Invitrogen

HLA-DR Monoclonal Antibody (LN3), PE, eBioscience™

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

25 Published Figures

36 References

View all (121) HLA-DR antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

HLA-DR Antibody in Flow Cytometry (Flow)

FIGURE: 1 / 27

HLA-DR Antibody (12-9956-42) in Flow

Staining of normal human peripheral blood cells with Mouse IgG2b K Isotype Control PE (Product # 12-4732-81) (blue histogram) or Anti-Human HLA-DR PE (purple histogram). Cells in the lymphocyte (left) or monocyte (right) gate were used for analysis.

Product Image Gallery

Product Details

12-9956-42

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Flow Cytometry (Flow)

5 µL (0.007 µg)/test

View 35 publications 35 publications

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Mouse / IgG2b, kappa

Recommended Isotype Control

Mouse IgG2b kappa Isotype Control (eBMG2b), PE, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

LN3

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra

Form

Liquid

Concentration

5 µL/Test

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with 0.2% BSA

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10698015

Product Specific Information

Description: The LN3 mAb reacts with the human major histocompatibility complex (MHC) class II, HLA-DR. HLA-DR is expressed on the surface of human antigen presenting cells (APC) including B cells, monocytes, macrophages, DCs, and activated T cells. HLA-DR is a heterodimeric transmembrane protein composed of alpha and beta subunits and plays an important role in the presentation of peptides to CD4^+ T lymphocytes.

Applications Reported: The LN3 antibody has been reported for use in flow cytometric analysis.

Applications Tested: The LN3 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.007 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.

Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

Product References

TNF-α activates RELA expression via TNFRSF1B to upregulate OPA1 expression and inhibit chondrogenic differentiation of human adipose stem cells.

Journal of orthopaedic surgery and research

Guo J,Ye W,Wu X,Huang H,Li B,Sun Z,Ren Z,Yang Z

12-9956-42 was used in Flow cytometry/Cell sorting to show that the presence of TNF-α led to increased expression of TNFα receptor 2 (TNFRSF1B) and RELA during chondrogenic differentiation of hADSCs.

Tue Jun 13 00:00:00 EDT 2023

WT1 Pulsed Human CD141+ Dendritic Cell Vaccine Has High Potential in Solid Tumor-Targeted Immunotherapy.

International journal of molecular sciences

Cho SY,Jeong SM,Jeon YJ,Yang SJ,Hwang JE,Yoo BM,Kim HS

12-9956-42 was used in Flow cytometry/Cell sorting to develop a DC vaccine named CellgramDC-WT1 (CDW).

Thu Jan 12 00:00:00 EST 2023

Coordinated glucocorticoid receptor and MAFB action induces tolerogenesis and epigenome remodeling in dendritic cells.

Nucleic acids research

Morante-Palacios O,Ciudad L,Micheroli R,de la Calle-Fabregat C,Li T,Barbisan G,Houtman M,Edalat SG,Frank-Bertoncelj M,Ospelt C,Ballestar E

12-9956-42 was used in Flow cytometry/Cell sorting to investigate epigenetic and transcriptomic changes implicated with dendritic cell differentiation with glucocorticoids.

Tue Jan 11 00:00:00 EST 2022

Endothelial dysfunction markers and immune response indices in cosmonauts' blood after long-duration space flights.

NPJ microgravity

Kuzichkin DS,Nichiporuk IA,Zhuravleva OA,Markin AA,Rykova MP,Zhuravleva TV,Sadova AA,Kutko OV,Shmarov VA,Ponomarev SA

12-9956-42 was used in Flow cytometry/Cell sorting to investigat the markers of endothelial activation and damage (plasma concentrations of soluble thrombomodulin fraction (sTM), von Willebrand factor (vWF), highly sensitive C-reactive protein (hs-CRP)), as well as the level of D-dimer and compared them to the immunological parameters characterizing the state of human humoral and cellular immunity.

Wed Nov 02 00:00:00 EDT 2022

Activated CD4⁺ T cells and CD14^hiCD16⁺ monocytes correlate with antibody response following influenza virus infection in humans.

