qin Y,Wu L,Ouyang Y,Zhou P,Zhou H,Wang Y,Ma J,Zhang J,Chen Y,Qian J,Tang Y,Shen N

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Sun Oct 01 00:00:00 EDT 2017

Overexpression of OSM and IL-6 impacts the polarization of pro-fibrotic macrophages and the development of bleomycin-induced lung fibrosis.

Scientific reports

Ayaub EA,Dubey A,Imani J,Botelho F,Kolb MRJ,Richards CD,Ask K

12-0112 was used in Flow cytometry/Cell sorting to suggest that therapeutic strategies targeting these cytokines or their receptors may be beneficial to prevent the accumulation of M2-like macrophages and the progression of fibrotic lung disease.

Mon Oct 16 00:00:00 EDT 2017

Human amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury.

Stem cell research & therapy

Zhu D,Tan J,Maleken AS,Muljadi R,Chan ST,Lau SN,Elgass K,Leaw B,Mockler J,Chambers D,Leeman KT,Kim CF,Wallace EM,Lim R

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Nov 10 00:00:00 EST 2017

Recipient bone marrow assimilates the myeloid/lymphoid reconstitution of distinct fetal hematopoietic stem cells.

Oncotarget

Guo XL,Chu L,Ke F,Mu LL,Li Z,Cai JJ,Li HF,Hong DL

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Dec 12 00:00:00 EST 2017

Long-term consumption of sugar-sweetened beverage during the growth period promotes social aggression in adult mice with proinflammatory responses in the brain.

Scientific reports

Choi JY,Park MN,Kim CS,Lee YK,Choi EY,Chun WY,Shin DM

12-0112 was used in Flow cytometry/Cell sorting to examine the long-term effects of sugar sweetened beverages on social aggression in mice.

Mon Apr 10 00:00:00 EDT 2017

Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy.

JCI insight

Ikutani M,Tsuneyama K,Kawaguchi M,Fukuoka J,Kudo F,Nakae S,Arita M,Nagai Y,Takaki S,Takatsu K

12-0112 was used in Flow cytometry/Cell sorting to demonstrate a previously unrecognized mechanism in the development of pulmonary arterial hypertrophy and the causative roles of ILC2 in the process.

Thu Apr 06 00:00:00 EDT 2017

E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses.

Nature communications

Song Y,Lai L,Chong Z,He J,Zhang Y,Xue Y,Xie Y,Chen S,Dong P,Chen L,Chen Z,Dai F,Wan X,Xiao P,Cao X,Liu Y,Wang Q

12-0112 was used in Flow cytometry/Cell sorting to identify FBXW7 as an important interacting partner for RIG-I.

Mon Mar 13 00:00:00 EDT 2017

Human amnion epithelial cells rescue cell death via immunomodulation of microglia in a mouse model of perinatal brain injury.

Stem cell research & therapy

Leaw B,Zhu D,Tan J,Muljadi R,Saad MI,Mockler JC,Wallace EM,Lim R,Tolcos M

12-0112 was used in Flow cytometry/Cell sorting to demonstrate that human amnion epithelial cells can directly immunomodulate brain microglia, likely via release of trophic factors.

Tue Feb 28 00:00:00 EST 2017

Granulocyte colony-stimulating factor blockade enables dexamethasone to inhibit lipopolysaccharide-induced murine lung neutrophils.

PloS one

Banuelos J,Cao Y,Shin SC,Bochner BS,Avila P,Li S,Jiang X,Lingen MW,Schleimer RP,Lu NZ

12-0112 was used in Flow cytometry/Cell sorting to determine the role of granulocyte colony-stimulating factor in mouse lung neutrophil numbers, in the absence and presence of dexamethasone (a potent glucocorticoid).

Wed Oct 04 00:00:00 EDT 2017

Loss of epidermal AP1 transcription factor function reduces filaggrin level, alters chemokine expression and produces an ichthyosis-related phenotype.

Cell death & disease

Young CA,Rorke EA,Adhikary G,Xu W,Eckert RL

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Jun 01 00:00:00 EDT 2017

Neutrophil swarming and extracellular trap formation play a significant role in Alum adjuvant activity.

NPJ vaccines

Stephen J,Scales HE,Benson RA,Erben D,Garside P,Brewer JM

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Apr 08 00:00:00 EDT 2022

CD36 receptor regulates malaria-induced immune responses primarily at early blood stage infection contributing to parasitemia control and resistance to mortality.

The Journal of biological chemistry

Thylur RP,Wu X,Gowda NM,Punnath K,Neelgund SE,Febbraio M,Gowda DC

Fri Jun 02 00:00:00 EDT 2017

Toxoplasma Co-infection Prevents Th2 Differentiation and Leads to a Helminth-Specific Th1 Response.

Frontiers in cellular and infection microbiology

Ahmed N,French T,Rausch S,Kühl A,Hemminger K,Dunay IR,Steinfelder S,Hartmann S

12-0112 was used in Flow cytometry/Cell sorting to conclude a previous T. gondii infection limits a helminth-specific Th2 immune response while promoting a shift toward a Th1-type immune response.

Mon Apr 02 00:00:00 EDT 2018

In vivo quantification of quantum dot systemic transport in C57BL/6 hairless mice following skin application post-ultraviolet radiation.

Particle and fibre toxicology

Jatana S,Palmer BC,Phelan SJ,Gelein R,DeLouise LA

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Apr 14 00:00:00 EDT 2017

Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps.

JCI insight

Kienhöfer D,Hahn J,Stoof J,Csepregi JZ,Reinwald C,Urbonaviciute V,Johnsson C,Maueröder C,Podolska MJ,Biermann MH,Leppkes M,Harrer T,Hultqvist M,Olofsson P,Munoz LE,Mocsai A,Herrmann M,Schett G,Holmdahl R,Hoffmann MH

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu May 18 00:00:00 EDT 2017

Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation.

Nature communications

Xu Y,Wang Y,Yan S,Yang Q,Zhou Y,Zeng X,Liu Z,An X,Toque HA,Dong Z,Jiang X,Fulton DJ,Weintraub NL,Li Q,Bagi Z,Hong M,Boison D,Wu C,Huo Y

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Oct 16 00:00:00 EDT 2017

CIITA-driven MHC class II expressing tumor cells can efficiently prime naive CD4⁺ TH cells in vivo and vaccinate the host against parental MHC-II-negative tumor cells.

Oncoimmunology

Bou Nasser Eddine F,Forlani G,Lombardo L,Tedeschi A,Tosi G,Accolla RS

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

Blocking IL-10 signalling at the time of immunization does not increase unwanted side effects in mice.

BMC immunology

Ni G,Liao Z,Chen S,Wang T,Yuan J,Pan X,Mounsey K,Cavezza S,Liu X,Wei MQ

12-0112 was used in Flow cytometry/Cell sorting to determine the effect of blocking IL-10 during immunisation on intestinal inflammation responses.

Tue Aug 15 00:00:00 EDT 2017

Fractional laser exposure induces neutrophil infiltration (N1 phenotype) into the tumor and stimulates systemic anti-tumor immune response.

PloS one

Kawakubo M,Demehri S,Manstein D

12-0112 was used in Flow cytometry/Cell sorting to explore the utility of ablative fractional photothermolysis in treating oncological indications, including induction of local tumour regression and inducing anti-tumour immunity.

Fri Oct 13 00:00:00 EDT 2017

Tumor-associated macrophages promote neuroblastoma via STAT3 phosphorylation and up-regulation of c-MYC.

Oncotarget

Hadjidaniel MD,Muthugounder S,Hung LT,Sheard MA,Shirinbak S,Chan RY,Nakata R,Borriello L,Malvar J,Kennedy RJ,Iwakura H,Akamizu T,Sposto R,Shimada H,DeClerck YA,Asgharzadeh S

12-0112 was used in Flow cytometry/Cell sorting to indicate a novel role of tumour-associated macrophages as inducers of MYC expression in neuroblastomas lacking independent oncogene activation.

Tue Oct 31 00:00:00 EDT 2017

Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer.

JCI insight

Sato-Kaneko F,Yao S,Ahmadi A,Zhang SS,Hosoya T,Kaneda MM,Varner JA,Pu M,Messer KS,Guiducci C,Coffman RL,Kitaura K,Matsutani T,Suzuki R,Carson DA,Hayashi T,Cohen EE

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Sep 21 00:00:00 EDT 2017

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.

Cell

Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Oct 06 00:00:00 EDT 2016

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.

Cell

Damgaard RB,Walker JA,Marco-Casanova P,Morgan NV,Titheradge HL,Elliott PR,McHale D,Maher ER,McKenzie ANJ,Komander D

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Aug 25 00:00:00 EDT 2016

Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation.

Cell

Wang A,Huen SC,Luan HH,Yu S,Zhang C,Gallezot JD,Booth CJ,Medzhitov R

12-0112 was used in an ELISA assay to analyse the effects of anorxia in mouse models wih viral and bacterial infections.

Thu Sep 08 00:00:00 EDT 2016

Dendritic Cells Regulate Extrafollicular Autoreactive B Cells via T Cells Expressing Fas and Fas Ligand.

Immunity

Ols ML,Cullen JL,Turqueti-Neves A,Giles J,Shlomchik MJ

12-0112 was used in Flow cytometry/Cell sorting to investigate the role of conventional dendritic cells on a classical Toll-like receptor-dependent autoreactive extrafollicular response elicited in rheumatoid-factor B cells by DNA-containing immune complexes.

Tue Nov 15 00:00:00 EST 2016

Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses.

Cancer cell

Young A,Ngiow SF,Barkauskas DS,Sult E,Hay C,Blake SJ,Huang Q,Liu J,Takeda K,Teng MWL,Sachsenmeier K,Smyth MJ

12-0112 was used in Flow cytometry/Cell sorting to identify that co-blockade of the ectonucleotidase that generates adenosine CD73 and the A2A adenosine receptor that mediates adenosine signalling in leuokocytes limits tumour initiation, growth and metastasis.

Mon Sep 12 00:00:00 EDT 2016

Classical dendritic cells are required for dietary antigen-mediated induction of peripheral T(reg) cells and tolerance.

Nature immunology

Esterházy D,Loschko J,London M,Jove V,Oliveira TY,Mucida D

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2016

Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1β.

Journal of hepatology

Ilyas G,Zhao E,Liu K,Lin Y,Tesfa L,Tanaka KE,Czaja MJ

12-0112 was used in Flow cytometry/Cell sorting to show that macrophage autophagy functions to limit acute toxin-induced liver injury and death by inhibiting the generation of inflammasome-dependent IL-1β.

Fri Jan 01 00:00:00 EST 2016

Oligodendrocyte death results in immune-mediated CNS demyelination.

Nature neuroscience

Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

The breast tumor microenvironment alters the phenotype and function of natural killer cells.

Cellular & molecular immunology

Krneta T,Gillgrass A,Chew M,Ashkar AA

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2016

PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.

The Journal of clinical investigation

Cole CB,Verdoni AM,Ketkar S,Leight ER,Russler-Germain DA,Lamprecht TL,Demeter RT,Magrini V,Ley TJ

12-0112 was used in Flow cytometry/Cell sorting to suggest that PML-RARA requires DNMT3A to initiate acute promyelocytic leukemia in mice.

Fri Jan 01 00:00:00 EST 2016

Alternatively activated macrophages determine repair of the infarcted adult murine heart.

The Journal of clinical investigation

Shiraishi M,Shintani Y,Shintani Y,Ishida H,Saba R,Yamaguchi A,Adachi H,Yashiro K,Suzuki K

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Jun 01 00:00:00 EDT 2016

The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation.

Nucleic acids research

Tiedje C,Diaz-Muñoz MD,Trulley P,Ahlfors H,Laaß K,Blackshear PJ,Turner M,Gaestel M

12-0112 was used in Flow cytometry/Cell sorting to uncover a role of TTP as a suppressor of feedback inhibitors of inflammation and highlight the importance of TTP activity-regulation by MK2 to control the pro-inflammatory response.

Tue Sep 06 00:00:00 EDT 2016

Complement receptor 3 mediates renal protection in experimental C3 glomerulopathy.

Kidney international

Barbour TD,Ling GS,Ruseva MM,Fossati-Jimack L,Cook HT,Botto M,Pickering MC

12-0112 was used in Flow cytometry/Cell sorting to explore the protective role of CR3 in glomerulonephritis and assess whether pharmacological potentiation of a CR3 interaction with iC3b could represent a novel therapeutic approach to C3 glomerulopathy.

Fri Apr 01 00:00:00 EDT 2016

ATP-Induced Inflammasome Activation and Pyroptosis Is Regulated by AMP-Activated Protein Kinase in Macrophages.

Frontiers in immunology

Zha QB,Wei HX,Li CG,Liang YD,Xu LH,Bai WJ,Pan H,He XH,Ouyang DY

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Nov 20 00:00:00 EST 2019

Opposite Effects of Coinjection and Distant Injection of Mesenchymal Stem Cells on Breast Tumor Cell Growth.

Stem cells translational medicine

Zheng H,Zou W,Shen J,Xu L,Wang S,Fu YX,Fan W

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2016

Opposite Effects of Coinjection and Distant Injection of Mesenchymal Stem Cells on Breast Tumor Cell Growth.

Stem cells translational medicine

Zheng H,Zou W,Shen J,Xu L,Wang S,Fu YX,Fan W

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2016

Blockade of MK2 is protective in inflammation-associated colorectal cancer development.

