Invitrogen

HLA-DR Monoclonal Antibody (LN3), FITC, eBioscience™

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

34 Published Figures

37 References

View all (121) HLA-DR antibodies

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Tech Support

Datasheet

Protocols

Questions & Answers

Tech Support

HLA-DR Antibody in Flow Cytometry (Flow)

FIGURE: 1 / 36

HLA-DR Antibody (11-9956-42) in Flow

Staining of normal human peripheral blood cells with Mouse IgG2b K Isotype Control FITC (Product # 11-4732-42) (blue histogram) or Anti-Human HLA-DR FITC (purple histogram). Cells in the lymphocyte (left) or monocyte (right) gate were used for analysis.

HLA-DR Antibody in Immunocytochemistry (ICC/IF)

HLA-DR Antibody in Immunohistochemistry (IHC)

Product Image Gallery

Product Details

11-9956-42

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Frozen) (IHC (F))

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Flow Cytometry (Flow)

5 µL (0.125 µg)/test

View 28 publications 28 publications

ELISA (ELISA)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Mouse / IgG2b, kappa

Recommended Isotype Control

Mouse IgG2b kappa Isotype Control (eBMG2b), FITC, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

LN3

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra

Form

Liquid

Concentration

5 µL/Test

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with 0.2% BSA

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2572544

Product Specific Information

Description: The LN3 mAb reacts with the human major histocompatibility complex (MHC) class II, HLA-DR. HLA-DR is expressed on the surface of human antigen presenting cells (APC) including B cells, monocytes, macrophages, DCs, and activated T cells. HLA-DR is a heterodimeric transmembrane protein composed of alpha and beta subunits and plays an important role in the presentation of peptides to CD4+ T lymphocytes.

Applications Reported: This LN3 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This LN3 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.125 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.

Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter.

Acta neuropathologica communications

Miedema A,Gerrits E,Brouwer N,Jiang Q,Kracht L,Meijer M,Nutma E,Peferoen-Baert R,Pijnacker ATE,Wesseling EM,Wijering MHC,Gabius HJ,Amor S,Eggen BJL,Kooistra SM

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Immunohistochemistry (Frozen)

Fri Jan 28 00:00:00 EST 2022

Activated CD4⁺ T cells and CD14^hiCD16⁺ monocytes correlate with antibody response following influenza virus infection in humans.

Cell reports. Medicine

Wong SS,Oshansky CM,Guo XJ,Ralston J,Wood T,Reynolds GE,Seeds R,Jelley L,Waite B,Jeevan T,Zanin M,Widdowson MA,Huang QS,Thomas PG,Webby RJ

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Flow Cytometry

Tue Apr 20 00:00:00 EDT 2021

The role of irreversible electroporation in promoting M1 macrophage polarization via regulating the HMGB1-RAGE-MAPK axis in pancreatic cancer.

Oncoimmunology

He C,Sun S,Zhang Y,Xie F,Li S

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Flow Cytometry

Thu Mar 11 00:00:00 EST 2021

The role of irreversible electroporation in promoting M1 macrophage polarization via regulating the HMGB1-RAGE-MAPK axis in pancreatic cancer.

Oncoimmunology

He C,Sun S,Zhang Y,Xie F,Li S

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Flow Cytometry

Thu Mar 11 00:00:00 EST 2021

The role of irreversible electroporation in promoting M1 macrophage polarization via regulating the HMGB1-RAGE-MAPK axis in pancreatic cancer.

Oncoimmunology

He C,Sun S,Zhang Y,Xie F,Li S

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Flow Cytometry

Thu Mar 11 00:00:00 EST 2021

Dimethyl Fumarate, an Approved Multiple Sclerosis Treatment, Reduces Brain Oxidative Stress in SIV-Infected Rhesus Macaques: Potential Therapeutic Repurposing for HIV Neuroprotection.

