Invitrogen

CD279 (PD-1) Monoclonal Antibody (J43), Biotin, eBioscience™

CD279 (PD-1) Antibody in Flow Cytometry (Flow)

FIGURE: 1 / 43

CD279 (PD-1) Antibody (13-9985-82) in Flow

Nature communications 2022 - Prdm1 attenuates its effects on tumor growth inhibition through PD-L1-induced tumor immune evasion in immune-competent mice. a Representative subcutaneous tumors (left)/orthotopic transplantation tumors (right) collected from Hepa1-6-bearing C57BL/6 mice. b Tumor proliferation curves of subcutaneous xenografts in Hepa1-6-bearing C57BL/6 mice. Data presented as mean +- SEM. n = 6 mice per group. c Kaplan-Mei... View More

CD279 (PD-1) Antibody in Immunohistochemistry, Flow Cytometry (IHC, Flow)

Product Image Gallery

Product Details

13-9985-82

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Frozen) (IHC (F))

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

- -

Flow Cytometry (Flow)

0.25 µg/test

View 38 publications 38 publications

ELISA (ELISA)

View 1 publication 1 publication

Functional Assay (Functional)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Mouse

Published species

Mouse

Host/Isotype

Armenian hamster / IgG

Recommended Isotype Control

Armenian Hamster IgG Isotype Control (eBio299Arm), Biotin, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

J43

Conjugate

Biotin Biotin Biotin

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_467023

Product Specific Information

Description: The J43 monoclonal antibody reacts with mouse PD-1 (programmed death-1), a 55 kDa member of the Ig superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease in mice. PD-1 is expressed mainly on activated T and B lymphocytes. Two novel B7 Family members have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. It is reported that J43 inhibits the binding of mouse PD-L1-Ig and mouse PD-L2-Ig to PD-1/BHK transfected cells. When administrated in vivo, both intact and Fab of J43 are reported to enhance contact hypersensitivity and exacerbate acute GVHD similar to transfer of PD-1-deficient cells. Injection of J43 also exacerbates EAE and NOD diabetes as do specific antibodies to mouse PD-L1 and PD-L2.

Applications Reported: The J43 antibody has been reported for use in flow cytometric analysis.

Applications Tested: The J43 antibody has been tested by flow cytometric analysis of Con A-simulated mouse splenocytes and mouse PD-1 transfected cells. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury.

The Journal of clinical investigation

Sato Y,Oguchi A,Fukushima Y,Masuda K,Toriu N,Taniguchi K,Yoshikawa T,Cui X,Kondo M,Hosoi T,Komidori S,Shimizu Y,Fujita H,Jiang L,Kong Y,Yamanashi T,Seita J,Yamamoto T,Toyokuni S,Hamazaki Y,Hattori M,Yoshikai Y,Boor P,Floege J,Kawamoto H,Murakawa Y,Minato N,Yanagita M

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Tue Jan 18 00:00:00 EST 2022

Docetaxel remodels prostate cancer immune microenvironment and enhances checkpoint inhibitor-based immunotherapy.

Theranostics

Ma Z,Zhang W,Dong B,Xin Z,Ji Y,Su R,Shen K,Pan J,Wang Q,Xue W

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Mon Jul 18 00:00:00 EDT 2022

CD4⁺ CTLs Act as a Key Effector Population for Allograft Rejection of MSCs in a Donor MHC-II Dependent Manner in Injured Liver.

Aging and disease

Shen S,Li Y,Jin M,Fan D,Pan R,Lin A,Chen Y,Xiang L,Zhao RC,Shao J

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2022

Ultrasound combined with nanobubbles promotes systemic anticancer immunity and augments anti-PD1 efficacy.

Journal for immunotherapy of cancer

Hu J,He J,Wang Y,Zhao Y,Fang K,Dong Y,Chen Y,Zhang Y,Zhang C,Wang H,Tan J,Wang J,Zi R,Liu C,Liang H,Guo Y,Ou J

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Tue Mar 01 00:00:00 EST 2022

PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells.

Nature communications

Li Q,Zhang L,You W,Xu J,Dai J,Hua D,Zhang R,Yao F,Zhou S,Huang W,Dai Y,Zhang Y,Baheti T,Qian X,Pu L,Xu J,Xia Y,Zhang C,Tang J,Wang X

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Mon Dec 12 00:00:00 EST 2022

Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy.

Cell reports

Wang W,Wu S,Cen Z,Zhang Y,Chen Y,Huang Y,Cillo AR,Prokopec JS,Quarato G,Vignali DAA,Stewart-Ornstein J,Li S,Lu B,Gong YN

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Tue Nov 01 00:00:00 EDT 2022

NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.