Cell reports. Medicine

Wong SS,Oshansky CM,Guo XJ,Ralston J,Wood T,Reynolds GE,Seeds R,Jelley L,Waite B,Jeevan T,Zanin M,Widdowson MA,Huang QS,Thomas PG,Webby RJ

Published figure using HLA-DR monoclonal antibody (Product # 12-9956-42) in Flow Cytometry

Tue Apr 20 00:00:00 EDT 2021

The role of irreversible electroporation in promoting M1 macrophage polarization via regulating the HMGB1-RAGE-MAPK axis in pancreatic cancer.

Oncoimmunology

He C,Sun S,Zhang Y,Xie F,Li S

Published figure using HLA-DR monoclonal antibody (Product # 12-9956-42) in Flow Cytometry

Thu Mar 11 00:00:00 EST 2021

Transplantation of human amniotic epithelial cells promotes morphological and functional regeneration in a rat uterine scar model.

Stem cell research & therapy

Fan Y,Sun J,Zhang Q,Lai D

Published figure using HLA-DR monoclonal antibody (Product # 12-9956-42) in Flow Cytometry

Wed Mar 24 00:00:00 EDT 2021

Lung transplantation for patients with severe COVID-19.

Science translational medicine

Bharat A,Querrey M,Markov NS,Kim S,Kurihara C,Garza-Castillon R,Manerikar A,Shilatifard A,Tomic R,Politanska Y,Abdala-Valencia H,Yeldandi AV,Lomasney JW,Misharin AV,Budinger GRS

Published figure using HLA-DR monoclonal antibody (Product # 12-9956-42) in Flow Cytometry

Wed Dec 16 00:00:00 EST 2020

Gene expression network analyses during infection with virulent and avirulent Trypanosoma cruzi strains unveil a role for fibroblasts in neutrophil recruitment and activation.

PLoS pathogens

Oliveira AER,Pereira MCA,Belew AT,Ferreira LRP,Pereira LMN,Neves EGA,Nunes MDCP,Burleigh BA,Dutra WO,El-Sayed NM,Gazzinelli RT,Teixeira SMR

Published figure using HLA-DR monoclonal antibody (Product # 12-9956-42) in Flow Cytometry

Sat Aug 01 00:00:00 EDT 2020

PF-127 hydrogel plus sodium ascorbyl phosphate improves Wharton's jelly mesenchymal stem cell-mediated skin wound healing in mice.

Stem cell research & therapy

Deng Q,Huang S,Wen J,Jiao Y,Su X,Shi G,Huang J

Published figure using HLA-DR monoclonal antibody (Product # 12-9956-42) in Flow Cytometry

Fri Apr 03 00:00:00 EDT 2020

Characterization of HLA-G Regulation and HLA Expression in Breast Cancer and Malignant Melanoma Cell Lines upon IFN-γ Stimulation and Inhibition of DNA Methylation.

International journal of molecular sciences

Jørgensen N,Sayed A,Jeppesen HB,Persson G,Weisdorf I,Funck T,Hviid TVF

Published figure using HLA-DR monoclonal antibody (Product # 12-9956-42) in Flow Cytometry

Wed Jun 17 00:00:00 EDT 2020

Connecting METTL3 and intratumoural CD33⁺ MDSCs in predicting clinical outcome in cervical cancer.

Journal of translational medicine

Ni HH,Zhang L,Huang H,Dai SQ,Li J

Published figure using HLA-DR monoclonal antibody (Product # 12-9956-42) in Flow Cytometry

Thu Oct 15 00:00:00 EDT 2020

New GMP manufacturing processes to obtain thermostable HIV-1 gp41 virosomes under solid forms for various mucosal vaccination routes.

NPJ vaccines

Amacker M,Smardon C,Mason L,Sorrell J,Jeffery K,Adler M,Bhoelan F,Belova O,Spengler M,Punnamoottil B,Schwaller M,Bonduelle O,Combadière B,Stegmann T,Naylor A,Johnson R,Wong D,Fleury S

Published figure using HLA-DR monoclonal antibody (Product # 12-9956-42) in Flow Cytometry

Fri Dec 17 00:00:00 EST 2021

Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation.

