Invitrogen

CD127 Monoclonal Antibody (A7R34), FITC, eBioscience™

FIGURE: 1 / 20

CD127 Antibody (11-1271-82) in Flow

C57BL/6 mouse splenocytes were stained with CD3e Monoclonal Antibody, APC-eFluor 780 (Product # 47-0031-82) and 0.5 µg of Rat IgG2a kappa Isotype Control, FITC (Product # 11-4321-85) (left) or 0.5 µg of CD127 Monoclonal Antibody, FITC (right). Cells in the lymphocyte gate were used for analysis.

CD127 Antibody in Immunohistochemistry (IHC)

Product Image Gallery

Product Details

11-1271-82

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Flow Cytometry (Flow)

1 µg/test

View 44 publications 44 publications

Product Specifications

Species Reactivity

Mouse

Published species

Mouse

Host/Isotype

Rat / IgG2a, kappa

Recommended Isotype Control

Rat IgG2a kappa Isotype Control (eBR2a), FITC, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

A7R34

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_465195

Product Specific Information

Description: The A7R34 monoclonal antibody reacts with mouse CD127, the high affinity alpha subunit of the mouse IL-7 receptor. IL-7 receptor alpha chain is expressed by immature B cells in the bone marrow, double-negative (CD4-CD8-), single-positive (CD4+ and CD8+), but not double-positive (CD4+CD8+) thymocytes. In the periphery, mature T cells express CD127 at low level. A7R34 inhibits binding of IL-7 to its receptor and has been used in in vivo and in vitro studies to elucidate the role of IL-7 in T and B cell development and activation. Binding of A7R34 blocks the binding of SB/199, another antibody which recognizes mouse CD127.

Applications Reported: The A7R34 antibody has been reported for use in flow cytometric analysis.

Applications Tested: The A7R34 antibody has been tested by flow cytometric analysis of mouse thymocytes and splenocytes. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD127 (Interleukin-7, IL-7) is a glycoprotein involved in the regulation of lymphopoiesis. The response of cells to CD127 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer. CD127 consists of an alpha chain and a gamma chain. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. CD127 promotes the proliferation of precursor B cells, thymocytes, T cell progenitors, and mature CD4+ and CD8+ T cells. The biological effects of IL7 are mediated by the binding of IL7 to the specific cell surface receptor. Diseases associated with CD127 dysfunction include severe combined immunodeficiency and T cell negative/B cell negative/NK positive severe combined immunodeficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

Role of Nox4 in Mitigating Inflammation and Fibrosis in Dextran Sulfate Sodium-Induced Colitis.

Cellular and molecular gastroenterology and hepatology

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Published figure using CD127 monoclonal antibody (Product # 11-1271-82) in Immunohistochemistry

Tue Aug 22 00:00:00 EDT 2023

Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J

Published figure using CD127 monoclonal antibody (Product # 11-1271-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

MicroRNA‑21‑5p protects melanocytes via targeting STAT3 and modulating Treg/Teff balance to alleviate vitiligo.

Molecular medicine reports

Huo J,Liu T,Li F,Song X,Hou X

Published figure using CD127 monoclonal antibody (Product # 11-1271-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2021

PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8⁺ T cells at the expense of central memory.

Cell reports

Cannons JL,Villarino AV,Kapnick SM,Preite S,Shih HY,Gomez-Rodriguez J,Kaul Z,Shibata H,Reilley JM,Huang B,Handon R,McBain IT,Gossa S,Wu T,Su HC,McGavern DB,O'Shea JJ,McGuire PJ,Uzel G,Schwartzberg PL

Published figure using CD127 monoclonal antibody (Product # 11-1271-82) in Flow Cytometry

Tue Oct 12 00:00:00 EDT 2021

Hedgehog interacting protein-expressing lung fibroblasts suppress lymphocytic inflammation in mice.

