Product References
T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis.
Immunity
Briukhovetska D,Suarez-Gosalvez J,Voigt C,Markota A,Giannou AD,Schübel M,Jobst J,Zhang T,Dörr J,Märkl F,Majed L,Müller PJ,May P,Gottschlich A,Tokarew N,Lücke J,Oner A,Schwerdtfeger M,Andreu-Sanz D,Grünmeier R,Seifert M,Michaelides S,Hristov M,König LM,Cadilha BL,Mikhaylov O,Anders HJ,Rothenfusser S,Flavell RA,Cerezo-Wallis D,Tejedo C,Soengas MS,Bald T,Huber S,Endres S,Kobold S
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Jan 10 00:00:00 EST 2023
Biometabolites of Citrus unshiu Peel Enhance Intestinal Permeability and Alter Gut Commensal Bacteria.
Nutrients
Lee SH,Seo D,Lee KH,Park SJ,Park S,Kim H,Kim T,Joo IH,Park JM,Kang YH,Lim GH,Kim DH,Yang JY
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Jan 09 00:00:00 EST 2023
Klebsiella pneumoniae Induces Inflammatory Bowel Disease Through Caspase-11-Mediated IL18 in the Gut Epithelial Cells.
Cellular and molecular gastroenterology and hepatology
Zhang Q,Su X,Zhang C,Chen W,Wang Y,Yang X,Liu D,Zhang Y,Yang R
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Feb 23 00:00:00 EST 2023
Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge.
Biomaterials
Sun S,Li E,Zhao G,Tang J,Zuo Q,Cai L,Xu C,Sui C,Ou Y,Liu C,Li H,Ding Y,Li C,Lu D,Zhang W,Luo P,Cheng P,Gao Y,Tu C,Pitard B,Rosenecker J,Wang B,Liu Y,Zou Q,Guan S
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2023
Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ-stimulated antitumor immunity.
The Journal of clinical investigation
Ren J,Li N,Pei S,Lian Y,Li L,Peng Y,Liu Q,Guo J,Wang X,Han Y,Zhang G,Wang H,Li Y,Jiang J,Li Q,Tan M,Peng J,Hu G,Xiao Y,Li X,Lin M,Qin J
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Fri Apr 15 00:00:00 EDT 2022
A peptide encoded by pri-miRNA-31 represses autoimmunity by promoting Treg differentiation.
EMBO reports
Zhou H,Lou F,Bai J,Sun Y,Cai W,Sun L,Xu Z,Liu Z,Zhang L,Yin Q,Zhang J,Gao Y,Wang Z,Niu L,Cai X,Deng S,Wang H,Xia L,Ginhoux F,Li Q,Wang H
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Wed May 04 00:00:00 EDT 2022
Penfluridol targets acid sphingomyelinase to inhibit TNF signaling and is therapeutic against inflammatory autoimmune diseases.
Arthritis research & therapy
Chen YH,Liu RH,Cui YZ,Hettinghouse A,Fu WY,Zhang L,Zhang C,Liu CJ
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Wed Jan 19 00:00:00 EST 2022
Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2.
Nature communications
Wilson AS,Randall KL,Pettitt JA,Ellyard JI,Blumenthal A,Enders A,Quah BJ,Bopp T,Parish CR,Brüstle A
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Wed Jan 26 00:00:00 EST 2022
Forsythiaside A Improves the Inhibitory Efficiency of Recombinant Protein Vaccines against Bovine Viral Diarrhea Virus Infection.
International journal of molecular sciences
Yang G,Wang J,Wang S,Zhu Y
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Sat Aug 20 00:00:00 EDT 2022
Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer.
eLife
Wang Y,Yang H,Jia A,Wang Y,Yang Q,Dong Y,Hou Y,Cao Y,Dong L,Bi Y,Liu G
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Aug 22 00:00:00 EDT 2022
Leishmania donovani Impedes Antileishmanial Immunity by Suppressing Dendritic Cells via the TIM-3 Receptor.
mBio
Akhtar MN,Kumar S,Sen P
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Aug 30 00:00:00 EDT 2022
Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103+ dendritic cell IL-23-dependent ileocolitis.
Cell reports
Viladomiu M,Khounlotham M,Dogan B,Lima SF,Elsaadi A,Cardakli E,Castellanos JG,Ng C,Herzog J,Schoenborn AA,Ellermann M,Liu B,Zhang S,Gulati AS,Sartor RB,Simpson KW,Lipkin SM,Longman RS
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Nov 15 00:00:00 EST 2022
Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression.
Nature communications
Qi M,Xia Y,Wu Y,Zhang Z,Wang X,Lu L,Dai C,Song Y,Xu K,Ji W,Zhan L
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Wed Feb 16 00:00:00 EST 2022
Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling.
Nature communications
Xie F,Zhou X,Su P,Li H,Tu Y,Du J,Pan C,Wei X,Zheng M,Jin K,Miao L,Wang C,Meng X,van Dam H,Ten Dijke P,Zhang L,Zhou F
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2022
Local and Systemic Injections of Human Cord Blood Myeloid-Derived Suppressor Cells to Prevent Graft Rejection in Corneal Transplantation.
Biomedicines
Lee JY,Sohn HJ,Kim CH,Kim TG,Lee HS
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Dec 12 00:00:00 EST 2022
Transcription factor RORα enforces stability of the Th17 cell effector program by binding to a Rorc cis-regulatory element.
Immunity
Hall JA,Pokrovskii M,Kroehling L,Kim BR,Kim SY,Wu L,Lee JY,Littman DR
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Nov 08 00:00:00 EST 2022
Lactate induces metabolic and epigenetic reprogramming of pro-inflammatory Th17 cells.
EMBO reports
Lopez Krol A,Nehring HP,Krause FF,Wempe A,Raifer H,Nist A,Stiewe T,Bertrams W,Schmeck B,Luu M,Leister H,Chung HR,Bauer UM,Adhikary T,Visekruna A
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Dec 06 00:00:00 EST 2022
Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota.
Cell
Lima-Junior DS,Krishnamurthy SR,Bouladoux N,Collins N,Han SJ,Chen EY,Constantinides MG,Link VM,Lim AI,Enamorado M,Cataisson C,Gil L,Rao I,Farley TK,Koroleva G,Attig J,Yuspa SH,Fischbach MA,Kassiotis G,Belkaid Y
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Jul 08 00:00:00 EDT 2021
The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice.
Immunity
Shreeve N,Depierreux D,Hawkes D,Traherne JA,Sovio U,Huhn O,Jayaraman J,Horowitz A,Ghadially H,Perry JRB,Moffett A,Sled JG,Sharkey AM,Colucci F
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Jun 08 00:00:00 EDT 2021
The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13.
Cellular & molecular immunology
Mulas F,Wang X,Song S,Nishanth G,Yi W,Brunn A,Larsen PK,Isermann B,Kalinke U,Barragan A,Naumann M,Deckert M,Schlüter D
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Jun 01 00:00:00 EDT 2021
Themis regulates metabolic signaling and effector functions in CD4+ T cells by controlling NFAT nuclear translocation.
Cellular & molecular immunology
Prasad M,Brzostek J,Gautam N,Balyan R,Rybakin V,Gascoigne NRJ
12-7311 was used in Flow cytometry/Cell sorting to describe an internal circuit between TCR signal transduction, NFAT nuclear translocation, and metabolic signaling in CD4+ T cells.
Wed Sep 01 00:00:00 EDT 2021
AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis.
The Journal of experimental medicine
Ma C,Li S,Hu Y,Ma Y,Wu Y,Wu C,Liu X,Wang B,Hu G,Zhou J,Yang S
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon May 03 00:00:00 EDT 2021
Mapping and role of T cell response in SARS-CoV-2-infected mice.
The Journal of experimental medicine
Zhuang Z,Lai X,Sun J,Chen Z,Zhang Z,Dai J,Liu D,Li Y,Li F,Wang Y,Zhu A,Wang J,Yang W,Huang J,Li X,Hu L,Wen L,Zhuo J,Zhang Y,Chen D,Li S,Huang S,Shi Y,Zheng K,Zhong N,Zhao J,Zhou D,Zhao J
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Apr 05 00:00:00 EDT 2021
Low immunogenicity of malaria pre-erythrocytic stages can be overcome by vaccination.
EMBO molecular medicine
Müller K,Gibbins MP,Roberts M,Reyes-Sandoval A,Hill AVS,Draper SJ,Matuschewski K,Silvie O,Hafalla JCR
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Fri Apr 09 00:00:00 EDT 2021
High Ambient Temperature Aggravates Experimental Autoimmune Uveitis Symptoms.
Frontiers in cell and developmental biology
Pan S,Tan H,Chang R,Wang Q,Zhu Y,Chen L,Li H,Su G,Zhou C,Cao Q,Kijlstra A,Yang P
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Apr 13 00:00:00 EDT 2021
Senescent T Cell Induces Brown Adipose Tissue "Whitening" Via Secreting IFN-γ.
Frontiers in cell and developmental biology
Pan XX,Yao KL,Yang YF,Ge Q,Zhang R,Gao PJ,Ruan CC,Wu F
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Mar 23 00:00:00 EDT 2021
Trichinella spiralis Paramyosin Induces Colonic Regulatory T Cells to Mitigate Inflammatory Bowel Disease.
Frontiers in cell and developmental biology
Hao C,Wang W,Zhan B,Wang Z,Huang J,Sun X,Zhu X
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Aug 03 00:00:00 EDT 2021
Prevention of EAE by tolerogenic vaccination with PEGylated antigenic peptides.
Therapeutic advances in chronic disease
Pfeil J,Simonetti M,Lauer U,von Thülen B,Durek P,Poulsen C,Pawlowska J,Kröger M,Krähmer R,Leenders F,Hoffmann U,Hamann A
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Nov 07 00:00:00 EST 2023
Generation of a Novel Oncolytic Vaccinia Virus Using the IHD-W Strain.
Human gene therapy
Shin J,Hong SO,Kim M,Lee H,Choi H,Kim J,Hong J,Kang H,Lee E,Lee S,Kong B,Kim M,Choi H,Kim S
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Identification of CTL Epitopes on Efflux Pumps of the ATP-Binding Cassette and the Major Facilitator Superfamily of Mycobacterium tuberculosis.
Journal of immunology research
Lin Y,Dong Y,Gao Y,Shi R,Li Y,Zhou X,Liu W,Li G,Qi Y,Wu Y
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Sep 20 00:00:00 EDT 2021
Fine particulate matter induces airway inflammation by disturbing the balance between Th1/Th2 and regulation of GATA3 and Runx3 expression in BALB/c mice.
Molecular medicine reports
Pang L,Yu P,Liu X,Fan Y,Shi Y,Zou S
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells.
Oncology letters
Chen J,Ding Y,Huang F,Lan R,Wang Z,Huang W,Chen R,Wu B,Fu L,Yang Y,Liu J,Hong J,Zhang W,Zhang L
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Features of T-cell subset composition in a D-galactose-induced senescence mouse model.
Experimental animals
Kawata K,Suzuki T,Ozawa K,Sekiguchi M
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Fri Aug 06 00:00:00 EDT 2021
T cell-derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death.
JCI insight
Chun N,Ang RL,Chan M,Fairchild RL,Baldwin WM,Horwitz JK,Gelles JD,Chipuk JE,Kelliher MA,Pavlov VI,Li Y,Homann D,Heeger PS,Ting AT
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Wed Dec 22 00:00:00 EST 2021
Antitumor efficacy of a neoantigen cancer vaccine delivered by electroporation is influenced by microbiota composition.
Oncoimmunology
Lione L,Salvatori E,Petrazzuolo A,Massacci A,Maggio R,Confroti A,Compagnone M,Aurisicchio L,Ciliberto G,Palombo F
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Mar 23 00:00:00 EDT 2021
PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory.
Cell reports
Cannons JL,Villarino AV,Kapnick SM,Preite S,Shih HY,Gomez-Rodriguez J,Kaul Z,Shibata H,Reilley JM,Huang B,Handon R,McBain IT,Gossa S,Wu T,Su HC,McGavern DB,O'Shea JJ,McGuire PJ,Uzel G,Schwartzberg PL
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Oct 12 00:00:00 EDT 2021
Expansion of an Unusual Virtual Memory CD8+ Subpopulation Bearing Vα3.2 TCR in Themis-Deficient Mice.
Frontiers in immunology
Prasad M,Wojciech L,Brzostek J,Hu J,Chua YL,Tung DWH,Yap J,Rybakin V,Gascoigne NRJ
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Sep 23 00:00:00 EDT 2021
Type 1 Cytotoxic T Cells Increase in Placenta after Intrauterine Inflammation.
Frontiers in immunology
Liu J,Liu Y,Panda S,Liu A,Lei J,Burd I
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Fri Dec 17 00:00:00 EST 2021
Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity.
The Journal of biological chemistry
Tsai SJ,Atai NA,Cacciottolo M,Nice J,Salehi A,Guo C,Sedgwick A,Kanagavelu S,Gould SJ
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Nov 01 00:00:00 EDT 2021
Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer.
Nature communications
Huang Y,Guan Z,Dai X,Shen Y,Wei Q,Ren L,Jiang J,Xiao Z,Jiang Y,Liu D,Huang Z,Xu X,Luo Y,Zhao C
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Wed Jul 14 00:00:00 EDT 2021
Mechanisms that allow vaccination against an oncolytic vesicular stomatitis virus-encoded transgene to enhance safety without abrogating oncolysis.
Scientific reports
AuYeung AWK,Mould RC,Stegelmeier AA,van Vloten JP,Karimi K,Woods JP,Petrik JJ,Wood GA,Bridle BW
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Jul 27 00:00:00 EDT 2021
YY1 regulation by miR-124-3p promotes Th17 cell pathogenicity through interaction with T-bet in rheumatoid arthritis.
JCI insight
Lin J,Tang J,Lin J,He Y,Yu Z,Jiang R,Yang B,Ou Q
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Nov 22 00:00:00 EST 2021
Small Molecule Inhibitors Targeting Nuclear Factor κB Activation Markedly Reduce Expression of Interleukin-2, but Not Interferon-γ, Induced by Phorbol Esters and Calcium Ionophores.
International journal of molecular sciences
Tanaka Y,Nakao A,Miyake Y,Higashi Y,Tanigaki R,Kataoka T
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Fri Dec 03 00:00:00 EST 2021
Rate of Freeze Impacts the Survival and Immune Responses Post Cryoablation of Melanoma.