Nature communications

Esfahani K,Al-Aubodah TA,Thebault P,Lapointe R,Hudson M,Johnson NA,Baran D,Bhulaiga N,Takano T,Cailhier JF,Piccirillo CA,Miller WH

Published figure using HLA-DR monoclonal antibody (Product # 12-9956-42) in Flow Cytometry

Thu Oct 17 00:00:00 EDT 2019

STAT3 Inhibition Combined with CpG Immunostimulation Activates Antitumor Immunity to Eradicate Genetically Distinct Castration-Resistant Prostate Cancers.

Clinical cancer research : an official journal of the American Association for Cancer Research

Moreira D,Adamus T,Zhao X,Su YL,Zhang Z,White SV,Swiderski P,Lu X,DePinho RA,Pal SK,Kortylewski M

12-9956 was used in Flow cytometry/Cell sorting to show a novel strategy combining STAT3 inhibition with Toll-like Receptor 9 (TLR9) stimulation to unleash immune response against prostate cancers regardless of the genetic background.

Sat Dec 01 00:00:00 EST 2018

Comprehensive characterization of chorionic villi-derived mesenchymal stromal cells from human placenta.

Stem cell research & therapy

Ventura Ferreira MS,Bienert M,Müller K,Rath B,Goecke T,Opländer C,Braunschweig T,Mela P,Brümmendorf TH,Beier F,Neuss S

Published figure using HLA-DR monoclonal antibody (Product # 12-9956-42) in Flow Cytometry

Mon Feb 05 00:00:00 EST 2018

Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity.

Cell reports

Balan S,Arnold-Schrauf C,Abbas A,Couespel N,Savoret J,Imperatore F,Villani AC,Vu Manh TP,Bhardwaj N,Dalod M

Published figure using HLA-DR monoclonal antibody (Product # 12-9956-42) in Flow Cytometry

Tue Aug 14 00:00:00 EDT 2018

HDAC inhibition potentiates immunotherapy in triple negative breast cancer.

Oncotarget

Terranova-Barberio M,Thomas S,Ali N,Pawlowska N,Park J,Krings G,Rosenblum MD,Budillon A,Munster PN

Published figure using HLA-DR monoclonal antibody (Product # 12-9956-42) in Flow Cytometry

Tue Dec 26 00:00:00 EST 2017

Gut-homing Δ42PD1⁺Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection.

Nature microbiology

Cheung AKL,Kwok HY,Huang Y,Chen M,Mo Y,Wu X,Lam KS,Kong HK,Lau TCK,Zhou J,Li J,Cheng L,Kiat Lee B,Peng Q,Lu X,An M,Wang H,Shang H,Zhou B,Wu H,Xu A,Yuen KY,Chen Z

Published figure using HLA-DR monoclonal antibody (Product # 12-9956-42) in Flow Cytometry

Sun Oct 01 00:00:00 EDT 2017

Surrogate in vitro activation of innate immunity synergizes with interleukin-7 to unleash rapid antigen-driven outgrowth of CD4+ and CD8+ human peripheral blood T-cells naturally recognizing MUC1, HER2/neu and other tumor-associated antigens.

Oncotarget

Pathangey LB,McCurry DB,Gendler SJ,Dominguez AL,Gorman JE,Pathangey G,Mihalik LA,Dang Y,Disis ML,Cohen PA

Tue Feb 14 00:00:00 EST 2017

Allostimulatory capacity of conditionally immortalized proximal tubule cell lines for bioartificial kidney application.

Scientific reports

Mihajlovic M,van den Heuvel LP,Hoenderop JG,Jansen J,Wilmer MJ,Westheim AJF,Allebes WA,Stamatialis D,Hilbrands LB,Masereeuw R

12-9956 was used in Flow cytometry/Cell sorting to assess the immunosafety of conditionally immortalized proximal tubule cell lines for use in bioartificial kidneys, specifically by investigating their allogeneic efects.

Wed Aug 02 00:00:00 EDT 2017

FOXP1 suppresses immune response signatures and MHC class II expression in activated B-cell-like diffuse large B-cell lymphomas.

