Product References
Lamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiovascular cell fate and function.
Nature communications
Wang Y,Elsherbiny A,Kessler L,Cordero J,Shi H,Serke H,Lityagina O,Trogisch FA,Mohammadi MM,El-Battrawy I,Backs J,Wieland T,Heineke J,Dobreva G
17-5821-81 was used in Flow cytometry/Cell sorting to show that lamin A/C plays a key role in chromatin organization in embryonic stem cells (ESCs), which safeguards naïve pluripotency and ensures proper cell fate choices during cardiogenesis.
Fri Nov 04 00:00:00 EDT 2022
Lamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiovascular cell fate and function.
Nature communications
Wang Y,Elsherbiny A,Kessler L,Cordero J,Shi H,Serke H,Lityagina O,Trogisch FA,Mohammadi MM,El-Battrawy I,Backs J,Wieland T,Heineke J,Dobreva G
17-5821-81 was used in Flow cytometry/Cell sorting to show that lamin A/C plays a key role in chromatin organization in embryonic stem cells (ESCs), which safeguards naïve pluripotency and ensures proper cell fate choices during cardiogenesis.
Fri Nov 04 00:00:00 EDT 2022
Operation of a TCA cycle subnetwork in the mammalian nucleus.
Science advances
Kafkia E,Andres-Pons A,Ganter K,Seiler M,Smith TS,Andrejeva A,Jouhten P,Pereira F,Franco C,Kuroshchenkova A,Leone S,Sawarkar R,Boston R,Thaventhiran J,Zaugg JB,Lilley KS,Lancrin C,Beck M,Patil KR
17-5821-81 was used in Immunocytochemistry to demonstrate operation of an extended metabolic pathway in the nucleus, warranting a revision of the canonical view on metabolic compartmentalization.
Fri Sep 02 00:00:00 EDT 2022
Iron deficiency disrupts embryonic haematopoiesis but not the endothelial to haematopoietic transition.
Scientific reports
Shvartsman M,Bilican S,Lancrin C
17-5821-81 was used in Magnetic cell separation to explore how cellular iron status affects embryonic haematopoiesis.
Tue Apr 23 00:00:00 EDT 2019
SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells.
Nature communications
Chagraoui H,Kristiansen MS,Ruiz JP,Serra-Barros A,Richter J,Hall-Ponselé E,Gray N,Waithe D,Clark K,Hublitz P,Repapi E,Otto G,Sopp P,Taylor S,Thongjuea S,Vyas P,Porcher C
Published figure using CD309 (FLK1) monoclonal antibody (Product # 17-5821-81) in Flow Cytometry
Tue Dec 18 00:00:00 EST 2018
Single-cell transcriptomics reveals a new dynamical function of transcription factors during embryonic hematopoiesis.
eLife
Bergiers I,Andrews T,Vargel Bölükbaşı Ö,Buness A,Janosz E,Lopez-Anguita N,Ganter K,Kosim K,Celen C,Itır Perçin G,Collier P,Baying B,Benes V,Hemberg M,Lancrin C
Tue Mar 20 00:00:00 EDT 2018
Antifibrotic role of vascular endothelial growth factor in pulmonary fibrosis.
JCI insight
Murray LA,Habiel DM,Hohmann M,Camelo A,Shang H,Zhou Y,Coelho AL,Peng X,Gulati M,Crestani B,Sleeman MA,Mustelin T,Moore MW,Ryu C,Osafo-Addo AD,Elias JA,Lee CG,Hu B,Herazo-Maya JD,Knight DA,Hogaboam CM,Herzog EL
Published figure using CD309 (FLK1) monoclonal antibody (Product # 17-5821-81) in Flow Cytometry
Thu Aug 17 00:00:00 EDT 2017
Intravenous Arginine Administration Promotes Proangiogenic Cells Mobilization and Attenuates Lung Injury in Mice with Polymicrobial Sepsis.
Nutrients
Yeh CL,Pai MH,Shih YM,Shih JM,Yeh SL
17-5821 was used in Flow cytometry/Cell sorting to study the potential beneficial effects of intravenous administration of Arginine shortly after the onset of sepsis in mice.