Frontiers in immunology
Yakkala C,Dagher J,Sempoux C,Chiang CL,Denys A,Kandalaft LE,Koppolu B,Duran R
12-7311-41 was used in Flow Cytometry to study fast freeze and slow freeze rates for their locoregional effectiveness and their ability to elicit immune responses in a B16F10 mouse model of melanoma.
Mon Dec 13 00:00:00 EST 2021
SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis.
iScience
Sangaletti S,Botti L,Gulino A,Lecis D,Bassani B,Portararo P,Milani M,Cancila V,De Cecco L,Dugo M,Tripodo C,Colombo MP
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Fri Jun 25 00:00:00 EDT 2021
TOX Acts as a Tumor Suppressor by Inhibiting mTOR Signaling in Colorectal Cancer.
Frontiers in immunology
Yang M,Huang Q,Li C,Jiang Z,Sun J,Wang Z,Liang R,Li D,Li B,Zhao H
12-7311-41 was used in Flow Cytometry to highlight the tumor-suppressive role of TOX in CRC, especially in MSI CRC, and provide valuable information that rapamycin alone or combined with PD1 inhibitor has therapeutic potential in CRC.
Wed Oct 06 00:00:00 EDT 2021
Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection.
iScience
Steele L,Mannion AJ,Shaw G,Maclennan KA,Cook GP,Rudd CE,Taylor A
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Fri Jun 25 00:00:00 EDT 2021
Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.
STAR protocols
Skordos I,Demeyer A,Beyaert R
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Fri Mar 19 00:00:00 EDT 2021
Oxygen-Enriched Metal-Phenolic X-Ray Nanoprocessor for Cancer Radio-Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Sang W,Xie L,Wang G,Li J,Zhang Z,Li B,Guo S,Deng CX,Dai Y
12-7311 was used in Flow cytometry/Cell sorting to presents a multifunctional metal-phenolic nanoplatform for efficient X-ray mediated RT-RDT in combination with immunotherapy and may provide a new therapeutic option for cancer treatment.
Mon Feb 01 00:00:00 EST 2021
Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer.
Cell
Zhang L,Li Z,Skrzypczynska KM,Fang Q,Zhang W,O'Brien SA,He Y,Wang L,Zhang Q,Kim A,Gao R,Orf J,Wang T,Sawant D,Kang J,Bhatt D,Lu D,Li CM,Rapaport AS,Perez K,Ye Y,Wang S,Hu X,Ren X,Ouyang W,Shen Z,Egen JG,Zhang Z,Yu X
12-7311-41 was used in Immunocytochemistry to identify critical cellular interactions regulating tumor immunity and defines mechanisms underlying myeloid-targeted immunotherapies currently undergoing clinical testing.
Thu Apr 16 00:00:00 EDT 2020
Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer.
Cell
Zhang L,Li Z,Skrzypczynska KM,Fang Q,Zhang W,O'Brien SA,He Y,Wang L,Zhang Q,Kim A,Gao R,Orf J,Wang T,Sawant D,Kang J,Bhatt D,Lu D,Li CM,Rapaport AS,Perez K,Ye Y,Wang S,Hu X,Ren X,Ouyang W,Shen Z,Egen JG,Zhang Z,Yu X
12-7311-41 was used in Immunocytochemistry to identify critical cellular interactions regulating tumor immunity and defines mechanisms underlying myeloid-targeted immunotherapies currently undergoing clinical testing.
Thu Apr 16 00:00:00 EDT 2020
Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer.
Cell
Zhang L,Li Z,Skrzypczynska KM,Fang Q,Zhang W,O'Brien SA,He Y,Wang L,Zhang Q,Kim A,Gao R,Orf J,Wang T,Sawant D,Kang J,Bhatt D,Lu D,Li CM,Rapaport AS,Perez K,Ye Y,Wang S,Hu X,Ren X,Ouyang W,Shen Z,Egen JG,Zhang Z,Yu X
12-7311-41 was used in Immunocytochemistry to identify critical cellular interactions regulating tumor immunity and defines mechanisms underlying myeloid-targeted immunotherapies currently undergoing clinical testing.
Thu Apr 16 00:00:00 EDT 2020
Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer.
Cell
Zhang L,Li Z,Skrzypczynska KM,Fang Q,Zhang W,O'Brien SA,He Y,Wang L,Zhang Q,Kim A,Gao R,Orf J,Wang T,Sawant D,Kang J,Bhatt D,Lu D,Li CM,Rapaport AS,Perez K,Ye Y,Wang S,Hu X,Ren X,Ouyang W,Shen Z,Egen JG,Zhang Z,Yu X
12-7311-41 was used in Immunocytochemistry to identify critical cellular interactions regulating tumor immunity and defines mechanisms underlying myeloid-targeted immunotherapies currently undergoing clinical testing.
Thu Apr 16 00:00:00 EDT 2020
Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.
Immunity
Bonavita E,Bromley CP,Jonsson G,Pelly VS,Sahoo S,Walwyn-Brown K,Mensurado S,Moeini A,Flanagan E,Bell CR,Chiang SC,Chikkanna-Gowda CP,Rogers N,Silva-Santos B,Jaillon S,Mantovani A,Reis e Sousa C,Guerra N,Davis DM,Zelenay S
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Dec 15 00:00:00 EST 2020
Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity.
Immunity
DiToro D,Harbour SN,Bando JK,Benavides G,Witte S,Laufer VA,Moseley C,Singer JR,Frey B,Turner H,Bruning J,Darley-Usmar V,Gao M,Conover C,Hatton RD,Frank S,Colonna M,Weaver CT
12-7311 was used in Flow cytometry/Cell sorting to show that, among effector T cell subsets, Th17 and Treg cells selectively expressed multiple components of the IGF system.
Tue Apr 14 00:00:00 EDT 2020
BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse.
Cell stem cell
Jia L,Zhang W,Wang CY
12-7311-41 was used in Flow Cytometry to suggest that targeting BMI1 may enable immune checkpoint blockade to inhibit metastatic tumor growth and prevent tumor relapse by activating cell-intrinsic immunity, in addition to purging CSCs.
Thu Aug 06 00:00:00 EDT 2020
Critical role of OX40 in drug-induced acute liver injury.
British journal of pharmacology
Zhang C,Jin H,Wang Y,Li C,Zhao X,Li Y,Shi W,Tian Y,Xu H,Tian D,Liu K,Jia J,Sun G,Zhang D
12-7311-41 was used in Flow Cytometry to show that OX40 is a key molecule that promotes both pro-inflammatory macrophage and CD4+ T-cell function, exacerbating paracetamol-induced liver injury.
Wed Jul 01 00:00:00 EDT 2020
PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2.
The Journal of cell biology
Xu X,Hou B,Fulzele A,Masubuchi T,Zhao Y,Wu Z,Hu Y,Jiang Y,Ma Y,Wang H,Bennett EJ,Fu G,Hui E
12-7311 was used in Flow cytometry/Cell sorting to compare the abilities of BTLA and PD-1 to recruit effector molecules and to regulate T cell signalling.
Mon Jun 01 00:00:00 EDT 2020
PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2.
The Journal of cell biology
Xu X,Hou B,Fulzele A,Masubuchi T,Zhao Y,Wu Z,Hu Y,Jiang Y,Ma Y,Wang H,Bennett EJ,Fu G,Hui E
12-7311 was used in Flow cytometry/Cell sorting to compare the abilities of BTLA and PD-1 to recruit effector molecules and to regulate T cell signalling.
Mon Jun 01 00:00:00 EDT 2020
Runx proteins mediate protective immunity against Leishmania donovani infection by promoting CD40 expression on dendritic cells.
PLoS pathogens
Akhtar MN,Mishra M,Yadav V,Yadav M,Gujar R,Lal S,Kumar R,Khatri N,Sen P
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2020
DKK2 blockage-mediated immunotherapy enhances anti-angiogenic therapy of Kras mutated colorectal cancer.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Hu J,Wang Z,Chen Z,Li A,Sun J,Zheng M,Wu J,Shen T,Qiao J,Li L,Li B,Wu D,Xiao Q
12-7311-41 was used in Flow Cytometry to demonstrate that if in human colorectal cancer tumor samples expressing high levels of DKK2, DKK2 blockade cause stronger activation of tumor infiltrating CD8+ T cells in ex vivo culture.
Wed Jul 01 00:00:00 EDT 2020
Expression of CD27 and CD28 on γδ T cells from the peripheral blood of patients with allergic rhinitis.
Experimental and therapeutic medicine
Wang Q,Sun Q,Chen Q,Li H,Liu D
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2020
Increase in liver γδ T cells with concurrent augmentation of IFN-β production during the early stages of a mouse model of acute experimental hepatitis B virus infection.
Experimental and therapeutic medicine
Chang L,Wang L,Ling N,Peng H,Chen M
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Wed Jan 01 00:00:00 EST 2020
Isolation and functional characterisation of lamina propria leukocytes from helminth-infected, murine small intestine.
Journal of immunological methods
Webster HC,Andrusaite AT,Shergold AL,Milling SWF,Perona-Wright G
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Sat Feb 01 00:00:00 EST 2020
Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease.
Cell reports
Nguyen HD,Ticer T,Bastian D,Kuril S,Li H,Du H,Yan C,Yu XZ
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Oct 27 00:00:00 EDT 2020
C5aR1 Activation Drives Early IFN-γ Production to Control Experimental Toxoplasma gondii Infection.
Frontiers in immunology
Briukhovetska D,Ohm B,Mey FT,Aliberti J,Kleingarn M,Huber-Lang M,Karsten CM,Köhl J
12-7311 was used in Flow cytometry/Cell sorting to suggest a model in which the C5a/C5aR1 axis promotes IFN-γ production from NK cells as a mechanism to control acute Toxoplasma gondii infection.
Mon Apr 05 00:00:00 EDT 2021
C5aR1 Activation Drives Early IFN-γ Production to Control Experimental Toxoplasma gondii Infection.
Frontiers in immunology
Briukhovetska D,Ohm B,Mey FT,Aliberti J,Kleingarn M,Huber-Lang M,Karsten CM,Köhl J
12-7311 was used in Flow cytometry/Cell sorting to suggest a model in which the C5a/C5aR1 axis promotes IFN-γ production from NK cells as a mechanism to control acute Toxoplasma gondii infection.
Mon Apr 05 00:00:00 EDT 2021
Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection.
Cell reports
Cham LB,Torrez Dulgeroff LB,Tal MC,Adomati T,Li F,Bhat H,Huang A,Lang PA,Moreno ME,Rivera JM,Galkina SA,Kosikova G,Stoddart CA,McCune JM,Myers LM,Weissman IL,Lang KS,Hasenkrug KJ
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Apr 14 00:00:00 EDT 2020
FUT1 deficiency elicits immune dysregulation and corneal opacity in steady state and under stress.
Cell death & disease
Kim KW,Ryu JS,Ko JH,Kim JY,Kim HJ,Lee HJ,Oh JH,Chung JH,Oh JY
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Fri Apr 24 00:00:00 EDT 2020
Deletion of immune evasion genes provides an effective vaccine design for tumor-associated herpesviruses.
NPJ vaccines
Brar G,Farhat NA,Sukhina A,Lam AK,Kim YH,Hsu T,Tong L,Lin WW,Ware CF,Blackman MA,Sun R,Wu TT
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Nov 05 00:00:00 EST 2020
Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.
International journal of molecular sciences
Yoon CH,Ryu JS,Hwang HS,Kim MK
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Jun 11 00:00:00 EDT 2020
BCG vaccination reduces the mortality of Mycobacterium tuberculosis-infected type 2 diabetes mellitus mice.
JCI insight
Radhakrishnan RK,Thandi RS,Tripathi D,Paidipally P,McAllister MK,Mulik S,Samten B,Vankayalapati R
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Mar 12 00:00:00 EDT 2020
Tumors induce de novo steroid biosynthesis in T cells to evade immunity.
Nature communications
Mahata B,Pramanik J,van der Weyden L,Polanski K,Kar G,Riedel A,Chen X,Fonseca NA,Kundu K,Campos LS,Ryder E,Duddy G,Walczak I,Okkenhaug K,Adams DJ,Shields JD,Teichmann SA
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Fri Jul 17 00:00:00 EDT 2020
Targeting the orphan nuclear receptor NR2F6 in T cells primes tumors for immune checkpoint therapy.
Cell communication and signaling : CCS
Klepsch V,Pommermayr M,Humer D,Brigo N,Hermann-Kleiter N,Baier G
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Jan 14 00:00:00 EST 2020
TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response.
Nature communications
Chen J,He R,Sun W,Gao R,Peng Q,Zhu L,Du Y,Ma X,Guo X,Zhang H,Tan C,Wang J,Zhang W,Weng X,Man J,Bauer H,Wang QK,Martin BN,Zhang CJ,Li X,Wang C
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Apr 20 00:00:00 EDT 2020
Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation.
Nature communications
Iske J,Seyda M,Heinbokel T,Maenosono R,Minami K,Nian Y,Quante M,Falk CS,Azuma H,Martin F,Passos JF,Niemann CU,Tchkonia T,Kirkland JL,Elkhal A,Tullius SG
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Aug 27 00:00:00 EDT 2020
PCC0208025 (BMS202), a small molecule inhibitor of PD-L1, produces an antitumor effect in B16-F10 melanoma-bearing mice.
PloS one
Hu Z,Yu P,Du G,Wang W,Zhu H,Li N,Zhao H,Dong Z,Ye L,Tian J
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Jun 22 00:00:00 EDT 2020
PCC0208025 (BMS202), a small molecule inhibitor of PD-L1, produces an antitumor effect in B16-F10 melanoma-bearing mice.
PloS one
Hu Z,Yu P,Du G,Wang W,Zhu H,Li N,Zhao H,Dong Z,Ye L,Tian J
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Jun 22 00:00:00 EDT 2020
Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and Cytotoxicity.
Cell reports
Wagner JA,Wong P,Schappe T,Berrien-Elliott MM,Cubitt C,Jaeger N,Lee M,Keppel CR,Marin ND,Foltz JA,Marsala L,Neal CC,Sullivan RP,Schneider SE,Keppel MP,Saucier N,Cooper MA,Fehniger TA
12-7311 was used in Flow cytometry/Cell sorting to develop a tamoxifen-inducible, type-1-ILC-specific (Ncr1-targeted) cre mouse and combine this with Eomes-floxed mice.
Tue Jun 02 00:00:00 EDT 2020
Landscape of Exhausted Virus-Specific CD8 T Cells in Chronic LCMV Infection.
Cell reports
Sandu I,Cerletti D,Oetiker N,Borsa M,Wagen F,Spadafora I,Welten SPM,Stolz U,Oxenius A,Claassen M
12-7311-41 was used in Flow Cytometry to reveal that exhausted cells are heterogeneous, adopt organ-specific transcriptomic profiles, and can be divided into five main functional subpopulations: advanced exhaustion, effector-like, intermediate, proliferating, or memory-like.