Antioxidants (Basel, Switzerland)

Garcia-Mesa Y,Xu HN,Vance P,Gruenewald AL,Garza R,Midkiff C,Alvarez-Hernandez X,Irwin DJ,Gill AJ,Kolson DL

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Immunohistochemistry

Tue Mar 09 00:00:00 EST 2021

Transplantation of human amniotic epithelial cells promotes morphological and functional regeneration in a rat uterine scar model.

Stem cell research & therapy

Fan Y,Sun J,Zhang Q,Lai D

11-9956 was used in Flow cytometry/Cell sorting to suggest that hAEC transplantation may be efficacious in the functional repair and collagen degradation of uterine scars, which provides a new therapeutic strategy to CSD.

Wed Mar 24 00:00:00 EDT 2021

Transplantation of human amniotic epithelial cells promotes morphological and functional regeneration in a rat uterine scar model.

Stem cell research & therapy

Fan Y,Sun J,Zhang Q,Lai D

Wed Mar 24 00:00:00 EDT 2021

Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation.

The Journal of clinical investigation

McArthur S,Juban G,Gobbetti T,Desgeorges T,Theret M,Gondin J,Toller-Kawahisa JE,Reutelingsperger CP,Chazaud B,Perretti M,Mounier R

11-9956 was used in Flow cytometry/Cell sorting to explore the role of Annexin A1 in skeletal muscle injury regeneration.

Mon Mar 02 00:00:00 EST 2020

Lung transplantation for patients with severe COVID-19.

Science translational medicine

Bharat A,Querrey M,Markov NS,Kim S,Kurihara C,Garza-Castillon R,Manerikar A,Shilatifard A,Tomic R,Politanska Y,Abdala-Valencia H,Yeldandi AV,Lomasney JW,Misharin AV,Budinger GRS

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Flow Cytometry

Wed Dec 16 00:00:00 EST 2020

Gene expression network analyses during infection with virulent and avirulent Trypanosoma cruzi strains unveil a role for fibroblasts in neutrophil recruitment and activation.

PLoS pathogens

Oliveira AER,Pereira MCA,Belew AT,Ferreira LRP,Pereira LMN,Neves EGA,Nunes MDCP,Burleigh BA,Dutra WO,El-Sayed NM,Gazzinelli RT,Teixeira SMR

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Flow Cytometry

Sat Aug 01 00:00:00 EDT 2020

PF-127 hydrogel plus sodium ascorbyl phosphate improves Wharton's jelly mesenchymal stem cell-mediated skin wound healing in mice.

Stem cell research & therapy

Deng Q,Huang S,Wen J,Jiao Y,Su X,Shi G,Huang J

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Flow Cytometry

Fri Apr 03 00:00:00 EDT 2020

PF-127 hydrogel plus sodium ascorbyl phosphate improves Wharton's jelly mesenchymal stem cell-mediated skin wound healing in mice.

Stem cell research & therapy

Deng Q,Huang S,Wen J,Jiao Y,Su X,Shi G,Huang J

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Flow Cytometry

Fri Apr 03 00:00:00 EDT 2020

Characterization of HLA-G Regulation and HLA Expression in Breast Cancer and Malignant Melanoma Cell Lines upon IFN-γ Stimulation and Inhibition of DNA Methylation.

International journal of molecular sciences

Jørgensen N,Sayed A,Jeppesen HB,Persson G,Weisdorf I,Funck T,Hviid TVF

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Flow Cytometry

Wed Jun 17 00:00:00 EDT 2020

Connecting METTL3 and intratumoural CD33⁺ MDSCs in predicting clinical outcome in cervical cancer.

Journal of translational medicine

Ni HH,Zhang L,Huang H,Dai SQ,Li J

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Flow Cytometry

Thu Oct 15 00:00:00 EDT 2020

New GMP manufacturing processes to obtain thermostable HIV-1 gp41 virosomes under solid forms for various mucosal vaccination routes.