Wed May 17 00:00:00 EDT 2017
Induction of Indoleamine 2,3-dioxygenase by Pre-treatment with Poly(I:C) May Enhance the Efficacy of MSC Treatment in DSS-induced Colitis.
Immune network
Ryu DB,Lim JY,Lee SE,Park G,Min CK
17-5821 was used in Flow cytometry/Cell sorting to determine whether TLR ligands can enhance the therapeutic efficacy of mesenchymal stem cells for treating inflammatory disorders.
Thu Dec 01 00:00:00 EST 2016
Erk5 Is a Key Regulator of Naive-Primed Transition and Embryonic Stem Cell Identity.
Cell reports
Williams CA,Fernandez-Alonso R,Wang J,Toth R,Gray NS,Findlay GM
17-5821 was used in Flow cytometry/Cell sorting to investigate the mechanisms that control naive-primed pluripotent transition of embryonic stem cells.
Tue Aug 16 00:00:00 EDT 2016
Activation of the TGFβ pathway impairs endothelial to haematopoietic transition.
Scientific reports
Vargel Ö,Zhang Y,Kosim K,Ganter K,Foehr S,Mardenborough Y,Shvartsman M,Enright AJ,Krijgsveld J,Lancrin C
17-5821 was used in Flow cytometry/Cell sorting to assess the contribution of transforming growth factor-beta 1 signalling in key haematological developmental processes during embryogenesis.
Fri Feb 19 00:00:00 EST 2016
The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors.
Cell stem cell
Caputo L,Witzel HR,Kolovos P,Cheedipudi S,Looso M,Mylona A,van IJcken WF,Laugwitz KL,Evans SM,Braun T,Soler E,Grosveld F,Dobreva G
17-5821 was used in Chromatin immunoprecipitation to show how the Isl1/Ldb1 complex orchestrates a network for heart-specific transcriptional regulation and coordination in three-dimensional space during cardiogenesis.
Thu Sep 03 00:00:00 EDT 2015
The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors.
Cell stem cell
Caputo L,Witzel HR,Kolovos P,Cheedipudi S,Looso M,Mylona A,van IJcken WF,Laugwitz KL,Evans SM,Braun T,Soler E,Grosveld F,Dobreva G
17-5821 was used in Chromatin immunoprecipitation to show how the Isl1/Ldb1 complex orchestrates a network for heart-specific transcriptional regulation and coordination in three-dimensional space during cardiogenesis.
Thu Sep 03 00:00:00 EDT 2015
FOXF1 inhibits hematopoietic lineage commitment during early mesoderm specification.
Development (Cambridge, England)
Fleury M,Eliades A,Carlsson P,Lacaud G,Kouskoff V
17-5821 was used in Flow cytometry/Cell sorting to investigate the lineage specification of early mesodermal precursors expressing or not the Forkhead transcription factor FOXF1.
Thu Oct 01 00:00:00 EDT 2015
Endoglin potentiates nitric oxide synthesis to enhance definitive hematopoiesis.
Biology open
Nasrallah R,Knezevic K,Thai T,Thomas SR,Göttgens B,Lacaud G,Kouskoff V,Pimanda JE
17582181 was used in flow cytometry to investigate the role of endoglin in the development of hematopoietic cells.
Fri May 15 00:00:00 EDT 2015
Histone Demethylases KDM4A and KDM4C Regulate Differentiation of Embryonic Stem Cells to Endothelial Cells.
Stem cell reports
Wu L,Wary KK,Revskoy S,Gao X,Tsang K,Komarova YA,Rehman J,Malik AB
17-5821 was used in Flow cytometry/Cell sorting to demonstrate the essential role of KDM4A and KDM4C in murine embryonic stem cell differentiation to endothelial cells.
Tue Jul 14 00:00:00 EDT 2015
Mesenchymal-endothelial transition contributes to cardiac neovascularization.