International journal of cancer

Ray AL,Castillo EF,Morris KT,Nofchissey RA,Weston LL,Samedi VG,Hanson JA,Gaestel M,Pinchuk IV,Beswick EJ

12-0112 was used in Flow cytometry/Cell sorting to investigate the role of MAPK-activated protein kinase 2 in development of colitis-associated colon cancer.

Mon Feb 01 00:00:00 EST 2016

Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.

Immunology

Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Sat Oct 01 00:00:00 EDT 2016

Ginsenoside Rd alleviates mouse acute renal ischemia/reperfusion injury by modulating macrophage phenotype.

Journal of ginseng research

Ren K,Jin C,Ma P,Ren Q,Jia Z,Zhu D

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Apr 01 00:00:00 EDT 2016

Multimodal analysis of ocular inflammation using the endotoxin-induced uveitis mouse model.

Disease models & mechanisms

Chu CJ,Gardner PJ,Copland DA,Liyanage SE,Gonzalez-Cordero A,Kleine Holthaus SM,Luhmann UF,Smith AJ,Ali RR,Dick AD

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Apr 01 00:00:00 EDT 2016

Cardiac Tissue Injury and Remodeling Is Dependent Upon MR Regulation of Activation Pathways in Cardiac Tissue Macrophages.

Endocrinology

Shen JZ,Morgan J,Tesch GH,Rickard AJ,Chrissobolis S,Drummond GR,Fuller PJ,Young MJ

12-0112 was used in Flow cytometry/Cell sorting to determine the cellular mechanisms of macrophage mineralocorticoid receptor signaling in isolated tissue macrophages.

Mon Aug 01 00:00:00 EDT 2016

Model-Based Characterization of Inflammatory Gene Expression Patterns of Activated Macrophages.

PLoS computational biology

Rex J,Albrecht U,Ehlting C,Thomas M,Zanger UM,Sawodny O,Häussinger D,Ederer M,Feuer R,Bode JG

12-0112 was used in Flow cytometry/Cell sorting to investigate inflammatory gene expression patterns of activated macrophages via model-based characterization.

Fri Jul 01 00:00:00 EDT 2016

ECM-Dependence of Endothelial Progenitor Cell Features.

Journal of cellular biochemistry

Siavashi V,Nassiri SM,Rahbarghazi R,Vafaei R,Sariri R

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

The miR-17∼92 cluster contributes to MLL leukemia through the repression of MEIS1 competitor PKNOX1.

Leukemia research

Mian YA,Zeleznik-Le NJ

12-0112 was used in Flow cytometry/Cell sorting to show that the miR-17∼92 cluster is part of a regulatory mechanism necessary to maintain MEIS1/HOXA9 -mediated transformation in MLL leukemia.

Fri Jul 01 00:00:00 EDT 2016

Real-Time Imaging of Interactions of Neutrophils with Cryptococcus neoformans Demonstrates a Crucial Role of Complement C5a-C5aR Signaling.

Infection and immunity

Sun D,Zhang M,Liu G,Wu H,Zhu X,Zhou H,Shi M

12-0112 was used in Flow cytometry/Cell sorting to characterise the dynamic interactions of neutrophils with C. neoformans, showing a crucial role of complement C5a-C5aR signalling.

Fri Jan 01 00:00:00 EST 2016

Sertoli cell condition medium can induce germ like cells from bone marrow derived mesenchymal stem cells.

Iranian journal of basic medical sciences

Monfared MH,Minaee B,Rastegar T,Khrazinejad E,Barbarestani M

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Nov 01 00:00:00 EDT 2016

Deficiency of the TLR4 analogue RP105 aggravates vein graft disease by inducing a pro-inflammatory response.

Scientific reports

Wezel A,de Vries MR,Maassen JM,Kip P,Peters EA,Karper JC,Kuiper J,Bot I,Quax PHA

12-0112 was used in Flow cytometry/Cell sorting to determine aggravated vein graft disease caused by RP105 deficiency results from an increased local inflammatory response.

Thu Apr 07 00:00:00 EDT 2016

Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.

Stem cell reports

Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Aug 09 00:00:00 EDT 2016

Evaluation of Cross-presentation in Bone Marrow-derived Dendritic Cells in vitro and Splenic Dendritic Cells ex vivo Using Antigen-coated Beads.

Bio-protocol

Alloatti A,Kotsias F,Hoffmann E,Amigorena S

12-0112 was used in Flow cytometry/Cell sorting to develop a protocol for evaluating antigen cross-presentation by dendritic cells, both in vivo and ex vivo.

Sun Nov 20 00:00:00 EST 2016

Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury.

Cell death & disease

Di Siena S,Gimmelli R,Nori SL,Barbagallo F,Campolo F,Dolci S,Rossi P,Venneri MA,Giannetta E,Gianfrilli D,Feigenbaum L,Lenzi A,Naro F,Cianflone E,Mancuso T,Torella D,Isidori AM,Pellegrini M

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Jul 28 00:00:00 EDT 2016

Erythropoietin treatment in murine multiple myeloma: immune gain and bone loss.

Scientific reports

Deshet-Unger N,Hiram-Bab S,Haim-Ohana Y,Mittelman M,Gabet Y,Neumann D

12-0112 was used in Flow cytometry/Cell sorting to reveal that in multiple myeloma, erythropoietin may act as a double-edged sword by stimulating the immune response whilst accelerating bone resorption.

Tue Aug 02 00:00:00 EDT 2016

Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis.

PloS one

Giles DA,Moreno-Fernandez ME,Stankiewicz TE,Cappelletti M,Huppert SS,Iwakura Y,Dong C,Shanmukhappa SK,Divanovic S

12-0112 was used in Flow cytometry/Cell sorting to indicate that the IL-17 axis also plays a role in a MCDD-induced model of NAFLD pathogenesis.

Tue Jul 19 00:00:00 EDT 2016

B cell-derived transforming growth factor-β1 expression limits the induction phase of autoimmune neuroinflammation.

Scientific reports

Bjarnadóttir K,Benkhoucha M,Merkler D,Weber MS,Payne NL,Bernard CCA,Molnarfi N,Lalive PH

12-0112-82 was used in Flow Cytometry to test the role for transforming growth factor-β1 expression in regulatory B cell function in autoimmune neuroinflammation.

Thu Oct 06 00:00:00 EDT 2016

miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia.

Nature communications

Jiang X,Hu C,Arnovitz S,Bugno J,Yu M,Zuo Z,Chen P,Huang H,Ulrich B,Gurbuxani S,Weng H,Strong J,Wang Y,Li Y,Salat J,Li S,Elkahloun AG,Yang Y,Neilly MB,Larson RA,Le Beau MM,Herold T,Bohlander SK,Liu PP,Zhang J,Li Z,He C,Jin J,Hong S,Chen J

12-0112 was used in Flow cytometry/Cell sorting to investigate the anti-tumourigenic role of miR-22, showing that it has an anti-tumour role in acute myeloid leukaemia.

Tue Apr 26 00:00:00 EDT 2016

Ranitidine modifies myeloid cell populations and inhibits breast tumor development and spread in mice.

Oncoimmunology

Vila-Leahey A,Oldford SA,Marignani PA,Wang J,Haidl ID,Marshall JS

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Jul 01 00:00:00 EDT 2016

Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice.

American journal of physiology. Endocrinology and metabolism

Liu Y,Almeida M,Weinstein RS,O'Brien CA,Manolagas SC,Jilka RL

12-0112-82 was used in Flow cytometry/Cell sorting to provide evidence that HFD-induced bone loss in adult ApoE-KO mice is the result of compromised osteoblast supply and bone formation.

Sun May 01 00:00:00 EDT 2016

Interleukin 6 regulates psoriasiform inflammation-associated thrombosis.

JCI insight

Wang Y,Golden JB,Fritz Y,Zhang X,Diaconu D,Camhi MI,Gao H,Dawes SM,Xing X,Ganesh SK,Gudjonsson JE,Simon DI,McCormick TS,Ward NL

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Dec 08 00:00:00 EST 2016

Induction of Suppressor Cells and Increased Tumor Growth following Chronic Psychosocial Stress in Male Mice.

PloS one

Schmidt D,Peterlik D,Reber SO,Lechner A,Männel DN

12-0112 was used in Flow cytometry/Cell sorting to observe the immunological effects of chronic psychosocial stress in mice.

Fri Aug 18 00:00:00 EDT 2017

Haematopoietic ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability.

Nature communications

Leiva M,Quintana JA,Ligos JM,Hidalgo A

12-0112 was used in Flow cytometry/Cell sorting to investigate the mechanisms of life-long maintenance of HSPCs, showing that ESL-1 enables stem cell proliferation in the bone marrow by limiting TGFβ availability.

Fri Jan 08 00:00:00 EST 2016

Stroke sensitivity in the aged: sex chromosome complement vs. gonadal hormones.

Aging

McCullough LD,Mirza MA,Xu Y,Bentivegna K,Steffens EB,Ritzel R,Liu F

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Jul 01 00:00:00 EDT 2016

NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation.

Nature communications

Yang M,Chen S,Du J,He J,Wang Y,Li Z,Liu G,Peng W,Zeng X,Li D,Xu P,Guo W,Chang Z,Wang S,Tian Z,Dong Z

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Sep 07 00:00:00 EDT 2016

The impact of ranitidine on monocyte responses in the context of solid tumors.

Oncotarget

Vila-Leahey A,Rogers D,Marshall JS

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Mar 08 00:00:00 EST 2016

Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity.

JCI insight

Wang X,Cao Q,Yu L,Shi H,Xue B,Shi H

12-0112 was used in Flow cytometry/Cell sorting to investigate the underlying mechanism of obesity-induced inflammation and insulin resistance associated with activated M1 ATMs and decreased M2 ATMs.

Thu Nov 17 00:00:00 EST 2016

Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice.

Scientific reports

Watari K,Shibata T,Nabeshima H,Shinoda A,Fukunaga Y,Kawahara A,Karasuyama K,Fukushi J,Iwamoto Y,Kuwano M,Ono M

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Jan 18 00:00:00 EST 2016

Irradiation of necrotic cancer cells, employed for pulsing dendritic cells (DCs), potentiates DC vaccine-induced antitumor immunity against high-grade glioma.

Oncoimmunology

Vandenberk L,Garg AD,Verschuere T,Koks C,Belmans J,Beullens M,Agostinis P,De Vleeschouwer S,Van Gool SW

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2016

Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program.

Scientific reports

Kwon HK,Kim GC,Hwang JS,Kim Y,Chae CS,Nam JH,Jun CD,Rudra D,Surh CD,Im SH

12-0112 was used in Flow cytometry/Cell sorting to suggest that NFAT1 switches on activation induced cell death in CD4+/CD8+ T cells to maintain peripheral tolerance and prevent inflammatory skin disease.

Mon Jan 18 00:00:00 EST 2016

Anti-apoptotic Bcl-XL but not Mcl-1 contributes to protection against virus-induced apoptosis.

Cell death & disease

Ohmer M,Weber A,Sutter G,Ehrhardt K,Zimmermann A,Häcker G

12011282 was used in flow cytometry to investigate the contributions of Mcl-1 and Bcl-XL during infection with different large DNA viruses

Thu Aug 18 00:00:00 EDT 2016

Cholera Toxin Promotes Th17 Cell Differentiation by Modulating Expression of Polarizing Cytokines and the Antigen-Presenting Potential of Dendritic Cells.

PloS one

Kang JO,Lee JB,Chang J

12-0112 was used in Flow cytometry/Cell sorting to determine how cholera toxin skews the differentiation of CD4 T cells to form IL-17-producing Th17 cells.

Tue Aug 08 00:00:00 EDT 2017

Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.

Scientific reports

Ochi T,Feng Y,Kitamoto S,Nagao-Kitamoto H,Kuffa P,Atarashi K,Honda K,Teitelbaum DH,Kamada N

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Jun 15 00:00:00 EDT 2016

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.

Nature medicine

Shankman LS,Gomez D,Cherepanova OA,Salmon M,Alencar GF,Haskins RM,Swiatlowska P,Newman AA,Greene ES,Straub AC,Isakson B,Randolph GJ,Owens GK

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2015

P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy.

Cell research

Wang H,Hong LJ,Huang JY,Jiang Q,Tao RR,Tan C,Lu NN,Wang CK,Ahmed MM,Lu YM,Liu ZR,Shi WX,Lai EY,Wilcox CS,Han F

12-0112 was used in Flow cytometry/Cell sorting to demonstrate the role of the P2RX7 pathway in linking neurovascular inflammation to brain damage in vivo.

Mon Jun 01 00:00:00 EDT 2015

The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote T(H)17 cell-dependent emphysema.

Nature immunology

Lu W,You R,Yuan X,Yang T,Samuel EL,Marcano DC,Sikkema WK,Tour JM,Rodriguez A,Kheradmand F,Corry DB

12-0112 was used in Flow cytometry/Cell sorting to show that miR-22 expression was upregulated as a consequence of smoking and contributes to the development of emphysema.

Sun Nov 01 00:00:00 EDT 2015

Host microbiota constantly control maturation and function of microglia in the CNS.

Nature neuroscience

Erny D,Hrabě de Angelis AL,Jaitin D,Wieghofer P,Staszewski O,David E,Keren-Shaul H,Mahlakoiv T,Jakobshagen K,Buch T,Schwierzeck V,Utermöhlen O,Chun E,Garrett WS,McCoy KD,Diefenbach A,Staeheli P,Stecher B,Amit I,Prinz M

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Jul 01 00:00:00 EDT 2015

Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies.