Nature immunology

Gu M,Zhou X,Sohn JH,Zhu L,Jie Z,Yang JY,Zheng X,Xie X,Yang J,Shi Y,Brightbill HD,Kim JB,Wang J,Cheng X,Sun SC

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Histone deacetylase 3 represses cholesterol efflux during CD4⁺ T-cell activation.

eLife

Wilfahrt D,Philips RL,Lama J,Kizerwetter M,Shapiro MJ,McCue SA,Kennedy MM,Rajcula MJ,Zeng H,Shapiro VS

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Thu Dec 02 00:00:00 EST 2021

Ketogenic diet and ketone bodies enhance the anticancer effects of PD-1 blockade.

JCI insight

Ferrere G,Tidjani Alou M,Liu P,Goubet AG,Fidelle M,Kepp O,Durand S,Iebba V,Fluckiger A,Daillère R,Thelemaque C,Grajeda-Iglesias C,Alves Costa Silva C,Aprahamian F,Lefevre D,Zhao L,Ryffel B,Colomba E,Arnedos M,Drubay D,Rauber C,Raoult D,Asnicar F,Spector T,Segata N,Derosa L,Kroemer G,Zitvogel L

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Mon Jan 25 00:00:00 EST 2021

PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer.

Nature communications

Sun Y,Lu D,Yin Y,Song J,Liu Y,Hao W,Qi F,Zhang G,Zhang X,Liu L,Lin Z,Liang H,Zhao X,Jin Y,Yin Y

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Thu Aug 26 00:00:00 EDT 2021

Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity.

Cell reports

Zhou X,Zhu X,Li C,Li Y,Ye Z,Shapiro VS,Copland JA,Hitosugi T,Bernlohr DA,Sun J,Zeng H

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Tue Jan 05 00:00:00 EST 2021

Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.

Frontiers in immunology

Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Tue Jan 11 00:00:00 EST 2022

Activation of regulatory T cells triggers specific changes in glycosylation associated with Siglec-1-dependent inflammatory responses.

Wellcome open research

Wu G,Murugesan G,Nagala M,McCraw A,Haslam SM,Dell A,Crocker PR

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Tue Mar 01 00:00:00 EST 2022

Serum HBsAg clearance has minimal impact on CD8+ T cell responses in mouse models of HBV infection.

The Journal of experimental medicine

Fumagalli V,Di Lucia P,Venzin V,Bono EB,Jordan R,Frey CR,Delaney W,Chisari FV,Guidotti LG,Iannacone M

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Mon Nov 02 00:00:00 EST 2020

B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection.

The Journal of experimental medicine

Arroyo EN,Pepper M

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Mon Feb 03 00:00:00 EST 2020

Inhibition of the Wnt/β-catenin pathway enhances antitumor immunity in ovarian cancer.

Therapeutic advances in medical oncology

Doo DW,Meza-Perez S,Londoño AI,Goldsberry WN,Katre AA,Boone JD,Moore DJ,Hudson CT,Betella I,McCaw TR,Gangrade A,Bao R,Luke JJ,Yang ES,Birrer MJ,Starenki D,Cooper SJ,Buchsbaum DJ,Norian LA,Randall TD,Arend RC

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Thu Apr 14 00:00:00 EDT 2022

Gene silencing of indoleamine 2,3-dioxygenase 1 inhibits lung cancer growth by suppressing T-cell exhaustion.

Oncology letters

Shang K,Wang Z,Hu Y,Huang Y,Yuan K,Yu Y

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2020

Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease.

Cell reports

Nguyen HD,Ticer T,Bastian D,Kuril S,Li H,Du H,Yan C,Yu XZ

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Tue Oct 27 00:00:00 EDT 2020

5-Azacytidine Potentiates Anti-tumor Immunity in a Model of Pancreatic Ductal Adenocarcinoma.

Frontiers in immunology

Ebelt ND,Zuniga E,Johnson BL,Diamond DJ,Manuel ER

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Fri Mar 26 00:00:00 EDT 2021

SLAMF6 deficiency augments tumor killing and skews toward an effector phenotype revealing it as a novel T cell checkpoint.

eLife

Hajaj E,Eisenberg G,Klein S,Frankenburg S,Merims S,Ben David I,Eisenhaure T,Henrickson SE,Villani AC,Hacohen N,Abudi N,Abramovich R,Cohen JE,Peretz T,Veillette A,Lotem M

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in ELISA

Tue Mar 03 00:00:00 EST 2020

The Selenoprotein MsrB1 Instructs Dendritic Cells to Induce T-Helper 1 Immune Responses.