Tue Aug 25 00:00:00 EDT 2020
Bendamustine with total body irradiation conditioning yields tolerant T-cells while preserving T-cell-dependent graft-versus-leukemia.
Oncoimmunology
Stokes J,Hoffman EA,Molina MS,Kummet N,Simpson RJ,Zeng Y,Katsanis E
12-7311 was used in Flow cytometry/Cell sorting to demonstrate that BEN-TBI reduces graft-versus-host disease (GvHD) compared to CY-TBI independently of T regulatory cells (Tregs).
Wed Jul 14 00:00:00 EDT 2021
Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development.
Cell reports
Ramstead AG,Wallace JA,Lee SH,Bauer KM,Tang WW,Ekiz HA,Lane TE,Cluntun AA,Bettini ML,Round JL,Rutter J,O'Connell RM
12-7311 was used in Flow cytometry/Cell sorting to demonstrate that pyruvate oxidation by T cell precursors is necessary for optimal αβ T cell development.
Tue Mar 03 00:00:00 EST 2020
Bmal1 integrates mitochondrial metabolism and macrophage activation.
eLife
Alexander RK,Liou YH,Knudsen NH,Starost KA,Xu C,Hyde AL,Liu S,Jacobi D,Liao NS,Lee CH
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue May 12 00:00:00 EDT 2020
Bmal1 integrates mitochondrial metabolism and macrophage activation.
eLife
Alexander RK,Liou YH,Knudsen NH,Starost KA,Xu C,Hyde AL,Liu S,Jacobi D,Liao NS,Lee CH
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue May 12 00:00:00 EDT 2020
Modulation of Vaccine-Induced HIV-1-Specific Immune Responses by Co-Electroporation of PD-L1 Encoding DNA.
Vaccines
Tannig P,Peter AS,Lapuente D,Klessing S,Damm D,Tenbusch M,Überla K,Temchura V
12-7311-41 was used in Flow Cytometry to indicate that co-electroporation of soluble checkpoint ectodomains together with DNA-based vaccines has modulatory effects on vaccine-induced immune responses that could improve vaccine efficacies.
Tue Jan 14 00:00:00 EST 2020
Tolerogenic Immunomodulation by PEGylated Antigenic Peptides.
Frontiers in immunology
Pfeil J,Simonetti M,Lauer U,Volkmer R,von Thülen B,Durek P,Krähmer R,Leenders F,Hamann A,Hoffmann U
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Apr 29 00:00:00 EDT 2021
Inflammation-Induced Lactate Leads to Rapid Loss of Hepatic Tissue-Resident NK Cells.
Cell reports
Dodard G,Tata A,Erick TK,Jaime D,Miah SMS,Quatrini L,Escalière B,Ugolini S,Vivier E,Brossay L
12-7311 was used in Flow cytometry/Cell sorting to characterize the kinetics and immune response of each of the hepatic NK cell populations to viral challenge and other stimuli.
Tue Jul 07 00:00:00 EDT 2020
Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling.
Frontiers in immunology
Yu Y,Wu DM,Li J,Deng SH,Liu T,Zhang T,He M,Zhao YY,Xu Y
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Jun 21 00:00:00 EDT 2021
Manipulation of the tumor microenvironment by cytokine gene transfection enhances dendritic cell-based immunotherapy.
FASEB bioAdvances
Wijesekera DPH,Yuba E,De Silva NH,Watanabe SI,Tsukamoto M,Ichida C,Izawa T,Itoh K,Kanegi R,Hatoya S,Yamate J,Inaba T,Sugiura K
12-7311-41 was used in Flow Cytometry to manipulate the microenvironment so as to elicit activation of T helper type 1 (Th1) responses and the maturation of dendritic cells (DCs).
Wed Jan 01 00:00:00 EST 2020
Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells.
Cell
Miao Y,Yang H,Levorse J,Yuan S,Polak L,Sribour M,Singh B,Rosenblum MD,Fuchs E
12-7311 was used in Flow cytometry/Cell sorting to place tSCs at the crux of how immune checkpoint pathways are activated.
Thu May 16 00:00:00 EDT 2019
Negative Co-stimulation Constrains T Cell Differentiation by Imposing Boundaries on Possible Cell States.
Immunity
Wei SC,Sharma R,Anang NAS,Levine JH,Zhao Y,Mancuso JJ,Setty M,Sharma P,Wang J,Pe'er D,Allison JP
12-7311 was used in Flow cytometry/Cell sorting to implicate negative co-stimulation as a key regulator and determinant of T cell differentiation and suggest that checkpoint blockade might work in part by altering the limits of T cell phenotypes.
Tue Apr 16 00:00:00 EDT 2019
Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell-mediated tumor regression.
The Journal of experimental medicine
Etzerodt A,Tsalkitzi K,Maniecki M,Damsky W,Delfini M,Baudoin E,Moulin M,Bosenberg M,Graversen JH,Auphan-Anezin N,Moestrup SK,Lawrence T
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Oct 07 00:00:00 EDT 2019
miR-146a Controls Immune Response in the Melanoma Microenvironment.
Cancer research
Mastroianni J,Stickel N,Andrlova H,Hanke K,Melchinger W,Duquesne S,Schmidt D,Falk M,Andrieux G,Pfeifer D,Dierbach H,Schmitt-Graeff A,Meiss F,Boerries M,Zeiser R
12-7311-41 was used in Flow Cytometry to identify miR-146a as a negative regulator of immune activation, comparable to immune-checkpoint molecules.
Tue Jan 01 00:00:00 EST 2019
BTK signaling drives CD1dhiCD5+ regulatory B-cell differentiation to promote pancreatic carcinogenesis.
Oncogene
Das S,Bar-Sagi D
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Apr 01 00:00:00 EDT 2019
The ROP16III-dependent early immune response determines the subacute CNS immune response and type III Toxoplasma gondii survival.
PLoS pathogens
Tuladhar S,Kochanowsky JA,Bhaskara A,Ghotmi Y,Chandrasekaran S,Koshy AA
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2019
Bryostatin-1 ameliorated experimental colitis in Il-10-/- Mice by protecting the intestinal barrier and limiting immune dysfunction.
Journal of cellular and molecular medicine
Zuo L,Li J,Ge S,Ge Y,Shen M,Wang Y,Zhou C,Wu R,Hu J
12-7311-41 was used in Flow cytometry/Cell sorting to investigate the impact of Bry-1 on CD-like colitis and determine the mechanism underlying this effect.
Thu Aug 01 00:00:00 EDT 2019
CD8+ T cells promote cytokine responses to stress.
Cytokine
Clark SM,Song C,Li X,Keegan AD,Tonelli LH
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Jan 01 00:00:00 EST 2019
Ovalbumin induces natural killer cells to secrete Th2 cytokines IL‑5 and IL‑13 in a mouse model of asthma.
Molecular medicine reports
Chen Z,Wang L
12-7311-41 was used in Flow Cytometry to analyse the dynamic changes of NK cells and their subsets during the development of the ovalbumin (OVA)‚induced allergic airway response.
Mon Apr 01 00:00:00 EDT 2019
Regulation of host immune cells and cytokine production induced by Trichinella spiralis infection.
Parasite (Paris, France)
Song Y,Xu J,Wang X,Yang Y,Bai X,Pang J,Wang X,Yu M,Liu M,Liu X,Sun S
12-7311 was used in Flow cytometry/Cell sorting to examine immune cells and cytokine profiles of Trichinella spiralis infected mice by Meso Scale Discovery (MSD) and flow cytometry.
Fri May 08 00:00:00 EDT 2020
IL-31 plays dual roles in lung inflammation in an OVA-induced murine asthma model.
Biology open
Huang J,Yue H,Jiang T,Gao J,Shi Y,Shi B,Wu X,Gou X
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Jan 15 00:00:00 EST 2019
An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses.
NPJ vaccines
Li G,Adam A,Luo H,Shan C,Cao Z,Fontes-Garfias CR,Sarathy VV,Teleki C,Winkelmann ER,Liang Y,Sun J,Bourne N,Barrett ADT,Shi PY,Wang T
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2020
An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses.
NPJ vaccines
Li G,Adam A,Luo H,Shan C,Cao Z,Fontes-Garfias CR,Sarathy VV,Teleki C,Winkelmann ER,Liang Y,Sun J,Bourne N,Barrett ADT,Shi PY,Wang T
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2020
Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.
Frontiers in immunology
Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Wed Oct 14 00:00:00 EDT 2020
A chemical biology toolbox to study protein methyltransferases and epigenetic signaling.
Nature communications
Scheer S,Ackloo S,Medina TS,Schapira M,Li F,Ward JA,Lewis AM,Northrop JP,Richardson PL,Kaniskan HÜ,Shen Y,Liu J,Smil D,McLeod D,Zepeda-Velazquez CA,Luo M,Jin J,Barsyte-Lovejoy D,Huber KVM,De Carvalho DD,Vedadi M,Zaph C,Brown PJ,Arrowsmith CH
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Jan 03 00:00:00 EST 2019
ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.
Nature communications
Cao Y,Trillo-Tinoco J,Sierra RA,Anadon C,Dai W,Mohamed E,Cen L,Costich TL,Magliocco A,Marchion D,Klar R,Michel S,Jaschinski F,Reich RR,Mehrotra S,Cubillos-Ruiz JR,Munn DH,Conejo-Garcia JR,Rodriguez PC
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Wed Mar 20 00:00:00 EDT 2019
Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy.
Nature communications
Shi L,Wang J,Ding N,Zhang Y,Zhu Y,Dong S,Wang X,Peng C,Zhou C,Zhou L,Li X,Shi H,Wu W,Long X,Wu C,Liao W
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Nov 28 00:00:00 EST 2019
Requirement of Mitochondrial Transcription Factor A in Tissue-Resident Regulatory T Cell Maintenance and Function.
Cell reports
Fu Z,Ye J,Dean JW,Bostick JW,Weinberg SE,Xiong L,Oliff KN,Chen ZE,Avram D,Chandel NS,Zhou L
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Jul 02 00:00:00 EDT 2019
Type I Interferon Delivery by iPSC-Derived Myeloid Cells Elicits Antitumor Immunity via XCR1+ Dendritic Cells.
Cell reports
Tsuchiya N,Zhang R,Iwama T,Ueda N,Liu T,Tatsumi M,Sasaki Y,Shimoda R,Osako Y,Sawada Y,Kubo Y,Miyashita A,Fukushima S,Cheng Z,Nakaki R,Takubo K,Okada S,Kaneko S,Ihn H,Kaisho T,Nishimura Y,Senju S,Endo I,Nakatsura T,Uemura Y
12-7311 was used in Flow cytometry/Cell sorting to suggest that IFN-α-iPSC-pMCs might constitute effective immune-stimulating agents for cancer that are refractory to checkpoint blockade.
Tue Oct 01 00:00:00 EDT 2019
Synergized regulation of NK cell education by NKG2A and specific Ly49 family members.
Nature communications
Zhang X,Feng J,Chen S,Yang H,Dong Z
12-7311 was used in Flow cytometry/Cell sorting to provide genetic evidence supporting that NKG2A and the inhibitory members of Ly49 family receptors synergize to regulate NK cell education.
Fri Nov 01 00:00:00 EDT 2019
Qa-1-Restricted CD8+ T Cells Can Compensate for the Absence of Conventional T Cells during Viral Infection.
Cell reports
Anderson CK,Reilly EC,Lee AY,Brossay L
12-7311 was used in Flow cytometry/Cell sorting to study compensatory mechanisms in immune responses to viruses when classical T cell immunity has been evaded.
Tue Apr 09 00:00:00 EDT 2019
Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8+ T Cell Activation via Cross-Presentation in Type 1 Diabetes.
Frontiers in immunology
Liu C,Whitener RL,Lin A,Xu Y,Chen J,Savinov A,Leiding JW,Wallet MA,Mathews CE
12-7311-41 was used in Flow Cytometry to demonstrate that Ncf1 (p47phox) is required for activation and effector function of CD8+ T cells by acting both intrinsically within the T cell as well as within professional antigen presenting cells.
Wed Sep 09 00:00:00 EDT 2020
Noc4L-Mediated Ribosome Biogenesis Controls Activation of Regulatory and Conventional T Cells.
Cell reports
Zhu X,Zhang W,Guo J,Zhang X,Li L,Wang T,Yan J,Zhang F,Hou B,Gao N,Gao GF,Zhou X
12-7311 was used in Flow cytometry/Cell sorting to identify the control of Treg activation and immune tolerance maintenance is due to Noc4L mediated ribosome biogenesis.
Tue Apr 23 00:00:00 EDT 2019
Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis.
Nature communications
Ramakrishna C,Kujawski M,Chu H,Li L,Mazmanian SK,Cantin EM
12-7311 was used in Flow cytometry/Cell sorting to study polysaccharide A as an immunomodulatory symbiosis factor whcih coordinates anti-inflammatory responses during viral infections.
Tue May 14 00:00:00 EDT 2019
Innate-Like Lymphocytes Are Immediate Participants in the Hyper-Acute Immune Response to Trauma and Hemorrhagic Shock.
Frontiers in immunology
Manson J,Hoffman R,Chen S,Ramadan MH,Billiar TR
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Oct 13 00:00:00 EDT 2020
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death.
Nature communications
Sasaki K,Himeno A,Nakagawa T,Sasaki Y,Kiyonari H,Iwai K
12-7311-41 was used in Flow Cytometry to show that T cell-mediated killing and sequential autoinflammation are common and crucial for pathogenic diversity during T cell-mediated autoimmune responses.
Wed Aug 28 00:00:00 EDT 2019
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Cell
Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Jun 28 00:00:00 EDT 2018
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Jan 25 00:00:00 EST 2018
SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer.
Immunity
Malik A,Sharma D,Malireddi RKS,Guy CS,Chang TC,Olsen SR,Neale G,Vogel P,Kanneganti TD
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Sep 18 00:00:00 EDT 2018
Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis.
Immunity
Hirota K,Hashimoto M,Ito Y,Matsuura M,Ito H,Tanaka M,Watanabe H,Kondoh G,Tanaka A,Yasuda K,Kopf M,Potocnik AJ,Stockinger B,Sakaguchi N,Sakaguchi S
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Jun 19 00:00:00 EDT 2018
Cambogin suppresses dextran sulphate sodium-induced colitis by enhancing Treg cell stability and function.