NPJ vaccines

Amacker M,Smardon C,Mason L,Sorrell J,Jeffery K,Adler M,Bhoelan F,Belova O,Spengler M,Punnamoottil B,Schwaller M,Bonduelle O,Combadière B,Stegmann T,Naylor A,Johnson R,Wong D,Fleury S

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Flow Cytometry

Fri Dec 17 00:00:00 EST 2021

Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.

Nature communications

McQuade A,Kang YJ,Hasselmann J,Jairaman A,Sotelo A,Coburn M,Shabestari SK,Chadarevian JP,Fote G,Tu CH,Danhash E,Silva J,Martinez E,Cotman C,Prieto GA,Thompson LM,Steffan JS,Smith I,Davtyan H,Cahalan M,Cho H,Blurton-Jones M

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Immunohistochemistry

Fri Oct 23 00:00:00 EDT 2020

Aquaporin-4 Expression during Toxic and Autoimmune Demyelination.

Cells

Rohr SO,Greiner T,Joost S,Amor S,Valk PV,Schmitz C,Kipp M

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Immunohistochemistry

Mon Sep 28 00:00:00 EDT 2020

Tracking of epigenetic changes during hematopoietic differentiation of induced pluripotent stem cells.

Clinical epigenetics

Cypris O,Frobel J,Rai S,Franzen J,Sontag S,Goetzke R,Szymanski de Toledo MA,Zenke M,Wagner W

11-9956-42 was used in Flow Cytometry to compare genome-wide DNA methylation (DNAm) patterns of iHPCs with various different hematopoietic subsets.

Mon Feb 04 00:00:00 EST 2019

High-yield isolation of menstrual blood-derived endometrial stem cells by direct red blood cell lysis treatment.

Biology open

Sun Y,Ren Y,Yang F,He Y,Liang S,Guan L,Cheng F,Liu Y,Lin J

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Flow Cytometry

Thu May 02 00:00:00 EDT 2019

High-yield isolation of menstrual blood-derived endometrial stem cells by direct red blood cell lysis treatment.

Biology open

Sun Y,Ren Y,Yang F,He Y,Liang S,Guan L,Cheng F,Liu Y,Lin J

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Flow Cytometry

Thu May 02 00:00:00 EDT 2019

Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation.

Nature communications

Esfahani K,Al-Aubodah TA,Thebault P,Lapointe R,Hudson M,Johnson NA,Baran D,Bhulaiga N,Takano T,Cailhier JF,Piccirillo CA,Miller WH

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Flow Cytometry

Thu Oct 17 00:00:00 EDT 2019

Innate Lymphoid Cells Have Decreased HLA-DR Expression but Retain Their Responsiveness to TLR Ligands during Sepsis.

Journal of immunology (Baltimore, Md. : 1950)

Cruz-Zárate D,Cabrera-Rivera GL,Ruiz-Sánchez BP,Serafín-López J,Chacón-Salinas R,López-Macías C,Isibasi A,Gallegos-Pérez H,León-Gutiérrez MA,Ferat-Osorio E,Arriaga-Pizano L,Estrada-García I,Wong-Baeza I

11-9956 was used in Flow cytometry/Cell sorting to indicate that during sepsis, innate lymphoid cells have decreased HLA-DR expression and die via apoptosis, similar to monocytes and T cells.

Sat Dec 01 00:00:00 EST 2018

Isolation and characterization of stem cells from differentially degenerated human lumbar zygapophyseal articular cartilage.

Molecular medicine reports

Xiao L,Xu S,Wang X,Jin Z,Wang J,Yang B,Xu H

11-9956 was used in Flow cytometry/Cell sorting to show stem cells with multilineage differentiation potential and clonal properties were identified in human LZAC, and these characteristics were more prominent in mildly degenerated as compared with severely degenerated articular cartilage.

Sat Dec 01 00:00:00 EST 2018

Comprehensive characterization of chorionic villi-derived mesenchymal stromal cells from human placenta.

Stem cell research & therapy

Ventura Ferreira MS,Bienert M,Müller K,Rath B,Goecke T,Opländer C,Braunschweig T,Mela P,Brümmendorf TH,Beier F,Neuss S

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Flow Cytometry

Mon Feb 05 00:00:00 EST 2018

Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity.

