Invitrogen

HLA-DR Monoclonal Antibody (LN3), APC, eBioscience™

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

25 Published Figures

38 References

View all (121) HLA-DR antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

HLA-DR Antibody in Flow Cytometry (Flow)

FIGURE: 1 / 27

HLA-DR Antibody (17-9956-42) in Flow

Staining of normal human peripheral blood cells with staining buffer (autofluorescence) (open histogram) or Anti-Human HLA-DR APC (filled histogram). Cells in the lymphocyte (left) or monocyte (right) gate were used for analysis.

Product Image Gallery

Product Details

17-9956-42

Applications

Tested Dilution

Publications

Western Blot (WB)

View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

View 1 publication 1 publication

Flow Cytometry (Flow)

5 µL (0.0075 µg)/test

View 36 publications 36 publications

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Mouse / IgG2b, kappa

Recommended Isotype Control

Mouse IgG2b kappa Isotype Control (eBMG2b), APC, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

LN3

Conjugate

APC APC APC

Excitation/Emission Max

651/660 nm View spectra

Form

Liquid

Concentration

5 µL/Test

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with 0.2% BSA

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10670347

Product Specific Information

Description: The LN3 mAb reacts with the human major histocompatibility complex (MHC) class II, HLA-DR. HLA-DR is expressed on the surface of human antigen presenting cells (APC) including B cells, monocytes, macrophages, DCs, and activated T cells. HLA-DR is a heterodimeric transmembrane protein composed of alpha and beta subunits and plays an important role in the presentation of peptides to CD4^+ T lymphocytes.

Applications Reported: The LN3 antibody has been reported for use in flow cytometric analysis.

Applications Tested: The LN3 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.0075 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.

Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter.

Acta neuropathologica communications

Miedema A,Gerrits E,Brouwer N,Jiang Q,Kracht L,Meijer M,Nutma E,Peferoen-Baert R,Pijnacker ATE,Wesseling EM,Wijering MHC,Gabius HJ,Amor S,Eggen BJL,Kooistra SM

17-9956-42 was used in Immunohistochemistry (Frozen) to characterize early changes in multiple sclerosis brain tissue, identifying specific microglia and macrophage subsets at different stages of demyelinating lesions.

Fri Jan 28 00:00:00 EST 2022

Activated CD4⁺ T cells and CD14^hiCD16⁺ monocytes correlate with antibody response following influenza virus infection in humans.

Cell reports. Medicine

Wong SS,Oshansky CM,Guo XJ,Ralston J,Wood T,Reynolds GE,Seeds R,Jelley L,Waite B,Jeevan T,Zanin M,Widdowson MA,Huang QS,Thomas PG,Webby RJ

Published figure using HLA-DR monoclonal antibody (Product # 17-9956-42) in Flow Cytometry

Tue Apr 20 00:00:00 EDT 2021

The role of irreversible electroporation in promoting M1 macrophage polarization via regulating the HMGB1-RAGE-MAPK axis in pancreatic cancer.

Oncoimmunology

He C,Sun S,Zhang Y,Xie F,Li S

Published figure using HLA-DR monoclonal antibody (Product # 17-9956-42) in Flow Cytometry

Thu Mar 11 00:00:00 EST 2021

Transplantation of human amniotic epithelial cells promotes morphological and functional regeneration in a rat uterine scar model.

Stem cell research & therapy

Fan Y,Sun J,Zhang Q,Lai D

Published figure using HLA-DR monoclonal antibody (Product # 17-9956-42) in Flow Cytometry

Wed Mar 24 00:00:00 EDT 2021

Lung transplantation for patients with severe COVID-19.

Science translational medicine

Bharat A,Querrey M,Markov NS,Kim S,Kurihara C,Garza-Castillon R,Manerikar A,Shilatifard A,Tomic R,Politanska Y,Abdala-Valencia H,Yeldandi AV,Lomasney JW,Misharin AV,Budinger GRS

Published figure using HLA-DR monoclonal antibody (Product # 17-9956-42) in Flow Cytometry

Wed Dec 16 00:00:00 EST 2020

Gene expression network analyses during infection with virulent and avirulent Trypanosoma cruzi strains unveil a role for fibroblasts in neutrophil recruitment and activation.