JCI insight

Yun JH,Lee C,Liu T,Liu S,Kim EY,Xu S,Curtis JL,Pinello L,Bowler RP,Silverman EK,Hersh CP,Zhou X

Published figure using CD127 monoclonal antibody (Product # 11-1271-82) in Flow Cytometry

Wed Sep 08 00:00:00 EDT 2021

Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development.

Developmental cell

Dege C,Fegan KH,Creamer JP,Berrien-Elliott MM,Luff SA,Kim D,Wagner JA,Kingsley PD,McGrath KE,Fehniger TA,Palis J,Sturgeon CM

11-1271 was used in Flow cytometry/Cell sorting to identify an extra-embryonic origin of potently cytotoxic NK cells, suggesting that ontogenic origin is a relevant factor in designing hPSC-derived adoptive immunotherapies.

Mon Apr 20 00:00:00 EDT 2020

RIPK3 and Caspase-1/11 Are Necessary for Optimal Antigen-Specific CD8 T Cell Response Elicited by Genetically Modified Listeria monocytogenes.

Frontiers in immunology

Rana A,de Almeida FC,Paico Montero HA,Gonzales Carazas MM,Bortoluci KR,Sad S,Amarante-Mendes GP

Published figure using CD127 monoclonal antibody (Product # 11-1271-82) in Flow Cytometry

Fri Mar 26 00:00:00 EDT 2021

Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.

Nature

Wilkinson AC,Ishida R,Kikuchi M,Sudo K,Morita M,Crisostomo RV,Yamamoto R,Loh KM,Nakamura Y,Watanabe M,Nakauchi H,Yamazaki S

11-1271 was used in Flow cytometry/Cell sorting to identify polyvinyl alcohol as a functionally superior replacement for serum albumin that is compatible with good manufacturing practice.

Mon Jul 01 00:00:00 EDT 2019

An Id2^RFP-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials.

Immunity

Xu W,Cherrier DE,Chea S,Vosshenrich C,Serafini N,Petit M,Liu P,Golub R,Di Santo JP

Published figure using CD127 monoclonal antibody (Product # 11-1271-82) in Flow Cytometry

Tue Apr 16 00:00:00 EDT 2019

Activation of naïve CD4⁺ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4⁺ T cells.

Nature immunology

Twohig JP,Cardus Figueras A,Andrews R,Wiede F,Cossins BC,Derrac Soria A,Lewis MJ,Townsend MJ,Millrine D,Li J,Hill DG,Uceda Fernandez J,Liu X,Szomolay B,Pepper CJ,Taylor PR,Pitzalis C,Tiganis T,Williams NM,Jones GW,Jones SA

Published figure using CD127 monoclonal antibody (Product # 11-1271-82) in Flow Cytometry

Mon Apr 01 00:00:00 EDT 2019

Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer.

The Journal of clinical investigation

Soukup AA,Zheng Y,Mehta C,Wu J,Liu P,Cao M,Hofmann I,Zhou Y,Zhang J,Johnson KD,Choi K,Keles S,Bresnick EH

11-1271 was used in Flow cytometry/Cell sorting to study the mechanisms underlying how GATA2 enhancer disease mutations impact hematopoiesis and pathology.

Fri Mar 01 00:00:00 EST 2019

Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis.

Haematologica

Zhang Z,Huang Z,Ong B,Sahu C,Zeng H,Ruan HB

Published figure using CD127 monoclonal antibody (Product # 11-1271-82) in Flow Cytometry

Sun Sep 01 00:00:00 EDT 2019

Single-Cell Profiling Defines Transcriptomic Signatures Specific to Tumor-Reactive versus Virus-Responsive CD4⁺ T Cells.

Cell reports

Magen A,Nie J,Ciucci T,Tamoutounour S,Zhao Y,Mehta M,Tran B,McGavern DB,Hannenhalli S,Bosselut R

Published figure using CD127 monoclonal antibody (Product # 11-1271-82) in Flow Cytometry

Tue Dec 03 00:00:00 EST 2019

Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells.