Cell reports

Balan S,Arnold-Schrauf C,Abbas A,Couespel N,Savoret J,Imperatore F,Villani AC,Vu Manh TP,Bhardwaj N,Dalod M

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Flow Cytometry

Tue Aug 14 00:00:00 EDT 2018

Exosomes secreted by adipose-derived mesenchymal stem cells regulate type I collagen metabolism in fibroblasts from women with stress urinary incontinence.

Stem cell research & therapy

Liu X,Wang S,Wu S,Hao Q,Li Y,Guo Z,Wang W

Wed Jun 13 00:00:00 EDT 2018

Increased White Matter Inflammation in Aging- and Alzheimer's Disease Brain.

Frontiers in molecular neuroscience

Raj D,Yin Z,Breur M,Doorduin J,Holtman IR,Olah M,Mantingh-Otter IJ,Van Dam D,De Deyn PP,den Dunnen W,Eggen BJL,Amor S,Boddeke E

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Immunohistochemistry

Thu Oct 01 00:00:00 EDT 2020

Modelling IRF8 Deficient Human Hematopoiesis and Dendritic Cell Development with Engineered iPS Cells.

Stem cells (Dayton, Ohio)

Sontag S,Förster M,Qin J,Wanek P,Mitzka S,Schüler HM,Koschmieder S,Rose-John S,Seré K,Zenke M

11-9956 was used in Flow cytometry/Cell sorting to engineer a human IRF8 knockout model that allows studying molecular mechanisms of human immunodeficiencies in vitro, including the pathophysiology of IRF8 deficient DC.

Sat Apr 01 00:00:00 EDT 2017

HDAC inhibition potentiates immunotherapy in triple negative breast cancer.

Oncotarget

Terranova-Barberio M,Thomas S,Ali N,Pawlowska N,Park J,Krings G,Rosenblum MD,Budillon A,Munster PN

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Flow Cytometry

Tue Dec 26 00:00:00 EST 2017

Gut-homing Δ42PD1⁺Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection.

Nature microbiology

Cheung AKL,Kwok HY,Huang Y,Chen M,Mo Y,Wu X,Lam KS,Kong HK,Lau TCK,Zhou J,Li J,Cheng L,Kiat Lee B,Peng Q,Lu X,An M,Wang H,Shang H,Zhou B,Wu H,Xu A,Yuen KY,Chen Z

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Flow Cytometry

Sun Oct 01 00:00:00 EDT 2017

Surrogate in vitro activation of innate immunity synergizes with interleukin-7 to unleash rapid antigen-driven outgrowth of CD4+ and CD8+ human peripheral blood T-cells naturally recognizing MUC1, HER2/neu and other tumor-associated antigens.

Oncotarget

Pathangey LB,McCurry DB,Gendler SJ,Dominguez AL,Gorman JE,Pathangey G,Mihalik LA,Dang Y,Disis ML,Cohen PA

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Flow Cytometry

Tue Feb 14 00:00:00 EST 2017

Pathological manifestations in lymphatic filariasis correlate with lack of inhibitory properties of IgG4 antibodies on IgE-activated granulocytes.

PLoS neglected tropical diseases

Prodjinotho UF,von Horn C,Debrah AY,Batsa Debrah L,Albers A,Layland LE,Hoerauf A,Adjobimey T

11-9956 was used in Flow cytometry/Cell sorting to suggest that alterations in IgG4 antibodies are associated with the different clinical phenotypes in lymphatic filariasis endemic regions.

Sat Jul 01 00:00:00 EDT 2017

FOXP1 suppresses immune response signatures and MHC class II expression in activated B-cell-like diffuse large B-cell lymphomas.