British journal of pharmacology
Lu Y,Kim NM,Jiang YW,Zhang H,Zheng D,Zhu FX,Liang R,Li B,Xu HX
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Sun Apr 01 00:00:00 EDT 2018
Multipotent Adult Progenitor Cells Suppress T Cell Activation in In Vivo Models of Homeostatic Proliferation in a Prostaglandin E2-Dependent Manner.
Frontiers in immunology
Carty F,Corbett JM,Cunha JPMCM,Reading JL,Tree TIM,Ting AE,Stubblefield SR,English K
12-7311 was used in Flow cytometry/Cell sorting to investigate, using a mouse model of homeostatic proliferation, the immunosuppressive properties of multipotent adult progenitor cells, through their ability to control T cell proliferation.
Tue Jun 25 00:00:00 EDT 2019
RhoA Drives T-Cell Activation and Encephalitogenic Potential in an Animal Model of Multiple Sclerosis.
Frontiers in immunology
Manresa-Arraut A,Johansen FF,Brakebusch C,Issazadeh-Navikas S,Hasseldam H
12-7311 was used in Flow cytometry/Cell sorting to investigate the role of RhoA in T-cell development, functionality, and encephalitogenic potential in EAE.
Tue Aug 13 00:00:00 EDT 2019
Varying Immunizations With Plasmodium Radiation-Attenuated Sporozoites Alter Tissue-Specific CD8+ T Cell Dynamics.
Frontiers in immunology
Frank R,Gabel M,Heiss K,Mueller AK,Graw F
12-7311 was used in Flow cytometry/Cell sorting to determine how the generation of immunity is affected by vaccination dosage and frequency.
Tue Jul 30 00:00:00 EDT 2019
De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages.
Frontiers in immunology
Stüve P,Minarrieta L,Erdmann H,Arnold-Schrauf C,Swallow M,Guderian M,Krull F,Hölscher A,Ghorbani P,Behrends J,Abraham WR,Hölscher C,Sparwasser TD,Berod L
12-7311-41 was used in Flow Cytometry to reveal that acetyl-CoA carboxylase 1-dependent fatty acid synthesis is a crucial mechanism in T cells, but not dendritic cells or macrophages, to fight against mycobacterial infection.
Wed Apr 10 00:00:00 EDT 2019
Frontline Science: Anti-PD-L1 protects against infection with common bacterial pathogens after burn injury.
Journal of leukocyte biology
Patil NK,Luan L,Bohannon JK,Hernandez A,Guo Y,Sherwood ER
12-7311 was used in Flow cytometry/Cell sorting to evaluate the efficacy of anti-PD-L1 against bacterial infection following burn injury.
Mon Jan 01 00:00:00 EST 2018
MicroRNA-126 deficiency enhanced the activation and function of CD4+ T cells by elevating IRS-1 pathway.
Clinical and experimental immunology
Chu F,Hu Y,Zhou Y,Guo M,Lu J,Zheng W,Xu H,Zhao J,Xu L
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Feb 01 00:00:00 EST 2018
Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis.
Evidence-based complementary and alternative medicine : eCAM
Pang P,Zheng K,Wu S,Xu H,Deng L,Shi Y,Chen X
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2020
mTOR Modulates CD8+ T Cell Differentiation in Mice with Invasive Pulmonary Aspergillosis.
Open life sciences
Wang H,Xiao Y,Su L,Cui N,Liu D
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Jan 01 00:00:00 EST 2018
Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.
Nature communications
Sun C,Lan P,Han Q,Huang M,Zhang Z,Xu G,Song J,Wang J,Wei H,Zhang J,Sun R,Zhang C,Tian Z
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Wed Mar 28 00:00:00 EDT 2018
Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae.
Nature communications
Chandra S,Gray J,Kiosses WB,Khurana A,Hitomi K,Crosby CM,Chawla A,Fu Z,Zhao M,Veerapen N,Richardson SK,Porcelli SA,Besra G,Howell AR,Sharma S,Peters B,Kronenberg M
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Oct 15 00:00:00 EDT 2018
Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2.
Nature communications
Liu Z,Ge Y,Wang H,Ma C,Feist M,Ju S,Guo ZS,Bartlett DL
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Nov 08 00:00:00 EST 2018
Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming.
Cell reports
Simula L,Pacella I,Colamatteo A,Procaccini C,Cancila V,Bordi M,Tregnago C,Corrado M,Pigazzi M,Barnaba V,Tripodo C,Matarese G,Piconese S,Campello S
12-7311 was used in Flow cytometry/Cell sorting to describe the crucial role of the mitochondrial protein Drp1 in T cell development and regulation of lymphocyte immune-surveillance.
Tue Dec 11 00:00:00 EST 2018
Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease.
JCI insight
Moreno-Fernandez ME,Giles DA,Stankiewicz TE,Sheridan R,Karns R,Cappelletti M,Lampe K,Mukherjee R,Sina C,Sallese A,Bridges JP,Hogan SP,Aronow BJ,Hoebe K,Divanovic S
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Mar 22 00:00:00 EDT 2018
Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis.
Nature communications
Kim DH,Park HJ,Lim S,Koo JH,Lee HG,Choi JO,Oh JH,Ha SJ,Kang MJ,Lee CM,Lee CG,Elias JA,Choi JM
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Feb 05 00:00:00 EST 2018
Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA.
Immunity
Coelho MA,de Carné Trécesson S,Rana S,Zecchin D,Moore C,Molina-Arcas M,East P,Spencer-Dene B,Nye E,Barnouin K,Snijders AP,Lai WS,Blackshear PJ,Downward J
12-7311-41 was used in Flow Cytometry to demonstrate that RAS can drive cell-intrinsic PD-L1 expression, thus presenting therapeutic opportunities to reverse the innately immunoresistant phenotype of RAS mutant cancers.
Tue Dec 19 00:00:00 EST 2017
Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity.
Immunity
Chang YH,Wang KC,Chu KL,Clouthier DL,Tran AT,Torres Perez MS,Zhou AC,Abdul-Sater AA,Watts TH
12-7311-41 was used in Flow Cytometry to investigate how different subtypes of T cell antigen-presenting cell contribute to determining viral set point and disease outcome.
Tue Nov 21 00:00:00 EST 2017
A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.
The Journal of clinical investigation
Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.
The Journal of clinical investigation
Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2017
Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation.
Science translational medicine
Allen E,Jabouille A,Rivera LB,Lodewijckx I,Missiaen R,Steri V,Feyen K,Tawney J,Hanahan D,Michael IP,Bergers G
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Wed Apr 12 00:00:00 EDT 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Jun 05 00:00:00 EDT 2017
DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.
The Journal of experimental medicine
Lehmann CHK,Baranska A,Heidkamp GF,Heger L,Neubert K,Lühr JJ,Hoffmann A,Reimer KC,Brückner C,Beck S,Seeling M,Kießling M,Soulat D,Krug AB,Ravetch JV,Leusen JHW,Nimmerjahn F,Dudziak D
12-7311 was used in Flow cytometry/Cell sorting to suggest that targeting antigens to FcγRs on DCs may be a promising approach to raise immunogenic or tolerogenic T cell responses to antigens of choice.
Mon May 01 00:00:00 EDT 2017
Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand.
Cancer research
Kang SW,Lee SC,Park SH,Kim J,Kim HH,Lee HW,Seo SK,Kwon BS,Cho HR,Kwon B
12-7311-41 was used in Flow Cytometry to report findings related to reverse signaling by CD137 ligand (CD137L) in antigen-presenting dendritic cells (DC) in tumors that address these paradoxical results.
Wed Nov 01 00:00:00 EDT 2017
Microbial, metabolomic, and immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency.
Gut microbes
Jacobs JP,Lin L,Goudarzi M,Ruegger P,McGovern DP,Fornace AJ,Borneman J,Xia L,Braun J
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Jan 02 00:00:00 EST 2017
A New Adjuvant MTOM Mediates Mycobacterium tuberculosis Subunit Vaccine to Enhance Th1-Type T Cell Immune Responses and IL-2+ T Cells.
Frontiers in immunology
Yu Q,Wang X,Fan X
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Wed Nov 20 00:00:00 EST 2019
Critical role of caspase-8-mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis.
Mucosal immunology
Qi X,Gurung P,Malireddi RK,Karmaus PW,Sharma D,Vogel P,Chi H,Green DR,Kanneganti TD
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2017
IRF-8 regulates expansion of myeloid-derived suppressor cells and Foxp3+ regulatory T cells and modulates Th2 immune responses to gastrointestinal nematode infection.
PLoS pathogens
Valanparambil RM,Tam M,Gros PP,Auger JP,Segura M,Gros P,Jardim A,Geary TG,Ozato K,Stevenson MM
12-7311 was used in Flow cytometry/Cell sorting to study the role of interferon regulatory factor-8 on Th2 immunity to Helimosomoides polygyrus bakeri infection.
Sun Oct 01 00:00:00 EDT 2017
Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice.
Acta pharmacologica Sinica
Zhou YQ,Weng XF,Dou R,Tan XS,Zhang TT,Fang JB,Wu XW
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2017
Role of Triggering Receptor Expressed on Myeloid Cell-1 Expression in Mammalian Target of Rapamycin Modulation of CD8+ T-cell Differentiation during the Immune Response to Invasive Pulmonary Aspergillosis.
Chinese medical journal
Cui N,Wang H,Su LX,Zhang JH,Long Y,Liu DW
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Sat May 20 00:00:00 EDT 2017
Batf3-dependent CD8α+ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages.
EBioMedicine
Li Y,Liu X,Duan W,Tian H,Zhu G,He H,Yao S,Yi S,Song W,Tang H
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2017
Development of effective tumor immunotherapy using a novel dendritic cell-targeting Toll-like receptor ligand.
PloS one
De Silva NH,Akazawa T,Wijewardana V,Inoue N,Oyamada M,Ohta A,Tachibana Y,Wijesekera DPH,Kuwamura M,Nishizawa Y,Itoh K,Izawa T,Hatoya S,Hasegawa T,Yamate J,Inaba T,Sugiura K
12-7311 was used in Flow cytometry/Cell sorting to show that the combined treatment gave rise to emphatic amelioration in DC-based cancer therapy.
Tue Dec 26 00:00:00 EST 2017
Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation.
Scientific reports
Zhang H,Qi Y,Yuan Y,Cai L,Xu H,Zhang L,Su B,Nie H
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Feb 06 00:00:00 EST 2017
Multi-level Strategy for Identifying Proteasome-Catalyzed Spliced Epitopes Targeted by CD8+ T Cells during Bacterial Infection.
Cell reports
Platteel ACM,Liepe J,Textoris-Taube K,Keller C,Henklein P,Schalkwijk HH,Cardoso R,Kloetzel PM,Mishto M,Sijts AJAM
12-7311 was used in Flow cytometry/Cell sorting to show that PCPS expands the CD8+ T cell response against L. monocytogenes by exposing spliced epitopes on the cell surface.
Tue Aug 01 00:00:00 EDT 2017
IL-12 Influence mTOR to Modulate CD8+ T Cells Differentiation through T-bet and Eomesodermin in Response to Invasive Pulmonary Aspergillosis.
International journal of medical sciences
Wang H,Li J,Han Q,Yang F,Xiao Y,Xiao M,Xu Y,Su L,Cui N,Liu D
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon May 21 00:00:00 EDT 2018
The TLR7 agonist imiquimod induces anti-cancer effects via autophagic cell death and enhances anti-tumoral and systemic immunity during radiotherapy for melanoma.
Oncotarget
Cho JH,Lee HJ,Ko HJ,Yoon BI,Choe J,Kim KC,Hahn TW,Han JA,Choi SS,Jung YM,Lee KH,Lee YS,Jung YJ
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Apr 11 00:00:00 EDT 2017
Essential role for CCR6 in certain inflammatory diseases demonstrated using specific antagonist and knockin mice.
JCI insight
Robert R,Ang C,Sun G,Juglair L,Lim EX,Mason LJ,Payne NL,Bernard CC,Mackay CR
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Aug 03 00:00:00 EDT 2017
Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.
Nature communications
Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Oct 17 00:00:00 EDT 2017
Regulatory T cells and IL10 suppress pulmonary host defense during early-life exposure to radical containing combustion derived ultrafine particulate matter.
Respiratory research
Jaligama S,Saravia J,You D,Yadav N,Lee GI,Shrestha B,Cormier SA
12-7311 was used in Flow cytometry/Cell sorting to show that murine neonate exposure to environmentally persistent free radicals induces regulatory T Cells and IL10 resulting in suppressed adaptive T cell responses and increased severity of influenza.
Fri Jan 13 00:00:00 EST 2017
A Multistage Subunit Vaccine Effectively Protects Mice Against Primary Progressive Tuberculosis, Latency and Reactivation.
EBioMedicine
Ma J,Teng X,Wang X,Fan X,Wu Y,Tian M,Zhou Z,Li L
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2017
NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer.
Nature
Karki R,Man SM,Malireddi RKS,Kesavardhana S,Zhu Q,Burton AR,Sharma BR,Qi X,Pelletier S,Vogel P,Rosenstiel P,Kanneganti TD
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Dec 22 00:00:00 EST 2016
Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.
Cell
Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Oct 06 00:00:00 EDT 2016
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.
Cell
Clever D,Roychoudhuri R,Constantinides MG,Askenase MH,Sukumar M,Klebanoff CA,Eil RL,Hickman HD,Yu Z,Pan JH,Palmer DC,Phan AT,Goulding J,Gattinoni L,Goldrath AW,Belkaid Y,Restifo NP
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Aug 25 00:00:00 EDT 2016
Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission.
Immunity
Tian Y,Kuo CF,Akbari O,Ou JH
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue May 17 00:00:00 EDT 2016
Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression.
Nature immunology
Gerriets VA,Kishton RJ,Johnson MO,Cohen S,Siska PJ,Nichols AG,Warmoes MO,de Cubas AA,MacIver NJ,Locasale JW,Turka LA,Wells AD,Rathmell JC
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2016
Oligodendrocyte death results in immune-mediated CNS demyelination.
Nature neuroscience
Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2016
The composition of the microbiota modulates allograft rejection.
The Journal of clinical investigation
Lei YM,Chen L,Wang Y,Stefka AT,Molinero LL,Theriault B,Aquino-Michaels K,Sivan AS,Nagler CR,Gajewski TF,Chong AS,Bartman C,Alegre ML
12-7311 was used in Flow cytometry/Cell sorting to test the influence of host and donor microbiota on skin transplant rejection.
Fri Jul 01 00:00:00 EDT 2016
Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis.