JCI insight

Huang A,Shinde PV,Huang J,Senff T,Xu HC,Margotta C,Häussinger D,Willnow TE,Zhang J,Pandyra AA,Timm J,Weggen S,Lang KS,Lang PA

11-1271 was used in Flow cytometry/Cell sorting to show that progranulin (PGRN) can reduce NK cell cytotoxicity through reduction of NK cell expansion, granzyme B transcription, and NK cell-mediated lysis of target cells.

Thu Sep 05 00:00:00 EDT 2019

Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation.

Immunity

Emgård J,Kammoun H,García-Cassani B,Chesné J,Parigi SM,Jacob JM,Cheng HW,Evren E,Das S,Czarnewski P,Sleiers N,Melo-Gonzalez F,Kvedaraite E,Svensson M,Scandella E,Hepworth MR,Huber S,Ludewig B,Peduto L,Villablanca EJ,Veiga-Fernandes H,Pereira JP,Flavell RA,Willinger T

11-1271 was used in Flow cytometry/Cell sorting to show that GPR183 promotes lymphoid organ development and indicate that oxysterol-GPR183-dependent positioning within tissues controls ILC3 activity and intestinal homeostasis.

Tue Jan 16 00:00:00 EST 2018

E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.

Immunity

Li Q,Li D,Zhang X,Wan Q,Zhang W,Zheng M,Zou L,Elly C,Lee JH,Liu YC

11-1271 was used in Flow Cytometry to indicate that the VHL-HIF-glycolysis axis is essential for the late-stage maturation and function of ILC2s via targeting IL-33-ST2 pathway.

Tue Feb 20 00:00:00 EST 2018

Human leukemia mutations corrupt but do not abrogate GATA-2 function.

Proceedings of the National Academy of Sciences of the United States of America

Katsumura KR,Mehta C,Hewitt KJ,Soukup AA,Fraga de Andrade I,Ranheim EA,Johnson KD,Bresnick EH

11-1271 was used in Flow cytometry/Cell sorting to determine whether distinct mutations differentially impact GATA 2 mechanisms.

Tue Oct 23 00:00:00 EDT 2018

Inactivation of mTORC1 Signaling in Osterix-Expressing Cells Impairs B-cell Differentiation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Wang Y,Xiao M,Tao C,Chen J,Wang Z,Yang J,Chen Z,Zou Z,Liu A,Cai D,Jiang Y,Ding C,Li M,Bai X

Published figure using CD127 monoclonal antibody (Product # 11-1271-82) in Flow Cytometry

Sun Apr 01 00:00:00 EDT 2018

The interplay of BMP4 and IL‑7 regulates the apoptosis of intestinal intraepithelial lymphocytes under conditions of ischemia̸reperfusion.

International journal of molecular medicine

Luo B,Chen K,Feng Q,Xiao W,Ma D,Yang H,Zhang C

Published figure using CD127 monoclonal antibody (Product # 11-1271-82) in Flow Cytometry

Tue May 01 00:00:00 EDT 2018

Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.

Nature communications

Sun C,Lan P,Han Q,Huang M,Zhang Z,Xu G,Song J,Wang J,Wei H,Zhang J,Sun R,Zhang C,Tian Z

Published figure using CD127 monoclonal antibody (Product # 11-1271-82) in Flow Cytometry

Wed Mar 28 00:00:00 EDT 2018

Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells.

Cell reports

Kirkling ME,Cytlak U,Lau CM,Lewis KL,Resteu A,Khodadadi-Jamayran A,Siebel CW,Salmon H,Merad M,Tsirigos A,Collin M,Bigley V,Reizis B

11-1271 was used in Flow cytometry/Cell sorting to examine the role of Notch signalling in the in vitro generation of classical dendritic cells.

Tue Jun 19 00:00:00 EDT 2018

General control non-derepressible 2 (GCN2) in T cells controls disease progression of autoimmune neuroinflammation.