Blood

Matthews GM,Mehdipour P,Cluse LA,Falkenberg KJ,Wang E,Roth M,Santoro F,Vidacs E,Stanley K,House CM,Rusche JR,Vakoc CR,Zuber J,Minucci S,Johnstone RW

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Nov 19 00:00:00 EST 2015

CD93 Marks a Non-Quiescent Human Leukemia Stem Cell Population and Is Required for Development of MLL-Rearranged Acute Myeloid Leukemia.

Cell stem cell

Iwasaki M,Liedtke M,Gentles AJ,Cleary ML

12-0112 was used in Flow cytometry/Cell sorting to study how CD93 expression may indicate leukaemia initiating stem cells that have a MLL gene rearrangement.

Thu Oct 01 00:00:00 EDT 2015

Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1.

The Journal of clinical investigation

Fond AM,Lee CS,Schulman IG,Kiss RS,Ravichandran KS

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Jul 01 00:00:00 EDT 2015

MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation.

The Journal of clinical investigation

Ying W,Tseng A,Chang RC,Morin A,Brehm T,Triff K,Nair V,Zhuang G,Song H,Kanameni S,Wang H,Golding MC,Bazer FW,Chapkin RS,Safe S,Zhou B

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Nov 02 00:00:00 EST 2015

Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors.

The Journal of clinical investigation

Henry CJ,Casás-Selves M,Kim J,Zaberezhnyy V,Aghili L,Daniel AE,Jimenez L,Azam T,McNamee EN,Clambey ET,Klawitter J,Serkova NJ,Tan AC,Dinarello CA,DeGregori J

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2015

STK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma.

The Journal of clinical investigation

Li W,Xiao J,Zhou X,Xu M,Hu C,Xu X,Lu Y,Liu C,Xue S,Nie L,Zhang H,Li Z,Zhang Y,Ji F,Hui L,Tao W,Wei B,Wang H

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Nov 02 00:00:00 EST 2015

Injury and subsequent regeneration of muscles for activation of local innate immunity to facilitate the development and relapse of autoimmune myositis in C57BL/6 mice.

Arthritis & rheumatology (Hoboken, N.J.)

Kimura N,Hirata S,Miyasaka N,Kawahata K,Kohsaka H

Wed Apr 01 00:00:00 EDT 2015

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination.

Brain : a journal of neurology

Natrajan MS,de la Fuente AG,Crawford AH,Linehan E,Nuñez V,Johnson KR,Wu T,Fitzgerald DC,Ricote M,Bielekova B,Franklin RJ

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2015

Hepcidin Mitigates Renal Ischemia-Reperfusion Injury by Modulating Systemic Iron Homeostasis.

Journal of the American Society of Nephrology : JASN

Scindia Y,Dey P,Thirunagari A,Liping H,Rosin DL,Floris M,Okusa MD,Swaminathan S

12-0112 was used in Flow cytometry/Cell sorting to investigate the effect of renal ischaemia-reperfusion injury on systemic iron homeostasis and determine if dynamic modulation of iron homeostasis with hepcidin has therapeutic benefit in the treatment of AKI.

Sun Nov 01 00:00:00 EDT 2015

Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil Homeostasis.

Journal of the American Society of Nephrology : JASN

Micanovic R,Chitteti BR,Dagher PC,Srour EF,Khan S,Hato T,Lyle A,Tong Y,Wu XR,El-Achkar TM

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2015

Cis-regulatory mechanisms governing stem and progenitor cell transitions.

Science advances

Johnson KD,Kong G,Gao X,Chang YI,Hewitt KJ,Sanalkumar R,Prathibha R,Ranheim EA,Dewey CN,Zhang J,Bresnick EH

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2015

Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus-specific neutralizing antibody response.

EMBO molecular medicine

Her Z,Teng TS,Tan JJ,Teo TH,Kam YW,Lum FM,Lee WW,Gabriel C,Melchiotti R,Andiappan AK,Lulla V,Lulla A,Win MK,Chow A,Biswas SK,Leo YS,Lecuit M,Merits A,Rénia L,Ng LF

12-0112 was used in Flow cytometry/Cell sorting to investigate the role of TLR3 in Chikungunya virus infection.

Thu Jan 01 00:00:00 EST 2015

Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema.

eLife

You R,Lu W,Shan M,Berlin JM,Samuel EL,Marcano DC,Sun Z,Sikkema WK,Yuan X,Song L,Hendrix AY,Tour JM,Corry DB,Kheradmand F

12-0112 was used in Flow cytometry/Cell sorting to show that insoluble nanoparticulate carbon black accumulates in human myeloid dendritic cells (mDCs) from emphysematous lung and in CD11c(+) lung antigen presenting cells of mice exposed to smoke.

Mon Oct 05 00:00:00 EDT 2015

Identification of a chronic non-neurodegenerative microglia activation state in a mouse model of peroxisomal β-oxidation deficiency.

Glia

Verheijden S,Beckers L,Casazza A,Butovsky O,Mazzone M,Baes M

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2015

Aging-like changes in the transcriptome of irradiated microglia.

Glia

Li MD,Burns TC,Kumar S,Morgan AA,Sloan SA,Palmer TD

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri May 01 00:00:00 EDT 2015

Caribbean and La Réunion Chikungunya Virus Isolates Differ in Their Capacity To Induce Proinflammatory Th1 and NK Cell Responses and Acute Joint Pathology.

Journal of virology

Teo TH,Her Z,Tan JJ,Lum FM,Lee WW,Chan YH,Ong RY,Kam YW,Leparc-Goffart I,Gallian P,Rénia L,de Lamballerie X,Ng LF

12-0112 was used in Flow cytometry/Cell sorting to demonstrate that the Caribbean CHIKV isolate has an enfeebled replication and induces a less pathogenic response in the mammalian host.

Sat Aug 01 00:00:00 EDT 2015

The Effects of Androgens on Murine Cortical Bone Do Not Require AR or ERα Signaling in Osteoblasts and Osteoclasts.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Ucer S,Iyer S,Bartell SM,Martin-Millan M,Han L,Kim HN,Weinstein RS,Jilka RL,O'Brien CA,Almeida M,Manolagas SC

12-0112 was used in Flow cytometry/Cell sorting to elucidate the mechanisms by which androgens exert their effects on the cortical compartment.

Wed Jul 01 00:00:00 EDT 2015

Differential ASC requirements reveal a key role for neutrophils and a noncanonical IL-1β response to Pseudomonas aeruginosa.

American journal of physiology. Lung cellular and molecular physiology

Patankar YR,Mabaera R,Berwin B

12-0112 was used in Immunopurification to demonstrate the physiological contribution of neutrophils as a source of IL-1β in response to P. aeruginosa infection.

Thu Oct 15 00:00:00 EDT 2015

The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection.

Antimicrobial agents and chemotherapy

Traboulsi H,Cloutier A,Boyapelly K,Bonin MA,Marsault É,Cantin AM,Richter MV

12-0112 was used in Flow cytometry/Cell sorting to investigate the anti-inflammatory and antiviral activities of isoliquiritigenin during influenza virus infection.

Thu Oct 01 00:00:00 EDT 2015

Local delivery of VEGF and SDF enhances endothelial progenitor cell recruitment and resultant recovery from ischemia.

Tissue engineering. Part A

Anderson EM,Kwee BJ,Lewin SA,Raimondo T,Mehta M,Mooney DJ

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2015

Reducing progression of experimental lupus nephritis via inhibition of the B7/CD28 signaling pathway.

Molecular medicine reports

Huang L,Kong Y,Wang J,Sun J,Shi Q,Qiu YH

12-0112 was used in an ELISA assay to demonstrate a therapeutic consequence of blocking the B7-1/CD28 signalling pathway for autoimmune disorders.

Tue Sep 01 00:00:00 EDT 2015

Targeted Mutation of Nuclear Bone Morphogenetic Protein 2 Impairs Secondary Immune Response in a Mouse Model.

BioMed research international

Olsen DS,Goar WA,Nichols BA,Bailey KT,Christensen SL,Merriam KR,Reynolds PR,Wilson E,Weber KS,Bridgewater LC

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

Inhibition of NOX2 reduces locomotor impairment, inflammation, and oxidative stress after spinal cord injury.

Journal of neuroinflammation

Khayrullina G,Bermudez S,Byrnes KR

12-0112 was used in Flow cytometry/Cell sorting to investigate whether NOX2 isoform plays an integral role in post-spinal cord injury inflammation and functional deficits.

Thu Sep 17 00:00:00 EDT 2015

Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion.

The Journal of biological chemistry

Pamir N,Liu NC,Irwin A,Becker L,Peng Y,Ronsein GE,Bornfeldt KE,Duffield JS,Heinecke JW

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Jun 05 00:00:00 EDT 2015

The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia.

Nature communications

Koh HS,Chang CY,Jeon SB,Yoon HJ,Ahn YH,Kim HS,Kim IH,Jeon SH,Johnson RS,Park EJ

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Mar 20 00:00:00 EDT 2015

Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1-BAP1 complex.

Nature communications

Balasubramani A,Larjo A,Bassein JA,Chang X,Hastie RB,Togher SM,Lähdesmäki H,Rao A

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Jun 22 00:00:00 EDT 2015

Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1.

PloS one

Szulzewsky F,Pelz A,Feng X,Synowitz M,Markovic D,Langmann T,Holtman IR,Wang X,Eggen BJ,Boddeke HW,Hambardzumyan D,Wolf SA,Kettenmann H

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2016

dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.

Nature communications

Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Sep 15 00:00:00 EDT 2015

Myeloid Sirtuin 2 Expression Does Not Impact Long-Term Mycobacterium tuberculosis Control.

PloS one

Cardoso F,Castro F,Moreira-Teixeira L,Sousa J,Torrado E,Silvestre R,Castro AG,Saraiva M,Pais TF

12-0112 was used in Flow cytometry/Cell sorting to demonstrate that Sirtuin 2 expression has a transitory effect in M. tuberculosis infection.

Tue Apr 19 00:00:00 EDT 2016

Metronomic cyclophosphamide eradicates large implanted GL261 gliomas by activating antitumor Cd8⁺ T-cell responses and immune memory.

Oncoimmunology

Wu J,Waxman DJ

12-0112 was used in Flow cytometry/Cell sorting to prove that single-agent chemotherapy can eradicate large, established tumours and induce long-term immune memory.

Wed Apr 01 00:00:00 EDT 2015

Targeted Gene Correction in Osteopetrotic-Induced Pluripotent Stem Cells for the Generation of Functional Osteoclasts.

Stem cell reports

Neri T,Muggeo S,Paulis M,Caldana ME,Crisafulli L,Strina D,Focarelli ML,Faggioli F,Recordati C,Scaramuzza S,Scanziani E,Mantero S,Buracchi C,Sobacchi C,Lombardo A,Naldini L,Vezzoni P,Villa A,Ficara F

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Oct 13 00:00:00 EDT 2015

Iron prevents the development of experimental cerebral malaria by attenuating CXCR3-mediated T cell chemotaxis.

PloS one

Van Den Ham KM,Shio MT,Rainone A,Fournier S,Krawczyk CM,Olivier M

12-0112 was used in Flow cytometry/Cell sorting to study the effect of iron in attenuating CXCR3-mediated T cell chemotaxis and migration to the brain and therefore inhibiting Experimental Cerebral Malaria pathology.

Thu Jan 21 00:00:00 EST 2016

Pathogenic Yersinia Promotes Its Survival by Creating an Acidic Fluid-Accessible Compartment on the Macrophage Surface.

PloS one

Bahnan W,Boettner DR,Westermark L,Fällman M,Schesser K

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue May 10 00:00:00 EDT 2016

Immature myeloid progenitors promote disease progression in a mouse model of Barrett's-like metaplasia.

Oncotarget

Kong J,Sai H,Crissey MA,Jhala N,Falk GW,Ginsberg GG,Abrams JA,Nakagawa H,Wang K,Rustgi AK,Wang TC,Lynch JP

12-0112 was used in Flow cytometry/Cell sorting to investigate whether esophageal Cdx2 expression would accelerate the onset of metaplasia in a mouse model of Barrett's-like metaplasia.

Tue Oct 20 00:00:00 EDT 2015

Severity of DSS-induced colitis is reduced in Ido1-deficient mice with down-regulation of TLR-MyD88-NF-kB transcriptional networks.

Scientific reports

Shon WJ,Lee YK,Shin JH,Choi EY,Shin DM

12-0112 was used in Flow cytometry/Cell sorting to explore the role of IDO1 in producing inflammatory responses and modulating transcriptional networks during the development of colitis.

Fri Nov 27 00:00:00 EST 2015

Glycoprotein Nonmetastatic Melanoma B (Gpnmb)-Positive Macrophages Contribute to the Balance between Fibrosis and Fibrolysis during the Repair of Acute Liver Injury in Mice.

PloS one

Kumagai K,Tabu K,Sasaki F,Takami Y,Morinaga Y,Mawatari S,Hashimoto S,Tanoue S,Kanmura S,Tamai T,Moriuchi A,Uto H,Tsubouchi H,Ido A

12-0112 was used in Flow cytometry/Cell sorting to identify the immune cells which respond to acute liver injury and assess their contribution to the repair process.