PLoS pathogens

Oliveira AER,Pereira MCA,Belew AT,Ferreira LRP,Pereira LMN,Neves EGA,Nunes MDCP,Burleigh BA,Dutra WO,El-Sayed NM,Gazzinelli RT,Teixeira SMR

Published figure using HLA-DR monoclonal antibody (Product # 17-9956-42) in Flow Cytometry

Sat Aug 01 00:00:00 EDT 2020

Cutting edge approaches for rapid characterization of airway exosomes.

Methods (San Diego, Calif.)

Hough KP,Deshane JS

17-9956 was used in Flow cytometry/Cell sorting to describe two methods of rapid exosomes characterization: (1) imaging flow cytometry using ImageStream; and (2) conventional flow cytometry using the BD Symphony A5 platform.

Fri May 01 00:00:00 EDT 2020

PF-127 hydrogel plus sodium ascorbyl phosphate improves Wharton's jelly mesenchymal stem cell-mediated skin wound healing in mice.

Stem cell research & therapy

Deng Q,Huang S,Wen J,Jiao Y,Su X,Shi G,Huang J

Published figure using HLA-DR monoclonal antibody (Product # 17-9956-42) in Flow Cytometry

Fri Apr 03 00:00:00 EDT 2020

Characterization of HLA-G Regulation and HLA Expression in Breast Cancer and Malignant Melanoma Cell Lines upon IFN-γ Stimulation and Inhibition of DNA Methylation.

International journal of molecular sciences

Jørgensen N,Sayed A,Jeppesen HB,Persson G,Weisdorf I,Funck T,Hviid TVF

Published figure using HLA-DR monoclonal antibody (Product # 17-9956-42) in Flow Cytometry

Wed Jun 17 00:00:00 EDT 2020

Connecting METTL3 and intratumoural CD33⁺ MDSCs in predicting clinical outcome in cervical cancer.

Journal of translational medicine

Ni HH,Zhang L,Huang H,Dai SQ,Li J

Published figure using HLA-DR monoclonal antibody (Product # 17-9956-42) in Flow Cytometry

Thu Oct 15 00:00:00 EDT 2020

Connecting METTL3 and intratumoural CD33⁺ MDSCs in predicting clinical outcome in cervical cancer.

Journal of translational medicine

Ni HH,Zhang L,Huang H,Dai SQ,Li J

Published figure using HLA-DR monoclonal antibody (Product # 17-9956-42) in Flow Cytometry

Thu Oct 15 00:00:00 EDT 2020

New GMP manufacturing processes to obtain thermostable HIV-1 gp41 virosomes under solid forms for various mucosal vaccination routes.

NPJ vaccines

Amacker M,Smardon C,Mason L,Sorrell J,Jeffery K,Adler M,Bhoelan F,Belova O,Spengler M,Punnamoottil B,Schwaller M,Bonduelle O,Combadière B,Stegmann T,Naylor A,Johnson R,Wong D,Fleury S

Published figure using HLA-DR monoclonal antibody (Product # 17-9956-42) in Flow Cytometry

Fri Dec 17 00:00:00 EST 2021

Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation.

Nature communications

Esfahani K,Al-Aubodah TA,Thebault P,Lapointe R,Hudson M,Johnson NA,Baran D,Bhulaiga N,Takano T,Cailhier JF,Piccirillo CA,Miller WH

Published figure using HLA-DR monoclonal antibody (Product # 17-9956-42) in Flow Cytometry

Thu Oct 17 00:00:00 EDT 2019

Long Non-Coding RNA HOXA Transcript Antisense RNA Myeloid-Specific 1-HOXA1 Axis Downregulates the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in Lung Cancer.

Frontiers in immunology

Tian X,Ma J,Wang T,Tian J,Zhang Y,Mao L,Xu H,Wang S

17-9956 was used in Flow cytometry/Cell sorting to conclude that HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) downregulates the immunosuppressive function of myeloid-derived suppressor cells by targeting HOXA1, providing a potential therapeutic target in lung cancer.

Mon Jun 24 00:00:00 EDT 2019

Downregulation of ROS1 enhances the therapeutic efficacy of arsenic trioxide in acute myeloid leukemia cell lines.