Journal of neuroimmunology

Keil M,Sonner JK,Lanz TV,Oezen I,Bunse T,Bittner S,Meyer HV,Meuth SG,Wick W,Platten M

11127182 was used in flow cytometry to investigate the role of general control non-derepressible 2 in resolving autoimmune neuroinflammation

Mon Aug 15 00:00:00 EDT 2016

A simple, accurate and universal method for quantification of PCR.

BMC biotechnology

Boulter N,Suarez FG,Schibeci S,Sunderland T,Tolhurst O,Hunter T,Hodge G,Handelsman D,Simanainen U,Hendriks E,Duggan K

Published figure using CD127 monoclonal antibody (Product # 11-1271-82) in Flow Cytometry

Wed Mar 09 00:00:00 EST 2016

The GIY-YIG Type Endonuclease Ankyrin Repeat and LEM Domain-Containing Protein 1 (ANKLE1) Is Dispensable for Mouse Hematopoiesis.

PloS one

Braun J,Meixner A,Brachner A,Foisner R

11-1271 was used in Flow cytometry/Cell sorting to test whether ANKLE1 may contribute to Holliday junction resolution during DNA repair in mice.

Fri Aug 12 00:00:00 EDT 2016

ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation.

eLife

Pearson C,Thornton EE,McKenzie B,Schaupp AL,Huskens N,Griseri T,West N,Tung S,Seddon BP,Uhlig HH,Powrie F

11-1271 was used in Flow cytometry/Cell sorting to investigate how a small population of innate lymphoid cells (ILCs) has large effects on immune homeostasis, showing that ILC3s produce GM-CSF to orchestrate acute intestinal inflammation.

Mon Jan 18 00:00:00 EST 2016

Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells.

Nature immunology

Laidlaw BJ,Cui W,Amezquita RA,Gray SM,Guan T,Lu Y,Kobayashi Y,Flavell RA,Kleinstein SH,Craft J,Kaech SM

Published figure using CD127 monoclonal antibody (Product # 11-1271-82) in Flow Cytometry

Sat Aug 01 00:00:00 EDT 2015

Cis-regulatory mechanisms governing stem and progenitor cell transitions.

Science advances

Johnson KD,Kong G,Gao X,Chang YI,Hewitt KJ,Sanalkumar R,Prathibha R,Ranheim EA,Dewey CN,Zhang J,Bresnick EH

11-1271 was used in Flow cytometry/Cell sorting to illustrate a paradigm in which cis-elements in a locus differentially control stem and progenitor cell transitions.

Tue Sep 01 00:00:00 EDT 2015

WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.

The Journal of experimental medicine

Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z

11-1271 was used in Flow cytometry/Cell sorting to show that conditional WASH deletion in the haematopoietic system causes defective blood production of the host.

Mon Sep 22 00:00:00 EDT 2014

Type I interferon signaling enhances CD8+ T cell effector function and differentiation during murine gammaherpesvirus 68 infection.

Journal of virology

Jennings RN,Grayson JM,Barton ES

11-1271 was used in Flow cytometry/Cell sorting to assess T cell responses in IFNAR1(-/-) mice after MHV68 infection.

Mon Dec 01 00:00:00 EST 2014

Autophagy is a critical regulator of memory CD8(+) T cell formation.

eLife

Puleston DJ,Zhang H,Powell TJ,Lipina E,Sims S,Panse I,Watson AS,Cerundolo V,Townsend AR,Klenerman P,Simon AK

11-1271 was used in Flow cytometry/Cell sorting to show that mice lacking the autophagy gene Atg7 in T cells failed to establish CD8(+) T cell memory to influenza and MCMV infection.

Tue Nov 11 00:00:00 EST 2014

Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.

BMC biology

Reynolds C,Chong D,Raynsford E,Quigley K,Kelly D,Llewellyn-Hughes J,Altmann D,Boyton R

11-1271 was used in Flow cytometry/Cell sorting to study how the conformation of TCR alpha chain CDR3 favours different CD4 cytokine profiles.

Fri May 09 00:00:00 EDT 2014

Uterine natural killer cells severely decrease in number at gestation day 6 in mice.