Autophagy
Lee HY,Kim J,Quan W,Lee JC,Kim MS,Kim SH,Bae JW,Hur KY,Lee MS
12-7311 was used in Flow cytometry/Cell sorting to investigate how autophagy of MΦs is important for the control of inflammasome activation in response to metabolic or extrinsic stress.
Tue Aug 02 00:00:00 EDT 2016
Intranasal immunization with heat shock protein 60 induces CD4(+) CD25(+) GARP(+) and type 1 regulatory T cells and inhibits early atherosclerosis.
Clinical and experimental immunology
Zhong Y,Tang H,Wang X,Zeng Q,Liu Y,Zhao XI,Yu K,Shi H,Zhu R,Mao X
12-7311 was used in Flow cytometry/Cell sorting to investigate the impact of nasal heat shock protein 60 on atherosclerosis and the mechanisms underlying the anti-atherosclerosis responses.
Tue Mar 01 00:00:00 EST 2016
Age-dependent divergent effects of OX40L treatment on the development of diabetes in NOD mice.
Autoimmunity
Haddad CS,Bhattacharya P,Alharshawi K,Marinelarena A,Kumar P,El-Sayed O,Elshabrawy HA,Epstein AL,Prabhakar BS
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2016
Heterologous Immunity between Adenoviruses and Hepatitis C Virus: A New Paradigm in HCV Immunity and Vaccines.
PloS one
Singh S,Vedi S,Samrat SK,Li W,Kumar R,Agrawal B
12-7311 was used in Flow cytometry/Cell sorting to investigate the potential of a previously uncharacterized property of natural human adenovirus infection to dictate, modulate and/or alter the course of HCV infection upon exposure.
Tue Jul 19 00:00:00 EDT 2016
Protective efficacy of the chimeric Staphylococcus aureus vaccine candidate IC in sepsis and pneumonia models.
Scientific reports
Yang L,Cai C,Feng Q,Shi Y,Zuo Q,Yang H,Jing H,Wei C,Zhuang Y,Zou Q,Zeng H
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Feb 11 00:00:00 EST 2016
IL-22 dampens the T cell response in experimental malaria.
Scientific reports
Sellau J,Alvarado CF,Hoenow S,Mackroth MS,Kleinschmidt D,Huber S,Jacobs T
12-7311 was used in Flow cytometry/Cell sorting to study IL-22 levels during plasmodial infection in mice and the effect on an adaptive immune response.
Fri Jun 17 00:00:00 EDT 2016
Severe Changes in Thymic Microenvironment in a Chronic Experimental Model of Paracoccidioidomycosis.
PloS one
Alves da Costa T,Di Gangi R,Thomé R,Barreto Felisbino M,Pires Bonfanti A,Lumi Watanabe Ishikawa L,Sartori A,Burger E,Verinaud L
12-7311 was used in Flow cytometry/Cell sorting to develop a new experimental model where Pb yeast cells are injected through the intraperitoneal route and mice are evaluated over 120 days of infection.
Mon May 22 00:00:00 EDT 2017
CXCL16-positive dendritic cells enhance invariant natural killer T cell-dependent IFNγ production and tumor control.
Oncoimmunology
Veinotte L,Gebremeskel S,Johnston B
12-7311 was used in Flow cytometry/Cell sorting to study the co-stimulatory role of CXCR6/CXCL16 interactions in glycolipid-dependent invariant natural killer T (iNKT) cell activation and tumour control, showing that CXCL16-positive dendritic cells enhance iNKT cell-dependent IFNγ production and tumor control.
Wed Jun 01 00:00:00 EDT 2016
Reprogramming the immunological microenvironment through radiation and targeting Axl.
Nature communications
Aguilera TA,Rafat M,Castellini L,Shehade H,Kariolis MS,Hui AB,Stehr H,von Eyben R,Jiang D,Ellies LG,Koong AC,Diehn M,Rankin EB,Graves EE,Giaccia AJ
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Fri Dec 23 00:00:00 EST 2016
IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease.
Nature communications
Tosiek MJ,Fiette L,El Daker S,Eberl G,Freitas AA
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Fri Mar 11 00:00:00 EST 2016
IL-15 signaling promotes adoptive effector T-cell survival and memory formation in irradiation-induced lymphopenia.
Cell & bioscience
Xu A,Bhanumathy KK,Wu J,Ye Z,Freywald A,Leary SC,Li R,Xiang J
12-7311 was used in Flow cytometry/Cell sorting to investigate the mechanism for adoptively transferred effector T-cell survival and memory formation.
Mon May 09 00:00:00 EDT 2016
NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation.
Nature communications
Yang M,Chen S,Du J,He J,Wang Y,Li Z,Liu G,Peng W,Zeng X,Li D,Xu P,Guo W,Chang Z,Wang S,Tian Z,Dong Z
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Wed Sep 07 00:00:00 EDT 2016
mTOR masters monocytic myeloid-derived suppressor cells in mice with allografts or tumors.
Scientific reports
Wu T,Zhao Y,Wang H,Li Y,Shao L,Wang R,Lu J,Yang Z,Wang J,Zhao Y
12-7311 was used in Flow cytometry/Cell sorting to offer evidence supporting that mTOR is an intrinsic factor essential for the differentiation and immunosuppressive function of M-MDSCs.
Mon Feb 01 00:00:00 EST 2016
Opposing Development of Cytotoxic and Follicular Helper CD4 T Cells Controlled by the TCF-1-Bcl6 Nexus.
Cell reports
Donnarumma T,Young GR,Merkenschlager J,Eksmond U,Bongard N,Nutt SL,Boyer C,Dittmer U,Le-Trilling VT,Trilling M,Bayer W,Kassiotis G
12-7311 was used in Flow cytometry/Cell sorting to determine the mechanism for the induction of CD4+ cytotxic T cells.
Tue Nov 01 00:00:00 EDT 2016
Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response.
The Journal of biological chemistry
Pasi S,Kant R,Surolia A
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Fri Jun 03 00:00:00 EDT 2016
Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma.
Journal for immunotherapy of cancer
Patel MA,Kim JE,Theodros D,Tam A,Velarde E,Kochel CM,Francica B,Nirschl TR,Ghasemzadeh A,Mathios D,Harris-Bookman S,Jackson CC,Jackson C,Ye X,Tran PT,Tyler B,Coric V,Selby M,Brem H,Drake CG,Pardoll DM,Lim M
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Wed May 18 00:00:00 EDT 2016
MHC-I and PirB Upregulation in the Central and Peripheral Nervous System following Sciatic Nerve Injury.
PloS one
Bombeiro AL,Thomé R,Oliveira Nunes SL,Monteiro Moreira B,Verinaud L,Oliveira AL
12731141 was used in flow cytometry to measure expression of major histocompatibility complex class one and paired immunoglobulin-like receptor B in the central and peripheral nervous system after sciatic nerve injury in mice
Wed Jul 26 00:00:00 EDT 2017
Identification of natural RORγ ligands that regulate the development of lymphoid cells.
Cell metabolism
Santori FR,Huang P,van de Pavert SA,Douglass EF,Leaver DJ,Haubrich BA,Keber R,Lorbek G,Konijn T,Rosales BN,Rozman D,Horvat S,Rahier A,Mebius RE,Rastinejad F,Nes WD,Littman DR
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Feb 03 00:00:00 EST 2015
MicroRNA-155-deficient dendritic cells cause less severe GVHD through reduced migration and defective inflammasome activation.
Blood
Chen S,Smith BA,Iype J,Prestipino A,Pfeifer D,Grundmann S,Schmitt-Graeff A,Idzko M,Beck Y,Prinz G,Finke J,Duyster J,Zeiser R
12-7311 was used in Flow cytometry/Cell sorting to indicate that during graft-versus-host disease, miR-155 promotes DC migration toward sites of ATP release accompanied by inflammasome activation.
Thu Jul 02 00:00:00 EDT 2015
A Threshold Level of Intratumor CD8+ T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1.
Cancer research
Ngiow SF,Young A,Jacquelot N,Yamazaki T,Enot D,Zitvogel L,Smyth MJ
12-7311 was used in Flow cytometry/Cell sorting to provide a framework to interrogate intra-tumour CD8(+) T-cell PD1 and immune PDL1 levels and response in human cancer.
Tue Sep 15 00:00:00 EDT 2015
MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.
Proceedings of the National Academy of Sciences of the United States of America
Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Dec 29 00:00:00 EST 2015
Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension.
Proceedings of the National Academy of Sciences of the United States of America
Hashimoto-Kataoka T,Hosen N,Sonobe T,Arita Y,Yasui T,Masaki T,Minami M,Inagaki T,Miyagawa S,Sawa Y,Murakami M,Kumanogoh A,Yamauchi-Takihara K,Okumura M,Kishimoto T,Komuro I,Shirai M,Sakata Y,Nakaoka Y
12-7311 was used in Flow cytometry/Cell sorting to suggest that IL-21 promotes PAH in association with M2 macrophage polarisation, downstream of IL-6-signalling.
Tue May 19 00:00:00 EDT 2015
Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells.
Frontiers in immunology
Vogel AJ,Brown DM
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Fri Jul 10 00:00:00 EDT 2015
IL-27 Signaling Is Crucial for Survival of Mice Infected with African Trypanosomes via Preventing Lethal Effects of CD4+ T Cells and IFN-γ.
PLoS pathogens
Liu G,Xu J,Wu H,Sun D,Zhang X,Zhu X,Magez S,Shi M
12-7311 was used in Flow cytometry/Cell sorting to investigate the role of IL-27 in African trypanosomes infection, showing that IL-27 signalling is crucial by preventing lethal effects of CD4+ T cells and IFN-γ.
Wed Jul 01 00:00:00 EDT 2015
The Flavonoid Isoliquiritigenin Reduces Lung Inflammation and Mouse Morbidity during Influenza Virus Infection.
Antimicrobial agents and chemotherapy
Traboulsi H,Cloutier A,Boyapelly K,Bonin MA,Marsault É,Cantin AM,Richter MV
12-7311 was used in Flow cytometry/Cell sorting to investigate the anti-inflammatory and antiviral activities of isoliquiritigenin during influenza virus infection.
Thu Oct 01 00:00:00 EDT 2015
The MAPK-Activated Kinase MK2 Attenuates Dendritic Cell-Mediated Th1 Differentiation and Autoimmune Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Soukup K,Halfmann A,Le Bras M,Sahin E,Vittori S,Poyer F,Schuh C,Luger R,Niederreiter B,Haider T,Stoiber D,Blüml S,Schabbauer G,Kotlyarov A,Gaestel M,Felzmann T,Dohnal AM
12-7311 was used in Flow cytometry/Cell sorting to investigate the role of MK2 in dendritic cells, showing that it attenuates dendritic cell-mediated Th1 differentiation and autoimmune encephalomyelitis.
Wed Jul 15 00:00:00 EDT 2015
IL-15 Superagonist-Mediated Immunotoxicity: Role of NK Cells and IFN-γ.
Journal of immunology (Baltimore, Md. : 1950)
Guo Y,Luan L,Rabacal W,Bohannon JK,Fensterheim BA,Hernandez A,Sherwood ER
12-7311 was used in Flow cytometry/Cell sorting to investigate the effect of IL-15 SA on physiologic and immunologic functions of mice.
Tue Sep 01 00:00:00 EDT 2015
Leptin receptor signaling in T cells is required for Th17 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Reis BS,Lee K,Fanok MH,Mascaraque C,Amoury M,Cohn LB,Rogoz A,Dallner OS,Moraes-Vieira PM,Domingos AI,Mucida D
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Jun 01 00:00:00 EDT 2015
IκBNS regulates murine Th17 differentiation during gut inflammation and infection.
Journal of immunology (Baltimore, Md. : 1950)
Annemann M,Wang Z,Plaza-Sirvent C,Glauben R,Schuster M,Ewald Sander F,Mamareli P,Kühl AA,Siegmund B,Lochner M,Schmitz I
12-7311 was used in Flow cytometry/Cell sorting to study the role of nuclear IκBNS in murine Th17 cell generation upon inflammation and infection.
Sun Mar 15 00:00:00 EDT 2015
A tumor lysate is an effective vaccine antigen for the stimulation of CD4(+) T-cell function and subsequent induction of antitumor immunity mediated by CD8(+) T cells.
Cancer biology & therapy
Kawahara M,Takaku H
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Sep 12 00:00:00 EDT 2016
Adjuvants may reduce in vivo transfection levels for DNA vaccination in mice leading to reduced antigen-specific CD8+ T cell responses.
Human vaccines & immunotherapeutics
Rose AH,Hoffmann FW,Hara JH,Urschitz J,Moisyadi S,Hoffmann PR,Bertino P
12-7311 was used in Flow cytometry/Cell sorting to evaluate the adjuvant properties of cationic liposomes, Adjuplex and in vivo-JetPEI compared to injection of DNA without adjuvant.
Mon May 16 00:00:00 EDT 2016
Inadequate activation of the HBsAg-specific Th cells by APCs leads to hyporesponsiveness to HBsAg vaccine in B10.S mice.
Human vaccines & immunotherapeutics
Li X,Xu J,Lv Z,Wang J,Sun S,Zhu W,Wang B,He R,Qu D
12-7311 was used in Flow cytometry/Cell sorting to study how the activities of APCs were significantly lower in mice immunised with HBsAg vaccine, resulting in an inferior activation of HBsAg-specific Th cells.
Tue Apr 19 00:00:00 EDT 2016
Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine.
Human vaccines & immunotherapeutics
Teng X,Tian M,Li J,Tan S,Yuan X,Yu Q,Jing Y,Zhang Z,Yue T,Zhou L,Fan X
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Fri Mar 11 00:00:00 EST 2016
Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules.
Gene therapy
Rodriguez-Peña AB,Gomez-Rodriguez J,Kortum RL,Palmer DC,Yu Z,Guittard GC,Wohlfert EA,Silver PB,Misplon JA,Sommers CL,Feigenbaum L,Epstein SL,Caspi RR,Belkaid Y,Restifo NP,Samelson LE,Balagopalan L
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2015
Toll-Like receptor 2 (TLR2) and TLR9 play opposing roles in host innate immunity against Salmonella enterica serovar Typhimurium infection.
Infection and immunity
Zhan R,Han Q,Zhang C,Tian Z,Zhang J
12-7311 was used in Flow cytometry/Cell sorting to investigate the roles of TLR2 and TLR9 in regulating innate immunity against oral infection of Salmonella enterica serovar Typhimurium in mice.
Wed Apr 01 00:00:00 EDT 2015
Trypanosoma cruzi trans-sialidase prevents elicitation of Th1 cell response via interleukin 10 and downregulates Th1 effector cells.