Oncology letters

Li J

17-9956-42 was used in Western Blot to investigate the function of ROS proto-oncogene 1 receptor tyrosine kinase in regulating the migration and proliferation of acute myeloid leukemia cells through Wnt/β-catenin signaling, and in arsenic trioxide treatment.

Fri Jun 01 00:00:00 EDT 2018

AG490 reverses phenotypic alteration of dendritic cells by bladder cancer cells.

Oncology letters

Xiu W,Ma J,Lei T,Zhang M

17-9956 was used in Flow cytometry/Cell sorting to study the ability of AG490 to partly reverse the inhibitory effect of bladder cancer cells on dendritic cells, and induce their anti-tumour immunity response.

Sat Sep 01 00:00:00 EDT 2018

Comprehensive characterization of chorionic villi-derived mesenchymal stromal cells from human placenta.

Stem cell research & therapy

Ventura Ferreira MS,Bienert M,Müller K,Rath B,Goecke T,Opländer C,Braunschweig T,Mela P,Brümmendorf TH,Beier F,Neuss S

Published figure using HLA-DR monoclonal antibody (Product # 17-9956-42) in Flow Cytometry

Mon Feb 05 00:00:00 EST 2018

Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity.

Cell reports

Balan S,Arnold-Schrauf C,Abbas A,Couespel N,Savoret J,Imperatore F,Villani AC,Vu Manh TP,Bhardwaj N,Dalod M

Published figure using HLA-DR monoclonal antibody (Product # 17-9956-42) in Flow Cytometry

Tue Aug 14 00:00:00 EDT 2018

NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification.

JCI insight

Barruet E,Morales BM,Cain CJ,Ton AN,Wentworth KL,Chan TV,Moody TA,Haks MC,Ottenhoff TH,Hellman J,Nakamura MC,Hsiao EC

17-9956 was used in Flow cytometry/Cell sorting to examine the potential link between bone morphogenetic proteins and inflammation in patients with fibrodysplasia ossificans progressiva.

Thu Nov 15 00:00:00 EST 2018

Exosomal transfer of mitochondria from airway myeloid-derived regulatory cells to T cells.

Redox biology

Hough KP,Trevor JL,Strenkowski JG,Wang Y,Chacko BK,Tousif S,Chanda D,Steele C,Antony VB,Dokland T,Ouyang X,Zhang J,Duncan SR,Thannickal VJ,Darley-Usmar VM,Deshane JS

Sat Sep 01 00:00:00 EDT 2018

Unique Lipid Signatures of Extracellular Vesicles from the Airways of Asthmatics.

Scientific reports

Hough KP,Wilson LS,Trevor JL,Strenkowski JG,Maina N,Kim YI,Spell ML,Wang Y,Chanda D,Dager JR,Sharma NS,Curtiss M,Antony VB,Dransfield MT,Chaplin DD,Steele C,Barnes S,Duncan SR,Prasain JK,Thannickal VJ,Deshane JS

17-9956 was used in Flow cytometry/Cell sorting to characterise the lipid composition of extracellular vesicless from asthmatics and healthy subjects, as well as secondhand smoke (SHS) exposed subjects from each group.

Mon Jul 09 00:00:00 EDT 2018

CD14^brightCD16+ intermediate monocytes are induced by interleukin-10 and positively correlate with disease activity in rheumatoid arthritis.

Arthritis research & therapy

Tsukamoto M,Seta N,Yoshimoto K,Suzuki K,Yamaoka K,Takeuchi T

17-9956 was used in Flow cytometry to investigate the association of CD14brightCD16+ monocytes with rheumatoid arthritis (RA).

Fri Feb 10 00:00:00 EST 2017

HDAC inhibition potentiates immunotherapy in triple negative breast cancer.

Oncotarget

Terranova-Barberio M,Thomas S,Ali N,Pawlowska N,Park J,Krings G,Rosenblum MD,Budillon A,Munster PN

Published figure using HLA-DR monoclonal antibody (Product # 17-9956-42) in Flow Cytometry

Tue Dec 26 00:00:00 EST 2017

Gut-homing Δ42PD1⁺Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection.