Biology of reproduction

Takashima A,Ishikawa F,Kuwabara T,Tanaka Y,Kinoshita T,Ito M,Kakiuchi T

11-1271 was used in Flow cytometry/Cell sorting to study how uterine NK cells or their precursors migrate into the uterus, mature, and produce interferon-gamma to support pregnancy in mice.

Tue Oct 01 00:00:00 EDT 2013

Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo.

PloS one

Wu X,Satpathy AT,Kc W,Liu P,Murphy TL,Murphy KM

11-1271 was used in Flow cytometry/Cell sorting to investigate the role of Bcl11a in the development of dendritic cells, showing that it controls Flt3 expression in early hematopoietic progenitors and is required for pDC development.

Fri Jan 10 00:00:00 EST 2014

NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors.

Nature medicine

Alvarez-Breckenridge CA,Yu J,Price R,Wojton J,Pradarelli J,Mao H,Wei M,Wang Y,He S,Hardcastle J,Fernandez SA,Kaur B,Lawler SE,Vivier E,Mandelboim O,Moretta A,Caligiuri MA,Chiocca EA

11-1271 was used in Flow cytometry/Cell sorting to demonstrate that glioblastoma virotherapy is limited partially by an antiviral NK cell response involving specific NCRs, uncovering new potential targets to enhance cancer virotherapy.

Sat Dec 01 00:00:00 EST 2012

A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation.

Nature immunology

Ochiai K,Maienschein-Cline M,Mandal M,Triggs JR,Bertolino E,Sciammas R,Dinner AR,Clark MR,Singh H

Published figure using CD127 monoclonal antibody (Product # 11-1271-82) in Flow Cytometry

Sun Jan 22 00:00:00 EST 2012

IFNγ induces monopoiesis and inhibits neutrophil development during inflammation.

Blood

de Bruin AM,Libregts SF,Valkhof M,Boon L,Touw IP,Nolte MA

11-1271 was used in Flow cytometry/Cell sorting to demonstrate that the pro-inflammatory cytokine IFNγ is involved in orchestrating inflammation-induced myelopoiesis.

Thu Feb 09 00:00:00 EST 2012

ZBTB1 is a determinant of lymphoid development.

The Journal of experimental medicine

Siggs OM,Li X,Xia Y,Beutler B

11-1271 was used in Flow cytometry/Cell sorting to identify a mutation causative of complete and cell-intrinsic T cell deficiency.

Mon Jan 16 00:00:00 EST 2012

Thymus-derived rather than tumor-induced regulatory T cells predominate in brain tumors.

Neuro-oncology

Wainwright DA,Sengupta S,Han Y,Lesniak MS

11-1271 was used in Flow cytometry/Cell sorting to investigate whether brain-tumour-resident Tregs are thymus-derived natural Tregs or induced Tregs, showing that thymus-derived Tregs predominate.

Thu Dec 01 00:00:00 EST 2011

T. brucei infection reduces B lymphopoiesis in bone marrow and truncates compensatory splenic lymphopoiesis through transitional B-cell apoptosis.

PLoS pathogens

Bockstal V,Guirnalda P,Caljon G,Goenka R,Telfer JC,Frenkel D,Radwanska M,Magez S,Black SJ

11-1271 was used in Flow cytometry/Cell sorting to study how infection-induced deletion of transitional B cells prevents replenishment of mature B cell compartments during T. brucei infection.

Wed Jun 01 00:00:00 EDT 2011

Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/ PD-L1 pathway.

Aging cell

Lages CS,Lewkowich I,Sproles A,Wills-Karp M,Chougnet C

11-1271 was used in Flow cytometry/Cell sorting to suggest that blockade of the PD-1/PD-L1 is not likely to be efficient at restoring exhausted T-cell responses in aged hosts.

Fri Oct 01 00:00:00 EDT 2010

LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen.

Journal of immunology (Baltimore, Md. : 1950)

Vondenhoff MF,Greuter M,Goverse G,Elewaut D,Dewint P,Ware CF,Hoorweg K,Kraal G,Mebius RE

Fri May 01 00:00:00 EDT 2009

Effector/memory but not naive regulatory T cells are responsible for the loss of concomitant tumor immunity.