Mon Jun 20 00:00:00 EDT 2016

Endothelial Gata5 transcription factor regulates blood pressure.

Nature communications

Messaoudi S,He Y,Gutsol A,Wight A,Hébert RL,Vilmundarson RO,Makrigiannis AP,Chalmers J,Hamet P,Tremblay J,McPherson R,Stewart AFR,Touyz RM,Nemer M

12-0112 was used in Flow cytometry/Cell sorting to study the aetiology of human hypertension, showing that GATA5, an endothelial transcription factor, regulates blood pressure, allowing the development of a new animal model of hypertension for further studies.

Mon Nov 30 00:00:00 EST 2015

Differential Immunometabolic Phenotype in Th1 and Th2 Dominant Mouse Strains in Response to High-Fat Feeding.

PloS one

Jovicic N,Jeftic I,Jovanovic I,Radosavljevic G,Arsenijevic N,Lukic ML,Pejnovic N

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue May 03 00:00:00 EDT 2016

Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication.

Oncoimmunology

Draghiciu O,Nijman HW,Hoogeboom BN,Meijerhof T,Daemen T

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Sun Mar 01 00:00:00 EST 2015

N-acetylglucosaminyltransferase V exacerbates concanavalin A-induced hepatitis in mice.

Molecular medicine reports

Kamada Y,Sato M,Kida S,Akita M,Mizutani K,Fujii H,Sobajima T,Yoshida Y,Shinzaki S,Takamatsu S,Takehara T,Miyoshi E

12-0112-82 was used in Flow Cytometry to indicate that the aberrant expression of GnT‚V led to an increase in hepatic macrophage infiltration and enhanced ConA‚induced hepatitis.

Fri May 01 00:00:00 EDT 2015

Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity.

Nature

Westphalen K,Gusarova GA,Islam MN,Subramanian M,Cohen TS,Prince AS,Bhattacharya J

12-0112 was used in Flow cytometry/Cell sorting to show that a subset of alveolar macrophages (AMs) attached to the alveolar wall form connexin 43 (Cx43)-containing gap junction channels with the epithelium.

Thu Feb 27 00:00:00 EST 2014

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.

Nature

Colegio OR,Chu NQ,Szabo AL,Chu T,Rhebergen AM,Jairam V,Cyrus N,Brokowski CE,Eisenbarth SC,Phillips GM,Cline GW,Phillips AJ,Medzhitov R

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Sep 25 00:00:00 EDT 2014

Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages.

Cell

Haldar M,Kohyama M,So AY,Kc W,Wu X,Briseño CG,Satpathy AT,Kretzer NM,Arase H,Rajasekaran NS,Wang L,Egawa T,Igarashi K,Baltimore D,Murphy TL,Murphy KM

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Mar 13 00:00:00 EDT 2014

CD4+ T cells promote the transition from hypertrophy to heart failure during chronic pressure overload.

Circulation

Laroumanie F,Douin-Echinard V,Pozzo J,Lairez O,Tortosa F,Vinel C,Delage C,Calise D,Dutaur M,Parini A,Pizzinat N

12-0112 was used in Flow cytometry/Cell sorting to investigate the involvement of T cells in the progression to heart failure using a transverse aortic constriction (TAC) model.

Tue May 27 00:00:00 EDT 2014

A role for the ITAM signaling module in specifying cytokine-receptor functions.

Nature immunology

Bezbradica JS,Rosenstein RK,DeMarco RA,Brodsky I,Medzhitov R

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Apr 01 00:00:00 EDT 2014

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.

Nature immunology

Franklin BS,Bossaller L,De Nardo D,Ratter JM,Stutz A,Engels G,Brenker C,Nordhoff M,Mirandola SR,Al-Amoudi A,Mangan MS,Zimmer S,Monks BG,Fricke M,Schmidt RE,Espevik T,Jones B,Jarnicki AG,Hansbro PM,Busto P,Marshak-Rothstein A,Hornemann S,Aguzzi A,Kastenmüller W,Latz E

12-0112 was used in Flow cytometry/Cell sorting to study the behaviour of ASC specks and their contribution to IL-1β - induced inflammation.

Fri Aug 01 00:00:00 EDT 2014

Foxp3+ CD4+ T cells improve healing after myocardial infarction by modulating monocyte/macrophage differentiation.

Circulation research

Weirather J,Hofmann UD,Beyersdorf N,Ramos GC,Vogel B,Frey A,Ertl G,Kerkau T,Frantz S

12-0112 was used in Flow cytometry/Cell sorting to determine the mechanisms by which regulatory T cells promote an appropriate healing response after a heart attack.

Fri Jun 20 00:00:00 EDT 2014

Agonistic induction of PPARγ reverses cigarette smoke-induced emphysema.

The Journal of clinical investigation

Shan M,You R,Yuan X,Frazier MV,Porter P,Seryshev A,Hong JS,Song LZ,Zhang Y,Hilsenbeck S,Whitehead L,Zarinkamar N,Perusich S,Corry DB,Kheradmand F

12-0112 was used in Flow cytometry/Cell sorting to reveal a proinflammatory pathway, in which reduced PPARγ activity promotes emphysema.

Sat Mar 01 00:00:00 EST 2014

T-cell immunoglobulin and mucin domain 4 (TIM-4) signaling in innate immune-mediated liver ischemia-reperfusion injury.

Hepatology (Baltimore, Md.)

Ji H,Liu Y,Zhang Y,Shen XD,Gao F,Busuttil RW,Kuchroo VK,Kupiec-Weglinski JW

12-0112 was used in Immunofluorescence to demonstrate the importance of macrophage-specific TIM-4 activation in the mechanism of hepatic ischemia-reperfusion injury.

Mon Dec 01 00:00:00 EST 2014

Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis.

Autophagy

Dang S,Xu H,Xu C,Cai W,Li Q,Cheng Y,Jin M,Wang RX,Peng Y,Zhang Y,Wu C,He X,Wan B,Zhang Y

12-0112 was used in Flow cytometry/Cell sorting to study how inflammatory microenvironment-induced autophagy can downregulate the immunosuppressive function of mesenchymal stem cells.

Tue Jul 01 00:00:00 EDT 2014

RAGE expression in tumor-associated macrophages promotes angiogenesis in glioma.

Cancer research

Chen X,Zhang L,Zhang IY,Liang J,Wang H,Ouyang M,Wu S,da Fonseca ACC,Weng L,Yamamoto Y,Yamamoto H,Natarajan R,Badie B

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Dec 15 00:00:00 EST 2014

BMP4 inhibits breast cancer metastasis by blocking myeloid-derived suppressor cell activity.

Cancer research

Cao Y,Slaney CY,Bidwell BN,Parker BS,Johnstone CN,Rautela J,Eckhardt BL,Anderson RL

12-0112 was used in Flow cytometry/Cell sorting to assess the potential for therapies based on the activation of BMP4 signalling for the treatment of breast cancer.

Mon Sep 15 00:00:00 EDT 2014

Protective role for Toll-like receptor-9 in the development of atherosclerosis in apolipoprotein E-deficient mice.

Arteriosclerosis, thrombosis, and vascular biology

Koulis C,Chen YC,Hausding C,Ahrens I,Kyaw TS,Tay C,Allen T,Jandeleit-Dahm K,Sweet MJ,Akira S,Bobik A,Peter K,Agrotis A

12-0112 was used in Flow cytometry/Cell sorting to investigate whether TLR9 has a role in the development of atherosclerosis in apolipoprotein E-deficient mice.

Sat Mar 01 00:00:00 EST 2014

S100a8/a9 released by CD11b+Gr1+ neutrophils activates cardiac fibroblasts to initiate angiotensin II-Induced cardiac inflammation and injury.

Hypertension (Dallas, Tex. : 1979)

Wu Y,Li Y,Zhang C,A X,Wang Y,Cui W,Li H,Du J

12-0112 was used in Flow cytometry/Cell sorting to elucidate the initial factors that trigger the inflammatory cascade during angiotensin II-induced cardiovascular injury.

Sun Jun 01 00:00:00 EDT 2014

Macrophages contribute to the cyclic activation of adult hair follicle stem cells.

PLoS biology

Castellana D,Paus R,Perez-Moreno M

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Dec 01 00:00:00 EST 2014

Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma.

Science signaling

Kusne Y,Carrera-Silva EA,Perry AS,Rushing EJ,Mandell EK,Dietrich JD,Errasti AE,Gibbs D,Berens ME,Loftus JC,Hulme C,Yang W,Lu Z,Aldape K,Sanai N,Rothlin CV,Ghosh S

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Aug 12 00:00:00 EDT 2014

Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma.

Science signaling

Kusne Y,Carrera-Silva EA,Perry AS,Rushing EJ,Mandell EK,Dietrich JD,Errasti AE,Gibbs D,Berens ME,Loftus JC,Hulme C,Yang W,Lu Z,Aldape K,Sanai N,Rothlin CV,Ghosh S

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Aug 12 00:00:00 EDT 2014

A novel 1,2-benzenediamine derivative FC-99 suppresses TLR3 expression and ameliorates disease symptoms in a mouse model of sepsis.

British journal of pharmacology

Gong W,Hu E,Dou H,Song Y,Yang L,Ji J,Li E,Tan R,Hou Y

12-0112 was used in Flow cytometry/Cell sorting to explore a 1,2-benzenediamine derivative FC-99 as a therapeutic candidate for sepsis.

Sat Nov 01 00:00:00 EDT 2014

Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice.

Glia

Cekanaviciute E,Fathali N,Doyle KP,Williams AM,Han J,Buckwalter MS

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Aug 01 00:00:00 EDT 2014

Reactive oxygen species deficiency induces autoimmunity with type 1 interferon signature.

Antioxidants & redox signaling

Kelkka T,Kienhöfer D,Hoffmann M,Linja M,Wing K,Sareila O,Hultqvist M,Laajala E,Chen Z,Vasconcelos J,Neves E,Guedes M,Marques L,Krönke G,Helminen M,Kainulainen L,Olofsson P,Jalkanen S,Lahesmaa R,Souto-Carneiro MM,Holmdahl R

12-0112 was used in Flow cytometry/Cell sorting to explore the connection between reactive oxygen species deficiencies and increased susceptibility to autoimmunity.

Mon Dec 01 00:00:00 EST 2014

A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification.

Development (Cambridge, England)

Gilmour J,Assi SA,Jaegle U,Kulu D,van de Werken H,Clarke D,Westhead DR,Philipsen S,Bonifer C

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Sun Jun 01 00:00:00 EDT 2014

Recognition of Salmonella by Dectin-1 induces presentation of peptide antigen to type B T cells.

European journal of immunology

Jackson N,Compton E,Trowsdale J,Kelly AP

12-0112 was used in Flow cytometry/Cell sorting to show that interaction of Salmonella Typhimurium with bone marrow derived dendritic cells results in enhanced presentation of peptide Ag to type B T cells.

Tue Apr 01 00:00:00 EDT 2014

Depletion of myeloid-derived suppressor cells during interleukin-12 immunogene therapy does not confer a survival advantage in experimental malignant glioma.

Cancer gene therapy

Thaci B,Ahmed AU,Ulasov IV,Wainwright DA,Nigam P,Auffinger B,Tobias AL,Han Y,Zhang L,Moon KS,Lesniak MS

12-0112 was used in Flow cytometry/Cell sorting to investigate how MDSC depletion can affect glioma immunotherapy, showing that it does not confer a survival advantage.

Wed Jan 01 00:00:00 EST 2014

Distinct spatial distribution of microglia and macrophages following mesenchymal stem cell implantation in mouse brain.

Immunology and cell biology

Le Blon D,Hoornaert C,Daans J,Santermans E,Hens N,Goossens H,Berneman Z,Ponsaerts P

12-0112 was used in Flow cytometry/Cell sorting to characterise the distribution of microglia and macrophages in the mouse brain following mesenchymal stem cell implantation, showing that resident immune cells surround the graft site while peripheral immune cells invade the graft.

Mon Sep 01 00:00:00 EDT 2014

Kinetics of IFN-γ and IL-17 Production by CD4 and CD8 T Cells during Acute Graft-versus-Host Disease.

Immune network

Ju JM,Lee H,Oh K,Lee DS,Choi EY

12-0112 was used in Flow cytometry/Cell sorting to study production of IFN-γ and IL-17 by CD4 and CD8 T cells during graft-versus-host disease progression.

Tue Apr 01 00:00:00 EDT 2014

Tracking the elusive fibrocyte: identification and characterization of collagen-producing hematopoietic lineage cells during murine wound healing.

Stem cells (Dayton, Ohio)

Suga H,Rennert RC,Rodrigues M,Sorkin M,Glotzbach JP,Januszyk M,Fujiwara T,Longaker MT,Gurtner GC

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu May 01 00:00:00 EDT 2014

Tryptophan catabolism restricts IFN-γ-expressing neutrophils and Clostridium difficile immunopathology.

Journal of immunology (Baltimore, Md. : 1950)

El-Zaatari M,Chang YM,Zhang M,Franz M,Shreiner A,McDermott AJ,van der Sluijs KF,Lutter R,Grasberger H,Kamada N,Young VB,Huffnagle GB,Kao JY

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Jul 15 00:00:00 EDT 2014

Priming of microglia in a DNA-repair deficient model of accelerated aging.