Leukemia

Brown PJ,Wong KK,Felce SL,Lyne L,Spearman H,Soilleux EJ,Pedersen LM,Møller MB,Green TM,Gascoyne DM,Banham AH

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Flow Cytometry

Tue Mar 01 00:00:00 EST 2016

Lack of T Cell Response to iPSC-Derived Retinal Pigment Epithelial Cells from HLA Homozygous Donors.

Stem cell reports

Sugita S,Iwasaki Y,Makabe K,Kimura T,Futagami T,Suegami S,Takahashi M

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in ELISA

Tue Oct 11 00:00:00 EDT 2016

Lack of T Cell Response to iPSC-Derived Retinal Pigment Epithelial Cells from HLA Homozygous Donors.

Stem cell reports

Sugita S,Iwasaki Y,Makabe K,Kimura T,Futagami T,Suegami S,Takahashi M

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in ELISA

Tue Oct 11 00:00:00 EDT 2016

MIF Plays a Key Role in Regulating Tissue-Specific Chondro-Osteogenic Differentiation Fate of Human Cartilage Endplate Stem Cells under Hypoxia.

Stem cell reports

Yao Y,Deng Q,Song W,Zhang H,Li Y,Yang Y,Fan X,Liu M,Shang J,Sun C,Tang Y,Jin X,Liu H,Huang B,Zhou Y

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Flow Cytometry

Tue Aug 09 00:00:00 EDT 2016

Pentraxin-3 regulates the inflammatory activity of macrophages.

Biochemistry and biophysics reports

Shiraki A,Kotooka N,Komoda H,Hirase T,Oyama JI,Node K

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Immunocytochemistry

Tue Mar 01 00:00:00 EST 2016

Pentraxin-3 regulates the inflammatory activity of macrophages.

Biochemistry and biophysics reports

Shiraki A,Kotooka N,Komoda H,Hirase T,Oyama JI,Node K

Published figure using HLA-DR monoclonal antibody (Product # 11-9956-42) in Immunocytochemistry

Tue Mar 01 00:00:00 EST 2016

Leptin up-regulates TLR2 in human monocytes.

Journal of leukocyte biology

Jaedicke KM,Roythorne A,Padget K,Todryk S,Preshaw PM,Taylor JJ

11-9956 was used in Flow cytometry/Cell sorting to elucidate the effect of leptin on PRRs.

Mon Apr 01 00:00:00 EDT 2013

DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues.

Blood

Poulin LF,Reyal Y,Uronen-Hansson H,Schraml BU,Sancho D,Murphy KM,Håkansson UK,Moita LF,Agace WW,Bonnet D,Reis e Sousa C

11-9956 was used in Immunohistochemistry to investigate the presence of unique markers in human dendritic cells, showing that DNGR-1 is a specific marker of mouse and human dendritic cells in lymphoid and nonlymphoid tissues.

Thu Jun 21 00:00:00 EDT 2012

Bioinformatics

Protein Aliases: CD74; CD74 antigen; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); CD74 molecule, major histocompatibility complex, class II invariant chain; DASS-397D15.1; DR beta-5; DR-9; DR2-beta-2; DR7; DR9; DRB1 transplantation antigen; Dw2; DW2.2/DR2.2; FLJ51114; FLJ75017; FLJ76359; gamma chain of class II antigens; histocompatibility antigen HLA-DR alpha; HLA class II histocompatibility antigen gamma chain; HLA class II histocompatibility antigen, DR alpha chain; HLA class II histocompatibility antigen, DR beta 3 chain; HLA class II histocompatibility antigen, DR beta 4 chain; HLA class II histocompatibility antigen, DR beta 5 chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DR-5 beta chain; HLA class II histocompatibility antigen, DRB1 beta chain; HLA class II histocompatibility antigen, DRB1-7 beta chain; HLA class II histocompatibility antigen, DRB1-9 beta chain; HLA-DR antigens-associated invariant chain; HLA-DR-gamma; HLA-DRB1; HLA-DRB5; human leucocyte antigen DRB1; human leucocyte antigen DRB3; human leucocyte antigen DRB4; human leucocyte antigen DRB5; Human leukocyte antigen DRB1; Ia antigen-associated invariant chain; Ia-associated invariant chain; Ii; leukocyte antigen; leukocyte antigen class II; lymphocyte antigen DRB1; MHC cell surface glycoprotein; MHC class I antigen; MHC Class II antigen; MHC class II antigen DR beta 3 chain; MHC class II antigen DRA; MHC class II antigen DRB1*9; MHC class II antigen DRB3; MHC class II antigen DRB4; MHC class II antigen DRB5; MHC class II antigen HLA-DR-beta; MHC class II HLA beta chain; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR beta 3 chain; MHC class II HLA-DR-beta cell surface glycoprotein; MHC class II HLA-DRw10-beta; MHC class2 antigen; MHC HLA DR-beta chain; MHC HLA-DR gamma chain; MHC HLA-DR-beta cell surface glycoprotein; MHC HLA-DR-beta chain; p33; XXbac-BPG161M6.1