Journal of immunology (Baltimore, Md. : 1950)

Lin YC,Chang LY,Huang CT,Peng HM,Dutta A,Chen TC,Yeh CT,Lin CY

11-1271 was used in Flow cytometry/Cell sorting to study the contribution of various Treg cell types to the maintenance of concomitant tumour immunity.

Fri May 15 00:00:00 EDT 2009

Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells.

Nature immunology

Lee SW,Park Y,So T,Kwon BS,Cheroutre H,Mittler RS,Croft M

11-1271 was used in Flow cytometry/Cell sorting to show that the costimulatory molecule 4-1BB, and also its ligand 4-1BBL, is able to limit myelopoiesis and dendritic cell development.

Fri Aug 01 00:00:00 EDT 2008

IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response.

Blood

Rubinstein MP,Lind NA,Purton JF,Filippou P,Best JA,McGhee PA,Surh CD,Goldrath AW

11-1271 was used in Flow cytometry/Cell sorting to study IL-7 and IL-15 regulation of CD8+ T-cell subsets during contraction of the immune response.

Sat Nov 01 00:00:00 EDT 2008

Single-dose protection against Plasmodium berghei by a simian adenovirus vector using a human cytomegalovirus promoter containing intron A.

Journal of virology

Sridhar S,Reyes-Sandoval A,Draper SJ,Moore AC,Gilbert SC,Gao GP,Wilson JM,Hill AV

11-1271 was used in Flow cytometry/Cell sorting to compare efficacy of AdH5 and AdC6 vector vaccines expressing antigen under HCMV promotion.

Tue Apr 01 00:00:00 EDT 2008

Unique receptor repertoire in mouse uterine NK cells.

Journal of immunology (Baltimore, Md. : 1950)

Yadi H,Burke S,Madeja Z,Hemberger M,Moffett A,Colucci F

11-1271-82 was used in Flow Cytometry to define the receptor repertoire and phenotype of uterine NK cells at mid-gestation in mice.

Sat Nov 01 00:00:00 EDT 2008

Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis.

The American journal of pathology

Leithäuser F,Meinhardt-Krajina T,Fink K,Wotschke B,Möller P,Reimann J

Thu Jun 01 00:00:00 EDT 2006

Bioinformatics

Protein Aliases: CD127; IL 7 receptor; IL 7R a; IL 7R subunit alpha; IL 7R α; IL 7Ra; IL 7Rα; IL-7 receptor alpha chain; IL-7 receptor subunit alpha; IL-7R; IL-7R subunit alpha; IL-7R-alpha; IL-7RA; IL7 receptor; IL7 receptor subunit alpha; IL7R a; IL7R alpha; IL7R subunit alpha; IL7R α; IL7Rα; interleukin 7 receptor alpha chain; Interleukin-7 receptor subunit alpha; Interleukin7 receptor subunit alpha; MGC107557; sCD127; soluble IL 7 receptor; soluble IL 7R

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Gene Aliases: CD127; IL-7Ralpha; Il7r

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UniProt ID: (Mouse) P16872

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Entrez Gene ID: (Mouse) 16197

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Function(s)

cytokine receptor activity transmembrane signal receptor

Process(es)

cell morphogenesis negative regulation of T cell mediated cytotoxicity immunoglobulin production regulation of cell size positive regulation of gene expression cell growth T cell differentiation positive regulation of T cell differentiation in thymus B cell proliferation lymph node development homeostasis of number of cells

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD127 Monoclonal Antibody (A7R34), FITC, eBioscience™

CD127 Antibody (11-1271-82) in Flow

Product Details

11-1271-82

Immunohistochemistry (IHC)

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Recommended Isotype Control

Class

Type

Clone

Conjugate

Excitation/Emission Max

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

How to use the Panel Builder

Bioinformatics

Performance Guarantee

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