Neurobiology of aging

Raj DD,Jaarsma D,Holtman IR,Olah M,Ferreira FM,Schaafsma W,Brouwer N,Meijer MM,de Waard MC,van der Pluijm I,Brandt R,Kreft KL,Laman JD,de Haan G,Biber KP,Hoeijmakers JH,Eggen BJ,Boddeke HW

12-0112 was used in Flow cytometry/Cell sorting to study relationship between age and enhanced sensitivity of microglia to inflammatory stimuli.

Mon Sep 01 00:00:00 EDT 2014

Depletion of tumor-associated macrophages enhances the anti-tumor immunity induced by a Toll-like receptor agonist-conjugated peptide.

Human vaccines & immunotherapeutics

Shen KY,Song YC,Chen IH,Chong P,Liu SJ

12-0112 was used in Immunocytochemistry to investigate whether di-palmitoylated peptides with TLR2 agonist activity are able to induce anti-tumour immunity, showing that depletion of tumour-associated macrophages enhances the anti-tumour immunity.

Fri Oct 23 00:00:00 EDT 2015

Superantigens subvert the neutrophil response to promote abscess formation and enhance Staphylococcus aureus survival in vivo.

Infection and immunity

Xu SX,Gilmore KJ,Szabo PA,Zeppa JJ,Baroja ML,Haeryfar SM,McCormick JK

12-0112 was used in Flow cytometry/Cell sorting to study host immune responses to superantigen toxins released by S. aureus.

Mon Sep 01 00:00:00 EDT 2014

Increased expression of stress inducible protein 1 in glioma-associated microglia/macrophages.

Journal of neuroimmunology

Carvalho da Fonseca AC,Wang H,Fan H,Chen X,Zhang I,Zhang L,Lima FR,Badie B

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Sep 15 00:00:00 EDT 2014

Gene expression during the generation and activation of mouse neutrophils: implication of novel functional and regulatory pathways.

PloS one

Ericson JA,Duffau P,Yasuda K,Ortiz-Lopez A,Rothamel K,Rifkin IR,Monach PA

12-0112 was used in Flow cytometry/Cell sorting to investigate gene expression of activated and unstimulated neutrophils.

Thu Dec 17 00:00:00 EST 2015

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.

Nature communications

Chen L,Gibbons DL,Goswami S,Cortez MA,Ahn YH,Byers LA,Zhang X,Yi X,Dwyer D,Lin W,Diao L,Wang J,Roybal J,Patel M,Ungewiss C,Peng D,Antonia S,Mediavilla-Varela M,Robertson G,Suraokar M,Welsh JW,Erez B,Wistuba II,Chen L,Peng D,Wang S,Ullrich SE,Heymach JV,Kurie JM,Qin FX

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Oct 28 00:00:00 EDT 2014

Neutrophils contribute to excess serum BAFF levels and promote CD4+ T cell and B cell responses in lupus-prone mice.

PloS one

Coquery CM,Wade NS,Loo WM,Kinchen JM,Cox KM,Jiang C,Tung KS,Erickson LD

12-0112 was used in Flow cytometry/Cell sorting to analyse the phenotype, localisation and function of neutrophils in the spleens of healthy mice and congenic lupus-prone mice.

Fri Nov 06 00:00:00 EST 2015

Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy.

PloS one

Xiao GY,Liu IH,Cheng CC,Chang CC,Lee YH,Cheng WT,Wu SC

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu May 28 00:00:00 EDT 2015

Anti-tumor innate immunity activated by intermittent metronomic cyclophosphamide treatment of 9L brain tumor xenografts is preserved by anti-angiogenic drugs that spare VEGF receptor 2.

Molecular cancer

Doloff JC,Chen CS,Waxman DJ

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Jun 26 00:00:00 EDT 2014

Leukocyte population dynamics and detection of IL-9 as a major cytokine at the mouse fetal-maternal interface.

PloS one

Habbeddine M,Verbeke P,Karaz S,Bobé P,Kanellopoulos-Langevin C

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Wed Jun 10 00:00:00 EDT 2015

P2X7 receptor modulates inflammatory and functional pulmonary changes induced by silica.

PloS one

Monção-Ribeiro LC,Faffe DS,Santana PT,Vieira FS,da Graça CL,Marques-da-Silva C,Machado MN,Caruso-Neves C,Zin WA,Borojevic R,Takiya CM,Coutinho-Silva R

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Sep 17 00:00:00 EDT 2015

The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/microglia-induced inflammation.

The Journal of biological chemistry

Eitas TK,Chou WC,Wen H,Gris D,Robbins GR,Brickey J,Oyama Y,Ting JP

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Feb 14 00:00:00 EST 2014

Arteriolar niches maintain haematopoietic stem cell quiescence.

Nature

Kunisaki Y,Bruns I,Scheiermann C,Ahmed J,Pinho S,Zhang D,Mizoguchi T,Wei Q,Lucas D,Ito K,Mar JC,Bergman A,Frenette PS

12-0112 was used in Flow cytometry/Cell sorting to investigate the spatial localisation of quiescent haematopoietic stem cells in bone marrow, showing that arteriolar niches maintain quiescence.

Thu Oct 31 00:00:00 EDT 2013

miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.

Nature cell biology

Zhang Y,Yang P,Sun T,Li D,Xu X,Rui Y,Li C,Chong M,Ibrahim T,Mercatali L,Amadori D,Lu X,Xie D,Li QJ,Wang XF

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2013

HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis.

Blood

Franke K,Kalucka J,Mamlouk S,Singh RP,Muschter A,Weidemann A,Iyengar V,Jahn S,Wieczorek K,Geiger K,Muders M,Sykes AM,Poitz DM,Ripich T,Otto T,Bergmann S,Breier G,Baretton G,Fong GH,Greaves DR,Bornstein S,Chavakis T,Fandrey J,Gassmann M,Wielockx B

12-0112 was used in Flow cytometry/Cell sorting to study the regulatory effects of oxygen-sensitive prolyl hydroxylases on the process of erythropoiesis.

Thu Feb 21 00:00:00 EST 2013

A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors.

The Journal of experimental medicine

Chen YL,Chen TT,Pai LM,Wesoly J,Bluyssen HA,Lee CK

12-0112 was used in Flow cytometry/Cell sorting to define a critical role for the FL/IFN-I/Flt3 axis in plasmacytoid dendritic cell differentiation from common lymphoid progenitors.

Mon Nov 18 00:00:00 EST 2013

S100B promotes glioma growth through chemoattraction of myeloid-derived macrophages.

Clinical cancer research : an official journal of the American Association for Cancer Research

Wang H,Zhang L,Zhang IY,Chen X,Da Fonseca A,Wu S,Ren H,Badie S,Sadeghi S,Ouyang M,Warden CD,Badie B

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Jul 15 00:00:00 EDT 2013

A network of interactions enables CCM3 and STK24 to coordinate UNC13D-driven vesicle exocytosis in neutrophils.

Developmental cell

Zhang Y,Tang W,Zhang H,Niu X,Xu Y,Zhang J,Gao K,Pan W,Boggon TJ,Toomre D,Min W,Wu D

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Oct 28 00:00:00 EDT 2013

Low-dose cyclophosphamide administered as daily or single dose enhances the antitumor effects of a therapeutic HPV vaccine.

Cancer immunology, immunotherapy : CII

Peng S,Lyford-Pike S,Akpeng B,Wu A,Hung CF,Hannaman D,Saunders JR,Wu TC,Pai SI

12-0112 was used in Flow cytometry/Cell sorting to demonstrate a decreased vaccine-induced CD8(+) T-cell frequency after administration of CTX.

Tue Jan 01 00:00:00 EST 2013

Runx1 deficiency permits granulocyte lineage commitment but impairs subsequent maturation.

Oncogenesis

Ng KP,Hu Z,Ebrahem Q,Negrotto S,Lausen J,Saunthararajah Y

12-0112 was used in Flow cytometry/Cell sorting to show how Runx1-deficiency permits Cebpa upregulation and the exponential cell growth but impairs Cebpe activation, extending the exponential growth.

Mon Nov 04 00:00:00 EST 2013

Distinct development and functions of resident and recruited liver Kupffer cells/macrophages.

Journal of leukocyte biology

Ikarashi M,Nakashima H,Kinoshita M,Sato A,Nakashima M,Miyazaki H,Nishiyama K,Yamamoto J,Seki S

12-0112 was used in Flow cytometry/Cell sorting to study how liver CD68+ Kupffer cells and CD11b+ Kupffer cells/macrophages are developmentally and functionally distinct subsets.

Sun Dec 01 00:00:00 EST 2013

Arrayed lentiviral barcoding for quantification analysis of hematopoietic dynamics.

Stem cells (Dayton, Ohio)

Grosselin J,Sii-Felice K,Payen E,Chretien S,Tronik-Le Roux D,Leboulch P

12-0112-82 was used in Flow Cytometry to demonstrate arrayed lentiviral barcoding as a versatile and powerful approach to deconvolute cell dynamics in vivo with applications in hematology, embryology, and cancer biology.

Tue Oct 01 00:00:00 EDT 2013

A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL).

Disease models & mechanisms

Carofino BL,Ayanga B,Justice MJ

12-0112 was used in Flow cytometry/Cell sorting to demonstrate that increased expression of Prdm14 drives development of T-Cell acute lymphoblastic leukemia in mice.

Fri Nov 01 00:00:00 EDT 2013

IL-33 signaling regulates innate and adaptive immunity to Cryptococcus neoformans.

Journal of immunology (Baltimore, Md. : 1950)

Flaczyk A,Duerr CU,Shourian M,Lafferty EI,Fritz JH,Qureshi ST

12-0112 was used in Flow cytometry/Cell sorting to study how allergic patterns of lung inflammation are mediated as a host response to Cryptococcus neoformans infection.

Sun Sep 01 00:00:00 EDT 2013

TLR4 Signaling augments monocyte chemotaxis by regulating G protein-coupled receptor kinase 2 translocation.

Journal of immunology (Baltimore, Md. : 1950)

Liu Z,Jiang Y,Li Y,Wang J,Fan L,Scott MJ,Xiao G,Li S,Billiar TR,Wilson MA,Fan J

12-0112 was used in Flow cytometry/Cell sorting to investigate the role of TLR4 signalling in monocyte chemotaxis.

Mon Jul 15 00:00:00 EDT 2013

Prasugrel metabolites inhibit neutrophil functions.

The Journal of pharmacology and experimental therapeutics

Liverani E,Rico MC,Garcia AE,Kilpatrick LE,Kunapuli SP

12-0112 was used in Flow cytometry/Cell sorting to investigate the effect of prasugrel metabolites on neutrophils to further clarify the role of thienopyridines in inflammation.

Tue Jan 01 00:00:00 EST 2013

CD45/CD11b positive subsets of adult lung anchorage-independent cells harness epithelial stem cells in culture.

Journal of tissue engineering and regenerative medicine

Peter Y,Sen N,Levantini E,Keller S,Ingenito EP,Ciner A,Sackstein R,Shapiro SD

12-0112 was used in Flow cytometry/Cell sorting to study the relationship between stem/progenitor cells that proliferate or differentiate and somatic cells of the lung, showing anchorage-independent adult progenitor cells that do not express integrin proteins α5, β3 and β7.

Mon Jul 01 00:00:00 EDT 2013

Candida albicans stimulates in vivo differentiation of haematopoietic stem and progenitor cells towards macrophages by a TLR2-dependent signalling.

Cellular microbiology

Megías J,Maneu V,Salvador P,Gozalbo D,Gil ML

12-0112 was used in Flow cytometry/Cell sorting to report that haematopoietic stem and progenitor cells sense Candida albicans in vivo and subsequently are directed to produce macrophages by a Toll like receptor 2-dependent signalling.

Mon Jul 01 00:00:00 EDT 2013

Protective role of small pigment epithelium-derived factor (PEDF) peptide in diabetic renal injury.

American journal of physiology. Renal physiology

Awad AS,Gao T,Gvritishvili A,You H,Liu Y,Cooper TK,Reeves WB,Tombran-Tink J

12-0112 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic potential of the pigment epithelium-derived factor fragment, P78-PEDF, for diabetic nephropathy.

Sun Sep 15 00:00:00 EDT 2013

Migration of bone marrow-derived cells into the central nervous system in models of neurodegeneration.

The Journal of comparative neurology

Lampron A,Pimentel-Coelho PM,Rivest S

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Sun Dec 01 00:00:00 EST 2013

Macrophages are involved in the protective role of human umbilical cord-derived stromal cells in renal ischemia-reperfusion injury.

Stem cell research

Li W,Zhang Q,Wang M,Wu H,Mao F,Zhang B,Ji R,Gao S,Sun Z,Zhu W,Qian H,Chen Y,Xu W

12-0112 was used in Flow cytometry/Cell sorting to investigate the involvement of macrophages in the therapeutic effect of human umbilical cord-derived stromal cells on renal ischemia-reperfusion injury.

Wed May 01 00:00:00 EDT 2013

Role of NK cell subsets in organ-specific murine melanoma metastasis.

PloS one

Ballas ZK,Buchta CM,Rosean TR,Heusel JW,Shey MR

12-0112 was used in Flow cytometry/Cell sorting to examine the organ-specific functions of natural killer cells.

Thu Jan 16 00:00:00 EST 2014

The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects.