Leukemia

Brown PJ,Wong KK,Felce SL,Lyne L,Spearman H,Soilleux EJ,Pedersen LM,Møller MB,Green TM,Gascoyne DM,Banham AH

12-9956 was used in Flow cytometry/Cell sorting to identify FOXP1 as a novel regulator of genes targeted by the class II MHC transactivator CIITA.

Tue Mar 01 00:00:00 EST 2016

Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse.

The Journal of cell biology

Murugesan S,Hong J,Yi J,Li D,Beach JR,Shao L,Meinhardt J,Madison G,Wu X,Betzig E,Hammer JA

12-9956 was used in Flow cytometry/Cell sorting to reveal the derivation and organisation of actin arcs in the immunological synapse.

Mon Nov 07 00:00:00 EST 2016

Lack of T Cell Response to iPSC-Derived Retinal Pigment Epithelial Cells from HLA Homozygous Donors.

Stem cell reports

Sugita S,Iwasaki Y,Makabe K,Kimura T,Futagami T,Suegami S,Takahashi M

Published figure using HLA-DR monoclonal antibody (Product # 12-9956-42) in Flow Cytometry

Tue Oct 11 00:00:00 EDT 2016

MIF Plays a Key Role in Regulating Tissue-Specific Chondro-Osteogenic Differentiation Fate of Human Cartilage Endplate Stem Cells under Hypoxia.

Stem cell reports

Yao Y,Deng Q,Song W,Zhang H,Li Y,Yang Y,Fan X,Liu M,Shang J,Sun C,Tang Y,Jin X,Liu H,Huang B,Zhou Y

Published figure using HLA-DR monoclonal antibody (Product # 12-9956-42) in Flow Cytometry

Tue Aug 09 00:00:00 EDT 2016

Pentraxin-3 regulates the inflammatory activity of macrophages.

Biochemistry and biophysics reports

Shiraki A,Kotooka N,Komoda H,Hirase T,Oyama JI,Node K

12-9956 was used in Immunocytochemistry to investigate the function of pentraxin-3 in macrophages in vitro.

Tue Mar 01 00:00:00 EST 2016

CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22.

The Journal of experimental medicine

Longman RS,Diehl GE,Victorio DA,Huh JR,Galan C,Miraldi ER,Swaminath A,Bonneau R,Scherl EJ,Littman DR

12-9956 was used in Flow cytometry/Cell sorting to study the role of CX3CR1+ mononuclear phagocytes in the development of colitis and disease progression following Citrobacter rodentium infection.

Mon Jul 28 00:00:00 EDT 2014

The CD14+CD16+ inflammatory monocyte subset displays increased mitochondrial activity and effector function during acute Plasmodium vivax malaria.

PLoS pathogens

Antonelli LR,Leoratti FM,Costa PA,Rocha BC,Diniz SQ,Tada MS,Pereira DB,Teixeira-Carvalho A,Golenbock DT,Gonçalves R,Gazzinelli RT

12-9956 was used in Flow cytometry/Cell sorting to study inflammatory monocyte subsets displaying increased mitochondrial activity and effector function during malaria.

Mon Sep 01 00:00:00 EDT 2014

Incomplete normalization of regulatory t-cell frequency in the gut mucosa of Colombian HIV-infected patients receiving long-term antiretroviral treatment.

PloS one

Rueda CM,Velilla PA,Chougnet CA,Rugeles MT

12-9956 was used in Flow cytometry/Cell sorting to assess the frequency and phenotype of regulatory T-cells within CMV and HIV patients on different treatment regimes.

Tue Sep 23 00:00:00 EDT 2014

Stem cell microvesicles transfer cystinosin to human cystinotic cells and reduce cystine accumulation in vitro.

PloS one

Iglesias DM,El-Kares R,Taranta A,Bellomo F,Emma F,Besouw M,Levtchenko E,Toelen J,van den Heuvel L,Chu L,Zhao J,Young YK,Eliopoulos N,Goodyer P

12-9956 was used in Flow cytometry/Cell sorting to show that human mesenchymal stem cells, from amniotic fluid or bone marrow, reduce pathologic cystine accumulation in co-cultured CTNS mutant fibroblasts or proximal tubular cells from cystinosis patients.