Infection and immunity
Ruiz Díaz P,Mucci J,Meira MA,Bogliotti Y,Musikant D,Leguizamón MS,Campetella O
12-7311 was used in Flow cytometry/Cell sorting to identify the interferons and interleukins released by immune cells in response to Trypanosoma cruzi infection.
Fri May 01 00:00:00 EDT 2015
Distinct Contributions of CD4+ and CD8+ T Cells to Pathogenesis of Trypanosoma brucei Infection in the Context of Gamma Interferon and Interleukin-10.
Infection and immunity
Liu G,Sun D,Wu H,Zhang M,Huan H,Xu J,Zhang X,Zhou H,Shi M
12-7311 was used in Immunocytochemistry to study the distinct roles of CD4 and CD8 T cells in the context of IFN-γ and IL-10 during Trypanosoma brucei infections.
Wed Jul 01 00:00:00 EDT 2015
ERβ and ERα Differentially Regulate NKT and Vγ4+ T-cell Activation and T-regulatory Cell Response in Coxsackievirus B3 Infected Mice.
Journal of clinical & cellular immunology
Huber S
12-7311 was used in Flow cytometry/Cell sorting to determine the relative role and mechanism of action of estrogen receptor alpha and beta in myocarditis susceptibility.
Tue Sep 29 00:00:00 EDT 2020
CD11c(hi) Dendritic Cells Regulate Ly-6C(hi) Monocyte Differentiation to Preserve Immune-privileged CNS in Lethal Neuroinflammation.
Scientific reports
Kim JH,Choi JY,Kim SB,Uyangaa E,Patil AM,Han YW,Park SY,Lee JH,Kim K,Eo SK
12-7311 was used in Flow cytometry/Cell sorting to define the contribution of DCs to T cell-independent innate defence in immune-privileged CNS upon infection with neurotropic viruses.
Wed Dec 02 00:00:00 EST 2015
The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance.
Cell reports
Hermann-Kleiter N,Klepsch V,Wallner S,Siegmund K,Klepsch S,Tuzlak S,Villunger A,Kaminski S,Pfeifhofer-Obermair C,Gruber T,Wolf D,Baier G
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue Sep 29 00:00:00 EDT 2015
Immunostimulatory Effects Triggered by Enterococcus faecalis CECT7121 Probiotic Strain Involve Activation of Dendritic Cells and Interferon-Gamma Production.
PloS one
Molina MA,Díaz AM,Hesse C,Ginter W,Gentilini MV,Nuñez GG,Canellada AM,Sparwasser T,Berod L,Castro MS,Manghi MA
12-7311 was used in Flow cytometry/Cell sorting to elucidate the influence of E. faecalis CECT7121 on dendritic cells and the outcome of the immune responses.
Tue Apr 19 00:00:00 EDT 2016
Near-infrared photoactivatable control of Ca(2+) signaling and optogenetic immunomodulation.
eLife
He L,Zhang Y,Ma G,Tan P,Li Z,Zang S,Wu X,Jing J,Fang S,Zhou L,Wang Y,Huang Y,Hogan PG,Han G,Zhou Y
12-7311 was used in Flow cytometry/Cell sorting to represent a step forward towards the goal of achieving remote and wireless control of Ca(2+)-modulated activities with tailored function.
Tue Dec 08 00:00:00 EST 2015
Near-infrared photoactivatable control of Ca(2+) signaling and optogenetic immunomodulation.
eLife
He L,Zhang Y,Ma G,Tan P,Li Z,Zang S,Wu X,Jing J,Fang S,Zhou L,Wang Y,Huang Y,Hogan PG,Han G,Zhou Y
12-7311 was used in Flow cytometry/Cell sorting to represent a step forward towards the goal of achieving remote and wireless control of Ca(2+)-modulated activities with tailored function.
Tue Dec 08 00:00:00 EST 2015
CD8+ T Cells Mediate Female-Dominant IL-4 Production and Airway Inflammation in Allergic Asthma.
PloS one
Ito C,Okuyama-Dobashi K,Miyasaka T,Masuda C,Sato M,Kawano T,Ohkawara Y,Kikuchi T,Takayanagi M,Ohno I
12-7311 was used in Flow cytometry/Cell sorting to determine the mechanisms behind the sex differences in asthmatic responses after puberty.
Wed Jul 06 00:00:00 EDT 2016
A Multiple Antigenic Peptide Mimicking Peptidoglycan Induced T Cell Responses to Protect Mice from Systemic Infection with Staphylococcus aureus.
PloS one
Wang XY,Huang ZX,Chen YG,Lu X,Zhu P,Wen K,Fu N,Liu BY
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Tue May 24 00:00:00 EDT 2016
Targeting the inhibitory receptor CTLA-4 on T cells increased abscopal effects in murine mesothelioma model.
Oncotarget
Wu L,Wu MO,De la Maza L,Yun Z,Yu J,Zhao Y,Cho J,de Perrot M
12-7311 was used in Flow cytometry/Cell sorting to investigate the local and abscopal effects of targeting the CTLA-4 T cell inhibitory receptor in a murine mesothelioma model.
Wed May 20 00:00:00 EDT 2015
CD4+ T cells promote the transition from hypertrophy to heart failure during chronic pressure overload.
Circulation
Laroumanie F,Douin-Echinard V,Pozzo J,Lairez O,Tortosa F,Vinel C,Delage C,Calise D,Dutaur M,Parini A,Pizzinat N
12-7311 was used in Flow cytometry/Cell sorting to investigate the involvement of T cells in the progression to heart failure using a transverse aortic constriction (TAC) model.
Tue May 27 00:00:00 EDT 2014
TLR2 engagement on CD4(+) T cells enhances effector functions and protective responses to Mycobacterium tuberculosis.
European journal of immunology
Reba SM,Li Q,Onwuzulike S,Ding X,Karim AF,Hernandez Y,Fulton SA,Harding CV,Lancioni CL,Nagy N,Rodriguez ME,Wearsch PA,Rojas RE
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Thu May 01 00:00:00 EDT 2014
Prophylaxis with a respiratory syncytial virus (RSV) anti-G protein monoclonal antibody shifts the adaptive immune response to RSV rA2-line19F infection from Th2 to Th1 in BALB/c mice.
Journal of virology
Boyoglu-Barnum S,Chirkova T,Todd SO,Barnum TR,Gaston KA,Jorquera P,Haynes LM,Tripp RA,Moore ML,Anderson LJ
12-7311 was used in Flow cytometry/Cell sorting to suggest that the RSV G protein not only contributes to disease, but also dampens the host immune response to infection.
Mon Sep 01 00:00:00 EDT 2014
Dectin-2 regulates the effector phase of house dust mite-elicited pulmonary inflammation independently from its role in sensitization.
Journal of immunology (Baltimore, Md. : 1950)
Parsons MW,Li L,Wallace AM,Lee MJ,Katz HR,Fernandez JM,Saijo S,Iwakura Y,Austen KF,Kanaoka Y,Barrett NA
12-7311 was used in Flow cytometry/Cell sorting to reveal that Dectin-2 regulates monocyte-derived DC function in the pulmonary microenvironment at Dermatophagoides farinae challenge.
Sat Feb 15 00:00:00 EST 2014
Innate PI3K p110δ regulates Th1/Th17 development and microbiota-dependent colitis.
Journal of immunology (Baltimore, Md. : 1950)
Steinbach EC,Kobayashi T,Russo SM,Sheikh SZ,Gipson GR,Kennedy ST,Uno JK,Mishima Y,Borst LB,Liu B,Herfarth H,Ting JP,Sartor RB,Plevy SE
12-7311 was used in Flow cytometry/Cell sorting to explore the role of IL-10 and IL-12/23 in the development of microbiota-dependent colitis.
Tue Apr 15 00:00:00 EDT 2014
JNK2 regulates the functional plasticity of naturally occurring T regulatory cells and the enhancement of lung allergic responses.
Journal of immunology (Baltimore, Md. : 1950)
Joetham A,Schedel M,Takeda K,Jia Y,Ashino S,Dakhama A,Lluis A,Okamoto M,Gelfand EW
12-7311 was used in Flow cytometry/Cell sorting to study the mechanism by which GITR stimulation of naturally occurring regulatory T cells triggers the loss of regulatory function while concomitantly gaining pathogenic CD4(+) effector function.
Mon Sep 01 00:00:00 EDT 2014
Central role of conventional dendritic cells in regulation of bone marrow release and survival of neutrophils.
Journal of immunology (Baltimore, Md. : 1950)
Jiao J,Dragomir AC,Kocabayoglu P,Rahman AH,Chow A,Hashimoto D,Leboeuf M,Kraus T,Moran T,Carrasco-Avino G,Friedman SL,Merad M,Aloman C
12-7311 was used in Flow cytometry/Cell sorting to investigate the role of dendritic cells in neutrophil homeostasis, showing a central role in regulation of bone marrow release and survival of neutrophils.
Tue Apr 01 00:00:00 EDT 2014
Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Sahin E,Haubenwallner S,Kuttke M,Kollmann I,Halfmann A,Dohnal AM,Chen L,Cheng P,Hoesel B,Einwallner E,Brunner J,Kral JB,Schrottmaier WC,Thell K,Saferding V,Blüml S,Schabbauer G
12-7311 was used in Flow cytometry/Cell sorting to study the role of extracellular Arginase I in inflammation and immunity.
Fri Aug 15 00:00:00 EDT 2014
Immunosuppression by N-methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells.
Molecular and cellular biology
Kahlfuß S,Simma N,Mankiewicz J,Bose T,Lowinus T,Klein-Hessling S,Sprengel R,Schraven B,Heine M,Bommhardt U
12-7311 was used in Flow cytometry/Cell sorting to investigate the effect of NMDAR antagonists on T-cell function, showing that antagonists cause immunosuppression via inhibition of Kv1.3 and KCa3.1 channels in T-cells.
Sat Mar 01 00:00:00 EST 2014
Antagonizing arachidonic acid-derived eicosanoids reduces inflammatory Th17 and Th1 cell-mediated inflammation and colitis severity.
Mediators of inflammation
Monk JM,Turk HF,Fan YY,Callaway E,Weeks B,Yang P,McMurray DN,Chapkin RS
12-7311 was used in Flow cytometry/Cell sorting to investigate the relationship between PGE2 levels and Th17 cells in regard to disease outcomes in a mouse model of colitis.
Wed Apr 08 00:00:00 EDT 2015
Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.
Human vaccines & immunotherapeutics
Wang S,Wu B,Xue J,Wang M,Chen R,Wang B
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Jan 05 00:00:00 EST 2015
Helminth-induced interleukin-4 abrogates invariant natural killer T cell activation-associated clearance of bacterial infection.
Infection and immunity
Hsieh YJ,Fu CL,Hsieh MH
12-7311 was used in Flow cytometry/Cell sorting to reveal a previously unappreciated role for helminth-induced IL-4 in impairment of iNKT cell-mediated clearance of bacterial coexposure.
Thu May 01 00:00:00 EDT 2014
Exposure to combustion generated environmentally persistent free radicals enhances severity of influenza virus infection.
Particle and fibre toxicology
Lee GI,Saravia J,You D,Shrestha B,Jaligama S,Hebert VY,Dugas TR,Cormier SA
12-7311 was used in Flow cytometry/Cell sorting to study how EPFR-induced oxidative stress resulted in increased presence of Tregs in the lungs and subsequent suppression of adaptive immune response to influenza.
Thu Oct 30 00:00:00 EDT 2014
Myelin-specific T helper 17 cells promote adult hippocampal neurogenesis through indirect mechanisms.
F1000Research
Niebling J,E Rünker A,Schallenberg S,Kretschmer K,Kempermann G
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Fri Mar 06 00:00:00 EST 2020
Phenotypic Identification of Spinal Cord-Infiltrating CD4+ T Lymphocytes in a Murine Model of Neuropathic Pain.
Journal of pain & relief
Draleau K,Maddula S,Slaiby A,Nutile-McMenemy N,De Leo J,Cao L
12-7311 was used in Flow cytometry/Cell sorting to investigate the phenotype of spinal cord-infiltrating CD4+ T lymphocytes involved in the maintenance of neuropathic pain in a murine model.
Sun Jun 01 00:00:00 EDT 2014
Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome.
Molecular therapy. Methods & clinical development
Shimizu K,Sakurai F,Tomita K,Nagamoto Y,Nakamura S,Katayama K,Tachibana M,Kawabata K,Mizuguchi H
12-7311 was used in Flow cytometry/Cell sorting to investigate how insertion of microRNA-targeted sequences into replication-incompetent adenovirus vector genomes can suppress leaky expression of adenoviral genes.
Wed May 27 00:00:00 EDT 2015
Differential potency of regulatory T cell-mediated immunosuppression in kidney tumors compared to subcutaneous tumors.
Oncoimmunology
Devaud C,Westwood JA,Teng MW,John LB,Yong CS,Duong CP,Smyth MJ,Darcy PK,Kershaw MH
12-7311 was used in Flow cytometry/Cell sorting to provide insights into the immunosuppressive nature of the immune response generated in the kidney microenvironment.
Sat Nov 01 00:00:00 EDT 2014
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.
Nature immunology
Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.
Cardiovascular research
Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
Delayed anti-CD3 therapy results in depletion of alloreactive T cells and the dominance of Foxp3+ CD4+ graft infiltrating cells.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Goto R,You S,Zaitsu M,Chatenoud L,Wood KJ
12-7311 was used in Flow cytometry/Cell sorting to investigate the result of delayed anti-CD3 therapy on the number and dominance of alloreactive/graft infiltrating cells.
Mon Jul 01 00:00:00 EDT 2013
Protection of islet grafts through transforming growth factor-β-induced tolerogenic dendritic cells.
Diabetes
Thomas DC,Wong FS,Zaccone P,Green EA,Wållberg M
12-7311 was used in Flow cytometry/Cell sorting to investigate methods to achieve long-term β-islet graft tolerance for diabetes type 1, showing that islets can be protected through expression of TGF-β.
Sun Sep 01 00:00:00 EDT 2013
IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis.
PLoS pathogens
De Luca A,Carvalho A,Cunha C,Iannitti RG,Pitzurra L,Giovannini G,Mencacci A,Bartolommei L,Moretti S,Massi-Benedetti C,Fuchs D,De Bernardis F,Puccetti P,Romani L
12-7311 was used in Immunohistochemistry to study host resistance and tolerance to the commensal fungus, Candida albicans, during vulvovaginal candidiasis.
Tue Feb 18 00:00:00 EST 2014
IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis.