The Journal of biological chemistry

Zamanian-Daryoush M,Lindner D,Tallant TC,Wang Z,Buffa J,Klipfell E,Parker Y,Hatala D,Parsons-Wingerter P,Rayman P,Yusufishaq MSS,Fisher EA,Smith JD,Finke J,DiDonato JA,Hazen SL

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Jul 19 00:00:00 EDT 2013

The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects.

The Journal of biological chemistry

Zamanian-Daryoush M,Lindner D,Tallant TC,Wang Z,Buffa J,Klipfell E,Parker Y,Hatala D,Parsons-Wingerter P,Rayman P,Yusufishaq MSS,Fisher EA,Smith JD,Finke J,DiDonato JA,Hazen SL

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Jul 19 00:00:00 EDT 2013

Resistance to malaria by enhanced phagocytosis of erythrocytes in LMP7-deficient mice.

PloS one

Duan X,Imai T,Chou B,Tu L,Himeno K,Suzue K,Hirai M,Taniguchi T,Okada H,Shimokawa C,Hisaeda H

12-0112 was used in Flow cytometry/Cell sorting to study how RBCs of LMP7-deficient mice were more likely to deform in response to infection with malaria parasites.

Tue Sep 17 00:00:00 EDT 2013

G-CSF/anti-G-CSF antibody complexes drive the potent recovery and expansion of CD11b+Gr-1+ myeloid cells without compromising CD8+ T cell immune responses.

Journal of hematology & oncology

Rubinstein MP,Salem ML,Doedens AL,Moore CJ,Chiuzan C,Rivell GL,Cole DJ,Goldrath AW

12-0112 was used in Flow cytometry/Cell sorting to evaluate whether the biological activity of G-CSF can be improved by pre-association with anti-G-CSF monoclonal antibodies prior to injection.

Tue Oct 01 00:00:00 EDT 2013

Emulsified phosphatidylserine, simple and effective peptide carrier for induction of potent epitope-specific T cell responses.

PloS one

Ichihashi T,Satoh T,Sugimoto C,Kajino K

12-0112 was used in Flow cytometry/Cell sorting to show that phosphatidylserine is a promising novel adjuvant for T cell-inducing peptide vaccines.

Wed Sep 11 00:00:00 EDT 2013

Identification of the low density lipoprotein (LDL) receptor-related protein-1 interactome in central nervous system myelin suggests a role in the clearance of necrotic cell debris.

The Journal of biological chemistry

Fernandez-Castaneda A,Arandjelovic S,Stiles TL,Schlobach RK,Mowen KA,Gonias SL,Gaultier A

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Feb 15 00:00:00 EST 2013

Depletion of regulatory T cells in a mouse experimental glioma model through anti-CD25 treatment results in the infiltration of non-immunosuppressive myeloid cells in the brain.

Clinical & developmental immunology

Maes W,Verschuere T,Van Hoylandt A,Boon L,Van Gool S

12-0112 was used in Flow cytometry/Cell sorting to evaluate the local elimination of Tregs as a tool for augmentation of the antitumoural response.

Tue Dec 10 00:00:00 EST 2013

Rapid induction of inflammatory lipid mediators by the inflammasome in vivo.

Nature

von Moltke J,Trinidad NJ,Moayeri M,Kintzer AF,Wang SB,van Rooijen N,Brown CR,Krantz BA,Leppla SH,Gronert K,Vance RE

12-0112 was used in Flow cytometry/Cell sorting to identify novel caspase-1 protease functions in vivo using a strategy for cytosolic delivery of bacterial flagellin, a NAIP5 inflammasome ligand.

Thu Oct 04 00:00:00 EDT 2012

NF-Y is necessary for hematopoietic stem cell proliferation and survival.

Blood

Bungartz G,Land H,Scadden DT,Emerson SG

12-0112 was used in Flow cytometry/Cell sorting to show that the trimeric transcription factor NF-Y is critical for the survival of cycling, but not quiescent hematopoietic stem cells.

Thu Feb 09 00:00:00 EST 2012

Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages.

Blood

He H,Xu J,Warren CM,Duan D,Li X,Wu L,Iruela-Arispe ML

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Oct 11 00:00:00 EDT 2012

Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML.

Blood

Li Z,Huang H,Li Y,Jiang X,Chen P,Arnovitz S,Radmacher MD,Maharry K,Elkahloun A,Yang X,He C,He M,Zhang Z,Dohner K,Neilly MB,Price C,Lussier YA,Zhang Y,Larson RA,Le Beau MM,Caligiuri MA,Bullinger L,Valk PJ,Delwel R,Lowenberg B,Liu PP,Marcucci G,Bloomfield CD,Rowley JD,Chen J

12-0112 was used in Flow cytometry/Cell sorting to study the prognostic impact of the four members of the miR-181 family in patients with CA-AML.

Thu Mar 08 00:00:00 EST 2012

Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation.

Blood

Roth M,Will B,Simkin G,Narayanagari S,Barreyro L,Bartholdy B,Tamari R,Mitsiades CS,Verma A,Steidl U

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Jul 12 00:00:00 EDT 2012

IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis.

Blood

Balkhi MY,Willette-Brown J,Zhu F,Chen Z,Liu S,Guttridge DC,Karin M,Hu Y

12-0112-82 was used in Flow Cytometry to demonstrate that IKKα regulates B-lineage commitment via combined canonical and noncanonical NF-κB transcriptional activities to target Pax5 expression during hematopoiesis.

Thu Jun 07 00:00:00 EDT 2012

Dendritic cells tolerized with adenosine A₂AR agonist attenuate acute kidney injury.

The Journal of clinical investigation

Li L,Huang L,Ye H,Song SP,Bajwa A,Lee SJ,Moser EK,Jaworska K,Kinsey GR,Day YJ,Linden J,Lobo PI,Rosin DL,Okusa MD

12-0112 was used in Flow cytometry/Cell sorting to show that mice with A2AR-deficient dendritic cells are more susceptible to kidney ischemia/reperfusion injury.

Thu Nov 01 00:00:00 EDT 2012

Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity.

The Journal of clinical investigation

Johnson KD,Hsu AP,Ryu MJ,Wang J,Gao X,Boyer ME,Liu Y,Lee Y,Calvo KR,Keles S,Zhang J,Holland SM,Bresnick EH

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Mon Oct 01 00:00:00 EDT 2012

Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema.

Science translational medicine

Shan M,Yuan X,Song LZ,Roberts L,Zarinkamar N,Seryshev A,Zhang Y,Hilsenbeck S,Chang SH,Dong C,Corry DB,Kheradmand F

12-0112 was used in Flow cytometry/Cell sorting to show that cigarette smoke increases the expression of IL-17A in both CD4+ and γδ T cells from mouse lung.

Wed Jan 18 00:00:00 EST 2012

Cathepsin K deficiency reduces elastase perfusion-induced abdominal aortic aneurysms in mice.

Arteriosclerosis, thrombosis, and vascular biology

Sun J,Sukhova GK,Zhang J,Chen H,Sjöberg S,Libby P,Xia M,Xiong N,Gelb BD,Shi GP

12-0112 was used in Flow cytometry/Cell sorting to study the role of cathepsin K in abdominal aortic aneurysms.

Sun Jan 01 00:00:00 EST 2012

Identification of a microglia phenotype supportive of remyelination.

Glia

Olah M,Amor S,Brouwer N,Vinet J,Eggen B,Biber K,Boddeke HW

Wed Feb 01 00:00:00 EST 2012

FcγRI mediates serum amyloid P inhibition of fibrocyte differentiation.

Journal of leukocyte biology

Crawford JR,Pilling D,Gomer RH

12-0112 was used in Flow cytometry/Cell sorting to demonstrate that serum amyloid P uses FcγRI and FcRγ to inhibit fibrocyte differentiation.

Mon Oct 01 00:00:00 EDT 2012

Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes.

Arthritis research & therapy

Sekine C,Koyanagi A,Koyama N,Hozumi K,Chiba S,Yagita H

12-0112 was used in Flow cytometry/Cell sorting to determine the role of individual Notch receptors and ligands in osteoclastogenesis..

Mon Mar 05 00:00:00 EST 2012

Adjuvant immunotherapy of experimental autoimmune encephalomyelitis: immature myeloid cells expressing CXCL10 and CXCL16 attract CXCR3+CXCR6+ and myelin-specific T cells to the draining lymph nodes rather than the central nervous system.

Journal of immunology (Baltimore, Md. : 1950)

O'Connor RA,Li X,Blumerman S,Anderton SM,Noelle RJ,Dalton DK

12-0112 was used in Flow cytometry/Cell sorting to investigate the mechanism by which adjuvant immunotherapy with Freund's Complete Adjuvant attenuates experimental autoimmune encephalomyelitis in mice.

Thu Mar 01 00:00:00 EST 2012

Optimized protocol for the isolation of spleen-resident murine neutrophils.

Cytometry. Part A : the journal of the International Society for Analytical Cytology

Coquery CM,Loo W,Buszko M,Lannigan J,Erickson LD

12-0112 was used in Flow cytometry/Cell sorting to develop a protocol to optimally isolate spleen-resistant murine neutrophils.

Sat Sep 01 00:00:00 EDT 2012

Nocardia brasiliensis cell wall lipids modulate macrophage and dendritic responses that favor development of experimental actinomycetoma in BALB/c mice.

Infection and immunity

Trevino-Villarreal JH,Vera-Cabrera L,Valero-Guillén PL,Salinas-Carmona MC

12-0112 was used in Flow cytometry/Cell sorting to investigate the parthenogenesis of Nocardia brasiliensis infection, showing that N.brasiliensis cell wall lipids modulate macrophage and dendritic responses, leading to actinomycetoma.

Mon Oct 01 00:00:00 EDT 2012

Evaluation of in vitro macrophage differentiation during space flight.

Advances in space research : the official journal of the Committee on Space Research (COSPAR)

Ortega MT,Lu N,Chapes SK

12-0112 was used in Flow cytometry/Cell sorting to confirm that space flight can impact the in vitro development of macrophages from mouse bone marrow cells.

Tue May 15 00:00:00 EDT 2012

Changes in lamina propria dendritic cells on the oral administration of exogenous protein antigens during weaning.

Cytotechnology

Ohue R,Nakamoto M,Kitabatake N,Tani F

12-0112 was used in Flow cytometry/Cell sorting to suggest that the behavior of tolerogenic PDCA-1(+) DCs may change at weaning with the removal of the immunoprotective components of maternal milk.

Tue May 01 00:00:00 EDT 2012

Differential arabinan capping of lipoarabinomannan modulates innate immune responses and impacts T helper cell differentiation.

The Journal of biological chemistry

Mishra AK,Alves JE,Krumbach K,Nigou J,Castro AG,Geurtsen J,Eggeling L,Saraiva M,Besra GS

12-0112 was used in Flow cytometry/Cell sorting to study the implications of structural variations on TLR2 ligands for the development of T helper (Th) cell responses.

Fri Dec 28 00:00:00 EST 2012

Identification of myeloid derived suppressor cells in dogs with naturally occurring cancer.

PloS one

Goulart MR,Pluhar GE,Ohlfest JR

12-0112 was used in Flow cytometry/Cell sorting to analyse peripheral blood mononuclear cells from dogs with advanced or early stage cancer and from age-matched healthy controls.

Mon Aug 20 00:00:00 EDT 2012

Expression and function of PML-RARA in the hematopoietic progenitor cells of Ctsg-PML-RARA mice.

PloS one

Wartman LD,Welch JS,Uy GL,Klco JM,Lamprecht T,Varghese N,Nagarajan R,Ley TJ

12-0112 was used in Flow cytometry/Cell sorting to study PML-RARA expression to better understand its mechanism of contribution to APL.

Tue Jun 11 00:00:00 EDT 2013

Dietary n-3 polyunsaturated fatty acids (PUFA) decrease obesity-associated Th17 cell-mediated inflammation during colitis.

PloS one

Monk JM,Hou TY,Turk HF,Weeks B,Wu C,McMurray DN,Chapkin RS

12-0112 was used in Flow cytometry/Cell sorting to monitor changes in immune cell subsets and inflammatory biomarker expression in a mouse model of concurrent obesity and colitis.

Thu Jun 20 00:00:00 EDT 2013

Impact of enzymatic tissue disintegration on the level of surface molecule expression and immune cell function.

European journal of microbiology & immunology

Autengruber A,Gereke M,Hansen G,Hennig C,Bruder D

12-0112 was used in Flow cytometry/Cell sorting to indicate that enzymatic tissue disintegration can have profound effects on the expression of a variety of cell-surface molecules.

Fri Jun 01 00:00:00 EDT 2012

Genomic expression analyses reveal lysosomal, innate immunity proteins, as disease correlates in murine models of a lysosomal storage disorder.

PloS one

Alam MS,Getz M,Safeukui I,Yi S,Tamez P,Shin J,Velázquez P,Haldar K

12-0112 was used in Flow cytometry/Cell sorting to identify Niemann-Pick Type C disease severity correlates, showing that expression of lysosomal, innate immunity proteins correlate with severity.

Mon Apr 01 00:00:00 EDT 2013

Anti-thymocyte globulin (ATG) differentially depletes naïve and memory T cells and permits memory-type regulatory T cells in nonobese diabetic mice.

BMC immunology

Xia CQ,Chernatynskaya AV,Wasserfall CH,Wan S,Looney BM,Eisenbeis S,Williams J,Clare-Salzler MJ,Atkinson MA

12-0112 was used in Flow cytometry/Cell sorting to assess how murine ATG therapy affects T cell subsets in NOD mice, and its influence on antigen-specific immune responses.