Tue Apr 23 00:00:00 EDT 2013

HIV-induced T-cell activation/exhaustion in rectal mucosa is controlled only partially by antiretroviral treatment.

PloS one

Rueda CM,Velilla PA,Chougnet CA,Montoya CJ,Rugeles MT

12-9956 was used in Flow cytometry/Cell sorting to investigate the effect of chronic HIV infection on the immune cell phenotype.

Mon Jun 04 00:00:00 EDT 2012

Dendritic cells derived from hemozoin-loaded monocytes display a partial maturation phenotype that promotes HIV-1 trans-infection of CD4+ T cells and virus replication.

Journal of immunology (Baltimore, Md. : 1950)

Diou J,Tardif MR,Barat C,Tremblay MJ

12-9956 was used in Flow cytometry/Cell sorting to investigate the effect of malarial pigment hemozoin on HIV-1 transmission, showing that hemozoid-loaded monocytes promote HIV-1 trans-infection and replication.

Mon Mar 15 00:00:00 EDT 2010

Down-regulation of MHC class II expression through inhibition of CIITA transcription by lytic transactivator Zta during Epstein-Barr virus reactivation.

Journal of immunology (Baltimore, Md. : 1950)

Li D,Qian L,Chen C,Shi M,Yu M,Hu M,Song L,Shen B,Guo N

12-9956 was used in Flow cytometry/Cell sorting to indicate that Zta may act as an inhibitor of the MHC class II pathway, suppressing CIITA transcription.

Sun Feb 15 00:00:00 EST 2009

Immunological aspects of REIC/Dkk-3 in monocyte differentiation and tumor regression.

International journal of oncology

Watanabe M,Kashiwakura Y,Huang P,Ochiai K,Futami J,Li SA,Takaoka M,Nasu Y,Sakaguchi M,Huh NH,Kumon H

12-9956-42 was used in Flow cytometry/Cell sorting to study that recombinant REIC/Dkk-3 protein induced the differentiation of human CD14+ monocytes into a novel cell type.

Sun Mar 01 00:00:00 EST 2009

A distinct Toll-like receptor repertoire in human tonsillar B cells, directly activated by PamCSK, R-837 and CpG-2006 stimulation.

Immunology

Månsson A,Adner M,Höckerfelt U,Cardell LO

12-9956 was used in Flow cytometry/Cell sorting to emphasize the unique ability of B cells to respond directly, via TLRs, to a certain range of microbial structures, further stressing the importance of TLRs in our defence against invading pathogens.

Tue Aug 01 00:00:00 EDT 2006

Expansion of toll-like receptor 9-expressing B cells in active systemic lupus erythematosus: implications for the induction and maintenance of the autoimmune process.

Arthritis and rheumatism

Papadimitraki ED,Choulaki C,Koutala E,Bertsias G,Tsatsanis C,Gergianaki I,Raptopoulou A,Kritikos HD,Mamalaki C,Sidiropoulos P,Boumpas DT

12-9956 was used in Flow cytometry/Cell sorting to examine the expression and function of various TLRs in subpopulations of peripheral blood mononuclear cells of patients with systemic lupus erythematosus.