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Gene Aliases: CD74; DHLAG; DR-4; DR4; DRB1; DRB4; DRw10; HLA-DR1B; HLA-DR3B; HLA-DR4B; HLA-DRA; HLA-DRA1; HLA-DRB; HLA-DRB1; HLA-DRB3; HLA-DRB4; HLA-DRB5; HLADG; Ia-GAMMA; II; MLRW; SS1

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UniProt ID: (Human) P04233, (Human) P01903, (Human) Q5UBA2, (Human) P79483, (Human) P13762, (Human) Q30154

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Entrez Gene ID: (Human) 972, (Human) 3122, (Human) 3123, (Human) 3125, (Human) 3126, (Human) 3127

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Function(s)

beta-amyloid binding cytokine receptor activity protein binding cytokine binding MHC class II protein complex binding macrophage migration inhibitory factor binding MHC class II protein binding MHC class II protein binding, via antigen binding groove identical protein binding protein binding involved in protein folding nitric-oxide synthase binding MHC class II receptor activity peptide antigen binding major histocompatibility complex protein scaffold/adaptor protein

Process(es)

activation of MAPK activity prostaglandin biosynthetic process positive regulation of cytokine-mediated signaling pathway positive regulation of dendritic cell antigen processing and presentation negative regulation of peptide secretion positive regulation of type 2 immune response negative regulation of mature B cell apoptotic process protein complex assembly intracellular protein transport defense response signal transduction cell proliferation immunoglobulin mediated immune response antigen processing and presentation of endogenous antigen antigen processing and presentation of exogenous peptide antigen via MHC class II positive regulation of B cell proliferation macrophage migration inhibitory factor signaling pathway regulation of macrophage activation negative regulation of apoptotic process negative regulation of DNA damage response, signal transduction by p53 class mediator T cell selection positive thymic T cell selection negative thymic T cell selection negative regulation of T cell differentiation positive regulation of T cell differentiation positive regulation of fibroblast proliferation positive regulation of peptidyl-tyrosine phosphorylation leukocyte migration chaperone mediated protein folding requiring cofactor positive regulation of macrophage cytokine production positive regulation of ERK1 and ERK2 cascade positive regulation of neutrophil chemotaxis negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of chemokine (C-X-C motif) ligand 2 production peptide antigen assembly with MHC class II protein complex antigen processing and presentation of peptide or polysaccharide antigen via MHC class II polysaccharide assembly with MHC class II protein complex immune response viral process T cell costimulation T cell receptor signaling pathway cognition interferon-gamma-mediated signaling pathway

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HLA-DR Monoclonal Antibody (LN3), FITC, eBioscience™

HLA-DR Antibody (11-9956-42) in Flow

Product Details

11-9956-42

Immunohistochemistry (IHC)

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

ELISA (ELISA)

Species Reactivity

Published species

Host/Isotype

Recommended Isotype Control

Class

Type

Clone

Conjugate

Excitation/Emission Max

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

How to use the Panel Builder

Bioinformatics

Performance Guarantee

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