Nature microbiology

Cheung AKL,Kwok HY,Huang Y,Chen M,Mo Y,Wu X,Lam KS,Kong HK,Lau TCK,Zhou J,Li J,Cheng L,Kiat Lee B,Peng Q,Lu X,An M,Wang H,Shang H,Zhou B,Wu H,Xu A,Yuen KY,Chen Z

Published figure using HLA-DR monoclonal antibody (Product # 17-9956-42) in Flow Cytometry

Sun Oct 01 00:00:00 EDT 2017

Surrogate in vitro activation of innate immunity synergizes with interleukin-7 to unleash rapid antigen-driven outgrowth of CD4+ and CD8+ human peripheral blood T-cells naturally recognizing MUC1, HER2/neu and other tumor-associated antigens.

Oncotarget

Pathangey LB,McCurry DB,Gendler SJ,Dominguez AL,Gorman JE,Pathangey G,Mihalik LA,Dang Y,Disis ML,Cohen PA

Published figure using HLA-DR monoclonal antibody (Product # 17-9956-42) in Flow Cytometry

Tue Feb 14 00:00:00 EST 2017

FOXP1 suppresses immune response signatures and MHC class II expression in activated B-cell-like diffuse large B-cell lymphomas.

Leukemia

Brown PJ,Wong KK,Felce SL,Lyne L,Spearman H,Soilleux EJ,Pedersen LM,Møller MB,Green TM,Gascoyne DM,Banham AH

Published figure using HLA-DR monoclonal antibody (Product # 17-9956-42) in Flow Cytometry

Tue Mar 01 00:00:00 EST 2016

An in vitro model of granuloma-like cell aggregates substantiates early host immune responses against Mycobacterium massiliense infection.

Biology open

Je S,Quan H,Na Y,Cho SN,Kim BJ,Seok SH

17-9956 was used in Flow cytometry/Cell sorting to study the interaction between host cells and Mycobacterium massiliense.

Mon Aug 15 00:00:00 EDT 2016

Lack of T Cell Response to iPSC-Derived Retinal Pigment Epithelial Cells from HLA Homozygous Donors.

Stem cell reports

Sugita S,Iwasaki Y,Makabe K,Kimura T,Futagami T,Suegami S,Takahashi M

Published figure using HLA-DR monoclonal antibody (Product # 17-9956-42) in Flow Cytometry

Tue Oct 11 00:00:00 EDT 2016

MIF Plays a Key Role in Regulating Tissue-Specific Chondro-Osteogenic Differentiation Fate of Human Cartilage Endplate Stem Cells under Hypoxia.

Stem cell reports

Yao Y,Deng Q,Song W,Zhang H,Li Y,Yang Y,Fan X,Liu M,Shang J,Sun C,Tang Y,Jin X,Liu H,Huang B,Zhou Y

Published figure using HLA-DR monoclonal antibody (Product # 17-9956-42) in Flow Cytometry

Tue Aug 09 00:00:00 EDT 2016

Efficient gene disruption in cultured primary human endothelial cells by CRISPR/Cas9.

Circulation research

Abrahimi P,Chang WG,Kluger MS,Qyang Y,Tellides G,Saltzman WM,Pober JS

17-9956 was used in Flow cytometry/Cell sorting to demonstrate that the CRISPR/Cas9 modification of epithelial cells is a powerful platform for vascular research and for regenerative medicine.

Fri Jul 03 00:00:00 EDT 2015

Atypical and classical memory B cells produce Plasmodium falciparum neutralizing antibodies.

The Journal of experimental medicine

Muellenbeck MF,Ueberheide B,Amulic B,Epp A,Fenyo D,Busse CE,Esen M,Theisen M,Mordmüller B,Wardemann H

17-9956 was used in Flow cytometry/Cell sorting to show that Plasmodium falciparum (Pf) infection induces the development of memory B cells that produce antibodies against blood stage Pf parasites.

Mon Feb 11 00:00:00 EST 2013

Novel immunomodulators from hard ticks selectively reprogramme human dendritic cell responses.

PLoS pathogens

Preston SG,Majtán J,Kouremenou C,Rysnik O,Burger LF,Cabezas Cruz A,Chiong Guzman M,Nunn MA,Paesen GC,Nuttall PA,Austyn JM

17-9956 was used in Flow cytometry/Cell sorting to provide a previously unknown mechanism for parasite-induced subversion of adaptive immunity.