Antioxidants (Basel, Switzerland)

Lee HJ,Park JS,Yoo HJ,Lee HM,Lee BC,Kim JH

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Tue Oct 20 00:00:00 EDT 2020

Endogenous retroviral proteins provide an immunodominant but not requisite antigen in a murine immunotherapy tumor model.

Oncoimmunology

Ye X,Waite JC,Dhanik A,Gupta N,Zhong M,Adler C,Malahias E,Ni M,Wei Y,Gurer C,Zhang W,Macdonald LE,Murphy AJ,Sleeman MA,Skokos D

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Wed May 13 00:00:00 EDT 2020

Combination PD-1 and PD-L1 Blockade Promotes Durable Neoantigen-Specific T Cell-Mediated Immunity in Pancreatic Ductal Adenocarcinoma.

Cell reports

Burrack AL,Spartz EJ,Raynor JF,Wang I,Olson M,Stromnes IM

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Tue Aug 20 00:00:00 EDT 2019

Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.

Cell

Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Thu Jan 25 00:00:00 EST 2018

PD-1 Blockade Overcomes Adaptive Immune Resistance in Treatment with Anchored-GM-CSF Bladder Cancer Cells Vaccine.

Journal of Cancer

Zhang X,Shi X,Li J,Mo L,Hu Z,Gao J,Wu S,Long Z

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Immunohistochemistry

Thu Oct 01 00:00:00 EDT 2020

PD-1 Blockade Overcomes Adaptive Immune Resistance in Treatment with Anchored-GM-CSF Bladder Cancer Cells Vaccine.

Journal of Cancer

Zhang X,Shi X,Li J,Mo L,Hu Z,Gao J,Wu S,Long Z

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Immunohistochemistry

Thu Oct 01 00:00:00 EDT 2020

Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination.

Cancer research

Jiang H,Rivera-Molina Y,Gomez-Manzano C,Clise-Dwyer K,Bover L,Vence LM,Yuan Y,Lang FF,Toniatti C,Hossain MB,Fueyo J

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Sat Jul 15 00:00:00 EDT 2017

Mice Immunized with IgG Anti-Sheep Red Blood Cells (SRBC) Together With SRBC Have a Suppressed Anti-SRBC Antibody Response but Generate Germinal Centers and Anti-IgG Antibodies in Response to the Passively Administered IgG.

Frontiers in immunology

Bergström JJE,Heyman B

13-9985 was used in Flow cytometry/Cell sorting to made the surprising observation that mice immunized with IgG anti-sheep red blood cells (SRBC) and SRBC, in spite of a severely suppressed anti-SRBC response, have a strong germinal center response.

Wed Nov 20 00:00:00 EST 2019

Cblb-deficient T cells are less susceptible to PD-L1-mediated inhibition.

Oncotarget

Peer S,Baier G,Gruber T

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Tue Jun 27 00:00:00 EDT 2017

Therapeutic efficacy of combined vaccination against tumor pericyte-associated antigens DLK1 and DLK2 in mice.

Oncoimmunology

Fabian KP,Chi-Sabins N,Taylor JL,Fecek R,Weinstein A,Storkus WJ

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.

Nature communications

Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Mon Feb 13 00:00:00 EST 2017

Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression.

Oncoimmunology

Chen L,Yi X,Goswami S,Ahn YH,Roybal JD,Yang Y,Diao L,Peng D,Peng D,Fradette JJ,Wang J,Byers LA,Kurie JM,Ullrich SE,Qin FX,Gibbons DL

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomas.

Oncoimmunology

Sonner JK,Deumelandt K,Ott M,Thomé CM,Rauschenbach KJ,Schulz S,Munteanu B,Mohapatra S,Adam I,Hofer AC,Feuerer M,Opitz CA,Hopf C,Wick W,Platten M

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.

Nature communications

Chen L,Gibbons DL,Goswami S,Cortez MA,Ahn YH,Byers LA,Zhang X,Yi X,Dwyer D,Lin W,Diao L,Wang J,Roybal J,Patel M,Ungewiss C,Peng D,Antonia S,Mediavilla-Varela M,Robertson G,Suraokar M,Welsh JW,Erez B,Wistuba II,Chen L,Peng D,Wang S,Ullrich SE,Heymach JV,Kurie JM,Qin FX

Published figure using CD279 (PD-1) monoclonal antibody (Product # 13-9985-82) in Flow Cytometry

Tue Oct 28 00:00:00 EDT 2014

Th2 cell-intrinsic hypo-responsiveness determines susceptibility to helminth infection.