Wed Nov 01 00:00:00 EST 2006

Bioinformatics

Protein Aliases: CD74; CD74 antigen; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); CD74 molecule, major histocompatibility complex, class II invariant chain; DASS-397D15.1; DR beta-5; DR-9; DR2-beta-2; DR7; DR9; DRB1 transplantation antigen; Dw2; DW2.2/DR2.2; FLJ51114; FLJ75017; FLJ76359; gamma chain of class II antigens; histocompatibility antigen HLA-DR alpha; HLA class II histocompatibility antigen gamma chain; HLA class II histocompatibility antigen, DR alpha chain; HLA class II histocompatibility antigen, DR beta 3 chain; HLA class II histocompatibility antigen, DR beta 4 chain; HLA class II histocompatibility antigen, DR beta 5 chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DR-5 beta chain; HLA class II histocompatibility antigen, DRB1 beta chain; HLA class II histocompatibility antigen, DRB1-7 beta chain; HLA class II histocompatibility antigen, DRB1-9 beta chain; HLA-DR antigens-associated invariant chain; HLA-DR-gamma; HLA-DRB1; HLA-DRB5; human leucocyte antigen DRB1; human leucocyte antigen DRB3; human leucocyte antigen DRB4; human leucocyte antigen DRB5; Human leukocyte antigen DRB1; Ia antigen-associated invariant chain; Ia-associated invariant chain; Ii; leukocyte antigen; leukocyte antigen class II; lymphocyte antigen DRB1; MHC cell surface glycoprotein; MHC class I antigen; MHC Class II antigen; MHC class II antigen DR beta 3 chain; MHC class II antigen DRA; MHC class II antigen DRB1*9; MHC class II antigen DRB3; MHC class II antigen DRB4; MHC class II antigen DRB5; MHC class II antigen HLA-DR-beta; MHC class II HLA beta chain; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR beta 3 chain; MHC class II HLA-DR-beta cell surface glycoprotein; MHC class II HLA-DRw10-beta; MHC class2 antigen; MHC HLA DR-beta chain; MHC HLA-DR gamma chain; MHC HLA-DR-beta cell surface glycoprotein; MHC HLA-DR-beta chain; p33; XXbac-BPG161M6.1

View more View less

Gene Aliases: CD74; DHLAG; DR-4; DR4; DRB1; DRB4; DRw10; HLA-DR1B; HLA-DR3B; HLA-DR4B; HLA-DRA; HLA-DRA1; HLA-DRB; HLA-DRB1; HLA-DRB3; HLA-DRB4; HLA-DRB5; HLADG; Ia-GAMMA; II; MLRW; SS1

View more View less

UniProt ID: (Human) P04233, (Human) P01903, (Human) Q5UBA2, (Human) P79483, (Human) P13762, (Human) Q30154

View more View less

Entrez Gene ID: (Human) 972, (Human) 3122, (Human) 3123, (Human) 3125, (Human) 3126, (Human) 3127

View more View less

Function(s)

beta-amyloid binding cytokine receptor activity protein binding cytokine binding MHC class II protein complex binding macrophage migration inhibitory factor binding MHC class II protein binding MHC class II protein binding, via antigen binding groove identical protein binding protein binding involved in protein folding nitric-oxide synthase binding MHC class II receptor activity peptide antigen binding major histocompatibility complex protein scaffold/adaptor protein

Process(es)

activation of MAPK activity prostaglandin biosynthetic process positive regulation of cytokine-mediated signaling pathway positive regulation of dendritic cell antigen processing and presentation negative regulation of peptide secretion positive regulation of type 2 immune response negative regulation of mature B cell apoptotic process protein complex assembly intracellular protein transport defense response signal transduction cell proliferation immunoglobulin mediated immune response antigen processing and presentation of endogenous antigen antigen processing and presentation of exogenous peptide antigen via MHC class II positive regulation of B cell proliferation macrophage migration inhibitory factor signaling pathway regulation of macrophage activation negative regulation of apoptotic process negative regulation of DNA damage response, signal transduction by p53 class mediator T cell selection positive thymic T cell selection negative thymic T cell selection negative regulation of T cell differentiation positive regulation of T cell differentiation positive regulation of fibroblast proliferation positive regulation of peptidyl-tyrosine phosphorylation leukocyte migration chaperone mediated protein folding requiring cofactor positive regulation of macrophage cytokine production positive regulation of ERK1 and ERK2 cascade positive regulation of neutrophil chemotaxis negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of chemokine (C-X-C motif) ligand 2 production peptide antigen assembly with MHC class II protein complex antigen processing and presentation of peptide or polysaccharide antigen via MHC class II polysaccharide assembly with MHC class II protein complex immune response viral process T cell costimulation T cell receptor signaling pathway cognition interferon-gamma-mediated signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

HLA-DR Monoclonal Antibody (LN3), PE, eBioscience™

HLA-DR Antibody (12-9956-42) in Flow

Product Details

12-9956-42

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Recommended Isotype Control

Class

Type

Clone

Conjugate

Excitation/Emission Max

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

How to use the Panel Builder

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!