Fri Jan 17 00:00:00 EST 2014

Small molecule inhibitor of antigen binding and presentation by HLA-DR2b as a therapeutic strategy for the treatment of multiple sclerosis.

Journal of immunology (Baltimore, Md. : 1950)

Ji N,Somanaboeina A,Dixit A,Kawamura K,Hayward NJ,Self C,Olson GL,Forsthuber TG

17-9956 was used in Flow cytometry/Cell sorting to investigate how blocking the HLA-DR2b allele with small molecule inhibitors may offer a promising therapeutic strategy for the treatment of multiple sclerosis.

Fri Nov 15 00:00:00 EST 2013

Changes in the monocytic subsets CD14(dim)CD16(+) and CD14(++)CD16(-) in chronic systolic heart failure patients.

Mediators of inflammation

Amir O,Spivak I,Lavi I,Rahat MA

17-9956 was used in Flow cytometry/Cell sorting to characterise changes in the distribution of monocyte subsets in patients with chronic systolic heart failure and to explore the impact of these subsets on key inflammatory cytokines.

Mon Jul 29 00:00:00 EDT 2013

Haemophilus ducreyi-induced interleukin-10 promotes a mixed M1 and M2 activation program in human macrophages.

Infection and immunity

Li W,Katz BP,Spinola SM

17-9956 was used in Flow cytometry/Cell sorting to investigate the contribution of IL-10-modulated macrophage polarisation to H. ducreyi clearance during human infection.

Sat Dec 01 00:00:00 EST 2012

Alleviation of insulin resistance and liver damage by oral administration of Imm124-E is mediated by increased Tregs and associated with increased serum GLP-1 and adiponectin: results of a phase I/II clinical trial in NASH.

Journal of inflammation research

Mizrahi M,Shabat Y,Ben Ya'acov A,Lalazar G,Adar T,Wong V,Muller B,Rawlin G,Ilan Y

17-9956 was used in Flow cytometry/Cell sorting to examine the reported beneficial effects of Imm124-E for the treatment of organ damage.

Tue Jan 08 00:00:00 EST 2013

Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Nagata S,Ise T,Pastan I

17-9956 was used in Flow cytometry/Cell sorting to study the effects of Foxp3 and IL-2 on FCRL3-/+ nTreg cell subsets.

Mon Jun 15 00:00:00 EDT 2009

Linking innate and adaptive immunity: human Vgamma9Vdelta2 T cells enhance CD40 expression and HMGB-1 secretion.

Mediators of inflammation

Kalyan S,Chow AW

17-9956 was used in Flow cytometry/Cell sorting to show that gammadelta T cells induce an early upregulation of CD40 on monocytes and the local release of High Mobility Group Box-1.

Wed Dec 16 00:00:00 EST 2009

T regulatory cell levels decrease in people infected with Schistosoma mansoni on effective treatment.

The American journal of tropical medicine and hygiene

Watanabe K,Mwinzi PN,Black CL,Muok EM,Karanja DM,Secor WE,Colley DG

17-9956 was used in Flow cytometry/Cell sorting to investigate the role of Tregs in Schistosoma mansoni infection, showing that Treg levels decrease in people on effective treatment.