PLoS pathogens

van der Werf N,Redpath SA,Azuma M,Yagita H,Taylor MD

13-9985 was used in Flow cytometry/Cell sorting to demonstrate that during chronic Litomosoides sigmodontis infection, CD4(+) Th2 cells are conditioned towards an intrinsically hypo-responsive phenotype.

Fri Mar 01 00:00:00 EST 2013

Recipient myeloid-derived immunomodulatory cells induce PD-1 ligand-dependent donor CD4+Foxp3+ regulatory T cell proliferation and donor-recipient immune tolerance after murine nonmyeloablative bone marrow transplantation.

Journal of immunology (Baltimore, Md. : 1950)

van der Merwe M,Abdelsamed HA,Seth A,Ong T,Vogel P,Pillai AB

13-9985 was used in Flow cytometry/Cell sorting to investigate the specific mechanisms of immune tolerance following TLI/ATS conditioning, showing the induction of PD-1 ligand-dependent donor Treg proliferation and donor-recipient immune tolerance.

Sun Dec 01 00:00:00 EST 2013

Programmed cell death 1 suppresses B-1b cell expansion and long-lived IgG production in response to T cell-independent type 2 antigens.

Journal of immunology (Baltimore, Md. : 1950)

Haas KM

13-9985 was used in cell sorting to perform detailed analysis of the B cell response to 2,4,6-trinitrophenol (TNP)-Ficoll using normal mice.

Tue Nov 15 00:00:00 EST 2011

Effects of irradiating adult mdx mice before full-length dystrophin cDNA transfer on host anti-dystrophin immunity.

Gene therapy

Eghtesad S,Zheng H,Nakai H,Epperly MW,Clemens PR

13-9985 was used in Immunohistochemistry to demonstrate that dystrophin gene transfer induces anti-dystrophin immunity that are diminished by temporal removal of host immune cells.

Wed Sep 01 00:00:00 EDT 2010

The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding.

Nature immunology

Fazilleau N,McHeyzer-Williams LJ,Rosen H,McHeyzer-Williams MG

13-9985 was used in Flow cytometry/Cell sorting to study the antigen-specific mechanisms that program specialised effector follicular helper T cell function in vivo.

Wed Apr 01 00:00:00 EDT 2009

Acquisition of anergic and suppressive activities in transforming growth factor-beta-costimulated CD4+CD25- T cells.

International immunology

Park HB,Paik DJ,Jang E,Hong S,Youn J

13-9985 was used in Flow cytometry/Cell sorting to investigate the potential role of TGF-beta in the peripheral induction of regulatory phenotypes in conventional CD4(+)CD25(-) T cells.

Sun Aug 01 00:00:00 EDT 2004

The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice.

The Journal of experimental medicine

Ansari MJ,Salama AD,Chitnis T,Smith RN,Yagita H,Akiba H,Yamazaki T,Azuma M,Iwai H,Khoury SJ,Auchincloss H,Sayegh MH

Mon Jul 07 00:00:00 EDT 2003

The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice.

The Journal of experimental medicine

Ansari MJ,Salama AD,Chitnis T,Smith RN,Yagita H,Akiba H,Yamazaki T,Azuma M,Iwai H,Khoury SJ,Auchincloss H,Sayegh MH

Mon Jul 07 00:00:00 EDT 2003

The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice.

The Journal of experimental medicine

Ansari MJ,Salama AD,Chitnis T,Smith RN,Yagita H,Akiba H,Yamazaki T,Azuma M,Iwai H,Khoury SJ,Auchincloss H,Sayegh MH

Mon Jul 07 00:00:00 EDT 2003

Bioinformatics

Protein Aliases: CD279; hPD1; mPD-1; Programmed cell death protein 1; Protein PD-1; Protein PD1; sCD279; soluble CD279

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Gene Aliases: Ly101; PD-1; Pd1; Pdc1; Pdcd1

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UniProt ID: (Mouse) Q02242

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Entrez Gene ID: (Mouse) 18566

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Function(s)

protein binding

Process(es)

immune system process negative regulation of tolerance induction apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of T cell apoptotic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD279 (PD-1) Monoclonal Antibody (J43), Biotin, eBioscience™

CD279 (PD-1) Antibody (13-9985-82) in Flow

Product Details

13-9985-82

Immunohistochemistry (IHC)

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

ELISA (ELISA)

Functional Assay (Functional)

Species Reactivity

Published species

Host/Isotype

Recommended Isotype Control

Class

Type

Clone

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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