Fri Dec 14 00:00:00 EST 2012

Induction of histiocytic sarcoma in mouse skeletal muscle.

PloS one

Liu J,Hettmer S,Milsom MD,Hofmann I,Hua F,Miller C,Bronson RT,Wagers AJ

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Thu Feb 07 00:00:00 EST 2013

Cell-selective inhibition of NF-κB signaling improves therapeutic index in a melanoma chemotherapy model.

Cancer discovery

Enzler T,Sano Y,Choo MK,Cottam HB,Karin M,Tsao H,Park JM

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Nov 01 00:00:00 EDT 2011

Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation.

Cell host & microbe

Jensen KD,Wang Y,Wojno ED,Shastri AJ,Hu K,Cornel L,Boedec E,Ong YC,Chien YH,Hunter CA,Boothroyd JC,Saeij JP

12-0112 was used in Flow cytometry/Cell sorting to investigate how Toxoplasma-secreted effectors work to achieve chronic infection.

Thu Jun 16 00:00:00 EDT 2011

Mouse Ly49G2+ NK cells dominate early responses during both immune reconstitution and activation independently of MHC.

Blood

Barao I,Alvarez M,Ames E,Orr MT,Stefanski HE,Blazar BR,Lanier LL,Anderson SK,Redelman D,Murphy WJ

12-0112 was used in Flow cytometry/Cell sorting to show that during reconstitution after HSCT and various activation stimuli, preferential expansion of the Ly49G2 receptor on NK cells occurs independently of MHC haplotype.

Thu Jun 30 00:00:00 EDT 2011

PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice.

The Journal of clinical investigation

Welch JS,Yuan W,Ley TJ

12-0112 was used in Flow cytometry/Cell sorting to study a platform for more accurately dissecting the early events in acute promyelocytic leukemia pathogenesis.

Fri Apr 01 00:00:00 EDT 2011

Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice.

The Journal of clinical investigation

Maniati E,Bossard M,Cook N,Candido JB,Emami-Shahri N,Nedospasov SA,Balkwill FR,Tuveson DA,Hagemann T

12-0112 was used in Flow cytometry/Cell sorting to reveal a novel interaction between oncogenic inflammation and the NF-κB pathway.

Thu Dec 01 00:00:00 EST 2011

Morphological plasticity promotes resistance to phagocyte killing of uropathogenic Escherichia coli.

Microbes and infection

Horvath DJ,Li B,Casper T,Partida-Sanchez S,Hunstad DA,Hultgren SJ,Justice SS

12-0112 was used in Flow cytometry/Cell sorting to demonstrate that SulA-mediated filamentation in UPEC provides a selective advantage in evading phagocytic killing, and represents a distinct class of mechanism for subverting host immunity.

Sun May 01 00:00:00 EDT 2011

Arginase-2 mediates diabetic renal injury.

Diabetes

Morris SM,Gao T,Cooper TK,Kepka-Lenhart D,Awad AS

12-0112 was used in Flow cytometry/Cell sorting to determine whether renal arginase activity or expression is increased in diabetes and whether arginase plays a role in development of diabetic nephropathy (DN), showing that arginase-2 mediates diabetic renal injury.

Tue Nov 01 00:00:00 EDT 2011

Elevated epidermal ornithine decarboxylase activity suppresses contact hypersensitivity.

The Journal of investigative dermatology

Keough MP,Hayes CS,DeFeo K,Gilmour SK

12-0112 was used in Flow cytometry/Cell sorting to suggest that the immunosuppression promoted by increased epidermal ODC is mediated by a reduction in cytokine levels, which suppresses DC migration and reduces immune cell infiltration to the site of hapten application.

Sat Jan 01 00:00:00 EST 2011

UV exposure boosts transcutaneous immunization and improves tumor immunity: cytotoxic T-cell priming through the skin.

The Journal of investigative dermatology

Stein P,Rechtsteiner G,Warger T,Bopp T,Fuhr T,Prüfer S,Probst HC,Stassen M,Langguth P,Schild H,Radsak MP

12-0112 was used in Flow Cytometry to explore the effects of ultraviolet irradiation on imiquimod-based transcutaneous immunisation.

Sat Jan 01 00:00:00 EST 2011

A tritherapy combination of a fusion protein vaccine with immune-modulating doses of sequential chemotherapies in an optimized regimen completely eradicates large tumors in mice.

International journal of cancer

Song X,Guo W,Cui J,Qian X,Yi L,Chang M,Cai Q,Zhao Q

12-0112 was used in Flow cytometry/Cell sorting to study the immune-modulating doses of sequential chemoimmunotherapeutic strategy targeting not only the tumour but also its microenvironment.

Tue Mar 01 00:00:00 EST 2011

Effects of Pre-conditioning Dose on the Immune Kinetics and Cytokine Production in the Leukocytes Infiltrating GVHD Tissues after MHC-matched Transplantation.

Immune network

Choi JH,Yoon H,Min CK,Choi EY

12-0112 was used in Flow cytometry/Cell sorting to analyse chimerism formation and immune kinetics of leukocytes during graft-versus-host disease.

Tue Feb 01 00:00:00 EST 2011

Hydrodynamic delivery of human IL-15 cDNA increases murine natural killer cell recovery after syngeneic bone marrow transplantation.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

Barao I,Alvarez M,Redelman D,Weiss JM,Ortaldo JR,Wiltrout RH,Murphy WJ

12-0112 was used in Flow cytometry/Cell sorting to highlight cytokine gene transfer-based methods as a potential platform for natural killer cell recovery after bone marrow transplantation in mice.

Thu Dec 01 00:00:00 EST 2011

Exacerbated experimental autoimmune encephalomyelitis in mast-cell-deficient Kit W-sh/W-sh mice.

Laboratory investigation; a journal of technical methods and pathology

Piconese S,Costanza M,Musio S,Tripodo C,Poliani PL,Gri G,Burocchi A,Pittoni P,Gorzanelli A,Colombo MP,Pedotti R

12-0112 was used in Flow cytometry/Cell sorting to investigate the potential detrimental role of mast cells in experimental autoimmune encephalomyelitis.

Fri Apr 01 00:00:00 EDT 2011

SIRPα/CD172a regulates eosinophil homeostasis.

Journal of immunology (Baltimore, Md. : 1950)

Verjan Garcia N,Umemoto E,Saito Y,Yamasaki M,Hata E,Matozaki T,Murakami M,Jung YJ,Woo SY,Seoh JY,Jang MH,Aozasa K,Miyasaka M

12-0112 was used in Flow cytometry/Cell sorting to study the expression of an inhibitory receptor signal regulatory protein and CD36 in intestinal eosinophils.

Thu Sep 01 00:00:00 EDT 2011

Genetic variation determines mast cell functions in experimental asthma.

Journal of immunology (Baltimore, Md. : 1950)

Becker M,Reuter S,Friedrich P,Doener F,Michel A,Bopp T,Klein M,Schmitt E,Schild H,Radsak MP,Echtenacher B,Taube C,Stassen M

12-0112 was used in Flow cytometry/Cell sorting to investigate the role of mast cells in allergic asthma.

Wed Jun 15 00:00:00 EDT 2011

Monocyte/macrophage chemokine receptor CCR2 mediates diabetic renal injury.

American journal of physiology. Renal physiology

Awad AS,Kinsey GR,Khutsishvili K,Gao T,Bolton WK,Okusa MD

12-0112 was used in Flow cytometry/Cell sorting to study the mediation of diabetic renal injury by monocyte/macrophage chemokine receptor CCR2.

Thu Dec 01 00:00:00 EST 2011

High phosphate diet reduces atherosclerosis formation in apolipoprotein E-deficient mice.

Journal of clinical biochemistry and nutrition

Shiota A,Taketani Y,Maekawa Y,Yasutomo K,Sata M,Sakai T,Mizuno R,Isshiki M,Yamamoto H,Takeda E

12-0112 was used in Flow cytometry/Cell sorting to investigate how excess phosphate intake decreases atherosclerosis formation by changing the profile of peripheral monocytes or inducing apoptosis of macrophages in apolipoprotein E-deficient mice.

Thu Sep 01 00:00:00 EDT 2011

PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection.

PloS one

Hemmers S,Teijaro JR,Arandjelovic S,Mowen KA

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Tue Nov 15 00:00:00 EST 2011

Protein kinase D2 is an essential regulator of murine myoblast differentiation.

PloS one

Kleger A,Loebnitz C,Pusapati GV,Armacki M,Müller M,Tümpel S,Illing A,Hartmann D,Brunner C,Liebau S,Rudolph KL,Adler G,Seufferlein T

12-0112 was used in Flow cytometry/Cell sorting to identify protein kinase D2 as a major mediator of muscle cell differentiation in vitro and a potential novel target for the modulation of muscle regeneration.

Thu Jan 27 00:00:00 EST 2011

Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths.

Immunity

Ohnmacht C,Schwartz C,Panzer M,Schiedewitz I,Naumann R,Voehringer D

12-0112 was used in Flow cytometry/Cell sorting to demonstrate that basophils play an important role for protective immunity against helminths and orchestrate chronic allergic inflammation.

Fri Sep 24 00:00:00 EDT 2010

Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2.

Blood

Huber S,Hoffmann R,Muskens F,Voehringer D

12-0112 was used in Flow cytometry/Cell sorting to study how IL-4 induced the expression of PD-L2 on CAM, and LPS increased the expression of PD-L1 on alternatively activated macrophages.

Thu Oct 28 00:00:00 EDT 2010

IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury.

The Journal of clinical investigation

Li L,Huang L,Vergis AL,Ye H,Bajwa A,Narayan V,Strieter RM,Rosin DL,Okusa MD

12-0112 was used in Flow cytometry/Cell sorting to study how IFN-gamma mediated neutrophil migration is mediated by upstream secretion of IL-17 in mouse kidney ischemia-reperfusion injury.

Fri Jan 01 00:00:00 EST 2010

Tumor masses support naive T cell infiltration, activation, and differentiation into effectors.

The Journal of experimental medicine

Thompson ED,Enriquez HL,Fu YX,Engelhard VH

12-0112 was used in Flow cytometry/Cell sorting to study the ways in which tumour masses support naive T cell functions.

Mon Aug 02 00:00:00 EDT 2010

Prophylactic administration of bacterially derived immunomodulators improves the outcome of influenza virus infection in a murine model.

Journal of virology

Norton EB,Clements JD,Voss TG,Cárdenas-Freytag L

12-0112 was used in Flow cytometry/Cell sorting to investigate the effect of prophylactic immunomodulation on the outcome of viral infection.

Mon Mar 01 00:00:00 EST 2010

Fine-scale staging of T cell lineage commitment in adult mouse thymus.

Journal of immunology (Baltimore, Md. : 1950)

Yui MA,Feng N,Rothenberg EV

12-0112 was used in Flow cytometry/Cell sorting to determine the gene regulatory changes that accompany commitment in adult wild-type double-negative adult thymocytes.

Thu Jul 01 00:00:00 EDT 2010

Ability of IDO to attenuate liver injury in alpha-galactosylceramide-induced hepatitis model.

Journal of immunology (Baltimore, Md. : 1950)

Ito H,Hoshi M,Ohtaki H,Taguchi A,Ando K,Ishikawa T,Osawa Y,Hara A,Moriwaki H,Saito K,Seishima M

12-0112 was used in Flow cytometry/Cell sorting to study the immunological effects of IDO in α-galactosylceramide (α-GalCer)-induced hepatitis.

Fri Oct 15 00:00:00 EDT 2010

Dysregulated macrophage-inflammatory protein-2 expression drives illness in bacterial superinfection of influenza.

Journal of immunology (Baltimore, Md. : 1950)

Zavitz CC,Bauer CM,Gaschler GJ,Fraser KM,Strieter RM,Hogaboam CM,Stampfli MR

12-0112 was used in Flow cytometry/Cell sorting to suggest that pulmonary inflammation is the key threat during bacterial superinfection of influenza.

Mon Feb 15 00:00:00 EST 2010

BTN1A1, the mammary gland butyrophilin, and BTN2A2 are both inhibitors of T cell activation.

Journal of immunology (Baltimore, Md. : 1950)

Smith IA,Knezevic BR,Ammann JU,Rhodes DA,Aw D,Palmer DB,Mather IH,Trowsdale J

12-0112 was used in Flow cytometry/Cell sorting to confirm a coinhibitory role for mouse BTN1A1.

Thu Apr 01 00:00:00 EDT 2010

Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury.

Journal of immunology (Baltimore, Md. : 1950)

Su X,Matthay MA,Malik AB

12-0112 was used in Flow cytometry/Cell sorting to identify a novel strategy for the treatment of sepsis-induced acute lung injury.

Fri Jan 01 00:00:00 EST 2010

FLT-3 expression and function on microglia in multiple sclerosis.

Experimental and molecular pathology

DeBoy CA,Rus H,Tegla C,Cudrici C,Jones MV,Pardo CA,Small D,Whartenby KA,Calabresi PA

12-0112 was used in Flow cytometry/Cell sorting to study the expression and function of FLT-3 in microglia in multiple sclerosis, suggesting that FLT-3 could be a therapeutic target to mitigate CNS inflammation.

Fri Oct 01 00:00:00 EDT 2010

Improved serum-free culture conditions for spleen-derived murine fibrocytes.