Mon Oct 01 00:00:00 EDT 2007

Bioinformatics

Protein Aliases: CD74; CD74 antigen; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); CD74 molecule, major histocompatibility complex, class II invariant chain; DASS-397D15.1; DR beta-5; DR-9; DR2-beta-2; DR7; DR9; DRB1 transplantation antigen; Dw2; DW2.2/DR2.2; FLJ51114; FLJ75017; FLJ76359; gamma chain of class II antigens; histocompatibility antigen HLA-DR alpha; HLA class II histocompatibility antigen gamma chain; HLA class II histocompatibility antigen, DR alpha chain; HLA class II histocompatibility antigen, DR beta 3 chain; HLA class II histocompatibility antigen, DR beta 4 chain; HLA class II histocompatibility antigen, DR beta 5 chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DR-5 beta chain; HLA class II histocompatibility antigen, DRB1 beta chain; HLA class II histocompatibility antigen, DRB1-7 beta chain; HLA class II histocompatibility antigen, DRB1-9 beta chain; HLA-DR antigens-associated invariant chain; HLA-DR-gamma; HLA-DRB1; HLA-DRB5; human leucocyte antigen DRB1; human leucocyte antigen DRB3; human leucocyte antigen DRB4; human leucocyte antigen DRB5; Human leukocyte antigen DRB1; Ia antigen-associated invariant chain; Ia-associated invariant chain; Ii; leukocyte antigen; leukocyte antigen class II; lymphocyte antigen DRB1; MHC cell surface glycoprotein; MHC class I antigen; MHC Class II antigen; MHC class II antigen DR beta 3 chain; MHC class II antigen DRA; MHC class II antigen DRB1*9; MHC class II antigen DRB3; MHC class II antigen DRB4; MHC class II antigen DRB5; MHC class II antigen HLA-DR-beta; MHC class II HLA beta chain; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR beta 3 chain; MHC class II HLA-DR-beta cell surface glycoprotein; MHC class II HLA-DRw10-beta; MHC class2 antigen; MHC HLA DR-beta chain; MHC HLA-DR gamma chain; MHC HLA-DR-beta cell surface glycoprotein; MHC HLA-DR-beta chain; p33; XXbac-BPG161M6.1

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Gene Aliases: CD74; DHLAG; DR-4; DR4; DRB1; DRB4; DRw10; HLA-DR1B; HLA-DR3B; HLA-DR4B; HLA-DRA; HLA-DRA1; HLA-DRB; HLA-DRB1; HLA-DRB3; HLA-DRB4; HLA-DRB5; HLADG; Ia-GAMMA; II; MLRW; SS1

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UniProt ID: (Human) P04233, (Human) P01903, (Human) Q5UBA2, (Human) P79483, (Human) P13762, (Human) Q30154

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Entrez Gene ID: (Human) 972, (Human) 3122, (Human) 3123, (Human) 3125, (Human) 3126, (Human) 3127

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Function(s)

beta-amyloid binding cytokine receptor activity protein binding cytokine binding MHC class II protein complex binding macrophage migration inhibitory factor binding MHC class II protein binding MHC class II protein binding, via antigen binding groove identical protein binding protein binding involved in protein folding nitric-oxide synthase binding MHC class II receptor activity peptide antigen binding major histocompatibility complex protein scaffold/adaptor protein

Process(es)

activation of MAPK activity prostaglandin biosynthetic process positive regulation of cytokine-mediated signaling pathway positive regulation of dendritic cell antigen processing and presentation negative regulation of peptide secretion positive regulation of type 2 immune response negative regulation of mature B cell apoptotic process protein complex assembly intracellular protein transport defense response signal transduction cell proliferation immunoglobulin mediated immune response antigen processing and presentation of endogenous antigen antigen processing and presentation of exogenous peptide antigen via MHC class II positive regulation of B cell proliferation macrophage migration inhibitory factor signaling pathway regulation of macrophage activation negative regulation of apoptotic process negative regulation of DNA damage response, signal transduction by p53 class mediator T cell selection positive thymic T cell selection negative thymic T cell selection negative regulation of T cell differentiation positive regulation of T cell differentiation positive regulation of fibroblast proliferation positive regulation of peptidyl-tyrosine phosphorylation leukocyte migration chaperone mediated protein folding requiring cofactor positive regulation of macrophage cytokine production positive regulation of ERK1 and ERK2 cascade positive regulation of neutrophil chemotaxis negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of chemokine (C-X-C motif) ligand 2 production peptide antigen assembly with MHC class II protein complex antigen processing and presentation of peptide or polysaccharide antigen via MHC class II polysaccharide assembly with MHC class II protein complex immune response viral process T cell costimulation T cell receptor signaling pathway cognition interferon-gamma-mediated signaling pathway

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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HLA-DR Monoclonal Antibody (LN3), APC, eBioscience™

HLA-DR Antibody (17-9956-42) in Flow

Product Details

17-9956-42

Western Blot (WB)

Immunohistochemistry (Frozen) (IHC (F))

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Recommended Isotype Control

Class

Type

Clone

Conjugate

Excitation/Emission Max

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

How to use the Panel Builder

Bioinformatics

Performance Guarantee

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