Nature
Ubil E,Duan J,Pillai IC,Rosa-Garrido M,Wu Y,Bargiacchi F,Lu Y,Stanbouly S,Huang J,Rojas M,Vondriska TM,Stefani E,Deb A
17-5821 was used in Flow cytometry/Cell sorting to demonstrate that mesenchymal-to-endothelial transition contributes to neovascularization of the injured heart.
Thu Oct 30 00:00:00 EDT 2014
Notch pathway targets proangiogenic regulator Sox17 to restrict angiogenesis.
Circulation research
Lee SH,Lee S,Yang H,Song S,Kim K,Saunders TL,Yoon JK,Koh GY,Kim I
17-5821 was used in Flow cytometry/Cell sorting to specify the role of Sox17 and its relationship with the Notch pathway in sprouting angiogenesis in mice.
Mon Jul 07 00:00:00 EDT 2014
SOX9 accelerates ESC differentiation to three germ layer lineages by repressing SOX2 expression through P21 (WAF1/CIP1).
Development (Cambridge, England)
Yamamizu K,Schlessinger D,Ko MS
17-5821 was used in Flow cytometry/Cell sorting to explore a molecular cascade that is potentially an early step in the programming of ESC differentiation.
Sat Nov 01 00:00:00 EDT 2014
Expression of podocalyxin separates the hematopoietic and vascular potentials of mouse embryonic stem cell-derived mesoderm.
Stem cells (Dayton, Ohio)
Zhang H,Nieves JL,Fraser ST,Isern J,Douvaras P,Papatsenko D,D'Souza SL,Lemischka IR,Dyer MA,Baron MH
Published figure using CD309 (FLK1) monoclonal antibody (Product # 17-5821-81) in Flow Cytometry
Wed Jan 01 00:00:00 EST 2014
Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages.
Developmental biology
Shi X,Richard J,Zirbes KM,Gong W,Lin G,Kyba M,Thomson JA,Koyano-Nakagawa N,Garry DJ
17-5821 was used in Flow cytometry/Cell sorting to propose that Gata2 functions as a cofactor of Etv2 in the transcriptional regulation of mesodermal progenitors during embryogenesis.
Thu May 15 00:00:00 EDT 2014
CD39 modulates hematopoietic stem cell recruitment and promotes liver regeneration in mice and humans after partial hepatectomy.
Annals of surgery
Schmelzle M,Duhme C,Junger W,Salhanick SD,Chen Y,Wu Y,Toxavidis V,Csizmadia E,Han L,Bian S,Fürst G,Nowak M,Karp SJ,Knoefel WT,Esch JSA,Robson SC
17-5821 was used in Flow cytometry/Cell sorting to explore the effect of CD39 family-derived ectonucleotidases on hematopoietic stem cell mobility and function following liver injury.
Mon Apr 01 00:00:00 EDT 2013
Kupffer cells potentiate liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1.
Journal of leukocyte biology
Hutchins NA,Wang F,Wang Y,Chung CS,Ayala A
17-5821 was used in Flow cytometry/Cell sorting to study Kupffer cell-mediated potentiation of liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1.
Fri Nov 01 00:00:00 EDT 2013
Nkx2-5 mediates differential cardiac differentiation through interaction with Hoxa10.
Stem cells and development
Behrens AN,Iacovino M,Lohr JL,Ren Y,Zierold C,Harvey RP,Kyba M,Garry DJ,Martin CM
Published figure using CD309 (FLK1) monoclonal antibody (Product # 17-5821-81) in Flow Cytometry
Thu Aug 01 00:00:00 EDT 2013
Characterization of cardiac-resident progenitor cells expressing high aldehyde dehydrogenase activity.
BioMed research international
Roehrich ME,Spicher A,Milano G,Vassalli G
17-5821 was used in Flow cytometry/Cell sorting to investigate the presence of cardiac-resident progenitor cells with high aldehyde dehydrogenase activity isolated from mouse hearts.
Tue Sep 03 00:00:00 EDT 2013
Etv2 rescues Flk1 mutant embryoid bodies.