Journal of immunological methods

Crawford JR,Pilling D,Gomer RH

12-0112 was used in Flow cytometry/Cell sorting to develop an optimised method of differentiating spleen-derived murine fibrocytes over five days.

Wed Dec 15 00:00:00 EST 2010

Improved serum-free culture conditions for spleen-derived murine fibrocytes.

Journal of immunological methods

Crawford JR,Pilling D,Gomer RH

12-0112 was used in Flow cytometry/Cell sorting to develop an optimised method of differentiating spleen-derived murine fibrocytes over five days.

Wed Dec 15 00:00:00 EST 2010

Intermediate-term hematopoietic stem cells with extended but time-limited reconstitution potential.

Cell stem cell

Benveniste P,Frelin C,Janmohamed S,Barbara M,Herrington R,Hyam D,Iscove NN

12-0112 was used in Flow cytometry/Cell sorting to investigate the presence of "intermediate-term" multipotent hematopoietic stem cells, revealing that these cells are able to sustain clones of differentiating cells for only 4-6 weeks.

Fri Jan 08 00:00:00 EST 2010

CBFbeta is critical for AML1-ETO and TEL-AML1 activity.

Blood

Roudaia L,Cheney MD,Manuylova E,Chen W,Morrow M,Park S,Lee CT,Kaur P,Williams O,Bushweller JH,Speck NA

12-0112 was used in Flow cytometry/Cell sorting to validate the AML1-ETO and TEL-AML1 chimeric protein Runt domain/CBFbeta interaction as a therapeutic target in core binding factor leukemias.

Thu Mar 26 00:00:00 EDT 2009

Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells.

Cell stem cell

Le Grand F,Jones AE,Seale V,Scimè A,Rudnicki MA

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Jun 05 00:00:00 EDT 2009

Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury.

Journal of the American Society of Nephrology : JASN

Kinsey GR,Sharma R,Huang L,Li L,Vergis AL,Ye H,Ju ST,Okusa MD

12-0112 was used in Flow cytometry/Cell sorting to investigate whether the anti-inflammatory effects of CD4(+)CD25(+)FoxP3(+) Tregs protect against renal IRI.

Sat Aug 01 00:00:00 EDT 2009

STAT6-mediated suppression of erythropoiesis in an experimental model of malarial anemia.

Haematologica

Thawani N,Tam M,Stevenson MM

12-0112 was used in Flow cytometry/Cell sorting to investigate the role of STAT6-mediated responses in erythropoietic suppression during acute malaria infection in mice.

Sun Feb 01 00:00:00 EST 2009

The cellular niche of Listeria monocytogenes infection changes rapidly in the spleen.

European journal of immunology

Aoshi T,Carrero JA,Konjufca V,Koide Y,Unanue ER,Miller MJ

12-0112 was used in Immunohistochemistry to illustrate the changeable nature of the cellular niche of Listeria monocytogenes.

Sun Feb 01 00:00:00 EST 2009

A possible contribution of retinoids to regulation of fetal B lymphopoiesis.

European journal of immunology

Chen X,Welner RS,Kincade PW

12-0112 was used in Flow cytometry/Cell sorting to determine that retinoids may partially account for rapid differentiation in foetal life, but not for all unique features of foetal progenitors.

Tue Sep 01 00:00:00 EDT 2009

Combination of all-trans retinoic acid and a human papillomavirus therapeutic vaccine suppresses the number and function of immature myeloid cells and enhances antitumor immunity.

Cancer science

Song X,Ye D,Liu B,Cui J,Zhao X,Yi L,Liang J,Song J,Zhang Z,Zhao Q

12-0112-82 was used in Flow Cytometry to suggest potential clinical benefits for the combined use of ATRA and HPV therapeutic vaccines.

Sun Feb 01 00:00:00 EST 2009

Nylon wool purification alters the activation of T cells.

Molecular immunology

Wohler JE,Barnum SR

12-0112 was used in Flow cytometry/Cell sorting to examine the effects of nylon wool purification on T cell proliferation, activation marker expression and cytokine production.

Sun Feb 01 00:00:00 EST 2009

Shifts in bone marrow cell phenotypes caused by spaceflight.

Journal of applied physiology (Bethesda, Md. : 1985)

Ortega MT,Pecaut MJ,Gridley DS,Stodieck LS,Ferguson V,Chapes SK

12-0112 was used in Flow cytometry/Cell sorting to determine how spaceflight affects differentiation of cells in the granulocytic lineage in mice.

Sun Feb 01 00:00:00 EST 2009

IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response.

Blood

Rubinstein MP,Lind NA,Purton JF,Filippou P,Best JA,McGhee PA,Surh CD,Goldrath AW

12-0112 was used in Flow cytometry/Cell sorting to study IL-7 and IL-15 regulation of CD8+ T-cell subsets during contraction of the immune response.

Sat Nov 01 00:00:00 EDT 2008

Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS.

Glia

de Haas AH,Boddeke HW,Biber K

12-0112 was used in Flow cytometry/Cell sorting to evaluate the existence of distinct microglia phenotypes in various regions of the healthy, adult mouse central nervous system.

Sun Jun 01 00:00:00 EDT 2008

Characterization of fibroblasts responsible for cartilage destruction in arthritis.

Cytometry. Part A : the journal of the International Society for Analytical Cytology

Treese C,Mittag A,Lange F,Tarnok A,Loesche A,Emmrich F,Lehmann J,Sack U

12-0112 was used in Flow cytometry/Cell sorting to show that LS48 is an excellent tool to gain a deeper understanding of synovial fibroblasts in rheumatoid arthritis.

Tue Apr 01 00:00:00 EDT 2008

Recruitment and in situ renewal regulate rapid accumulation of CD11c+ cells in the lung following intranasal superantigen challenge.

International archives of allergy and immunology

Muralimohan G,Rossi RJ,Vella AT

12-0112 was used in Flow cytometry/Cell sorting to investigate how staphylococcal enterotoxins regulate innate immune cells, showing that it leads to rapid accumulation of CD11c+ cells in the lung following superantigen challenge.

Tue Sep 09 00:00:00 EDT 2008

Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis.

The Journal of biological chemistry

Chen Y,Wang X,Di L,Fu G,Chen Y,Bai L,Liu J,Feng X,McDonald JM,Michalek S,He Y,Yu M,Fu YX,Wen R,Wu H,Wang D

Published figure using CD11b monoclonal antibody (Product # 12-0112-82) in Flow Cytometry

Fri Oct 24 00:00:00 EDT 2008

Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 "cherubism" mice.

Cell

Ueki Y,Lin CY,Senoo M,Ebihara T,Agata N,Onji M,Saheki Y,Kawai T,Mukherjee PM,Reichenberger E,Olsen BR

12-0112 was used in Flow cytometry/Cell sorting to demonstrate that Sh3bp2 "cherubism'' mice exhibit trabecular bone loss, TNF-α-dependent systemic inflammation, and cortical bone erosion.

Fri Jan 12 00:00:00 EST 2007

Presenilins regulate alphabeta T cell development by modulating TCR signaling.

The Journal of experimental medicine

Laky K,Fowlkes BJ

12-0112 was used in Flow cytometry/Cell sorting to suggest a model in which PS-dependent Notch signalling influences positive selection and the development of alphabeta T cells by modifying TCR signal transduction.

Mon Sep 03 00:00:00 EDT 2007

Chronic interleukin-1beta expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Shaftel SS,Carlson TJ,Olschowka JA,Kyrkanides S,Matousek SB,O'Banion MK

12-0112 was used in Flow cytometry/Cell sorting to delineate the effects of sustained unilateral hippocampal overexpression of IL-1beta.

Wed Aug 29 00:00:00 EDT 2007

Immature hematopoietic cells display selective requirements for adhesion- and degranulation-promoting adaptor protein in development and homeostatsis.

European journal of immunology

Dluzniewska J,Zou L,Harmon IR,Ellingson MT,Peterson EJ

12-0112-82 was used in Flow Cytometry to highlight the dynamic regulation of ADAP during T cell maturation and document expression patterns that suggest a possible role for ADAP in development of non-T hematopoietic lineages.

Thu Nov 01 00:00:00 EDT 2007

Macrophage-mediated but gamma interferon-independent innate immune responses control the primary wave of Plasmodium yoelii parasitemia.

Infection and immunity

Couper KN,Blount DG,Hafalla JC,van Rooijen N,de Souza JB,Riley EM

12-0112 was used in Flow cytometry/Cell sorting to discern the factors that control the primary wave of plasmodium yoelii parasitaemia.

Sat Dec 01 00:00:00 EST 2007

Tumor growth impedes natural-killer-cell maturation in the bone marrow.

Blood

Richards JO,Chang X,Blaser BW,Caligiuri MA,Zheng P,Liu Y

12-0112 was used in Flow cytometry/Cell sorting to demonstrate that tumour growth can impede functional maturation of NK cells, most likely by interrupting the requisite IL-15 signalling pathway.

Sat Jul 01 00:00:00 EDT 2006

B-1 B lymphocytes require Blimp-1 for immunoglobulin secretion.

The Journal of experimental medicine

Savitsky D,Calame K

12-0112 was used in Flow cytometry/Cell sorting to show that Blimp-1 is not necessary for the formation or self-renewal of B-1 B cells but that Blimp-1 is required for normal immunoglobulin (Ig) secretion by B-1 cells.

Mon Oct 02 00:00:00 EDT 2006

Induction of robust immune responses against human immunodeficiency virus is supported by the inherent tropism of adeno-associated virus type 5 for dendritic cells.

Journal of virology

Xin KQ,Mizukami H,Urabe M,Toda Y,Shinoda K,Yoshida A,Oomura K,Kojima Y,Ichino M,Klinman D,Ozawa K,Okuda K

12-0112 was used in Flow cytometry/Cell sorting to investigate the ability of different adeno-associated virus vectors expressing the human immunodeficiency virus to induce a robust immune response, and the factors which affect this.

Fri Dec 01 00:00:00 EST 2006

Neutrophil signaling pathways activated by bacterial DNA stimulation.

Journal of immunology (Baltimore, Md. : 1950)

Alvarez ME,Fuxman Bass JI,Geffner JR,Fernández Calotti PX,Costas M,Coso OA,Gamberale R,Vermeulen ME,Salamone G,Martinez D,Tanos T,Trevani AS

12-0112-82 was used in flow cytometry to determine that bacterial DNA stimulated CD11b up-regulation in TLR9(-/-) but not in MyD88(-/-) mouse neutrophils, supporting that bacterial DNA induces neutrophil activation through a TLR9-independent and MyD88-dependent pathway.

Fri Sep 15 00:00:00 EDT 2006

Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization.

The Journal of experimental medicine

Setoguchi R,Hori S,Takahashi T,Sakaguchi S

12-0112 was used in Flow cytometry/Cell sorting to evidence the homeostatic maintenance of Foxp3-expressing CD25+CD4+ regulatory T cells by interleukin (IL)-2, the neutralisation of which, produces a wide spectrum of T cell-mediated autoimmune diseases.

Mon Mar 07 00:00:00 EST 2005

B1b lymphocytes confer T cell-independent long-lasting immunity.

Immunity

Alugupalli KR,Leong JM,Woodland RT,Muramatsu M,Honjo T,Gerstein RM

12-0112 was used in Flow cytometry/Cell sorting to demonstrate that B1b lymphocytes provide long-lasting T cell-independent IgM memory and a successful resolution of Borrelia hermsiibacteremia in mice.

Wed Sep 01 00:00:00 EDT 2004

The integrin alphaMbeta2 anchors hematopoietic progenitors in the bone marrow during enforced mobilization.

Blood

Hidalgo A,Peired AJ,Weiss LA,Katayama Y,Frenette PS

12-0112 was used in Flow cytometry/Cell sorting to investigate the mechanisms involved in mobilisation of hematopoietic progenitor cells by fucoidan.

Sun Aug 15 00:00:00 EDT 2004

In vivo survival and homeostatic proliferation of natural killer cells.

The Journal of experimental medicine

Prlic M,Blazar BR,Farrar MA,Jameson SC

12-0112 was used in Flow cytometry/Cell sorting to show that mouse NK cells undergo homeostatic proliferation when transferred into NK-deficient Rag-/- gammaC-/- hosts.

Mon Apr 21 00:00:00 EDT 2003

Bioinformatics

Protein Aliases: CD11 antigen-like family member B; CD11B (p170); cell surface glycoprotein MAC-1 alpha subunit; cell surface glycoprotein MAC-1 subunit alpha; complement component receptor 3 alpha-a; complement receptor type 3; CR-3 alpha chain; integrin alpha-M; leukocyte adhesion receptor MO1; Mac-1 alpha; Mac-1 alpha (Mac1A); macrophage antigen alpha; MGC117044

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Gene Aliases: Cd11b; CD11b/CD18; CR3; CR3A; F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1

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Entrez Gene ID: (Mouse) 16409

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Function(s)

opsonin binding glycoprotein binding heparin binding heparan sulfate proteoglycan binding metal ion binding protein heterodimerization activity integrin

Process(es)

leukocyte migration involved in inflammatory response cell adhesion leukocyte cell-cell adhesion integrin-mediated signaling pathway microglia development single organismal cell-cell adhesion neutrophil chemotaxis cellular extravasation activated T cell proliferation

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CD11b Monoclonal Antibody (M1/70), PE, eBioscience™

CD11b Antibody (12-0112-82) in Flow

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12-0112-82

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