PLoS pathogens
De Luca A,Carvalho A,Cunha C,Iannitti RG,Pitzurra L,Giovannini G,Mencacci A,Bartolommei L,Moretti S,Massi-Benedetti C,Fuchs D,De Bernardis F,Puccetti P,Romani L
12-7311 was used in Immunohistochemistry to study host resistance and tolerance to the commensal fungus, Candida albicans, during vulvovaginal candidiasis.
Tue Feb 18 00:00:00 EST 2014
Liver sinusoidal endothelial cell lectin inhibits CTL-dependent virus clearance in mouse models of viral hepatitis.
Journal of immunology (Baltimore, Md. : 1950)
Liu B,Wang M,Wang X,Zhao D,Liu D,Liu J,Chen PJ,Yang D,He F,Tang L
12-7311 was used in Flow cytometry/Cell sorting to elucidate the role of LSECtin in pathogenesis of viral infection, showing that its absence led to increased frequency in intrahepatic CTLs, leading to accelerated liver adenovirus clearance.
Mon Apr 15 00:00:00 EDT 2013
Reduced effectiveness of CD4+Foxp3+ regulatory T cells in CD28-deficient NOD.H-2h4 mice leads to increased severity of spontaneous autoimmune thyroiditis.
Journal of immunology (Baltimore, Md. : 1950)
Ellis JS,Hong SH,Zaghouani H,Braley-Mullen H
12-7311 was used in Flow cytometry/Cell sorting to examine the role of Tregs in the development of iodine-accelerated spontaneous autoimmune thyroiditis in mice.
Fri Nov 15 00:00:00 EST 2013
Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Ohta S,Imamura M,Xing W,Boyce JA,Balestrieri B
12-7311 was used in Flow cytometry/Cell sorting to identify a unique function for gV-sPLA2 in the activation and recruitment of immune cells.
Sat Jun 15 00:00:00 EDT 2013
Markers of nonselective and specific NK cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Fogel LA,Sun MM,Geurs TL,Carayannopoulos LN,French AR
12-7311 was used in Flow cytometry/Cell sorting to demonstrate that a combination of Sca-1, CD27, and KLRG1 can distinguish NK cells based on their mechanism of activation.
Sat Jun 15 00:00:00 EDT 2013
Glucocorticoid receptor-dependent immunomodulatory effect of ursodeoxycholic acid on liver lymphocytes in mice.
American journal of physiology. Gastrointestinal and liver physiology
Takigawa T,Miyazaki H,Kinoshita M,Kawarabayashi N,Nishiyama K,Hatsuse K,Ono S,Saitoh D,Seki S,Yamamoto J
12-7311 was used in Flow cytometry/Cell sorting to investigate the immunomodulatory effect of ursodeoxycholic acid on experimental hepatitis, endotoxin shock, and bacterial infection in mice.
Sun Sep 15 00:00:00 EDT 2013
Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice.
Human vaccines & immunotherapeutics
Wu B,Zou Q,Hu Y,Wang B
12-7311 was used in Flow cytometry/Cell sorting to investigate how IL-22 might be used as an effective adjuvant to enhance cellular immune responses during HBsAg DNA vaccination.
Tue Oct 01 00:00:00 EDT 2013
Ontogeny and localization of the cells produce IL-2 in healthy animals.
Cytokine
Yamamoto M,Seki Y,Iwai K,Ko I,Martin A,Tsuji N,Miyagawa S,Love RB,Iwashima M
12-7311 was used in Immunofluorescence to study how a group of Tr1 cells may have additional roles in immune homeostasis through IL-2 production to aid in the maintenance of other regulatory T cells..
Fri Mar 01 00:00:00 EST 2013
Thymic stromal lymphopoietin attenuates the development of atherosclerosis in ApoE-/- mice.
Journal of the American Heart Association
Yu K,Zhu P,Dong Q,Zhong Y,Zhu Z,Lin Y,Huang Y,Meng K,Ji Q,Yi G,Zhang W,Wu B,Mao Y,Cheng P,Zhao X,Mao X,Zeng Q
12-7311 was used in Flow cytometry/Cell sorting to examine the phenotype of TSLP-conditioned bone marrow dendritic cells of apolipoprotein E-deficient mice and their capacity to induce the differentiation of Tregs.
Wed Aug 28 00:00:00 EDT 2013
Toll-like receptor agonists and alpha-galactosylceramide synergistically enhance the production of interferon-gamma in murine splenocytes.
Scientific reports
Ando T,Ito H,Ohtaki H,Seishima M
12-7311 was used in Flow cytometry/Cell sorting to explore the effects of the costimulation of GalCer and TLR agonists on the immune system and cytokine production.
Fri Feb 14 00:00:00 EST 2014
Resistance to malaria by enhanced phagocytosis of erythrocytes in LMP7-deficient mice.
PloS one
Duan X,Imai T,Chou B,Tu L,Himeno K,Suzue K,Hirai M,Taniguchi T,Okada H,Shimokawa C,Hisaeda H
12-7311 was used in Flow cytometry/Cell sorting to study how RBCs of LMP7-deficient mice were more likely to deform in response to infection with malaria parasites.
Tue Sep 17 00:00:00 EDT 2013
Host-derived CD4+ T cells attenuate stem cell-mediated transfer of autoimmune arthritis in lethally irradiated C57BL/6.g7 mice.
Arthritis and rheumatism
Rajasekaran N,Wang N,Truong P,Rinderknecht C,Macaubas C,Beilhack GF,Shizuru JA,Mellins ED
12-7311 was used in Flow cytometry/Cell sorting to discover that host CD4+ T cells have a regulatory phenotype in B6.g7 reconstituted mice and attenuate autoimmunity.
Fri Mar 01 00:00:00 EST 2013
A specific role for TLR1 in protective T(H)17 immunity during mucosal infection.
The Journal of experimental medicine
DePaolo RW,Kamdar K,Khakpour S,Sugiura Y,Wang W,Jabri B
12-7311 was used in Flow cytometry/Cell sorting to study the role of TLR1 in TH17 cell responses during Yersinia enterocolitica infection.
Mon Jul 30 00:00:00 EDT 2012
Increased protection from vaccinia virus infection in mice genetically prone to lymphoproliferative disorders.
Journal of virology
Seedhom MO,Mathurin KS,Kim SK,Welsh RM
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Fri Jun 01 00:00:00 EDT 2012
Treatment with targeted vesicular stomatitis virus generates therapeutic multifunctional anti-tumor memory CD4 T cells.
Cancer gene therapy
Gao Y,Whitaker-Dowling P,Griffin JA,Bergman I
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Sun Apr 01 00:00:00 EDT 2012
CD4 T cells play important roles in maintaining IL-17-producing γδ T-cell subsets in naive animals.
Immunology and cell biology
Do JS,Visperas A,O'Brien RL,Min B
12-7311 was used in Flow cytometry/Cell sorting to investigate the mechanism underlying the regulation of αβ and γδ T-cell homeostasis, showing that CD4 T cells play important roles in maintaining IL-17-producing subsets.
Sun Apr 01 00:00:00 EDT 2012
B7-CD28 costimulatory signals control the survival and proliferation of murine and human γδ T cells via IL-2 production.
Journal of immunology (Baltimore, Md. : 1950)
Ribot JC,Debarros A,Mancio-Silva L,Pamplona A,Silva-Santos B
12-7311 was used in Flow cytometry/Cell sorting to show that CD28 signals are required for IL-2-mediated survival and proliferation of both CD27(+) and CD27(-) γδ T cell subsets.
Wed Aug 01 00:00:00 EDT 2012
Requirement for diverse TCR specificities determines regulatory T cell activity in a mouse model of autoimmune arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Oh S,Aitken M,Simons DM,Basehoar A,Garcia V,Kropf E,Caton AJ
12-7311 was used in Flow cytometry/Cell sorting to investigate why CD4(+)CD25(+)Foxp3(+) Tregs allow organ-specific autoimmunity, showing that polyclonal Tregs suppressed Th17 cell formation and prevented arthritis development, but clonotypic Tregs did not, indicating that diverse TCR specificities are required.
Tue May 01 00:00:00 EDT 2012
Protective role for TLR4 signaling in atherosclerosis progression as revealed by infection with a common oral pathogen.
Journal of immunology (Baltimore, Md. : 1950)
Hayashi C,Papadopoulos G,Gudino CV,Weinberg EO,Barth KR,Madrigal AG,Chen Y,Ning H,LaValley M,Gibson FC,Hamilton JA,Genco CA
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Mon Oct 01 00:00:00 EDT 2012
IFN-γ production by allogeneic Foxp3+ regulatory T cells is essential for preventing experimental graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)
Koenecke C,Lee CW,Thamm K,Föhse L,Schafferus M,Mittrücker HW,Floess S,Huehn J,Ganser A,Förster R,Prinz I
12-7311 was used in Flow cytometry/Cell sorting to elucidate the mechanisms behind the essential immune-regulatory functions that are required for the prevention of experimental GVHD.
Sat Sep 15 00:00:00 EDT 2012
Evaluation of Lassa virus vaccine immunogenicity in a CBA/J-ML29 mouse model.
Vaccine
Goicochea MA,Zapata JC,Bryant J,Davis H,Salvato MS,Lukashevich IS
12-7311 was used in Flow cytometry/Cell sorting to determine the usefulness of a CBA/J-ML29 mouse model as a tool for evaluating the efficacy of vaccine candidates against LASV.
Tue Feb 14 00:00:00 EST 2012
Epigenetic alterations may regulate temporary reversal of CD4(+) T cell activation caused by trichloroethylene exposure.
Toxicological sciences : an official journal of the Society of Toxicology
Gilbert KM,Nelson AR,Cooney CA,Reisfeld B,Blossom SJ
12-7311 was used in Flow cytometry/Cell sorting to investigate the epigenetic effects of trichloroethylene exposure on the activation state of CD4+ T cells.
Tue May 01 00:00:00 EDT 2012
Immunogenic comparison of chimeric adenovirus 5/35 vector carrying optimized human immunodeficiency virus clade C genes and various promoters.
PloS one
Shoji M,Yoshizaki S,Mizuguchi H,Okuda K,Shimada M
12-7311 was used in Flow cytometry/Cell sorting to explore transgene protein expression and its immunogenicity using optimized codon usage, promoters and adaptors.
Mon Jun 04 00:00:00 EDT 2012
Differential effects of IL-12 on Tregs and non-Treg T cells: roles of IFN-γ, IL-2 and IL-2R.
PloS one
Zhao J,Zhao J,Perlman S
12-7311 was used in Flow cytometry/Cell sorting to investigate whether loss of immunosuppression occurs when IFN-γ is expressed by Tregs, showing differential effects of IL-12 on Tregs and non-Treg T cells.
Thu Feb 21 00:00:00 EST 2013
Interferon-γ-producing immature myeloid cells confer protection against severe invasive group A Streptococcus infections.
Nature communications
Matsumura T,Ato M,Ikebe T,Ohnishi M,Watanabe H,Kobayashi K
12-7311 was used in Flow cytometry/Cell sorting to indicate that interferon-γ-producing immature myeloid cells have a protective role during the early stage of severe invasive group A Streptococcus infections.
Tue Feb 14 00:00:00 EST 2012
Soluble MOG35-55/I-A(b) dimers ameliorate experimental autoimmune encephalomyelitis by reducing encephalitogenic T cells.
PloS one
Gong Y,Wang Z,Liang Z,Duan H,Ouyang L,Yu Q,Xu Z,Shen G,Weng X,Wu X
Published figure using IFN gamma monoclonal antibody (Product # 12-7311-41) in Flow Cytometry
Fri Jul 19 00:00:00 EDT 2013
Loss of T regulatory cell suppression following signaling through glucocorticoid-induced tumor necrosis receptor (GITR) is dependent on c-Jun N-terminal kinase activation.
The Journal of biological chemistry
Joetham A,Ohnishi H,Okamoto M,Takeda K,Schedel M,Domenico J,Dakhama A,Gelfand EW
12-7311 was used in Flow cytometry/Cell sorting to demonstrate that regulation of JNK phosphorylation plays a central role in Treg cell function.
Fri May 18 00:00:00 EDT 2012
Interferon-γ production by neutrophils during bacterial pneumonia in mice.
American journal of respiratory and critical care medicine
Yamada M,Gomez JC,Chugh PE,Lowell CA,Dinauer MC,Dittmer DP,Doerschuk CM
12-7311 was used in Flow cytometry/Cell sorting to reveal that neutrophils produce IFN-γ early in the inflammatory response during pneumonia induced by some bacteria, but not others.
Sun May 15 00:00:00 EDT 2011
IFN-γ- and IL-10-expressing virus epitope-specific Foxp3(+) T reg cells in the central nervous system during encephalomyelitis.
The Journal of experimental medicine
Zhao J,Zhao J,Fett C,Trandem K,Fleming E,Perlman S
12-7311 was used in Flow cytometry/Cell sorting to show that pathogen epitope-specific Foxp3(+) T reg cells can be identified on the basis of cytokine production.
Mon Aug 01 00:00:00 EDT 2011
Exacerbated experimental autoimmune encephalomyelitis in mast-cell-deficient Kit W-sh/W-sh mice.
Laboratory investigation; a journal of technical methods and pathology
Piconese S,Costanza M,Musio S,Tripodo C,Poliani PL,Gri G,Burocchi A,Pittoni P,Gorzanelli A,Colombo MP,Pedotti R
12-7311 was used in Flow cytometry/Cell sorting to investigate the potential detrimental role of mast cells in experimental autoimmune encephalomyelitis.
Fri Apr 01 00:00:00 EDT 2011
Successful colon cancer eradication after chemoimmunotherapy is associated with profound phenotypic change of intratumoral myeloid cells.
Journal of immunology (Baltimore, Md. : 1950)
Medina-Echeverz J,Fioravanti J,Zabala M,Ardaiz N,Prieto J,Berraondo P
12-7311 was used in Flow cytometry/Cell sorting to demonstrate the combination of IL-12 and CPA eliminates intratumoral Treg and MDSC, while inducing the appearance of IMC within the tumor microenvironment.
Sat Jan 15 00:00:00 EST 2011
The magnitude of CD4(+) T-cell activation rather than TCR diversity determines the outcome of Leishmania infection in mice.
Parasite immunology
Xin L,Wanderley JL,Wang Y,Vargas-Inchaustegui DA,Soong L
12-7311 was used in Flow cytometry/Cell sorting to investigate TCR usage in Leishmania-specific, IFN-γ-producing CD4(+) T cells, showing that the magnitude of activation rather than TCR diversity determines the outcome of infection.
Tue Mar 01 00:00:00 EST 2011
Vaccination with Human Induced Pluripotent Stem Cells Creates an Antigen-Specific Immune Response Against HIV-1 gp160.