Genesis (New York, N.Y. : 2000)
Rasmussen TL,Martin CM,Walter CA,Shi X,Perlingeiro R,Koyano-Nakagawa N,Garry DJ
Published figure using CD309 (FLK1) monoclonal antibody (Product # 17-5821-81) in Flow Cytometry
Mon Jul 01 00:00:00 EDT 2013
Etv2 rescues Flk1 mutant embryoid bodies.
Genesis (New York, N.Y. : 2000)
Rasmussen TL,Martin CM,Walter CA,Shi X,Perlingeiro R,Koyano-Nakagawa N,Garry DJ
Published figure using CD309 (FLK1) monoclonal antibody (Product # 17-5821-81) in Flow Cytometry
Mon Jul 01 00:00:00 EDT 2013
DNA methylation restricts lineage-specific functions of transcription factor Gata4 during embryonic stem cell differentiation.
PLoS genetics
Oda M,Kumaki Y,Shigeta M,Jakt LM,Matsuoka C,Yamagiwa A,Niwa H,Okano M
17-5821 was used in Immunocytochemistry to study DNA methylation during embryonic stem cell differentiation.
Sat Jun 01 00:00:00 EDT 2013
Flk1+ and VE-cadherin+ endothelial cells derived from iPSCs recapitulates vascular development during differentiation and display similar angiogenic potential as ESC-derived cells.
PloS one
Kohler EE,Wary KK,Li F,Chatterjee I,Urao N,Toth PT,Ushio-Fukai M,Rehman J,Park C,Malik AB
17-5821 was used in Flow cytometry/Cell sorting to study and compare the angiogenic characteristics of mouse embryonic stem cells and mouse induced pluripotent stem cells.
Mon Feb 23 00:00:00 EST 2015
Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.
The Journal of experimental medicine
Satpathy AT,KC W,Albring JC,Edelson BT,Kretzer NM,Bhattacharya D,Murphy TL,Murphy KM
17-5821 was used in Flow cytometry/Cell sorting to identify Zbtb46 as a transcription factor selectively expressed by classical DCs and their committed progenitors.
Mon Jun 04 00:00:00 EDT 2012
Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression.
Stem cells (Dayton, Ohio)
Koyano-Nakagawa N,Kweon J,Iacovino M,Shi X,Rasmussen TL,Borges L,Zirbes KM,Li T,Perlingeiro RC,Kyba M,Garry DJ
Published figure using CD309 (FLK1) monoclonal antibody (Product # 17-5821-81) in Flow Cytometry
Wed Aug 01 00:00:00 EDT 2012
Endothelial differentiation by multipotent fetal mouse lung mesenchymal cells.
Stem cells and development
Yamamoto Y,Baldwin HS,Prince LS
17-5821 was used in Flow cytometry/Cell sorting to develop and characterize a novel fetal mouse lung cell model of mesenchymal to endothelial differentiation.
Sun Jun 10 00:00:00 EDT 2012
VEGF/Flk1 signaling cascade transactivates Etv2 gene expression.
PloS one
Rasmussen TL,Shi X,Wallis A,Kweon J,Zirbes KM,Koyano-Nakagawa N,Garry DJ
Mon May 13 00:00:00 EDT 2013
Angiopoietin-1 promotes endothelial differentiation from embryonic stem cells and induced pluripotent stem cells.
Blood
Joo HJ,Kim H,Park SW,Cho HJ,Kim HS,Lim DS,Chung HM,Kim I,Han YM,Koh GY
17-5821 was used in Flow cytometry/Cell sorting to study the role of Ang1/Tie2 signalling in ESC differentiation.
Thu Aug 25 00:00:00 EDT 2011
Recapitulation of the embryonic cardiovascular progenitor cell niche.
Biomaterials
Schenke-Layland K,Nsair A,Van Handel B,Angelis E,Gluck JM,Votteler M,Goldhaber JI,Mikkola HK,Kahn M,Maclellan WR
Published figure using CD309 (FLK1) monoclonal antibody (Product # 17-5821-81) in Flow Cytometry
Fri Apr 01 00:00:00 EDT 2011
ER71 directs mesodermal fate decisions during embryogenesis.