Frontiers in microbiology
Yoshizaki S,Nishi M,Kondo A,Kojima Y,Yamamoto N,Ryo A
12-7311 was used in Flow cytometry/Cell sorting to investigate whether human iPSCs (hiPSCs) have the ability to enhance specific immune responses against a HIV-1 antigen in a xenogenic mouse model.
Thu Jul 14 00:00:00 EDT 2011
IFN-{gamma} produced by CD8 T cells induces T-bet-dependent and -independent class switching in B cells in responses to alum-precipitated protein vaccine.
Proceedings of the National Academy of Sciences of the United States of America
Mohr E,Cunningham AF,Toellner KM,Bobat S,Coughlan RE,Bird RA,MacLennan IC,Serre K
12-7311 was used in Flow cytometry/Cell sorting to show T-bet dependence identifies distinct transcriptional pathways in B cells that regulate IFN-γ-induced switching to different IgG isotypes.
Tue Oct 05 00:00:00 EDT 2010
Tumor immunity against a simian virus 40 oncoprotein requires CD8+ T lymphocytes in the effector immune phase.
Journal of virology
Lowe DB,Shearer MH,Jumper CA,Bright RK,Kennedy RC
12-7311 was used in Flow cytometry/Cell sorting to identify role of recombinant SV40 Tag protein immunization in initiating a cytotoxic T-lymphocyte response during tumor cell dissemination and growth.
Fri Jan 01 00:00:00 EST 2010
8-methoxypsoralen plus ultraviolet A therapy acts via inhibition of the IL-23/Th17 axis and induction of Foxp3+ regulatory T cells involving CTLA4 signaling in a psoriasis-like skin disorder.
Journal of immunology (Baltimore, Md. : 1950)
Singh TP,Schön MP,Wallbrecht K,Michaelis K,Rinner B,Mayer G,Schmidbauer U,Strohmaier H,Wang XJ,Wolf P
12-7311 was used in Flow cytometry/Cell sorting to elucidate the mechanism of PUVA for treatment of psoriasis, showing that inhibition of the IL-23/Th17 axis and induction of Foxp3+ regulatory T cells involves CTLA4 signalling.
Tue Jun 15 00:00:00 EDT 2010
NK cells delay allograft rejection in lymphopenic hosts by downregulating the homeostatic proliferation of CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Zecher D,Li Q,Oberbarnscheidt MH,Demetris AJ,Shlomchik WD,Rothstein DM,Lakkis FG
12-7311 was used in Flow cytometry/Cell sorting to demonstrate that NK cells downregulate homeostatic CD8+ T-cell proliferation in lymphopenic environments by competing for IL-15.
Tue Jun 15 00:00:00 EDT 2010
Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignant mesothelioma.
Journal of immunology (Baltimore, Md. : 1950)
Anraku M,Tagawa T,Wu L,Yun Z,Keshavjee S,Zhang L,Johnston MR,de Perrot M
12-7311 was used in Flow cytometry/Cell sorting to evaluate the potential of a combined Treg blockade-permetrexed anti-tumour treatment.
Thu Jul 15 00:00:00 EDT 2010
Resistance to dengue virus infection in mice is potentiated by CXCL10 and is independent of CXCL10-mediated leukocyte recruitment.
Journal of immunology (Baltimore, Md. : 1950)
Ip PP,Liao F
12-7311 was used in Flow cytometry/Cell sorting to study how CXCL10(-/-) mice are more susceptible than wild-type mice to dengue virus infection.
Sat May 15 00:00:00 EDT 2010
PIPKI gamma 90 negatively regulates LFA-1-mediated adhesion and activation in antigen-induced CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Wernimont SA,Legate KR,Simonson WT,Fassler R,Huttenlocher A
12-7311 was used in Flow cytometry/Cell sorting to demonstrate the activity of PIPKI gamma 90 as a novel negative regulator of antigen-induced CD4+ T cell adhesion and activation.
Fri Oct 15 00:00:00 EDT 2010
Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Do JS,Fink PJ,Li L,Spolski R,Robinson J,Leonard WJ,Letterio JJ,Min B
12-7311 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the generation of gammadelta T cells, showing that it occurs via a TGF-beta 1-dependent mechanism.
Mon Feb 15 00:00:00 EST 2010
Increased killing of liver NK cells by Fas/Fas ligand and NKG2D/NKG2D ligand contributes to hepatocyte necrosis in virus-induced liver failure.
Journal of immunology (Baltimore, Md. : 1950)
Zou Y,Chen T,Han M,Wang H,Yan W,Song G,Wu Z,Wang X,Zhu C,Luo X,Ning Q
12-7311 was used in Immunocytochemistry to reveal a pivotal role for liver natural killer cells in the pathogenesis of virus-induced fulminant hepatic failure and acute-on-chronic liver failure.
Fri Jan 01 00:00:00 EST 2010
Mouse natural killer (NK) cells express the nerve growth factor receptor TrkA, which is dynamically regulated.
PloS one
Ralainirina N,Brons NH,Ammerlaan W,Hoffmann C,Hentges F,Zimmer J
12-7311 was used in Flow cytometry/Cell sorting to demonstrate that mouse NK cells dynamically express the NGF receptor TrkA.
Wed Dec 01 00:00:00 EST 2010
Activation-induced T helper cell death contributes to Th1/Th2 polarization following murine Schistosoma japonicum infection.
Journal of biomedicine & biotechnology
Xu X,Wen X,Chi Y,He L,Zhou S,Wang X,Zhao J,Liu F,Su C
12-7311 was used in Flow cytometry/Cell sorting to suggest that Th1 or Th2 cell apoptosis is preferentially induced by different schistosome antigens during different stages of infection.
Thu Apr 01 00:00:00 EDT 2010
In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression.
The Journal of experimental medicine
Webster KE,Walters S,Kohler RE,Mrkvan T,Boyman O,Surh CD,Grey ST,Sprent J
12-7311 was used in Flow cytometry/Cell sorting to study the role of T reg cells in the induction of resistance to EAE and long term acceptance of islet allografts.
Mon Apr 13 00:00:00 EDT 2009
Mycobacterium tuberculosis interferes with the response to infection by inducing the host EphA2 receptor.
The Journal of infectious diseases
Khounlotham M,Subbian S,Smith R,Cirillo SL,Cirillo JD
12-7311 was used in Flow cytometry/Cell sorting to suggest that induction of the erythropoietin-producing hepatoma (Eph) receptor, ephA2, is important for the survival of M. tuberculosis during latency.
Mon Jun 15 00:00:00 EDT 2009
Cross-presentation of male seminal fluid antigens elicits T cell activation to initiate the female immune response to pregnancy.
Journal of immunology (Baltimore, Md. : 1950)
Moldenhauer LM,Diener KR,Thring DM,Brown MP,Hayball JD,Robertson SA
12-7311 was used in Flow cytometry/Cell sorting to study how at conception, seminal fluid drives activation and expansion of paternal Ag-reactive CD4(+) and CD8(+) T cell populations.
Mon Jun 15 00:00:00 EDT 2009
Chimeric NKG2D T cells require both T cell- and host-derived cytokine secretion and perforin expression to increase tumor antigen presentation and systemic immunity.
Journal of immunology (Baltimore, Md. : 1950)
Barber A,Sentman CL
12-7311 was used in Flow cytometry/Cell sorting to determine the mechanisms that chNKG2D T cells require to induce host immunity against ovarian tumours and which of the host immune cells are involved in tumour elimination.
Sat Aug 15 00:00:00 EDT 2009
Multiple mechanisms contribute to the robust rapid gamma interferon response by CD8+ T cells during Listeria monocytogenes infection.
Infection and immunity
Bou Ghanem EN,McElroy DS,D'Orazio SE
12-7311 was used in Flow cytometry/Cell sorting to demonstrate the numerous pathways leading to the secretion of IFN-gamma by CD8+ T cells during infection.
Wed Apr 01 00:00:00 EDT 2009
Targeting of antigens to B cells augments antigen-specific T-cell responses and breaks immune tolerance to tumor-associated antigen MUC1.
Blood
Ding C,Wang L,Marroquin J,Yan J
12-7311 was used in Flow cytometry/Cell sorting to reveal that ovalbumin targeted to B cells via CD19 stimulates augmented CD4 and CD8 T-cell proliferation and expansion.
Wed Oct 01 00:00:00 EDT 2008
IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response.
Blood
Rubinstein MP,Lind NA,Purton JF,Filippou P,Best JA,McGhee PA,Surh CD,Goldrath AW
12-7311 was used in Flow cytometry/Cell sorting to study IL-7 and IL-15 regulation of CD8+ T-cell subsets during contraction of the immune response.
Sat Nov 01 00:00:00 EDT 2008
Dicer-dependent microRNA pathway safeguards regulatory T cell function.
The Journal of experimental medicine
Liston A,Lu LF,O'Carroll D,Tarakhovsky A,Rudensky AY
12-7311 was used in Flow cytometry/Cell sorting to study regulatory T cell-mediated tolerance, showing that it is dependent on the Dicer-controlled microRNA pathway.
Mon Sep 01 00:00:00 EDT 2008
Autoantibody production in lpr/lpr gld/gld mice reflects accumulation of CD4+ effector cells that are resistant to regulatory T cell activity.
Journal of autoimmunity
Hondowicz BD,Fields ML,Nish SA,Larkin J,Caton AJ,Erikson J
12-7311 was used in Flow cytometry/Cell sorting to show that Treg cells block lpr/lpr gld/gld Th cells from providing help to anti-chromatin B cells in an in vivo transfer system.
Mon Sep 01 00:00:00 EDT 2008
Galectin-1 functions as a Th2 cytokine that selectively induces Th1 apoptosis and promotes Th2 function.
European journal of immunology
Motran CC,Molinder KM,Liu SD,Poirier F,Miceli MC
12-7311 was used in Flow cytometry/Cell sorting to identify galectin-1 as a cross-regulatory cytokine that selectively antagonizes Th1 survival, while promoting TCR-induced Th2 cytokine production.
Sat Nov 01 00:00:00 EDT 2008
Inchoate CD8+ T cell responses in neonatal mice permit influenza-induced persistent pulmonary dysfunction.
Journal of immunology (Baltimore, Md. : 1950)
You D,Ripple M,Balakrishna S,Troxclair D,Sandquist D,Ding L,Ahlert TA,Cormier SA
12-7311 was used in Flow cytometry/Cell sorting to establish a neonatal mouse model of influenza infection to elucidate the mechanisms that induce severe pulmonary disease in infants.
Mon Sep 01 00:00:00 EDT 2008
Blockade of PD-1/B7-H1 interaction restores effector CD8+ T cell responses in a hepatitis C virus core murine model.
Journal of immunology (Baltimore, Md. : 1950)
Lukens JR,Cruise MW,Lassen MG,Hahn YS
12-7311 was used in Flow cytometry/Cell sorting to study the blockade of PD-1/B7-H1 interaction to restore effector CD8+ T cell responses in a hepatitis C virus core murine model.
Tue Apr 01 00:00:00 EDT 2008
Role of Valpha14+ NKT cells in the development of Hepatitis B virus-specific CTL: activation of Valpha14+ NKT cells promotes the breakage of CTL tolerance.
International immunology
Ito H,Ando K,Ishikawa T,Nakayama T,Taniguchi M,Saito K,Imawari M,Moriwaki H,Yokochi T,Kakumu S,Seishima M
12-7311 was used in Flow cytometry/Cell sorting to open up a new method for clearing the virus from patients with persistent HBV infection.
Tue Jul 01 00:00:00 EDT 2008
Combined anti-CD40 conditioning and well-timed immunization prolongs CD8+ T cell accumulation and control of established brain tumors.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Ryan CM,Staveley-O'Carroll K,Schell TD
12-7311 was used in Flow cytometry/Cell sorting to investigate the augmentation of CD8+ T-cell-mediated adoptive immunotherapy by targeting a weakly immunogenic epitope.
Mon Jul 13 00:00:00 EDT 2009
Characterization of T-cell immunogenicity of two PE/PPE proteins of Mycobacterium tuberculosis.
Journal of medical microbiology
Chaitra MG,Shaila MS,Nayak R
12-7311 was used in Flow cytometry/Cell sorting to demonstrate the immunogenicity of two PE/PPE proteins in BALB/c mice.
Mon Sep 01 00:00:00 EDT 2008
An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2.
The Journal of experimental medicine
Cho JH,Boyman O,Kim HO,Hahm B,Rubinstein MP,Ramsey C,Kim DM,Surh CD,Sprent J
12-7311 was used in Flow cytometry/Cell sorting to describe a novel form of homeostatic proliferation that occurs when naive T cells encounter raised levels of IL-2 and IL-15 in vivo.
Mon Aug 06 00:00:00 EDT 2007
Chimeric NKG2D modified T cells inhibit systemic T-cell lymphoma growth in a manner involving multiple cytokines and cytotoxic pathways.
Cancer research
Zhang T,Barber A,Sentman CL
12-7311 was used in Flow cytometry/Cell sorting to investigate the efficiency and mechanisms by which chimeric NKG2D-modified T cells inhibit systemic T-cell lymphoma growth.
Thu Nov 15 00:00:00 EST 2007
Activation of naturally occurring lung CD4(+)CD25(+) regulatory T cells requires CD8 and MHC I interaction.
Proceedings of the National Academy of Sciences of the United States of America
Joetham A,Takeda K,Miyahara N,Matsubara S,Ohnishi H,Koya T,Dakhama A,Gelfand EW
12-7311 was used in Flow cytometry/Cell sorting to demonstrate that functional activation of nTregs requires the interaction between MHC I on CD4(+)CD25(+) T cells and CD8.
Tue Sep 18 00:00:00 EDT 2007
Evaluation of T-cell responses to peptides with MHC class I-binding motifs derived from PE_PGRS 33 protein of Mycobacterium tuberculosis.
Journal of medical microbiology
Chaitra MG,Shaila MS,Nayak R
12-7311 was used in Flow cytometry/Cell sorting to study how PE_PGRS 33 has access to the MHC class I processing pathway, and how short peptide fragments of this protein can be presented to CD8+ T cells.
Sun Apr 01 00:00:00 EDT 2007
In vivo survival and homeostatic proliferation of natural killer cells.
The Journal of experimental medicine
Prlic M,Blazar BR,Farrar MA,Jameson SC
12-7311 was used in Flow cytometry/Cell sorting to show that mouse NK cells undergo homeostatic proliferation when transferred into NK-deficient Rag-/- gammaC-/- hosts.
Mon Apr 21 00:00:00 EDT 2003