Development (Cambridge, England)
Rasmussen TL,Kweon J,Diekmann MA,Belema-Bedada F,Song Q,Bowlin K,Shi X,Ferdous A,Li T,Kyba M,Metzger JM,Koyano-Nakagawa N,Garry DJ
17-5821 was used in Flow cytometry/Cell sorting to further define the functional role for ER71 in cell lineage decisions using genetically modified mouse models.
Tue Nov 01 00:00:00 EDT 2011
Choice of random rather than imprinted X inactivation in female embryonic stem cell-derived extra-embryonic cells.
Development (Cambridge, England)
Murakami K,Araki K,Ohtsuka S,Wakayama T,Niwa H
17-5821 was used in Flow cytometry/Cell sorting to investigate the mode of X-inactivation during the differentiation of mouse embryonic stem cells toward trophectoderm and primitive ectoderm lineages.
Sat Jan 01 00:00:00 EST 2011
A triple-targeted ultrasound contrast agent provides improved localization to tumor vasculature.
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
Warram JM,Sorace AG,Saini R,Umphrey HR,Zinn KR,Hoyt K
Published figure using CD309 (FLK1) monoclonal antibody (Product # 17-5821-81) in Flow Cytometry
Fri Jul 01 00:00:00 EDT 2011
The homeobox gene Hhex regulates the earliest stages of definitive hematopoiesis.
Blood
Paz H,Lynch MR,Bogue CW,Gasson JC
17-5821 was used in Flow cytometry/Cell sorting to show that Hhex is a regulator of hematopoietic development and necessary for the maturation and proliferation of the hematopoietic progenitors.
Thu Aug 26 00:00:00 EDT 2010
Major histocompatibility complex-I expression on embryonic stem cell-derived vascular progenitor cells is critical for syngeneic transplant survival.
Stem cells (Dayton, Ohio)
Ma M,Ding S,Lundqvist A,San H,Fang F,Konoplyannikov M,Berry C,Beltran LE,Chen G,Kovacic JC,Boehm M
Published figure using CD309 (FLK1) monoclonal antibody (Product # 17-5821-81) in Flow Cytometry
Wed Sep 01 00:00:00 EDT 2010
Characterization of endothelial progenitor cells mobilization following cutaneous wounding.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Morris LM,Klanke CA,Lang SA,Pokall S,Maldonado AR,Vuletin JF,Alaee D,Keswani SG,Lim FY,Crombleholme TM
17-5821 was used in Flow cytometry/Cell sorting to characterize bone marrow (BM)-derived endothelial progenitor cell (EPC) mobilization following cutaneous wounding in mice.
Mon Nov 15 00:00:00 EST 2010
Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development.
Hepatology (Baltimore, Md.)
Asahina K,Tsai SY,Li P,Ishii M,Maxson RE,Sucov HM,Tsukamoto H
Published figure using CD309 (FLK1) monoclonal antibody (Product # 17-5821-81) in Flow Cytometry
Sun Mar 01 00:00:00 EST 2009
Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages.
Stem cells (Dayton, Ohio)
Schenke-Layland K,Rhodes KE,Angelis E,Butylkova Y,Heydarkhan-Hagvall S,Gekas C,Zhang R,Goldhaber JI,Mikkola HK,Plath K,MacLellan WR
17-5821 was used in Flow cytometry/Cell sorting to identify the capacity of iPS cells to differentiate into Flk1-positive progenitors and their mesodermal progeny.
Sun Jun 01 00:00:00 EDT 2008
Prospective isolation of skeletal muscle stem cells with a Pax7 reporter.
Stem cells (Dayton, Ohio)
Bosnakovski D,Xu Z,Li W,Thet S,Cleaver O,Perlingeiro RC,Kyba M
17-5821 was used in Flow cytometry/Cell sorting to establish a novel model for the study of muscle stem cell physiology and a culture system for expansion of engraftable muscle progenitors.
Mon Dec 01 00:00:00 EST 2008